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Conserved domains on  [gi|578833565|ref|XP_006722936|]
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zinc finger protein 69 isoform X1 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 26-67 3.44e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 89.45  E-value: 3.44e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 578833565   26 PVAFDDVAVNFTQEEWALLDISQRKLYKEVMLETFRNLTSVG 67
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
222-540 4.32e-12

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.57  E-value: 4.32e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578833565 222 PYKCKFCGKAFHCLSLYLIHERIHTGEKPYEC--KQCGKSFSYSATLRIHERTHTGEKPYECQQCGKAFHSPRCYRRHER 299
Cdd:COG5048   33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSS 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578833565 300 IHTGE-KAYQCKECGKAFTCPQYVRIHERTHSRKKPYECTQC-GKALSSLTSFQTHIRMHSgerpyecKICGKGFCSANS 377
Cdd:COG5048  113 SSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPA-------NSLSKDPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578833565 378 FQRHEKTHSGEKPYKCKQCGKAFIHSSSLRYHERIHTGEKPYECKQCGKAFRSSSHLQLHGRTHTGEKPYECQECGKAFR 457
Cdd:COG5048  186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578833565 458 SMKNLQSHERTQTHVRIHSGER-PYKCKLCGKGFYCPKSLQRHEKT--HTGEKLYECKQ----CGEAFSSSSSFRYHERT 530
Cdd:COG5048  266 PTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRSvnHSGESLKPFSCpyslCGKLFSRNDALKRHILL 345

                        330
                 ....*....|
gi 578833565 531 HTGEKPYKCK 540
Cdd:COG5048  346 HTSISPAKEK 355
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 26-67 3.44e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 89.45  E-value: 3.44e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 578833565   26 PVAFDDVAVNFTQEEWALLDISQRKLYKEVMLETFRNLTSVG 67
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
27-67 9.89e-20

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 83.03  E-value: 9.89e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 578833565    27 VAFDDVAVNFTQEEWALLDISQRKLYKEVMLETFRNLTSVG 67
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 27-65 3.69e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 74.89  E-value: 3.69e-17
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 578833565  27 VAFDDVAVNFTQEEWALLDISQRKLYKEVMLETFRNLTS 65
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
222-540 4.32e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.57  E-value: 4.32e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578833565 222 PYKCKFCGKAFHCLSLYLIHERIHTGEKPYEC--KQCGKSFSYSATLRIHERTHTGEKPYECQQCGKAFHSPRCYRRHER 299
Cdd:COG5048   33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSS 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578833565 300 IHTGE-KAYQCKECGKAFTCPQYVRIHERTHSRKKPYECTQC-GKALSSLTSFQTHIRMHSgerpyecKICGKGFCSANS 377
Cdd:COG5048  113 SSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPA-------NSLSKDPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578833565 378 FQRHEKTHSGEKPYKCKQCGKAFIHSSSLRYHERIHTGEKPYECKQCGKAFRSSSHLQLHGRTHTGEKPYECQECGKAFR 457
Cdd:COG5048  186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578833565 458 SMKNLQSHERTQTHVRIHSGER-PYKCKLCGKGFYCPKSLQRHEKT--HTGEKLYECKQ----CGEAFSSSSSFRYHERT 530
Cdd:COG5048  266 PTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRSvnHSGESLKPFSCpyslCGKLFSRNDALKRHILL 345

                        330
                 ....*....|
gi 578833565 531 HTGEKPYKCK 540
Cdd:COG5048  346 HTSISPAKEK 355
zf-H2C2_2 pfam13465
Zinc-finger double domain;
405-430 3.10e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.10e-04
                          10        20
                  ....*....|....*....|....*.
gi 578833565  405 SLRYHERIHTGEKPYECKQCGKAFRS 430
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 26-67 3.44e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 89.45  E-value: 3.44e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 578833565   26 PVAFDDVAVNFTQEEWALLDISQRKLYKEVMLETFRNLTSVG 67
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
27-67 9.89e-20

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 83.03  E-value: 9.89e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 578833565    27 VAFDDVAVNFTQEEWALLDISQRKLYKEVMLETFRNLTSVG 67
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 27-65 3.69e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 74.89  E-value: 3.69e-17
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 578833565  27 VAFDDVAVNFTQEEWALLDISQRKLYKEVMLETFRNLTS 65
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
222-540 4.32e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.57  E-value: 4.32e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578833565 222 PYKCKFCGKAFHCLSLYLIHERIHTGEKPYEC--KQCGKSFSYSATLRIHERTHTGEKPYECQQCGKAFHSPRCYRRHER 299
Cdd:COG5048   33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSS 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578833565 300 IHTGE-KAYQCKECGKAFTCPQYVRIHERTHSRKKPYECTQC-GKALSSLTSFQTHIRMHSgerpyecKICGKGFCSANS 377
Cdd:COG5048  113 SSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPA-------NSLSKDPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578833565 378 FQRHEKTHSGEKPYKCKQCGKAFIHSSSLRYHERIHTGEKPYECKQCGKAFRSSSHLQLHGRTHTGEKPYECQECGKAFR 457
Cdd:COG5048  186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578833565 458 SMKNLQSHERTQTHVRIHSGER-PYKCKLCGKGFYCPKSLQRHEKT--HTGEKLYECKQ----CGEAFSSSSSFRYHERT 530
Cdd:COG5048  266 PTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRSvnHSGESLKPFSCpyslCGKLFSRNDALKRHILL 345

                        330
                 ....*....|
gi 578833565 531 HTGEKPYKCK 540
Cdd:COG5048  346 HTSISPAKEK 355
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
187-528 2.25e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.55  E-value: 2.25e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578833565 187 RDHTGEKPYAC--KECGKTFISHSSIQRHVVMHSGDGPYKC-KFCGKAFHCLSLYLIHERIHTGEKPYECKQCGKSFSYS 263
Cdd:COG5048   54 RSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSR 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578833565 264 ATLRIHERTHTGEKPYECQQCGKAF----------------------HSPRCYRRHERIHTGEKAYQCKECGKAFTCPQY 321
Cdd:COG5048  134 DPQLPDLLSISNLRNNPLPGNNSSSvntpqsnslhpplpanslskdpSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPS 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578833565 322 VRIHERTHSRKKPYECTQCG-------KALSSLTSFQTHIRMHSGERPYECKIcGKGFCSANSFQRHEKTHSG-EKPYKC 393
Cdd:COG5048  214 SSSDQNLENSSSSLPLTTNSqlspkslLSQSPSSLSSSDSSSSASESPRSSLP-TASSQSSSPNESDSSSEKGfSLPIKS 292

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578833565 394 KQCGKAFIHSSSLRYHER--IHTGE--KPYEC--KQCGKAFRSSSHLQLHGRTHTGEKPYEC--QECGKAFRSMKNLQSH 465
Cdd:COG5048  293 KQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPP 372

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578833565 466 ERTQTHVRIH-------------------------------SGERPYKCKLCGKGFYCPKSLQRHEKTHTGEKLYECKQC 514
Cdd:COG5048  373 QSLQQYKDLKndkksetlsnscirnfkrdsnlslhiithlsFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSIL 452

                        410
                 ....*....|....
gi 578833565 515 GEAFSSSSSFRYHE 528
Cdd:COG5048  453 KSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
405-430 3.10e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.10e-04
                          10        20
                  ....*....|....*....|....*.
gi 578833565  405 SLRYHERIHTGEKPYECKQCGKAFRS 430
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 387-471 4.39e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.78  E-value: 4.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578833565 387 GEKPYKCK--QCGKAFIHSSSLRYHeRIHtgekpyecKQCGKAFRSSSHLQLHGRTHTGEKPYECQECGKAFRSMKNLQS 464
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*..
gi 578833565 465 HeRTQTH 471
Cdd:COG5189  417 H-RKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
377-402 6.53e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.53e-04
                          10        20
                  ....*....|....*....|....*.
gi 578833565  377 SFQRHEKTHSGEKPYKCKQCGKAFIH 402
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
523-546 9.67e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 9.67e-04
                          10        20
                  ....*....|....*....|....
gi 578833565  523 SFRYHERTHTGEKPYKCKQCGKAF 546
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
294-318 1.34e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.34e-03
                          10        20
                  ....*....|....*....|....*
gi 578833565  294 YRRHERIHTGEKAYQCKECGKAFTC 318
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
266-288 1.50e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.50e-03
                          10        20
                  ....*....|....*....|...
gi 578833565  266 LRIHERTHTGEKPYECQQCGKAF 288
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
417-471 1.83e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.83  E-value: 1.83e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 578833565 417 KPYECKQCGKAFRSSSHLQLHGRTHTGEKPYECQECGKAFRSMKNLQSHERTQTH 471
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTH 86
zf-H2C2_2 pfam13465
Zinc-finger double domain;
241-262 2.00e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.00e-03
                          10        20
                  ....*....|....*....|..
gi 578833565  241 HERIHTGEKPYECKQCGKSFSY 262
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
495-520 3.50e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.50e-03
                          10        20
                  ....*....|....*....|....*.
gi 578833565  495 SLQRHEKTHTGEKLYECKQCGEAFSS 520
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
433-458 5.83e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.83e-03
                          10        20
                  ....*....|....*....|....*.
gi 578833565  433 HLQLHGRTHTGEKPYECQECGKAFRS 458
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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