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Conserved domains on  [gi|672068979|ref|XP_008766360|]
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ankyrin repeat domain-containing protein 13B isoform X3 [Rattus norvegicus]

Protein Classification

GPCR_chapero_1 domain-containing protein( domain architecture ID 12790908)

GPCR_chapero_1 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GPCR_chapero_1 pfam11904
GPCR-chaperone; This domain, and the associated ANK family repeat pfam00023 domain, together ...
 163-490 7.99e-141

GPCR-chaperone; This domain, and the associated ANK family repeat pfam00023 domain, together act as a chaperone for biogenesis and folding of the DP receptor for prostaglandin D2.


:

Pssm-ID: 463391  Cd Length: 298  Bit Score: 409.33  E-value: 7.99e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672068979  163 RVDTTLLGFDHMTWQRGNRSFVFRGQDTS-AVVMEIDHDRRVVYMETLALAGQDRElllaasqpSEEQVLSRLTAPVVTT 241
Cdd:pfam11904   1 RADTTLLGFDGFKWQRGDQSFLFLGDGDSpGSLLELDHDEKEVQLEGAGAEASEEE--------VEEEVAARLQTPIVRP 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672068979  242 QLDTKNISFERNKTGilgW-RSEKTEMVNGYEAKVYGASNVELITRTRTEHLSEQHKGKVK-------GCKTPLQSFLGI 313
Cdd:pfam11904  73 GIDVTKISFERNKSG---WrRQEKTEMVGGYKAKVYDASNVELSTKSRTEHLSEEEKAKLKsaleppeGSRTPLQSFLGI 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672068979  314 AEQHGGPQNGTLITQTLSQANPPAITAEEYFNPnfelgnrdmgrPMELTTKTQKFKAKLWLCEEHPLSLcEQVAPIIDLM 393
Cdd:pfam11904 150 AEEEKGWFGKTREESEAPPTNPTALTPEEYFDP-----------PKEESEKKKGFKATLWLSEDFPLSL-EQLLPILDLL 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672068979  394 AVSNALFAKLRDFITLRLPPGFPVKIEIPIFHILNARITFGNLNGCDePVPSVRGSPSSETPSPGsdsssvsssssttsc 473
Cdd:pfam11904 218 ANKVKHFRRLREFITLKLPPGFPVKIEIPVFPTVNARITFTKFEELD-PVEEFSTPIKSPERGSP--------------- 281

                         330
                  ....*....|....*..
gi 672068979  474 RACEISPALFEAPRGYS 490
Cdd:pfam11904 282 SSCEIDDDPFEIPSGYT 298
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
4-103 3.17e-16

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 79.23  E-value: 3.17e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672068979   4 ANASARKGPEGKYPLHYLVWHNRHRELEKEVRAGqVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWT 83
Cdd:COG0666   77 GADINAKDDGGNTLLHAAARNGDLEIVKLLLEAG-ADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNT 155

                         90       100
                 ....*....|....*....|
gi 672068979  84 VLQEAVSTRDLELVQLVLRY 103
Cdd:COG0666  156 PLHLAAANGNLEIVKLLLEA 175
 
Name Accession Description Interval E-value
GPCR_chapero_1 pfam11904
GPCR-chaperone; This domain, and the associated ANK family repeat pfam00023 domain, together ...
 163-490 7.99e-141

GPCR-chaperone; This domain, and the associated ANK family repeat pfam00023 domain, together act as a chaperone for biogenesis and folding of the DP receptor for prostaglandin D2.


Pssm-ID: 463391  Cd Length: 298  Bit Score: 409.33  E-value: 7.99e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672068979  163 RVDTTLLGFDHMTWQRGNRSFVFRGQDTS-AVVMEIDHDRRVVYMETLALAGQDRElllaasqpSEEQVLSRLTAPVVTT 241
Cdd:pfam11904   1 RADTTLLGFDGFKWQRGDQSFLFLGDGDSpGSLLELDHDEKEVQLEGAGAEASEEE--------VEEEVAARLQTPIVRP 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672068979  242 QLDTKNISFERNKTGilgW-RSEKTEMVNGYEAKVYGASNVELITRTRTEHLSEQHKGKVK-------GCKTPLQSFLGI 313
Cdd:pfam11904  73 GIDVTKISFERNKSG---WrRQEKTEMVGGYKAKVYDASNVELSTKSRTEHLSEEEKAKLKsaleppeGSRTPLQSFLGI 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672068979  314 AEQHGGPQNGTLITQTLSQANPPAITAEEYFNPnfelgnrdmgrPMELTTKTQKFKAKLWLCEEHPLSLcEQVAPIIDLM 393
Cdd:pfam11904 150 AEEEKGWFGKTREESEAPPTNPTALTPEEYFDP-----------PKEESEKKKGFKATLWLSEDFPLSL-EQLLPILDLL 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672068979  394 AVSNALFAKLRDFITLRLPPGFPVKIEIPIFHILNARITFGNLNGCDePVPSVRGSPSSETPSPGsdsssvsssssttsc 473
Cdd:pfam11904 218 ANKVKHFRRLREFITLKLPPGFPVKIEIPVFPTVNARITFTKFEELD-PVEEFSTPIKSPERGSP--------------- 281

                         330
                  ....*....|....*..
gi 672068979  474 RACEISPALFEAPRGYS 490
Cdd:pfam11904 282 SSCEIDDDPFEIPSGYT 298
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
4-103 3.17e-16

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 79.23  E-value: 3.17e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672068979   4 ANASARKGPEGKYPLHYLVWHNRHRELEKEVRAGqVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWT 83
Cdd:COG0666   77 GADINAKDDGGNTLLHAAARNGDLEIVKLLLEAG-ADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNT 155

                         90       100
                 ....*....|....*....|
gi 672068979  84 VLQEAVSTRDLELVQLVLRY 103
Cdd:COG0666  156 PLHLAAANGNLEIVKLLLEA 175
Ank_2 pfam12796
Ankyrin repeats (3 copies);
18-101 1.10e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 60.90  E-value: 1.10e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672068979   18 LHYLVWHNrHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGAdvGRENRSGWTVLQEAVSTRDLELV 97
Cdd:pfam12796   1 LHLAAKNG-NLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD--VNLKDNGRTALHYAARSGHLEIV 77


                  ....
gi 672068979   98 QLVL 101
Cdd:pfam12796  78 KLLL 81
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 37-103 7.42e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 58.37  E-value: 7.42e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 672068979  37 GQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVLRY 103
Cdd:PTZ00322 104 GGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRH 170
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 47-74 5.09e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 40.26  E-value: 5.09e-05
                           10        20
                   ....*....|....*....|....*...
gi 672068979    47 RGRTPLHLATTLGHLECARVLLAHGADV 74
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADI 28
 
Name Accession Description Interval E-value
GPCR_chapero_1 pfam11904
GPCR-chaperone; This domain, and the associated ANK family repeat pfam00023 domain, together ...
 163-490 7.99e-141

GPCR-chaperone; This domain, and the associated ANK family repeat pfam00023 domain, together act as a chaperone for biogenesis and folding of the DP receptor for prostaglandin D2.


Pssm-ID: 463391  Cd Length: 298  Bit Score: 409.33  E-value: 7.99e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672068979  163 RVDTTLLGFDHMTWQRGNRSFVFRGQDTS-AVVMEIDHDRRVVYMETLALAGQDRElllaasqpSEEQVLSRLTAPVVTT 241
Cdd:pfam11904   1 RADTTLLGFDGFKWQRGDQSFLFLGDGDSpGSLLELDHDEKEVQLEGAGAEASEEE--------VEEEVAARLQTPIVRP 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672068979  242 QLDTKNISFERNKTGilgW-RSEKTEMVNGYEAKVYGASNVELITRTRTEHLSEQHKGKVK-------GCKTPLQSFLGI 313
Cdd:pfam11904  73 GIDVTKISFERNKSG---WrRQEKTEMVGGYKAKVYDASNVELSTKSRTEHLSEEEKAKLKsaleppeGSRTPLQSFLGI 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672068979  314 AEQHGGPQNGTLITQTLSQANPPAITAEEYFNPnfelgnrdmgrPMELTTKTQKFKAKLWLCEEHPLSLcEQVAPIIDLM 393
Cdd:pfam11904 150 AEEEKGWFGKTREESEAPPTNPTALTPEEYFDP-----------PKEESEKKKGFKATLWLSEDFPLSL-EQLLPILDLL 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672068979  394 AVSNALFAKLRDFITLRLPPGFPVKIEIPIFHILNARITFGNLNGCDePVPSVRGSPSSETPSPGsdsssvsssssttsc 473
Cdd:pfam11904 218 ANKVKHFRRLREFITLKLPPGFPVKIEIPVFPTVNARITFTKFEELD-PVEEFSTPIKSPERGSP--------------- 281

                         330
                  ....*....|....*..
gi 672068979  474 RACEISPALFEAPRGYS 490
Cdd:pfam11904 282 SSCEIDDDPFEIPSGYT 298
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
4-103 3.17e-16

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 79.23  E-value: 3.17e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672068979   4 ANASARKGPEGKYPLHYLVWHNRHRELEKEVRAGqVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWT 83
Cdd:COG0666   77 GADINAKDDGGNTLLHAAARNGDLEIVKLLLEAG-ADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNT 155

                         90       100
                 ....*....|....*....|
gi 672068979  84 VLQEAVSTRDLELVQLVLRY 103
Cdd:COG0666  156 PLHLAAANGNLEIVKLLLEA 175
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
10-103 8.61e-16

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 78.07  E-value: 8.61e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672068979  10 KGPEGKYPLHYLVWHNRHRELEKEVRAGqVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAV 89
Cdd:COG0666  116 RDKDGETPLHLAAYNGNLEIVKLLLEAG-ADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAA 194

                         90
                 ....*....|....
gi 672068979  90 STRDLELVQLVLRY 103
Cdd:COG0666  195 ENGHLEIVKLLLEA 208
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
10-104 1.75e-14

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 74.22  E-value: 1.75e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672068979  10 KGPEGKYPLHYLVWHNrHRELEKE-VRAGqVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEA 88
Cdd:COG0666  149 QDNDGNTPLHLAAANG-NLEIVKLlLEAG-ADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLA 226

                         90
                 ....*....|....*.
gi 672068979  89 VSTRDLELVQLVLRYR 104
Cdd:COG0666  227 AENGNLEIVKLLLEAG 242
Ank_2 pfam12796
Ankyrin repeats (3 copies);
18-101 1.10e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 60.90  E-value: 1.10e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672068979   18 LHYLVWHNrHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGAdvGRENRSGWTVLQEAVSTRDLELV 97
Cdd:pfam12796   1 LHLAAKNG-NLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD--VNLKDNGRTALHYAARSGHLEIV 77


                  ....
gi 672068979   98 QLVL 101
Cdd:pfam12796  78 KLLL 81
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
4-103 6.19e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 63.43  E-value: 6.19e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672068979   4 ANASARKGPEGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWT 83
Cdd:COG0666   43 ALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGET 122

                         90       100
                 ....*....|....*....|
gi 672068979  84 VLQEAVSTRDLELVQLVLRY 103
Cdd:COG0666  123 PLHLAAYNGNLEIVKLLLEA 142
Ank_4 pfam13637
Ankyrin repeats (many copies);
48-101 4.82e-10

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 55.36  E-value: 4.82e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 672068979   48 GRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVL 101
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_5 pfam13857
Ankyrin repeats (many copies);
34-88 7.18e-09

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 51.96  E-value: 7.18e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 672068979   34 VRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEA 88
Cdd:pfam13857   2 LEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 37-103 7.42e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 58.37  E-value: 7.42e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 672068979  37 GQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVLRY 103
Cdd:PTZ00322 104 GGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRH 170
Ank_2 pfam12796
Ankyrin repeats (3 copies);
12-78 4.62e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 50.88  E-value: 4.62e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 672068979   12 PEGKYPLHYLVwHNRHRELekeVRA--GQVDIEqLDPRGRTPLHLATTLGHLECARVLLAHGADVGREN 78
Cdd:pfam12796  28 KNGRTALHLAA-KNGHLEI---VKLllEHADVN-LKDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
52-105 5.95e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 50.50  E-value: 5.95e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 672068979   52 LHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVLRYRD 105
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD 54
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 10-104 3.02e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 53.07  E-value: 3.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672068979  10 KGPEGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAV 89
Cdd:PHA02875  64 KYPDIESELHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAV 143

                         90
                 ....*....|....*
gi 672068979  90 STRDLELVQLVLRYR 104
Cdd:PHA02875 144 MMGDIKGIELLIDHK 158
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
10-104 3.10e-07

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 52.26  E-value: 3.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672068979  10 KGPEGKYPLHYLVWHNRHRELEKEVRAGqVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAV 89
Cdd:COG0666  182 RDNDGETPLHLAAENGHLEIVKLLLEAG-ADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAA 260

                         90
                 ....*....|....*
gi 672068979  90 STRDLELVQLVLRYR 104
Cdd:COG0666  261 AAGAALIVKLLLLAL 275
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 30-92 1.68e-06

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 51.02  E-value: 1.68e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 672068979  30 LEKEVRAGQvDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTR 92
Cdd:PLN03192 541 LEELLKAKL-DPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAK 602
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 47-79 2.08e-06

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 44.20  E-value: 2.08e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 672068979   47 RGRTPLHLA-TTLGHLECARVLLAHGADVGRENR 79
Cdd:pfam00023   1 DGNTPLHLAaGRRGNLEIVKLLLSKGADVNARDK 34
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 47-74 5.09e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 40.26  E-value: 5.09e-05
                           10        20
                   ....*....|....*....|....*...
gi 672068979    47 RGRTPLHLATTLGHLECARVLLAHGADV 74
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADI 28
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 47-74 2.93e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 38.39  E-value: 2.93e-04
                          10        20
                  ....*....|....*....|....*...
gi 672068979   47 RGRTPLHLATTLGHLECARVLLAHGADV 74
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADI 28
PHA03095 PHA03095
ankyrin-like protein; Provisional
 10-86 3.52e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 43.09  E-value: 3.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672068979  10 KGPEGKYPLHYLVwHNRHRELEKEVR----AGqVDIEQLDPRGRTPLHL----ATTLghlECARVLLAHGADVGRENRSG 81
Cdd:PHA03095  43 RGEYGKTPLHLYL-HYSSEKVKDIVRllleAG-ADVNAPERCGFTPLHLylynATTL---DVIKLLIKAGADVNAKDKVG 117


                 ....*
gi 672068979  82 WTVLQ 86
Cdd:PHA03095 118 RTPLH 122
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 37-104 6.54e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 42.74  E-value: 6.54e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672068979  37 GQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVLRYR 104
Cdd:PHA02876 167 GGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNR 234
PHA03095 PHA03095
ankyrin-like protein; Provisional
 14-102 8.10e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 41.93  E-value: 8.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672068979  14 GKYPLHYLVWHNRHRELEKE-VRAGqVDIEQLDPRGRTPLH--LATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVS 90
Cdd:PHA03095  83 GFTPLHLYLYNATTLDVIKLlIKAG-ADVNAKDKVGRTPLHvyLSGFNINPKVIRLLLRKGADVNALDLYGMTPLAVLLK 161

                         90
                 ....*....|....
gi 672068979  91 TR--DLELVQLVLR 102
Cdd:PHA03095 162 SRnaNVELLRLLID 175
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 39-105 1.63e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 41.19  E-value: 1.63e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 672068979  39 VDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVLRYRD 105
Cdd:PHA03100 183 VPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGP 249
PHA03095 PHA03095
ankyrin-like protein; Provisional
 14-102 1.75e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 41.16  E-value: 1.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672068979  14 GKYPLHYLVWHNRHRE--LEKEVRAGqVDIEQLDPRGRTPLHLATTLG-HLECARvLLAHGADVGRENRSGWTVLQEAVS 90
Cdd:PHA03095 222 GNTPLHSMATGSSCKRslVLPLLIAG-ISINARNRYGQTPLHYAAVFNnPRACRR-LIALGADINAVSSDGNTPLSLMVR 299

                         90
                 ....*....|..
gi 672068979  91 TRDLELVQLVLR 102
Cdd:PHA03095 300 NNNGRAVRAALA 311
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 15-103 2.09e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 40.63  E-value: 2.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672068979  15 KYPLHYLVWHNRHRELEKEVRAGQvDIEQLDPRGRTPLHLATT-LGHLECARVLLAHGADVGRENR-SGWTVLQeaVSTR 92
Cdd:PHA02878 202 NSPLHHAVKHYNKPIVHILLENGA-STDARDKCGNTPLHISVGyCKDYDILKLLLEHGVDVNAKSYiLGLTALH--SSIK 278

                         90
                 ....*....|.
gi 672068979  93 DLELVQLVLRY 103
Cdd:PHA02878 279 SERKLKLLLEY 289
PHA02795 PHA02795
ankyrin-like protein; Provisional
 40-102 5.42e-03

ankyrin-like protein; Provisional


Pssm-ID: 165157 [Multi-domain]  Cd Length: 437  Bit Score: 39.59  E-value: 5.42e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672068979  40 DIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAV------STRD--LELVQLVLR 102
Cdd:PHA02795 213 DINQLDAGGRTLLYRAIYAGYIDLVSWLLENGANVNAVMSNGYTCLDVAVdrgsviARREthLKILEILLR 283
PHA02917 PHA02917
ankyrin-like protein; Provisional
 40-104 9.24e-03

ankyrin-like protein; Provisional


Pssm-ID: 165231 [Multi-domain]  Cd Length: 661  Bit Score: 38.83  E-value: 9.24e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 672068979  40 DIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVS-TRDLELVQLVLRYR 104
Cdd:PHA02917 444 DINMIDKRGETLLHKAVRYNKQSLVSLLLESGSDVNIRSNNGYTCIAIAINeSRNIELLKMLLCHK 509
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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