|
Name |
Accession |
Description |
Interval |
E-value |
| Rad51C |
cd19492 |
RAD51C recombinase; RAD51C recombinase, a RAD51 paralog, plays an important role in DNA repair ... |
118-308 |
3.37e-85 |
|
RAD51C recombinase; RAD51C recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51C, together with the other RAD51 paralogs, RAD51B, RAD51D, XRCC3, and XRCC2, helps recruit RAD51 to the break site. Additionally, RAD51C acts as a mediator in the early steps of DNA damage signaling.
Pssm-ID: 410900 [Multi-domain] Cd Length: 172 Bit Score: 254.46 E-value: 3.37e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 118 MKTTEICGAPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFmvdrvvdlataciqhlqliaekhkgeehrkale 197
Cdd:cd19492 1 GKITEICGVPGVGKTQLCMQLAVNVQIPKCFGGLAGEAIYIDTEGSF--------------------------------- 47
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 198 dftldnilsHIYYFRCRDYTELLAQVYLLPDFLSEHSKVRLVIVDGIAFPFRHDLDDLSLRTRLLNGLAQQMISLANNHR 277
Cdd:cd19492 48 ---------NIHYFRVHDYVELLALINSLPKFLEDHPKVKLIVVDSIAFPFRHDFDDLAQRTRLLNGLAQLLHSLARQHN 118
|
170 180 190
....*....|....*....|....*....|....*
gi 578831209 278 LAVILTNQMTTKIDRN-QALLVPALG--WQH-CTS 308
Cdd:cd19492 119 LAVVLTNQVTTKISEDgQSQLVPALGesWSHaCTT 153
|
|
| recomb_radA |
TIGR02236 |
DNA repair and recombination protein RadA; This family consists exclusively of archaeal RadA ... |
21-291 |
3.98e-42 |
|
DNA repair and recombination protein RadA; This family consists exclusively of archaeal RadA protein, a homolog of bacterial RecA (TIGR02012), eukaryotic RAD51 (TIGR02239), and archaeal RadB (TIGR02237). This protein is involved in DNA repair and recombination. The member from Pyrococcus horikoshii contains an intein. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 131290 [Multi-domain] Cd Length: 310 Bit Score: 148.35 E-value: 3.98e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 21 PAVRVKLVSAGFQTAEELLEVKPSELSKEVGISKAEALETLQIIRRECltnkpryagtsESHKKCTALELLEQEHTQGFI 100
Cdd:TIGR02236 9 PATAEKLREAGYDTFEAIAVASPKELSEIAGISEGTAAKIIQAARKAA-----------DLGGFETADDVLERRKTIGKI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 101 ITFCSALDDILGGGVPLMKTTEICGAPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFMVDRVVDLAtaciqhl 180
Cdd:TIGR02236 78 TTGSKELDELLGGGIETQAITEVFGEFGSGKTQICHQLAVNVQLPEEKGGLGGKAVYIDTENTFRPERIMQMA------- 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 181 qliaekhkgeEHRKALEDFTLDNilshIYYFRCRDYTELLAQVYLLPDFLSEHSK-VRLVIVDGIAFPFRHDL---DDLS 256
Cdd:TIGR02236 151 ----------EARGLDPDEVLKN----IYVARAYNSNHQMLLVEKAEDLIKELNNpVKLLIVDSLTSHFRAEYvgrGALA 216
|
250 260 270
....*....|....*....|....*....|....*
gi 578831209 257 LRTRLLNGLAQQMISLANNHRLAVILTNQMTTKID 291
Cdd:TIGR02236 217 ERQQKLNKHLHDLLRLADLYNAAVVVTNQVMARPD 251
|
|
| radA |
PRK04301 |
DNA repair and recombination protein RadA; Validated |
10-291 |
4.19e-41 |
|
DNA repair and recombination protein RadA; Validated
Pssm-ID: 235273 [Multi-domain] Cd Length: 317 Bit Score: 146.18 E-value: 4.19e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 10 MQRDLVSFP-LSPAVRVKLVSAGFQTAEELLEVKPSELSKEVGISKAEALetlQIIR--RECLTnkpryAGTSEshkkcT 86
Cdd:PRK04301 4 KEKDLEDLPgVGPATAEKLREAGYDTVEAIAVASPKELSEAAGIGESTAA---KIIEaaREAAD-----IGGFE-----T 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 87 ALELLEQEHTQGFIITFCSALDDILGGGVPLMKTTEICGAPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFMV 166
Cdd:PRK04301 71 ALEVLERRKNVGKITTGSKELDELLGGGIETQSITEFYGEFGSGKTQICHQLAVNVQLPEEKGGLEGKAVYIDTEGTFRP 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 167 DRVVDLAtaciqhlqliaekhkgeEHRKALEDFTLDNilshIYYFRCR--DYTELLAQVylLPDFLSEHSKVRLVIVDGI 244
Cdd:PRK04301 151 ERIEQMA-----------------EALGLDPDEVLDN----IHVARAYnsDHQMLLAEK--AEELIKEGENIKLVIVDSL 207
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 578831209 245 AFPFRHD---LDDLSLRTRLLNGLAQQMISLANNHRLAVILTNQMTTKID 291
Cdd:PRK04301 208 TAHFRAEyvgRGNLAERQQKLNKHLHDLLRLADLYNAAVVVTNQVMARPD 257
|
|
| Rad51 |
pfam08423 |
Rad51; Rad51 is a DNA repair and recombination protein and is a homolog of the bacterial ... |
86-291 |
1.13e-34 |
|
Rad51; Rad51 is a DNA repair and recombination protein and is a homolog of the bacterial ATPase RecA protein.
Pssm-ID: 462471 [Multi-domain] Cd Length: 255 Bit Score: 127.42 E-value: 1.13e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 86 TALELLEQEHTQGFIITFCSALDDILGGGVPLMKTTEICGAPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFM 165
Cdd:pfam08423 5 TATELHQRRSELIQITTGSKELDKLLGGGIETGSITEIFGEFRTGKTQLCHTLCVTCQLPLEMGGGEGKALYIDTEGTFR 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 166 VDRVVDlataciqhlqlIAEKHK--GEEhrkaledfTLDNILShiyyfrCRDYT-----ELLAQvylLPDFLSEhSKVRL 238
Cdd:pfam08423 85 PERLVA-----------IAERYGldPED--------VLDNVAY------ARAYNsehqmQLLQQ---AAAMMSE-SRFAL 135
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 578831209 239 VIVDGIAFPFRHD---LDDLSLRTRLLNGLAQQMISLANNHRLAVILTNQMTTKID 291
Cdd:pfam08423 136 LIVDSATALYRTDfsgRGELAERQQHLAKFLRTLQRLADEFGVAVVITNQVVAQVD 191
|
|
| radB |
PRK09361 |
DNA repair and recombination protein RadB; Provisional |
100-291 |
2.83e-26 |
|
DNA repair and recombination protein RadB; Provisional
Pssm-ID: 236482 [Multi-domain] Cd Length: 225 Bit Score: 104.17 E-value: 2.83e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 100 IITFCSALDDILGGGVPLMKTTEICGAPGVGKTQLCMQLAVDVQIPEcfggvaGEAVFIDTEGsFMVDRVVDLATaciqh 179
Cdd:PRK09361 5 LPTGCKMLDELLGGGFERGTITQIYGPPGSGKTNICLQLAVEAAKNG------KKVIYIDTEG-LSPERFKQIAG----- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 180 lqliaekhkgeehrkalEDFtlDNILSHIYYFRCRDYTELLAQVYLLPDFLSEhsKVRLVIVDGIAFPFRHDLDDLSLRT 259
Cdd:PRK09361 73 -----------------EDF--EELLSNIIIFEPSSFEEQSEAIRKAEKLAKE--NVGLIVLDSATSLYRLELEDEEDNS 131
|
170 180 190
....*....|....*....|....*....|....*
gi 578831209 260 RLLNGLAQQM---ISLANNHRLAVILTNQMTTKID 291
Cdd:PRK09361 132 KLNRELGRQLthlLKLARKHDLAVVITNQVYSDID 166
|
|
| recomb_RAD51 |
TIGR02239 |
DNA repair protein RAD51; This eukaryotic sequence family consists of RAD51, a protein ... |
26-299 |
2.09e-22 |
|
DNA repair protein RAD51; This eukaryotic sequence family consists of RAD51, a protein involved in DNA homologous recombination and repair. It is similar in sequence the exclusively meiotic recombinase DMC1 (TIGR02238), to archaeal families RadA (TIGR02236) and RadB (TIGR02237), and to bacterial RecA (TIGR02012).
Pssm-ID: 274048 [Multi-domain] Cd Length: 316 Bit Score: 95.56 E-value: 2.09e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 26 KLVSAGFQTAEELLEVKPSELSKEVGISKAEALETLqiirrecltnkpryagtSESHKK-----CTALELLEQEHTQGFI 100
Cdd:TIGR02239 16 KLQEAGLHTVESVAYAPKKQLLEIKGISEAKADKIL-----------------AEAAKLvpmgfTTATEFHQRRQEVIQL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 101 ITFCSALDDILGGGVPLMKTTEICGAPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFMVDRVVDlataciqhl 180
Cdd:TIGR02239 79 TTGSKELDKLLGGGIETGSITEIFGEFRTGKTQLCHTLAVTCQLPIDQGGGEGKALYIDTEGTFRPERLLA--------- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 181 qlIAEKHK--GEEhrkaledfTLDNIlSHIYYFRCRDYTELLAQVYLLpdfLSEhSKVRLVIVDGIAFPFRHDLD---DL 255
Cdd:TIGR02239 150 --IAERYGlnPED--------VLDNV-AYARAYNTDHQLQLLQQAAAM---MSE-SRFALLIVDSATALYRTDFSgrgEL 214
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 578831209 256 SLRTRLLNGLAQQMISLANNHRLAVILTNQMTTKIDRNQALLVP 299
Cdd:TIGR02239 215 SARQMHLARFLRSLQRLADEFGVAVVITNQVVAQVDGAGSMFAG 258
|
|
| RAD55 |
COG0467 |
RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms]; |
107-288 |
1.62e-08 |
|
RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];
Pssm-ID: 440235 [Multi-domain] Cd Length: 221 Bit Score: 54.15 E-value: 1.62e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 107 LDDILGGGVPLMKTTEICGAPGVGKTQLCMQLAVDvqipecfGGVAGE-AVFIDTEGSfmVDRVVDLAtaciqhlqliae 185
Cdd:COG0467 9 LDELLGGGLPRGSSTLLSGPPGTGKTTLALQFLAE-------GLRRGEkGLYVSFEES--PEQLLRRA------------ 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 186 KHKGEEHRKALEDFTLdNILSHIYYFRCRDYTELLAQvylLPDFLSEHsKVRLVIVDGIAfPFRHDLDDLSLRTRLLNGL 265
Cdd:COG0467 68 ESLGLDLEEYIESGLL-RIIDLSPEELGLDLEELLAR---LREAVEEF-GAKRVVIDSLS-GLLLALPDPERLREFLHRL 141
|
170 180
....*....|....*....|...
gi 578831209 266 aqqmISLANNHRLAVILTNQMTT 288
Cdd:COG0467 142 ----LRYLKKRGVTTLLTSETGG 160
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Rad51C |
cd19492 |
RAD51C recombinase; RAD51C recombinase, a RAD51 paralog, plays an important role in DNA repair ... |
118-308 |
3.37e-85 |
|
RAD51C recombinase; RAD51C recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51C, together with the other RAD51 paralogs, RAD51B, RAD51D, XRCC3, and XRCC2, helps recruit RAD51 to the break site. Additionally, RAD51C acts as a mediator in the early steps of DNA damage signaling.
Pssm-ID: 410900 [Multi-domain] Cd Length: 172 Bit Score: 254.46 E-value: 3.37e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 118 MKTTEICGAPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFmvdrvvdlataciqhlqliaekhkgeehrkale 197
Cdd:cd19492 1 GKITEICGVPGVGKTQLCMQLAVNVQIPKCFGGLAGEAIYIDTEGSF--------------------------------- 47
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 198 dftldnilsHIYYFRCRDYTELLAQVYLLPDFLSEHSKVRLVIVDGIAFPFRHDLDDLSLRTRLLNGLAQQMISLANNHR 277
Cdd:cd19492 48 ---------NIHYFRVHDYVELLALINSLPKFLEDHPKVKLIVVDSIAFPFRHDFDDLAQRTRLLNGLAQLLHSLARQHN 118
|
170 180 190
....*....|....*....|....*....|....*
gi 578831209 278 LAVILTNQMTTKIDRN-QALLVPALG--WQH-CTS 308
Cdd:cd19492 119 LAVVLTNQVTTKISEDgQSQLVPALGesWSHaCTT 153
|
|
| RecA-like |
cd01393 |
RecA family; RecA is a bacterial enzyme which has roles in homologous recombination, DNA ... |
119-309 |
1.87e-44 |
|
RecA family; RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange. While prokaryotes have a single RecA protein, eukaryotes have multiple RecA homologs such as Rad51, DMC1 and Rad55/57. Archaea have the RecA-like homologs RadA and RadB.
Pssm-ID: 410881 [Multi-domain] Cd Length: 185 Bit Score: 150.58 E-value: 1.87e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 119 KTTEICGAPGVGKTQLCMQLAVDVQIPEcfggvaGEAVFIDTEGSFMVDRVVDLATACIQhlqliaekhkgeehrkalED 198
Cdd:cd01393 2 KITEIYGPPGSGKTQLALQLAANALLLG------GGVVWIDTEGAFPPSRLVQILEASPS------------------SE 57
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 199 FTLDNILSHIYYFRCRDYTELLAQVYLLPDFLSEHSKVRLVIVDGIAFPFRHDLDD-------LSLRTRLLNGLAQQMIS 271
Cdd:cd01393 58 LELAEALSRLLYFRPPDTLAHLLALDSLPESLFPPPNTSLVVVDSVSALFRKAFPRggdgdssSSLRARLLSQLARALQK 137
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 578831209 272 LANNHRLAVILTNQMTTKID--RNQALLVPALG--WQHCTSH 309
Cdd:cd01393 138 LAAQFNLAVVVTNQVTTKIRggSGASLVPPALGntWEHSVST 179
|
|
| XRCC3 |
cd19491 |
XRCC3 recombinase; XRCC3 (X-ray repair complementing defective repair in Chinese hamster cells ... |
107-293 |
6.73e-43 |
|
XRCC3 recombinase; XRCC3 (X-ray repair complementing defective repair in Chinese hamster cells 3) recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. XRCC3, together with the other RAD51 paralogs, RAD51B, RAD51C, RAD51D, and XRCC2, helps recruit RAD51 to the break site.
Pssm-ID: 410899 [Multi-domain] Cd Length: 250 Bit Score: 148.59 E-value: 6.73e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 107 LDDILGGGVPLMKTTEICGAPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFMVDRVVDLatACIQHLQLIAEK 186
Cdd:cd19491 1 LDELLGGGIPVGGITEIAGESGAGKTQLCLQLALTVQLPRELGGLGGGAVYICTESSFPSKRLQQL--ASSLPKRYHLEK 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 187 HKgeehrkaledftldNILSHIYYFRCRDYTELLAQV-YLLPDFLsEHSKVRLVIVDGIAFPFRHDLD----DLSLRTRL 261
Cdd:cd19491 79 AK--------------NFLDNIFVEHVADLETLEHCLnYQLPALL-ERGPIRLVVIDSIAALFRSEFDtsrsDLVERAKY 143
|
170 180 190
....*....|....*....|....*....|..
gi 578831209 262 LNGLAQQMISLANNHRLAVILTNQMTTKIDRN 293
Cdd:cd19491 144 LRRLADHLKRLADKYNLAVVVVNQVTDRFDSS 175
|
|
| recomb_radA |
TIGR02236 |
DNA repair and recombination protein RadA; This family consists exclusively of archaeal RadA ... |
21-291 |
3.98e-42 |
|
DNA repair and recombination protein RadA; This family consists exclusively of archaeal RadA protein, a homolog of bacterial RecA (TIGR02012), eukaryotic RAD51 (TIGR02239), and archaeal RadB (TIGR02237). This protein is involved in DNA repair and recombination. The member from Pyrococcus horikoshii contains an intein. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 131290 [Multi-domain] Cd Length: 310 Bit Score: 148.35 E-value: 3.98e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 21 PAVRVKLVSAGFQTAEELLEVKPSELSKEVGISKAEALETLQIIRRECltnkpryagtsESHKKCTALELLEQEHTQGFI 100
Cdd:TIGR02236 9 PATAEKLREAGYDTFEAIAVASPKELSEIAGISEGTAAKIIQAARKAA-----------DLGGFETADDVLERRKTIGKI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 101 ITFCSALDDILGGGVPLMKTTEICGAPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFMVDRVVDLAtaciqhl 180
Cdd:TIGR02236 78 TTGSKELDELLGGGIETQAITEVFGEFGSGKTQICHQLAVNVQLPEEKGGLGGKAVYIDTENTFRPERIMQMA------- 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 181 qliaekhkgeEHRKALEDFTLDNilshIYYFRCRDYTELLAQVYLLPDFLSEHSK-VRLVIVDGIAFPFRHDL---DDLS 256
Cdd:TIGR02236 151 ----------EARGLDPDEVLKN----IYVARAYNSNHQMLLVEKAEDLIKELNNpVKLLIVDSLTSHFRAEYvgrGALA 216
|
250 260 270
....*....|....*....|....*....|....*
gi 578831209 257 LRTRLLNGLAQQMISLANNHRLAVILTNQMTTKID 291
Cdd:TIGR02236 217 ERQQKLNKHLHDLLRLADLYNAAVVVTNQVMARPD 251
|
|
| radA |
PRK04301 |
DNA repair and recombination protein RadA; Validated |
10-291 |
4.19e-41 |
|
DNA repair and recombination protein RadA; Validated
Pssm-ID: 235273 [Multi-domain] Cd Length: 317 Bit Score: 146.18 E-value: 4.19e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 10 MQRDLVSFP-LSPAVRVKLVSAGFQTAEELLEVKPSELSKEVGISKAEALetlQIIR--RECLTnkpryAGTSEshkkcT 86
Cdd:PRK04301 4 KEKDLEDLPgVGPATAEKLREAGYDTVEAIAVASPKELSEAAGIGESTAA---KIIEaaREAAD-----IGGFE-----T 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 87 ALELLEQEHTQGFIITFCSALDDILGGGVPLMKTTEICGAPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFMV 166
Cdd:PRK04301 71 ALEVLERRKNVGKITTGSKELDELLGGGIETQSITEFYGEFGSGKTQICHQLAVNVQLPEEKGGLEGKAVYIDTEGTFRP 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 167 DRVVDLAtaciqhlqliaekhkgeEHRKALEDFTLDNilshIYYFRCR--DYTELLAQVylLPDFLSEHSKVRLVIVDGI 244
Cdd:PRK04301 151 ERIEQMA-----------------EALGLDPDEVLDN----IHVARAYnsDHQMLLAEK--AEELIKEGENIKLVIVDSL 207
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 578831209 245 AFPFRHD---LDDLSLRTRLLNGLAQQMISLANNHRLAVILTNQMTTKID 291
Cdd:PRK04301 208 TAHFRAEyvgRGNLAERQQKLNKHLHDLLRLADLYNAAVVVTNQVMARPD 257
|
|
| Rad51 |
pfam08423 |
Rad51; Rad51 is a DNA repair and recombination protein and is a homolog of the bacterial ... |
86-291 |
1.13e-34 |
|
Rad51; Rad51 is a DNA repair and recombination protein and is a homolog of the bacterial ATPase RecA protein.
Pssm-ID: 462471 [Multi-domain] Cd Length: 255 Bit Score: 127.42 E-value: 1.13e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 86 TALELLEQEHTQGFIITFCSALDDILGGGVPLMKTTEICGAPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFM 165
Cdd:pfam08423 5 TATELHQRRSELIQITTGSKELDKLLGGGIETGSITEIFGEFRTGKTQLCHTLCVTCQLPLEMGGGEGKALYIDTEGTFR 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 166 VDRVVDlataciqhlqlIAEKHK--GEEhrkaledfTLDNILShiyyfrCRDYT-----ELLAQvylLPDFLSEhSKVRL 238
Cdd:pfam08423 85 PERLVA-----------IAERYGldPED--------VLDNVAY------ARAYNsehqmQLLQQ---AAAMMSE-SRFAL 135
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 578831209 239 VIVDGIAFPFRHD---LDDLSLRTRLLNGLAQQMISLANNHRLAVILTNQMTTKID 291
Cdd:pfam08423 136 LIVDSATALYRTDfsgRGELAERQQHLAKFLRTLQRLADEFGVAVVITNQVVAQVD 191
|
|
| Rad51B |
cd19493 |
RAD51B recombinase; RAD51B recombinase, a RAD51 paralog, plays an important role in DNA repair ... |
108-306 |
2.42e-33 |
|
RAD51B recombinase; RAD51B recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51B, together with the other RAD51 paralogs, RAD51C, RAD51D, XRCC3, and XRCC2, helps recruit RAD51 to the break site.
Pssm-ID: 410901 [Multi-domain] Cd Length: 222 Bit Score: 122.81 E-value: 2.42e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 108 DDILGGGVPLMKTTEICGAPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFMVDRVVDLAtaciqhlqliAEKH 187
Cdd:cd19493 1 DTALAGGLPLGAITEITGASGSGKTQFALTLASSAAMPARKGGLDGGVLYIDTESKFSAERLAEIA----------EARF 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 188 KGEEHRKALEDFTLDNILSHIYYFRCRDYTELLAQVYLLPDFLSEHsKVRLVIVDGIAFPFRHD----LDDLSLRTRLLN 263
Cdd:cd19493 71 PEAFSGFMEENERAEEMLKRVAVVRVTTLAQLLERLPNLEEHILSS-GVRLVVIDSIAALVRREfggsDGEVTERHNALA 149
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 578831209 264 GLAQQMISLANNHRLAVILTNQMTTKIDRNQ---ALLVPALG--WQHC 306
Cdd:cd19493 150 REASSLKRLAEEFRIAVLVTNQATTHFGDAGdgsSGVTAALGdaWAHA 197
|
|
| DMC1 |
cd19514 |
homologous-pairing protein DMC1; DMC1 has a central role in homologous recombination in ... |
100-287 |
8.30e-31 |
|
homologous-pairing protein DMC1; DMC1 has a central role in homologous recombination in meiosis. It assembles at the sites of programmed DNA double-strand breaks and carries out a search for allelic DNA sequences located on homologous chromatids. It forms octameric rings.
Pssm-ID: 410922 [Multi-domain] Cd Length: 236 Bit Score: 116.69 E-value: 8.30e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 100 IITFCSALDDILGGGVPLMKTTEICGAPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFMVDRVVDlataciqh 179
Cdd:cd19514 1 ISTGSTELDKLLGGGIESMSITEVFGEFRTGKTQLSHTLCVTAQLPGSMGGGGGKVAYIDTEGTFRPDRIRP-------- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 180 lqlIAEKHkGEEHRKAledftLDNILshiyYFRCrdYT-----ELLAQVyllPDFLSEHSKVRLVIVDGIAFPFRHDLD- 253
Cdd:cd19514 73 ---IAERF-GVDHDAV-----LDNIL----YARA--YTsehqmELLDYV---AAKFHEEAVFRLLIIDSIMALFRVDFSg 134
|
170 180 190
....*....|....*....|....*....|....*.
gi 578831209 254 --DLSLRTRLLNGLAQQMISLANNHRLAVILTNQMT 287
Cdd:cd19514 135 rgELAERQQKLAQMLSRLQKISEEYNVAVFITNQVT 170
|
|
| archRadA |
cd19515 |
archaeal recombinase Rad51/RadA; This group includes the archaeal protein RadA which is a ... |
100-291 |
3.11e-30 |
|
archaeal recombinase Rad51/RadA; This group includes the archaeal protein RadA which is a homolog of Rad51. RAD51 recombinase plays an essential role in DNA repair by homologous recombination (HR)
Pssm-ID: 410923 [Multi-domain] Cd Length: 233 Bit Score: 115.15 E-value: 3.11e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 100 IITFCSALDDILGGGVPLMKTTEICGAPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFMVDRVVDLAtaciqh 179
Cdd:cd19515 1 ISTGSKELDKLLGGGIETQAITEVFGEFGSGKTQLCHQLAVNVQLPPEEGGLNGKAVYIDTENTFRPERIMQMA------ 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 180 lqliaeKHKGEEhrkaledftLDNILSHIYYFRCRDYTELLAQVYLLPDFLSEHSKVRLVIVDGIAFPFRHDL---DDLS 256
Cdd:cd19515 75 ------KALGLD---------PDEVLDNIYVARAYNSNHQMLLVEKAEDLIKEGNNIKLLIVDSLTSHFRAEYvgrGTLA 139
|
170 180 190
....*....|....*....|....*....|....*
gi 578831209 257 LRTRLLNGLAQQMISLANNHRLAVILTNQMTTKID 291
Cdd:cd19515 140 ERQQKLNKHLHDLHRLADLYNIAVLVTNQVMAKPD 174
|
|
| PTZ00035 |
PTZ00035 |
Rad51 protein; Provisional |
26-291 |
7.31e-29 |
|
Rad51 protein; Provisional
Pssm-ID: 185407 [Multi-domain] Cd Length: 337 Bit Score: 113.94 E-value: 7.31e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 26 KLVSAGFQTAEELLEVKPSELSKEVGISKAEALETLQIIRRECLTNKpryagtseshkkCTALELLEQEHTQGFIITFCS 105
Cdd:PTZ00035 38 KLKEAGICTVESVAYATKKDLCNIKGISEAKVEKIKEAASKLVPMGF------------ISATEYLEARKNIIRITTGST 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 106 ALDDILGGGVPLMKTTEICGAPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFMVDRVVDlataciqhlqlIAE 185
Cdd:PTZ00035 106 QLDKLLGGGIETGSITELFGEFRTGKTQLCHTLCVTCQLPIEQGGGEGKVLYIDTEGTFRPERIVQ-----------IAE 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 186 KHK--GEEhrkaledfTLDNILshiyYFRCrdYT-----ELLAQVyllPDFLSEhSKVRLVIVDGIAFPFRHDLD---DL 255
Cdd:PTZ00035 175 RFGldPED--------VLDNIA----YARA--YNhehqmQLLSQA---AAKMAE-ERFALLIVDSATALFRVDYSgrgEL 236
|
250 260 270
....*....|....*....|....*....|....*.
gi 578831209 256 SLRTRLLNGLAQQMISLANNHRLAVILTNQMTTKID 291
Cdd:PTZ00035 237 AERQQHLGKFLRALQKLADEFNVAVVITNQVMADVD 272
|
|
| Rad51_DMC1_archRadA |
cd01123 |
recombinase Rad51, DMC1, and archaeal RadA; This group of recombinases includes the eukaryotic ... |
100-291 |
5.77e-27 |
|
recombinase Rad51, DMC1, and archaeal RadA; This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal protein RadA. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a similar recombination reaction as RecA, using ATP-dependent DNA binding activity and a DNA-dependent ATPase. However, this reaction is less efficient and requires accessory proteins such as RAD55/57 .
Pssm-ID: 410868 [Multi-domain] Cd Length: 234 Bit Score: 106.46 E-value: 5.77e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 100 IITFCSALDDILGGGVPLMKTTEICGAPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFMVDRVVDLAtaciqh 179
Cdd:cd01123 1 ITTGSKELDKLLGGGIETGSITEMFGEFRTGKTQLCHTLAVTCQLPIDRGGGEGKAIYIDTEGTFRPERLRAIA------ 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 180 lqliaeKHKGEEHrkaledftlDNILSHIYYFRCRDYTELLAQVYLLPDFLSEhSKVRLVIVDGIAFPFRHDLD---DLS 256
Cdd:cd01123 75 ------QRFGLDP---------DDVLDNVAYARAFNSDHQTQLLDQAAAMMVE-SRFKLLIVDSATALYRTDYSgrgELS 138
|
170 180 190
....*....|....*....|....*....|....*
gi 578831209 257 LRTRLLNGLAQQMISLANNHRLAVILTNQMTTKID 291
Cdd:cd01123 139 ARQMHLAKFLRMLQRLADEFGVAVVVTNQVVAQVD 173
|
|
| recomb_DMC1 |
TIGR02238 |
meiotic recombinase Dmc1; This model describes DMC1, a subfamily of a larger family of DNA ... |
26-288 |
1.50e-26 |
|
meiotic recombinase Dmc1; This model describes DMC1, a subfamily of a larger family of DNA repair and recombination proteins. It is eukaryotic only and most closely related to eukaryotic RAD51. It also resembles archaeal RadA (TIGR02236) and RadB (TIGR02237) and bacterial RecA (TIGR02012). It has been characterized for human as a recombinase active only in meiosis.
Pssm-ID: 131292 [Multi-domain] Cd Length: 313 Bit Score: 107.17 E-value: 1.50e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 26 KLVSAGFQTAEELLEVKPSELSKEVGISKAEALETLQIIRRECltnKPRYAgtseshkkcTALELLEQEHTQGFIITFCS 105
Cdd:TIGR02238 16 KLKSAGICTVNGVIMTTRRALCKIKGLSEAKVDKIKEAASKII---NPGFI---------TAFEISQKRKKVLKITTGSQ 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 106 ALDDILGGGVPLMKTTEICGAPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFMVDRVVDlataciqhlqlIAE 185
Cdd:TIGR02238 84 ALDGILGGGIESMSITEVFGEFRCGKTQLSHTLCVTAQLPREMGGGNGKVAYIDTEGTFRPDRIRA-----------IAE 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 186 KHkGEEHrkaleDFTLDNILshiyYFRCRDYTELLAQVYLLPDFLSEhSKVRLVIVDGIAFPFRHDLD---DLSLRTRLL 262
Cdd:TIGR02238 153 RF-GVDP-----DAVLDNIL----YARAYTSEHQMELLDYLAAKFSE-EPFRLLIVDSIMALFRVDFSgrgELSERQQKL 221
|
250 260
....*....|....*....|....*.
gi 578831209 263 NGLAQQMISLANNHRLAVILTNQMTT 288
Cdd:TIGR02238 222 AQMLSRLNKISEEFNVAVFVTNQVQA 247
|
|
| radB |
PRK09361 |
DNA repair and recombination protein RadB; Provisional |
100-291 |
2.83e-26 |
|
DNA repair and recombination protein RadB; Provisional
Pssm-ID: 236482 [Multi-domain] Cd Length: 225 Bit Score: 104.17 E-value: 2.83e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 100 IITFCSALDDILGGGVPLMKTTEICGAPGVGKTQLCMQLAVDVQIPEcfggvaGEAVFIDTEGsFMVDRVVDLATaciqh 179
Cdd:PRK09361 5 LPTGCKMLDELLGGGFERGTITQIYGPPGSGKTNICLQLAVEAAKNG------KKVIYIDTEG-LSPERFKQIAG----- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 180 lqliaekhkgeehrkalEDFtlDNILSHIYYFRCRDYTELLAQVYLLPDFLSEhsKVRLVIVDGIAFPFRHDLDDLSLRT 259
Cdd:PRK09361 73 -----------------EDF--EELLSNIIIFEPSSFEEQSEAIRKAEKLAKE--NVGLIVLDSATSLYRLELEDEEDNS 131
|
170 180 190
....*....|....*....|....*....|....*
gi 578831209 260 RLLNGLAQQM---ISLANNHRLAVILTNQMTTKID 291
Cdd:PRK09361 132 KLNRELGRQLthlLKLARKHDLAVVITNQVYSDID 166
|
|
| PLN03187 |
PLN03187 |
meiotic recombination protein DMC1 homolog; Provisional |
8-285 |
3.77e-26 |
|
meiotic recombination protein DMC1 homolog; Provisional
Pssm-ID: 215620 [Multi-domain] Cd Length: 344 Bit Score: 106.40 E-value: 3.77e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 8 FEMQRDLVSFPLSPAVRVKLVSAGFQTAEELLEVKPSELSKEVGISKAEALETLQIIRRecLTNKpryagtseshKKCTA 87
Cdd:PLN03187 28 FESIDKLISQGINAGDVKKLQDAGIYTCNGLMMHTKKNLTGIKGLSEAKVDKICEAAEK--LLNQ----------GFITG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 88 LELLEQEHTQGFIITFCSALDDILGGGVPLMKTTEICGAPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFMVD 167
Cdd:PLN03187 96 SDALLKRKSVVRITTGSQALDELLGGGIETRCITEAFGEFRSGKTQLAHTLCVTTQLPTEMGGGNGKVAYIDTEGTFRPD 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 168 RVVDLAtaciqhlqliaekhkgeehrkalEDFTLDN--ILSHIYYFRCRDYTELLAQVYLLPDFLSEHSkVRLVIVDGIA 245
Cdd:PLN03187 176 RIVPIA-----------------------ERFGMDAdaVLDNIIYARAYTYEHQYNLLLGLAAKMAEEP-FRLLIVDSVI 231
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 578831209 246 FPFRHDL---DDLSLRTRLLNGLAQQMISLANNHRLAVILTNQ 285
Cdd:PLN03187 232 ALFRVDFtgrGELAERQQKLAQMLSRLTKIAEEFNVAVYMTNQ 274
|
|
| archRadB |
cd01394 |
archaeal RadB; The archaeal protein RadB shares similarity RadA, the archaeal functional ... |
100-298 |
2.97e-25 |
|
archaeal RadB; The archaeal protein RadB shares similarity RadA, the archaeal functional homologue to the bacterial RecA. The precise function of RadB is unclear.
Pssm-ID: 410882 [Multi-domain] Cd Length: 216 Bit Score: 101.24 E-value: 2.97e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 100 IITFCSALDDILGGGVPLMKTTEICGAPGVGKTQLCMQLAVDVqipecfGGVAGEAVFIDTEGsFMVDRVVDLAtaciqh 179
Cdd:cd01394 1 LSTGSKSLDSLLGGGVERGTITQIYGPPGSGKTNICLQLAVEA------AKQGKKVVYIDTEG-LSPERFQQIA------ 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 180 lqliaekhkGEEHRKaledftldnILSHIYYFRCRDYTELLAQVYLLPDFLSEHsKVRLVIVDGIAFPFRHDLDDLSlrt 259
Cdd:cd01394 68 ---------GERFES---------IASNIIVFEPYSFDEQGVAIQEAEKLLKSD-KVDLVVVDSATALYRLELGDDS--- 125
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 578831209 260 RLLNGLAQQMI---SLANNHRLAVILTNQMTTKIDRNQALLV 298
Cdd:cd01394 126 EANRELSRQMSkllSIARKYDIPVVITNQVYSDIDDDRLKPV 167
|
|
| PLN03186 |
PLN03186 |
DNA repair protein RAD51 homolog; Provisional |
26-291 |
8.48e-25 |
|
DNA repair protein RAD51 homolog; Provisional
Pssm-ID: 178728 [Multi-domain] Cd Length: 342 Bit Score: 102.89 E-value: 8.48e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 26 KLVSAGFQTAEELLEVKPSELSKEVGISKAEALETLQiirrecLTNKPRYAGTseshkkCTALELLEQEHTQGFIITFCS 105
Cdd:PLN03186 43 KLKDAGIHTVESLAYAPKKDLLQIKGISEAKVEKILE------AASKLVPLGF------TTASQLHAQRQEIIQITTGSR 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 106 ALDDILGGGVPLMKTTEICGAPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFMVDRVVDlataciqhlqlIAE 185
Cdd:PLN03186 111 ELDKILEGGIETGSITEIYGEFRTGKTQLCHTLCVTCQLPLDQGGGEGKAMYIDTEGTFRPQRLIQ-----------IAE 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 186 KhkgeehrkaledFTLD--NILSHIYYFRCRDyTELLAQVYLLPDFLSEHSKVRLVIVDGIAFPFRHDLD---DLSLRTR 260
Cdd:PLN03186 180 R------------FGLNgaDVLENVAYARAYN-TDHQSELLLEAASMMAETRFALMIVDSATALYRTEFSgrgELSARQM 246
|
250 260 270
....*....|....*....|....*....|.
gi 578831209 261 LLNGLAQQMISLANNHRLAVILTNQMTTKID 291
Cdd:PLN03186 247 HLGKFLRSLQRLADEFGVAVVITNQVVAQVD 277
|
|
| XRCC2 |
cd19490 |
XRCC2 recombinase; XRCC2 (X-ray repair complementing defective repair in Chinese hamster cells ... |
122-314 |
1.73e-24 |
|
XRCC2 recombinase; XRCC2 (X-ray repair complementing defective repair in Chinese hamster cells 2) recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. XRCC2, together with the other RAD51 paralogs, RAD51B, RAD51C, RAD51D, and XRCC3, helps recruit RAD51 to the break site.
Pssm-ID: 410898 [Multi-domain] Cd Length: 226 Bit Score: 99.34 E-value: 1.73e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 122 EICGAPGVGKTQLCMQLAVDVQIPECFGGVA-----GEAVFIDTEGSFMVDRVVDLATACIQHLQLIAEKHKGEEHRkal 196
Cdd:cd19490 5 EITGPSGSGKTELLYHLAARCILPSSWGGVPlggleAAVVFIDTDGRFDILRLRSILEARIRAAIQAANSSDDEEDV--- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 197 eDFTLDNILSHIYYFRCRDYTELLAQVYLLPDFL---SEHSKVRLVIVDGIAFPFRHD-------LDDLSLRTRLLNGLA 266
Cdd:cd19490 82 -EEIARECLQRLHIFRCHSSLQLLATLLSLENYLlslSANPELGLLLIDSISAFYWQDrfsaelaRAAPLLQEAALRAIL 160
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 578831209 267 QQMISLANNHRLAVILTNQMTTKIDRNQALLVPALGWQHCTSHPARRN 314
Cdd:cd19490 161 RELRRLRRRFQLVVIATKQALFPGKSASTDNPAANNAVSKASAPSHRE 208
|
|
| recomb_RAD51 |
TIGR02239 |
DNA repair protein RAD51; This eukaryotic sequence family consists of RAD51, a protein ... |
26-299 |
2.09e-22 |
|
DNA repair protein RAD51; This eukaryotic sequence family consists of RAD51, a protein involved in DNA homologous recombination and repair. It is similar in sequence the exclusively meiotic recombinase DMC1 (TIGR02238), to archaeal families RadA (TIGR02236) and RadB (TIGR02237), and to bacterial RecA (TIGR02012).
Pssm-ID: 274048 [Multi-domain] Cd Length: 316 Bit Score: 95.56 E-value: 2.09e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 26 KLVSAGFQTAEELLEVKPSELSKEVGISKAEALETLqiirrecltnkpryagtSESHKK-----CTALELLEQEHTQGFI 100
Cdd:TIGR02239 16 KLQEAGLHTVESVAYAPKKQLLEIKGISEAKADKIL-----------------AEAAKLvpmgfTTATEFHQRRQEVIQL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 101 ITFCSALDDILGGGVPLMKTTEICGAPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFMVDRVVDlataciqhl 180
Cdd:TIGR02239 79 TTGSKELDKLLGGGIETGSITEIFGEFRTGKTQLCHTLAVTCQLPIDQGGGEGKALYIDTEGTFRPERLLA--------- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 181 qlIAEKHK--GEEhrkaledfTLDNIlSHIYYFRCRDYTELLAQVYLLpdfLSEhSKVRLVIVDGIAFPFRHDLD---DL 255
Cdd:TIGR02239 150 --IAERYGlnPED--------VLDNV-AYARAYNTDHQLQLLQQAAAM---MSE-SRFALLIVDSATALYRTDFSgrgEL 214
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 578831209 256 SLRTRLLNGLAQQMISLANNHRLAVILTNQMTTKIDRNQALLVP 299
Cdd:TIGR02239 215 SARQMHLARFLRSLQRLADEFGVAVVITNQVVAQVDGAGSMFAG 258
|
|
| Rad51 |
cd19513 |
RAD51D recombinase; RAD51 recombinase plays an essential role in DNA repair by homologous ... |
100-291 |
4.20e-22 |
|
RAD51D recombinase; RAD51 recombinase plays an essential role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51 is recruited to the break site with the help of its paralogs, RAD51D, RAD51B, RAD51C, XRCC3, and XRCC2, where it forms long helical polymers which wrap around the ssDNA tail at the break which leads to pairing and strand invasion.
Pssm-ID: 410921 [Multi-domain] Cd Length: 235 Bit Score: 93.15 E-value: 4.20e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 100 IITFCSALDDILGGGVPLMKTTEICGAPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFMVDRvvdlataciqh 179
Cdd:cd19513 1 ITTGSKELDKLLGGGIETGSITELFGEFRTGKTQLCHTLAVTCQLPIDQGGGEGKALYIDTEGTFRPER----------- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 180 LQLIAEKHK--GEEhrkaledfTLDNIlSHIYYFRCRDYTELLAQVYLLpdfLSEhSKVRLVIVDGIAFPFRHDLD---D 254
Cdd:cd19513 70 LLAIAERYGlnGED--------VLDNV-AYARAYNTDHQMQLLIQASAM---MAE-SRYALLIVDSATALYRTDYSgrgE 136
|
170 180 190
....*....|....*....|....*....|....*..
gi 578831209 255 LSLRTRLLNGLAQQMISLANNHRLAVILTNQMTTKID 291
Cdd:cd19513 137 LSARQMHLAKFLRMLQRLADEFGVAVVITNQVVAQVD 173
|
|
| Rad51D |
cd19489 |
RAD51D recombinase; RAD51D recombinase, a RAD51 paralog, plays an important role in DNA repair ... |
112-302 |
3.46e-20 |
|
RAD51D recombinase; RAD51D recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51D, together with the other RAD51 paralogs, RAD51B, RAD51C, XRCC3, and XRCC2, helps recruit RAD51 to the break site.
Pssm-ID: 410897 [Multi-domain] Cd Length: 209 Bit Score: 87.31 E-value: 3.46e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 112 GGGVPLMKTTEICGAPGVGKTQLCMQLAVDVQipeCFGGVAgeAVFIDTEGSFMVDRVVDLATACIQHLQLIAEkhkgee 191
Cdd:cd19489 1 GGGLRTGEITELVGESSSGKTQLCLTAAANVA---SRSGQN--VLYIDTKSSFSARRLAQILKSRAQDAEEIDK------ 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 192 hrkaledftldnILSHIYYFRCRDYTELLAQVYLLPDFLS-----EHSKVRLVIVDGIAFPFRHDLDDLSLR--TRLLNG 264
Cdd:cd19489 70 ------------ALQRIRVVRVFDPYELLDLLEELRNTLSqqqenLYSRLKLVIIDSLSALISPLLGGSKHSegHALLAS 137
|
170 180 190
....*....|....*....|....*....|....*....
gi 578831209 265 LAQQMISLANNHRLAVILTNQMTTKID-RNQALLVPALG 302
Cdd:cd19489 138 LARLLKKLAAEYQIAVLVTNLTVRGGDgGQQGSTKPALG 176
|
|
| recomb_radB |
TIGR02237 |
DNA repair and recombination protein RadB; This family consists exclusively of archaeal RadB ... |
107-291 |
4.52e-16 |
|
DNA repair and recombination protein RadB; This family consists exclusively of archaeal RadB protein, a homolog of bacterial RecA (TIGR02012), eukaryotic RAD51 (TIGR02239) and DMC1 (TIGR02238), and archaeal RadA (TIGR02236).
Pssm-ID: 274047 [Multi-domain] Cd Length: 209 Bit Score: 75.92 E-value: 4.52e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 107 LDDILGGGVPLMKTTEICGAPGVGKTQLCMQLAVDVQipecfgGVAGEAVFIDTEGsFMVDRVVDLATAciqhlqliaek 186
Cdd:TIGR02237 1 IDELLGGGVERGTITQIYGPPGSGKTNICMILAVNAA------RQGKKVVYIDTEG-LSPERFKQIAED----------- 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 187 hkgeehrkaledfTLDNILSHIYYFRCRDYTELLAQVYLLPDFLSEHsKVRLVIVDGIAFPFRHDL-DDLSLRTRLLNGL 265
Cdd:TIGR02237 63 -------------RPERALSNFIVFEVFDFDEQGVAIQKTSKFIDRD-SASLVVVDSFTALYRLELsDDRISRNRELARQ 128
|
170 180
....*....|....*....|....*.
gi 578831209 266 AQQMISLANNHRLAVILTNQMTTKID 291
Cdd:TIGR02237 129 LTLLLSLARKKNLAVVITNQVYTDVN 154
|
|
| RAD55 |
COG0467 |
RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms]; |
107-288 |
1.62e-08 |
|
RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];
Pssm-ID: 440235 [Multi-domain] Cd Length: 221 Bit Score: 54.15 E-value: 1.62e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 107 LDDILGGGVPLMKTTEICGAPGVGKTQLCMQLAVDvqipecfGGVAGE-AVFIDTEGSfmVDRVVDLAtaciqhlqliae 185
Cdd:COG0467 9 LDELLGGGLPRGSSTLLSGPPGTGKTTLALQFLAE-------GLRRGEkGLYVSFEES--PEQLLRRA------------ 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 186 KHKGEEHRKALEDFTLdNILSHIYYFRCRDYTELLAQvylLPDFLSEHsKVRLVIVDGIAfPFRHDLDDLSLRTRLLNGL 265
Cdd:COG0467 68 ESLGLDLEEYIESGLL-RIIDLSPEELGLDLEELLAR---LREAVEEF-GAKRVVIDSLS-GLLLALPDPERLREFLHRL 141
|
170 180
....*....|....*....|...
gi 578831209 266 aqqmISLANNHRLAVILTNQMTT 288
Cdd:COG0467 142 ----LRYLKKRGVTTLLTSETGG 160
|
|
| RecA |
COG0468 |
RecA/RadA recombinase [Replication, recombination and repair]; |
100-164 |
1.45e-07 |
|
RecA/RadA recombinase [Replication, recombination and repair];
Pssm-ID: 440236 [Multi-domain] Cd Length: 351 Bit Score: 52.48 E-value: 1.45e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578831209 100 IITFCSALDDILG-GGVPLMKTTEICGAPGVGKTQLCMQLAVDVQIPecfGGVageAVFIDTEGSF 164
Cdd:COG0468 44 ISTGSLALDIALGvGGLPRGRIVEIYGPESSGKTTLALHAIAEAQKA---GGI---AAFIDAEHAL 103
|
|
| AAA_25 |
pfam13481 |
AAA domain; This AAA domain is found in a wide variety of presumed DNA repair proteins. |
98-283 |
6.31e-07 |
|
AAA domain; This AAA domain is found in a wide variety of presumed DNA repair proteins.
Pssm-ID: 463892 [Multi-domain] Cd Length: 193 Bit Score: 49.30 E-value: 6.31e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 98 GFIITFCSALDDILGGGVPLMKTTEICGAPGVGKTQLCMQLAVDV--QIPECFGGVAGEA---VFIDTEGSF--MVDRVv 170
Cdd:pfam13481 13 DGLAAPPPPRRWLIKGLLPAGGLGLLAGAPGTGKTTLALDLAAAVatGKPWLGGPRVPEQgkvLYVSAEGPAdeLRRRL- 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 171 dlataciqhlqliaekhkgeehRKALEDFTLDNILSHIYYFRCRDYTELLAQVYLLPDFLS-------EHSKVRLVIVDG 243
Cdd:pfam13481 92 ----------------------RAAGADLDLPARLLFLSLVESLPLFFLDRGGPLLDADVDaleaaleEVEDPDLVVIDP 149
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 578831209 244 IAFPFRHDLDDLSLRTRLLNGLAQqmisLANNHRLAVILT 283
Cdd:pfam13481 150 LARALGGDENSNSDVGRLVKALDR----LARRTGATVLLV 185
|
|
| PRK09302 |
PRK09302 |
circadian clock protein KaiC; Reviewed |
107-137 |
4.16e-05 |
|
circadian clock protein KaiC; Reviewed
Pssm-ID: 236461 [Multi-domain] Cd Length: 509 Bit Score: 45.26 E-value: 4.16e-05
10 20 30
....*....|....*....|....*....|.
gi 578831209 107 LDDILGGGVPLMKTTEICGAPGVGKTQLCMQ 137
Cdd:PRK09302 20 FDDITHGGLPKGRPTLVSGTAGTGKTLFALQ 50
|
|
| ATPase |
pfam06745 |
KaiC; This family is in the P-loop NTPase superfamily and is found in archaea, bacteria and ... |
107-140 |
4.48e-05 |
|
KaiC; This family is in the P-loop NTPase superfamily and is found in archaea, bacteria and eukaryotes. More than one copy is sometimes found in each protein. This family includes KaiC, which is one of the Kai proteins among which direct protein-protein association may be a critical process in the generation of circadian rhythms in cyanobacteria.
Pssm-ID: 429095 [Multi-domain] Cd Length: 231 Bit Score: 44.16 E-value: 4.48e-05
10 20 30
....*....|....*....|....*....|....
gi 578831209 107 LDDILGGGVPLMKTTEICGAPGVGKTQLCMQLAV 140
Cdd:pfam06745 8 LDEILKGGFPEGRVVLITGGPGTGKTIFGLQFLY 41
|
|
| KaiC-like |
cd01124 |
Circadian Clock Protein KaiC; KaiC is a circadian clock protein, most studied in cyanobacteria. ... |
107-140 |
1.59e-04 |
|
Circadian Clock Protein KaiC; KaiC is a circadian clock protein, most studied in cyanobacteria. KaiC, an autokinase, autophosphatase, and ATPase, is part of the core oscillator, composed of three proteins: KaiA, KaiB, and KaiC. The circadian oscillation is regulated via KaiC phosphorylation.
Pssm-ID: 410869 [Multi-domain] Cd Length: 222 Bit Score: 42.25 E-value: 1.59e-04
10 20 30
....*....|....*....|....*....|....
gi 578831209 107 LDDILGGGVPLMKTTEICGAPGVGKTQLCMQLAV 140
Cdd:cd01124 8 LDELLGGGIPKGSVTLLTGGPGTGKTLFGLQFLY 41
|
|
| KaiC-N |
cd19485 |
N-terminal domain of Circadian Clock Protein Kaic; KaiC is a circadian clock protein, most ... |
107-137 |
2.47e-04 |
|
N-terminal domain of Circadian Clock Protein Kaic; KaiC is a circadian clock protein, most studied in cyanobacteria. KaiC, an autokinase, autophosphatase, and ATPase, is part of the core oscillator, composed of three proteins: KaiA, KaiB, and KaiC. The circadian oscillation is regulated via KaiC phosphorylation.
Pssm-ID: 410893 [Multi-domain] Cd Length: 226 Bit Score: 41.97 E-value: 2.47e-04
10 20 30
....*....|....*....|....*....|.
gi 578831209 107 LDDILGGGVPLMKTTEICGAPGVGKTQLCMQ 137
Cdd:cd19485 8 FDDITHGGLPKGRPTLICGTAGTGKTLFAAQ 38
|
|
| RecA |
cd00983 |
recombinase A; RecA is a bacterial enzyme which has roles in homologous recombination, DNA ... |
99-164 |
5.23e-04 |
|
recombinase A; RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange.
Pssm-ID: 410863 [Multi-domain] Cd Length: 235 Bit Score: 41.00 E-value: 5.23e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 578831209 99 FIITFCSALDDILG-GGVPLMKTTEICGAPGVGKTQLCMQLAVDVQIpecFGGVageAVFIDTEGSF 164
Cdd:cd00983 4 VIPTGSLSLDIALGiGGLPRGRIIEIYGPESSGKTTLALHAIAEAQK---LGGT---AAFIDAEHAL 64
|
|
| RepA |
COG3598 |
RecA-family ATPase [Replication, recombination and repair]; |
115-282 |
1.38e-03 |
|
RecA-family ATPase [Replication, recombination and repair];
Pssm-ID: 442817 [Multi-domain] Cd Length: 313 Bit Score: 39.88 E-value: 1.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 115 VPLMKTTEICGAPGVGKTQLCMQLAVDVQIPECFGGV---AGEAVFIDTEGSF--MVDRVVDLATACiqhlqliaekhkg 189
Cdd:COG3598 10 LPEGGVTLLAGPPGTGKSFLALQLAAAVAAGGPWLGRrvpPGKVLYLAAEDDRgeLRRRLKALGADL------------- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578831209 190 eehrkaleDFTLDNILSHIYYFRCRDYTELLAQVYLLPDFLsEHSKVRLVIVDGIAFPFRHDLDDLSLRTRLLNGLAQqm 269
Cdd:COG3598 77 --------GLPFADLDGRLRLLSLAGDLDDTDDLEALERAI-EEEGPDLVVIDPLARVFGGDENDAEEMRAFLNPLDR-- 145
|
170
....*....|...
gi 578831209 270 isLANNHRLAVIL 282
Cdd:COG3598 146 --LAERTGAAVLL 156
|
|
| KaiC-like_C |
cd19487 |
C-terminal domain of KaiC family protein; uncharacterized subfamily; KaiC is a circadian clock ... |
105-140 |
9.37e-03 |
|
C-terminal domain of KaiC family protein; uncharacterized subfamily; KaiC is a circadian clock protein, most studied in cyanobacteria. KaiC, an autokinase, autophosphatase, and ATPase, is part of the core oscillator, composed of three proteins: KaiA, KaiB, and KaiC. The circadian oscillation is regulated via KaiC phosphorylation.
Pssm-ID: 410895 [Multi-domain] Cd Length: 219 Bit Score: 36.89 E-value: 9.37e-03
10 20 30
....*....|....*....|....*....|....*.
gi 578831209 105 SALDDILGGGVPLMKTTEICGAPGVGKTQLCMQLAV 140
Cdd:cd19487 6 PELDELLGGGLERGTSTLLIGPAGVGKSTLALQFAK 41
|
|
| |
