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Conserved domains on  [gi|672066912|ref|XP_008765804|]
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ran-binding protein 17 isoform X1 [Rattus norvegicus]

Protein Classification

exportin/importin beta family protein( domain architecture ID 10658322)

exportin/importin beta family protein such as Saccharomyces cerevisiae importin subunit beta-4 that functions in nuclear protein import as nuclear transport receptor

CATH:  1.25.10.10
Gene Ontology:  GO:0031267|GO:0006886
SCOP:  4001298

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IBN_N smart00913
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ...
 30-95 5.07e-11

Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.


:

Pssm-ID: 197981 [Multi-domain]  Cd Length: 67  Bit Score: 59.18  E-value: 5.07e-11
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 672066912     30 AEKALLELIDSPECLSKCQLLLEQGTTSYAQLLAATCLSKLVTRI-NPLPVEQRIDIRNYILNYVAS 95
Cdd:smart00913    1 AEKQLEQFQKSPGFWLLLLEILANSEDQYVRQLAAITLKNKITRRwSSLPEEEKEEIKNSLLELLLS 67
CRM1 super family cl34903
Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular ...
 8-167 9.99e-04

Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5101:

Pssm-ID: 227432 [Multi-domain]  Cd Length: 1053  Bit Score: 43.39  E-value: 9.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672066912    8 LAELEALCTHLYVGTDLNERiEAEKALLELIDSPECLSKCQLLLEQGTTSYAQLLAATCLSKLV-TRINPLPVEQRIDIR 86
Cdd:COG5101    13 IALLDKVVTTFYQGDGRKQE-QAQRILTKFQELPDAWTKADYILNNSKLPQSKYIALSLLDKLItTKWKLLPEGMRQGIR 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672066912   87 NYILNYVASQPKLAPfVIQALIQVIAKLtKLGWFEVQKDEFVFR--EIIADVKKFLQGTVEHCIIGVIILSELTQEmnLV 164
Cdd:COG5101    92 NYVVQLVIEKSQDDK-VRDKQKYVLNKL-DLTLVQILKQEWPRNwpTFIPELINVSQISMEVCENNMIVLKLLSEE--VF 167


                  ...
gi 672066912  165 DYS 167
Cdd:COG5101   168 DFS 170
 
Name Accession Description Interval E-value
IBN_N smart00913
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ...
 30-95 5.07e-11

Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.


Pssm-ID: 197981 [Multi-domain]  Cd Length: 67  Bit Score: 59.18  E-value: 5.07e-11
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 672066912     30 AEKALLELIDSPECLSKCQLLLEQGTTSYAQLLAATCLSKLVTRI-NPLPVEQRIDIRNYILNYVAS 95
Cdd:smart00913    1 AEKQLEQFQKSPGFWLLLLEILANSEDQYVRQLAAITLKNKITRRwSSLPEEEKEEIKNSLLELLLS 67
IBN_N pfam03810
Importin-beta N-terminal domain;
30-95 3.10e-10

Importin-beta N-terminal domain;


Pssm-ID: 397745 [Multi-domain]  Cd Length: 72  Bit Score: 57.25  E-value: 3.10e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 672066912    30 AEKALLELIDSPECLSKCQLLLEQGTTS-YAQLLAATCLSKLVTRI-----NPLPVEQRIDIRNYILNYVAS 95
Cdd:pfam03810    1 AEKQLEQFEKSPGFWSKLLQILSNSENPlEVRQLAALYLKNLITRHweeekNSLPPEEKEQIKNNLLNLLGS 72
CRM1 COG5101
Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular ...
 8-167 9.99e-04

Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion];


Pssm-ID: 227432 [Multi-domain]  Cd Length: 1053  Bit Score: 43.39  E-value: 9.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672066912    8 LAELEALCTHLYVGTDLNERiEAEKALLELIDSPECLSKCQLLLEQGTTSYAQLLAATCLSKLV-TRINPLPVEQRIDIR 86
Cdd:COG5101    13 IALLDKVVTTFYQGDGRKQE-QAQRILTKFQELPDAWTKADYILNNSKLPQSKYIALSLLDKLItTKWKLLPEGMRQGIR 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672066912   87 NYILNYVASQPKLAPfVIQALIQVIAKLtKLGWFEVQKDEFVFR--EIIADVKKFLQGTVEHCIIGVIILSELTQEmnLV 164
Cdd:COG5101    92 NYVVQLVIEKSQDDK-VRDKQKYVLNKL-DLTLVQILKQEWPRNwpTFIPELINVSQISMEVCENNMIVLKLLSEE--VF 167


                  ...
gi 672066912  165 DYS 167
Cdd:COG5101   168 DFS 170
 
Name Accession Description Interval E-value
IBN_N smart00913
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ...
 30-95 5.07e-11

Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.


Pssm-ID: 197981 [Multi-domain]  Cd Length: 67  Bit Score: 59.18  E-value: 5.07e-11
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 672066912     30 AEKALLELIDSPECLSKCQLLLEQGTTSYAQLLAATCLSKLVTRI-NPLPVEQRIDIRNYILNYVAS 95
Cdd:smart00913    1 AEKQLEQFQKSPGFWLLLLEILANSEDQYVRQLAAITLKNKITRRwSSLPEEEKEEIKNSLLELLLS 67
IBN_N pfam03810
Importin-beta N-terminal domain;
30-95 3.10e-10

Importin-beta N-terminal domain;


Pssm-ID: 397745 [Multi-domain]  Cd Length: 72  Bit Score: 57.25  E-value: 3.10e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 672066912    30 AEKALLELIDSPECLSKCQLLLEQGTTS-YAQLLAATCLSKLVTRI-----NPLPVEQRIDIRNYILNYVAS 95
Cdd:pfam03810    1 AEKQLEQFEKSPGFWSKLLQILSNSENPlEVRQLAALYLKNLITRHweeekNSLPPEEKEQIKNNLLNLLGS 72
CRM1 COG5101
Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular ...
 8-167 9.99e-04

Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion];


Pssm-ID: 227432 [Multi-domain]  Cd Length: 1053  Bit Score: 43.39  E-value: 9.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672066912    8 LAELEALCTHLYVGTDLNERiEAEKALLELIDSPECLSKCQLLLEQGTTSYAQLLAATCLSKLV-TRINPLPVEQRIDIR 86
Cdd:COG5101    13 IALLDKVVTTFYQGDGRKQE-QAQRILTKFQELPDAWTKADYILNNSKLPQSKYIALSLLDKLItTKWKLLPEGMRQGIR 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672066912   87 NYILNYVASQPKLAPfVIQALIQVIAKLtKLGWFEVQKDEFVFR--EIIADVKKFLQGTVEHCIIGVIILSELTQEmnLV 164
Cdd:COG5101    92 NYVVQLVIEKSQDDK-VRDKQKYVLNKL-DLTLVQILKQEWPRNwpTFIPELINVSQISMEVCENNMIVLKLLSEE--VF 167


                  ...
gi 672066912  165 DYS 167
Cdd:COG5101   168 DFS 170
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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