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Conserved domains on  [gi|568947320|ref|XP_006540685|]
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growth arrest-specific protein 2 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CH_SF super family cl00030
calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding ...
 30-191 2.84e-93

calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding motifs, which may be present as a single copy or in tandem repeats (which increase binding affinity). They either function as autonomous actin binding motifs or serve a regulatory function. CH domains are found in cytoskeletal and signal transduction proteins, including actin-binding proteins like spectrin, alpha-actinin, dystrophin, utrophin, and fimbrin, as well as proteins essential for regulation of cell shape (cortexillins), and signaling proteins (Vav).


The actual alignment was detected with superfamily member cd21267:

Pssm-ID: 469584  Cd Length: 136  Bit Score: 273.74  E-value: 2.84e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947320  30 HEANLLPMKEDLALWLTNLLGKEITAETFMEKLDNGALLCQLAATVQEKFKESMDANKPAkphsphfeagfyltskmtqn 109
Cdd:cd21267    1 HEASLLPMKEDLALWLTNLLGKEITAESFMEKLDNGALLCQLAETLQEKFKENSADANKP-------------------- 60

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947320 110 ptsslsSKTLPLKKIPCKASAPSGSFFARDNTANFLSWCRDLGVDETCLFESEGLVLHKQPREVCLCLLELGRIAARYGV 189
Cdd:cd21267   61 ------GKSLPVRKIPCRANAPSGSFFARDNTANFLSWCRDVGVGDTCLFESEGLVLHKQPREVCLCLLELGRIAARFGV 134


                 ..
gi 568947320 190 EP 191
Cdd:cd21267  135 EP 136
GAS2 smart00243
Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain
 228-301 1.53e-37

Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain


:

Pssm-ID: 128539  Cd Length: 73  Bit Score: 129.11  E-value: 1.53e-37
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568947320   228 NLLDDAVKRISEDppCKCPTKFCVERLSQGRYRVG-EKILFIRMLHNKHVMVRVGGGWETFAGYLLKHDPCRMLQ 301
Cdd:smart00243   1 DKIDDEVKRIVED--CKCPTKFQVEKISEGKYRFGdSQILRLVRILRSTVMVRVGGGWETLDEYLLKHDPCRAKG 73
 
Name Accession Description Interval E-value
CH_GAS2 cd21267
calponin homology (CH) domain found in growth arrest-specific protein 2; Growth ...
 30-191 2.84e-93

calponin homology (CH) domain found in growth arrest-specific protein 2; Growth arrest-specific protein 2 (GAS-2) may play a role in apoptosis by acting as a cell death substrate for caspases. It contains a single copy of the CH domain at the N-terminal region. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409116  Cd Length: 136  Bit Score: 273.74  E-value: 2.84e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947320  30 HEANLLPMKEDLALWLTNLLGKEITAETFMEKLDNGALLCQLAATVQEKFKESMDANKPAkphsphfeagfyltskmtqn 109
Cdd:cd21267    1 HEASLLPMKEDLALWLTNLLGKEITAESFMEKLDNGALLCQLAETLQEKFKENSADANKP-------------------- 60

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947320 110 ptsslsSKTLPLKKIPCKASAPSGSFFARDNTANFLSWCRDLGVDETCLFESEGLVLHKQPREVCLCLLELGRIAARYGV 189
Cdd:cd21267   61 ------GKSLPVRKIPCRANAPSGSFFARDNTANFLSWCRDVGVGDTCLFESEGLVLHKQPREVCLCLLELGRIAARFGV 134


                 ..
gi 568947320 190 EP 191
Cdd:cd21267  135 EP 136
GAS2 smart00243
Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain
 228-301 1.53e-37

Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain


Pssm-ID: 128539  Cd Length: 73  Bit Score: 129.11  E-value: 1.53e-37
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568947320   228 NLLDDAVKRISEDppCKCPTKFCVERLSQGRYRVG-EKILFIRMLHNKHVMVRVGGGWETFAGYLLKHDPCRMLQ 301
Cdd:smart00243   1 DKIDDEVKRIVED--CKCPTKFQVEKISEGKYRFGdSQILRLVRILRSTVMVRVGGGWETLDEYLLKHDPCRAKG 73
GAS2 pfam02187
Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members ...
 230-299 1.51e-36

Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members and Gas2 family members. The GAR domain comprises around 57 amino acids and has been shown to bind to microtubules.


Pssm-ID: 460480  Cd Length: 69  Bit Score: 126.17  E-value: 1.51e-36
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568947320  230 LDDAVKRISEDppCKCPTKFCVERLSQGRYRVGE--KILFIRMLHnKHVMVRVGGGWETFAGYLLKHDPCRM 299
Cdd:pfam02187   1 LDDEVRRIVAQ--CTCPTKFPVEKVGEGKYRFGDsqKLVFVRILR-SHVMVRVGGGWDTLEEYLLKHDPCRA 69
CH smart00033
Calponin homology domain; Actin binding domains present in duplicate at the N-termini of ...
 39-180 3.19e-06

Calponin homology domain; Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p.


Pssm-ID: 214479 [Multi-domain]  Cd Length: 101  Bit Score: 45.00  E-value: 3.19e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947320    39 EDLALWLTNLLGKEI--TAETFMEKLDNGALLCQLAATVQEKfkeSMDANKPakphsphfeagfyltskmtqnptsslss 116
Cdd:smart00033   1 KTLLRWVNSLLAEYDkpPVTNFSSDLKDGVALCALLNSLSPG---LVDKKKV---------------------------- 49

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568947320   117 ktlplkkipckaSAPSGSFFARDNTANFLSWCRDLGVDEtCLFESEGLVL-HKQPREVCLCLLEL 180
Cdd:smart00033  50 ------------AASLSRFKKIENINLALSFAEKLGGKV-VLFEPEDLVEgPKLILGVIWTLISL 101
SCP1 COG5199
Calponin [Cytoskeleton];
39-186 2.63e-04

Calponin [Cytoskeleton];


Pssm-ID: 227526 [Multi-domain]  Cd Length: 178  Bit Score: 41.06  E-value: 2.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947320  39 EDLALWLTNLLGKEITAE-TFMEKLDNGALLCQL---AATVQEKFKESmdankpakphsphfeagfyltskmtqnptssl 114
Cdd:COG5199   16 KEVTLWIETVLGEKFEPPgDLLSLLKDGVRLCRIlneASPLDIKYKES-------------------------------- 63

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568947320 115 ssktlplkKIPckasapsgsFFARDNTANFLSWCRDLGVDETCLFESEGLVLHKQPREVCLCLLELGRIAAR 186
Cdd:COG5199   64 --------KMP---------FVQMENISSFINGLKKLRVPEYELFQTNDLFEAKDLRQVVICLYSLSRYAQK 118
 
Name Accession Description Interval E-value
CH_GAS2 cd21267
calponin homology (CH) domain found in growth arrest-specific protein 2; Growth ...
 30-191 2.84e-93

calponin homology (CH) domain found in growth arrest-specific protein 2; Growth arrest-specific protein 2 (GAS-2) may play a role in apoptosis by acting as a cell death substrate for caspases. It contains a single copy of the CH domain at the N-terminal region. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409116  Cd Length: 136  Bit Score: 273.74  E-value: 2.84e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947320  30 HEANLLPMKEDLALWLTNLLGKEITAETFMEKLDNGALLCQLAATVQEKFKESMDANKPAkphsphfeagfyltskmtqn 109
Cdd:cd21267    1 HEASLLPMKEDLALWLTNLLGKEITAESFMEKLDNGALLCQLAETLQEKFKENSADANKP-------------------- 60

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947320 110 ptsslsSKTLPLKKIPCKASAPSGSFFARDNTANFLSWCRDLGVDETCLFESEGLVLHKQPREVCLCLLELGRIAARYGV 189
Cdd:cd21267   61 ------GKSLPVRKIPCRANAPSGSFFARDNTANFLSWCRDVGVGDTCLFESEGLVLHKQPREVCLCLLELGRIAARFGV 134


                 ..
gi 568947320 190 EP 191
Cdd:cd21267  135 EP 136
CH_GAS2L3 cd21269
calponin homology (CH) domain found in growth arrest-specific protein 2-like 3; Growth ...
 31-188 7.97e-69

calponin homology (CH) domain found in growth arrest-specific protein 2-like 3; Growth arrest-specific protein 2-like 3 (GAS2L3), also called GAS2-like protein 3, is a cytoskeletal linker protein that may promote and stabilize the formation of the actin and microtubule network. It contains a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409118  Cd Length: 130  Bit Score: 211.24  E-value: 7.97e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947320  31 EANLLPMKEDLALWLTNLLGKEITAETFMEKLDNGALLCQLAATVQEKFKESMDANkpakphsphfeagfyltskmtqnp 110
Cdd:cd21269    1 EATLVPMQEDLSIWLSGMLGKEVKAERFMEELDNGVLLCQLIGVLQSKIKECCSTE------------------------ 56

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568947320 111 tsslSSKTLPLKKIPCKASAPSGSFFARDNTANFLSWCRDLGVDETCLFESEGLVLHKQPREVCLCLLELGRIAARYG 188
Cdd:cd21269   57 ----ELKHFPMRKVPCKKDAPSGSFFARDNTANFLSWCRAIGVDETYLFESEGLVLHKDPRQVCLCLLEIGRIVSRYG 130
CH_GAS2-like cd21204
calponin homology (CH) domain found in the growth arrest-specific protein 2 family; The growth ...
 31-188 2.73e-66

calponin homology (CH) domain found in the growth arrest-specific protein 2 family; The growth arrest-specific protein 2 (GAS-2) family includes GAS-2, and GAS-2 like proteins, GAS2L1-3. GAS-2 may play a role in apoptosis by acting as a cell death substrate for caspases. GAS2L1 (also called GAS2-related protein on chromosome 22 or growth arrest-specific protein 2-like 1) and GAS2L2 (also called GAS2-related protein on chromosome 17 or growth arrest-specific protein 2-like 2) may be involved in the cross-linking of microtubules and microfilaments. GAS2L3, also called GAS2-like protein 3, is a cytoskeletal linker protein that may promote and stabilize the formation of the actin and microtubule network. Members of this family contain a single copy of the CH domain at the N-terminal region. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409053  Cd Length: 131  Bit Score: 204.81  E-value: 2.73e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947320  31 EANLLPMKEDLALWLTNLLGKEITAETFMEKLDNGALLCQLAATVQEKFKESMDANKPAKPhsphfeagfyltskmtqnp 110
Cdd:cd21204    1 EEALLPMKEDLAEWLNDLLGDDLTPDNFLDELRNGVVLCQLAQKIQEAAEKAREAGKKNGP------------------- 61

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568947320 111 tsslssktLPLKKIPCKASAPSGSFFARDNTANFLSWCRDLGVDETCLFESEGLVLHKQPREVCLCLLELGRIAARYG 188
Cdd:cd21204   62 --------PPSYKLKCNENAKPGSFFARDNVANFLRWCRKLGVDEVLLFESEDLVLHKNPRQVLLCLLELARIAARYG 131
CH_GAS2L1_2 cd21268
calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar ...
 31-189 6.36e-40

calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar proteins; This subfamily includes GAS2L1 (also called GAS2-related protein on chromosome 22 or growth arrest-specific protein 2-like 1) and GAS2L2 (also called GAS2-related protein on chromosome 17 or growth arrest-specific protein 2-like 2). They may be involved in the cross-linking of microtubules and microfilaments. Members of this subfamily contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409117  Cd Length: 142  Bit Score: 137.45  E-value: 6.36e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947320  31 EANLLPMKEDLALWLTNLLGKEITAETFMEKLDNGALLCQLAATVQEKFKEsmdankpakphsphFEAgfyltskmtQNP 110
Cdd:cd21268    6 EEYLYAMKEDLAEWLNTLYNLDITADNFFEKLETGVLLCKHANNVTRAARE--------------FQA---------QHP 62

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947320 111 TSSLSSKTLPLKKIPCKASAPSGSFFARDNTANFLSWCR-DLGVDETCLFESEGLVLHKQPREVCLCLLELGRIAARYGV 189
Cdd:cd21268   63 ERASPLKLPPREVIFYRPSAKPGSFQARDNVSNFINWCRqLLGIPEVLLFETDDLVLRKNEKNFVLCLLEVARRGAKFGM 142
GAS2 smart00243
Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain
 228-301 1.53e-37

Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain


Pssm-ID: 128539  Cd Length: 73  Bit Score: 129.11  E-value: 1.53e-37
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568947320   228 NLLDDAVKRISEDppCKCPTKFCVERLSQGRYRVG-EKILFIRMLHNKHVMVRVGGGWETFAGYLLKHDPCRMLQ 301
Cdd:smart00243   1 DKIDDEVKRIVED--CKCPTKFQVEKISEGKYRFGdSQILRLVRILRSTVMVRVGGGWETLDEYLLKHDPCRAKG 73
GAS2 pfam02187
Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members ...
 230-299 1.51e-36

Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members and Gas2 family members. The GAR domain comprises around 57 amino acids and has been shown to bind to microtubules.


Pssm-ID: 460480  Cd Length: 69  Bit Score: 126.17  E-value: 1.51e-36
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568947320  230 LDDAVKRISEDppCKCPTKFCVERLSQGRYRVGE--KILFIRMLHnKHVMVRVGGGWETFAGYLLKHDPCRM 299
Cdd:pfam02187   1 LDDEVRRIVAQ--CTCPTKFPVEKVGEGKYRFGDsqKLVFVRILR-SHVMVRVGGGWDTLEEYLLKHDPCRA 69
CH_SF cd00014
calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding ...
 38-182 2.21e-10

calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding motifs, which may be present as a single copy or in tandem repeats (which increase binding affinity). They either function as autonomous actin binding motifs or serve a regulatory function. CH domains are found in cytoskeletal and signal transduction proteins, including actin-binding proteins like spectrin, alpha-actinin, dystrophin, utrophin, and fimbrin, as well as proteins essential for regulation of cell shape (cortexillins), and signaling proteins (Vav).


Pssm-ID: 409031 [Multi-domain]  Cd Length: 103  Bit Score: 56.96  E-value: 2.21e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947320  38 KEDLALWLTNLLGKEI--TAETFMEKLDNGALLCQLAatvqEKFkesmdankpakphSPhfeagfyltskmtqnptssls 115
Cdd:cd00014    1 EEELLKWINEVLGEELpvSITDLFESLRDGVLLCKLI----NKL-------------SP--------------------- 42

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568947320 116 sktlplKKIPCKASAPSGSFFARDNTANFLSWCRDLGVDETCLFESEGLVLHKQPREVCLCLLELGR 182
Cdd:cd00014   43 ------GSIPKINKKPKSPFKKRENINLFLNACKKLGLPELDLFEPEDLYEKGNLKKVLGTLWALAL 103
CH_LMO7-like cd21208
calponin homology (CH) domain found in LIM domain only protein 7 and similar proteins; This ...
 44-185 2.07e-06

calponin homology (CH) domain found in LIM domain only protein 7 and similar proteins; This family includes LIM domain only protein 7 (LMO-7) and LIM and calponin homology domains-containing protein 1 (LIMCH1), and similar proteins. LMO-7, also called F-box only protein 20, or LOMP, is a transcription regulator for expression of many Emery-Dreifuss muscular dystrophy (EDMD)-relevant genes. It binds to alpha-actinin and AF6/afadin at adherens junctions for epithelial cell-cell adhesion. LIMCH1 acts as an actin stress fiber-associated protein that activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. It positively regulates actin stress fiber assembly and stabilizes focal adhesions, and therefore negatively regulates cell spreading and cell migration. Members of this family contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409057 [Multi-domain]  Cd Length: 119  Bit Score: 46.18  E-value: 2.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947320  44 WLTNLLGKEITAETFMEKLDNGALLCQLAATVqekfkesmdankpaKPHSphfeagfyltskmtqnptsslssktlpLKK 123
Cdd:cd21208    8 WIEAVTGKKFPSDDFRESLEDGILLCELINAI--------------KPGS---------------------------IKK 46

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568947320 124 IpckaSAPSGSFFARDNTANFLSWCRDLGVDETCLFES-----------EGLVLHK----QPREVCLCLLELGRIAA 185
Cdd:cd21208   47 I----NRLPTPIAGLDNLNLFLKACEDLGLKDSQLFDPtdlqdlsnrriATHVRKKederRLKNVAITLYWLGRAAR 119
CH smart00033
Calponin homology domain; Actin binding domains present in duplicate at the N-termini of ...
 39-180 3.19e-06

Calponin homology domain; Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p.


Pssm-ID: 214479 [Multi-domain]  Cd Length: 101  Bit Score: 45.00  E-value: 3.19e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947320    39 EDLALWLTNLLGKEI--TAETFMEKLDNGALLCQLAATVQEKfkeSMDANKPakphsphfeagfyltskmtqnptsslss 116
Cdd:smart00033   1 KTLLRWVNSLLAEYDkpPVTNFSSDLKDGVALCALLNSLSPG---LVDKKKV---------------------------- 49

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568947320   117 ktlplkkipckaSAPSGSFFARDNTANFLSWCRDLGVDEtCLFESEGLVL-HKQPREVCLCLLEL 180
Cdd:smart00033  50 ------------AASLSRFKKIENINLALSFAEKLGGKV-VLFEPEDLVEgPKLILGVIWTLISL 101
SCP1 COG5199
Calponin [Cytoskeleton];
39-186 2.63e-04

Calponin [Cytoskeleton];


Pssm-ID: 227526 [Multi-domain]  Cd Length: 178  Bit Score: 41.06  E-value: 2.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947320  39 EDLALWLTNLLGKEITAE-TFMEKLDNGALLCQL---AATVQEKFKESmdankpakphsphfeagfyltskmtqnptssl 114
Cdd:COG5199   16 KEVTLWIETVLGEKFEPPgDLLSLLKDGVRLCRIlneASPLDIKYKES-------------------------------- 63

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568947320 115 ssktlplkKIPckasapsgsFFARDNTANFLSWCRDLGVDETCLFESEGLVLHKQPREVCLCLLELGRIAAR 186
Cdd:COG5199   64 --------KMP---------FVQMENISSFINGLKKLRVPEYELFQTNDLFEAKDLRQVVICLYSLSRYAQK 118
CH_dMP20-like cd21207
calponin homology (CH) domain found in Drosophila melanogaster muscle-specific protein 20 ...
 36-182 4.03e-04

calponin homology (CH) domain found in Drosophila melanogaster muscle-specific protein 20 (dMP20) and similar domains; This subfamily contains Drosophila melanogaster muscle-specific protein 20 (dMP20), Echinococcus granulosus myophilin, Dictyostelium discoideum Rac guanine nucleotide exchange factor B (also called Trix), and similar proteins. dMP20 is present only in the synchronous muscles of D. melanogaster. It may be involved in the system linking the nerve impulse with the contraction or the relaxation process. Trix is involved in the regulation of the late steps of the endocytic pathway. dMP20 contains a single copy of the CH domain, while Trix (triple CH-domain array exchange factor) contains three, two type 3 CH domains which are included in this model, and one type 1 CH domain that is not included in this subfamily, but is part of the superfamily. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409056 [Multi-domain]  Cd Length: 107  Bit Score: 39.22  E-value: 4.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947320  36 PMKEDLAL-WLTNLLGKEI-TAETFMEKLDNGALLCQLAATVqekfkesmdankpaKPHSphfeagfyltskmtqnptss 113
Cdd:cd21207    4 PALEAEALdWIEAVTGEKLdDGKDYEDVLKDGVILCKLINIL--------------KPGS-------------------- 49

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568947320 114 lssktlpLKKIPCKAsapsGSFFARDNTANFLSWCRDLGVDETCLFESEGLVLHKQPREVCLCLLELGR 182
Cdd:cd21207   50 -------VKKINTSK----MAFKLMENIENFLTACKGYGVPKTDLFQTVDLYEKKNIPQVTNCLFALGR 107
CH_SCP1-like cd21210
calponin homology (CH) domain found in Saccharomyces cerevisiae transgelin (SCP1) and similar ...
 37-182 6.59e-04

calponin homology (CH) domain found in Saccharomyces cerevisiae transgelin (SCP1) and similar proteins; The family includes transgelins from Saccharomyces cerevisiae and Schizosaccharomyces pombe, which are also called SCP1 and STG1, respectively. Transgelin, also called calponin homolog 1, has actin-binding and actin-bundling activity. It stabilizes actin filaments against disassembly. Transgelin contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409059 [Multi-domain]  Cd Length: 101  Bit Score: 38.50  E-value: 6.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947320  37 MKEDLALWLTNLLGKEITAETFMEKLDNGALLCQLAATVqekfkesmdanKPAkphsphfEAGFYLTSKMtqnptsslss 116
Cdd:cd21210    1 AEQEAREWIEEVLGEKLAQGDLLDALKDGVVLCKLANRI-----------LPA-------DIRKYKESKM---------- 52

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568947320 117 ktlplkkipckasapsgSFFARDNTANFLSWCRDLGVDETCLFESEGLVLHKQPREVCLCLLELGR 182
Cdd:cd21210   53 -----------------PFVQMENISAFLNAARKLGVPENDLFQTVDLFERKNPAQVLQCLHALSR 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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