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Conserved domains on  [gi|672066129|ref|XP_008765584|]
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protein phosphatase 1 regulatory subunit 7 isoform X1 [Rattus norvegicus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 97-272 6.82e-29

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 109.88  E-value: 6.82e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672066129  97 LKKVKSLCLRQNLIKCIENLDELQSLRELDLYDNQIKKIENLEALTelevldisfnllrniegidKLTQlkkLFLVNNKI 176
Cdd:cd21340    1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLT-------------------NLTH---LYLQNNQI 58

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672066129 177 NKIENISTLQQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKI---TKL----QNLDALSN-LTVLSMQSNRLTKIEGL 248
Cdd:cd21340   59 EKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEELHIENQRLppgEKLtfdpRSLAALSNsLRVLNISGNNIDSLEPL 138

                        170       180
                 ....*....|....*....|....
gi 672066129 249 QNLVNLRELYLSHNGIEVIEGLEN 272
Cdd:cd21340  139 APLRNLEQLDASNNQISDLEELLD 162
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 97-272 6.82e-29

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 109.88  E-value: 6.82e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672066129  97 LKKVKSLCLRQNLIKCIENLDELQSLRELDLYDNQIKKIENLEALTelevldisfnllrniegidKLTQlkkLFLVNNKI 176
Cdd:cd21340    1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLT-------------------NLTH---LYLQNNQI 58

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672066129 177 NKIENISTLQQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKI---TKL----QNLDALSN-LTVLSMQSNRLTKIEGL 248
Cdd:cd21340   59 EKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEELHIENQRLppgEKLtfdpRSLAALSNsLRVLNISGNNIDSLEPL 138

                        170       180
                 ....*....|....*....|....
gi 672066129 249 QNLVNLRELYLSHNGIEVIEGLEN 272
Cdd:cd21340  139 APLRNLEQLDASNNQISDLEELLD 162
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
95-272 3.24e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 98.08  E-value: 3.24e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672066129  95 EVLKKVKSLCLRQNLIKCIENLDELQSLRELDLYDNqikkiENLEALTELEVLDISFNLLRNI-EGIDKLTQLKKLFLVN 173
Cdd:COG4886   71 LLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-----EELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSN 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672066129 174 NKINKI-ENISTLQQLQMLELGSNRIRAI-ENIDTLTNLESLFLGKNKITKLQN-LDALSNLTVLSMQSNRLTKI-EGLQ 249
Cdd:COG4886  146 NQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLPEpLGNLTNLEELDLSGNQLTDLpEPLA 225

                        170       180
                 ....*....|....*....|...
gi 672066129 250 NLVNLRELYLSHNGIEVIEGLEN 272
Cdd:COG4886  226 NLTNLETLDLSNNQLTDLPELGN 248
LRR_9 pfam14580
Leucine-rich repeat;
123-244 1.91e-08

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 52.84  E-value: 1.91e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672066129  123 RELDLYDNQIKKIENLEA-LTELEVLDISFNLLRNIEGIDKLTQLKKLFLVNNKINKIEnistlqqlqmlelgsnrirai 201
Cdd:pfam14580  22 RELDLRGYKIPIIENLGAtLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIG--------------------- 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 672066129  202 ENID-TLTNLESLFLGKNKITKLQNLD---ALSNLTVLSMQSNRLTK 244
Cdd:pfam14580  81 EGLGeALPNLTELILTNNNLQELGDLDplaSLKKLTFLSLLRNPVTN 127
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 116-265 9.15e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 43.68  E-value: 9.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672066129 116 LDELQSLRELDL-YDNQIKKI-ENLEALTELEVLDISFNLLRNI--EGIDKLTQLKKLFLVNNKIN-KI-ENISTLQQLQ 189
Cdd:PLN00113 232 IGGLTSLNHLDLvYNNLTGPIpSSLGNLKNLQYLFLYQNKLSGPipPSIFSLQKLISLDLSDNSLSgEIpELVIQLQNLE 311

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672066129 190 MLELGSNRI--RAIENIDTLTNLESLFLGKNKITK--LQNLDALSNLTVLSMQSNRLT-KI-EGLQNLVNLRELYLSHNG 263
Cdd:PLN00113 312 ILHLFSNNFtgKIPVALTSLPRLQVLQLWSNKFSGeiPKNLGKHNNLTVLDLSTNNLTgEIpEGLCSSGNLFKLILFSNS 391


                 ..
gi 672066129 264 IE 265
Cdd:PLN00113 392 LE 393
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 97-272 6.82e-29

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 109.88  E-value: 6.82e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672066129  97 LKKVKSLCLRQNLIKCIENLDELQSLRELDLYDNQIKKIENLEALTelevldisfnllrniegidKLTQlkkLFLVNNKI 176
Cdd:cd21340    1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLT-------------------NLTH---LYLQNNQI 58

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672066129 177 NKIENISTLQQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKI---TKL----QNLDALSN-LTVLSMQSNRLTKIEGL 248
Cdd:cd21340   59 EKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEELHIENQRLppgEKLtfdpRSLAALSNsLRVLNISGNNIDSLEPL 138

                        170       180
                 ....*....|....*....|....
gi 672066129 249 QNLVNLRELYLSHNGIEVIEGLEN 272
Cdd:cd21340  139 APLRNLEQLDASNNQISDLEELLD 162
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 83-245 4.65e-24

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 96.78  E-value: 4.65e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672066129  83 LNHYRIGKIEGFEVLKKVKSLCLRQNLIKCIENLDELQSLRELDLYDNQIKKIENLEALTELEVLDISFNLLRNIEGIDK 162
Cdd:cd21340    9 LNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLEN 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672066129 163 LTQLKKLFLVNNKI---NKIE----NISTLQQ-LQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLD----ALS 230
Cdd:cd21340   89 LTNLEELHIENQRLppgEKLTfdprSLAALSNsLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLdllsSWP 168

                        170
                 ....*....|....*
gi 672066129 231 NLTVLSMQSNRLTKI 245
Cdd:cd21340  169 SLRELDLTGNPVCKK 183
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
95-272 3.24e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 98.08  E-value: 3.24e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672066129  95 EVLKKVKSLCLRQNLIKCIENLDELQSLRELDLYDNqikkiENLEALTELEVLDISFNLLRNI-EGIDKLTQLKKLFLVN 173
Cdd:COG4886   71 LLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-----EELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSN 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672066129 174 NKINKI-ENISTLQQLQMLELGSNRIRAI-ENIDTLTNLESLFLGKNKITKLQN-LDALSNLTVLSMQSNRLTKI-EGLQ 249
Cdd:COG4886  146 NQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLPEpLGNLTNLEELDLSGNQLTDLpEPLA 225

                        170       180
                 ....*....|....*....|...
gi 672066129 250 NLVNLRELYLSHNGIEVIEGLEN 272
Cdd:COG4886  226 NLTNLETLDLSNNQLTDLPELGN 248
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
100-267 5.63e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.50  E-value: 5.63e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672066129 100 VKSLCLRQNLIKCIENLDELQSLRELDLYDNQIKKIENLEALTELEVLDISFNLLRNIEGIDKLTQLKKLFLVNNkinki 179
Cdd:COG4886   32 LLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN----- 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672066129 180 ENISTLQQLQMLELGSNRIRAI-ENIDTLTNLESLFLGKNKITKL-QNLDALSNLTVLSMQSNRLTKI-EGLQNLVNLRE 256
Cdd:COG4886  107 EELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKE 186

                        170
                 ....*....|.
gi 672066129 257 LYLSHNGIEVI 267
Cdd:COG4886  187 LDLSNNQITDL 197
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
97-290 7.77e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 62.26  E-value: 7.77e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672066129  97 LKKVKSLCLRQNLIKCI-ENLDELQSLRELDLYDNQIKKIENLEALTELEVLDISFNLLRNIEGIDKLTQLKKLFLVNNK 175
Cdd:COG4886  204 LTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQ 283

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672066129 176 IN--KIENISTLQQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALSNLTVLSMQSNRLTKIEGLQNLVN 253
Cdd:COG4886  284 LTdlKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLL 363

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 672066129 254 LRELYLSHNGIEVIEGLENNMANTGIISSVLPIHPGH 290
Cdd:COG4886  364 TLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGV 400
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
101-267 1.91e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 61.10  E-value: 1.91e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672066129 101 KSLCLRQNLIKCIENLDELQSLRELDLYDNQIKKIENLEALTELEVLDISFNLLRNIEGIDKLTQLKKLFLVNNKINKIE 180
Cdd:COG4886   11 KLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLT 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672066129 181 NISTLQQLQMLELGSNriraiENIDTLTNLESLFLGKNKITKL-QNLDALSNLTVLSMQSNRLTKI-EGLQNLVNLRELY 258
Cdd:COG4886   91 DLGDLTNLTELDLSGN-----EELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLD 165


                 ....*....
gi 672066129 259 LSHNGIEVI 267
Cdd:COG4886  166 LSNNQLTDL 174
LRR_9 pfam14580
Leucine-rich repeat;
123-244 1.91e-08

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 52.84  E-value: 1.91e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672066129  123 RELDLYDNQIKKIENLEA-LTELEVLDISFNLLRNIEGIDKLTQLKKLFLVNNKINKIEnistlqqlqmlelgsnrirai 201
Cdd:pfam14580  22 RELDLRGYKIPIIENLGAtLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIG--------------------- 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 672066129  202 ENID-TLTNLESLFLGKNKITKLQNLD---ALSNLTVLSMQSNRLTK 244
Cdd:pfam14580  81 EGLGeALPNLTELILTNNNLQELGDLDplaSLKKLTFLSLLRNPVTN 127
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 61-282 4.40e-07

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 50.56  E-value: 4.40e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672066129  61 EEHELAVDMETISLDRDAEDVDLNHYRIGKiEGFEVLKK-------VKSLCLRQNLI------KCIENLDELQSLRELDL 127
Cdd:COG5238  165 LGLLAAISMAKALQNNSVETVYLGCNQIGD-EGIEELAEaltqnttVTTLWLKRNPIgdegaeILAEALKGNKSLTTLDL 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672066129 128 YDNQIKKiENLEALTElevldisfNLLRNiegidklTQLKKLFLVNNKINK------IENISTLQQLQMLELGSNRIRA- 200
Cdd:COG5238  244 SNNQIGD-EGVIALAE--------ALKNN-------TTVETLYLSGNQIGAegaialAKALQGNTTLTSLDLSVNRIGDe 307

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672066129 201 -----IENIDTLTNLESLFLGKNKITK------LQNLDALSNLTVLSMQSNRLTK------IEGLQNLVNLRELYLSHNG 263
Cdd:COG5238  308 gaialAEGLQGNKTLHTLNLAYNGIGAqgaialAKALQENTTLHSLDLSDNQIGDegaialAKYLEGNTTLRELNLGKNN 387

                        250       260
                 ....*....|....*....|....*
gi 672066129 264 I------EVIEGLENNMANTGIISS 282
Cdd:COG5238  388 IgkqgaeALIDALQTNRLHTLILDG 412
LRR_9 pfam14580
Leucine-rich repeat;
167-260 1.45e-06

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 47.45  E-value: 1.45e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672066129  167 KKLFLVNNKINKIENI-STLQQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKL-QNLD-ALSNLTVLSMQSNRLT 243
Cdd:pfam14580  22 RELDLRGYKIPIIENLgATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIgEGLGeALPNLTELILTNNNLQ 101

                          90
                  ....*....|....*...
gi 672066129  244 KIEGLQNLVNLREL-YLS 260
Cdd:pfam14580 102 ELGDLDPLASLKKLtFLS 119
LRR_8 pfam13855
Leucine rich repeat;
208-264 3.40e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 3.40e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672066129  208 TNLESLFLGKNKITKL--QNLDALSNLTVLSMQSNRLTKIEG--LQNLVNLRELYLSHNGI 264
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
79-260 1.60e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 45.69  E-value: 1.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672066129  79 EDVDLNHYRIGKIEGFEVLKKVKSLCLRQNLIKCIENLDELQSLRELDLYDNQIK--KIENLEALTELEVLDISFNLLRN 156
Cdd:COG4886  231 ETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTdlKLKELELLLGLNSLLLLLLLLNL 310

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672066129 157 IEGIDKLTQLKKLFLVNNKINKIENISTLQQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALSNLTVLS 236
Cdd:COG4886  311 LELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLL 390

                        170       180
                 ....*....|....*....|....
gi 672066129 237 MQSNRLTKIEGLQNLVNLRELYLS 260
Cdd:COG4886  391 LLLLTTTAGVLLLTLALLDAVNTE 414
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 120-162 2.51e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 40.69  E-value: 2.51e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 672066129  120 QSLRELDLYDNQIKKIENLEALTELEVLDISFN-LLRNIEGIDK 162
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLAN 44
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 116-265 9.15e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 43.68  E-value: 9.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672066129 116 LDELQSLRELDL-YDNQIKKI-ENLEALTELEVLDISFNLLRNI--EGIDKLTQLKKLFLVNNKIN-KI-ENISTLQQLQ 189
Cdd:PLN00113 232 IGGLTSLNHLDLvYNNLTGPIpSSLGNLKNLQYLFLYQNKLSGPipPSIFSLQKLISLDLSDNSLSgEIpELVIQLQNLE 311

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672066129 190 MLELGSNRI--RAIENIDTLTNLESLFLGKNKITK--LQNLDALSNLTVLSMQSNRLT-KI-EGLQNLVNLRELYLSHNG 263
Cdd:PLN00113 312 ILHLFSNNFtgKIPVALTSLPRLQVLQLWSNKFSGeiPKNLGKHNNLTVLDLSTNNLTgEIpEGLCSSGNLFKLILFSNS 391


                 ..
gi 672066129 264 IE 265
Cdd:PLN00113 392 LE 393
LRR_9 pfam14580
Leucine-rich repeat;
191-271 9.89e-05

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 42.06  E-value: 9.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672066129  191 LELGSNRIRAIENID-TLTNLESLFLGKNKITKLQNLDALSNLTVLSMQSNRLTKI-EGL-QNLVNLRELYLSHNGIEVI 267
Cdd:pfam14580  24 LDLRGYKIPIIENLGaTLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIgEGLgEALPNLTELILTNNNLQEL 103


                  ....
gi 672066129  268 EGLE 271
Cdd:pfam14580 104 GDLD 107
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 231-262 1.03e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.15  E-value: 1.03e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 672066129  231 NLTVLSMQSNRLTKIEGLQNLVNLRELYLSHN 262
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGN 33
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 208-250 1.75e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.38  E-value: 1.75e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 672066129  208 TNLESLFLGKNKITKLQNLDALSNLTVLSMQSN-RLTKIEGLQN 250
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLAN 44
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 142-187 1.76e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.38  E-value: 1.76e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 672066129  142 TELEVLDISFNLLRNIEGIDKLTQLKKLFLVNNkiNKIENISTLQQ 187
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGN--NKITDLSDLAN 44
LRR_8 pfam13855
Leucine rich repeat;
120-176 3.22e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 3.22e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672066129  120 QSLRELDLYDNQIKKI--ENLEALTELEVLDISFNLLRNIEG--IDKLTQLKKLFLVNNKI 176
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 229-273 5.39e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.54  E-value: 5.39e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 672066129 229 LSNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGIEVIEGLENN 273
Cdd:cd21340    1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFL 45
LRR_9 pfam14580
Leucine-rich repeat;
81-156 9.92e-04

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 39.36  E-value: 9.92e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672066129   81 VDLNHYRIGKIEGFEVLKKVKSLCLRQNLIKCI-ENLDE-LQSLRELDLYDNQIKKIENLEALTELEVLDiSFNLLRN 156
Cdd:pfam14580  47 IDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIgEGLGEaLPNLTELILTNNNLQELGDLDPLASLKKLT-FLSLLRN 123
LRR_8 pfam13855
Leucine rich repeat;
164-220 1.11e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.73  E-value: 1.11e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672066129  164 TQLKKLFLVNNKINKI--ENISTLQQLQMLELGSNRIRAIEN--IDTLTNLESLFLGKNKI 220
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 121-244 1.14e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.03  E-value: 1.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672066129 121 SLRELDLYDNQIKK------IENLEALTELEVLDISFNLLRNiEGIDKL-------TQLKKLFLVNNKINKI------EN 181
Cdd:cd00116  138 ALEKLVLGRNRLEGascealAKALRANRDLKELNLANNGIGD-AGIRALaeglkanCNLEVLDLNNNGLTDEgasalaET 216

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 672066129 182 ISTLQQLQMLELGSNRIR-------AIENIDTLTNLESLFLGKNKITKL------QNLDALSNLTVLSMQSNRLTK 244
Cdd:cd00116  217 LASLKSLEVLNLGDNNLTdagaaalASALLSPNISLLTLSLSCNDITDDgakdlaEVLAEKESLLELDLRGNKFGE 292
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 186-227 1.44e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.68  E-value: 1.44e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 672066129  186 QQLQMLELGSNRIRAIENIDTLTNLESLFL-GKNKITKLQNLD 227
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLsGNNKITDLSDLA 43
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 98-139 3.16e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.91  E-value: 3.16e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 672066129   98 KKVKSLCLRQNLIKCIENLDELQSLRELDLYDN-QIKKIENLE 139
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLA 43
LRR_8 pfam13855
Leucine rich repeat;
142-198 3.35e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.19  E-value: 3.35e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672066129  142 TELEVLDISFNLLRNIEG--IDKLTQLKKLFLVNNKINKIEN--ISTLQQLQMLELGSNRI 198
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 164-209 3.97e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.53  E-value: 3.97e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 672066129  164 TQLKKLFLVNNKINKIENISTLQQLQMLELGSNRIraIENIDTLTN 209
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNK--ITDLSDLAN 44
LRR_8 pfam13855
Leucine rich repeat;
230-269 6.55e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 34.42  E-value: 6.55e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 672066129  230 SNLTVLSMQSNRLTKIEG--LQNLVNLRELYLSHNGIEVIEG 269
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSP 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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