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Conserved domains on  [gi|635075225|ref|XP_008004632|]
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trophoblast glycoprotein [Chlorocebus sabaeus]

Protein Classification

LRRNT and LRR domain-containing protein( domain architecture ID 12183445)

protein containing domains LRRNT, LRR, and LRRCT

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
80-286 2.13e-15

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 77.67  E-value: 2.13e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635075225  80 NRNLTEVPTDLP--PYVRNLFLTGNQLAVLPAgAFARrppLAELAALNLSGSRLDEVRAgAFEHLPSLRQLDLSHNPLAY 157
Cdd:COG4886  122 GNQLTDLPEELAnlTNLKELDLSNNQLTDLPE-PLGN---LTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITD 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635075225 158 LSpfafsgsnASISAPSPLVELILNHivppddkrqNRsfegmVAAALVAGRALQGLHRLELASNHFLYLPrdVLAQLPSL 237
Cdd:COG4886  197 LP--------EPLGNLTNLEELDLSG---------NQ-----LTDLPEPLANLTNLETLDLSNNQLTDLP--ELGNLTNL 252

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 635075225 238 GHLDLSNNSLVSLTyvSFRNLTHLESLHLEDNALKVLHNGTLAELQGLP 286
Cdd:COG4886  253 EELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLTDLKLKELELLLGLN 299
LRRCT smart00082
Leucine rich repeat C-terminal domain;
295-346 1.68e-13

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 64.37  E-value: 1.68e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 635075225   295 NPWVCDCHMADMVTWLKQTEVVQGKDRLTCAFPEKMRNRvLLELNSADLDCD 346
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGP-LLELLHSEFKCP 51
LRRNT smart00013
Leucine rich repeat N-terminal domain;
62-96 9.48e-06

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 42.30  E-value: 9.48e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 635075225    62 QCPALCECSeaARTVKCVNRNLTEVPTDLPPYVRN 96
Cdd:smart00013   1 ACPAPCNCS--GTAVDCSGRGLTEVPLDLPPDTTL 33
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
80-286 2.13e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 77.67  E-value: 2.13e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635075225  80 NRNLTEVPTDLP--PYVRNLFLTGNQLAVLPAgAFARrppLAELAALNLSGSRLDEVRAgAFEHLPSLRQLDLSHNPLAY 157
Cdd:COG4886  122 GNQLTDLPEELAnlTNLKELDLSNNQLTDLPE-PLGN---LTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITD 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635075225 158 LSpfafsgsnASISAPSPLVELILNHivppddkrqNRsfegmVAAALVAGRALQGLHRLELASNHFLYLPrdVLAQLPSL 237
Cdd:COG4886  197 LP--------EPLGNLTNLEELDLSG---------NQ-----LTDLPEPLANLTNLETLDLSNNQLTDLP--ELGNLTNL 252

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 635075225 238 GHLDLSNNSLVSLTyvSFRNLTHLESLHLEDNALKVLHNGTLAELQGLP 286
Cdd:COG4886  253 EELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLTDLKLKELELLLGLN 299
LRRCT smart00082
Leucine rich repeat C-terminal domain;
295-346 1.68e-13

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 64.37  E-value: 1.68e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 635075225   295 NPWVCDCHMADMVTWLKQTEVVQGKDRLTCAFPEKMRNRvLLELNSADLDCD 346
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGP-LLELLHSEFKCP 51
LRR_8 pfam13855
Leucine rich repeat;
92-155 1.14e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.76  E-value: 1.14e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 635075225   92 PYVRNLFLTGNQLAVLPAGAFARRPPLAELaalNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPL 155
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVL---DLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
68-296 1.23e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.85  E-value: 1.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635075225  68 ECSEAARTVKCVNR-NLTEVPTDLPPYVRNLFLTGNQLAVLPAG-------AFARRPPLAELAA--------LNLSGSRL 131
Cdd:PRK15370 174 DCLKNNKTELRLKIlGLTTIPACIPEQITTLILDNNELKSLPENlqgniktLYANSNQLTSIPAtlpdtiqeMELSINRI 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635075225 132 DEVRagafEHLPS-LRQLDLSHNPLA-----------YLSPFAFSGSNASISAPSPLVELILnhivppddkrQNRSFEGM 199
Cdd:PRK15370 254 TELP----ERLPSaLQSLDLFHNKISclpenlpeelrYLSVYDNSIRTLPAHLPSGITHLNV----------QSNSLTAL 319

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635075225 200 VAAALVagralqGLHRLELASNHFLYLPRDVlaqLPSLGHLDLSNNSLVSLT----------YVSFRNLTHL-ESLhleD 268
Cdd:PRK15370 320 PETLPP------GLKTLEAGENALTSLPASL---PPELQVLDVSKNQITVLPetlpptittlDVSRNALTNLpENL---P 387

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 635075225 269 NALKVLH--NGTLAEL-QGLPH--------VKVFLDNNP 296
Cdd:PRK15370 388 AALQIMQasRNNLVRLpESLPHfrgegpqpTRIIVEYNP 426
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 266-346 3.12e-06

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 49.70  E-value: 3.12e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635075225   266 LEDNALKVLHNGTLAELQGLPHVKvfLDNNPWVCDCHMADMVTWLKQTEV-VQGKDRLTCAFPEKMRNRVLLELNSADLD 344
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEID--LSGNPFECDCGLARLPRWAEEKGVkVRQPEAALCAGPGALAGQPLLGIPLLDSG 79


                   ..
gi 635075225   345 CD 346
Cdd:TIGR00864   80 CD 81
LRRNT smart00013
Leucine rich repeat N-terminal domain;
62-96 9.48e-06

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 42.30  E-value: 9.48e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 635075225    62 QCPALCECSeaARTVKCVNRNLTEVPTDLPPYVRN 96
Cdd:smart00013   1 ACPAPCNCS--GTAVDCSGRGLTEVPLDLPPDTTL 33
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 76-299 5.62e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.01  E-value: 5.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635075225  76 VKCVNRNLTEVPtDLPPY--VRNLFLTGNQLAVLPAGAFARRpplaeLAALNLSGSRLDevRAGAFEHLPSLRQLDLSHN 153
Cdd:cd21340    7 LYLNDKNITKID-NLSLCknLKVLYLYDNKITKIENLEFLTN-----LTHLYLQNNQIE--KIENLENLVNLKKLYLGGN 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635075225 154 playlspfafsgsnaSIS------APSPLVEL-ILNHIVPPDDKrqnrsfegmvaaalvagralqglhrlelasnhFLYL 226
Cdd:cd21340   79 ---------------RISvvegleNLTNLEELhIENQRLPPGEK--------------------------------LTFD 111

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 635075225 227 PRDVLAQLPSLGHLDLSNNSLVSLTyvSFRNLTHLESLHLEDNALKVLHNgTLAELQGLPHVK-VFLDNNPwVC 299
Cdd:cd21340  112 PRSLAALSNSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEE-LLDLLSSWPSLReLDLTGNP-VC 181
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 62-91 3.88e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 37.61  E-value: 3.88e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 635075225   62 QCPALCECSeaARTVKCVNRNLTEVPTDLP 91
Cdd:pfam01462   1 ACPVPCHCS--ATVVNCSDRGLTAVPRDLP 28
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
80-286 2.13e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 77.67  E-value: 2.13e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635075225  80 NRNLTEVPTDLP--PYVRNLFLTGNQLAVLPAgAFARrppLAELAALNLSGSRLDEVRAgAFEHLPSLRQLDLSHNPLAY 157
Cdd:COG4886  122 GNQLTDLPEELAnlTNLKELDLSNNQLTDLPE-PLGN---LTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITD 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635075225 158 LSpfafsgsnASISAPSPLVELILNHivppddkrqNRsfegmVAAALVAGRALQGLHRLELASNHFLYLPrdVLAQLPSL 237
Cdd:COG4886  197 LP--------EPLGNLTNLEELDLSG---------NQ-----LTDLPEPLANLTNLETLDLSNNQLTDLP--ELGNLTNL 252

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 635075225 238 GHLDLSNNSLVSLTyvSFRNLTHLESLHLEDNALKVLHNGTLAELQGLP 286
Cdd:COG4886  253 EELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLTDLKLKELELLLGLN 299
LRRCT smart00082
Leucine rich repeat C-terminal domain;
295-346 1.68e-13

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 64.37  E-value: 1.68e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 635075225   295 NPWVCDCHMADMVTWLKQTEVVQGKDRLTCAFPEKMRNRvLLELNSADLDCD 346
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGP-LLELLHSEFKCP 51
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
95-295 1.40e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.81  E-value: 1.40e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635075225  95 RNLFLTGNQLAVLPAgAFARrppLAELAALNLSGSRLDEVRAgAFEHLPSLRQLDLSHNPLAYLspfafsgsnasisaPS 174
Cdd:COG4886  116 ESLDLSGNQLTDLPE-ELAN---LTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL--------------PE 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635075225 175 PLvelilnhivppddkrqnrsfegmvaaalvagRALQGLHRLELASNHFLYLPrDVLAQLPSLGHLDLSNNSLVSLTyVS 254
Cdd:COG4886  177 EL-------------------------------GNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLP-EP 223

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 635075225 255 FRNLTHLESLHLEDNALKvlhngTLAELQGLPHVKVF-LDNN 295
Cdd:COG4886  224 LANLTNLETLDLSNNQLT-----DLPELGNLTNLEELdLSNN 260
LRR_8 pfam13855
Leucine rich repeat;
92-155 1.14e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.76  E-value: 1.14e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 635075225   92 PYVRNLFLTGNQLAVLPAGAFARRPPLAELaalNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPL 155
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVL---DLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
211-271 2.19e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.30  E-value: 2.19e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 635075225  211 QGLHRLELASNHFLYLPRDVLAQLPSLGHLDLSNNSLVSLTYVSFRNLTHLESLHLEDNAL 271
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
80-295 1.65e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.10  E-value: 1.65e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635075225  80 NRNLTEVPTDLPPYVRNLFLTGNQLAVLPAGAFARRPPLAELAALNLSGSRldevragAFEHLPSLRQLDLSHNPLAYLs 159
Cdd:COG4886   57 LRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDL- 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635075225 160 PFAFSGsnasisapsplvelilnhivppddkrqnrsfegmvaaalvagraLQGLHRLELASNHFLYLPrDVLAQLPSLGH 239
Cdd:COG4886  129 PEELAN--------------------------------------------LTNLKELDLSNNQLTDLP-EPLGNLTNLKS 163

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 635075225 240 LDLSNNSLVSLTyVSFRNLTHLESLHLEDNALKVLHNgTLAELQGLphVKVFLDNN 295
Cdd:COG4886  164 LDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLPE-PLGNLTNL--EELDLSGN 215
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
210-296 1.02e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.78  E-value: 1.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635075225 210 LQGLHRLELASNHFLYLPRDvLAQLPSLGHLDLSNNSLVSLTyVSFRNLTHLESLHLEDNALKVLHngtlAELQGLPHVK 289
Cdd:COG4886  112 LTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLP----EELGNLTNLK 185


                 ....*...
gi 635075225 290 VF-LDNNP 296
Cdd:COG4886  186 ELdLSNNQ 193
LRR_8 pfam13855
Leucine rich repeat;
120-183 3.89e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.75  E-value: 3.89e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 635075225  120 ELAALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLAYLSPFAFSGSNAsisapspLVELILNH 183
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPS-------LRYLDLSG 58
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
68-296 1.23e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.85  E-value: 1.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635075225  68 ECSEAARTVKCVNR-NLTEVPTDLPPYVRNLFLTGNQLAVLPAG-------AFARRPPLAELAA--------LNLSGSRL 131
Cdd:PRK15370 174 DCLKNNKTELRLKIlGLTTIPACIPEQITTLILDNNELKSLPENlqgniktLYANSNQLTSIPAtlpdtiqeMELSINRI 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635075225 132 DEVRagafEHLPS-LRQLDLSHNPLA-----------YLSPFAFSGSNASISAPSPLVELILnhivppddkrQNRSFEGM 199
Cdd:PRK15370 254 TELP----ERLPSaLQSLDLFHNKISclpenlpeelrYLSVYDNSIRTLPAHLPSGITHLNV----------QSNSLTAL 319

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635075225 200 VAAALVagralqGLHRLELASNHFLYLPRDVlaqLPSLGHLDLSNNSLVSLT----------YVSFRNLTHL-ESLhleD 268
Cdd:PRK15370 320 PETLPP------GLKTLEAGENALTSLPASL---PPELQVLDVSKNQITVLPetlpptittlDVSRNALTNLpENL---P 387

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 635075225 269 NALKVLH--NGTLAEL-QGLPH--------VKVFLDNNP 296
Cdd:PRK15370 388 AALQIMQasRNNLVRLpESLPHfrgegpqpTRIIVEYNP 426
LRR_8 pfam13855
Leucine rich repeat;
235-296 1.68e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.82  E-value: 1.68e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 635075225  235 PSLGHLDLSNNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTlaeLQGLPHVKV-FLDNNP 296
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGA---FSGLPSLRYlDLSGNR 60
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 266-346 3.12e-06

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 49.70  E-value: 3.12e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635075225   266 LEDNALKVLHNGTLAELQGLPHVKvfLDNNPWVCDCHMADMVTWLKQTEV-VQGKDRLTCAFPEKMRNRVLLELNSADLD 344
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEID--LSGNPFECDCGLARLPRWAEEKGVkVRQPEAALCAGPGALAGQPLLGIPLLDSG 79


                   ..
gi 635075225   345 CD 346
Cdd:TIGR00864   80 CD 81
LRRNT smart00013
Leucine rich repeat N-terminal domain;
62-96 9.48e-06

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 42.30  E-value: 9.48e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 635075225    62 QCPALCECSeaARTVKCVNRNLTEVPTDLPPYVRN 96
Cdd:smart00013   1 ACPAPCNCS--GTAVDCSGRGLTEVPLDLPPDTTL 33
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 76-299 5.62e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.01  E-value: 5.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635075225  76 VKCVNRNLTEVPtDLPPY--VRNLFLTGNQLAVLPAGAFARRpplaeLAALNLSGSRLDevRAGAFEHLPSLRQLDLSHN 153
Cdd:cd21340    7 LYLNDKNITKID-NLSLCknLKVLYLYDNKITKIENLEFLTN-----LTHLYLQNNQIE--KIENLENLVNLKKLYLGGN 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635075225 154 playlspfafsgsnaSIS------APSPLVEL-ILNHIVPPDDKrqnrsfegmvaaalvagralqglhrlelasnhFLYL 226
Cdd:cd21340   79 ---------------RISvvegleNLTNLEELhIENQRLPPGEK--------------------------------LTFD 111

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 635075225 227 PRDVLAQLPSLGHLDLSNNSLVSLTyvSFRNLTHLESLHLEDNALKVLHNgTLAELQGLPHVK-VFLDNNPwVC 299
Cdd:cd21340  112 PRSLAALSNSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEE-LLDLLSSWPSLReLDLTGNP-VC 181
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 62-91 3.88e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 37.61  E-value: 3.88e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 635075225   62 QCPALCECSeaARTVKCVNRNLTEVPTDLP 91
Cdd:pfam01462   1 ACPVPCHCS--ATVVNCSDRGLTAVPRDLP 28
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 121-271 1.54e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.99  E-value: 1.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635075225 121 LAALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLAYLSPFAFSGSNASIsapsplveLILNhivppddkRQNRSFEGMv 200
Cdd:PLN00113  71 VVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGPIPDDIFTTSSSL--------RYLN--------LSNNNFTGS- 133

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 635075225 201 aaalVAGRALQGLHRLELASNHFL-YLPRDVlAQLPSLGHLDLSNNSLVSLTYVSFRNLTHLESLHLEDNAL 271
Cdd:PLN00113 134 ----IPRGSIPNLETLDLSNNMLSgEIPNDI-GSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQL 200
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 235-269 4.06e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.91  E-value: 4.06e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 635075225  235 PSLGHLDLSNNSLVSLTyvSFRNLTHLESLHLEDN 269
Cdd:pfam12799   1 PNLEVLDLSNNQITDIP--PLAKLPNLETLDLSGN 33
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
82-190 6.55e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 38.76  E-value: 6.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635075225  82 NLTEVPTDLP--PYVRNLFLTGNQLAVLPAgaFARrppLAELAALNLSGSRLDEVRAGAfeHLPSLRQLDLSHNPLAYLS 159
Cdd:COG4886  216 QLTDLPEPLAnlTNLETLDLSNNQLTDLPE--LGN---LTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLK 288

                         90       100       110
                 ....*....|....*....|....*....|.
gi 635075225 160 PFAFSGSNASISAPSPLVELILNHIVPPDDK 190
Cdd:COG4886  289 LKELELLLGLNSLLLLLLLLNLLELLILLLL 319
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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