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Conserved domains on  [gi|672053701|ref|XP_008762241|]
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R-spondin-1 isoform X1 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Furin-like_2 pfam15913
Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a ...
 42-142 7.88e-52

Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a variety of proteins from eukaryotes that are involved in the mechanism of signal transduction by receptor tyrosine kinases, which involves receptor aggregation.


:

Pssm-ID: 464939 [Multi-domain]  Cd Length: 102  Bit Score: 164.14  E-value: 7.88e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672053701   42 KGCELCSEVNGCLKCSPKLFILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKCKIEHCEACFSHNFCTKCQEGLYLH 121
Cdd:pfam15913   2 SGCVLCSEENGCLTCQPRLFLLLERNGIRQYGVCLHSCPPGYFGIRGQEVNRCTKCKAENCESCFSKDFCTKCKEGFYLH 81

                          90       100
                  ....*....|....*....|.
gi 672053701  122 KGRCYPACPEGSTAANSTMEC 142
Cdd:pfam15913  82 KGKCLDTCPEGTAAQNSTMEC 102
TSP1_spondin super family cl46269
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 148-203 1.84e-07

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


The actual alignment was detected with superfamily member pfam19028:

Pssm-ID: 480609  Cd Length: 52  Bit Score: 46.89  E-value: 1.84e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 672053701  148 CEMSEWSPWGPCSKKrklCGfrKGSEERTRRVLHAPGGDQTNCSDTKETRKCTVRR 203
Cdd:pfam19028   1 CVVSEWSEWSECSVT---CG--GGVQTRTRTVIVEPQNGGRPCPELLERRPCNLPP 51
 
Name Accession Description Interval E-value
Furin-like_2 pfam15913
Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a ...
 42-142 7.88e-52

Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a variety of proteins from eukaryotes that are involved in the mechanism of signal transduction by receptor tyrosine kinases, which involves receptor aggregation.


Pssm-ID: 464939 [Multi-domain]  Cd Length: 102  Bit Score: 164.14  E-value: 7.88e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672053701   42 KGCELCSEVNGCLKCSPKLFILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKCKIEHCEACFSHNFCTKCQEGLYLH 121
Cdd:pfam15913   2 SGCVLCSEENGCLTCQPRLFLLLERNGIRQYGVCLHSCPPGYFGIRGQEVNRCTKCKAENCESCFSKDFCTKCKEGFYLH 81

                          90       100
                  ....*....|....*....|.
gi 672053701  122 KGRCYPACPEGSTAANSTMEC 142
Cdd:pfam15913  82 KGKCLDTCPEGTAAQNSTMEC 102
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 148-203 1.84e-07

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 46.89  E-value: 1.84e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 672053701  148 CEMSEWSPWGPCSKKrklCGfrKGSEERTRRVLHAPGGDQTNCSDTKETRKCTVRR 203
Cdd:pfam19028   1 CVVSEWSEWSECSVT---CG--GGVQTRTRTVIVEPQNGGRPCPELLERRPCNLPP 51
FU cd00064
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ...
 100-142 5.22e-04

Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.


Pssm-ID: 238021 [Multi-domain]  Cd Length: 49  Bit Score: 37.11  E-value: 5.22e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 672053701 100 EHCEACFSH--NFCTKCQEGLYLHKGRCYPACPEGSTAANSTMEC 142
Cdd:cd00064    4 PSCATCTGPgpDQCTSCRHGFYLDGGTCVSECPEGTYADTEGGVC 48
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 153-207 2.22e-03

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 39.18  E-value: 2.22e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 672053701 153 WSPWGPCSKKrklCGfrKGSEERTRRVLHApgGDQTNCSDTKETRKCTVRRTPCP 207
Cdd:PTZ00441 243 WDEWTPCSVT---CG--KGTHSRSRPILHE--GCTTHMVEECEEEECPVEPEPLP 290
 
Name Accession Description Interval E-value
Furin-like_2 pfam15913
Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a ...
 42-142 7.88e-52

Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a variety of proteins from eukaryotes that are involved in the mechanism of signal transduction by receptor tyrosine kinases, which involves receptor aggregation.


Pssm-ID: 464939 [Multi-domain]  Cd Length: 102  Bit Score: 164.14  E-value: 7.88e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672053701   42 KGCELCSEVNGCLKCSPKLFILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKCKIEHCEACFSHNFCTKCQEGLYLH 121
Cdd:pfam15913   2 SGCVLCSEENGCLTCQPRLFLLLERNGIRQYGVCLHSCPPGYFGIRGQEVNRCTKCKAENCESCFSKDFCTKCKEGFYLH 81

                          90       100
                  ....*....|....*....|.
gi 672053701  122 KGRCYPACPEGSTAANSTMEC 142
Cdd:pfam15913  82 KGKCLDTCPEGTAAQNSTMEC 102
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 148-203 1.84e-07

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 46.89  E-value: 1.84e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 672053701  148 CEMSEWSPWGPCSKKrklCGfrKGSEERTRRVLHAPGGDQTNCSDTKETRKCTVRR 203
Cdd:pfam19028   1 CVVSEWSEWSECSVT---CG--GGVQTRTRTVIVEPQNGGRPCPELLERRPCNLPP 51
FU cd00064
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ...
 100-142 5.22e-04

Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.


Pssm-ID: 238021 [Multi-domain]  Cd Length: 49  Bit Score: 37.11  E-value: 5.22e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 672053701 100 EHCEACFSH--NFCTKCQEGLYLHKGRCYPACPEGSTAANSTMEC 142
Cdd:cd00064    4 PSCATCTGPgpDQCTSCRHGFYLDGGTCVSECPEGTYADTEGGVC 48
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 153-207 2.22e-03

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 39.18  E-value: 2.22e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 672053701 153 WSPWGPCSKKrklCGfrKGSEERTRRVLHApgGDQTNCSDTKETRKCTVRRTPCP 207
Cdd:PTZ00441 243 WDEWTPCSVT---CG--KGTHSRSRPILHE--GCTTHMVEECEEEECPVEPEPLP 290
PTZ00087 PTZ00087
thrombosponding-related protein; Provisional
 151-216 5.60e-03

thrombosponding-related protein; Provisional


Pssm-ID: 185438  Cd Length: 340  Bit Score: 37.62  E-value: 5.60e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672053701 151 SEWSPWGPCSKKrklCGFRKGSEERTRRVLHAPGgdqtNC--SDTKETRKCTVRRTPCPEGQKRKKAS 216
Cdd:PTZ00087 234 TEWGEWSNCSME---CDHPDNVQIRERKCAHPSG----DCfkGDLKETRPCQVPLPPCNSLFEHKESS 294
TSP_1 pfam00090
Thrombospondin type 1 domain;
151-202 6.22e-03

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 33.93  E-value: 6.22e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 672053701  151 SEWSPWGPCSkkrKLCGfrKGSEERTRRVLHAPGGDQTNCSDTKETRKCTVR 202
Cdd:pfam00090   1 SPWSPWSPCS---VTCG--KGIQVRQRTCKSPFPGGEPCTGDDIETQACKMD 47
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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