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Conserved domains on  [gi|672078644|ref|XP_008769062|]
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WW domain-binding protein 4 isoform X1 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRP40 super family cl34905
Splicing factor [RNA processing and modification];
138-206 1.01e-10

Splicing factor [RNA processing and modification];


The actual alignment was detected with superfamily member COG5104:

Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 63.18  E-value: 1.01e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 672078644 138 WVEGVTADGHCYYYDLVTGASQWEKPEGFQGNLKKTAAKAIWVEGLSEDGYTYYYNTETGESKWEKPDD 206
Cdd:COG5104   17 WEELKAPDGRIYYYNKRTGKSSWEKPKELLKGSEEDLDVDPWKECRTADGKVYYYNSITRESRWKIPPE 85
 
Name Accession Description Interval E-value
PRP40 COG5104
Splicing factor [RNA processing and modification];
138-206 1.01e-10

Splicing factor [RNA processing and modification];


Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 63.18  E-value: 1.01e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 672078644 138 WVEGVTADGHCYYYDLVTGASQWEKPEGFQGNLKKTAAKAIWVEGLSEDGYTYYYNTETGESKWEKPDD 206
Cdd:COG5104   17 WEELKAPDGRIYYYNKRTGKSSWEKPKELLKGSEEDLDVDPWKECRTADGKVYYYNSITRESRWKIPPE 85
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 179-204 2.39e-08

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 49.43  E-value: 2.39e-08
                          10        20
                  ....*....|....*....|....*.
gi 672078644  179 WVEGLSEDGYTYYYNTETGESKWEKP 204
Cdd:pfam00397   5 WEERWDPDGRVYYYNHETGETQWEKP 30
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 179-206 6.11e-08

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 48.29  E-value: 6.11e-08
                         10        20
                 ....*....|....*....|....*...
gi 672078644 179 WVEGLSEDGYTYYYNTETGESKWEKPDD 206
Cdd:cd00201    4 WEERWDPDGRVYYYNHNTKETQWEDPRE 31
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 179-206 1.55e-07

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 47.21  E-value: 1.55e-07
                           10        20
                   ....*....|....*....|....*...
gi 672078644   179 WVEGLSEDGYTYYYNTETGESKWEKPDD 206
Cdd:smart00456   6 WEERKDPDGRPYYYNHETKETQWEKPRE 33
 
Name Accession Description Interval E-value
PRP40 COG5104
Splicing factor [RNA processing and modification];
138-206 1.01e-10

Splicing factor [RNA processing and modification];


Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 63.18  E-value: 1.01e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 672078644 138 WVEGVTADGHCYYYDLVTGASQWEKPEGFQGNLKKTAAKAIWVEGLSEDGYTYYYNTETGESKWEKPDD 206
Cdd:COG5104   17 WEELKAPDGRIYYYNKRTGKSSWEKPKELLKGSEEDLDVDPWKECRTADGKVYYYNSITRESRWKIPPE 85
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 179-204 2.39e-08

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 49.43  E-value: 2.39e-08
                          10        20
                  ....*....|....*....|....*.
gi 672078644  179 WVEGLSEDGYTYYYNTETGESKWEKP 204
Cdd:pfam00397   5 WEERWDPDGRVYYYNHETGETQWEKP 30
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 179-206 6.11e-08

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 48.29  E-value: 6.11e-08
                         10        20
                 ....*....|....*....|....*...
gi 672078644 179 WVEGLSEDGYTYYYNTETGESKWEKPDD 206
Cdd:cd00201    4 WEERWDPDGRVYYYNHNTKETQWEDPRE 31
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 179-206 1.55e-07

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 47.21  E-value: 1.55e-07
                           10        20
                   ....*....|....*....|....*...
gi 672078644   179 WVEGLSEDGYTYYYNTETGESKWEKPDD 206
Cdd:smart00456   6 WEERKDPDGRPYYYNHETKETQWEKPRE 33
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 138-163 5.27e-07

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 45.57  E-value: 5.27e-07
                          10        20
                  ....*....|....*....|....*.
gi 672078644  138 WVEGVTADGHCYYYDLVTGASQWEKP 163
Cdd:pfam00397   5 WEERWDPDGRVYYYNHETGETQWEKP 30
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 138-165 1.34e-06

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 44.44  E-value: 1.34e-06
                         10        20
                 ....*....|....*....|....*...
gi 672078644 138 WVEGVTADGHCYYYDLVTGASQWEKPEG 165
Cdd:cd00201    4 WEERWDPDGRVYYYNHNTKETQWEDPRE 31
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 138-165 4.47e-06

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 42.97  E-value: 4.47e-06
                           10        20
                   ....*....|....*....|....*...
gi 672078644   138 WVEGVTADGHCYYYDLVTGASQWEKPEG 165
Cdd:smart00456   6 WEERKDPDGRPYYYNHETKETQWEKPRE 33
PRP40 COG5104
Splicing factor [RNA processing and modification];
164-208 8.13e-05

Splicing factor [RNA processing and modification];


Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 44.69  E-value: 8.13e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 672078644 164 EGFQGNLKKTAAkAIWVEGLSEDGYTYYYNTETGESKWEKPDDFI 208
Cdd:COG5104    3 AALLGMASGEAR-SEWEELKAPDGRIYYYNKRTGKSSWEKPKELL 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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