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Conserved domains on  [gi|568946421|ref|XP_006540358|]
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zinc finger protein 541 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SANT super family cl21498
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 1120-1163 9.61e-12

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


The actual alignment was detected with superfamily member cd11661:

Pssm-ID: 473887 [Multi-domain]  Cd Length: 46  Bit Score: 60.71  E-value: 9.61e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 568946421 1120 WTPMEKRLFKKAFCAHKKDFYLIHK-MIQTKSVAQCVEYYYIWKK 1163
Cdd:cd11661     2 WSESEAKLFEEGLRKYGKDFHDIRQdFLPWKSVGELVEFYYMWKK 46
ELM2 pfam01448
ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown ...
 1010-1065 5.57e-11

ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown function. It is found in the MTA1 protein that is part of the NuRD complex. The domain is usually found to the N terminus of a myb-like DNA binding domain pfam00249. ELM2 is also found associated with an ARID DNA binding domain pfam01388 in Swiss:O82364. This suggests that ELM2 may also be involved in DNA binding, or perhaps is a protein-protein interaction domain.


:

Pssm-ID: 460214  Cd Length: 53  Bit Score: 58.78  E-value: 5.57e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 568946421  1010 INVGSRFQAEIPELQERLLA--RVDENVASLVWKPwgdvmTNPETQDRVMELCNVACS 1065
Cdd:pfam01448    1 IRVGPRYQAEIPELLPPSEEedRYEEEDELLVWDP-----NHNLPDRKLDEYLVVARS 53
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 231-677 4.57e-05

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.40  E-value: 4.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946421  231 PEEEAYGDPTHNHDVANQP--PPSGLRSLGPPEARSPGSVLPNRDllrcivssivhQKIPSPGPAVGPSDTEARSSACAC 308
Cdd:PHA03247 2577 PSEPAVTSRARRPDAPPQSarPRAPVDDRGDPRGPAPPSPLPPDT-----------HAPDPPPPSPSPAANEPDPHPPPT 2645

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946421  309 PTSLGSSSCTPASTPVALGTLGSEIPEETHP------PRKEAATEVFTPVQSRAAENGVPDPPESELESESPRLQRP--- 379
Cdd:PHA03247 2646 VPPPERPRDDPAPGRVSRPRRARRLGRAAQAssppqrPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPpgp 2725

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946421  380 -SSLEGWPEGSSLPACLPLFRGHSVPSGSQPSSHnfqwlRNLPGCPKNKGSNVFMVHKPPAVASREGSEGGGSGPSSTPT 458
Cdd:PHA03247 2726 aAARQASPALPAAPAPPAVPAGPATPGGPARPAR-----PPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPS 2800

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946421  459 SVEPSPslgttqeellpfPPALLKAPGEA-SSEVRQAAGEDETWAPKKCKPDCESFPWQSPTELGLQDAqnPGGlPSDAT 537
Cdd:PHA03247 2801 PWDPAD------------PPAAVLAPAAAlPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVA--PGG-DVRRR 2865

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946421  538 PLFRQLFMKSQESlvSHEQMQVLQMIAKSQRIFSHTQVATASAQRPGPEGKQSTLKPLQGPWPPQTLPPAPTvdsfqigP 617
Cdd:PHA03247 2866 PPSRSPAAKPAAP--ARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPP-------P 2936

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946421  618 GHSEPEGSPvrrrKTMPAVSRETSPGGPRRDTKGGPKVASAPPSLTGPGLLPSRNPDSSS 677
Cdd:PHA03247 2937 PRPQPPLAP----TTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASS 2992
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 168-190 1.86e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 39.59  E-value: 1.86e-04
                           10        20
                   ....*....|....*....|...
gi 568946421   168 HVCKVCSKAFKRQDHLTGHMLTH 190
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5236 super family cl28715
Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];
80-329 3.64e-04

Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5236:

Pssm-ID: 227561 [Multi-domain]  Cd Length: 493  Bit Score: 44.63  E-value: 3.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946421   80 GKDSDSVKLLEE-----YADSESQTSLQDLGlgALKVPKEADEggRATGSTRKGKRQHSSPQNPLLdCSLCG---KVFS- 150
Cdd:COG5236   120 ITDRRQWKGREEkvgifYEGEDVRDEMEDLL--SFKCPKSKCH--RRCGSLKELKKHYKAQHGFVL-CSECIgnkKDFWn 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946421  151 -----SASSLSKHYLTHSQE---RKHV-CKVCSKAFKRQDHLTGHM-LTHQKTkpFVCIEQGCSKS--YCDYRSLRRHYE 218
Cdd:COG5236   195 eirlfRSSTLRDHKNGGLEEegfKGHPlCIFCKIYFYDDDELRRHCrLRHEAC--HICDMVGPIRYqyFKSYEDLEAHFR 272

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946421  219 VQHGVCILkETPPEEEAYGDPTHNHDVANQPPPSGLRSLGPPEARSPGSVLPnrdllrcIVSSIVHQKIPSPGPAVGPSD 298
Cdd:COG5236   273 NAHYCCTF-QTCRVGKCYVFPYHTELLEHLTRFHKVNARLSEIPRPGRCSIP-------VMDPFKRKKAPARVSVIDPSG 344

                         250       260       270
                  ....*....|....*....|....*....|.
gi 568946421  299 TEARSSAcacpTSLGSSScTPASTPVALGTL 329
Cdd:COG5236   345 GNARAPM----AHRGGSR-QDTASPSTEAEL 370
 
Name Accession Description Interval E-value
SANT_MTA3_like cd11661
Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family ...
 1120-1163 9.61e-12

Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family include domains found in mouse metastasis-associated protein 3 (MTA3) proteins and arginine-glutamic dipeptide (RERE) repeats proteins. SANT (SWI3, ADA2, N-CoR and TFIIIB) DNA-binding domains are a diverse set of proteins that share a common 3 alpha-helix bundle. MTA3 has been shown to interact with nucleosome remodeling and deacetylase (NuRD) proteins CHD4 and HDAC1, and the core cohesin complex protein RAD21 in the ovary, and regulate G2/M progression in proliferating granulosa cells. RERE belongs to the atrophin family and has been identified as a nuclear receptor corepressor; altered expression levels of RERE are associated with cancer in humans while mutations of Rere in mice cause failure in closing the anterior neural tube and fusion of the telencephalic and optic vesicles during embryogenesis.


Pssm-ID: 212559 [Multi-domain]  Cd Length: 46  Bit Score: 60.71  E-value: 9.61e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 568946421 1120 WTPMEKRLFKKAFCAHKKDFYLIHK-MIQTKSVAQCVEYYYIWKK 1163
Cdd:cd11661     2 WSESEAKLFEEGLRKYGKDFHDIRQdFLPWKSVGELVEFYYMWKK 46
ELM2 pfam01448
ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown ...
 1010-1065 5.57e-11

ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown function. It is found in the MTA1 protein that is part of the NuRD complex. The domain is usually found to the N terminus of a myb-like DNA binding domain pfam00249. ELM2 is also found associated with an ARID DNA binding domain pfam01388 in Swiss:O82364. This suggests that ELM2 may also be involved in DNA binding, or perhaps is a protein-protein interaction domain.


Pssm-ID: 460214  Cd Length: 53  Bit Score: 58.78  E-value: 5.57e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 568946421  1010 INVGSRFQAEIPELQERLLA--RVDENVASLVWKPwgdvmTNPETQDRVMELCNVACS 1065
Cdd:pfam01448    1 IRVGPRYQAEIPELLPPSEEedRYEEEDELLVWDP-----NHNLPDRKLDEYLVVARS 53
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
1120-1164 2.05e-05

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 42.98  E-value: 2.05e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 568946421   1120 WTPMEKRLFKKAFCAH-KKDFYLIHKMIQTKSVAQCVEYYYIWKKM 1164
Cdd:smart00717    4 WTEEEDELLIELVKKYgKNNWEKIAKELPGRTAEQCRERWRNLLKP 49
PHA03247 PHA03247
large tegument protein UL36; Provisional
 231-677 4.57e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.40  E-value: 4.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946421  231 PEEEAYGDPTHNHDVANQP--PPSGLRSLGPPEARSPGSVLPNRDllrcivssivhQKIPSPGPAVGPSDTEARSSACAC 308
Cdd:PHA03247 2577 PSEPAVTSRARRPDAPPQSarPRAPVDDRGDPRGPAPPSPLPPDT-----------HAPDPPPPSPSPAANEPDPHPPPT 2645

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946421  309 PTSLGSSSCTPASTPVALGTLGSEIPEETHP------PRKEAATEVFTPVQSRAAENGVPDPPESELESESPRLQRP--- 379
Cdd:PHA03247 2646 VPPPERPRDDPAPGRVSRPRRARRLGRAAQAssppqrPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPpgp 2725

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946421  380 -SSLEGWPEGSSLPACLPLFRGHSVPSGSQPSSHnfqwlRNLPGCPKNKGSNVFMVHKPPAVASREGSEGGGSGPSSTPT 458
Cdd:PHA03247 2726 aAARQASPALPAAPAPPAVPAGPATPGGPARPAR-----PPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPS 2800

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946421  459 SVEPSPslgttqeellpfPPALLKAPGEA-SSEVRQAAGEDETWAPKKCKPDCESFPWQSPTELGLQDAqnPGGlPSDAT 537
Cdd:PHA03247 2801 PWDPAD------------PPAAVLAPAAAlPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVA--PGG-DVRRR 2865

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946421  538 PLFRQLFMKSQESlvSHEQMQVLQMIAKSQRIFSHTQVATASAQRPGPEGKQSTLKPLQGPWPPQTLPPAPTvdsfqigP 617
Cdd:PHA03247 2866 PPSRSPAAKPAAP--ARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPP-------P 2936

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946421  618 GHSEPEGSPvrrrKTMPAVSRETSPGGPRRDTKGGPKVASAPPSLTGPGLLPSRNPDSSS 677
Cdd:PHA03247 2937 PRPQPPLAP----TTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASS 2992
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 1120-1162 1.09e-04

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 40.95  E-value: 1.09e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 568946421  1120 WTPMEKRLFKKAFCAHKKDFYLIHKMIQTKSVAQCVEYYYIWK 1162
Cdd:pfam00249    4 WTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 168-190 1.86e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 39.59  E-value: 1.86e-04
                           10        20
                   ....*....|....*....|...
gi 568946421   168 HVCKVCSKAFKRQDHLTGHMLTH 190
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5236 COG5236
Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];
80-329 3.64e-04

Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];


Pssm-ID: 227561 [Multi-domain]  Cd Length: 493  Bit Score: 44.63  E-value: 3.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946421   80 GKDSDSVKLLEE-----YADSESQTSLQDLGlgALKVPKEADEggRATGSTRKGKRQHSSPQNPLLdCSLCG---KVFS- 150
Cdd:COG5236   120 ITDRRQWKGREEkvgifYEGEDVRDEMEDLL--SFKCPKSKCH--RRCGSLKELKKHYKAQHGFVL-CSECIgnkKDFWn 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946421  151 -----SASSLSKHYLTHSQE---RKHV-CKVCSKAFKRQDHLTGHM-LTHQKTkpFVCIEQGCSKS--YCDYRSLRRHYE 218
Cdd:COG5236   195 eirlfRSSTLRDHKNGGLEEegfKGHPlCIFCKIYFYDDDELRRHCrLRHEAC--HICDMVGPIRYqyFKSYEDLEAHFR 272

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946421  219 VQHGVCILkETPPEEEAYGDPTHNHDVANQPPPSGLRSLGPPEARSPGSVLPnrdllrcIVSSIVHQKIPSPGPAVGPSD 298
Cdd:COG5236   273 NAHYCCTF-QTCRVGKCYVFPYHTELLEHLTRFHKVNARLSEIPRPGRCSIP-------VMDPFKRKKAPARVSVIDPSG 344

                         250       260       270
                  ....*....|....*....|....*....|.
gi 568946421  299 TEARSSAcacpTSLGSSScTPASTPVALGTL 329
Cdd:COG5236   345 GNARAPM----AHRGGSR-QDTASPSTEAEL 370
PHA00733 PHA00733
hypothetical protein
 142-187 1.11e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 40.24  E-value: 1.11e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 568946421  142 CSLCGKVFSSASSLSKH--YLTHSQerkhVCKVCSKAFKRQDHLTGHM 187
Cdd:PHA00733   76 CPLCLMPFSSSVSLKQHirYTEHSK----VCPVCGKEFRNTDSTLDHV 119
 
Name Accession Description Interval E-value
SANT_MTA3_like cd11661
Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family ...
 1120-1163 9.61e-12

Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family include domains found in mouse metastasis-associated protein 3 (MTA3) proteins and arginine-glutamic dipeptide (RERE) repeats proteins. SANT (SWI3, ADA2, N-CoR and TFIIIB) DNA-binding domains are a diverse set of proteins that share a common 3 alpha-helix bundle. MTA3 has been shown to interact with nucleosome remodeling and deacetylase (NuRD) proteins CHD4 and HDAC1, and the core cohesin complex protein RAD21 in the ovary, and regulate G2/M progression in proliferating granulosa cells. RERE belongs to the atrophin family and has been identified as a nuclear receptor corepressor; altered expression levels of RERE are associated with cancer in humans while mutations of Rere in mice cause failure in closing the anterior neural tube and fusion of the telencephalic and optic vesicles during embryogenesis.


Pssm-ID: 212559 [Multi-domain]  Cd Length: 46  Bit Score: 60.71  E-value: 9.61e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 568946421 1120 WTPMEKRLFKKAFCAHKKDFYLIHK-MIQTKSVAQCVEYYYIWKK 1163
Cdd:cd11661     2 WSESEAKLFEEGLRKYGKDFHDIRQdFLPWKSVGELVEFYYMWKK 46
ELM2 pfam01448
ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown ...
 1010-1065 5.57e-11

ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown function. It is found in the MTA1 protein that is part of the NuRD complex. The domain is usually found to the N terminus of a myb-like DNA binding domain pfam00249. ELM2 is also found associated with an ARID DNA binding domain pfam01388 in Swiss:O82364. This suggests that ELM2 may also be involved in DNA binding, or perhaps is a protein-protein interaction domain.


Pssm-ID: 460214  Cd Length: 53  Bit Score: 58.78  E-value: 5.57e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 568946421  1010 INVGSRFQAEIPELQERLLA--RVDENVASLVWKPwgdvmTNPETQDRVMELCNVACS 1065
Cdd:pfam01448    1 IRVGPRYQAEIPELLPPSEEedRYEEEDELLVWDP-----NHNLPDRKLDEYLVVARS 53
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
1120-1164 2.05e-05

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 42.98  E-value: 2.05e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 568946421   1120 WTPMEKRLFKKAFCAH-KKDFYLIHKMIQTKSVAQCVEYYYIWKKM 1164
Cdd:smart00717    4 WTEEEDELLIELVKKYgKNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 1120-1162 2.68e-05

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 42.56  E-value: 2.68e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 568946421 1120 WTPMEKRLFKKAFCAH-KKDFYLIHKMIQTKSVAQCVEYYYIWK 1162
Cdd:cd00167     2 WTEEEDELLLEAVKKYgKNNWEKIAKELPGRTPKQCRERWRNLL 45
PHA03247 PHA03247
large tegument protein UL36; Provisional
 231-677 4.57e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.40  E-value: 4.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946421  231 PEEEAYGDPTHNHDVANQP--PPSGLRSLGPPEARSPGSVLPNRDllrcivssivhQKIPSPGPAVGPSDTEARSSACAC 308
Cdd:PHA03247 2577 PSEPAVTSRARRPDAPPQSarPRAPVDDRGDPRGPAPPSPLPPDT-----------HAPDPPPPSPSPAANEPDPHPPPT 2645

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946421  309 PTSLGSSSCTPASTPVALGTLGSEIPEETHP------PRKEAATEVFTPVQSRAAENGVPDPPESELESESPRLQRP--- 379
Cdd:PHA03247 2646 VPPPERPRDDPAPGRVSRPRRARRLGRAAQAssppqrPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPpgp 2725

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946421  380 -SSLEGWPEGSSLPACLPLFRGHSVPSGSQPSSHnfqwlRNLPGCPKNKGSNVFMVHKPPAVASREGSEGGGSGPSSTPT 458
Cdd:PHA03247 2726 aAARQASPALPAAPAPPAVPAGPATPGGPARPAR-----PPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPS 2800

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946421  459 SVEPSPslgttqeellpfPPALLKAPGEA-SSEVRQAAGEDETWAPKKCKPDCESFPWQSPTELGLQDAqnPGGlPSDAT 537
Cdd:PHA03247 2801 PWDPAD------------PPAAVLAPAAAlPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVA--PGG-DVRRR 2865

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946421  538 PLFRQLFMKSQESlvSHEQMQVLQMIAKSQRIFSHTQVATASAQRPGPEGKQSTLKPLQGPWPPQTLPPAPTvdsfqigP 617
Cdd:PHA03247 2866 PPSRSPAAKPAAP--ARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPP-------P 2936

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946421  618 GHSEPEGSPvrrrKTMPAVSRETSPGGPRRDTKGGPKVASAPPSLTGPGLLPSRNPDSSS 677
Cdd:PHA03247 2937 PRPQPPLAP----TTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASS 2992
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 1120-1162 1.09e-04

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 40.95  E-value: 1.09e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 568946421  1120 WTPMEKRLFKKAFCAHKKDFYLIHKMIQTKSVAQCVEYYYIWK 1162
Cdd:pfam00249    4 WTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 168-190 1.86e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 39.59  E-value: 1.86e-04
                           10        20
                   ....*....|....*....|...
gi 568946421   168 HVCKVCSKAFKRQDHLTGHMLTH 190
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5236 COG5236
Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];
80-329 3.64e-04

Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];


Pssm-ID: 227561 [Multi-domain]  Cd Length: 493  Bit Score: 44.63  E-value: 3.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946421   80 GKDSDSVKLLEE-----YADSESQTSLQDLGlgALKVPKEADEggRATGSTRKGKRQHSSPQNPLLdCSLCG---KVFS- 150
Cdd:COG5236   120 ITDRRQWKGREEkvgifYEGEDVRDEMEDLL--SFKCPKSKCH--RRCGSLKELKKHYKAQHGFVL-CSECIgnkKDFWn 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946421  151 -----SASSLSKHYLTHSQE---RKHV-CKVCSKAFKRQDHLTGHM-LTHQKTkpFVCIEQGCSKS--YCDYRSLRRHYE 218
Cdd:COG5236   195 eirlfRSSTLRDHKNGGLEEegfKGHPlCIFCKIYFYDDDELRRHCrLRHEAC--HICDMVGPIRYqyFKSYEDLEAHFR 272

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946421  219 VQHGVCILkETPPEEEAYGDPTHNHDVANQPPPSGLRSLGPPEARSPGSVLPnrdllrcIVSSIVHQKIPSPGPAVGPSD 298
Cdd:COG5236   273 NAHYCCTF-QTCRVGKCYVFPYHTELLEHLTRFHKVNARLSEIPRPGRCSIP-------VMDPFKRKKAPARVSVIDPSG 344

                         250       260       270
                  ....*....|....*....|....*....|.
gi 568946421  299 TEARSSAcacpTSLGSSScTPASTPVALGTL 329
Cdd:COG5236   345 GNARAPM----AHRGGSR-QDTASPSTEAEL 370
PHA00733 PHA00733
hypothetical protein
 142-187 1.11e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 40.24  E-value: 1.11e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 568946421  142 CSLCGKVFSSASSLSKH--YLTHSQerkhVCKVCSKAFKRQDHLTGHM 187
Cdd:PHA00733   76 CPLCLMPFSSSVSLKQHirYTEHSK----VCPVCGKEFRNTDSTLDHV 119
zf-C2H2_6 pfam13912
C2H2-type zinc finger;
168-192 1.47e-03

C2H2-type zinc finger;


Pssm-ID: 433576  Cd Length: 27  Bit Score: 37.22  E-value: 1.47e-03
                           10        20
                   ....*....|....*....|....*
gi 568946421   168 HVCKVCSKAFKRQDHLTGHMLTHQK 192
Cdd:pfam13912    2 HECSECGKSFPSYQALGGHKKSHRK 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
150-216 1.66e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.38  E-value: 1.66e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568946421  150 SSASSLSKHYLTHSQERKHVCKVCSKAFKRQDHLTGHMLTHQKTKPFVCIEQGCSKSYCDYRSLRRH 216
Cdd:COG5048    16 LSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRH 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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