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Conserved domains on  [gi|755496808|ref|XP_011237280|]
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ankyrin repeat domain-containing protein 16 isoform X1 [Mus musculus]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 12790921)

ankyrin repeat (ANK) domain-containing protein mediates specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

CATH:  1.25.40.20
Gene Ontology:  GO:0005515
PubMed:  33435370|15152081|17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
35-258 1.38e-36

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 133.54  E-value: 1.38e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808  35 PAGDTLLHCAARHGRQDILAYLVEAWSMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAVVDSLKKADWTPLMMACTR 114
Cdd:COG0666   51 DALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808 115 KNLDVIQDLVEHGANPLLKNKDGWNSFHIASREGHPVILRYLLT--VCPDAwktESNIRRTPLHTAAMHGCLEAVQVLLE 192
Cdd:COG0666  131 GNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEagADVNA---RDNDGETPLHLAAENGHLEIVKLLLE 207

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755496808 193 RCHyEPDCRDNCGVTPFMDAIQCGHVSIAKLLLEqHKACSSAADSMGAQALHRAAVTGQDEAIRFL 258
Cdd:COG0666  208 AGA-DVNAKDNDGKTALDLAAENGNLEIVKLLLE-AGADLNAKDKDGLTALLLAAAAGAALIVKLL 271
Ank_4 pfam13637
Ankyrin repeats (many copies);
242-294 3.89e-05

Ankyrin repeats (many copies);


:

Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 40.72  E-value: 3.89e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 755496808  242 ALHRAAVTGQDEAIRFLVCgLGIDVDVRAKSSQlTALHYAAKEGQTNTVQTLL 294
Cdd:pfam13637   4 ALHAAAASGHLELLRLLLE-KGADINAVDGNGE-TALHFAASNGNVEVLKLLL 54
Ank_2 super family cl48147
Ankyrin repeats (3 copies);
278-314 1.84e-03

Ankyrin repeats (3 copies);


The actual alignment was detected with superfamily member pfam12796:

Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 37.02  E-value: 1.84e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 755496808  278 LHYAAKEGQTNTVQTLLSLGADINSTDERNRSVPHMC 314
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLA 37
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
35-258 1.38e-36

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 133.54  E-value: 1.38e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808  35 PAGDTLLHCAARHGRQDILAYLVEAWSMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAVVDSLKKADWTPLMMACTR 114
Cdd:COG0666   51 DALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808 115 KNLDVIQDLVEHGANPLLKNKDGWNSFHIASREGHPVILRYLLT--VCPDAwktESNIRRTPLHTAAMHGCLEAVQVLLE 192
Cdd:COG0666  131 GNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEagADVNA---RDNDGETPLHLAAENGHLEIVKLLLE 207

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755496808 193 RCHyEPDCRDNCGVTPFMDAIQCGHVSIAKLLLEqHKACSSAADSMGAQALHRAAVTGQDEAIRFL 258
Cdd:COG0666  208 AGA-DVNAKDNDGKTALDLAAENGNLEIVKLLLE-AGADLNAKDKDGLTALLLAAAAGAALIVKLL 271
Ank_2 pfam12796
Ankyrin repeats (3 copies);
175-304 1.02e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 79.77  E-value: 1.02e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808  175 LHTAAMHGCLEAVQVLLErCHYEPDCRDNCGVTPFMDAIQCGHVSIAKLLLEQhkacssaadsmgaqalhraavtgqdea 254
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLE-NGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH--------------------------- 52

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 755496808  255 irflvcglgidVDVRAKSSQLTALHYAAKEGQTNTVQTLLSLGADINSTD 304
Cdd:pfam12796  53 -----------ADVNLKDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 75-301 4.68e-15

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 75.80  E-value: 4.68e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808  75 LHEAASMGHRDCVRYLLGRGAVVDSLKKADWTPLMMACTRKNLDVIQDLVEHGANPLLKNKDGWNSFHIASREGHPVILR 154
Cdd:PHA02875   6 LCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVE 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808 155 YLL---TVCPDAWKTESNirrTPLHTAAMHGCLEAVQVLLERcHYEPDCRDNCGVTPFMDAIQCGHVSIAKLLLEqHKAC 231
Cdd:PHA02875  86 ELLdlgKFADDVFYKDGM---TPLHLATILKKLDIMKLLIAR-GADPDIPNTDKFSPLHLAVMMGDIKGIELLID-HKAC 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808 232 SSAADSMGAQALHRAAVTGQDEAIRFLVcGLGIDVDVRAKSSQLTALHYAAKEGQTNTVQTLLSLGADIN 301
Cdd:PHA02875 161 LDIEDCCGCTPLIIAMAKGDIAICKMLL-DSGANIDYFGKNGCVAALCYAIENNKIDIVRLFIKRGADCN 229
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 8-144 1.36e-05

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 47.00  E-value: 1.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808    8 RRLCRLVQEGRLRDLqEELAVARGCRGPAGDTLLHcAARHGRQD----ILAYLVEA-------WSMDIEATNRDYK--RP 74
Cdd:TIGR00870  54 SALFVAAIENENLEL-TELLLNLSCRGAVGDTLLH-AISLEYVDaveaILLHLLAAfrksgplELANDQYTSEFTPgiTA 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808   75 LHEAAsmgHRD---CVRYLLGRGAVV-------DSLKKADWT-------PLMMACTRKNLDVIQDLVEHGANPLLKNKDG 137
Cdd:TIGR00870 132 LHLAA---HRQnyeIVKLLLERGASVparacgdFFVKSQGVDsfyhgesPLNAAACLGSPSIVALLSEDPADILTADSLG 208


                  ....*..
gi 755496808  138 WNSFHIA 144
Cdd:TIGR00870 209 NTLLHLL 215
Ank_4 pfam13637
Ankyrin repeats (many copies);
242-294 3.89e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 40.72  E-value: 3.89e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 755496808  242 ALHRAAVTGQDEAIRFLVCgLGIDVDVRAKSSQlTALHYAAKEGQTNTVQTLL 294
Cdd:pfam13637   4 ALHAAAASGHLELLRLLLE-KGADINAVDGNGE-TALHFAASNGNVEVLKLLL 54
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 276-301 3.18e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.57  E-value: 3.18e-04
                           10        20
                   ....*....|....*....|....*.
gi 755496808   276 TALHYAAKEGQTNTVQTLLSLGADIN 301
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADIN 29
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 33-138 9.07e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 41.15  E-value: 9.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808  33 RGPAGDTLLHCAARHGRQDILAYLVEAWS--MDIEATNRDYK--RPLHEAASMGHRDCVRYLLGRGAVVDSlKKADWT-- 106
Cdd:cd22192   47 RGALGETALHVAALYDNLEAAVVLMEAAPelVNEPMTSDLYQgeTALHIAVVNQNLNLVRELIARGADVVS-PRATGTff 125

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 755496808 107 -------------PLMMACTRKNLDVIQDLVEHGANplLKNKDGW 138
Cdd:cd22192  126 rpgpknliyygehPLSFAACVGNEEIVRLLIEHGAD--IRAQDSL 168
Ank_2 pfam12796
Ankyrin repeats (3 copies);
278-314 1.84e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 37.02  E-value: 1.84e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 755496808  278 LHYAAKEGQTNTVQTLLSLGADINSTDERNRSVPHMC 314
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLA 37
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 104-130 1.98e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 35.26  E-value: 1.98e-03
                           10        20
                   ....*....|....*....|....*..
gi 755496808   104 DWTPLMMACTRKNLDVIQDLVEHGANP 130
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADI 28
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
35-258 1.38e-36

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 133.54  E-value: 1.38e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808  35 PAGDTLLHCAARHGRQDILAYLVEAWSMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAVVDSLKKADWTPLMMACTR 114
Cdd:COG0666   51 DALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808 115 KNLDVIQDLVEHGANPLLKNKDGWNSFHIASREGHPVILRYLLT--VCPDAwktESNIRRTPLHTAAMHGCLEAVQVLLE 192
Cdd:COG0666  131 GNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEagADVNA---RDNDGETPLHLAAENGHLEIVKLLLE 207

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755496808 193 RCHyEPDCRDNCGVTPFMDAIQCGHVSIAKLLLEqHKACSSAADSMGAQALHRAAVTGQDEAIRFL 258
Cdd:COG0666  208 AGA-DVNAKDNDGKTALDLAAENGNLEIVKLLLE-AGADLNAKDKDGLTALLLAAAAGAALIVKLL 271
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
39-301 3.00e-36

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 132.77  E-value: 3.00e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808  39 TLLHCAARHGRQDILAYLVEAWSMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAVVDSLKKADWTPLMMACTRKNLD 118
Cdd:COG0666   22 ALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLE 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808 119 VIQDLVEHGANPLLKNKDGWNSFHIASREGHPVILRYLLT--VCPDAWkteSNIRRTPLHTAAMHGCLEAVQVLLERcHY 196
Cdd:COG0666  102 IVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEagADVNAQ---DNDGNTPLHLAAANGNLEIVKLLLEA-GA 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808 197 EPDCRDNCGVTPFMDAIQCGHVSIAKLLLEqHKACSSAADSMGAQALHRAAVTGQDEAIRFLVcGLGIDVDVRAKSSqLT 276
Cdd:COG0666  178 DVNARDNDGETPLHLAAENGHLEIVKLLLE-AGADVNAKDNDGKTALDLAAENGNLEIVKLLL-EAGADLNAKDKDG-LT 254

                        250       260
                 ....*....|....*....|....*
gi 755496808 277 ALHYAAKEGQTNTVQTLLSLGADIN 301
Cdd:COG0666  255 ALLLAAAAGAALIVKLLLLALLLLA 279
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
33-230 2.31e-34

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 127.76  E-value: 2.31e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808  33 RGPAGDTLLHCAARHGRQDILAYLVEAwSMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAVVDSLKKADWTPLMMAC 112
Cdd:COG0666   83 KDDGGNTLLHAAARNGDLEIVKLLLEA-GADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAA 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808 113 TRKNLDVIQDLVEHGANPLLKNKDGWNSFHIASREGHPVILRYLLTVCPDAwKTESNIRRTPLHTAAMHGCLEAVQVLLE 192
Cdd:COG0666  162 ANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADV-NAKDNDGKTALDLAAENGNLEIVKLLLE 240

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 755496808 193 RcHYEPDCRDNCGVTPFMDAIQCGHVSIAKLLLEQHKA 230
Cdd:COG0666  241 A-GADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLL 277
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
62-312 4.61e-33

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 124.30  E-value: 4.61e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808  62 MDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAVVDSLKKADWTPLMMACTRKNLDVIQDLVEHGANPLLKNKDGWNSF 141
Cdd:COG0666   12 LAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808 142 HIASREGHPVILRYLLtvcpdAWKTESNIR----RTPLHTAAMHGCLEAVQVLLERcHYEPDCRDNCGVTPFMDAIQCGH 217
Cdd:COG0666   92 HAAARNGDLEIVKLLL-----EAGADVNARdkdgETPLHLAAYNGNLEIVKLLLEA-GADVNAQDNDGNTPLHLAAANGN 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808 218 VSIAKLLLEqHKACSSAADSMGAQALHRAAVTGQDEAIRFLVcGLGIDVDVRAKsSQLTALHYAAKEGQTNTVQTLLSLG 297
Cdd:COG0666  166 LEIVKLLLE-AGADVNARDNDGETPLHLAAENGHLEIVKLLL-EAGADVNAKDN-DGKTALDLAAENGNLEIVKLLLEAG 242

                        250
                 ....*....|....*
gi 755496808 298 ADINSTDERNRSVPH 312
Cdd:COG0666  243 ADLNAKDKDGLTALL 257
Ank_2 pfam12796
Ankyrin repeats (3 copies);
175-304 1.02e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 79.77  E-value: 1.02e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808  175 LHTAAMHGCLEAVQVLLErCHYEPDCRDNCGVTPFMDAIQCGHVSIAKLLLEQhkacssaadsmgaqalhraavtgqdea 254
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLE-NGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH--------------------------- 52

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 755496808  255 irflvcglgidVDVRAKSSQLTALHYAAKEGQTNTVQTLLSLGADINSTD 304
Cdd:pfam12796  53 -----------ADVNLKDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
108-193 5.25e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 72.46  E-value: 5.25e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808  108 LMMACTRKNLDVIQDLVEHGANPLLKNKDGWNSFHIASREGHPVILRYLLTVCPdawKTESNIRRTPLHTAAMHGCLEAV 187
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD---VNLKDNGRTALHYAARSGHLEIV 77


                  ....*.
gi 755496808  188 QVLLER 193
Cdd:pfam12796  78 KLLLEK 83
Ank_2 pfam12796
Ankyrin repeats (3 copies);
141-226 6.10e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 72.07  E-value: 6.10e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808  141 FHIASREGHPVILRYLLTVCPDAWKTESNiRRTPLHTAAMHGCLEAVQVLLErcHYEPDCRDNcGVTPFMDAIQCGHVSI 220
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKN-GRTALHLAAKNGHLEIVKLLLE--HADVNLKDN-GRTALHYAARSGHLEI 76


                  ....*.
gi 755496808  221 AKLLLE 226
Cdd:pfam12796  77 VKLLLE 82
Ank_2 pfam12796
Ankyrin repeats (3 copies);
41-134 8.67e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 71.69  E-value: 8.67e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808   41 LHCAARHGRQDILAYLVEAWSmDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAVvdSLKKADWTPLMMACTRKNLDVI 120
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGA-DANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV--NLKDNGRTALHYAARSGHLEIV 77

                          90
                  ....*....|....
gi 755496808  121 QDLVEHGANPLLKN 134
Cdd:pfam12796  78 KLLLEKGADINVKD 91
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 75-301 4.68e-15

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 75.80  E-value: 4.68e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808  75 LHEAASMGHRDCVRYLLGRGAVVDSLKKADWTPLMMACTRKNLDVIQDLVEHGANPLLKNKDGWNSFHIASREGHPVILR 154
Cdd:PHA02875   6 LCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVE 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808 155 YLL---TVCPDAWKTESNirrTPLHTAAMHGCLEAVQVLLERcHYEPDCRDNCGVTPFMDAIQCGHVSIAKLLLEqHKAC 231
Cdd:PHA02875  86 ELLdlgKFADDVFYKDGM---TPLHLATILKKLDIMKLLIAR-GADPDIPNTDKFSPLHLAVMMGDIKGIELLID-HKAC 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808 232 SSAADSMGAQALHRAAVTGQDEAIRFLVcGLGIDVDVRAKSSQLTALHYAAKEGQTNTVQTLLSLGADIN 301
Cdd:PHA02875 161 LDIEDCCGCTPLIIAMAKGDIAICKMLL-DSGANIDYFGKNGCVAALCYAIENNKIDIVRLFIKRGADCN 229
Ank_2 pfam12796
Ankyrin repeats (3 copies);
75-157 1.18e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 65.91  E-value: 1.18e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808   75 LHEAASMGHRDCVRYLLGRGAVVDSLKKADWTPLMMACTRKNLDVIQDLVEHGAnpLLKNKDGWNSFHIASREGHPVILR 154
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD--VNLKDNGRTALHYAARSGHLEIVK 78


                  ...
gi 755496808  155 YLL 157
Cdd:pfam12796  79 LLL 81
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 62-316 4.25e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 67.01  E-value: 4.25e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808  62 MDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAVVDSLKKADWTPLMMACTRKNLDVIQDLVEHGANpllKNKDGWNSF 141
Cdd:PHA02876 169 ADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSN---INKNDLSLL 245

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808 142 HIASREGHPVILryLLTVCPDAWKTESNIRRTPLHTAAMHGCLEA-VQVLLERcHYEPDCRDNCGVTPFMDAIQCGHVSI 220
Cdd:PHA02876 246 KAIRNEDLETSL--LLYDAGFSVNSIDDCKNTPLHHASQAPSLSRlVPKLLER-GADVNAKNIKGETPLYLMAKNGYDTE 322

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808 221 AKLLLEQHKACSSAADSMGAQALHRAAVTGQDEAIRFLVCGLGIDVDVRAKSSQlTALHYAAKEGQTNTVQTLLSLGADI 300
Cdd:PHA02876 323 NIRTLIMLGADVNAADRLYITPLHQASTLDRNKDIVITLLELGANVNARDYCDK-TPIHYAAVRNNVVIINTLLDYGADI 401

                        250
                 ....*....|....*.
gi 755496808 301 NSTDERNRSVPHMCRC 316
Cdd:PHA02876 402 EALSQKIGTALHFALC 417
PHA03095 PHA03095
ankyrin-like protein; Provisional
 32-309 8.80e-12

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 65.82  E-value: 8.80e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808  32 CRGPAGDTLLHCAAR---HGRQDILAYLVEAwSMDIEATNRDYKRPLHEAASMGHR-DCVRYLLGRGAVVDSLKKADWTP 107
Cdd:PHA03095  42 FRGEYGKTPLHLYLHyssEKVKDIVRLLLEA-GADVNAPERCGFTPLHLYLYNATTlDVIKLLIKAGADVNAKDKVGRTP 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808 108 LMMACTRKNLD--VIQDLVEHGANPLLKNKDGWNSFHI--ASREGHPVILRYLLTVCPDAWkTESNIRRTPLHtaamhgc 183
Cdd:PHA03095 121 LHVYLSGFNINpkVIRLLLRKGADVNALDLYGMTPLAVllKSRNANVELLRLLIDAGADVY-AVDDRFRSLLH------- 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808 184 leavqvllercHYEPDCRDNCGVTPFMDAIQCGhvsiakllleqhkacSSAADSMGAQALHRAAVTGQDEA--IRFLVCG 261
Cdd:PHA03095 193 -----------HHLQSFKPRARIVRELIRAGCD---------------PAATDMLGNTPLHSMATGSSCKRslVLPLLIA 246

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 755496808 262 lGIDVDVRAKSSQlTALHYAAKEGQTNTVQTLLSLGADINSTDERNRS 309
Cdd:PHA03095 247 -GISINARNRYGQ-TPLHYAAVFNNPRACRRLIALGADINAVSSDGNT 292
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
33-139 8.90e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 61.89  E-value: 8.90e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808  33 RGPAGDTLLHCAARHGRQDILAYLVEAwSMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAVVDSLKKADWTPLMMAC 112
Cdd:COG0666  182 RDNDGETPLHLAAENGHLEIVKLLLEA-GADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAA 260

                         90       100
                 ....*....|....*....|....*..
gi 755496808 113 TRKNLDVIQDLVEHGANPLLKNKDGWN 139
Cdd:COG0666  261 AAGAALIVKLLLLALLLLAAALLDLLT 287
Ank_2 pfam12796
Ankyrin repeats (3 copies);
31-99 2.21e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 56.66  E-value: 2.21e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755496808   31 GCRGPAGDTLLHCAARHGRQDILAYLVEawSMDIEATNRDYKrPLHEAASMGHRDCVRYLLGRGAVVDS 99
Cdd:pfam12796  24 NLQDKNGRTALHLAAKNGHLEIVKLLLE--HADVNLKDNGRT-ALHYAARSGHLEIVKLLLEKGADINV 89
Ank_4 pfam13637
Ankyrin repeats (many copies);
171-225 2.00e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 52.66  E-value: 2.00e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 755496808  171 RRTPLHTAAMHGCLEAVQVLLERcHYEPDCRDNCGVTPFMDAIQCGHVSIAKLLL 225
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEK-GADINAVDGNGETALHFAASNGNVEVLKLLL 54
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 172-305 4.69e-09

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 57.96  E-value: 4.69e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808 172 RTPLHTAAMHGCLEAVQVLLER-CHYepDCRDNCGVTPFMDAIQCGHVSIAKLLLEqhkaCSSAADS-MGAQALHRAAVT 249
Cdd:PLN03192 559 RTPLHIAASKGYEDCVLVLLKHaCNV--HIRDANGNTALWNAISAKHHKIFRILYH----FASISDPhAAGDLLCTAAKR 632

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 755496808 250 GQDEAIRFLVcGLGIDVDVRAKSSqLTALHYAAKEGQTNTVQTLLSLGADIN--STDE 305
Cdd:PLN03192 633 NDLTAMKELL-KQGLNVDSEDHQG-ATALQVAMAEDHVDMVRLLIMNGADVDkaNTDD 688
Ank_4 pfam13637
Ankyrin repeats (many copies);
37-91 8.71e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 51.12  E-value: 8.71e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 755496808   37 GDTLLHCAARHGRQDILAYLVEAWsMDIEATNRDYKRPLHEAASMGHRDCVRYLL 91
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKG-ADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
105-157 2.77e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.58  E-value: 2.77e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 755496808  105 WTPLMMACTRKNLDVIQDLVEHGANPLLKNKDGWNSFHIASREGHPVILRYLL 157
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 118-304 5.20e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 54.12  E-value: 5.20e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808 118 DVIQDLVEHGANPLLKNKDGWNS-FHIASREGHPVILRYLLTvcpdaWKTESNI----RRTPLHTAAMHGCLEAVQVLLE 192
Cdd:PHA02878 148 EITKLLLSYGADINMKDRHKGNTaLHYATENKDQRLTELLLS-----YGANVNIpdktNNSPLHHAVKHYNKPIVHILLE 222

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808 193 RCHYEpDCRDNCGVTPFMDAI-QCGHVSIAKLLLEQhkacssaadsmgaqalhraavtgqdeairflvcglGIDVDVRAK 271
Cdd:PHA02878 223 NGAST-DARDKCGNTPLHISVgYCKDYDILKLLLEH-----------------------------------GVDVNAKSY 266

                        170       180       190
                 ....*....|....*....|....*....|...
gi 755496808 272 SSQLTALHYAAKEGQtnTVQTLLSLGADINSTD 304
Cdd:PHA02878 267 ILGLTALHSSIKSER--KLKLLLEYGADINSLN 297
PHA03095 PHA03095
ankyrin-like protein; Provisional
 37-259 6.10e-08

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 53.88  E-value: 6.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808  37 GDTLLHCAARHG-RQDILAYLVEAwSMDIEATNRDYKRPLHE-AASMG-HRDCVRYLLGRGAVVDSLKKADWTPL--MMA 111
Cdd:PHA03095  83 GFTPLHLYLYNAtTLDVIKLLIKA-GADVNAKDKVGRTPLHVyLSGFNiNPKVIRLLLRKGADVNALDLYGMTPLavLLK 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808 112 CTRKNLDVIQDLVEHGANPLLKNKDGWNSFHI--ASREGHPVILRYLLTVCPDAWKTEsNIRRTPLHTAAMHGCLEAVQV 189
Cdd:PHA03095 162 SRNANVELLRLLIDAGADVYAVDDRFRSLLHHhlQSFKPRARIVRELIRAGCDPAATD-MLGNTPLHSMATGSSCKRSLV 240

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808 190 --LLER--------------------------CHY------EPDCRDNCGVTPFMDAIQCGHVSIAKLLLEQHkacsSAA 235
Cdd:PHA03095 241 lpLLIAgisinarnrygqtplhyaavfnnpraCRRlialgaDINAVSSDGNTPLSLMVRNNNGRAVRAALAKN----PSA 316

                        250       260
                 ....*....|....*....|....*..
gi 755496808 236 DSMgAQALHRAAVTGQD---EAIRFLV 259
Cdd:PHA03095 317 ETV-AATLNTASVAGGDipsDATRLCV 342
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 56-178 6.27e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 54.12  E-value: 6.27e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808  56 LVEAWSMDIEATNRDY-KRPLHEAASMGHRDCVRYLLGRGAVVDSLKKADWTPLMMACTRKNLDVIQDLVEHGANPLLKN 134
Cdd:PHA02878 152 LLLSYGADINMKDRHKgNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARD 231

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 755496808 135 KDGWNSFHIA-SREGHPVILRYLLT--VCPDAwktESNIRR-TPLHTA 178
Cdd:PHA02878 232 KCGNTPLHISvGYCKDYDILKLLLEhgVDVNA---KSYILGlTALHSS 276
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 87-314 9.99e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 53.13  E-value: 9.99e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808  87 VRYLLGRGAVVDSLKKADWTPLMMACTRKNLDVIQDLVEHGANPLLKNKDGWNSFHIASREGHpvilrylltvcpdawkt 166
Cdd:PHA03100  18 IKYIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKY----------------- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808 167 esNIRRTPlhtaamhgclEAVQVLLERCHYePDCRDNCGVTPFMDAIQC--GHVSIAKLLLeQHKACSSAADSMGAQALH 244
Cdd:PHA03100  81 --NLTDVK----------EIVKLLLEYGAN-VNAPDNNGITPLLYAISKksNSYSIVEYLL-DNGANVNIKNSDGENLLH 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808 245 RAAVTGQD--EAIRFLVCGlGIDVDVRAKSSQL---------------TALHYAAKEGQTNTVQTLLSLGADINSTDERN 307
Cdd:PHA03100 147 LYLESNKIdlKILKLLIDK-GVDINAKNRVNYLlsygvpinikdvygfTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYG 225


                 ....*..
gi 755496808 308 RSVPHMC 314
Cdd:PHA03100 226 DTPLHIA 232
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 90-308 3.62e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 51.99  E-value: 3.62e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808  90 LLGRGAVVDSLKKADWTPLMMACTRKNLD-VIQDLVEHGANPLLKNKDGWNSFHIASREGHPVI-LRYLLTVCPDAWKTE 167
Cdd:PHA02876 259 LYDAGFSVNSIDDCKNTPLHHASQAPSLSrLVPKLLERGADVNAKNIKGETPLYLMAKNGYDTEnIRTLIMLGADVNAAD 338

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808 168 SnIRRTPLHTAAMHGCLEAVQVLLERCHYEPDCRDNCGVTPFMDAIQCGHVSIAKLLLEQHKACSSAADSMGAqALHRAA 247
Cdd:PHA02876 339 R-LYITPLHQASTLDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGT-ALHFAL 416

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755496808 248 V-TGQDEAIRFLVcGLGIDVDVRAKSSQlTALHYAAKEG-QTNTVQTLLSLGADINSTDERNR 308
Cdd:PHA02876 417 CgTNPYMSVKTLI-DRGANVNSKNKDLS-TPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQ 477
Ank_4 pfam13637
Ankyrin repeats (many copies);
73-124 5.22e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 46.11  E-value: 5.22e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 755496808   73 RPLHEAASMGHRDCVRYLLGRGAVVDSLKKADWTPLMMACTRKNLDVIQDLV 124
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 37-130 2.58e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 48.83  E-value: 2.58e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808  37 GDTLLHCAARHGRQDILAYLVeAWSMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAVVDSLKKADWTPLMMACTRKN 116
Cdd:PHA02875 102 GMTPLHLATILKKLDIMKLLI-ARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGD 180

                         90
                 ....*....|....
gi 755496808 117 LDVIQDLVEHGANP 130
Cdd:PHA02875 181 IAICKMLLDSGANI 194
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 37-171 3.20e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 48.51  E-value: 3.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808  37 GDTLLHCAARHGRQD--ILAYLvEAWSMDIEATNRDYKRPLHEAASMGHRDC------------------VRYLLGRGAV 96
Cdd:PHA03100 106 GITPLLYAISKKSNSysIVEYL-LDNGANVNIKNSDGENLLHLYLESNKIDLkilkllidkgvdinaknrVNYLLSYGVP 184

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755496808  97 VDSLKKADWTPLMMACTRKNLDVIQDLVEHGANPLLKNKDGWNSFHIASREGHPVILRYLLTVCPDAWKTESNIR 171
Cdd:PHA03100 185 INIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTIIETLL 259
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 90-312 4.88e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 48.14  E-value: 4.88e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808  90 LLGRGAVVDSLKKADWTPLMMACTRKNLDVIQDLVEHGANPLLKNKDGWNSFHIASREGHPVILRYLLtvcpdawKTESN 169
Cdd:PHA02876 164 LLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAII-------DNRSN 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808 170 IRRTPLH--TAAMHGCLEAvQVLLERCHYEPDCRDNCGVTPFMDAIQCGHVS--IAKLLleQHKACSSAADSMGAQALHR 245
Cdd:PHA02876 237 INKNDLSllKAIRNEDLET-SLLLYDAGFSVNSIDDCKNTPLHHASQAPSLSrlVPKLL--ERGADVNAKNIKGETPLYL 313

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755496808 246 AAVTGQD-EAIRFLVCgLGIDVDVrAKSSQLTALHYAAK-EGQTNTVQTLLSLGADINSTDERNRSVPH 312
Cdd:PHA02876 314 MAKNGYDtENIRTLIM-LGADVNA-ADRLYITPLHQASTlDRNKDIVITLLELGANVNARDYCDKTPIH 380
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 175-304 6.78e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 47.65  E-value: 6.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808 175 LHTAAMHGCLEAVQVLLERchyepdcRDNC-------GVTPFMDAIQCGHVSIAKLLLeQHKACSSAADSMGAQALHRAA 247
Cdd:PHA02874   5 LRMCIYSGDIEAIEKIIKN-------KGNCinisvdeTTTPLIDAIRSGDAKIVELFI-KHGADINHINTKIPHPLLTAI 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755496808 248 VTGQDEAIRFL----------------------VCGLGIDVDVRAKSSQlTALHYAAKEGQTNTVQTLLSLGADINSTD 304
Cdd:PHA02874  77 KIGAHDIIKLLidngvdtsilpipciekdmiktILDCGIDVNIKDAELK-TFLHYAIKKGDLESIKMLFEYGADVNIED 154
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 84-246 9.41e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 47.27  E-value: 9.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808  84 RDCVRYLLGRGAVVDSLKKADWTPLMMACTRKNLDVIQDLVEHGANPLLKNKDGWNSFHIASREGHPVILRYLLTVCPDA 163
Cdd:PHA02874 104 KDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYA 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808 164 WKTESNIrRTPLHTAAMHGCLEAVQVLLERC-HYEPDCrdNCGVTPFMDAIqCGHVSIAKLLLeqHKACSSAADSMGAQA 242
Cdd:PHA02874 184 NVKDNNG-ESPLHNAAEYGDYACIKLLIDHGnHIMNKC--KNGFTPLHNAI-IHNRSAIELLI--NNASINDQDIDGSTP 257


                 ....
gi 755496808 243 LHRA 246
Cdd:PHA02874 258 LHHA 261
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 8-144 1.36e-05

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 47.00  E-value: 1.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808    8 RRLCRLVQEGRLRDLqEELAVARGCRGPAGDTLLHcAARHGRQD----ILAYLVEA-------WSMDIEATNRDYK--RP 74
Cdd:TIGR00870  54 SALFVAAIENENLEL-TELLLNLSCRGAVGDTLLH-AISLEYVDaveaILLHLLAAfrksgplELANDQYTSEFTPgiTA 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808   75 LHEAAsmgHRD---CVRYLLGRGAVV-------DSLKKADWT-------PLMMACTRKNLDVIQDLVEHGANPLLKNKDG 137
Cdd:TIGR00870 132 LHLAA---HRQnyeIVKLLLERGASVparacgdFFVKSQGVDsfyhgesPLNAAACLGSPSIVALLSEDPADILTADSLG 208


                  ....*..
gi 755496808  138 WNSFHIA 144
Cdd:TIGR00870 209 NTLLHLL 215
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 75-169 2.25e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 46.04  E-value: 2.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808  75 LHEAASMGHRDCVRYLLGRGAVVDSLKKADWTPLMMACTRKNLDVIQDLVEHGANPLLKNKDGWNSFHIASREGHPVILR 154
Cdd:PTZ00322  86 LCQLAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQ 165

                         90
                 ....*....|....*
gi 755496808 155 YLLTVCPDAWKTESN 169
Cdd:PTZ00322 166 LLSRHSQCHFELGAN 180
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 37-158 2.76e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 46.01  E-value: 2.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808  37 GDTLLHCAARHGRQD-ILAYLVEAWSMDIEATNRDykRPLHEAASMGHRDCVRYLLGRGAVVDSLKKADWtpLMMACTRK 115
Cdd:PLN03192 558 GRTPLHIAASKGYEDcVLVLLKHACNVHIRDANGN--TALWNAISAKHHKIFRILYHFASISDPHAAGDL--LCTAAKRN 633

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 755496808 116 NLDVIQDLVEHGANPLLKNKDGWNSFHIASREGHPVILRYLLT 158
Cdd:PLN03192 634 DLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIM 676
Ank_4 pfam13637
Ankyrin repeats (many copies);
242-294 3.89e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 40.72  E-value: 3.89e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 755496808  242 ALHRAAVTGQDEAIRFLVCgLGIDVDVRAKSSQlTALHYAAKEGQTNTVQTLL 294
Cdd:pfam13637   4 ALHAAAASGHLELLRLLLE-KGADINAVDGNGE-TALHFAASNGNVEVLKLLL 54
Ank_5 pfam13857
Ankyrin repeats (many copies);
106-144 1.09e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 39.64  E-value: 1.09e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 755496808  106 TPLMMACTRKNLDVIQDLVEHGANPLLKNKDGWNSFHIA 144
Cdd:pfam13857  18 TPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 107-312 1.93e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 42.95  E-value: 1.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808 107 PLMMACTRKNLDVIQDLVEHGANPLLKNKDGWNSFHIASREGHPVILRYLLTVcpdawKTESNIRRTplhtaamhgcLEA 186
Cdd:PHA02878  40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRS-----INKCSVFYT----------LVA 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808 187 VQvllERCHYEpdcrdncgvtpfmdaiqcgHVSIAKLLLEQHKACSSAADSMgaQALHRAAVTGQDEAIRFLVCGLGIDV 266
Cdd:PHA02878 105 IK---DAFNNR-------------------NVEIFKIILTNRYKNIQTIDLV--YIDKKSKDDIIEAEITKLLLSYGADI 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 755496808 267 DVRAKSSQLTALHYAAKEGQTNTVQTLLSLGADINSTDERNRSVPH 312
Cdd:PHA02878 161 NMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLH 206
Ank_5 pfam13857
Ankyrin repeats (many copies);
190-246 2.42e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.48  E-value: 2.42e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 755496808  190 LLERCHYEPDCRDNCGVTPFMDAIQCGHVSIAKLLLEQHKACsSAADSMGAQALHRA 246
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDL-NLKDEEGLTALDLA 56
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 28-203 2.74e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 42.74  E-value: 2.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808  28 VARGCRGPAGDTL----LHCAARHGR-QDILAYLVEawsMDIEATNRDY--KRPLHEAASMGHRDCVRYLLGRGAVVDSL 100
Cdd:PHA02876 328 IMLGADVNAADRLyitpLHQASTLDRnKDIVITLLE---LGANVNARDYcdKTPIHYAAVRNNVVIINTLLDYGADIEAL 404

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808 101 KKADWTPLMMA-CTRKNLDVIQDLVEHGANPLLKNKDGWNSFHIASREG-HPVILRYLLTVCPDAwkTESNIR-RTPLHT 177
Cdd:PHA02876 405 SQKIGTALHFAlCGTNPYMSVKTLIDRGANVNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGADV--NAINIQnQYPLLI 482

                        170       180
                 ....*....|....*....|....*..
gi 755496808 178 A-AMHGCleaVQVLLercHYEPDCRDN 203
Cdd:PHA02876 483 AlEYHGI---VNILL---HYGAELRDS 503
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 276-301 3.18e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.57  E-value: 3.18e-04
                           10        20
                   ....*....|....*....|....*.
gi 755496808   276 TALHYAAKEGQTNTVQTLLSLGADIN 301
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADIN 29
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 276-305 5.35e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 36.88  E-value: 5.35e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 755496808  276 TALHYAA-KEGQTNTVQTLLSLGADINSTDE 305
Cdd:pfam00023   4 TPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
Ank_4 pfam13637
Ankyrin repeats (many copies);
274-314 5.54e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 37.64  E-value: 5.54e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 755496808  274 QLTALHYAAKEGQTNTVQTLLSLGADINSTDERNRSVPHMC 314
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFA 41
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 105-135 6.64e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 36.88  E-value: 6.64e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 755496808  105 WTPLMMACTR-KNLDVIQDLVEHGANPLLKNK 135
Cdd:pfam00023   3 NTPLHLAAGRrGNLEIVKLLLSKGADVNARDK 34
Ank_5 pfam13857
Ankyrin repeats (many copies);
56-111 7.28e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 37.33  E-value: 7.28e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 755496808   56 LVEAWSMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAVVDSLKKADWTPLMMA 111
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 69-126 8.63e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 41.04  E-value: 8.63e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808  69 RDY--KRPLHEAASMGHRDCVRYLLGRGAVVDSLKKADWTPLMMACTRKNLDVIQDLVEH 126
Cdd:PTZ00322 111 RDYdgRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRH 170
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 33-138 9.07e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 41.15  E-value: 9.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808  33 RGPAGDTLLHCAARHGRQDILAYLVEAWS--MDIEATNRDYK--RPLHEAASMGHRDCVRYLLGRGAVVDSlKKADWT-- 106
Cdd:cd22192   47 RGALGETALHVAALYDNLEAAVVLMEAAPelVNEPMTSDLYQgeTALHIAVVNQNLNLVRELIARGADVVS-PRATGTff 125

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 755496808 107 -------------PLMMACTRKNLDVIQDLVEHGANplLKNKDGW 138
Cdd:cd22192  126 rpgpknliyygehPLSFAACVGNEEIVRLLIEHGAD--IRAQDSL 168
Ank_2 pfam12796
Ankyrin repeats (3 copies);
278-314 1.84e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 37.02  E-value: 1.84e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 755496808  278 LHYAAKEGQTNTVQTLLSLGADINSTDERNRSVPHMC 314
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLA 37
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 104-130 1.98e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 35.26  E-value: 1.98e-03
                           10        20
                   ....*....|....*....|....*..
gi 755496808   104 DWTPLMMACTRKNLDVIQDLVEHGANP 130
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADI 28
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 74-98 2.10e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 35.26  E-value: 2.10e-03
                           10        20
                   ....*....|....*....|....*
gi 755496808    74 PLHEAASMGHRDCVRYLLGRGAVVD 98
Cdd:smart00248   5 PLHLAAENGNLEVVKLLLDKGADIN 29
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 207-302 2.27e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 39.61  E-value: 2.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808 207 TPFMDAIQCGHVSIAKLLLEQHKACSSAADSMGAQALHRAAVTGQDEAIRFLvcglgIDVDVR----AKSSQL----TAL 278
Cdd:cd22192   19 SPLLLAAKENDVQAIKKLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVL-----MEAAPElvnePMTSDLyqgeTAL 93

                         90       100
                 ....*....|....*....|....
gi 755496808 279 HYAAKEGQTNTVQTLLSLGADINS 302
Cdd:cd22192   94 HIAVVNQNLNLVRELIARGADVVS 117
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 35-225 4.45e-03

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 39.08  E-value: 4.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808  35 PAGDTLLHCAARHGRQDILAYLVEAwSMDIEATNRDYKRPLHEAASMGHRDCVRYLLgrgavvdslkkadwtplmmactr 114
Cdd:PLN03192 523 PNMASNLLTVASTGNAALLEELLKA-KLDPDIGDSKGRTPLHIAASKGYEDCVLVLL----------------------- 578

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808 115 knldviqdlvEHGANPLLKNKDG----WNSfhIASreGHPVILRYLLTVcpdAWKTESNIRRTPLHTAAMHGCLEAVQVL 190
Cdd:PLN03192 579 ----------KHACNVHIRDANGntalWNA--ISA--KHHKIFRILYHF---ASISDPHAAGDLLCTAAKRNDLTAMKEL 641

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 755496808 191 LERcHYEPDCRDNCGVTPFMDAIQCGHVSIAKLLL 225
Cdd:PLN03192 642 LKQ-GLNVDSEDHQGATALQVAMAEDHVDMVRLLI 675
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 35-157 7.01e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 38.05  E-value: 7.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808  35 PAGDTLLHCAARHGRQDILAYLVEAWSMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAVVDSLKKADWTPLMMACTR 114
Cdd:PHA02875  66 PDIESELHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMM 145

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 755496808 115 KNLDVIQDLVEHGANPLLKNKDGWNSFHIASREGHPVILRYLL 157
Cdd:PHA02875 146 GDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLL 188
Ank_5 pfam13857
Ankyrin repeats (many copies);
166-209 7.75e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 34.24  E-value: 7.75e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 755496808  166 TESNIRRTPLHTAAMHGCLEAVQVLLERcHYEPDCRDNCGVTPF 209
Cdd:pfam13857  11 RLDGEGYTPLHVAAKYGALEIVRVLLAY-GVDLNLKDEEGLTAL 53
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 25-129 9.00e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 38.12  E-value: 9.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808  25 ELAVARGCRGPAGDTLLHCAARHGRQDILAYLVEaWSMDIEATNRDYKRPLHEA-ASMGHRDCVRYLLGRGAVVDSLKKA 103
Cdd:PHA02876 363 ELGANVNARDYCDKTPIHYAAVRNNVVIINTLLD-YGADIEALSQKIGTALHFAlCGTNPYMSVKTLIDRGANVNSKNKD 441

                         90       100
                 ....*....|....*....|....*..
gi 755496808 104 DWTPLMMACTRK-NLDVIQDLVEHGAN 129
Cdd:PHA02876 442 LSTPLHYACKKNcKLDVIEMLLDNGAD 468
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 37-144 9.25e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 37.64  E-value: 9.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808  37 GDTLLHCAARHGRQDILAYLVEAWSMdIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAVVDSLKKADWTPLMMACTRkN 116
Cdd:PHA02874 157 GCYPIHIAIKHNFFDIIKLLLEKGAY-ANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIH-N 234

                         90       100
                 ....*....|....*....|....*...
gi 755496808 117 LDVIQDLVEHgANPLLKNKDGWNSFHIA 144
Cdd:PHA02874 235 RSAIELLINN-ASINDQDIDGSTPLHHA 261
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 32-92 9.52e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 37.96  E-value: 9.52e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755496808  32 CRGPAGDTLLHCAARHGRQDILAYLVEaWSMDIEATNRDYKRPLHEAASMGHRDCVRYLLG 92
Cdd:PTZ00322 110 CRDYDGRTPLHIACANGHVQVVRVLLE-FGADPTLLDKDGKTPLELAEENGFREVVQLLSR 169
PHA03095 PHA03095
ankyrin-like protein; Provisional
 28-116 9.60e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 37.70  E-value: 9.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755496808  28 VARGCRGPA----GDTLLHCAARHG--RQDILAYLVEAwSMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAVVDSLK 101
Cdd:PHA03095 209 IRAGCDPAAtdmlGNTPLHSMATGSscKRSLVLPLLIA-GISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVS 287

                         90
                 ....*....|....*
gi 755496808 102 KADWTPLMMACTRKN 116
Cdd:PHA03095 288 SDGNTPLSLMVRNNN 302
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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