NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|630959874|ref|XP_007876345|]
View 

uncharacterized protein PFL1_00661 [Pseudozyma flocculosa PF-1]

Protein Classification

RING finger protein( domain architecture ID 10640503)

RING finger protein may function as an E3 ubiquitin protein ligase that mediates the ubiquitination of target proteins by bringing the ubiquitin-charged E2 ubiquitin-conjugating enzyme and the acceptor protein together to enable the direct transfer of ubiquitin

CATH:  3.30.40.10
EC:  2.3.2.27
Gene Ontology:  GO:0016567|GO:0061630|GO:0008270
PubMed:  19489725|11007473|22154517
SCOP:  3000160

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
SIP5-like cd24139
SNF1-interacting protein 5 and similar proteins; Sip5 plays a role in the regulation of SNF1 ...
 67-287 3.11e-63

SNF1-interacting protein 5 and similar proteins; Sip5 plays a role in the regulation of SNF1 kinase. It may negatively regulate SNF1 kinase under glucose-limiting conditions, by promoting the interaction of the REG1/GLC7 phosphatase complex with the kinase. It interacts directly with SNF1 kinase and the Reg1 component of the phosphatase complex. Sip5 also physically interacts with the N-terminus of Std1, an accessory subunit of the SNF1 kinase protein complex, in the absence of glucose. This prevents aggregation of Std1 and keeps it bound to SNF1, the catalytic subunit, keeping the SNF1 complex in an active state. Upon addition of glucose, Vhs1 kinase phosphorylates Sip5, inhibiting its binding to Std1. Once Sip5 is released, the N-terminal asparagine-rich part of Std1 aggregates, and Std1 exits the nucleus and localizes to cytoplasmic granules. SNF1 kinase is inactive in this state.


:

Pssm-ID: 467940  Cd Length: 200  Bit Score: 207.52  E-value: 3.11e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874  67 QVDKGGLVPQGVYTGPQDYDQHVVRQAVVDRRLAPFCKGSDDEDTYESEPFN-------------------SECPICFLY 127
Cdd:cd24139    4 TVDGGYLAPQGLYYSPLDYDKPIVRQLIIERKLAPFYKGLQDFDEDWTDEELvaavrlpsddleaqlyrnaVECPICFLY 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874 128 YPSPLNFSRCCHQPICTECFVQMKRADP-----NATNPPS------SEARSCPFCVEPDFGVTYTSPSALEAqkvgpssa 196
Cdd:cd24139   84 YPPNLNYTRCCDQPICTECFVQIKRPDPhpphdHVDPPEEdphlliSEPANCPYCAEPNFGVTYEPPAFRRT-------- 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874 197 aataaagspgsgsssgsdspndasdaanfaeraigtggaagskgsgKKKVLPVDDPAVITVDQVRPDWHVKLAQAQATIA 276
Cdd:cd24139  156 ----------------------------------------------GRQSVSATDPYVVTSDMIRPDWEAKLAAARARLA 189

                        250
                 ....*....|.
gi 630959874 277 RRANRRVIMRQ 287
Cdd:cd24139  190 RRAANATAIHA 200
PRK07003 super family cl35530
DNA polymerase III subunit gamma/tau;
409-601 1.46e-07

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK07003:

Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 54.86  E-value: 1.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874 409 GSSPAPASEATASGSTANAASSGRQHGSAQAPPAPLAGTTVQSRTSPVASASTEAPVRAPPQPQVPAVSAAGLGLSPTTM 488
Cdd:PRK07003 371 GVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADGDAPVP 450

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874 489 ADLSELIEGAAPPPRTSSNARSAPNTTVTAAGSTTAVAPSGSASPAAPAGSRGS--GSPLSSPLRAPRTNLPAPEPVPVP 566
Cdd:PRK07003 451 AKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPaaVPDARAPAAASREDAPAAAAPPAP 530

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 630959874 567 QPVAGMGSAWSEAEAARNARQSLD---KQGVQVSAANG 601
Cdd:PRK07003 531 EARPPTPAAAAPAARAGGAAAALDvlrNAGMRVSSDRG 568
 
Name Accession Description Interval E-value
SIP5-like cd24139
SNF1-interacting protein 5 and similar proteins; Sip5 plays a role in the regulation of SNF1 ...
 67-287 3.11e-63

SNF1-interacting protein 5 and similar proteins; Sip5 plays a role in the regulation of SNF1 kinase. It may negatively regulate SNF1 kinase under glucose-limiting conditions, by promoting the interaction of the REG1/GLC7 phosphatase complex with the kinase. It interacts directly with SNF1 kinase and the Reg1 component of the phosphatase complex. Sip5 also physically interacts with the N-terminus of Std1, an accessory subunit of the SNF1 kinase protein complex, in the absence of glucose. This prevents aggregation of Std1 and keeps it bound to SNF1, the catalytic subunit, keeping the SNF1 complex in an active state. Upon addition of glucose, Vhs1 kinase phosphorylates Sip5, inhibiting its binding to Std1. Once Sip5 is released, the N-terminal asparagine-rich part of Std1 aggregates, and Std1 exits the nucleus and localizes to cytoplasmic granules. SNF1 kinase is inactive in this state.


Pssm-ID: 467940  Cd Length: 200  Bit Score: 207.52  E-value: 3.11e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874  67 QVDKGGLVPQGVYTGPQDYDQHVVRQAVVDRRLAPFCKGSDDEDTYESEPFN-------------------SECPICFLY 127
Cdd:cd24139    4 TVDGGYLAPQGLYYSPLDYDKPIVRQLIIERKLAPFYKGLQDFDEDWTDEELvaavrlpsddleaqlyrnaVECPICFLY 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874 128 YPSPLNFSRCCHQPICTECFVQMKRADP-----NATNPPS------SEARSCPFCVEPDFGVTYTSPSALEAqkvgpssa 196
Cdd:cd24139   84 YPPNLNYTRCCDQPICTECFVQIKRPDPhpphdHVDPPEEdphlliSEPANCPYCAEPNFGVTYEPPAFRRT-------- 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874 197 aataaagspgsgsssgsdspndasdaanfaeraigtggaagskgsgKKKVLPVDDPAVITVDQVRPDWHVKLAQAQATIA 276
Cdd:cd24139  156 ----------------------------------------------GRQSVSATDPYVVTSDMIRPDWEAKLAAARARLA 189

                        250
                 ....*....|.
gi 630959874 277 RRANRRVIMRQ 287
Cdd:cd24139  190 RRAANATAIHA 200
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
409-601 1.46e-07

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 54.86  E-value: 1.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874 409 GSSPAPASEATASGSTANAASSGRQHGSAQAPPAPLAGTTVQSRTSPVASASTEAPVRAPPQPQVPAVSAAGLGLSPTTM 488
Cdd:PRK07003 371 GVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADGDAPVP 450

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874 489 ADLSELIEGAAPPPRTSSNARSAPNTTVTAAGSTTAVAPSGSASPAAPAGSRGS--GSPLSSPLRAPRTNLPAPEPVPVP 566
Cdd:PRK07003 451 AKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPaaVPDARAPAAASREDAPAAAAPPAP 530

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 630959874 567 QPVAGMGSAWSEAEAARNARQSLD---KQGVQVSAANG 601
Cdd:PRK07003 531 EARPPTPAAAAPAARAGGAAAALDvlrNAGMRVSSDRG 568
RING smart00184
Ring finger; E3 ubiquitin-protein ligase activity is intrinsic to the RING domain of c-Cbl and ...
 121-171 3.09e-04

Ring finger; E3 ubiquitin-protein ligase activity is intrinsic to the RING domain of c-Cbl and is likely to be a general function of this domain; Various RING fingers exhibit binding activity towards E2 ubiquitin-conjugating enzymes (Ubc' s)


Pssm-ID: 214546 [Multi-domain]  Cd Length: 40  Bit Score: 38.64  E-value: 3.09e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 630959874   121 CPICFLYYPSPLNFSRCCHQpICTECFVQMKRadpnatnppsSEARSCPFC 171
Cdd:smart00184   1 CPICLEEYLKDPVILPCGHT-FCRSCIRKWLE----------SGNNTCPIC 40
 
Name Accession Description Interval E-value
SIP5-like cd24139
SNF1-interacting protein 5 and similar proteins; Sip5 plays a role in the regulation of SNF1 ...
 67-287 3.11e-63

SNF1-interacting protein 5 and similar proteins; Sip5 plays a role in the regulation of SNF1 kinase. It may negatively regulate SNF1 kinase under glucose-limiting conditions, by promoting the interaction of the REG1/GLC7 phosphatase complex with the kinase. It interacts directly with SNF1 kinase and the Reg1 component of the phosphatase complex. Sip5 also physically interacts with the N-terminus of Std1, an accessory subunit of the SNF1 kinase protein complex, in the absence of glucose. This prevents aggregation of Std1 and keeps it bound to SNF1, the catalytic subunit, keeping the SNF1 complex in an active state. Upon addition of glucose, Vhs1 kinase phosphorylates Sip5, inhibiting its binding to Std1. Once Sip5 is released, the N-terminal asparagine-rich part of Std1 aggregates, and Std1 exits the nucleus and localizes to cytoplasmic granules. SNF1 kinase is inactive in this state.


Pssm-ID: 467940  Cd Length: 200  Bit Score: 207.52  E-value: 3.11e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874  67 QVDKGGLVPQGVYTGPQDYDQHVVRQAVVDRRLAPFCKGSDDEDTYESEPFN-------------------SECPICFLY 127
Cdd:cd24139    4 TVDGGYLAPQGLYYSPLDYDKPIVRQLIIERKLAPFYKGLQDFDEDWTDEELvaavrlpsddleaqlyrnaVECPICFLY 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874 128 YPSPLNFSRCCHQPICTECFVQMKRADP-----NATNPPS------SEARSCPFCVEPDFGVTYTSPSALEAqkvgpssa 196
Cdd:cd24139   84 YPPNLNYTRCCDQPICTECFVQIKRPDPhpphdHVDPPEEdphlliSEPANCPYCAEPNFGVTYEPPAFRRT-------- 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874 197 aataaagspgsgsssgsdspndasdaanfaeraigtggaagskgsgKKKVLPVDDPAVITVDQVRPDWHVKLAQAQATIA 276
Cdd:cd24139  156 ----------------------------------------------GRQSVSATDPYVVTSDMIRPDWEAKLAAARARLA 189

                        250
                 ....*....|.
gi 630959874 277 RRANRRVIMRQ 287
Cdd:cd24139  190 RRAANATAIHA 200
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
409-601 1.46e-07

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 54.86  E-value: 1.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874 409 GSSPAPASEATASGSTANAASSGRQHGSAQAPPAPLAGTTVQSRTSPVASASTEAPVRAPPQPQVPAVSAAGLGLSPTTM 488
Cdd:PRK07003 371 GVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADGDAPVP 450

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874 489 ADLSELIEGAAPPPRTSSNARSAPNTTVTAAGSTTAVAPSGSASPAAPAGSRGS--GSPLSSPLRAPRTNLPAPEPVPVP 566
Cdd:PRK07003 451 AKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPaaVPDARAPAAASREDAPAAAAPPAP 530

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 630959874 567 QPVAGMGSAWSEAEAARNARQSLD---KQGVQVSAANG 601
Cdd:PRK07003 531 EARPPTPAAAAPAARAGGAAAALDvlrNAGMRVSSDRG 568
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 395-541 1.59e-07

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 54.61  E-value: 1.59e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874 395 AEAAKKQRAAEAQQGSSPA-PASEATASGSTANAASsgrqhGSAQAPPAPLAGTTVQSRTSPVASASTEAPVRAPPQPQV 473
Cdd:PRK07764 370 DERGLLARLERLERRLGVAgGAGAPAAAAPSAAAAA-----PAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSP 444

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 630959874 474 PAVSAAGLGLSPTTMADLSElIEGAAPPPRTSSNARSAPNTTVTAAGSTTAVAPSGSASPAAPAGSRG 541
Cdd:PRK07764 445 AGNAPAGGAPSPPPAAAPSA-QPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAAT 511
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
394-555 5.69e-07

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 52.57  E-value: 5.69e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874 394 EAEAAKKQRAAEAQQGSSPAPASEATASGSTANAASSGRQHGSAQAPPAPLAGTTVQSRTSPVASASTEAPVRAPPQPQV 473
Cdd:PRK12323 405 APAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAA 484

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874 474 PAVSAAGLGLSPTTMADLSELIEGAAPPPRTSSNARSAPNTTV-------TAAGSTTAVAPSGSASPAAPAGSRGSGSPL 546
Cdd:PRK12323 485 PAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAESIPdpatadpDDAFETLAPAPAAAPAPRAAAATEPVVAPR 564


                 ....*....
gi 630959874 547 SSPLRAPRT 555
Cdd:PRK12323 565 PPRASASGL 573
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 386-549 1.44e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 51.53  E-value: 1.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874 386 EHEEQQKREAEAAKKQRAAEAQQGSSPAPASEATASGSTANAASSGRQHGSAQAPPAPLAGTTVQSRTSPVASASTEAPV 465
Cdd:PRK07764 599 GPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAP 678

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874 466 RAPPQPQVPAVSAAGlglSPTTMADLSELIEGAAPPPRTSSNARSAPNTTVTAAGSTTAVAPSGSASPAAPAGSRGSGSP 545
Cdd:PRK07764 679 AAPPPAPAPAAPAAP---AGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAP 755


                 ....
gi 630959874 546 LSSP 549
Cdd:PRK07764 756 AQPP 759
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 411-627 2.91e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 50.55  E-value: 2.91e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874  411 SPAPASEATASGSTANAASSGRQHGSAQAPPAPLAGTTVQSRTSPVASASTEAPVRAPPQPQVPAVSAAGLGLSPTTMAD 490
Cdd:PHA03307   79 APANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGAS 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874  491 LSELiEGAAPPPRTSSNARSAPNTTVTAAGSTTAVAPSGSASPAAPAGSRGSGSPLSS------PLRAPRTNLPAPEPVP 564
Cdd:PHA03307  159 PAAV-ASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISAsasspaPAPGRSAADDAGASSS 237

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 630959874  565 VPQPVAGMGSAWSEAEAA---RNARQSLDKQGVQVSAANGSRQSSPFGSPSTSGLAGARGVNPNNP 627
Cdd:PHA03307  238 DSSSSESSGCGWGPENECplpRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSP 303
PHA03247 PHA03247
large tegument protein UL36; Provisional
 412-630 4.24e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.32  E-value: 4.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874  412 PAPASEATASGSTANAASSGRQHGSAQAPPAPLAGTTVQSRTSPVASASTEApvRAPPQPQVPAvsAAGLGLSPTTMADL 491
Cdd:PHA03247 2648 PPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLA--DPPPPPPTPE--PAPHALVSATPLPP 2723

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874  492 SELIEGAAPPPRTSSNA-RSAPNTTVTAAGSTTAVAPSGSASPAAPAGSRGSGSPlsSPLRAPRTNLPAPEPVPVPQPVA 570
Cdd:PHA03247 2724 GPAAARQASPALPAAPApPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAG--PPRRLTRPAVASLSESRESLPSP 2801

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 630959874  571 GMGSAWSEAEAARNARQSLDKQGVQVSAANGSRQ---SSPFGSPSTSGLAGARGVNPNNPFRR 630
Cdd:PHA03247 2802 WDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQptaPPPPPGPPPPSLPLGGSVAPGGDVRR 2864
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
390-553 1.02e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 48.69  E-value: 1.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874 390 QQKREAEAAKKQRAAEAQQGSSPAPASEATASGSTANAAS--SGRQHGSAQAPPAPLAGTTVQSRTSPVASASTEAPVRA 467
Cdd:PRK07003 372 VPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALApkAAAAAAATRAEAPPAAPAPPATADRGDDAADGDAPVPA 451

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874 468 PPQPQVPAVSAAGlglsPTTMADLSELIEGAAPPPRTSSNARSAPNTTVTAAGSTTAVAPSGSASPAAPAGSRGSGSPLS 547
Cdd:PRK07003 452 KANARASADSRCD----ERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAAAAP 527


                 ....*.
gi 630959874 548 SPLRAP 553
Cdd:PRK07003 528 PAPEAR 533
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
395-540 2.72e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 47.54  E-value: 2.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874 395 AEAAKKQRAAEAQQGSSPAPASEATASGSTANAASSGRQHGSAQAPPAPLAGTTVQSRTSPVASASTEAPVRAP-PQPQV 473
Cdd:PRK07003 379 AVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADGDAPVPAKaNARAS 458

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874 474 PAVSAAGLGLSPTTMADLSELIEGAAPPP-RTSSNARSAPNTTVTAAGSTTAVAPSG---------------SASPAAPA 537
Cdd:PRK07003 459 ADSRCDERDAQPPADSGSASAPASDAPPDaAFEPAPRAAAPSAATPAAVPDARAPAAasredapaaaappapEARPPTPA 538


                 ...
gi 630959874 538 GSR 540
Cdd:PRK07003 539 AAA 541
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 412-536 3.62e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 47.02  E-value: 3.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874 412 PAPASEATASGSTANAASSGRQHGSAQAPPAPLAGTTVQSRTSPVASASTEAPVRAPPQPQVPAVSAAGlglSPTTMADL 491
Cdd:PRK14951 366 PAAAAEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAP---AAAPAAAP 442

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 630959874 492 SELIEGAAPPPRTSSNARSAPNTTVTAAGSTTAVAPSGSASPAAP 536
Cdd:PRK14951 443 AAVALAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAAR 487
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 397-538 6.23e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 46.25  E-value: 6.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874 397 AAKKQRAAEAQQGSSPAPASEATAsGSTANAASSGRQHGSAQAPPAPLAgttvqsRTSPVASASTEAPVRAPPQPQVPAV 476
Cdd:PRK14951 363 AFKPAAAAEAAAPAEKKTPARPEA-AAPAAAPVAQAAAAPAPAAAPAAA------ASAPAAPPAAAPPAPVAAPAAAAPA 435

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 630959874 477 SAAGLGLSPTTMADLSELI---EGAAPPPRTssnarsAPNTTVTAAGSTTAVAPSGSASPAAPAG 538
Cdd:PRK14951 436 AAPAAAPAAVALAPAPPAQaapETVAIPVRV------APEPAVASAAPAPAAAPAAARLTPTEEG 494
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
393-547 8.64e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 45.64  E-value: 8.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874 393 REAEAAKKQRAAEAQQG-SSPAPASEATASGSTANAASSGRQHGSAQAPPAPLAGTTVQSRTSPVASASTEapvRAPPQP 471
Cdd:PRK12323 430 PEALAAARQASARGPGGaPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWE---ELPPEF 506

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 630959874 472 QVPAVSAAGLGLSPTTMADLSEliEGAAPPPRTSSNARSAPnttVTAAGSTTAVAPSGSASPAAPAGSRGSGSPLS 547
Cdd:PRK12323 507 ASPAPAQPDAAPAGWVAESIPD--PATADPDDAFETLAPAP---AAAPAPRAAAATEPVVAPRPPRASASGLPDMF 577
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 388-631 1.02e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 45.55  E-value: 1.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874  388 EEQQKREAEAAKKQRAAEAQQGSSPAPASEATASGSTANAASSGRQHGSAQAPPAPLAGTTVQ--------SRTSPVASA 459
Cdd:PHA03307  136 EMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPpaaasprpPRRSSPISA 215

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874  460 STEAPVRAPPQPQVPAVSAAGLGLSPTTMADLSELIEGAAPPPRTSSNARSAPNTTVTAAGSTTAVAPSGS--ASPAAPA 537
Cdd:PHA03307  216 SASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASssSSPRERS 295

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874  538 GSRGSGSPLSSPLRAPRTNLPAPEPVPVPQPVAGMGSAWSEAEAARNARQSLDKQGVQVSAANGSRQSSPFGSPSTSGLA 617
Cdd:PHA03307  296 PSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAP 375

                         250
                  ....*....|....
gi 630959874  618 GARGVNPNNPFRRS 631
Cdd:PHA03307  376 SSPAASAGRPTRRR 389
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 436-537 2.68e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 44.09  E-value: 2.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874 436 SAQAPPAPLAGTTVQSRTSPVASASTEAPVRAPPQPQVPAVSAAGLGLSPTTMADLSELIEGAAPPPRTSSNARSAPNTT 515
Cdd:PRK07994 367 EPEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQRAQGATKAKKSEPAAA 446

                         90       100
                 ....*....|....*....|..
gi 630959874 516 VTAAGSTTAVAPSGSASPAAPA 537
Cdd:PRK07994 447 SRARPVNSALERLASVRPAPSA 468
RING smart00184
Ring finger; E3 ubiquitin-protein ligase activity is intrinsic to the RING domain of c-Cbl and ...
 121-171 3.09e-04

Ring finger; E3 ubiquitin-protein ligase activity is intrinsic to the RING domain of c-Cbl and is likely to be a general function of this domain; Various RING fingers exhibit binding activity towards E2 ubiquitin-conjugating enzymes (Ubc' s)


Pssm-ID: 214546 [Multi-domain]  Cd Length: 40  Bit Score: 38.64  E-value: 3.09e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 630959874   121 CPICFLYYPSPLNFSRCCHQpICTECFVQMKRadpnatnppsSEARSCPFC 171
Cdd:smart00184   1 CPICLEEYLKDPVILPCGHT-FCRSCIRKWLE----------SGNNTCPIC 40
PRK10856 PRK10856
cytoskeleton protein RodZ;
387-539 3.47e-04

cytoskeleton protein RodZ;


Pssm-ID: 236776 [Multi-domain]  Cd Length: 331  Bit Score: 43.09  E-value: 3.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874 387 HEEQQKREAEAAKKQRAAEAQQGSSPAPASEATASgstanaassgrQHGSAQAPPAPLAGTTVQSRTSPVASASTeapvr 466
Cdd:PRK10856 136 HKAQQEEITTMADQSSAELSQNSGQSVPLDTSTTT-----------DPATTPAPAAPVDTTPTNSQTPAVATAPA----- 199

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 630959874 467 APPQPQVPAVsaaglglspttmadlseliegaAPPPRTSSNARSAPNTTVTAAGSTTAVAPSGSASPAAPAGS 539
Cdd:PRK10856 200 PAVDPQQNAV----------------------VAPSQANVDTAATPAPAAPATPDGAAPLPTDQAGVSTPAAD 250
PHA03247 PHA03247
large tegument protein UL36; Provisional
 395-555 3.96e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 3.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874  395 AEAAKKQRAAEAQQGSSPAPASEATASGSTANAASSGRQHGSAQAPPAPLAGTTVQSRTS-PVASASTEAPVRAP-PQPQ 472
Cdd:PHA03247 2738 APAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESlPSPWDPADPPAAVLaPAAA 2817

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874  473 VPAVSAAGLGLSPTTMAdlselIEGAAPPPRTSSNARSAPNTTVTAAGSTTAVAPSGSASPAAPAGSRGSGSPLSSPLRA 552
Cdd:PHA03247 2818 LPPAASPAGPLPPPTSA-----QPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVS 2892


                  ...
gi 630959874  553 PRT 555
Cdd:PHA03247 2893 RST 2895
RING-HC_RNF183-like cd16556
RING finger, HC subclass, found in RING finger protein RNF183, RNF223, RNF225 and similar ...
 120-174 5.21e-04

RING finger, HC subclass, found in RING finger protein RNF183, RNF223, RNF225 and similar proteins; RNF183 is an E3 ubiquitin-protein ligase that is upregulated during intestinal inflammation and is negatively regulated by miR-7. It promotes intestinal inflammation by increasing the ubiquitination and degradation of inhibitor of kappa B, thereby resulting in secondary activation of the Nuclear factor-kappaB (NF-kB) pathway. The interaction between RNF183-mediated ubiquitination and miRNA may be an important novel epigenetic mechanism in the pathogenesis of inflammatory bowel disease (IBD). The biological function of RNF223 and RNF225 remains unclear. Members of this family contain an N-terminal C3HC4-type RING-HC finger.


Pssm-ID: 438218 [Multi-domain]  Cd Length: 57  Bit Score: 38.50  E-value: 5.21e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 630959874 120 ECPICFLYY------PSPLNfsrCCHQpICTECFVQMkradpNATNPPSSEARSCPFCVEP 174
Cdd:cd16556    2 ECSICFSSYdntfktPKLLD---CGHT-FCLECLARL-----SLASPPQAERVPCPLCRQP 53
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
395-590 5.37e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.94  E-value: 5.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874 395 AEAAKKQRAAEAQQGSSPAPASEATASGSTANAASSGRQHGSAQAPPAP-LAGTTVQSRTSPVASASTEAPVRAPPQPQV 473
Cdd:PRK12323 380 APVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPaPEALAAARQASARGPGGAPAPAPAPAAAPA 459

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874 474 PAVSAAGLGLSPTTMADlseliegAAPPPRTSSNARSAPNTTVT-----AAGSTTAVAPSGSASPAAPAGSRGSGSPLSS 548
Cdd:PRK12323 460 AAARPAAAGPRPVAAAA-------AAAPARAAPAAAPAPADDDPppweeLPPEFASPAPAQPDAAPAGWVAESIPDPATA 532

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 630959874 549 PLRAPRTNLPAPEPVPVPQPVAGMGSAWSEAEAARNARQSLD 590
Cdd:PRK12323 533 DPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLP 574
PHA03247 PHA03247
large tegument protein UL36; Provisional
 397-554 7.11e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.00  E-value: 7.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874  397 AAKKQRAAEAQQGSSPAPASEATASGSTANAASSGRQHGSAQAP-PAPLAG--TTVQSRTSPVASASTEAPVRAPPQPQV 473
Cdd:PHA03247 2724 GPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPaPAPPAApaAGPPRRLTRPAVASLSESRESLPSPWD 2803

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874  474 PAVSAAGLgLSPTTMADLSELIEGAAPPPRTSSNARSAPnttvTAAGSTTAVAPSGSASPAAPAGSRG-SGSPLSSPLRA 552
Cdd:PHA03247 2804 PADPPAAV-LAPAAALPPAASPAGPLPPPTSAQPTAPPP----PPGPPPPSLPLGGSVAPGGDVRRRPpSRSPAAKPAAP 2878


                  ..
gi 630959874  553 PR 554
Cdd:PHA03247 2879 AR 2880
RING-HC cd16449
HC subclass of RING (RING-HC) finger and its variants; The RING finger is a specialized type ...
 120-171 8.33e-04

HC subclass of RING (RING-HC) finger and its variants; The RING finger is a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc. It is defined by the "cross-brace" motif that chelates zinc atoms by eight amino acid residues, typically Cys or His, arranged in a characteristic spacing. Canonical RING motifs have been categorized into two major subclasses, RING-HC (C3HC4-type) and RING-H2 (C3H2C3-type), according to their Cys/His content. There are also many variants of RING fingers. Some have a different Cys/His pattern. Some lack a single Cys or His residue at typical Zn ligand positions, especially, the fourth or eighth zinc ligand is prevalently exchanged for an Asp, which can chelate Zn in a RING finger as well. This family corresponds to the HC subclass of RING (RING-HC) fingers that are characterized by containing C3HC4-type canonical RING-HC fingers or noncanonical RING-HC finger variants, including C4C4-, C3HC3D-, C2H2C4-, and C3HC5-type modified RING-HC fingers. The canonical RING-HC finger has been defined as C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C. It binds two Zn ions in a unique "cross-brace" arrangement, which distinguishes it from tandem zinc fingers and other similar motifs. RING-HC fingers can be found in a group of diverse proteins with a variety of cellular functions, including oncogenesis, development, viral replication, signal transduction, the cell cycle, and apoptosis. Many of them are ubiquitin-protein ligases (E3s) that serve as scaffolds for binding to ubiquitin-conjugating enzymes (E2s, also referred to as ubiquitin carrier proteins or UBCs) in close proximity to substrate proteins, which enables efficient transfer of ubiquitin from E2 to the substrates.


Pssm-ID: 438113 [Multi-domain]  Cd Length: 41  Bit Score: 37.47  E-value: 8.33e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 630959874 120 ECPICFLYYPSPLnFSRCCHQpICTECFVQMKRADPNatnppssearSCPFC 171
Cdd:cd16449    2 ECPICLERLKDPV-LLPCGHV-FCRECIRRLLESGSI----------KCPIC 41
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 405-617 9.30e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.28  E-value: 9.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874 405 EAQQGSSPAPASEATASGST-ANAASSGRQHGSAQAPPAPLAGTTVQSRTSPVASASTEAPVRAPPQPQVPAVSAAGLGL 483
Cdd:PRK07764 585 EAVVGPAPGAAGGEGPPAPAsSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASD 664

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874 484 SPTTMADLSELIEGAAPPPRTSSNARSAPNTTVTAAGS-----TTAVAPSGSASPAAPAGSRGSGSPLSSPLRA----PR 554
Cdd:PRK07764 665 GGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPApapaaTPPAGQADDPAAQPPQAAQGASAPSPAADDPvplpPE 744

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 630959874 555 TNLPAPEPVPVPQPVAGMGSAWSEAEAARNARQSLDKQGVQVSAANGSRQSSPFGSPSTSGLA 617
Cdd:PRK07764 745 PDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAEDDAPSMDDEDRRDAEEVAME 807
PRK08691 PRK08691
DNA polymerase III subunits gamma and tau; Validated
 383-537 1.15e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236333 [Multi-domain]  Cd Length: 709  Bit Score: 42.00  E-value: 1.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874 383 SLVEHEEQQKREAEAAKKQRAAEAQQgssPAPASE-ATASGSTANAASsgrqhgsaqappAPLAGTTVQSrtspvasAST 461
Cdd:PRK08691 370 AVIENTELQSPSAQTAEKETAAKKPQ---PRPEAEtAQTPVQTASAAA------------MPSEGKTAGP-------VSN 427

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 630959874 462 EAPVRAPPQPQVPAVSAAGLGLSPTTMADLSELIEGAAPPPRTSSNARSAPNTTVTAAGSTTAVAPSGSASPAAPA 537
Cdd:PRK08691 428 QENNDVPPWEDAPDEAQTAAGTAQTSAKSIQTASEAETPPENQVSKNKAADNETDAPLSEVPSENPIQATPNDEAV 503
PRK13108 PRK13108
prolipoprotein diacylglyceryl transferase; Reviewed
 386-544 1.17e-03

prolipoprotein diacylglyceryl transferase; Reviewed


Pssm-ID: 237284 [Multi-domain]  Cd Length: 460  Bit Score: 41.89  E-value: 1.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874 386 EHEEQQKREAEAAKKQRAAEAQQGSSPAPASEATASGSTANAASSGRQHGSAQAPPAPLAGTTVQSRTSPVASASTEAP- 464
Cdd:PRK13108 289 EYVVDEALEREPAELAAAAVASAASAVGPVGPGEPNQPDDVAEAVKAEVAEVTDEVAAESVVQVADRDGESTPAVEETSe 368

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874 465 ---VRAPP------QPQVPAVSAAGLGLSPTTMADLseliegaaPPPRTSSNARSAPNTTVTAAGSTTAVAPSGSASPAA 535
Cdd:PRK13108 369 adiEREQPgdlagqAPAAHQVDAEAASAAPEEPAAL--------ASEAHDETEPEVPEKAAPIPDPAKPDELAVAGPGDD 440


                 ....*....
gi 630959874 536 PAGSRGSGS 544
Cdd:PRK13108 441 PAEPDGIRR 449
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
396-515 1.17e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 42.07  E-value: 1.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874 396 EAAKKQRAAEAQQGSSPA---PASEATASGSTANAASSGRQHGSAQ---APPAPLAGTTVQSRTSPVASASTEAPVRAPP 469
Cdd:PRK14971 365 KGDDASGGRGPKQHIKPVftqPAAAPQPSAAAAASPSPSQSSAAAQpsaPQSATQPAGTPPTVSVDPPAAVPVNPPSTAP 444

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 630959874 470 QPQVPAVSAAGLGLSPTTMADLSELIEGAAPPP--RTSSNARSAPNTT 515
Cdd:PRK14971 445 QAVRPAQFKEEKKIPVSKVSSLGPSTLRPIQEKaeQATGNIKEAPTGT 492
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
433-554 1.19e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.17  E-value: 1.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874 433 QHGSAQAPPAPLAGTTVQSRTSPVA-SASTEAPVRAPPQPQVPAVSAAGLGLSPTTMADLSELIEGAAPPPRTSSNAR-S 510
Cdd:PRK12323 367 QSGGGAGPATAAAAPVAQPAPAAAApAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPgG 446

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 630959874 511 APNTTVTAAGSTTAVAPSGSASPAAPAGSRGSGSPLSSPLRAPR 554
Cdd:PRK12323 447 APAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPA 490
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
407-620 1.24e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.79  E-value: 1.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874 407 QQGSSPAPASEATASGSTANAASSgRQHGSAQAPPAPLAGTTVQSRTSPVASASTEAPVRAPPQPQVPAVSAAGLGLSPt 486
Cdd:PRK12323 367 QSGGGAGPATAAAAPVAQPAPAAA-APAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGP- 444

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874 487 tmadlselieGAAPPPRTSSNARSAPNTTVTAAGSTTAVAPSGSASP-AAPAGSRGSGSPLSSPLRAPRTNLPAPEPVPV 565
Cdd:PRK12323 445 ----------GGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPArAAPAAAPAPADDDPPPWEELPPEFASPAPAQP 514

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 630959874 566 PQPVAGMGSAWSEAEAARN---ARQSLDKQGVQVSAANGSRQSSPFGSPSTSGLAGAR 620
Cdd:PRK12323 515 DAAPAGWVAESIPDPATADpddAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASG 572
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 388-539 1.40e-03

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 41.47  E-value: 1.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874 388 EEQQKREAEAAKKQRAAEAQQGSSPAPASEATASGSTANAASSGRQHGSAQAPPAPLAGTTVQSRTSPVASASTEAPVRA 467
Cdd:PTZ00436 176 QELRKREKDRERARREDAAAAAAAKQKAAAKKAAAPSGKKSAKAAAPAKAAAAPAKAAAPPAKAAAAPAKAAAAPAKAAA 255

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 630959874 468 PPQPQV--PAVSAAGLGLSPTTMADLSELIEGAAPPPRTSSNA---RSAPNTTVTAAGSTTAVAPSGSASPAAPAGS 539
Cdd:PTZ00436 256 PPAKAAapPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAApakAAAAPAKAAAAPAKAAAPPAKAAAPPAKAAT 332
PLN03237 PLN03237
DNA topoisomerase 2; Provisional
 391-556 1.48e-03

DNA topoisomerase 2; Provisional


Pssm-ID: 215641 [Multi-domain]  Cd Length: 1465  Bit Score: 41.77  E-value: 1.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874  391 QKREAEAAK------------KQRAAEAQQGSSPAPASEATASGSTANAASSGRQHGSAQAPPAPL-------------- 444
Cdd:PLN03237 1246 AKKKAPAAAkekeeedeildlKDRLAAYNLDSAPAQSAKMEETVKAVPARRAAARKKPLASVSVISdsddddddfavevs 1325

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874  445 AGTTVQSRTSPVASASTEAPVRAPPQPQVPAV-SAAGLGLSPTTMADLSEliEGAAPPPRTSSNARSAP---NTTVTAAG 520
Cdd:PLN03237 1326 LAERLKKKGGRKPAAANKKAAKPPAAAKKRGPaTVQSGQKLLTEMLKPAE--AIGISPEKKVRKMRASPfnkKSGSVLGR 1403

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 630959874  521 STTAVAPSGSASPAAPAGSRGSGSPLSSPLRAPRTN 556
Cdd:PLN03237 1404 AATNKETESSENVSGSSSSEKDEIDVSAKPRPQRAN 1439
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 386-543 1.87e-03

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 41.09  E-value: 1.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874 386 EHEEQQKREAEAAKKQRAAeAQQGSSPAPASEATASGSTANAASSGRQHGS---AQAPPAPLAGTTVQSRTSPVASASTE 462
Cdd:PTZ00436 186 ERARREDAAAAAAAKQKAA-AKKAAAPSGKKSAKAAAPAKAAAAPAKAAAPpakAAAAPAKAAAAPAKAAAPPAKAAAPP 264

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874 463 APVRAPPQPQV--PAVSAAGLGLSPTTMADLSELIEGAAPPPRTSSNA---RSAPNTTVTAAGSTTAVAPSGSASPAAPA 537
Cdd:PTZ00436 265 AKAAAPPAKAAapPAKAAAPPAKAAAPPAKAAAAPAKAAAAPAKAAAApakAAAPPAKAAAPPAKAATPPAKAAAPPAKA 344


                 ....*.
gi 630959874 538 GSRGSG 543
Cdd:PTZ00436 345 AAAPVG 350
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 411-499 2.36e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 41.03  E-value: 2.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874  411 SPAPASEATASGSTANAASSGRQHGSAQAPPAPLAGTTVQSRTSPVASASTEAPVRAPPQPqVPAVSAAGLGLSPTTMAD 490
Cdd:PRK12270   37 GPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPA-APPAAAAAAAPAAAAVED 115


                  ....*....
gi 630959874  491 LSELIEGAA 499
Cdd:PRK12270  116 EVTPLRGAA 124
RING-HC_RBR_RNF19 cd16629
RING finger, HC subclass, found in the family of RING finger proteins RNF19A, RNF19B and ...
 120-174 3.80e-03

RING finger, HC subclass, found in the family of RING finger proteins RNF19A, RNF19B and similar proteins; The family includes RING finger protein RNF19A and RNF19B, both of which are transmembrane (TM) domain-containing RBR-type E3 ubiquitin-protein ligases. RNF19A, also known as double ring-finger protein (Dorfin) or p38, localizes to the ubiquitylated inclusions in Parkinson's disease (PD), dementia with Lewy bodies, multiple system atrophy, and amyotrophic lateral sclerosis (ALS). It interacts with Psmc3, a protein component of the 19S regulatory cap of the 26S proteasome, and further participates in the ubiquitin-proteasome system in acrosome biogenesis, spermatid head shaping, and development of the head-tail coupling apparatus and tail. It modulates the ubiquitination and degradation of calcium-sensing receptor (CaR), which may contribute to a general mechanism for CaR quality control during biosynthesis. Moreover, RNF19A can also ubiquitylate mutant superoxide dismutase 1 (SOD1), the causative gene of familial ALS. It may associate with endoplasmic reticulum-associated degradation (ERAD) pathway, which is related to the pathogenesis of neurodegenerative disorders, such as PD or Alzheimer's disease. RNF19B, also known as IBR domain-containing protein 3 or natural killer lytic-associated molecule (NKLAM), plays a role in controlling tumor dissemination and metastasis. It is involved in the cytolytic function of natural killer (NK) cells and cytotoxic T lymphocytes (CTLs). It interacts with ubiquitin conjugates UbcH7 and UbcH8, and ubiquitinates uridine kinase like-1 (URKL-1) protein, targeting it for degradation. Moreover, RNF19B is a novel component of macrophage phagosomes and plays a role in macrophage anti-bacterial activity. It functions as a novel modulator of macrophage inducible nitric oxide synthase (iNOS) expression. Both RNF19A and RNF19B contain an RBR domain followed by three TMs. The RBR domain was previously known as RING-BetweenRING-RING domain or TRIAD [two RING fingers and a DRIL (double RING finger linked)] domain. Based on current understanding of the structural biology of RBR ligases, the nomenclature of RBR has been corrected as RING-BRcat (benign-catalytic)-Rcat (required-for-catalysis) recently. The RBR (RING1-BRcat-Rcat) domain uses an auto-inhibitory mechanism to modulate ubiquitination activity, as well as a hybrid mechanism that combines aspects from both RING and HECT E3 ligase function to facilitate the ubiquitination reaction. This model corresponds to the RING domain, a C3HC4-type RING-HC finger required for RBR-mediated ubiquitination.


Pssm-ID: 438291 [Multi-domain]  Cd Length: 56  Bit Score: 35.89  E-value: 3.80e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874 120 ECPICFLYYPsPLNFS--RCCHQPICTECFVQMKRADpnatnppSSEAR---SCPFCVEP 174
Cdd:cd16629    2 ECPLCLDDLS-PEFFPilLSCEHRSCRDCLRQYLTIE-------ISESRvniSCPECSER 53
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 403-537 3.86e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 40.23  E-value: 3.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874 403 AAEAQQGSSPAPASEATASGSTANAASSGRQHGSAQAPPAPLAGTTVQSRTSPVASASTEAPVRAPPQPQVPAVSAAglg 482
Cdd:PRK07994 368 PEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQRAQGATKAKKSEPA--- 444

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 630959874 483 lSPTTMADLSELIEGAAPPPRTSSNARSAPNTTVTAAGSTTAVAPSGSASPAAPA 537
Cdd:PRK07994 445 -AASRARPVNSALERLASVRPAPSALEKAPAKKEAYRWKATNPVEVKKEPVATPK 498
PHA03255 PHA03255
BDLF3; Provisional
 410-552 3.94e-03

BDLF3; Provisional


Pssm-ID: 165513 [Multi-domain]  Cd Length: 234  Bit Score: 39.50  E-value: 3.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874 410 SSPAPASEATASGSTANAASSgrqhgsaqapPAPLAGTTVQSRTSPVASAsteapvrappqpqvPAVSAAGLGLSPTTMA 489
Cdd:PHA03255  27 SGSSTASAGNVTGTTAVTTPS----------PSASGPSTNQSTTLTTTSA--------------PITTTAILSTNTTTVT 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 630959874 490 DLSEliegAAPPPRTSSNArSAPNTT--VTAAGSTTAVAPSGSASPAAPAGSRGSGSPLSSPLRA 552
Cdd:PHA03255  83 STGT----TVTPVPTTSNA-STINVTtkVTAQNITATEAGTGTSTGVTSNVTTRSSSTTSATTRI 142
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 409-555 5.38e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.15  E-value: 5.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630959874  409 GSSPAPASEATASGSTANAASSGRQHGSAQAPPAPLAGTTVQSRTSPVAS-ASTEAPVRAPPQPQVPAVSAAGLGLSPTT 487
Cdd:PHA03307  279 SSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSStSSSSESSRGAAVSPGPSPSRSPSPSRPPP 358

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 630959874  488 MADLSELIEGAAPPPRTSSNARSAPNTTVTAAGSTTAVAPSGSASPAAPAGSRGSGSPLSSPLRAPRT 555
Cdd:PHA03307  359 PADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRPRPSPLDAGAASGAF 426
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH