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Conserved domains on  [gi|672082545|ref|XP_008770120|]
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proline and serine-rich protein 2 isoform X1 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SARG super family cl25900
Specifically androgen-regulated gene protein; This family of proteins is found in eukaryotes, ...
 439-469 3.88e-06

Specifically androgen-regulated gene protein; This family of proteins is found in eukaryotes, the function of this protein is still unknown but it is thought to be an androgen receptor. Protein expression is up-regulated in the presence of androgens, but not in the presence of glucocorticoids. SARG tends to be highly expressed in prostate tissue. Proteins in this family are typically between 340 and 587 amino acids in length. There is a conserved EETI sequence motif.


The actual alignment was detected with superfamily member pfam15385:

Pssm-ID: 464692 [Multi-domain]  Cd Length: 568  Bit Score: 49.40  E-value: 3.88e-06
                          10        20        30
                  ....*....|....*....|....*....|.
gi 672082545  439 RPQGITVQFSGRGSTEEARREALRKLGLLKE 469
Cdd:pfam15385 538 RPPCVSVKISPKGVPDEHRREALKKLGLLKE 568
SARG super family cl25900
Specifically androgen-regulated gene protein; This family of proteins is found in eukaryotes, ...
 46-268 3.05e-04

Specifically androgen-regulated gene protein; This family of proteins is found in eukaryotes, the function of this protein is still unknown but it is thought to be an androgen receptor. Protein expression is up-regulated in the presence of androgens, but not in the presence of glucocorticoids. SARG tends to be highly expressed in prostate tissue. Proteins in this family are typically between 340 and 587 amino acids in length. There is a conserved EETI sequence motif.


The actual alignment was detected with superfamily member pfam15385:

Pssm-ID: 464692 [Multi-domain]  Cd Length: 568  Bit Score: 43.24  E-value: 3.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672082545   46 MDDESLKHLTHEEKDVILFFEETLDSLEYDFDEPTLCDSGIHCHSPQSLEESPSSH----SEPEDVIDLVQPAPASGEAE 121
Cdd:pfam15385   3 SSDSSYDFLSAEEKECLLFLEETIGSLDTEADSGLSTDESEPATTPRSPRALPITQpapqGLPEETIIQQRPEPRRVTQS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672082545  122 SLPDVP-PVAGSPSVAKQSTP--FLEGGKQATENSLPPPDSRGPEV----LPLP-------SSLPISAPSAPQK---EL- 183
Cdd:pfam15385  83 SSTHPPePQGLGLRSGSYSLPrnIHIGRSQNLRKSTTQTNSHIPGEseglVPEPekeqtsqSSEPSQPPATPQEaalDLd 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672082545  184 MSPSPPAE-----------------HPKLPRSVP--TPLVIAQKISEklGGNEALSPTSPSKES--RPGEWRTPTSLASR 242
Cdd:pfam15385 163 TVLIPPPEafrdtqpeqrgedslpkGPGQQSPTPqlHPSVSSQKRKE--TSSEAMSQKAKEKGStgGPGQPQPPPAMSSQ 240

                         250       260       270
                  ....*....|....*....|....*....|....
gi 672082545  243 N---GDHVGMWHRHTAQP-----APKVHRFPSNI 268
Cdd:pfam15385 241 NlrsEDAPLPSGGDPSAKlapptAPKPRKLPPNI 274
 
Name Accession Description Interval E-value
SARG pfam15385
Specifically androgen-regulated gene protein; This family of proteins is found in eukaryotes, ...
 439-469 3.88e-06

Specifically androgen-regulated gene protein; This family of proteins is found in eukaryotes, the function of this protein is still unknown but it is thought to be an androgen receptor. Protein expression is up-regulated in the presence of androgens, but not in the presence of glucocorticoids. SARG tends to be highly expressed in prostate tissue. Proteins in this family are typically between 340 and 587 amino acids in length. There is a conserved EETI sequence motif.


Pssm-ID: 464692 [Multi-domain]  Cd Length: 568  Bit Score: 49.40  E-value: 3.88e-06
                          10        20        30
                  ....*....|....*....|....*....|.
gi 672082545  439 RPQGITVQFSGRGSTEEARREALRKLGLLKE 469
Cdd:pfam15385 538 RPPCVSVKISPKGVPDEHRREALKKLGLLKE 568
SARG pfam15385
Specifically androgen-regulated gene protein; This family of proteins is found in eukaryotes, ...
 46-268 3.05e-04

Specifically androgen-regulated gene protein; This family of proteins is found in eukaryotes, the function of this protein is still unknown but it is thought to be an androgen receptor. Protein expression is up-regulated in the presence of androgens, but not in the presence of glucocorticoids. SARG tends to be highly expressed in prostate tissue. Proteins in this family are typically between 340 and 587 amino acids in length. There is a conserved EETI sequence motif.


Pssm-ID: 464692 [Multi-domain]  Cd Length: 568  Bit Score: 43.24  E-value: 3.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672082545   46 MDDESLKHLTHEEKDVILFFEETLDSLEYDFDEPTLCDSGIHCHSPQSLEESPSSH----SEPEDVIDLVQPAPASGEAE 121
Cdd:pfam15385   3 SSDSSYDFLSAEEKECLLFLEETIGSLDTEADSGLSTDESEPATTPRSPRALPITQpapqGLPEETIIQQRPEPRRVTQS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672082545  122 SLPDVP-PVAGSPSVAKQSTP--FLEGGKQATENSLPPPDSRGPEV----LPLP-------SSLPISAPSAPQK---EL- 183
Cdd:pfam15385  83 SSTHPPePQGLGLRSGSYSLPrnIHIGRSQNLRKSTTQTNSHIPGEseglVPEPekeqtsqSSEPSQPPATPQEaalDLd 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672082545  184 MSPSPPAE-----------------HPKLPRSVP--TPLVIAQKISEklGGNEALSPTSPSKES--RPGEWRTPTSLASR 242
Cdd:pfam15385 163 TVLIPPPEafrdtqpeqrgedslpkGPGQQSPTPqlHPSVSSQKRKE--TSSEAMSQKAKEKGStgGPGQPQPPPAMSSQ 240

                         250       260       270
                  ....*....|....*....|....*....|....
gi 672082545  243 N---GDHVGMWHRHTAQP-----APKVHRFPSNI 268
Cdd:pfam15385 241 NlrsEDAPLPSGGDPSAKlapptAPKPRKLPPNI 274
PLN02217 PLN02217
probable pectinesterase/pectinesterase inhibitor
 105-226 2.12e-03

probable pectinesterase/pectinesterase inhibitor


Pssm-ID: 215130 [Multi-domain]  Cd Length: 670  Bit Score: 40.46  E-value: 2.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672082545 105 EDVIDLVQPAPASGEA----ESLPDVPPV-AGSPSVAKQSTPFLEGGKQATENSLPPPDSRGPEVLPlPSSLPISAPSAP 179
Cdd:PLN02217 533 EEILKFTPAQYIQGDAwipgKGVPYIPGLfAGNPGSTNSTPTGSAASSNTTFSSDSPSTVVAPSTSP-PAGHLGSPPATP 611

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 672082545 180 QKeLMSP--SPPAEHPKLPRSVPTPLVIAQKISeklgGNEALSPTSPSK 226
Cdd:PLN02217 612 SK-IVSPstSPPASHLGSPSTTPSSPESSIKVA----STETASPESSIK 655
 
Name Accession Description Interval E-value
SARG pfam15385
Specifically androgen-regulated gene protein; This family of proteins is found in eukaryotes, ...
 439-469 3.88e-06

Specifically androgen-regulated gene protein; This family of proteins is found in eukaryotes, the function of this protein is still unknown but it is thought to be an androgen receptor. Protein expression is up-regulated in the presence of androgens, but not in the presence of glucocorticoids. SARG tends to be highly expressed in prostate tissue. Proteins in this family are typically between 340 and 587 amino acids in length. There is a conserved EETI sequence motif.


Pssm-ID: 464692 [Multi-domain]  Cd Length: 568  Bit Score: 49.40  E-value: 3.88e-06
                          10        20        30
                  ....*....|....*....|....*....|.
gi 672082545  439 RPQGITVQFSGRGSTEEARREALRKLGLLKE 469
Cdd:pfam15385 538 RPPCVSVKISPKGVPDEHRREALKKLGLLKE 568
SARG pfam15385
Specifically androgen-regulated gene protein; This family of proteins is found in eukaryotes, ...
 46-268 3.05e-04

Specifically androgen-regulated gene protein; This family of proteins is found in eukaryotes, the function of this protein is still unknown but it is thought to be an androgen receptor. Protein expression is up-regulated in the presence of androgens, but not in the presence of glucocorticoids. SARG tends to be highly expressed in prostate tissue. Proteins in this family are typically between 340 and 587 amino acids in length. There is a conserved EETI sequence motif.


Pssm-ID: 464692 [Multi-domain]  Cd Length: 568  Bit Score: 43.24  E-value: 3.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672082545   46 MDDESLKHLTHEEKDVILFFEETLDSLEYDFDEPTLCDSGIHCHSPQSLEESPSSH----SEPEDVIDLVQPAPASGEAE 121
Cdd:pfam15385   3 SSDSSYDFLSAEEKECLLFLEETIGSLDTEADSGLSTDESEPATTPRSPRALPITQpapqGLPEETIIQQRPEPRRVTQS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672082545  122 SLPDVP-PVAGSPSVAKQSTP--FLEGGKQATENSLPPPDSRGPEV----LPLP-------SSLPISAPSAPQK---EL- 183
Cdd:pfam15385  83 SSTHPPePQGLGLRSGSYSLPrnIHIGRSQNLRKSTTQTNSHIPGEseglVPEPekeqtsqSSEPSQPPATPQEaalDLd 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672082545  184 MSPSPPAE-----------------HPKLPRSVP--TPLVIAQKISEklGGNEALSPTSPSKES--RPGEWRTPTSLASR 242
Cdd:pfam15385 163 TVLIPPPEafrdtqpeqrgedslpkGPGQQSPTPqlHPSVSSQKRKE--TSSEAMSQKAKEKGStgGPGQPQPPPAMSSQ 240

                         250       260       270
                  ....*....|....*....|....*....|....
gi 672082545  243 N---GDHVGMWHRHTAQP-----APKVHRFPSNI 268
Cdd:pfam15385 241 NlrsEDAPLPSGGDPSAKlapptAPKPRKLPPNI 274
PLN02217 PLN02217
probable pectinesterase/pectinesterase inhibitor
 105-226 2.12e-03

probable pectinesterase/pectinesterase inhibitor


Pssm-ID: 215130 [Multi-domain]  Cd Length: 670  Bit Score: 40.46  E-value: 2.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672082545 105 EDVIDLVQPAPASGEA----ESLPDVPPV-AGSPSVAKQSTPFLEGGKQATENSLPPPDSRGPEVLPlPSSLPISAPSAP 179
Cdd:PLN02217 533 EEILKFTPAQYIQGDAwipgKGVPYIPGLfAGNPGSTNSTPTGSAASSNTTFSSDSPSTVVAPSTSP-PAGHLGSPPATP 611

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 672082545 180 QKeLMSP--SPPAEHPKLPRSVPTPLVIAQKISeklgGNEALSPTSPSK 226
Cdd:PLN02217 612 SK-IVSPstSPPASHLGSPSTTPSSPESSIKVA----STETASPESSIK 655
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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