|
Name |
Accession |
Description |
Interval |
E-value |
| Eukaryotic_PFK |
cd00764 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
79-846 |
0e+00 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.
Pssm-ID: 238389 [Multi-domain] Cd Length: 762 Bit Score: 1415.35 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 79 GMNAAVRAVTRMGIYVGAKVFLIYEeqrmpyclspsprgrfgarppswGYEGLVEGGENIKQANWLSVSNIIQLGGTIIG 158
Cdd:cd00764 17 GMNAAVRAVVRMGIYVGAKVFFVYE-----------------------GYEGLVKGGDYIKQAEWESVSNWLQEGGTIIG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 159 SARCKAFTTREGRRAAAYNLVQHGITNLCVIGGDGSLTGANIFRSEWGSLLEELVAEGKISETTARTYSHLNIAGLVGSI 238
Cdd:cd00764 74 SARCKEFREREGRLQAAYNLIQRGITNLCVIGGDGSLTGADLFRSEWPSLLEELVKDGKITEEEVAKYQHLNIVGMVGSI 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 239 DNDFCGTDMTIGTDSALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWENFMCE 318
Cdd:cd00764 154 DNDFCGTDMTIGTDSALHRICEVVDAITTTAQSHQRTFVLEVMGRHCGYLALVSGLATGADWIFIPERPPEDGWEDQMCR 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 319 RLGETRSRGSRLNIIIIAEGAIDRNGKPISSSYVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMALL 398
Cdd:cd00764 234 RLSEHRSRGKRLNIIIVAEGAIDDQLKPITSEDVKDLVVERLGLDTRVTTLGHVQRGGTPSAFDRILASLMGVEAVMALL 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 399 EATPDTPACVVTLSGNQSVRLPLMECVQMTKEVQKAMDDKRFDEATQLRGGSFENNWNIYKLLAHQKPPK--EKSNFSLA 476
Cdd:cd00764 314 EATPDTPACVVSLNGNKAVRLPLMECVQLTKDVQKAMDEKRFDEAAALRGKSFDKNWNLYKLLAIELPQPlpEKTNLNIA 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 477 ILNVGAPAAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRTLPKGQLESIVEN 556
Cdd:cd00764 394 IVNVGAPAAGMNAAVRSAVRYGLAHGHRPYAIYDGFEGLAKGQIVELGWIDVGGWTGRGGSELGTKRTLPKKDLETIAYN 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 557 IRIYGIHALLVVGGFEAYEGVLQLVEARGRYEELCIVMCVIPATISNNVPGTDFSLGSDTAVNAAMESCDRIKQSASGTK 636
Cdd:cd00764 474 FQKYGIDGLIIVGGFEAYKGLLQLREAREQYEEFCIPMVLIPATVSNNVPGTDFSLGSDTALNALMKYCDRIKQSASGTK 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 637 RRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIHDLKVNVEHMTEKMKTDIQRGLVLRNEKCHDYYTTEFLYNLY 716
Cdd:cd00764 554 RRVFIVETMGGYCGYLATMTGLAVGADAAYVFEEPFNIRDLQENVEHLTEKMKTTIGRGLVLRNEKCNENYTTVFTYELY 633
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 717 SSEGKGVFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKAMLWLSEKLREVYRKGRVFANAPDSACVIGLKKKAVAFSPVT 796
Cdd:cd00764 634 SEEGKGVFDCRTNVLGHVQQGGAPSPFDRNFGTKFAVKAMKWIEQKLKENYAAGNEFANDPDFNCVNGVKKYAVLFEPVE 713
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|
gi 578836565 797 ELKKDTdFEHRMPREQWWLSLRLMLKMLAQYRISMAAYVSGELEHVTRRT 846
Cdd:cd00764 714 ELKQTT-FEHRIPKEQWWLSLRPLLKILAKYKISADISDHGQLEHVTRGQ 762
|
|
| 6PF1K_euk |
TIGR02478 |
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ... |
79-828 |
0e+00 |
|
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).
Pssm-ID: 274152 [Multi-domain] Cd Length: 746 Bit Score: 1171.35 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 79 GMNAAVRAVTRMGIYVGAKVFLIYEeqrmpyclspsprgrfgarppswGYEGLVEGGENIKQANWLSVSNIIQLGGTIIG 158
Cdd:TIGR02478 14 GMNAAVRAVVRMAIYVGCRVYAIRE-----------------------GYQGLVDGGDNIEEAQWEDVRGILSLGGTIIG 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 159 SARCKAFTTREGRRAAAYNLVQHGITNLCVIGGDGSLTGANIFRSEWGSLLEELVAEGKISETTARTYSHLNIAGLVGSI 238
Cdd:TIGR02478 71 TARCKEFRERPGRLKAARNLVSNGIDALVVIGGDGSLTGADLFREEWPSLLEELVDTGKITAEQAEEHRHLTIVGLVGSI 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 239 DNDFCGTDMTIGTDSALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWENFMCE 318
Cdd:TIGR02478 151 DNDMCGTDMTIGADSALHRICEAIDAISSTAQSHQRAFVVEVMGRHCGYLALMAAIATGADYVFIPERPPEEGWEDQLCH 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 319 RLGETRSRGSRLNIIIIAEGAIDRNGKPISSSYVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMALL 398
Cdd:TIGR02478 231 KLKRNRKAGKRKTIVIVAEGAIDRDLNPITSEDVKDVLVERLGLDTRITVLGHVQRGGAPSAFDRILATRQGVEAVLAVL 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 399 EATPDTPACVVTLSGNQSVRLPLMECVQMTKEVQKAMDDKRFDEATQLRGGSFENNWNIYKLLAHQKPPK-----EKSNF 473
Cdd:TIGR02478 311 ESTPETPSPVISLRGNKIVRKPLVEAVAQTKTVAKAIEEKDFDEAMRLRGREFAENLETFLFLSIPDDDKklvpsEASRL 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 474 SLAILNVGAPAAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRTLPKGQLESI 553
Cdd:TIGR02478 391 RIAIIHVGAPAGGMNAATRSAVRYALARGHTVIAIHNGFSGLARHDVRELTWSDVEGWVGEGGSELGTNRSLPGDDLGTI 470
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 554 VENIRIYGIHALLVVGGFEAYEGVLQLVEARGRYEELCIVMCVIPATISNNVPGTDFSLGSDTAVNAAMESCDRIKQSAS 633
Cdd:TIGR02478 471 AYYFQQHKIDGLIIIGGFEAFEALYQLDAAREKYPAFRIPMVVIPATISNNVPGTEYSLGSDTALNEITEYCDNIKQSAS 550
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 634 GTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIHDLKVNVEHMTEKMKTDIQRGLVLRNEKCHDYYTTEFLY 713
Cdd:TIGR02478 551 ASKRRVFVVETMGGYSGYLATMAGLATGADAAYIPEEGISLKDLQEDIEHLKETFAEGRAGKLILRNEKASKVYTTDFIA 630
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 714 NLYSSEGKGVFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKAMLWLSEKLREVYRKGRVFANaPDSACVIGLKKKAVAFS 793
Cdd:TIGR02478 631 RIISEEGKGRFDARTAVLGHMQQGGSPSPFDRVRATRLAIRAVDFIEEKIKANKHADKLSAD-DTSAVVIGIRGSNVLFT 709
|
730 740 750
....*....|....*....|....*....|....*.
gi 578836565 794 PV-TELKKDTDFEHRMPREQWWLSLRLMLKMLAQYR 828
Cdd:TIGR02478 710 PVkQLLANETDFEHRRPKNQWWLQLRPLVRILAGRD 745
|
|
| PFK |
cd00363 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
79-456 |
1.18e-173 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.
Pssm-ID: 238216 [Multi-domain] Cd Length: 338 Bit Score: 504.91 E-value: 1.18e-173
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 79 GMNAAVRAVTRMGIYVGAKVFLIYEeqrmpyclspsprgrfgarppswGYEGLVEGgeNIKQANWLSVSNIIQLGGTIIG 158
Cdd:cd00363 14 GMNAAIRGVVRSAIAEGLEVYGIYE-----------------------GYAGLVEG--DIKELDWESVSDIINRGGTIIG 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 159 SARCKAFTTREGRRAAAYNLVQHGITNLCVIGGDGSLTGANIFRSEWGSlleelvaegkisettarTYSHLNIAGLVGSI 238
Cdd:cd00363 69 SARCKEFRTEEGRAKAAENLKKHGIDALVVIGGDGSYTGADLLTEEWPS-----------------KYQGFNVIGLPGTI 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 239 DNDFCGTDMTIGTDSALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWENFMCE 318
Cdd:cd00363 132 DNDIKGTDYTIGFDTALKTIVEAIDRIRDTASSHQRTFVVEVMGRHCGDIALEAGLATGADIIFIPEEPAADEWEEEMVD 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 319 RLGETRSRGSRLNIIIIAEGAIDRNGKPISSSYVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMALL 398
Cdd:cd00363 212 VIKKRRERGKRHGIVIVAEGAIDFIPKPITEKLLAKLVEERLGFDTRATVLGHVQRGGTPTAFDRILASRLGAEAVELLL 291
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 578836565 399 EATPDTPACVVTLSGNQSVRLPLMECVQMTKEVQkamddkrfdeaTQLRGGSFENNWN 456
Cdd:cd00363 292 EGTGGTPVGIQNLNENQVVRHPLTEAVNMTKRVG-----------VDLEGRPFKKFAK 338
|
|
| PFK |
pfam00365 |
Phosphofructokinase; |
78-394 |
2.50e-126 |
|
Phosphofructokinase;
Pssm-ID: 459783 [Multi-domain] Cd Length: 271 Bit Score: 380.15 E-value: 2.50e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 78 GGMNAAVRAVTRMGIYVGAKVFLIYEeqrmpyclspsprgrfgarppswGYEGLVEGgeNIKQANWLSVSNIIQLGGTII 157
Cdd:pfam00365 12 PGMNAAIRAVVRTAIYRGHEVYGIRN-----------------------GYEGLVEG--DIDELTWRDVSGILNRGGTIL 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 158 GSARCKAFTTREGRRAAAYNLVQHGITNLCVIGGDGSLTGANIFRSEWGslleelvaegkisettartyshLNIAGLVGS 237
Cdd:pfam00365 67 GTSRSKPFKTEEGREKIAENLKKLGIDALVVIGGDGSLTGANKLSEERG----------------------IPVVGIPKT 124
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 238 IDNDFCGTDMTIGTDSALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEdgwENFMC 317
Cdd:pfam00365 125 IDNDIPGTDYTIGFDTALNTIVEAIDRIRDTASSHNRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFD---IEELC 201
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 578836565 318 ERLgETRSRGSRLNIIIIAEGAIDrngkpisSSYVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAV 394
Cdd:pfam00365 202 EKI-KELRKGKRFSIIVVAEGASD-------GEFLAKLIEEGTGIETRVTVLGHVQRGGTPSAFDRILATRLGVKAV 270
|
|
| PFK |
pfam00365 |
Phosphofructokinase; |
475-756 |
2.57e-121 |
|
Phosphofructokinase;
Pssm-ID: 459783 [Multi-domain] Cd Length: 271 Bit Score: 367.44 E-value: 2.57e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 475 LAILNVGAPAAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRTLPKGQLES-- 552
Cdd:pfam00365 2 IGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEGDIDELTWRDVSGILNRGGTILGTSRSKPFKTEEGre 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 553 -IVENIRIYGIHALLVVGGFEAYEGVLQLVEARGryeelcIVMCVIPATISNNVPGTDFSLGSDTAVNAAMESCDRIKQS 631
Cdd:pfam00365 82 kIAENLKKLGIDALVVIGGDGSLTGANKLSEERG------IPVVGIPKTIDNDIPGTDYTIGFDTALNTIVEAIDRIRDT 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 632 ASGTkRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIHDLKVNVEHMTeKMKTDIqrgLVLRNEKCHDyytTEF 711
Cdd:pfam00365 156 ASSH-NRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFDIEELCEKIKELR-KGKRFS---IIVVAEGASD---GEF 227
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 578836565 712 LYNLYssEGKGVFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKAM 756
Cdd:pfam00365 228 LAKLI--EEGTGIETRVTVLGHVQRGGTPSAFDRILATRLGVKAV 270
|
|
| PfkA |
COG0205 |
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ... |
79-431 |
1.77e-107 |
|
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 439975 [Multi-domain] Cd Length: 344 Bit Score: 333.97 E-value: 1.77e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 79 GMNAAVRAVTRMGIYVGAKVFLIYEeqrmpyclspsprgrfgarppswGYEGLVEGgeNIKQANWLSVSNIIQLGGTIIG 158
Cdd:COG0205 15 GLNAAIRAVVRTAIKYGIEVYGIRD-----------------------GYEGLLEG--DIIDLTREDVSGILQRGGTILG 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 159 SARCKAFTTREGRRAAAYNLVQHGITNLCVIGGDGSLTGANIFRSEWGslleelvaegkisettartyshLNIAGLVGSI 238
Cdd:COG0205 70 SSRSKPFKTEEGREKALENLKKLGIDALVVIGGDGSLDGAAKLAEEYG----------------------IPVVGIPKTI 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 239 DNDFCGTDMTIGTDSALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEdgwENFMCE 318
Cdd:COG0205 128 DNDLPGTDYTIGFDTAVNTAAEAIDRLRDTAASHERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFD---LDKLLE 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 319 RLGETRSRGSRLNIIIIAEGAIDRNGKPISSS---------------YVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDR 383
Cdd:COG0205 205 KLKERRKRGKGYSIIVVAEGAGDEDGEAVLEAdtdafghvrlggigeYLAKEIEERTGIETRVTVLGHLQRGGSPSAFDR 284
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 578836565 384 ILSSKMGMEAVMALLEatpDTPACVVTLSGNQSVRLPLMECVQMTKEV 431
Cdd:COG0205 285 VLASRLGAAAVELLLE---GKTGVMVGIRRGEIVLVPLEEVANKEKPV 329
|
|
| PRK03202 |
PRK03202 |
ATP-dependent 6-phosphofructokinase; |
79-438 |
5.47e-106 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235111 [Multi-domain] Cd Length: 320 Bit Score: 329.35 E-value: 5.47e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 79 GMNAAVRAVTRMGIYVGAKVFLIYEeqrmpyclspsprgrfgarppswGYEGLVEGgeNIKQANWLSVSNIIQLGGTIIG 158
Cdd:PRK03202 15 GMNAAIRAVVRTAISEGLEVYGIYD-----------------------GYAGLLEG--DIVKLDLKSVSDIINRGGTILG 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 159 SARCKAFTTREGRRAAAYNLVQHGITNLCVIGGDGSLTGANIFrSEWGslleelvaegkisettartyshLNIAGLVGSI 238
Cdd:PRK03202 70 SARFPEFKDEEGRAKAIENLKKLGIDALVVIGGDGSYMGAKRL-TEHG----------------------IPVIGLPGTI 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 239 DNDFCGTDMTIGTDSALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAP--PEDgwenfM 316
Cdd:PRK03202 127 DNDIAGTDYTIGFDTALNTAVEAIDRLRDTASSHERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPfdIEE-----L 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 317 CERLGETRSRGSRLNIIIIAEGAIDRNGkpisssyVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMA 396
Cdd:PRK03202 202 CAKIKKGRERGKKHAIIVVAEGVMPAEE-------LAKEIEERTGLETRVTVLGHIQRGGSPTAFDRVLASRMGAHAVEL 274
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 578836565 397 LLEATPDTpacVVTLSGNQSVRLPLMECV-QMTKEVQKAMDDK 438
Cdd:PRK03202 275 LLEGKGGR---MVGIQNNKIVHVPIEEAVeNMKHPFDKDLYEL 314
|
|
| PFKA_ATP |
TIGR02482 |
6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate ... |
79-423 |
3.62e-97 |
|
6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate from ATP to fructose 6-phosphate to give fructose 1,6-bisphosphate. This represents a key control step in glycolysis. This model hits bacterial ATP-dependent 6-phosphofructokinases which lack a beta-hairpin loop present in TIGR02483 family members. TIGR02483 contains members that are ATP-dependent as well as members that are pyrophosphate-dependent. TIGR02477 represents the pyrophosphate-dependent phosphofructokinase, diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90). [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 213713 [Multi-domain] Cd Length: 301 Bit Score: 305.43 E-value: 3.62e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 79 GMNAAVRAVTRMGIYVGAKVFLIYEeqrmpyclspsprgrfgarppswGYEGLVEGgeNIKQANWLSVSNIIQLGGTIIG 158
Cdd:TIGR02482 13 GMNAAIRAVVRTAIYHGFEVYGIRR-----------------------GYKGLING--KIEPLESKNVSGIIHRGGTILG 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 159 SARCKAFTTREGRRAAAYNLVQHGITNLCVIGGDGSLTGANIfrsewgslleeLVAEGKIsettartyshlNIAGLVGSI 238
Cdd:TIGR02482 68 TARCPEFKTEEVREKAVENLKKLGIEGLVVIGGDGSYTGAQK-----------LYEEGGI-----------PVIGLPGTI 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 239 DNDFCGTDMTIGTDSALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEA--PPEDgwenfM 316
Cdd:TIGR02482 126 DNDIPGTDYTIGFDTALNTIIDAVDKIRDTATSHERAFVIEVMGRHAGDLALYAGIATGAEIIIIPEFdyDIDE-----L 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 317 CERLGETRSRGSRLNIIIIAEGAIDRNGKPISSSyVKDlvvqRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMA 396
Cdd:TIGR02482 201 IQRLKEQHEAGKKHSIIIVAEGNIVGSAKEVAKK-IEE----KTGIETRVTVLGHTQRGGSPSAFDRVLASRLGAKAVEL 275
|
330 340
....*....|....*....|....*..
gi 578836565 397 LLEatpDTPACVVTLSGNQSVRLPLME 423
Cdd:TIGR02482 276 LLE---GKGGVMIGIQNNKIVTHPIEE 299
|
|
| Bacterial_PFK |
cd00763 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
79-438 |
2.14e-83 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.
Pssm-ID: 238388 [Multi-domain] Cd Length: 317 Bit Score: 269.66 E-value: 2.14e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 79 GMNAAVRAVTRMGIYVGAKVFLIYEeqrmpyclspsprgrfgarppswGYEGLVEGgeNIKQANWLSVSNIIQLGGTIIG 158
Cdd:cd00763 14 GMNAAIRGVVRSAIAEGLEVYGIRD-----------------------GYAGLIAG--DIVPLDRYSVSDIINRGGTFLG 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 159 SARCKAFTTREGRRAAAYNLVQHGITNLCVIGGDGSLTGAnifrsewgsllEELVAEGkisettartyshLNIAGLVGSI 238
Cdd:cd00763 69 SARFPEFKDEEGQAKAIEQLKKHGIDALVVIGGDGSYMGA-----------MRLTEHG------------FPCVGLPGTI 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 239 DNDFCGTDMTIGTDSALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAP--PEDgwenfM 316
Cdd:cd00763 126 DNDIPGTDYTIGFDTALNTVVEAIDRIRDTSSSHQRISVVEVMGRHCGDIALAAGIAGGAEFIVIPEAEfdREE-----V 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 317 CERLGETRSRGSRLNIIIIAEGAIDRNGkpisssyVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMA 396
Cdd:cd00763 201 ANRIKAGIERGKKHAIVVVAEGVYDVDE-------LAKEIEEATGFETRATVLGHIQRGGSPTAFDRILASRMGAYAVEL 273
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 578836565 397 LLEAtpdTPACVVTLSGNQSVRLPLMECVQMTKEVQKAMDDK 438
Cdd:cd00763 274 LLAG---KGGLAVGIQNEQLVHHDIIDAIENMKPFKKDWLAL 312
|
|
| PfkA |
COG0205 |
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ... |
475-761 |
9.34e-68 |
|
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 439975 [Multi-domain] Cd Length: 344 Bit Score: 228.81 E-value: 9.34e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 475 LAILNVGAPAAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRTLPK---GQLE 551
Cdd:COG0205 4 IGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEGDIIDLTREDVSGILQRGGTILGSSRSKPFkteEGRE 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 552 SIVENIRIYGIHALLVVGGFEAYEGVLQLVEARGryeelciVMCV-IPATISNNVPGTDFSLGSDTAVNAAMESCDRIKQ 630
Cdd:COG0205 84 KALENLKKLGIDALVVIGGDGSLDGAAKLAEEYG-------IPVVgIPKTIDNDLPGTDYTIGFDTAVNTAAEAIDRLRD 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 631 SASGTkRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIHDLkvnVEHMTEKMKTDIQRGLVL--------RNEK 702
Cdd:COG0205 157 TAASH-ERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFDLDKL---LEKLKERRKRGKGYSIIVvaegagdeDGEA 232
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 578836565 703 CHDYYTTEFLYNLYSSEGKGV---------FDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKAMLWLSE 761
Cdd:COG0205 233 VLEADTDAFGHVRLGGIGEYLakeieertgIETRVTVLGHLQRGGSPSAFDRVLASRLGAAAVELLLE 300
|
|
| PRK03202 |
PRK03202 |
ATP-dependent 6-phosphofructokinase; |
475-755 |
1.77e-66 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235111 [Multi-domain] Cd Length: 320 Bit Score: 224.57 E-value: 1.77e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 475 LAILNVGAPAAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRT----LPKGQL 550
Cdd:PRK03202 4 IGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEGDIVKLDLKSVSDIINRGGTILGSARFpefkDEEGRA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 551 EsIVENIRIYGIHALLVVGGFEAYEGVLQLVEARgryeelciVMCV-IPATISNNVPGTDFSLGSDTAVNAAMESCDRIK 629
Cdd:PRK03202 84 K-AIENLKKLGIDALVVIGGDGSYMGAKRLTEHG--------IPVIgLPGTIDNDIAGTDYTIGFDTALNTAVEAIDRLR 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 630 QSASgTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIHDLkvnVEHMTEKMKTDIQRGLVLRNEKCHD--YY 707
Cdd:PRK03202 155 DTAS-SHERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFDIEEL---CAKIKKGRERGKKHAIIVVAEGVMPaeEL 230
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 578836565 708 TTEFlynlyssEGKGVFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKA 755
Cdd:PRK03202 231 AKEI-------EERTGLETRVTVLGHIQRGGSPTAFDRVLASRMGAHA 271
|
|
| PFK_mixed |
TIGR02483 |
phosphofructokinase; Members of this family that are characterized, save one, are ... |
79-425 |
1.58e-65 |
|
phosphofructokinase; Members of this family that are characterized, save one, are phosphofructokinases dependent on pyrophosphate (EC 2.7.1.90) rather than ATP (EC 2.7.1.11). The exception is one of three phosphofructokinases from Streptomyces coelicolor. Family members are both bacterial and archaeal. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 274155 [Multi-domain] Cd Length: 324 Bit Score: 222.18 E-value: 1.58e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 79 GMNAAVRAVTRMGIYV-GAKVFLIYEeqrmpyclspsprgrfgarppswGYEGLVEGGEnIKQANWLSVSNIIQLGGTII 157
Cdd:TIGR02483 13 GLNAVIRGVVRRAIAEyGWEVIGIRD-----------------------GWRGLLEGDT-VPLLDLEDVRGILPRGGTIL 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 158 GSARCKAFTT-REGRRAAAYNLVQHGITNLCVIGGDGSLTGANifrsewgslleELVAEGkisettartyshLNIAGLVG 236
Cdd:TIGR02483 69 GSSRTNPFKYeEDGDDKIVANLKELGLDALIAIGGDGTLGIAR-----------RLADKG------------LPVVGVPK 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 237 SIDNDFCGTDMTIGTDSALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEdgWENfM 316
Cdd:TIGR02483 126 TIDNDLEATDYTFGFDTAVEIATEALDRLHTTAESHHRVMVVEVMGRHAGWIALHSGIAGGADVILIPEIPFD--IDS-V 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 317 CERLGETRSRGSRLNIIIIAEGAIDRNGKPISSSYVKD----------------LVVQRLGFDTRVTVLGHVQRGGTPSA 380
Cdd:TIGR02483 203 CEKVRERFARGKRFAIVVVAEGAKPKGGEMVVQEGVKDafghvrlggignwlaeEIERRTGIETRATVLGHLQRGGSPSA 282
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 578836565 381 FDRILSSKMGMEAVMALLEATPDTpacVVTLSGNQSVRLPLMECV 425
Cdd:TIGR02483 283 FDRVLATRFGVAAVDLVHEGQFGH---MVALRGTDIVYVPIAEAV 324
|
|
| PFK |
cd00363 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
474-798 |
2.35e-60 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.
Pssm-ID: 238216 [Multi-domain] Cd Length: 338 Bit Score: 208.31 E-value: 2.35e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 474 SLAILNVGAPAAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRT----LPKGQ 549
Cdd:cd00363 2 KIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIYEGYAGLVEGDIKELDWESVSDIINRGGTIIGSARCkefrTEEGR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 550 LESIvENIRIYGIHALLVVGGFEAYEGVLQLVE-ARGRYEELCIVMCviPATISNNVPGTDFSLGSDTAVNAAMESCDRI 628
Cdd:cd00363 82 AKAA-ENLKKHGIDALVVIGGDGSYTGADLLTEeWPSKYQGFNVIGL--PGTIDNDIKGTDYTIGFDTALKTIVEAIDRI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 629 KQSASgTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNihdlKVNVEHMTEKMKTDIQRG----LVLRNEKch 704
Cdd:cd00363 159 RDTAS-SHQRTFVVEVMGRHCGDIALEAGLATGADIIFIPEEPAA----DEWEEEMVDVIKKRRERGkrhgIVIVAEG-- 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 705 dyyTTEFLYNLYSSEG-------KGVFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKAMLWLSEKLREVyrkgrvfanap 777
Cdd:cd00363 232 ---AIDFIPKPITEKLlaklveeRLGFDTRATVLGHVQRGGTPTAFDRILASRLGAEAVELLLEGTGGT----------- 297
|
330 340
....*....|....*....|.
gi 578836565 778 dSACVIGLKKKAVAFSPVTEL 798
Cdd:cd00363 298 -PVGIQNLNENQVVRHPLTEA 317
|
|
| Bacterial_PFK |
cd00763 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
475-755 |
6.35e-58 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.
Pssm-ID: 238388 [Multi-domain] Cd Length: 317 Bit Score: 201.10 E-value: 6.35e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 475 LAILNVGAPAAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKR----TLPKGQL 550
Cdd:cd00763 3 IGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIRDGYAGLIAGDIVPLDRYSVSDIINRGGTFLGSARfpefKDEEGQA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 551 ESIvENIRIYGIHALLVVGGFEAYEGVLQLVEARgryeelciVMCV-IPATISNNVPGTDFSLGSDTAVNAAMESCDRIK 629
Cdd:cd00763 83 KAI-EQLKKHGIDALVVIGGDGSYMGAMRLTEHG--------FPCVgLPGTIDNDIPGTDYTIGFDTALNTVVEAIDRIR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 630 QSASgTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIHDLKVNVEHMTEKMKtdiQRGLVLRNEkcHDYYTT 709
Cdd:cd00763 154 DTSS-SHQRISVVEVMGRHCGDIALAAGIAGGAEFIVIPEAEFDREEVANRIKAGIERGK---KHAIVVVAE--GVYDVD 227
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 578836565 710 EFLYNLyssEGKGVFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKA 755
Cdd:cd00763 228 ELAKEI---EEATGFETRATVLGHIQRGGSPTAFDRILASRMGAYA 270
|
|
| 6PF1K_euk |
TIGR02478 |
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ... |
475-808 |
1.10e-48 |
|
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).
Pssm-ID: 274152 [Multi-domain] Cd Length: 746 Bit Score: 184.85 E-value: 1.10e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 475 LAILNVGAPAAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKGQ--VQEVGWHDVAGWLGRGGSMLGTKRTLP----KG 548
Cdd:TIGR02478 3 IAVLTSGGDAQGMNAAVRAVVRMAIYVGCRVYAIREGYQGLVDGGdnIEEAQWEDVRGILSLGGTIIGTARCKEfrerPG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 549 QLESiVENIRIYGIHALLVVGGFEAYEG-----------VLQLV-------EARGRYEELCIVMCVipATISNNVPGTDF 610
Cdd:TIGR02478 83 RLKA-ARNLVSNGIDALVVIGGDGSLTGadlfreewpslLEELVdtgkitaEQAEEHRHLTIVGLV--GSIDNDMCGTDM 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 611 SLGSDTAVNAAMESCDRIKQSASGTKrRVFIVETMGGYCGYLATVTGIAVGADaaYVF--EDPfnihdLKVN-VEHMTEK 687
Cdd:TIGR02478 160 TIGADSALHRICEAIDAISSTAQSHQ-RAFVVEVMGRHCGYLALMAAIATGAD--YVFipERP-----PEEGwEDQLCHK 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 688 MKTDIQRG----LVLRNEKCHD----YYTTEFLYNLYSSEGKgvFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKAMLWL 759
Cdd:TIGR02478 232 LKRNRKAGkrktIVIVAEGAIDrdlnPITSEDVKDVLVERLG--LDTRITVLGHVQRGGAPSAFDRILATRQGVEAVLAV 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 578836565 760 SEKLREvyrkgrvfanAPdsACVIGLKK---------KAVAFS-PVTELKKDTDFEHRM 808
Cdd:TIGR02478 310 LESTPE----------TP--SPVISLRGnkivrkplvEAVAQTkTVAKAIEEKDFDEAM 356
|
|
| 6PF1K_euk |
TIGR02478 |
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ... |
78-415 |
9.85e-47 |
|
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).
Pssm-ID: 274152 [Multi-domain] Cd Length: 746 Bit Score: 179.07 E-value: 9.85e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 78 GGMNAAVRAVTRMGIYVGAKVFLIYEeqrmpyclspsprgrfgarppswGYEGLVEGGenIKQANWLSVSNIIQLGGTII 157
Cdd:TIGR02478 402 GGMNAATRSAVRYALARGHTVIAIHN-----------------------GFSGLARHD--VRELTWSDVEGWVGEGGSEL 456
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 158 GSARCkafTTREGRRAAAYNLVQHGITNLCVIGGDGSLTGANIFRsewgslleelvaegkisetTART-YSHLNI--AGL 234
Cdd:TIGR02478 457 GTNRS---LPGDDLGTIAYYFQQHKIDGLIIIGGFEAFEALYQLD-------------------AAREkYPAFRIpmVVI 514
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 235 VGSIDNDFCGTDMTIGTDSALHRIMEVIDAITTTAQ-SHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAP-PEDGW 312
Cdd:TIGR02478 515 PATISNNVPGTEYSLGSDTALNEITEYCDNIKQSASaSKRRVFVVETMGGYSGYLATMAGLATGADAAYIPEEGiSLKDL 594
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 313 EN---FMCERLGETRSRGsrlnIIIIAEGAIdrngKPISSSYVKDLVVQ--RLGFDTRVTVLGHVQRGGTPSAFDRILSS 387
Cdd:TIGR02478 595 QEdieHLKETFAEGRAGK----LILRNEKAS----KVYTTDFIARIISEegKGRFDARTAVLGHMQQGGSPSPFDRVRAT 666
|
330 340 350
....*....|....*....|....*....|....*....
gi 578836565 388 KMGMEAVMALLEATP-----------DTPACVVTLSGNQ 415
Cdd:TIGR02478 667 RLAIRAVDFIEEKIKankhadklsadDTSAVVIGIRGSN 705
|
|
| PRK14071 |
PRK14071 |
ATP-dependent 6-phosphofructokinase; |
78-432 |
7.24e-45 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 184487 [Multi-domain] Cd Length: 360 Bit Score: 165.63 E-value: 7.24e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 78 GGMNAAVRAVTR--MGIYvGAKVFLIYEeqrmpyclspsprGRFG--ARPPSwgYEGLveggeNIKQanwlsVSNIIQLG 153
Cdd:PRK14071 17 AGLNAVIRAVVHraRGTY-GWEVIGIRD-------------ATQGlmARPPQ--YIEL-----DLDQ-----VDDLLRMG 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 154 GTIIGSARcK----AFTTREG----RRA---AAYNlvQHGITNLCVIGGDGSLtganifrsewgSLLEELVAEGKIsett 222
Cdd:PRK14071 71 GTILGTTN-KgdpfAFPMPDGslrdRSQeiiDGYH--SLGLDALIGIGGDGSL-----------AILRRLAQQGGI---- 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 223 artyshlNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLF 302
Cdd:PRK14071 133 -------NLVGIPKTIDNDVGATEVSIGFDTAVNIATEALDRLHFTAASHNRVMILEVMGRDAGHIALAAGIAGGADVIL 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 303 IPEAPPEdgWENfMCERLGETRSRGSRLNIIIIAEGAIDRNGKPIS-------------SSYVKDLVVQRLGFDTRVTVL 369
Cdd:PRK14071 206 IPEIPYT--LEN-VCKKIRERQEEGKNFCLVVVSEAVRTEEGEQVTktqalgedryggiGQYLAEQIAERTGAETRVTVL 282
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578836565 370 GHVQRGGTPSAFDRILSSKMGMEAVMALLEATPDTpacVVTLSGNQSVRLPLMECVQMTKEVQ 432
Cdd:PRK14071 283 GHIQRGGIPSPRDRLLASAFGVAAVDLIAQGKFDR---MVAWQNRQVVSVPIAEAIATYRAVD 342
|
|
| Eukaryotic_PFK |
cd00764 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
474-818 |
2.79e-44 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.
Pssm-ID: 238389 [Multi-domain] Cd Length: 762 Bit Score: 171.93 E-value: 2.79e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 474 SLAILNVGAPAAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKG--QVQEVGWHDVAGWLGRGGSMLGTKR----TLPK 547
Cdd:cd00764 5 AIAVLTSGGDAQGMNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKGgdYIKQAEWESVSNWLQEGGTIIGSARckefRERE 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 548 GQLESIVeNIRIYGIHALLVVGGFEAYEG-----------VLQLV-------EARGRYEELCIVMCVipATISNNVPGTD 609
Cdd:cd00764 85 GRLQAAY-NLIQRGITNLCVIGGDGSLTGadlfrsewpslLEELVkdgkiteEEVAKYQHLNIVGMV--GSIDNDFCGTD 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 610 FSLGSDTAVNAAMESCDRIKQSASgTKRRVFIVETMGGYCGYLATVTGIAVGADaaYVF------EDPFNIHDLKVNVEH 683
Cdd:cd00764 162 MTIGTDSALHRICEVVDAITTTAQ-SHQRTFVLEVMGRHCGYLALVSGLATGAD--WIFiperppEDGWEDQMCRRLSEH 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 684 MTEKMKTDI---QRGLVLRNEKChdyYTTEFLYNLYSSEGKgvFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKAMLWLS 760
Cdd:cd00764 239 RSRGKRLNIiivAEGAIDDQLKP---ITSEDVKDLVVERLG--LDTRVTTLGHVQRGGTPSAFDRILASLMGVEAVMALL 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578836565 761 EklrevyrkgrvfaNAPDS-ACVIGLKKKAVAFSPVTE---LKKDTDFEHRMPREQWWLSLR 818
Cdd:cd00764 314 E-------------ATPDTpACVVSLNGNKAVRLPLMEcvqLTKDVQKAMDEKRFDEAAALR 362
|
|
| Eukaryotic_PFK |
cd00764 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
78-394 |
2.93e-39 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.
Pssm-ID: 238389 [Multi-domain] Cd Length: 762 Bit Score: 156.52 E-value: 2.93e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 78 GGMNAAVRAVTRMGIYVGAKVFLIYEeqrmpyclspsprgrfgarppswGYEGLVEGGenIKQANWLSVSNIIQLGGTII 157
Cdd:cd00764 402 AGMNAAVRSAVRYGLAHGHRPYAIYD-----------------------GFEGLAKGQ--IVELGWIDVGGWTGRGGSEL 456
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 158 GSARCkafTTREGRRAAAYNLVQHGITNLCVIGGDGSLTGanifrsewgsLLEELVAEGKisettartYSHLNIAGLV-- 235
Cdd:cd00764 457 GTKRT---LPKKDLETIAYNFQKYGIDGLIIVGGFEAYKG----------LLQLREAREQ--------YEEFCIPMVLip 515
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 236 GSIDNDFCGTDMTIGTDSALHRIMEVIDAITTTAQS-HQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAP--PEDGW 312
Cdd:cd00764 516 ATVSNNVPGTDFSLGSDTALNALMKYCDRIKQSASGtKRRVFIVETMGGYCGYLATMTGLAVGADAAYVFEEPfnIRDLQ 595
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 313 ENF--MCERLGETRSRGSRLNIIIIAEGAIDRNGKPISSSYVKDLvvqrlgFDTRVTVLGHVQRGGTPSAFDRILSSKMG 390
Cdd:cd00764 596 ENVehLTEKMKTTIGRGLVLRNEKCNENYTTVFTYELYSEEGKGV------FDCRTNVLGHVQQGGAPSPFDRNFGTKFA 669
|
....
gi 578836565 391 MEAV 394
Cdd:cd00764 670 VKAM 673
|
|
| PRK14071 |
PRK14071 |
ATP-dependent 6-phosphofructokinase; |
477-755 |
8.72e-31 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 184487 [Multi-domain] Cd Length: 360 Bit Score: 124.80 E-value: 8.72e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 477 ILNVGAPAAGMNAAVRSAVRTGISH-GHTVYVVHDGFEGLAKG--QVQEVGWHDVAGWLGRGGSMLGTKRT-------LP 546
Cdd:PRK14071 9 ILTSGGDCAGLNAVIRAVVHRARGTyGWEVIGIRDATQGLMARppQYIELDLDQVDDLLRMGGTILGTTNKgdpfafpMP 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 547 KGQL----ESIVENIRIYGIHALLVVGGfeayEGVLQLVEargryeELC----IVMCVIPATISNNVPGTDFSLGSDTAV 618
Cdd:PRK14071 89 DGSLrdrsQEIIDGYHSLGLDALIGIGG----DGSLAILR------RLAqqggINLVGIPKTIDNDVGATEVSIGFDTAV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 619 NAAMESCDRIKQSASgTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIhdlkvnvEHMTEKMKTDIQRG--- 695
Cdd:PRK14071 159 NIATEALDRLHFTAA-SHNRVMILEVMGRDAGHIALAAGIAGGADVILIPEIPYTL-------ENVCKKIRERQEEGknf 230
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578836565 696 -LVLRNEKCHDY------YTTEFLYNLYSSEGKGVFD---------CRTNVLGHLQQGGAPTPFDRNYGTKLGVKA 755
Cdd:PRK14071 231 cLVVVSEAVRTEegeqvtKTQALGEDRYGGIGQYLAEqiaertgaeTRVTVLGHIQRGGIPSPRDRLLASAFGVAA 306
|
|
| PTZ00286 |
PTZ00286 |
6-phospho-1-fructokinase; Provisional |
79-339 |
4.57e-24 |
|
6-phospho-1-fructokinase; Provisional
Pssm-ID: 185539 Cd Length: 459 Bit Score: 106.28 E-value: 4.57e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 79 GMNAAVRAVTRMGIYVgakvfliYEEQRMpyclspsprgrFGARppsWGYEGLVEggENIKQANWLSVSNIIQLGGTIIG 158
Cdd:PTZ00286 101 GLNVVIRELVMNLINN-------YGVKTI-----------YGAK---YGYKGLYK--EDWIKLDPKDVKTIHRLGGTILG 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 159 SARcKAFTTREgrraAAYNLVQHGITNLCVIGGDGSLTGANifrsewgSLLEELVAEG-KISettartyshlnIAGLVGS 237
Cdd:PTZ00286 158 SSR-GGFDPKV----MVDTLIRHGINILFTLGGDGTHRGAL-------AIYKELRRRKlNIS-----------VVGIPKT 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 238 IDNDFCGTDMTIGTDSALHRIMEVIDAITTTAQSHQRTF-VLEVMGRHCGYLALVSALASG-ADWLFIPEAP-PEDGWEN 314
Cdd:PTZ00286 215 IDNDIPIIDESFGFQTAVEEAQNAIRAAYVEAKSAKNGVgIVKLMGRDSGFIALHASVASAdVNVCLIPEFDiPLEGVLE 294
|
250 260
....*....|....*....|....*
gi 578836565 315 FMCERLGETRSRgsrlnIIIIAEGA 339
Cdd:PTZ00286 295 YIEQRLQKKGHC-----VIVVAEGA 314
|
|
| PTZ00286 |
PTZ00286 |
6-phospho-1-fructokinase; Provisional |
467-674 |
5.01e-18 |
|
6-phospho-1-fructokinase; Provisional
Pssm-ID: 185539 Cd Length: 459 Bit Score: 87.79 E-value: 5.01e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 467 PKEKSNFS-----LAILNVGAPAAGMNAAVRSAVRTGIS--HGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSML 539
Cdd:PTZ00286 77 PRKHLYFNpkevkAGIVTCGGLCPGLNVVIRELVMNLINnyGVKTIYGAKYGYKGLYKEDWIKLDPKDVKTIHRLGGTIL 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 540 GTKRTlpkGQ-LESIVENIRIYGIHALLVVGGFEAYEGVLQL-VEARGRYEELCIvmCVIPATISNNVPGTDFSLGSDTA 617
Cdd:PTZ00286 157 GSSRG---GFdPKVMVDTLIRHGINILFTLGGDGTHRGALAIyKELRRRKLNISV--VGIPKTIDNDIPIIDESFGFQTA 231
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 578836565 618 VNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTGIAVG-ADAAYVFEDPFNI 674
Cdd:PTZ00286 232 VEEAQNAIRAAYVEAKSAKNGVGIVKLMGRDSGFIALHASVASAdVNVCLIPEFDIPL 289
|
|
| PRK06830 |
PRK06830 |
ATP-dependent 6-phosphofructokinase; |
127-339 |
1.87e-17 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235869 Cd Length: 443 Bit Score: 86.08 E-value: 1.87e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 127 GYEGLV-EGGENIKQANWLSVSNIIQLGGTIIGSARckafttreGRRAAAY---NLVQHGITNLCVIGGDGSLTGANifr 202
Cdd:PRK06830 121 GYQGLIpRYGHDPVELTPEVVADIHEFGGTILGSSR--------GPQDPEEivdTLERMNINILFVIGGDGTLRGAS--- 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 203 sewgslleelvaegKISETTARtySHLNIAgLVG---SIDNDFCGTDMTIGTDSALHRIMEVIDAITTTAQSHQRTFVL- 278
Cdd:PRK06830 190 --------------AIAEEIER--RGLKIS-VIGipkTIDNDINFIQKSFGFETAVEKATEAIRCAHVEANGAPNGIGLv 252
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578836565 279 EVMGRHCGYLALVSALASG-ADWLFIPEAPPE-DGWENFMcERLgETRSRGSRLNIIIIAEGA 339
Cdd:PRK06830 253 KLMGRHSGFIAAYAALASKdVNFVLIPEVPFDlEGPNGLL-AAL-EKRLAERGHAVIVVAEGA 313
|
|
| PRK14072 |
PRK14072 |
diphosphate--fructose-6-phosphate 1-phosphotransferase; |
238-405 |
5.64e-15 |
|
diphosphate--fructose-6-phosphate 1-phosphotransferase;
Pssm-ID: 237600 [Multi-domain] Cd Length: 416 Bit Score: 77.98 E-value: 5.64e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 238 IDNDFCGTDMTIGTDSALHRI----MEV-IDAITTTAQShqRTFVLEVMGRHCGYLALVSALAS-----GADWLFIPEAP 307
Cdd:PRK14072 142 IDNDLPGTDHCPGFGSAAKYIatsvLEAaLDVAAMANTS--KVFILEVMGRHAGWLAAAAALAKqnpddAPHLIYLPERP 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 308 PEDgwENFMcERLGETRSRGSRLnIIIIAEGAIDRNGKPISSS-----------------YVKDLVVQRLGFDTRVTVLG 370
Cdd:PRK14072 220 FDE--EKFL-ADVRAIVKRYGYC-VVVVSEGIRDADGKFIAEAglaedafghaqlggvapVLANLIKEKLGKKVHWAVLD 295
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 578836565 371 HVQR--GGTPSAFDR---ILSSKM-------GMEAVMALLEATPDTP 405
Cdd:PRK14072 296 YLQRaaRHIASKTDVeeaYAVGKAaveyalaGKNGVMPAIRRTSDDP 342
|
|
| PLN02564 |
PLN02564 |
6-phosphofructokinase |
145-339 |
8.33e-15 |
|
6-phosphofructokinase
Pssm-ID: 178178 Cd Length: 484 Bit Score: 77.87 E-value: 8.33e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 145 SVSNIIQLGGTIIGSARCKAFTTRegrraAAYNLVQHGITNLCVIGGDGSLTGANifrsewgSLLEELVAEG-KISetta 223
Cdd:PLN02564 144 VVNDIHKRGGTILGTSRGGHDTSK-----IVDSIQDRGINQVYIIGGDGTQKGAS-------VIYEEIRRRGlKVA---- 207
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 224 rtyshlnIAGLVGSIDNDFCGTDMTIGTDSALHRIMEVIDAITTTAQS-HQRTFVLEVMGRHCGYLALVSALAS-GADWL 301
Cdd:PLN02564 208 -------VAGIPKTIDNDIPVIDKSFGFDTAVEEAQRAINAAHVEAESvENGIGLVKLMGRYSGFIAMYATLASrDVDCC 280
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 578836565 302 FIPEAP----PEDGWENFMCERLGETRSRgsrlnIIIIAEGA 339
Cdd:PLN02564 281 LIPESPfyleGKGGLFEFIEKRLKENGHM-----VIVVAEGA 317
|
|
| PLN02884 |
PLN02884 |
6-phosphofructokinase |
463-687 |
1.26e-11 |
|
6-phosphofructokinase
Pssm-ID: 178472 [Multi-domain] Cd Length: 411 Bit Score: 67.53 E-value: 1.26e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 463 HQKPPKEKSNF-----SLAILNVGAPAAGMNAAVRSAVRT----------GISHGHTvyvvhdGF--EGLA-----KGQV 520
Cdd:PLN02884 39 HRAGPRKKIYFepeevKAAIVTCGGLCPGLNDVIRQIVFTleiygvknivGIPFGYR------GFfeKGLSemplsRKVV 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 521 QEVGWHdvagwlgrGGSMLGTKRTLPKgqLESIVENIRIYGIHALLVVGGFEAYEGVLQL-VEARGRYEELCIVmCViPA 599
Cdd:PLN02884 113 QNIHLS--------GGSLLGVSRGGAK--TSDIVDSIEARGINMLFVLGGNGTHAGANAIhNECRKRKMKVSVV-GV-PK 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 600 TISNNVPGTDFSLGSDTAVNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTGIAVG-ADAAYVFEDPFNIH--- 675
Cdd:PLN02884 181 TIDNDILLMDKTFGFDTAVEEAQRAINSAYIEAHSAYHGIGLVKLMGRSSGFIAMHASLASGqVDICLIPEVPFTLDgpn 260
|
250
....*....|..
gi 578836565 676 DLKVNVEHMTEK 687
Cdd:PLN02884 261 GVLRHLEHLIET 272
|
|
| PLN02884 |
PLN02884 |
6-phosphofructokinase |
125-431 |
1.28e-11 |
|
6-phosphofructokinase
Pssm-ID: 178472 [Multi-domain] Cd Length: 411 Bit Score: 67.53 E-value: 1.28e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 125 SWGYEGLVEggENIKQANwLS---VSNIIQLGGTIIGSARCKAFTTRegrraAAYNLVQHGITNLCVIGGDGSLTGANIf 201
Cdd:PLN02884 91 PFGYRGFFE--KGLSEMP-LSrkvVQNIHLSGGSLLGVSRGGAKTSD-----IVDSIEARGINMLFVLGGNGTHAGANA- 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 202 rsewgslleelvaegkISETTARTYSHLNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEVIDAITTTAQSHQRTF-VLEV 280
Cdd:PLN02884 162 ----------------IHNECRKRKMKVSVVGVPKTIDNDILLMDKTFGFDTAVEEAQRAINSAYIEAHSAYHGIgLVKL 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 281 MGRHCGYLALVSALASG-ADWLFIPEAPPE-DGWENFM--CERLGETRSRGsrlnIIIIAEGA-IDRNGKPISSSYVKDL 355
Cdd:PLN02884 226 MGRSSGFIAMHASLASGqVDICLIPEVPFTlDGPNGVLrhLEHLIETKGSA----VVCVAEGAgQDLLQKTNATDASGNP 301
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 356 VVQRLGFDTRVTVLGHVQRGGTPS-----------------AFDRILSSKMGMEAVMAlleATPDTPACVVTLSGNQSVR 418
Cdd:PLN02884 302 VLGDIGVHLQQEIKKHFKDIGVPAdvkyidptymiracranASDAILCTVLGQNAVHG---AFAGFSGITVGICNTHYVY 378
|
330
....*....|...
gi 578836565 419 LPLMECVQMTKEV 431
Cdd:PLN02884 379 LPIPEVIAYPRRV 391
|
|
| PRK06830 |
PRK06830 |
ATP-dependent 6-phosphofructokinase; |
486-675 |
1.93e-10 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235869 Cd Length: 443 Bit Score: 64.12 E-value: 1.93e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 486 GMNAAVRSAVRTGishgHTVYVVHD------GFEGLakgqVQEVGwHD--------VAGWLGRGGSMLGTKRtlpkGQ-- 549
Cdd:PRK06830 94 GLNDVIRAIVLEL----HHHYGVRRilgiryGYQGL----IPRYG-HDpveltpevVADIHEFGGTILGSSR----GPqd 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 550 LESIVENIRIYGIHALLVVGGFEAYEGVLQLV-EARGRYEELCIVmcVIPATISNNVPGTDFSLGSDTAVNAAMESCDRI 628
Cdd:PRK06830 161 PEEIVDTLERMNINILFVIGGDGTLRGASAIAeEIERRGLKISVI--GIPKTIDNDINFIQKSFGFETAVEKATEAIRCA 238
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 578836565 629 KQSASGTKRRVFIVETMGGYCGYLATVTGIAVgADAAYVF--EDPFNIH 675
Cdd:PRK06830 239 HVEANGAPNGIGLVKLMGRHSGFIAAYAALAS-KDVNFVLipEVPFDLE 286
|
|
| PLN02564 |
PLN02564 |
6-phosphofructokinase |
534-672 |
1.02e-09 |
|
6-phosphofructokinase
Pssm-ID: 178178 Cd Length: 484 Bit Score: 61.69 E-value: 1.02e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 534 RGGSMLGTKRtlpKGQ-LESIVENIRIYGIHALLVVGGFEAYEG---VLQLVEARGryeeLCIVMCVIPATISNNVPGTD 609
Cdd:PLN02564 151 RGGTILGTSR---GGHdTSKIVDSIQDRGINQVYIIGGDGTQKGasvIYEEIRRRG----LKVAVAGIPKTIDNDIPVID 223
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578836565 610 FSLGSDTAVNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTGIAV-GADAAYVFEDPF 672
Cdd:PLN02564 224 KSFGFDTAVEEAQRAINAAHVEAESVENGIGLVKLMGRYSGFIAMYATLASrDVDCCLIPESPF 287
|
|
| PRK06555 |
PRK06555 |
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated |
127-339 |
7.79e-08 |
|
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated
Pssm-ID: 180620 [Multi-domain] Cd Length: 403 Bit Score: 55.40 E-value: 7.79e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 127 GYEGLVeGGENI-------KQANWLSvsniiQLGGTIIGSARCKAFTT---------REGR---RAAAYNLVQHGITNLC 187
Cdd:PRK06555 44 GYQGLL-LGDSIeitpavrANAGLLH-----RYGGSPIGNSRVKLTNVadcvkrglvKEGEnplKVAAERLAADGVDILH 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 188 VIGGDGSLTGAnifrsewGSLLEELVAEGkisettartYsHLNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEVIDAITT 267
Cdd:PRK06555 118 TIGGDDTNTTA-------ADLAAYLAENG---------Y-DLTVVGLPKTIDNDVVPIRQSLGAWTAAEQGARFFDNVIN 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 268 TAQSHQRTFVL-EVMGRHCGYLALVSALA-----SGADWL---------------FIPEAPPEDGWEnfmCERLGETRSR 326
Cdd:PRK06555 181 EHSANPRMLIIhEVMGRNCGWLTAATARAyrewlDRQEYVpgfglsaerwdihavYLPEMAFDLEAE---AERLKAVMDE 257
|
250
....*....|...
gi 578836565 327 GSRLNiIIIAEGA 339
Cdd:PRK06555 258 VGNVN-IFLSEGA 269
|
|
| PRK14072 |
PRK14072 |
diphosphate--fructose-6-phosphate 1-phosphotransferase; |
481-739 |
4.49e-07 |
|
diphosphate--fructose-6-phosphate 1-phosphotransferase;
Pssm-ID: 237600 [Multi-domain] Cd Length: 416 Bit Score: 53.33 E-value: 4.49e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 481 GAPAAGMNAAVRSAVRTGISHG--HTVYVVHDGFEGLAKGQV---QEVGWHDVAGWLGRGGSMLGTKRTLPKG------Q 549
Cdd:PRK14072 12 GGPTAVINASAAGVIEEARKHKkiGKVYGARNGIIGILDEDLidlSKESDEALAALAHTPSGALGSCRYKLKSleedraE 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 550 LESIVENIRIYGIHALLVVGG---FEAYEGVLQLVEARGrYEELCIVmcvIPATISNNVPGTDFSLGSDTAVN----AAM 622
Cdd:PRK14072 92 YERLLEVFKAHDIGYFFYNGGndsMDTALKVSQLAKKMG-YPIRCIG---IPKTIDNDLPGTDHCPGFGSAAKyiatSVL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 623 E-SCDrikQSASGTKRRVFIVETMGGYCGYLATVTGIA-----VGADAAYVFEDPFNIhdlkvnvehmtEKMKTDIQRgL 696
Cdd:PRK14072 168 EaALD---VAAMANTSKVFILEVMGRHAGWLAAAAALAkqnpdDAPHLIYLPERPFDE-----------EKFLADVRA-I 232
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 578836565 697 VLRNEKC--------HDyytteflynlysSEGKGVFD--CRTNVLGHLQQGGA 739
Cdd:PRK14072 233 VKRYGYCvvvvsegiRD------------ADGKFIAEagLAEDAFGHAQLGGV 273
|
|
| PTZ00287 |
PTZ00287 |
6-phosphofructokinase; Provisional |
183-341 |
8.63e-05 |
|
6-phosphofructokinase; Provisional
Pssm-ID: 240345 [Multi-domain] Cd Length: 1419 Bit Score: 46.57 E-value: 8.63e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 183 ITNLCVIGGDGSLTGAnifrsewgSLLEELVAEGKISettartyshLNIAGLVGSIDNDFC--GTDMTIGTDSALHRIME 260
Cdd:PTZ00287 272 LNGLVIIGGDGSNSNA--------ALISEYFAERQIP---------ISIIGIPKTIDGDLKseAIEISFGFDTATKTYSE 334
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 261 VIDAITTTAQS-HQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWE---------NFMCERlgetRSRGSRL 330
Cdd:PTZ00287 335 VIGNLCTDVKTgHNVYHVVRVMGRSASHVVLECALQTRPNIVLIGEEVEKENLSlkdivsnivNTILKR----RSLNKNY 410
|
170
....*....|.
gi 578836565 331 NIIIIAEGAID 341
Cdd:PTZ00287 411 GVILIPEGLIE 421
|
|
| PTZ00468 |
PTZ00468 |
phosphofructokinase family protein; Provisional |
146-341 |
3.71e-04 |
|
phosphofructokinase family protein; Provisional
Pssm-ID: 185647 [Multi-domain] Cd Length: 1328 Bit Score: 44.19 E-value: 3.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 146 VSNIIQLGG-TIIGSARCKaFTTREGRRAAAYNLVQHGITNLCVIGGDGSLTGANIfrsewgslleelvaegkISETTAR 224
Cdd:PTZ00468 160 INGILNQGGfNIICSGRHK-IETEEQMRASLEICEKLKLHGLVVIGGDDSNTNAAV-----------------LAEYFKR 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836565 225 TYSHLNIAGLVGSIDNDFCG--TDMTIGTDSALHRIMEVIDAITTTAQSHQ-RTFVLEVMGRHCGYLALVSALASGADWL 301
Cdd:PTZ00468 222 NSSSTVVVGCPKTIDGDLKNevIETSFGYDTAVKTYSEQIGSIMDAIKTEGyGYYFVRLMGRSASHITLECGLQTRANMI 301
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 578836565 302 FIPEAPPEDGWE-----NFMCERLGETRSRGSRLNIIIIAEGAID 341
Cdd:PTZ00468 302 LIGEEIKEENRSlmsivDEIVEMILKRDSLGKKHGIVLLPEGLIE 346
|
|
| |
