|
Name |
Accession |
Description |
Interval |
E-value |
| RFC1 |
pfam08519 |
Replication factor RFC1 C terminal domain; This is the C terminal domain of replication factor ... |
896-1049 |
1.55e-74 |
|
Replication factor RFC1 C terminal domain; This is the C terminal domain of replication factor C, RFC1. RFC complexes hydrolyse ATP and load sliding clamps such as PCNA (proliferating cell nuclear antigen) onto double-stranded DNA. RFC1 is essential for RFC function in vivo.
Pssm-ID: 462507 Cd Length: 158 Bit Score: 243.25 E-value: 1.55e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 896 ICDGDLVDNQIRSKQNWSLLPTQAIYASVVPGELMRGYMSQFPSFPSWLGKHSSTGKHDRTVQDLSLHMSLRTYSSKRTV 975
Cdd:pfam08519 1 ISDGDLVDRMIRGEQQWSLLPTHAVFSSVRPASFMRGSMTGRINFPSWLGKNSKTGKNKRLLQELQYHMRLKTSGDKSEL 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672076196 976 NMDYLSHIRDALVRPLTSQGVEGVQRVVTLMDTYYLVKEDFDNIMEVSSWG----GKPSTFSKLDPKVKAAFTRAYNK 1049
Cdd:pfam08519 81 RLDYLPLLRKRLTQPLLEEGKDGVDEVIDLMDEYYLTKEDWDNIVELSTWGvgpyGEEDPLKKIDTKVKAAFTRKYNK 158
|
|
| PRK04195 |
PRK04195 |
replication factor C large subunit; Provisional |
566-984 |
8.50e-53 |
|
replication factor C large subunit; Provisional
Pssm-ID: 235250 [Multi-domain] Cd Length: 482 Bit Score: 193.21 E-value: 8.50e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 566 LLWVDKYKPTSLKNIIGQQgdqSCANKLLRWLRNWHKSSPEekkhakfgkvaskddgssfKAALLSGPPGVGKTTTASLV 645
Cdd:PRK04195 2 MPWVEKYRPKTLSDVVGNE---KAKEQLREWIESWLKGKPK-------------------KALLLYGPPGVGKTSLAHAL 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 646 CQELGYSYVELNASDTRSKNSLKAIVAESLNNTSIKGfytsgaspsvSARHALIMDEVDGMAGNEDRGGIQELIGLIKHT 725
Cdd:PRK04195 60 ANDYGWEVIELNASDQRTADVIERVAGEAATSGSLFG----------ARRKLILLDEVDGIHGNEDRGGARAILELIKKA 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 726 KIPIICMCNDRNHPKIRSLVHYCFDLRFQRPRVEQIKSAMLSIAFKEGLKIPPPAMNEIILGANQDVRQVLHNLSMWCAQ 805
Cdd:PRK04195 130 KQPIILTANDPYDPSLRELRNACLMIEFKRLSTRSIVPVLKRICRKEGIECDDEALKEIAERSGGDLRSAINDLQAIAEG 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 806 SKVLTYDQAKADSQRakkDIRLGPFDVTRKVFAA-GEETAHMSLMDkSDLFFHDYSiapLFVQEN----YLHVKPVAAGG 880
Cdd:PRK04195 210 YGKLTLEDVKTLGRR---DREESIFDALDAVFKArNADQALEASYD-VDEDPDDLI---EWIDENipkeYDDPEDIARAY 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 881 DMkkhlmlLSRAadsicdgDLVDNQIRSKQNWSLLPtqaiYASvvpgELMRG---YMSQFP-------SFPSWLGKHSST 950
Cdd:PRK04195 283 DA------LSRA-------DIFLGRVKRTQNYDLWR----YAS----DLMTAgvaLAKEKKkrgftryQPPSYWRLLSKT 341
|
410 420 430
....*....|....*....|....*....|....
gi 672076196 951 GKHDRTVQDLSLHMSLRTYSSKRTVNMDYLSHIR 984
Cdd:PRK04195 342 KEKRETRDSIAKKIAEKLHTSKRKVRREVLPFLS 375
|
|
| BRCT_RFC1 |
cd17752 |
BRCT domain of replication factor C subunit 1 (RFC1) and similar proteins; RFC1, also termed ... |
397-475 |
2.55e-47 |
|
BRCT domain of replication factor C subunit 1 (RFC1) and similar proteins; RFC1, also termed activator 1 140 kDa subunit, or A1 140 kDa subunit, or activator 1 large subunit, or activator 1 subunit 1, or replication factor C 140 kDa subunit, or RF-C 140 kDa subunit, or RFC140, is the large subunit of replication factor C (RFC), which is a heteropentameric protein essential for DNA replication and repair. RFC1 can bind single- or double-stranded DNA. It could play a role in DNA transcription regulation as well as DNA replication and/or repair. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is not conserved in this family.
Pssm-ID: 349383 [Multi-domain] Cd Length: 79 Bit Score: 163.15 E-value: 2.55e-47
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 672076196 397 GAENCLEGLTFVITGVLESIEREEAKSLIERYGGKVTGNVSKKTSYLVMGRDSGQSKSDKAAALGTKILDEDGLLDLIR 475
Cdd:cd17752 1 GAPNCLEGLTFVITGVLESLEREEAEDLIKRYGGKVTGSVSKKTSYLVVGRDAGPSKLEKAKELGTKIIDEDGLFDLIR 79
|
|
| Lig |
COG0272 |
NAD-dependent DNA ligase [Replication, recombination and repair]; |
393-474 |
2.32e-28 |
|
NAD-dependent DNA ligase [Replication, recombination and repair];
Pssm-ID: 440042 [Multi-domain] Cd Length: 668 Bit Score: 122.44 E-value: 2.32e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 393 EIPKGAENCLEGLTFVITGVLESIEREEAKSLIERYGGKVTGNVSKKTSYLVMGRDSGqSKSDKAAALGTKILDEDGLLD 472
Cdd:COG0272 587 EAEAAADSPLAGKTFVLTGTLETMTRDEAKELIEALGGKVSGSVSKKTDYVVAGENAG-SKLDKAEELGVPILDEAEFLE 665
|
..
gi 672076196 473 LI 474
Cdd:COG0272 666 LL 667
|
|
| ligA |
PRK07956 |
NAD-dependent DNA ligase LigA; Validated |
387-474 |
2.48e-25 |
|
NAD-dependent DNA ligase LigA; Validated
Pssm-ID: 236137 [Multi-domain] Cd Length: 665 Bit Score: 112.91 E-value: 2.48e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 387 KALGSKEIPKGAENCLEGLTFVITGVLESIEREEAKSLIERYGGKVTGNVSKKTSYLVMGRDSGqSKSDKAAALGTKILD 466
Cdd:PRK07956 576 LEAGVNMEYKGEEVDLAGKTVVLTGTLEQLSRDEAKEKLEALGAKVSGSVSKKTDLVVAGEAAG-SKLAKAQELGIEVLD 654
|
....*...
gi 672076196 467 EDGLLDLI 474
Cdd:PRK07956 655 EEEFLRLL 662
|
|
| AAA |
pfam00004 |
ATPase family associated with various cellular activities (AAA); AAA family proteins often ... |
629-757 |
3.26e-17 |
|
ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.
Pssm-ID: 459627 [Multi-domain] Cd Length: 130 Bit Score: 79.17 E-value: 3.26e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 629 LLSGPPGVGKTTTASLVCQELGYSYVELNASDTRSKnslkaIVAESLNNtsIKGFYT--SGASPSVsarhaLIMDEVDGM 706
Cdd:pfam00004 2 LLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSK-----YVGESEKR--LRELFEaaKKLAPCV-----IFIDEIDAL 69
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 672076196 707 AGNEDRGGIQELIGLI------------KHTKIPIICMCNdrNHPKIRSLVHYCFDLRFQRPR 757
Cdd:pfam00004 70 AGSRGSGGDSESRRVVnqllteldgftsSNSKVIVIAATN--RPDKLDPALLGRFDRIIEFPL 130
|
|
| BRCT |
pfam00533 |
BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in ... |
399-474 |
3.32e-16 |
|
BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. The BRCT domain of XRCC1 forms a homodimer in the crystal structure. This suggests that pairs of BRCT domains associate as homo- or heterodimers. BRCT domains are often found as tandem-repeat pairs. Structures of the BRCA1 BRCT domains revealed a basis for a widely utilized head-to-tail BRCT-BRCT oligomerization mode. This conserved tandem BRCT architecture facilitates formation of the canonical BRCT phospho-peptide interaction cleft at a groove between the BRCT domains. Disease associated missense and nonsense mutations in the BRCA1 BRCT domains disrupt peptide binding by directly occluding this peptide binding groove, or by disrupting key conserved BRCT core folding determinants.
Pssm-ID: 425736 [Multi-domain] Cd Length: 75 Bit Score: 74.25 E-value: 3.32e-16
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 672076196 399 ENCLEGLTFVITGvLESIEREEAKSLIERYGGKVTGNVSKKTSYLVMgrDSGQSKSDKAAALGTKILDEDGLLDLI 474
Cdd:pfam00533 3 EKLFSGKTFVITG-LDGLERDELKELIEKLGGKVTDSLSKKTTHVIV--EARTKKYLKAKELGIPIVTEEWLLDCI 75
|
|
| AAA |
cd00009 |
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ... |
615-753 |
5.44e-15 |
|
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.
Pssm-ID: 99707 [Multi-domain] Cd Length: 151 Bit Score: 73.33 E-value: 5.44e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 615 KVASKDDGSSFKAALLSGPPGVGKTTTASLVCQEL---GYSYVELNASDTRSKNSLKAIVAESLNNtsIKGFYTSGASPS 691
Cdd:cd00009 9 ALREALELPPPKNLLLYGPPGTGKTTLARAIANELfrpGAPFLYLNASDLLEGLVVAELFGHFLVR--LLFELAEKAKPG 86
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 672076196 692 VsarhaLIMDEVDGMAGNEDRGGIQEL----IGLIKHTKIPIICMCNDRNHPKIRSLVHYCFDLRF 753
Cdd:cd00009 87 V-----LFIDEIDSLSRGAQNALLRVLetlnDLRIDRENVRVIGATNRPLLGDLDRALYDRLDIRI 147
|
|
| BRCT |
smart00292 |
breast cancer carboxy-terminal domain; |
399-474 |
2.94e-14 |
|
breast cancer carboxy-terminal domain;
Pssm-ID: 214602 [Multi-domain] Cd Length: 78 Bit Score: 68.94 E-value: 2.94e-14
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672076196 399 ENCLEGLTFVITGVLESIEREEAKSLIERYGGKVTGNVSKKTSYLVMGRDSGQSKSDKAAA--LGTKILDEDGLLDLI 474
Cdd:smart00292 1 PKLFKGKTFYITGSFDKEERDELKELIEALGGKVTSSLSSKTTTHVIVGSPEGGKLELLKAiaLGIPIVKEEWLLDCL 78
|
|
| AAA |
smart00382 |
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ... |
629-759 |
2.24e-09 |
|
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.
Pssm-ID: 214640 [Multi-domain] Cd Length: 148 Bit Score: 57.38 E-value: 2.24e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 629 LLSGPPGVGKTTTASLVCQEL---GYSYVELNASDTRSKNSLKAIVaesLNNTSIKGFYTSGASPSVSARHA-------L 698
Cdd:smart00382 6 LIVGPPGSGKTTLARALARELgppGGGVIYIDGEDILEEVLDQLLL---IIVGGKKASGSGELRLRLALALArklkpdvL 82
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 672076196 699 IMDEVDGMAGNEDRGGIQE------LIGLIKHTKIPIICMCNDRNHPKIRSLVHyCFDLRFQRPRVE 759
Cdd:smart00382 83 ILDEITSLLDAEQEALLLLleelrlLLLLKSEKNLTVILTTNDEKDLGPALLRR-RFDRRIVLLLIL 148
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
11-562 |
3.52e-09 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 61.31 E-value: 3.52e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 11 SSGKKPVNETVKKNEKTKPSEgtvKGKKGVKEAKVnnpcKEDASRPKQHNKKKRiiydsdseseETVQVKNAKKKSEKLP 90
Cdd:PTZ00121 1298 AEEKKKADEAKKKAEEAKKAD---EAKKKAEEAKK----KADAAKKKAEEAKKA----------AEAAKAEAEAAADEAE 1360
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 91 VSCKPGKISRKDPvtyiSETDEDDDFLCKKAASKSKengvstnsylgASNVKKNEENTKTKSKPLspikltptsvldyfg 170
Cdd:PTZ00121 1361 AAEEKAEAAEKKK----EEAKKKADAAKKKAEEKKK-----------ADEAKKKAEEDKKKADEL--------------- 1410
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 171 tesvqrsgKKMVASKKK--ESSQTPDDSRLNDEAIAKQLQLDEDAELERQLHEDEEFARTLALLDEEPKTKKARKDSEEG 248
Cdd:PTZ00121 1411 --------KKAAAAKKKadEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEA 1482
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 249 ESFSPAKA----------ELSKAAKQKSPANEhfsiGRKTYSPAKYGKGRGSEGTKQP--CRSAHQKEACSSLKASSKLA 316
Cdd:PTZ00121 1483 KKADEAKKkaeeakkkadEAKKAAEAKKKADE----AKKAEEAKKADEAKKAEEAKKAdeAKKAEEKKKADELKKAEELK 1558
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 317 L---MKAQEENSYKETELLAAKRESAIEPKGEKTTPRKTKGSPTKRESVSPEDSEKKRTNYQAYRSYLNREGPKALGSKE 393
Cdd:PTZ00121 1559 KaeeKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQL 1638
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 394 IPKGAENCLEGltfvitgvlESIEREEAKSLIERYGGKVTGNVSKKTSYLVmgRDSGQSKSDKAAALGTKILDEDGLLDL 473
Cdd:PTZ00121 1639 KKKEAEEKKKA---------EELKKAEEENKIKAAEEAKKAEEDKKKAEEA--KKAEEDEKKAAEALKKEAEEAKKAEEL 1707
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 474 IRTMPGKKSKYEIAAEAEmKKEKSKLERTPQKNDQGKRKLSPTKRELEPKKSKLTPLKHSPRKAV---KEEERVCPRGLD 550
Cdd:PTZ00121 1708 KKKEAEEKKKAEELKKAE-EENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEeirKEKEAVIEEELD 1786
|
570
....*....|..
gi 672076196 551 AKEPHGSHSASR 562
Cdd:PTZ00121 1787 EEDEKRRMEVDK 1798
|
|
| SpoVK |
COG0464 |
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ... |
592-714 |
5.01e-07 |
|
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 440232 [Multi-domain] Cd Length: 397 Bit Score: 53.38 E-value: 5.01e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 592 KLLRWLRNWHKSSPEEKKHAKFGKVaskddgssfKAALLSGPPGVGKTTTASLVCQELGYSYVELNASDTRSK------N 665
Cdd:COG0464 167 EELRELVALPLKRPELREEYGLPPP---------RGLLLYGPPGTGKTLLARALAGELGLPLIEVDLSDLVSKyvgeteK 237
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 672076196 666 SLKAIVAESLnntsikgfytsGASPSVsarhaLIMDEVDGMAGNEDRGG 714
Cdd:COG0464 238 NLREVFDKAR-----------GLAPCV-----LFIDEADALAGKRGEVG 270
|
|
| rad24 |
TIGR00602 |
checkpoint protein rad24; All proteins in this family for which functions are known are ... |
531-655 |
2.95e-04 |
|
checkpoint protein rad24; All proteins in this family for which functions are known are involved in DNA damage tolerance (likely cell cycle checkpoints).This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 129690 [Multi-domain] Cd Length: 637 Bit Score: 44.95 E-value: 2.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 531 KHSPRKAVKEEERvcpRGLDAKEPHGSHSASREEC--LLWVDKYKPTSlkniigqQGDQSCANKLLRWLRNWHKS-SPEE 607
Cdd:TIGR00602 38 KNSPSTDIHARKR---GFLSLEQDTGLELSSENLDgnEPWVEKYKPET-------QHELAVHKKKIEEVETWLKAqVLEN 107
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 672076196 608 KKHakfgkvaskddgssfKAALLSGPPGVGKTTTASLVCQELGYSYVE 655
Cdd:TIGR00602 108 APK---------------RILLITGPSGCGKSTTIKILSKELGIQVQE 140
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| RFC1 |
pfam08519 |
Replication factor RFC1 C terminal domain; This is the C terminal domain of replication factor ... |
896-1049 |
1.55e-74 |
|
Replication factor RFC1 C terminal domain; This is the C terminal domain of replication factor C, RFC1. RFC complexes hydrolyse ATP and load sliding clamps such as PCNA (proliferating cell nuclear antigen) onto double-stranded DNA. RFC1 is essential for RFC function in vivo.
Pssm-ID: 462507 Cd Length: 158 Bit Score: 243.25 E-value: 1.55e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 896 ICDGDLVDNQIRSKQNWSLLPTQAIYASVVPGELMRGYMSQFPSFPSWLGKHSSTGKHDRTVQDLSLHMSLRTYSSKRTV 975
Cdd:pfam08519 1 ISDGDLVDRMIRGEQQWSLLPTHAVFSSVRPASFMRGSMTGRINFPSWLGKNSKTGKNKRLLQELQYHMRLKTSGDKSEL 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672076196 976 NMDYLSHIRDALVRPLTSQGVEGVQRVVTLMDTYYLVKEDFDNIMEVSSWG----GKPSTFSKLDPKVKAAFTRAYNK 1049
Cdd:pfam08519 81 RLDYLPLLRKRLTQPLLEEGKDGVDEVIDLMDEYYLTKEDWDNIVELSTWGvgpyGEEDPLKKIDTKVKAAFTRKYNK 158
|
|
| PRK04195 |
PRK04195 |
replication factor C large subunit; Provisional |
566-984 |
8.50e-53 |
|
replication factor C large subunit; Provisional
Pssm-ID: 235250 [Multi-domain] Cd Length: 482 Bit Score: 193.21 E-value: 8.50e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 566 LLWVDKYKPTSLKNIIGQQgdqSCANKLLRWLRNWHKSSPEekkhakfgkvaskddgssfKAALLSGPPGVGKTTTASLV 645
Cdd:PRK04195 2 MPWVEKYRPKTLSDVVGNE---KAKEQLREWIESWLKGKPK-------------------KALLLYGPPGVGKTSLAHAL 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 646 CQELGYSYVELNASDTRSKNSLKAIVAESLNNTSIKGfytsgaspsvSARHALIMDEVDGMAGNEDRGGIQELIGLIKHT 725
Cdd:PRK04195 60 ANDYGWEVIELNASDQRTADVIERVAGEAATSGSLFG----------ARRKLILLDEVDGIHGNEDRGGARAILELIKKA 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 726 KIPIICMCNDRNHPKIRSLVHYCFDLRFQRPRVEQIKSAMLSIAFKEGLKIPPPAMNEIILGANQDVRQVLHNLSMWCAQ 805
Cdd:PRK04195 130 KQPIILTANDPYDPSLRELRNACLMIEFKRLSTRSIVPVLKRICRKEGIECDDEALKEIAERSGGDLRSAINDLQAIAEG 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 806 SKVLTYDQAKADSQRakkDIRLGPFDVTRKVFAA-GEETAHMSLMDkSDLFFHDYSiapLFVQEN----YLHVKPVAAGG 880
Cdd:PRK04195 210 YGKLTLEDVKTLGRR---DREESIFDALDAVFKArNADQALEASYD-VDEDPDDLI---EWIDENipkeYDDPEDIARAY 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 881 DMkkhlmlLSRAadsicdgDLVDNQIRSKQNWSLLPtqaiYASvvpgELMRG---YMSQFP-------SFPSWLGKHSST 950
Cdd:PRK04195 283 DA------LSRA-------DIFLGRVKRTQNYDLWR----YAS----DLMTAgvaLAKEKKkrgftryQPPSYWRLLSKT 341
|
410 420 430
....*....|....*....|....*....|....
gi 672076196 951 GKHDRTVQDLSLHMSLRTYSSKRTVNMDYLSHIR 984
Cdd:PRK04195 342 KEKRETRDSIAKKIAEKLHTSKRKVRREVLPFLS 375
|
|
| BRCT_RFC1 |
cd17752 |
BRCT domain of replication factor C subunit 1 (RFC1) and similar proteins; RFC1, also termed ... |
397-475 |
2.55e-47 |
|
BRCT domain of replication factor C subunit 1 (RFC1) and similar proteins; RFC1, also termed activator 1 140 kDa subunit, or A1 140 kDa subunit, or activator 1 large subunit, or activator 1 subunit 1, or replication factor C 140 kDa subunit, or RF-C 140 kDa subunit, or RFC140, is the large subunit of replication factor C (RFC), which is a heteropentameric protein essential for DNA replication and repair. RFC1 can bind single- or double-stranded DNA. It could play a role in DNA transcription regulation as well as DNA replication and/or repair. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is not conserved in this family.
Pssm-ID: 349383 [Multi-domain] Cd Length: 79 Bit Score: 163.15 E-value: 2.55e-47
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 672076196 397 GAENCLEGLTFVITGVLESIEREEAKSLIERYGGKVTGNVSKKTSYLVMGRDSGQSKSDKAAALGTKILDEDGLLDLIR 475
Cdd:cd17752 1 GAPNCLEGLTFVITGVLESLEREEAEDLIKRYGGKVTGSVSKKTSYLVVGRDAGPSKLEKAKELGTKIIDEDGLFDLIR 79
|
|
| Lig |
COG0272 |
NAD-dependent DNA ligase [Replication, recombination and repair]; |
393-474 |
2.32e-28 |
|
NAD-dependent DNA ligase [Replication, recombination and repair];
Pssm-ID: 440042 [Multi-domain] Cd Length: 668 Bit Score: 122.44 E-value: 2.32e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 393 EIPKGAENCLEGLTFVITGVLESIEREEAKSLIERYGGKVTGNVSKKTSYLVMGRDSGqSKSDKAAALGTKILDEDGLLD 472
Cdd:COG0272 587 EAEAAADSPLAGKTFVLTGTLETMTRDEAKELIEALGGKVSGSVSKKTDYVVAGENAG-SKLDKAEELGVPILDEAEFLE 665
|
..
gi 672076196 473 LI 474
Cdd:COG0272 666 LL 667
|
|
| ligA |
PRK07956 |
NAD-dependent DNA ligase LigA; Validated |
387-474 |
2.48e-25 |
|
NAD-dependent DNA ligase LigA; Validated
Pssm-ID: 236137 [Multi-domain] Cd Length: 665 Bit Score: 112.91 E-value: 2.48e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 387 KALGSKEIPKGAENCLEGLTFVITGVLESIEREEAKSLIERYGGKVTGNVSKKTSYLVMGRDSGqSKSDKAAALGTKILD 466
Cdd:PRK07956 576 LEAGVNMEYKGEEVDLAGKTVVLTGTLEQLSRDEAKEKLEALGAKVSGSVSKKTDLVVAGEAAG-SKLAKAQELGIEVLD 654
|
....*...
gi 672076196 467 EDGLLDLI 474
Cdd:PRK07956 655 EEEFLRLL 662
|
|
| BRCT_DNA_ligase_like |
cd17748 |
BRCT domain of bacterial NAD-dependent DNA ligase (LigA) and similar proteins; LigA, also ... |
402-473 |
2.68e-24 |
|
BRCT domain of bacterial NAD-dependent DNA ligase (LigA) and similar proteins; LigA, also called NAD(+)-dependent polydeoxyribonucleotide synthase, catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is not conserved in this family.
Pssm-ID: 349379 [Multi-domain] Cd Length: 76 Bit Score: 97.17 E-value: 2.68e-24
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 672076196 402 LEGLTFVITGVLESIEREEAKSLIERYGGKVTGNVSKKTSYLVMGRDSGQSKSD----KAAALGTKILDEDGLLDL 473
Cdd:cd17748 1 LAGKTFVFTGTLSSMSRDEAEELIEALGGKVQSSVSKKTDYLVVGDNAGSKLKKgeelKAKGLGIKIISEEEFLDL 76
|
|
| AAA |
pfam00004 |
ATPase family associated with various cellular activities (AAA); AAA family proteins often ... |
629-757 |
3.26e-17 |
|
ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.
Pssm-ID: 459627 [Multi-domain] Cd Length: 130 Bit Score: 79.17 E-value: 3.26e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 629 LLSGPPGVGKTTTASLVCQELGYSYVELNASDTRSKnslkaIVAESLNNtsIKGFYT--SGASPSVsarhaLIMDEVDGM 706
Cdd:pfam00004 2 LLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSK-----YVGESEKR--LRELFEaaKKLAPCV-----IFIDEIDAL 69
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 672076196 707 AGNEDRGGIQELIGLI------------KHTKIPIICMCNdrNHPKIRSLVHYCFDLRFQRPR 757
Cdd:pfam00004 70 AGSRGSGGDSESRRVVnqllteldgftsSNSKVIVIAATN--RPDKLDPALLGRFDRIIEFPL 130
|
|
| ligA |
PRK14351 |
NAD-dependent DNA ligase LigA; Provisional |
400-472 |
1.20e-16 |
|
NAD-dependent DNA ligase LigA; Provisional
Pssm-ID: 184640 [Multi-domain] Cd Length: 689 Bit Score: 85.19 E-value: 1.20e-16
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 672076196 400 NCLEGLTFVITGVLESIEREEAKSLIERYGGKVTGNVSKKTSYLVMGRDSGQSKSDKAAALGTKILDED---GLLD 472
Cdd:PRK14351 608 DALDGLTFVFTGSLSGYTRSEAQELVEAHGGNATGSVSGNTDYLVVGENPGQSKRDDAEANDVPTLDEEefeELLA 683
|
|
| BRCT |
pfam00533 |
BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in ... |
399-474 |
3.32e-16 |
|
BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. The BRCT domain of XRCC1 forms a homodimer in the crystal structure. This suggests that pairs of BRCT domains associate as homo- or heterodimers. BRCT domains are often found as tandem-repeat pairs. Structures of the BRCA1 BRCT domains revealed a basis for a widely utilized head-to-tail BRCT-BRCT oligomerization mode. This conserved tandem BRCT architecture facilitates formation of the canonical BRCT phospho-peptide interaction cleft at a groove between the BRCT domains. Disease associated missense and nonsense mutations in the BRCA1 BRCT domains disrupt peptide binding by directly occluding this peptide binding groove, or by disrupting key conserved BRCT core folding determinants.
Pssm-ID: 425736 [Multi-domain] Cd Length: 75 Bit Score: 74.25 E-value: 3.32e-16
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 672076196 399 ENCLEGLTFVITGvLESIEREEAKSLIERYGGKVTGNVSKKTSYLVMgrDSGQSKSDKAAALGTKILDEDGLLDLI 474
Cdd:pfam00533 3 EKLFSGKTFVITG-LDGLERDELKELIEKLGGKVTDSLSKKTTHVIV--EARTKKYLKAKELGIPIVTEEWLLDCI 75
|
|
| AAA |
cd00009 |
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ... |
615-753 |
5.44e-15 |
|
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.
Pssm-ID: 99707 [Multi-domain] Cd Length: 151 Bit Score: 73.33 E-value: 5.44e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 615 KVASKDDGSSFKAALLSGPPGVGKTTTASLVCQEL---GYSYVELNASDTRSKNSLKAIVAESLNNtsIKGFYTSGASPS 691
Cdd:cd00009 9 ALREALELPPPKNLLLYGPPGTGKTTLARAIANELfrpGAPFLYLNASDLLEGLVVAELFGHFLVR--LLFELAEKAKPG 86
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 672076196 692 VsarhaLIMDEVDGMAGNEDRGGIQEL----IGLIKHTKIPIICMCNDRNHPKIRSLVHYCFDLRF 753
Cdd:cd00009 87 V-----LFIDEIDSLSRGAQNALLRVLetlnDLRIDRENVRVIGATNRPLLGDLDRALYDRLDIRI 147
|
|
| BRCT |
smart00292 |
breast cancer carboxy-terminal domain; |
399-474 |
2.94e-14 |
|
breast cancer carboxy-terminal domain;
Pssm-ID: 214602 [Multi-domain] Cd Length: 78 Bit Score: 68.94 E-value: 2.94e-14
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672076196 399 ENCLEGLTFVITGVLESIEREEAKSLIERYGGKVTGNVSKKTSYLVMGRDSGQSKSDKAAA--LGTKILDEDGLLDLI 474
Cdd:smart00292 1 PKLFKGKTFYITGSFDKEERDELKELIEALGGKVTSSLSSKTTTHVIVGSPEGGKLELLKAiaLGIPIVKEEWLLDCL 78
|
|
| PLN03025 |
PLN03025 |
replication factor C subunit; Provisional |
568-799 |
3.58e-11 |
|
replication factor C subunit; Provisional
Pssm-ID: 178596 [Multi-domain] Cd Length: 319 Bit Score: 65.91 E-value: 3.58e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 568 WVDKYKPTSLKNIIGqqgDQSCANKLlrwlrnwhksspeekkhakfgKVASKDdgSSFKAALLSGPPGVGKTTTA-SLVC 646
Cdd:PLN03025 3 WVEKYRPTKLDDIVG---NEDAVSRL---------------------QVIARD--GNMPNLILSGPPGTGKTTSIlALAH 56
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 647 QELGYSY----VELNASDTRSKNSLKaivaeslnnTSIKGFytsgASPSVS---ARHAL-IMDEVDGMAGnedrGGIQEL 718
Cdd:PLN03025 57 ELLGPNYkeavLELNASDDRGIDVVR---------NKIKMF----AQKKVTlppGRHKIvILDEADSMTS----GAQQAL 119
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 719 IGLIK----HTKIPIICMCNDRNHPKIRSlvhYCFDLRFQRPRVEQIKSAMLSIAFKEGLKIPPPAMNEIILGANQDVRQ 794
Cdd:PLN03025 120 RRTMEiysnTTRFALACNTSSKIIEPIQS---RCAIVRFSRLSDQEILGRLMKVVEAEKVPYVPEGLEAIIFTADGDMRQ 196
|
....*
gi 672076196 795 VLHNL 799
Cdd:PLN03025 197 ALNNL 201
|
|
| HLD_clamp_RFC |
cd18140 |
helical lid domain of replication factor C subunit; Replication factor C (RFC) is five-protein ... |
756-812 |
3.64e-11 |
|
helical lid domain of replication factor C subunit; Replication factor C (RFC) is five-protein clamp loader complex that forms a stable ATP-dependent complex with the sliding clamp, PCNA, which binds specifically to primed DNA. RFC subunits belong to the clamp loader clade of the AAA+ superfamily.
Pssm-ID: 350842 [Multi-domain] Cd Length: 63 Bit Score: 59.46 E-value: 3.64e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 672076196 756 PRVEQIKSAMLSIAFKEGLKIPPPAMNEIILGANQDVRQVLHNLSMWCAQSKVLTYD 812
Cdd:cd18140 1 LSKEQIVKRLREICKKEGVKIDEEALEAIAEKSEGDMRKAINDLQAAAAGGGVITEE 57
|
|
| BRCT |
cd00027 |
C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The ... |
405-472 |
1.56e-09 |
|
C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The BRCT (BRCA1 C-terminus) domain is found within many DNA damage repair and cell cycle checkpoint proteins. BRCT domains interact with each other forming homo/hetero BRCT multimers, but are also involved in BRCT-non-BRCT interactions and interactions within DNA strand breaks. BRCT tandem repeats bind to phosphopeptides; it has been shown that the repeats in human BRCA1 bind specifically to pS-X-X-F motifs, mediating the interaction between BRCA1 and the DNA helicase BACH1, or BRCA1 and CtIP, a transcriptional corepressor. It is assumed that BRCT repeats play similar roles in many signaling pathways associated with the response to DNA damage.
Pssm-ID: 349339 [Multi-domain] Cd Length: 68 Bit Score: 55.06 E-value: 1.56e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672076196 405 LTFVITGvLESIEREEAKSLIERYGGKVTGNVSKKTSYLVMGRDSGQSKSDKAAALGTKILDEDGLLD 472
Cdd:cd00027 1 LVICFSG-LDDEEREELKKLIEALGGKVSESLSSKVTHLIAKSPSGEKYYLAALAWGIPIVSPEWLLD 67
|
|
| AAA |
smart00382 |
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ... |
629-759 |
2.24e-09 |
|
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.
Pssm-ID: 214640 [Multi-domain] Cd Length: 148 Bit Score: 57.38 E-value: 2.24e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 629 LLSGPPGVGKTTTASLVCQEL---GYSYVELNASDTRSKNSLKAIVaesLNNTSIKGFYTSGASPSVSARHA-------L 698
Cdd:smart00382 6 LIVGPPGSGKTTLARALARELgppGGGVIYIDGEDILEEVLDQLLL---IIVGGKKASGSGELRLRLALALArklkpdvL 82
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 672076196 699 IMDEVDGMAGNEDRGGIQE------LIGLIKHTKIPIICMCNDRNHPKIRSLVHyCFDLRFQRPRVE 759
Cdd:smart00382 83 ILDEITSLLDAEQEALLLLleelrlLLLLKSEKNLTVILTTNDEKDLGPALLRR-RFDRRIVLLLIL 148
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
11-562 |
3.52e-09 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 61.31 E-value: 3.52e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 11 SSGKKPVNETVKKNEKTKPSEgtvKGKKGVKEAKVnnpcKEDASRPKQHNKKKRiiydsdseseETVQVKNAKKKSEKLP 90
Cdd:PTZ00121 1298 AEEKKKADEAKKKAEEAKKAD---EAKKKAEEAKK----KADAAKKKAEEAKKA----------AEAAKAEAEAAADEAE 1360
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 91 VSCKPGKISRKDPvtyiSETDEDDDFLCKKAASKSKengvstnsylgASNVKKNEENTKTKSKPLspikltptsvldyfg 170
Cdd:PTZ00121 1361 AAEEKAEAAEKKK----EEAKKKADAAKKKAEEKKK-----------ADEAKKKAEEDKKKADEL--------------- 1410
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 171 tesvqrsgKKMVASKKK--ESSQTPDDSRLNDEAIAKQLQLDEDAELERQLHEDEEFARTLALLDEEPKTKKARKDSEEG 248
Cdd:PTZ00121 1411 --------KKAAAAKKKadEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEA 1482
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 249 ESFSPAKA----------ELSKAAKQKSPANEhfsiGRKTYSPAKYGKGRGSEGTKQP--CRSAHQKEACSSLKASSKLA 316
Cdd:PTZ00121 1483 KKADEAKKkaeeakkkadEAKKAAEAKKKADE----AKKAEEAKKADEAKKAEEAKKAdeAKKAEEKKKADELKKAEELK 1558
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 317 L---MKAQEENSYKETELLAAKRESAIEPKGEKTTPRKTKGSPTKRESVSPEDSEKKRTNYQAYRSYLNREGPKALGSKE 393
Cdd:PTZ00121 1559 KaeeKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQL 1638
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 394 IPKGAENCLEGltfvitgvlESIEREEAKSLIERYGGKVTGNVSKKTSYLVmgRDSGQSKSDKAAALGTKILDEDGLLDL 473
Cdd:PTZ00121 1639 KKKEAEEKKKA---------EELKKAEEENKIKAAEEAKKAEEDKKKAEEA--KKAEEDEKKAAEALKKEAEEAKKAEEL 1707
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 474 IRTMPGKKSKYEIAAEAEmKKEKSKLERTPQKNDQGKRKLSPTKRELEPKKSKLTPLKHSPRKAV---KEEERVCPRGLD 550
Cdd:PTZ00121 1708 KKKEAEEKKKAEELKKAE-EENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEeirKEKEAVIEEELD 1786
|
570
....*....|..
gi 672076196 551 AKEPHGSHSASR 562
Cdd:PTZ00121 1787 EEDEKRRMEVDK 1798
|
|
| PRK06195 |
PRK06195 |
DNA polymerase III subunit epsilon; Validated |
311-475 |
4.84e-09 |
|
DNA polymerase III subunit epsilon; Validated
Pssm-ID: 235735 [Multi-domain] Cd Length: 309 Bit Score: 59.02 E-value: 4.84e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 311 ASSKLALMKAQEENSYKETEL--LAAKRESAIEPKGEKttPRKTKGSPTKRESvsPEDSEKKRtnyqayrsylnregpka 388
Cdd:PRK06195 152 ACSNILLNISKELNSKDINEIskLLGVTLGYVNENGYK--PSSRKGRILKRSN--RQAPRKKK----------------- 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 389 lgsKEIPKGAENCLEGLTFVITGVLESIEREEAKSLIERYGGKVTGNVSKKTSYLVMG--------RDSGQSKSDKAAAL 460
Cdd:PRK06195 211 ---KIIESFGFTAFKEEVVVFTGGLASMTRDEAMILVRRLGGTVGSSVTKKTTYLVTNtkdiedlnREEMSNKLKKAIDL 287
|
170 180
....*....|....*....|
gi 672076196 461 -----GTKILDEDGLLDLIR 475
Cdd:PRK06195 288 kkkgqNIKFLNEEEFLQKCK 307
|
|
| rfc |
PRK00440 |
replication factor C small subunit; Reviewed |
566-826 |
1.82e-08 |
|
replication factor C small subunit; Reviewed
Pssm-ID: 234763 [Multi-domain] Cd Length: 319 Bit Score: 57.58 E-value: 1.82e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 566 LLWVDKYKPTSLKNIIGQQgdqscanKLLRWLRNWhksspeekkhakfgkVASKDdgssFKAALLSGPPGVGKTTTASLV 645
Cdd:PRK00440 5 EIWVEKYRPRTLDEIVGQE-------EIVERLKSY---------------VKEKN----MPHLLFAGPPGTGKTTAALAL 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 646 CQEL-GYSY----VELNASDTRSKNSLKaivaeslnnTSIKGFytSGASPSVSARHALI-MDEVDGM---AGNEDRgGIQ 716
Cdd:PRK00440 59 ARELyGEDWrenfLELNASDERGIDVIR---------NKIKEF--ARTAPVGGAPFKIIfLDEADNLtsdAQQALR-RTM 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 717 ELIGliKHTKIPIICmcndrNHP-KI------RslvhyCFDLRFQRPRVEQIKSAMLSIAFKEGLKIPPPAMNEIILGAN 789
Cdd:PRK00440 127 EMYS--QNTRFILSC-----NYSsKIidpiqsR-----CAVFRFSPLKKEAVAERLRYIAENEGIEITDDALEAIYYVSE 194
|
250 260 270
....*....|....*....|....*....|....*...
gi 672076196 790 QDVRQVLHNLSMWCAQSKVLTYDQAKADSQRAK-KDIR 826
Cdd:PRK00440 195 GDMRKAINALQAAAATGKEVTEEAVYKITGTARpEEIR 232
|
|
| PRK13342 |
PRK13342 |
recombination factor protein RarA; Reviewed |
570-679 |
2.72e-08 |
|
recombination factor protein RarA; Reviewed
Pssm-ID: 237355 [Multi-domain] Cd Length: 413 Bit Score: 57.40 E-value: 2.72e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 570 DKYKPTSLKNIIGQQ---GdqscANKLLRWLrnwhksspeekkhakfgkVASKDDGSSfkaaLLSGPPGVGKTTTASLVC 646
Cdd:PRK13342 4 ERMRPKTLDEVVGQEhllG----PGKPLRRM------------------IEAGRLSSM----ILWGPPGTGKTTLARIIA 57
|
90 100 110
....*....|....*....|....*....|...
gi 672076196 647 QELGYSYVELNASDTrSKNSLKAIVAESLNNTS 679
Cdd:PRK13342 58 GATDAPFEALSAVTS-GVKDLREVIEEARQRRS 89
|
|
| 44 |
PHA02544 |
clamp loader, small subunit; Provisional |
566-743 |
1.29e-07 |
|
clamp loader, small subunit; Provisional
Pssm-ID: 222866 [Multi-domain] Cd Length: 316 Bit Score: 54.61 E-value: 1.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 566 LLWVDKYKPTSLKNIIGQQGDqscankllrwlrnwhksspeekkHAKFGKVASKddGSSFKAALLSGPPGVGKTTTASLV 645
Cdd:PHA02544 9 FMWEQKYRPSTIDECILPAAD-----------------------KETFKSIVKK--GRIPNMLLHSPSPGTGKTTVAKAL 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 646 CQELGYSYVELNASDTR---SKNSLKAivaeslnntsikgfYTSGAspSVSARH-ALIMDEVD--GMAGNED--RGGIQE 717
Cdd:PHA02544 64 CNEVGAEVLFVNGSDCRidfVRNRLTR--------------FASTV--SLTGGGkVIIIDEFDrlGLADAQRhlRSFMEA 127
|
170 180
....*....|....*....|....*...
gi 672076196 718 LiglikHTKIPIICMCNDRN--HPKIRS 743
Cdd:PHA02544 128 Y-----SKNCSFIITANNKNgiIEPLRS 150
|
|
| BRCT_PARP1 |
cd17747 |
BRCT domain of poly [ADP-ribose] polymerase 1 (PARP-1) and similar proteins; PARP-1 (EC 2.4.2. ... |
402-474 |
4.25e-07 |
|
BRCT domain of poly [ADP-ribose] polymerase 1 (PARP-1) and similar proteins; PARP-1 (EC 2.4.2.30), also termed ADP-ribosyltransferase diphtheria toxin-like 1 (ARTD1), or NAD(+) ADP-ribosyltransferase 1 (ADPRT 1), or poly[ADP-ribose] synthase 1, is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism.
Pssm-ID: 349378 [Multi-domain] Cd Length: 76 Bit Score: 48.30 E-value: 4.25e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 672076196 402 LEGLTFVITGVLeSIEREEAKSLIERYGGKVTGNVSKKTSYLV---MGRDSGQSKSDKAAALGTKILDEDGLLDLI 474
Cdd:cd17747 1 LTGMKFALIGKL-SKSKDELKKLIEKLGGKVASKVTKKVTLCIstkAEVEKMSKKMKEAKEAGVPVVSEDFLEDCI 75
|
|
| SpoVK |
COG0464 |
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ... |
592-714 |
5.01e-07 |
|
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 440232 [Multi-domain] Cd Length: 397 Bit Score: 53.38 E-value: 5.01e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 592 KLLRWLRNWHKSSPEEKKHAKFGKVaskddgssfKAALLSGPPGVGKTTTASLVCQELGYSYVELNASDTRSK------N 665
Cdd:COG0464 167 EELRELVALPLKRPELREEYGLPPP---------RGLLLYGPPGTGKTLLARALAGELGLPLIEVDLSDLVSKyvgeteK 237
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 672076196 666 SLKAIVAESLnntsikgfytsGASPSVsarhaLIMDEVDGMAGNEDRGG 714
Cdd:COG0464 238 NLREVFDKAR-----------GLAPCV-----LFIDEADALAGKRGEVG 270
|
|
| HolB |
COG0470 |
DNA polymerase III, delta prime subunit [Replication, recombination and repair]; |
627-802 |
6.15e-07 |
|
DNA polymerase III, delta prime subunit [Replication, recombination and repair];
Pssm-ID: 440238 [Multi-domain] Cd Length: 289 Bit Score: 52.28 E-value: 6.15e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 627 AALLSGPPGVGKTTTA-----SLVCQELGYS------------------YVELNA---SDTRSKNSLKAIVaESLNNTSI 680
Cdd:COG0470 20 ALLLHGPPGIGKTTLAlalarDLLCENPEGGkacgqchsrlmaagnhpdLLELNPeekSDQIGIDQIRELG-EFLSLTPL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 681 KGfytsgaspsvsARHALIMDEVDGMAGNEDRGGIQELIGLIKHTkiPIICMCNDRNH--PKIRSLvhyCFDLRFQRPRV 758
Cdd:COG0470 99 EG-----------GRKVVIIDEADAMNEAAANALLKTLEEPPKNT--PFILIANDPSRllPTIRSR---CQVIRFRPPSE 162
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 672076196 759 EQIKSAMlsiafkEGLKIPPPAMNEIILGANQDVRQVLHNLSMW 802
Cdd:COG0470 163 EEALAWL------REEGVDEDALEAILRLAGGDPRAAINLLQAL 200
|
|
| RarA |
COG2256 |
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ... |
574-673 |
3.55e-06 |
|
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair];
Pssm-ID: 441857 [Multi-domain] Cd Length: 439 Bit Score: 50.82 E-value: 3.55e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 574 PTSLKNIIGQQgdqscanKLL---RWLRNWHKSspeekkhakfGKVASkddgssfkaALLSGPPGVGKTTTASLVCQELG 650
Cdd:COG2256 21 PRTLDEVVGQE-------HLLgpgKPLRRAIEA----------GRLSS---------MILWGPPGTGKTTLARLIANATD 74
|
90 100
....*....|....*....|...
gi 672076196 651 YSYVELNASDTrSKNSLKAIVAE 673
Cdd:COG2256 75 AEFVALSAVTS-GVKDIREVIEE 96
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
19-564 |
6.07e-06 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 50.91 E-value: 6.07e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 19 ETVKKNEKTKPSEGtvKGKKGVKEAKVNNPCKEDASRPKQHNKKKRIIYDSDSESEETVQVKNAKKKSEKLpvsckpgki 98
Cdd:PTZ00121 1227 EAVKKAEEAKKDAE--EAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEA--------- 1295
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 99 sRKdpvtyiSETDEDDDFLCKKAASKSKengvstnsylgASNVKKNEENTKTKSKPLSPiKLTPTSVLDYFGTESVQRSG 178
Cdd:PTZ00121 1296 -KK------AEEKKKADEAKKKAEEAKK-----------ADEAKKKAEEAKKKADAAKK-KAEEAKKAAEAAKAEAEAAA 1356
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 179 KKMVASKKKESS---QTPDDSRLNDEAIAKQLQLDEDAELERQLHEDEEFARTLALLDEEPK-TKKARKDSEEGESfspa 254
Cdd:PTZ00121 1357 DEAEAAEEKAEAaekKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKkADEAKKKAEEKKK---- 1432
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 255 KAELSKAAKQKSPANEhfsigrktySPAKYGKGRGSEGTKqpcRSAHQKEACSSLKassKLALMKAQEENSYKETELLAA 334
Cdd:PTZ00121 1433 ADEAKKKAEEAKKADE---------AKKKAEEAKKAEEAK---KKAEEAKKADEAK---KKAEEAKKADEAKKKAEEAKK 1497
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 335 KRESAIEPKGEKTTPRKTKGSPTKRESVSPEDSEKKRTNYQAYRSYLNREGPKALGSKEIPKGAEnclegltfviTGVLE 414
Cdd:PTZ00121 1498 KADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEE----------KKKAE 1567
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 415 SIEREEAKSLIERYGGKVTGNVSKKTSYLVMgRDSGQSKSDKAAALgTKILDEDGLLDLIRTMPGKKSKYEIAAEAEmKK 494
Cdd:PTZ00121 1568 EAKKAEEDKNMALRKAEEAKKAEEARIEEVM-KLYEEEKKMKAEEA-KKAEEAKIKAEELKKAEEEKKKVEQLKKKE-AE 1644
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 495 EKSKLERTPQKNDQGKRKLSPTKRELEPKKSKLTPLKHSPRKAVKEEERVCPRGLDAKEPHGSHSASREE 564
Cdd:PTZ00121 1645 EKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEE 1714
|
|
| RecA-like_protease |
cd19481 |
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ... |
626-734 |
6.73e-06 |
|
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.
Pssm-ID: 410889 [Multi-domain] Cd Length: 158 Bit Score: 47.28 E-value: 6.73e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 626 KAALLSGPPGVGKTTTASLVCQELGYSYVELNASDTRSKNS------LKAI--VAESLnntsikgfytsgaSPSVsarha 697
Cdd:cd19481 27 KGILLYGPPGTGKTLLAKALAGELGLPLIVVKLSSLLSKYVgeseknLRKIfeRARRL-------------APCI----- 88
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 672076196 698 LIMDEVDGMAGNEDRGG------------IQELIGLIKHTKIPIICMCN 734
Cdd:cd19481 89 LFIDEIDAIGRKRDSSGesgelrrvlnqlLTELDGVNSRSKVLVIAATN 137
|
|
| BRCT_TopBP1_rpt2_like |
cd17731 |
second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ... |
402-475 |
1.13e-05 |
|
second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the second BRCT domain.
Pssm-ID: 349363 [Multi-domain] Cd Length: 77 Bit Score: 44.45 E-value: 1.13e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 672076196 402 LEGLTFVITGvLESIEREEAKSLIERYGGKVTGNVSKKTSYLVMGRDSGQsKSDKAAALGT-KILDEDGLLDLIR 475
Cdd:cd17731 3 FKGLVICVTG-FDSEERKEIQQLVEQNGGSYSPDLSKNCTHLIAGSPSGQ-KYEFARKWNSiHIVTPEWLYDSIE 75
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
25-612 |
5.36e-05 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 47.83 E-value: 5.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 25 EKTKPSEGTVKGKKGVKEAKVNNPCKEDASRPKQHNKKKRiiyDSDSESEETVQVKNAKKKSE-KLPVSCKPGKISRK-D 102
Cdd:PTZ00121 1085 EDNRADEATEEAFGKAEEAKKTETGKAEEARKAEEAKKKA---EDARKAEEARKAEDARKAEEaRKAEDAKRVEIARKaE 1161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 103 PVTYISETDEDDDFLCKKAASKSKEngvstnsYLGASNVKKNEENTKTKSKPLSPIKLTPTSVLDYFGTESVQRSGKKMV 182
Cdd:PTZ00121 1162 DARKAEEARKAEDAKKAEAARKAEE-------VRKAEELRKAEDARKAEAARKAEEERKAEEARKAEDAKKAEAVKKAEE 1234
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 183 ASKKKESSQTPDDSRlNDEAIAKQLQLDEDAELERQLHEDEEFARTlalLDEEPKTKKARKDSEEGESFSPAKA-ELSKA 261
Cdd:PTZ00121 1235 AKKDAEEAKKAEEER-NNEEIRKFEEARMAHFARRQAAIKAEEARK---ADELKKAEEKKKADEAKKAEEKKKAdEAKKK 1310
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 262 AKQKSPANEHFSIGRKTYSPAKYGKGRGSEGTKQ-PCRSAHQKEACSSLKASSKLAlmKAQEENSYKETELLAAKRESAI 340
Cdd:PTZ00121 1311 AEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAaEAAKAEAEAAADEAEAAEEKA--EAAEKKKEEAKKKADAAKKKAE 1388
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 341 EPKGEKTTPRKTKGSPTKRESVSPEDSEKKRTNYQAYRSYLNREGPKALGSKEIPKGAENCLEgltfvitgvlESIEREE 420
Cdd:PTZ00121 1389 EKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKK----------KAEEAKK 1458
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 421 AKSLIERYGGKVTGNVSKKTSylvmgrdsgqSKSDKAAALGTKILDEDGLLDLIRTMPGKKSKYEIAAEAEMKKEKSKLE 500
Cdd:PTZ00121 1459 AEEAKKKAEEAKKADEAKKKA----------EEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAK 1528
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 501 RTPQKNDQGK-RKLSPTKRELEPKKSKLTPLKHSPRKA---VKEEERVCPRGLDAKEPHGSHSASREECLLWVDKYKPTS 576
Cdd:PTZ00121 1529 KAEEAKKADEaKKAEEKKKADELKKAEELKKAEEKKKAeeaKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMK 1608
|
570 580 590 600
....*....|....*....|....*....|....*....|..
gi 672076196 577 LKNIIGQQGDQSCANKL------LRWLRNWHKSSPEEKKHAK 612
Cdd:PTZ00121 1609 AEEAKKAEEAKIKAEELkkaeeeKKKVEQLKKKEAEEKKKAE 1650
|
|
| rad24 |
TIGR00602 |
checkpoint protein rad24; All proteins in this family for which functions are known are ... |
531-655 |
2.95e-04 |
|
checkpoint protein rad24; All proteins in this family for which functions are known are involved in DNA damage tolerance (likely cell cycle checkpoints).This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 129690 [Multi-domain] Cd Length: 637 Bit Score: 44.95 E-value: 2.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 531 KHSPRKAVKEEERvcpRGLDAKEPHGSHSASREEC--LLWVDKYKPTSlkniigqQGDQSCANKLLRWLRNWHKS-SPEE 607
Cdd:TIGR00602 38 KNSPSTDIHARKR---GFLSLEQDTGLELSSENLDgnEPWVEKYKPET-------QHELAVHKKKIEEVETWLKAqVLEN 107
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 672076196 608 KKHakfgkvaskddgssfKAALLSGPPGVGKTTTASLVCQELGYSYVE 655
Cdd:TIGR00602 108 APK---------------RILLITGPSGCGKSTTIKILSKELGIQVQE 140
|
|
| PRK14970 |
PRK14970 |
DNA polymerase III subunits gamma and tau; Provisional |
571-814 |
2.96e-04 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 184934 [Multi-domain] Cd Length: 367 Bit Score: 44.48 E-value: 2.96e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 571 KYKPTSLKNIIGQQgdqSCANKLLRWLRNWHKSSpeekkhakfgkvaskddgssfkAALLSGPPGVGKTTTASLVCQEL- 649
Cdd:PRK14970 10 KYRPQTFDDVVGQS---HITNTLLNAIENNHLAQ----------------------ALLFCGPRGVGKTTCARILARKIn 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 650 --GYSYVELNAS------DTRSKNSLkaivaESLNNTSIKGFYtsgaSPSVSARHALIMDEVDGMAGNEDRGGIQELIGL 721
Cdd:PRK14970 65 qpGYDDPNEDFSfnifelDAASNNSV-----DDIRNLIDQVRI----PPQTGKYKIYIIDEVHMLSSAAFNAFLKTLEEP 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 722 IKHTkipIICMCNDRNHPKIRSLVHYCFDLRFQRPRVEQIKSAMLSIAFKEGLKIPPPAMNEIIL---GANQDVRQVLHN 798
Cdd:PRK14970 136 PAHA---IFILATTEKHKIIPTILSRCQIFDFKRITIKDIKEHLAGIAVKEGIKFEDDALHIIAQkadGALRDALSIFDR 212
|
250
....*....|....*.
gi 672076196 799 LSMWCaqSKVLTYDQA 814
Cdd:PRK14970 213 VVTFC--GKNITRQAV 226
|
|
| COG1223 |
COG1223 |
Predicted ATPase, AAA+ superfamily [General function prediction only]; |
577-659 |
3.17e-04 |
|
Predicted ATPase, AAA+ superfamily [General function prediction only];
Pssm-ID: 440836 [Multi-domain] Cd Length: 246 Bit Score: 43.72 E-value: 3.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 577 LKNIIGQQgdqSCANKLLRWLRNWHKSspeeKKHAKFGKVASKDdgssfkaALLSGPPGVGKTTTASLVCQELGYSYVEL 656
Cdd:COG1223 1 LDDVVGQE---EAKKKLKLIIKELRRR----ENLRKFGLWPPRK-------ILFYGPPGTGKTMLAEALAGELKLPLLTV 66
|
...
gi 672076196 657 NAS 659
Cdd:COG1223 67 RLD 69
|
|
| PRK06063 |
PRK06063 |
DEDDh family exonuclease; |
415-479 |
4.43e-04 |
|
DEDDh family exonuclease;
Pssm-ID: 180377 [Multi-domain] Cd Length: 313 Bit Score: 43.54 E-value: 4.43e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 672076196 415 SIEREEaksLIERY---GGKVTGNVSKKTSYLVMGR-DSGQSKSDKAAALGTKILDEDGLLDLIRTMPG 479
Cdd:PRK06063 245 SRTHEE---LVERIlhaGLAYSDSVDRDTSLVVCNDpAPEQGKGYHARQLGVPVLDEAAFLELLRAVVG 310
|
|
| ruvB |
TIGR00635 |
Holliday junction DNA helicase, RuvB subunit; All proteins in this family for which functions ... |
617-650 |
4.47e-04 |
|
Holliday junction DNA helicase, RuvB subunit; All proteins in this family for which functions are known are 5'-3' DNA helicases that, as part of a complex with RuvA homologs serve as a 5'-3' Holliday junction helicase. RuvA specifically binds Holliday junctions as a sandwich of two tetramers and maintains the configuration of the junction. It forms a complex with two hexameric rings of RuvB, the subunit that contains helicase activity. The complex drives ATP-dependent branch migration of the Holliday junction recombination intermediate. The endonuclease RuvC resolves junctions. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 129721 [Multi-domain] Cd Length: 305 Bit Score: 43.83 E-value: 4.47e-04
10 20 30
....*....|....*....|....*....|....
gi 672076196 617 ASKDDGSSFKAALLSGPPGVGKTTTASLVCQELG 650
Cdd:TIGR00635 22 AAKMRQEALDHLLLYGPPGLGKTTLAHIIANEMG 55
|
|
| Fap7 |
COG1936 |
Broad-specificity NMP kinase [Nucleotide transport and metabolism]; |
629-657 |
1.29e-03 |
|
Broad-specificity NMP kinase [Nucleotide transport and metabolism];
Pssm-ID: 441539 [Multi-domain] Cd Length: 173 Bit Score: 40.95 E-value: 1.29e-03
10 20
....*....|....*....|....*....
gi 672076196 629 LLSGPPGVGKTTTASLVCQELGYSYVELN 657
Cdd:COG1936 4 AITGTPGTGKTTVAKLLAERLGLEVIHLN 32
|
|
| CMPK |
cd02020 |
Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine ... |
630-654 |
1.55e-03 |
|
Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor.
Pssm-ID: 238978 [Multi-domain] Cd Length: 147 Bit Score: 40.16 E-value: 1.55e-03
10 20
....*....|....*....|....*
gi 672076196 630 LSGPPGVGKTTTASLVCQELGYSYV 654
Cdd:cd02020 4 IDGPAGSGKSTVAKLLAKKLGLPYL 28
|
|
| Rad17 |
pfam03215 |
Rad17 P-loop domain; |
567-663 |
1.96e-03 |
|
Rad17 P-loop domain;
Pssm-ID: 367398 [Multi-domain] Cd Length: 186 Bit Score: 40.71 E-value: 1.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 567 LWVDKYKPTSLKNIIgqqgdqscankllrwlrnWHKSSPEEKKHAKFGKVASKDDGSSFkaaLLSGPPGVGKTTTASLVC 646
Cdd:pfam03215 8 QWYEKYKPNCLEQLA------------------VHKRKIKDVQEWLDAMFLENAKHRIL---LISGPSGCGKSTVIKELS 66
|
90
....*....|....*...
gi 672076196 647 QELGYSYVE-LNASDTRS 663
Cdd:pfam03215 67 KELGPKYREwSNPTSFRS 84
|
|
| CDC6 |
COG1474 |
Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]; |
628-773 |
2.03e-03 |
|
Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];
Pssm-ID: 441083 [Multi-domain] Cd Length: 389 Bit Score: 41.76 E-value: 2.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 628 ALLSGPPGVGKTTTASLVCQELGY---------SYVELNASDTRSKNSLKAIVAESLNNTsiKGFYTSGASPSV------ 692
Cdd:COG1474 54 VLIYGPTGTGKTAVAKYVLEELEEeaeergvdvRVVYVNCRQASTRYRVLSRILEELGSG--EDIPSTGLSTDElfdrly 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 693 ------SARHALIMDEVDGMAGNEDRGGIQELIGL---IKHTKIPIICMCND---RNH--PKIRSlVHYCFDLRFQRPRV 758
Cdd:COG1474 132 ealderDGVLVVVLDEIDYLVDDEGDDLLYQLLRAneeLEGARVGVIGISNDlefLENldPRVKS-SLGEEEIVFPPYDA 210
|
170
....*....|....*...
gi 672076196 759 EQIKSAML---SIAFKEG 773
Cdd:COG1474 211 DELRDILEdraELAFYDG 228
|
|
| RuvB_N |
pfam05496 |
Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the ... |
629-650 |
2.09e-03 |
|
Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the RuvABC revolvasome which catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. Branch migration is catalyzed by the RuvB protein that is targeted to the Holliday junction by the structure specific RuvA protein. This family contains the N-terminal region of the protein.
Pssm-ID: 398900 [Multi-domain] Cd Length: 159 Bit Score: 40.18 E-value: 2.09e-03
|
| RPT1 |
COG1222 |
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ... |
626-664 |
3.47e-03 |
|
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440835 [Multi-domain] Cd Length: 326 Bit Score: 40.76 E-value: 3.47e-03
10 20 30
....*....|....*....|....*....|....*....
gi 672076196 626 KAALLSGPPGVGKTTTASLVCQELGYSYVELNASDTRSK 664
Cdd:COG1222 113 KGVLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSELVSK 151
|
|
| RuvB |
COG2255 |
Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB [Replication, ... |
629-650 |
3.82e-03 |
|
Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB [Replication, recombination and repair];
Pssm-ID: 441856 [Multi-domain] Cd Length: 337 Bit Score: 40.83 E-value: 3.82e-03
|
| ruvB |
PRK00080 |
Holliday junction branch migration DNA helicase RuvB; |
629-650 |
4.85e-03 |
|
Holliday junction branch migration DNA helicase RuvB;
Pssm-ID: 234619 [Multi-domain] Cd Length: 328 Bit Score: 40.50 E-value: 4.85e-03
|
| AAA_17 |
pfam13207 |
AAA domain; |
631-660 |
4.95e-03 |
|
AAA domain;
Pssm-ID: 463810 [Multi-domain] Cd Length: 136 Bit Score: 38.37 E-value: 4.95e-03
10 20 30
....*....|....*....|....*....|
gi 672076196 631 SGPPGVGKTTTASLVCQELGYSYVelNASD 660
Cdd:pfam13207 1 TGVPGSGKTTQLKKLAEKLGFPHI--SAGD 28
|
|
| RecA-like_CDC48_NLV2_r1-like |
cd19503 |
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ... |
626-707 |
5.10e-03 |
|
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.
Pssm-ID: 410911 [Multi-domain] Cd Length: 165 Bit Score: 39.20 E-value: 5.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 626 KAALLSGPPGVGKTTTASLVCQELGYSYVELNASDTRSK------NSLKAIVAESlnntsikgfytSGASPSVsarhaLI 699
Cdd:cd19503 35 RGVLLHGPPGTGKTLLARAVANEAGANFLSISGPSIVSKylgeseKNLREIFEEA-----------RSHAPSI-----IF 98
|
....*...
gi 672076196 700 MDEVDGMA 707
Cdd:cd19503 99 IDEIDALA 106
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
19-544 |
5.27e-03 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 41.28 E-value: 5.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 19 ETVKKNEKTKPSEGTVKG---KKGVKEAKVNNPCKEDASRPKQHNKKKRII--YDSDSESEETVQVKNAKKKSEKlpvsC 93
Cdd:PTZ00121 1167 EEARKAEDAKKAEAARKAeevRKAEELRKAEDARKAEAARKAEEERKAEEArkAEDAKKAEAVKKAEEAKKDAEE----A 1242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 94 KPGKISRKDPVTYISETDEDDDFLCKKAASKSKENgvstnsyLGASNVKKNEENTKTkskplspikltptsvldyfgtES 173
Cdd:PTZ00121 1243 KKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEA-------RKADELKKAEEKKKA---------------------DE 1294
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 174 VQRSGKKmvaSKKKESSQTPDDSRLNDEAIAKQLQLDEDAELERQLHEDEEFARTLALLDEEPKTKKARKDSEEGESFSP 253
Cdd:PTZ00121 1295 AKKAEEK---KKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEK 1371
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 254 AKAELSKAAKQKSPANEHFSIGRKTYSPAKYGKGRGSEGTKQPCRSAHQKEACSSLKASSKL--ALMKAQEENSYKETEL 331
Cdd:PTZ00121 1372 KKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKAdeAKKKAEEAKKADEAKK 1451
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 332 LAAKRESAIEPKGEKTTPRKTKGSPTKRESVSPEDSEKKRTNYQAYRSYLNREGPKALGSKEIPKGAEnclegltfvitg 411
Cdd:PTZ00121 1452 KAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAE------------ 1519
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 412 vlESIEREEAKSLIE-RYGGKVTGNVSKKTSYLVMGRDSGQSKSDKAAALGTKILDEDGLLDLIRTMPGKKSKYEIAAEA 490
Cdd:PTZ00121 1520 --EAKKADEAKKAEEaKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEV 1597
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*.
gi 672076196 491 EMKKEKSKLERTPQ--KNDQGKRKLSPTKRELEPKKsKLTPLKHSPRKAVKEEERV 544
Cdd:PTZ00121 1598 MKLYEEEKKMKAEEakKAEEAKIKAEELKKAEEEKK-KVEQLKKKEAEEKKKAEEL 1652
|
|
| RecA-like_CDC48_r2-like |
cd19511 |
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ... |
626-717 |
5.60e-03 |
|
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.
Pssm-ID: 410919 [Multi-domain] Cd Length: 159 Bit Score: 38.80 E-value: 5.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672076196 626 KAALLSGPPGVGKTTTASLVCQELGYSYVELNASDTRSKnslkaIVAESLNNTSiKGFYTS-GASPSVsarhaLIMDEVD 704
Cdd:cd19511 28 KGVLLYGPPGCGKTLLAKALASEAGLNFISVKGPELFSK-----YVGESERAVR-EIFQKArQAAPCI-----IFFDEID 96
|
90
....*....|....*.
gi 672076196 705 GMA---GNEDRGGIQE 717
Cdd:cd19511 97 SLAprrGQSDSSGVTD 112
|
|
| |
