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Conserved domains on  [gi|755496800|ref|XP_011237278|]
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proline and serine-rich protein 2 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SARG super family cl25900
Specifically androgen-regulated gene protein; This family of proteins is found in eukaryotes, ...
 439-469 3.55e-06

Specifically androgen-regulated gene protein; This family of proteins is found in eukaryotes, the function of this protein is still unknown but it is thought to be an androgen receptor. Protein expression is up-regulated in the presence of androgens, but not in the presence of glucocorticoids. SARG tends to be highly expressed in prostate tissue. Proteins in this family are typically between 340 and 587 amino acids in length. There is a conserved EETI sequence motif.


The actual alignment was detected with superfamily member pfam15385:

Pssm-ID: 464692 [Multi-domain]  Cd Length: 568  Bit Score: 49.40  E-value: 3.55e-06
                          10        20        30
                  ....*....|....*....|....*....|.
gi 755496800  439 RPQGITVQFSGRGSTEEARREALRKLGLLKE 469
Cdd:pfam15385 538 RPPCVSVKISPKGVPDEHRREALKKLGLLKE 568
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 97-261 9.43e-03

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 38.77  E-value: 9.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496800   97 SPSSHSEPEDVIDLVQPAPASGE-AESLPDMPQVTGAPSDTKHGTPFLEGGKQAAENSLP------PPDSRGPEVFPLPP 169
Cdd:PHA03247 2823 SPAGPLPPPTSAQPTAPPPPPGPpPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPvrrlarPAVSRSTESFALPP 2902

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496800  170 SLPVPAPSAPRKELMSPSPPAEHPKLLRSVPTPLVIAQkiseklagnealSPTSPSKEGRPGEWRTPTSPASRNG----D 245
Cdd:PHA03247 2903 DQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQ------------PPLAPTTDPAGAGEPSGAVPQPWLGalvpG 2970

                         170
                  ....*....|....*.
gi 755496800  246 HVGVWHRHTTQSAPKV 261
Cdd:PHA03247 2971 RVAVPRFRVPQPAPSR 2986
 
Name Accession Description Interval E-value
SARG pfam15385
Specifically androgen-regulated gene protein; This family of proteins is found in eukaryotes, ...
 439-469 3.55e-06

Specifically androgen-regulated gene protein; This family of proteins is found in eukaryotes, the function of this protein is still unknown but it is thought to be an androgen receptor. Protein expression is up-regulated in the presence of androgens, but not in the presence of glucocorticoids. SARG tends to be highly expressed in prostate tissue. Proteins in this family are typically between 340 and 587 amino acids in length. There is a conserved EETI sequence motif.


Pssm-ID: 464692 [Multi-domain]  Cd Length: 568  Bit Score: 49.40  E-value: 3.55e-06
                          10        20        30
                  ....*....|....*....|....*....|.
gi 755496800  439 RPQGITVQFSGRGSTEEARREALRKLGLLKE 469
Cdd:pfam15385 538 RPPCVSVKISPKGVPDEHRREALKKLGLLKE 568
PHA03247 PHA03247
large tegument protein UL36; Provisional
 97-261 9.43e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 38.77  E-value: 9.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496800   97 SPSSHSEPEDVIDLVQPAPASGE-AESLPDMPQVTGAPSDTKHGTPFLEGGKQAAENSLP------PPDSRGPEVFPLPP 169
Cdd:PHA03247 2823 SPAGPLPPPTSAQPTAPPPPPGPpPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPvrrlarPAVSRSTESFALPP 2902

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496800  170 SLPVPAPSAPRKELMSPSPPAEHPKLLRSVPTPLVIAQkiseklagnealSPTSPSKEGRPGEWRTPTSPASRNG----D 245
Cdd:PHA03247 2903 DQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQ------------PPLAPTTDPAGAGEPSGAVPQPWLGalvpG 2970

                         170
                  ....*....|....*.
gi 755496800  246 HVGVWHRHTTQSAPKV 261
Cdd:PHA03247 2971 RVAVPRFRVPQPAPSR 2986
 
Name Accession Description Interval E-value
SARG pfam15385
Specifically androgen-regulated gene protein; This family of proteins is found in eukaryotes, ...
 439-469 3.55e-06

Specifically androgen-regulated gene protein; This family of proteins is found in eukaryotes, the function of this protein is still unknown but it is thought to be an androgen receptor. Protein expression is up-regulated in the presence of androgens, but not in the presence of glucocorticoids. SARG tends to be highly expressed in prostate tissue. Proteins in this family are typically between 340 and 587 amino acids in length. There is a conserved EETI sequence motif.


Pssm-ID: 464692 [Multi-domain]  Cd Length: 568  Bit Score: 49.40  E-value: 3.55e-06
                          10        20        30
                  ....*....|....*....|....*....|.
gi 755496800  439 RPQGITVQFSGRGSTEEARREALRKLGLLKE 469
Cdd:pfam15385 538 RPPCVSVKISPKGVPDEHRREALKKLGLLKE 568
PHA03247 PHA03247
large tegument protein UL36; Provisional
 97-261 9.43e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 38.77  E-value: 9.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496800   97 SPSSHSEPEDVIDLVQPAPASGE-AESLPDMPQVTGAPSDTKHGTPFLEGGKQAAENSLP------PPDSRGPEVFPLPP 169
Cdd:PHA03247 2823 SPAGPLPPPTSAQPTAPPPPPGPpPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPvrrlarPAVSRSTESFALPP 2902

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496800  170 SLPVPAPSAPRKELMSPSPPAEHPKLLRSVPTPLVIAQkiseklagnealSPTSPSKEGRPGEWRTPTSPASRNG----D 245
Cdd:PHA03247 2903 DQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQ------------PPLAPTTDPAGAGEPSGAVPQPWLGalvpG 2970

                         170
                  ....*....|....*.
gi 755496800  246 HVGVWHRHTTQSAPKV 261
Cdd:PHA03247 2971 RVAVPRFRVPQPAPSR 2986
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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