NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|755504769|ref|XP_011238597|]
View 

netrin-G1 isoform X5 [Mus musculus]

Protein Classification

calcium-binding EGF-like domain-containing protein; attractin family protein( domain architecture ID 10441288)

calcium-binding epidermal growth factor (EGF)-like domain-containing protein may play a crucial role in numerous protein-protein interactions| attractin family protein similar to middle and C-terminal regions of Homo sapiens attractin that is involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Laminin_N pfam00055
Laminin N-terminal (Domain VI);
50-295 2.32e-76

Laminin N-terminal (Domain VI);


:

Pssm-ID: 459653  Cd Length: 230  Bit Score: 239.41  E-value: 2.32e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755504769   50 CQPESTDMTKYLKVKldpPDITCG-DPPESFCAMGNP---YMCNnECDASTPELAHPPELMFDFEGRHPSTFWQSATWke 125
Cdd:pfam00055   1 CYPAFGNLAFGREVS---ATSTCGlNGPERYCILSGLeggKKCF-ICDSRDPHNSHPPSNLTDSNNGTNETWWQSETG-- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755504769  126 YPKPLQVNITLSWSKTIELTDnIVITFESGRPDQMILEKSLDYGRTWQPYQYYATDCLHAFHMDPKSVKDLSQHtvlEII 205
Cdd:pfam00055  75 VIQYENVNLTLDLGKEFHFTY-LILKFKSPRPAAMVLERSTDFGKTWQPYQYFASDCRRTFGRPSGPSRGIKDD---EVI 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755504769  206 CTEEYSTGY-STNSKIIhfeikdrFAFFAGPRLRNMAslygqlDTTKKLRDFFTVTDLRIRLLRPA--VGEIFVDELHLA 282
Cdd:pfam00055 151 CTSEYSDISpLTGGEVI-------FSTLEGRPSANIF------DYSPELQDWLTATNIRIRLLRLHtlGDELLDDPSVLR 217

                         250
                  ....*....|...
gi 755504769  283 RYFYAISDIKVRG 295
Cdd:pfam00055 218 KYYYAISDISVGG 230
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 296-342 2.71e-07

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 46.96  E-value: 2.71e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 755504769 296 RCKCNLHATSCLY-DNSKLTCECEHNTTGPDCGKCKKNYQGRPWSPGS 342
Cdd:cd00055    1 PCDCNGHGSLSGQcDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGG 48
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 364-412 1.45e-04

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 39.26  E-value: 1.45e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 755504769 364 CECFGHSNRCSYIDLlNTVICVsCKHNTRGQHCELCRLGYFRNASAQLD 412
Cdd:cd00055    2 CDCNGHGSLSGQCDP-GTGQCE-CKPNTTGRRCDRCAPGYYGLPSQGGG 48
 
Name Accession Description Interval E-value
Laminin_N pfam00055
Laminin N-terminal (Domain VI);
50-295 2.32e-76

Laminin N-terminal (Domain VI);


Pssm-ID: 459653  Cd Length: 230  Bit Score: 239.41  E-value: 2.32e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755504769   50 CQPESTDMTKYLKVKldpPDITCG-DPPESFCAMGNP---YMCNnECDASTPELAHPPELMFDFEGRHPSTFWQSATWke 125
Cdd:pfam00055   1 CYPAFGNLAFGREVS---ATSTCGlNGPERYCILSGLeggKKCF-ICDSRDPHNSHPPSNLTDSNNGTNETWWQSETG-- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755504769  126 YPKPLQVNITLSWSKTIELTDnIVITFESGRPDQMILEKSLDYGRTWQPYQYYATDCLHAFHMDPKSVKDLSQHtvlEII 205
Cdd:pfam00055  75 VIQYENVNLTLDLGKEFHFTY-LILKFKSPRPAAMVLERSTDFGKTWQPYQYFASDCRRTFGRPSGPSRGIKDD---EVI 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755504769  206 CTEEYSTGY-STNSKIIhfeikdrFAFFAGPRLRNMAslygqlDTTKKLRDFFTVTDLRIRLLRPA--VGEIFVDELHLA 282
Cdd:pfam00055 151 CTSEYSDISpLTGGEVI-------FSTLEGRPSANIF------DYSPELQDWLTATNIRIRLLRLHtlGDELLDDPSVLR 217

                         250
                  ....*....|...
gi 755504769  283 RYFYAISDIKVRG 295
Cdd:pfam00055 218 KYYYAISDISVGG 230
LamNT smart00136
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related ...
 71-295 6.43e-40

Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related protein such as Unc-6/ netrins.


Pssm-ID: 214532  Cd Length: 238  Bit Score: 144.04  E-value: 6.43e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755504769    71 TCGDP-PESFCAMgNPYMCNNE----CDASTPELAHPPELMFDFEGRHPSTFWQSATWKEYPKplQVNITLSWSKTIELT 145
Cdd:smart00136  25 TCGEPgPERYCKL-VGHTEQGKkcdyCDARNPRRSHPAENLTDGNNPNNPTWWQSEPLSNGPQ--NVNLTLDLGKEFHVT 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755504769   146 dNIVITFESGRPDQMILEKSlDYGRTWQPYQYYATDCLHAFHMDPKSVKDLSQHTvlEIICTEEYS-TGYSTNSKIIHFE 224
Cdd:smart00136 102 -YVILKFCSPRPSLWILERS-DFGKTWQPWQYFSSDCRRTFGRPPRGPITKGNED--EVICTSEYSdIVPLEGGEIAFSL 177

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755504769   225 IKDRfaffagPRLRNmaslygqLDTTKKLRDFFTVTDLRIRLLRPAV--GEIFVDELH-LARYFYAISDIKVRG 295
Cdd:smart00136 178 LEGR------PSATD-------FDNSPVLQEWVTATNIRVRLTRLRTlgDELMDDRPEvTRRYYYAISDIAVGG 238
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 296-342 2.71e-07

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 46.96  E-value: 2.71e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 755504769 296 RCKCNLHATSCLY-DNSKLTCECEHNTTGPDCGKCKKNYQGRPWSPGS 342
Cdd:cd00055    1 PCDCNGHGSLSGQcDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGG 48
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 297-341 1.01e-04

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 40.03  E-value: 1.01e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 755504769  297 CKCNLHAT---SClyDNSKLTCECEHNTTGPDCGKCKKNYQGRPWSPG 341
Cdd:pfam00053   1 CDCNPHGSlsdTC--DPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPP 46
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 364-412 1.45e-04

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 39.26  E-value: 1.45e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 755504769 364 CECFGHSNRCSYIDLlNTVICVsCKHNTRGQHCELCRLGYFRNASAQLD 412
Cdd:cd00055    2 CDCNGHGSLSGQCDP-GTGQCE-CKPNTTGRRCDRCAPGYYGLPSQGGG 48
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 364-408 1.86e-03

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 36.18  E-value: 1.86e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 755504769  364 CECFGHSNRCSYIDLlNTVICVsCKHNTRGQHCELCRLGYFRNAS 408
Cdd:pfam00053   1 CDCNPHGSLSDTCDP-ETGQCL-CKPGVTGRHCDRCKPGYYGLPS 43
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
297-338 2.61e-03

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 35.75  E-value: 2.61e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 755504769   297 CKCNLHATSCLY-DNSKLTCECEHNTTGPDCGKCKKNYQGRPW 338
Cdd:smart00180   1 CDCDPGGSASGTcDPDTGQCECKPNVTGRRCDRCAPGYYGDGP 43
 
Name Accession Description Interval E-value
Laminin_N pfam00055
Laminin N-terminal (Domain VI);
50-295 2.32e-76

Laminin N-terminal (Domain VI);


Pssm-ID: 459653  Cd Length: 230  Bit Score: 239.41  E-value: 2.32e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755504769   50 CQPESTDMTKYLKVKldpPDITCG-DPPESFCAMGNP---YMCNnECDASTPELAHPPELMFDFEGRHPSTFWQSATWke 125
Cdd:pfam00055   1 CYPAFGNLAFGREVS---ATSTCGlNGPERYCILSGLeggKKCF-ICDSRDPHNSHPPSNLTDSNNGTNETWWQSETG-- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755504769  126 YPKPLQVNITLSWSKTIELTDnIVITFESGRPDQMILEKSLDYGRTWQPYQYYATDCLHAFHMDPKSVKDLSQHtvlEII 205
Cdd:pfam00055  75 VIQYENVNLTLDLGKEFHFTY-LILKFKSPRPAAMVLERSTDFGKTWQPYQYFASDCRRTFGRPSGPSRGIKDD---EVI 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755504769  206 CTEEYSTGY-STNSKIIhfeikdrFAFFAGPRLRNMAslygqlDTTKKLRDFFTVTDLRIRLLRPA--VGEIFVDELHLA 282
Cdd:pfam00055 151 CTSEYSDISpLTGGEVI-------FSTLEGRPSANIF------DYSPELQDWLTATNIRIRLLRLHtlGDELLDDPSVLR 217

                         250
                  ....*....|...
gi 755504769  283 RYFYAISDIKVRG 295
Cdd:pfam00055 218 KYYYAISDISVGG 230
LamNT smart00136
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related ...
 71-295 6.43e-40

Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related protein such as Unc-6/ netrins.


Pssm-ID: 214532  Cd Length: 238  Bit Score: 144.04  E-value: 6.43e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755504769    71 TCGDP-PESFCAMgNPYMCNNE----CDASTPELAHPPELMFDFEGRHPSTFWQSATWKEYPKplQVNITLSWSKTIELT 145
Cdd:smart00136  25 TCGEPgPERYCKL-VGHTEQGKkcdyCDARNPRRSHPAENLTDGNNPNNPTWWQSEPLSNGPQ--NVNLTLDLGKEFHVT 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755504769   146 dNIVITFESGRPDQMILEKSlDYGRTWQPYQYYATDCLHAFHMDPKSVKDLSQHTvlEIICTEEYS-TGYSTNSKIIHFE 224
Cdd:smart00136 102 -YVILKFCSPRPSLWILERS-DFGKTWQPWQYFSSDCRRTFGRPPRGPITKGNED--EVICTSEYSdIVPLEGGEIAFSL 177

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755504769   225 IKDRfaffagPRLRNmaslygqLDTTKKLRDFFTVTDLRIRLLRPAV--GEIFVDELH-LARYFYAISDIKVRG 295
Cdd:smart00136 178 LEGR------PSATD-------FDNSPVLQEWVTATNIRVRLTRLRTlgDELMDDRPEvTRRYYYAISDIAVGG 238
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 296-342 2.71e-07

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 46.96  E-value: 2.71e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 755504769 296 RCKCNLHATSCLY-DNSKLTCECEHNTTGPDCGKCKKNYQGRPWSPGS 342
Cdd:cd00055    1 PCDCNGHGSLSGQcDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGG 48
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 297-341 1.01e-04

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 40.03  E-value: 1.01e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 755504769  297 CKCNLHAT---SClyDNSKLTCECEHNTTGPDCGKCKKNYQGRPWSPG 341
Cdd:pfam00053   1 CDCNPHGSlsdTC--DPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPP 46
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 364-412 1.45e-04

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 39.26  E-value: 1.45e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 755504769 364 CECFGHSNRCSYIDLlNTVICVsCKHNTRGQHCELCRLGYFRNASAQLD 412
Cdd:cd00055    2 CDCNGHGSLSGQCDP-GTGQCE-CKPNTTGRRCDRCAPGYYGLPSQGGG 48
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 364-408 1.86e-03

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 36.18  E-value: 1.86e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 755504769  364 CECFGHSNRCSYIDLlNTVICVsCKHNTRGQHCELCRLGYFRNAS 408
Cdd:pfam00053   1 CDCNPHGSLSDTCDP-ETGQCL-CKPGVTGRHCDRCKPGYYGLPS 43
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
297-338 2.61e-03

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 35.75  E-value: 2.61e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 755504769   297 CKCNLHATSCLY-DNSKLTCECEHNTTGPDCGKCKKNYQGRPW 338
Cdd:smart00180   1 CDCDPGGSASGTcDPDTGQCECKPNVTGRRCDRCAPGYYGDGP 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH