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Conserved domains on  [gi|568947602|ref|XP_006540820|]
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zinc finger protein 658 isoform X1 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
23-80 5.29e-24

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 95.74  E-value: 5.29e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 568947602    23 VSFEDVTVDFSQEEWRRLDSVQRHLYQDVMLEIYSHLLAVGYPVPSPGAIFRIKKRKE 80
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEE 58
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
493-887 7.47e-14

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.12  E-value: 7.47e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947602 493 KNSHRCSDCGKSFTYASQLKMHRRVHTGEKPYKCRDCGKSFTYSFTLN--VHRRIHKVEKPHKCSI-CGKALASKYQLEE 569
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLElsRHLRTHHNNPSDLNSKsLPLSNSKASSSSL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947602 570 HERIHTGEKPYVCTECGKGFHGRSGFLRHQITHTRDKPFVCHKCGKAFFQRSQLTSHQQTHTGEKPYTCHYCGKSFSHTS 649
Cdd:COG5048  111 SSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISS 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947602 650 QLTVHHRIHT----GERPYKcdycaKSFSNSSQLKEHLRIHT-GETPYACSECGKAFSRRSSLNLHTKIHTGEKHHICSE 724
Cdd:COG5048  191 NVSTSIPSSSenspLSSSYS-----IPSSSSDQNLENSSSSLpLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947602 725 CGKAFSQKSVLRTHQRIHTG-EKPYKCSDCGKALASKGQLRDHQR--IHTGE--KPYMCPE--CGKGFFGRSSLHRHQIT 797
Cdd:COG5048  266 PTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947602 798 HTKERPFVC--QKCGKTFIQKS-----ALTSHQQIHTGEKPYVC--PECGKGFYNKSSLPRHQMTHT--RGRSFVCQKCG 866
Cdd:COG5048  346 HTSISPAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLsfRPYNCKNPPCS 425

                        410       420
                 ....*....|....*....|.
gi 568947602 867 KAFLQKSVLKCHQRTHTCKKP 887
Cdd:COG5048  426 KSFNRHYNLIPHKKIHTNHAP 446
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
300-684 1.30e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 64.72  E-value: 1.30e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947602 300 PFVCHKCGEAF----LQKTEFASHQethPEKPYECPD--CGKSFSRTSNLQVHHRIHTGEKPYECRDCGKSFNNTS---- 369
Cdd:COG5048   33 PDSCPNCTDSFsrleHLTRHIRSHT---GEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKAssss 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947602 370 -------------------------QLKVHYRIHTGERPYVCPVC-GKAFKQKSILSTHETIHTGEKPYKCTVCGKLFSC 423
Cdd:COG5048  110 lsssssnsndnnllsshslppssrdPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLIS 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947602 424 TSR---LKVHYQIHMKEKPYECGDCGKAFKRKSSLTvHQKIHIRQTHHECSecgKTFNQKSELSTHQRLHLGKNSHRCSD 500
Cdd:COG5048  190 SNVstsIPSSSENSPLSSSYSIPSSSSDQNLENSSS-SLPLTTNSQLSPKS---LLSQSPSSLSSSDSSSSASESPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947602 501 CGKSFTYASQLKMHRRVHTG-EKPYKCRDCGKSFTYSFTLNVHRR--IHKVE--KPHKC--SICGKALASKYQLEEHERI 573
Cdd:COG5048  266 PTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILL 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947602 574 HTGEKPYVC--TECGKGFHGRSGFLRHQITHTR-----DKPFVC--HKCGKAFFQRSQLTSHQQTHTGEKPYTCH--YCG 642
Cdd:COG5048  346 HTSISPAKEklLNSSSKFSPLLNNEPPQSLQQYkdlknDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCS 425

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|..
gi 568947602 643 KSFSHTSQLTVHHRIHTGERPYKCDyCAKSFSNSSQLKEHLR 684
Cdd:COG5048  426 KSFNRHYNLIPHKKIHTNHAPLLCS-ILKSFRRDLDLSNHGK 466
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
23-80 5.29e-24

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 95.74  E-value: 5.29e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 568947602    23 VSFEDVTVDFSQEEWRRLDSVQRHLYQDVMLEIYSHLLAVGYPVPSPGAIFRIKKRKE 80
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEE 58
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 22-63 1.50e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 82.52  E-value: 1.50e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 568947602   22 LVSFEDVTVDFSQEEWRRLDSVQRHLYQDVMLEIYSHLLAVG 63
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 23-59 2.26e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 73.35  E-value: 2.26e-16
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 568947602  23 VSFEDVTVDFSQEEWRRLDSVQRHLYQDVMLEIYSHL 59
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
493-887 7.47e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.12  E-value: 7.47e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947602 493 KNSHRCSDCGKSFTYASQLKMHRRVHTGEKPYKCRDCGKSFTYSFTLN--VHRRIHKVEKPHKCSI-CGKALASKYQLEE 569
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLElsRHLRTHHNNPSDLNSKsLPLSNSKASSSSL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947602 570 HERIHTGEKPYVCTECGKGFHGRSGFLRHQITHTRDKPFVCHKCGKAFFQRSQLTSHQQTHTGEKPYTCHYCGKSFSHTS 649
Cdd:COG5048  111 SSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISS 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947602 650 QLTVHHRIHT----GERPYKcdycaKSFSNSSQLKEHLRIHT-GETPYACSECGKAFSRRSSLNLHTKIHTGEKHHICSE 724
Cdd:COG5048  191 NVSTSIPSSSenspLSSSYS-----IPSSSSDQNLENSSSSLpLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947602 725 CGKAFSQKSVLRTHQRIHTG-EKPYKCSDCGKALASKGQLRDHQR--IHTGE--KPYMCPE--CGKGFFGRSSLHRHQIT 797
Cdd:COG5048  266 PTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947602 798 HTKERPFVC--QKCGKTFIQKS-----ALTSHQQIHTGEKPYVC--PECGKGFYNKSSLPRHQMTHT--RGRSFVCQKCG 866
Cdd:COG5048  346 HTSISPAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLsfRPYNCKNPPCS 425

                        410       420
                 ....*....|....*....|.
gi 568947602 867 KAFLQKSVLKCHQRTHTCKKP 887
Cdd:COG5048  426 KSFNRHYNLIPHKKIHTNHAP 446
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
300-684 1.30e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 64.72  E-value: 1.30e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947602 300 PFVCHKCGEAF----LQKTEFASHQethPEKPYECPD--CGKSFSRTSNLQVHHRIHTGEKPYECRDCGKSFNNTS---- 369
Cdd:COG5048   33 PDSCPNCTDSFsrleHLTRHIRSHT---GEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKAssss 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947602 370 -------------------------QLKVHYRIHTGERPYVCPVC-GKAFKQKSILSTHETIHTGEKPYKCTVCGKLFSC 423
Cdd:COG5048  110 lsssssnsndnnllsshslppssrdPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLIS 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947602 424 TSR---LKVHYQIHMKEKPYECGDCGKAFKRKSSLTvHQKIHIRQTHHECSecgKTFNQKSELSTHQRLHLGKNSHRCSD 500
Cdd:COG5048  190 SNVstsIPSSSENSPLSSSYSIPSSSSDQNLENSSS-SLPLTTNSQLSPKS---LLSQSPSSLSSSDSSSSASESPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947602 501 CGKSFTYASQLKMHRRVHTG-EKPYKCRDCGKSFTYSFTLNVHRR--IHKVE--KPHKC--SICGKALASKYQLEEHERI 573
Cdd:COG5048  266 PTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILL 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947602 574 HTGEKPYVC--TECGKGFHGRSGFLRHQITHTR-----DKPFVC--HKCGKAFFQRSQLTSHQQTHTGEKPYTCH--YCG 642
Cdd:COG5048  346 HTSISPAKEklLNSSSKFSPLLNNEPPQSLQQYkdlknDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCS 425

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|..
gi 568947602 643 KSFSHTSQLTVHHRIHTGERPYKCDyCAKSFSNSSQLKEHLR 684
Cdd:COG5048  426 KSFNRHYNLIPHKKIHTNHAPLLCS-ILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
371-395 5.44e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 5.44e-04
                          10        20
                  ....*....|....*....|....*
gi 568947602  371 LKVHYRIHTGERPYVCPVCGKAFKQ 395
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
511-535 6.56e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 6.56e-04
                          10        20
                  ....*....|....*....|....*
gi 568947602  511 LKMHRRVHTGEKPYKCRDCGKSFTY 535
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 663-722 5.70e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.93  E-value: 5.70e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947602 663 PYKCDYCAKSFSNSSQLKEHLRIhtGETPYACSECGKAFSRRSSlnlhTKIHTGEKHHIC 722
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRY--TEHSKVCPVCGKEFRNTDS----TLDHVCKKHNIC 126
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
23-80 5.29e-24

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 95.74  E-value: 5.29e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 568947602    23 VSFEDVTVDFSQEEWRRLDSVQRHLYQDVMLEIYSHLLAVGYPVPSPGAIFRIKKRKE 80
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEE 58
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 22-63 1.50e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 82.52  E-value: 1.50e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 568947602   22 LVSFEDVTVDFSQEEWRRLDSVQRHLYQDVMLEIYSHLLAVG 63
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 23-59 2.26e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 73.35  E-value: 2.26e-16
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 568947602  23 VSFEDVTVDFSQEEWRRLDSVQRHLYQDVMLEIYSHL 59
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
493-887 7.47e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.12  E-value: 7.47e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947602 493 KNSHRCSDCGKSFTYASQLKMHRRVHTGEKPYKCRDCGKSFTYSFTLN--VHRRIHKVEKPHKCSI-CGKALASKYQLEE 569
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLElsRHLRTHHNNPSDLNSKsLPLSNSKASSSSL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947602 570 HERIHTGEKPYVCTECGKGFHGRSGFLRHQITHTRDKPFVCHKCGKAFFQRSQLTSHQQTHTGEKPYTCHYCGKSFSHTS 649
Cdd:COG5048  111 SSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISS 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947602 650 QLTVHHRIHT----GERPYKcdycaKSFSNSSQLKEHLRIHT-GETPYACSECGKAFSRRSSLNLHTKIHTGEKHHICSE 724
Cdd:COG5048  191 NVSTSIPSSSenspLSSSYS-----IPSSSSDQNLENSSSSLpLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947602 725 CGKAFSQKSVLRTHQRIHTG-EKPYKCSDCGKALASKGQLRDHQR--IHTGE--KPYMCPE--CGKGFFGRSSLHRHQIT 797
Cdd:COG5048  266 PTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947602 798 HTKERPFVC--QKCGKTFIQKS-----ALTSHQQIHTGEKPYVC--PECGKGFYNKSSLPRHQMTHT--RGRSFVCQKCG 866
Cdd:COG5048  346 HTSISPAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLsfRPYNCKNPPCS 425

                        410       420
                 ....*....|....*....|.
gi 568947602 867 KAFLQKSVLKCHQRTHTCKKP 887
Cdd:COG5048  426 KSFNRHYNLIPHKKIHTNHAP 446
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
382-817 1.26e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 74.35  E-value: 1.26e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947602 382 RPYVCPVCGKAFKQKSILSTHETIHTGEKPYKCTVCGKLFSCTSR--LKVHYQIHMKEKPYECGDCG---KAFKRKSSLT 456
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPleLSRHLRTHHNNPSDLNSKSLplsNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947602 457 VHQKIHIRQTHHECSECGKTFNQKSELSTHQRLHLGKNSHRcsDCGKSFT----YASQLKMHRRVHTGEKPYKCRDcgks 532
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLP--GNNSSSVntpqSNSLHPPLPANSLSKDPSSNLS---- 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947602 533 ftysftLNVHRRIHKVEKPHKCSICGKALASKYQLEEHERIHTGEKPYVCTECGKGFHGRSGFLRHQITHTRDKPFVCHK 612
Cdd:COG5048  186 ------LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASE 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947602 613 CGKAFFQRSQLTSHQQTHTGekpytchycgkSFSHTSQLTvhhrihtgerPYKCDYCAKSFSNSSQLKEHLR--IHTGE- 689
Cdd:COG5048  260 SPRSSLPTASSQSSSPNESD-----------SSSEKGFSL----------PIKSKQCNISFSRSSPLTRHLRsvNHSGEs 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947602 690 -TPYACSE--CGKAFSRRSSLNLHTKIHTGEKHHIC--SECGKAFSQKSVLRTHQRI--HTGEKPYKCSDCGKALASKGQ 762
Cdd:COG5048  319 lKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSETLSNSCIRNF 398

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568947602 763 LRDHQRI-----HTGEKPYMC--PECGKGFFGRSSLHRHQITHTKERPFVCQKCGKTFIQKS 817
Cdd:COG5048  399 KRDSNLSlhiitHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
300-684 1.30e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 64.72  E-value: 1.30e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947602 300 PFVCHKCGEAF----LQKTEFASHQethPEKPYECPD--CGKSFSRTSNLQVHHRIHTGEKPYECRDCGKSFNNTS---- 369
Cdd:COG5048   33 PDSCPNCTDSFsrleHLTRHIRSHT---GEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKAssss 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947602 370 -------------------------QLKVHYRIHTGERPYVCPVC-GKAFKQKSILSTHETIHTGEKPYKCTVCGKLFSC 423
Cdd:COG5048  110 lsssssnsndnnllsshslppssrdPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLIS 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947602 424 TSR---LKVHYQIHMKEKPYECGDCGKAFKRKSSLTvHQKIHIRQTHHECSecgKTFNQKSELSTHQRLHLGKNSHRCSD 500
Cdd:COG5048  190 SNVstsIPSSSENSPLSSSYSIPSSSSDQNLENSSS-SLPLTTNSQLSPKS---LLSQSPSSLSSSDSSSSASESPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947602 501 CGKSFTYASQLKMHRRVHTG-EKPYKCRDCGKSFTYSFTLNVHRR--IHKVE--KPHKC--SICGKALASKYQLEEHERI 573
Cdd:COG5048  266 PTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILL 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947602 574 HTGEKPYVC--TECGKGFHGRSGFLRHQITHTR-----DKPFVC--HKCGKAFFQRSQLTSHQQTHTGEKPYTCH--YCG 642
Cdd:COG5048  346 HTSISPAKEklLNSSSKFSPLLNNEPPQSLQQYkdlknDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCS 425

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|..
gi 568947602 643 KSFSHTSQLTVHHRIHTGERPYKCDyCAKSFSNSSQLKEHLR 684
Cdd:COG5048  426 KSFNRHYNLIPHKKIHTNHAPLLCS-ILKSFRRDLDLSNHGK 466
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 317-404 1.35e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.48  E-value: 1.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947602 317 ASHQETHPEKPYECP--DCGKSFSRTSNLQvHHRIHTGEKPyecrdcgKSFNNTSQLKvHYRIHTGERPYVCPVCGKAFK 394
Cdd:COG5189  339 SRMLKVKDGKPYKCPveGCNKKYKNQNGLK-YHMLHGHQNQ-------KLHENPSPEK-MNIFSAKDKPYRCEVCDKRYK 409

                         90
                 ....*....|
gi 568947602 395 QKSILSTHET 404
Cdd:COG5189  410 NLNGLKYHRK 419
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 515-605 2.06e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 2.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947602 515 RRVHTGEKPYKCR--DCGKSFTYSFTLNVHRRihkveKPHkcsiCGKALASKYQLEEHERIHTGEKPYVCTECGKGFHGR 592
Cdd:COG5189  341 MLKVKDGKPYKCPveGCNKKYKNQNGLKYHML-----HGH----QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNL 411

                         90
                 ....*....|...
gi 568947602 593 SGfLRHQITHTRD 605
Cdd:COG5189  412 NG-LKYHRKHSHD 423
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
800-873 3.48e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 3.48e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568947602 800 KERPFVCQKCGKTFIQKSALTSHQQIHTGEKPYVC--PECGKGFYNKSSLPRHQMTHTRGRSFVCQKCGKAFLQKS 873
Cdd:COG5048   30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKA 105
zf-H2C2_2 pfam13465
Zinc-finger double domain;
371-395 5.44e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 5.44e-04
                          10        20
                  ....*....|....*....|....*
gi 568947602  371 LKVHYRIHTGERPYVCPVCGKAFKQ 395
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
342-367 5.49e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 5.49e-04
                          10        20
                  ....*....|....*....|....*.
gi 568947602  342 NLQVHHRIHTGEKPYECRDCGKSFNN 367
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
511-535 6.56e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 6.56e-04
                          10        20
                  ....*....|....*....|....*
gi 568947602  511 LKMHRRVHTGEKPYKCRDCGKSFTY 535
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 352-430 1.14e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 1.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947602 352 GEKPYECR--DCGKSFNNTSQLKVHyRIHTGERPYVCPVCGKafkqksilSTHETIHTGEKPYKCTVCGKLFSCTSRLKV 429
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 .
gi 568947602 430 H 430
Cdd:COG5189  417 H 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
679-703 1.34e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.34e-03
                          10        20
                  ....*....|....*....|....*
gi 568947602  679 LKEHLRIHTGETPYACSECGKAFSR 703
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 380-468 1.57e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947602 380 GERPYVCPV--CGKAFKQKSILSTHEtIHTGEKPykctvcgKLFSCTSRLKvHYQIHMKEKPYECGDCGKAFKRKSSLtv 457
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYHM-LHGHQNQ-------KLHENPSPEK-MNIFSAKDKPYRCEVCDKRYKNLNGL-- 414

                         90
                 ....*....|.
gi 568947602 458 hqKIHIRQTHH 468
Cdd:COG5189  415 --KYHRKHSHD 423
zf-H2C2_2 pfam13465
Zinc-finger double domain;
763-785 1.80e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.80e-03
                          10        20
                  ....*....|....*....|...
gi 568947602  763 LRDHQRIHTGEKPYMCPECGKGF 785
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 772-850 2.44e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 2.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947602 772 GEKPYMCP--ECGKGFFGRSSL-----HRHQITHTKERPfvcqkcgktfiqksALTSHQQIHTGEKPYVCPECGKGFYNK 844
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLkyhmlHGHQNQKLHENP--------------SPEKMNIFSAKDKPYRCEVCDKRYKNL 411


                 ....*.
gi 568947602 845 SSLPRH 850
Cdd:COG5189  412 NGLKYH 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
623-647 2.57e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.57e-03
                          10        20
                  ....*....|....*....|....*
gi 568947602  623 LTSHQQTHTGEKPYTCHYCGKSFSH 647
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 328-350 2.96e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 2.96e-03
                          10        20
                  ....*....|....*....|...
gi 568947602  328 YECPDCGKSFSRTSNLQVHHRIH 350
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
567-589 3.25e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 3.25e-03
                          10        20
                  ....*....|....*....|...
gi 568947602  567 LEEHERIHTGEKPYVCTECGKGF 589
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
735-756 5.31e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 5.31e-03
                          10        20
                  ....*....|....*....|..
gi 568947602  735 LRTHQRIHTGEKPYKCSDCGKA 756
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKS 23
PHA00733 PHA00733
hypothetical protein
 663-722 5.70e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.93  E-value: 5.70e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947602 663 PYKCDYCAKSFSNSSQLKEHLRIhtGETPYACSECGKAFSRRSSlnlhTKIHTGEKHHIC 722
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRY--TEHSKVCPVCGKEFRNTDS----TLDHVCKKHNIC 126
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 636-658 5.77e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 5.77e-03
                          10        20
                  ....*....|....*....|...
gi 568947602  636 YTCHYCGKSFSHTSQLTVHHRIH 658
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
818-841 7.79e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 7.79e-03
                          10        20
                  ....*....|....*....|....
gi 568947602  818 ALTSHQQIHTGEKPYVCPECGKGF 841
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 440-462 1.00e-02

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 1.00e-02
                          10        20
                  ....*....|....*....|...
gi 568947602  440 YECGDCGKAFKRKSSLTVHQKIH 462
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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