Zinc-fingers and homeoboxes C2H2 finger domain; This is a C2H2 zinc-finger domain found in ZHX proteins such as ZHX1. ZHXs are multidomain proteins comprising two C2H2 zinc finger motifs and five homeodomains. Both homeodomains and zinc fingers are short protein modules involved in protein-DNA and/or protein-protein interactions; they are frequently associated with roles in transcriptional regulation. All members of the ZHX family are reported to be able to form both homo- and heterodimers via the region containing homeodomain 1. ZHX1 is a transcriptional repressor which is ubiquitously expressed. It interacts with nuclear factor Y subunit A (NFYA) and DNA methyl transferase 3B (DNMT3B) for its repression activity. Changes in expression profiles of rat ZHX1 ortholog have been associated with glomerular disease. In addition to the five homeodomains, ZHX1, which also contains of two N terminal C2H2 zincfingers forms homodimers via homeodomain and can also form heterodimers with ZHX3.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 755551873  106 LNPLYVCAECNFTTKKYDSLSDHNSKFHPGETNFKLKLIKRNNQTVLEQSIEA 158
Cdd:pfam18387   1 ADPSFVCVECGFSAKKFEGLALHNAESHPGETNFTLQVVKRDNQTTVEQSLVD 53

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 755551873 636 NQEQVHLLRSTFARTQWPTPQEYDQLAAKTGLVRTEIVRWFKENRCLLK 684
Cdd:cd00086    8 TPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLK 56

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 755551873 272 DTNATMINSFNKFPYPTQAELSWLTAASKHPEEHIRIWFATQRLKHGISW 321
Cdd:cd00086   10 EQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59

Zinc-fingers and homeoboxes C2H2 finger domain; This is a C2H2 zinc-finger domain found in ZHX proteins such as ZHX1. ZHXs are multidomain proteins comprising two C2H2 zinc finger motifs and five homeodomains. Both homeodomains and zinc fingers are short protein modules involved in protein-DNA and/or protein-protein interactions; they are frequently associated with roles in transcriptional regulation. All members of the ZHX family are reported to be able to form both homo- and heterodimers via the region containing homeodomain 1. ZHX1 is a transcriptional repressor which is ubiquitously expressed. It interacts with nuclear factor Y subunit A (NFYA) and DNA methyl transferase 3B (DNMT3B) for its repression activity. Changes in expression profiles of rat ZHX1 ortholog have been associated with glomerular disease. In addition to the five homeodomains, ZHX1, which also contains of two N terminal C2H2 zincfingers forms homodimers via homeodomain and can also form heterodimers with ZHX3.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 755551873  106 LNPLYVCAECNFTTKKYDSLSDHNSKFHPGETNFKLKLIKRNNQTVLEQSIEA 158
Cdd:pfam18387   1 ADPSFVCVECGFSAKKFEGLALHNAESHPGETNFTLQVVKRDNQTTVEQSLVD 53

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 755551873 636 NQEQVHLLRSTFARTQWPTPQEYDQLAAKTGLVRTEIVRWFKENRCLLK 684
Cdd:cd00086    8 TPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLK 56

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 755551873   444 RKKTKL---QIAHLKASFLQSQFPDDAEVYRLIEVTGLARSEIKKWFSDHRYRC 494
Cdd:smart00389   3 RKRTSFtpeQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKW 56

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 755551873 536 KSQGQLKTLEDSFLKSSFPTQAEVERLRVETKLSRREIDSWFSERRK 582
Cdd:cd00086    7 FTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRA 53

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 755551873 272 DTNATMINSFNKFPYPTQAELSWLTAASKHPEEHIRIWFATQRLKHGISW 321
Cdd:cd00086   10 EQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59

Homeodomain;

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 755551873  637 QEQVHLLRSTFARTQWPTPQEYDQLAAKTGLVRTEIVRWFKeNR 680
Cdd:pfam00046   9 PEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQ-NR 51

Zinc-fingers and homeoboxes C2H2 finger domain; This is a C2H2 zinc-finger domain found in ZHX proteins such as ZHX1. ZHXs are multidomain proteins comprising two C2H2 zinc finger motifs and five homeodomains. Both homeodomains and zinc fingers are short protein modules involved in protein-DNA and/or protein-protein interactions; they are frequently associated with roles in transcriptional regulation. All members of the ZHX family are reported to be able to form both homo- and heterodimers via the region containing homeodomain 1. ZHX1 is a transcriptional repressor which is ubiquitously expressed. It interacts with nuclear factor Y subunit A (NFYA) and DNA methyl transferase 3B (DNMT3B) for its repression activity. Changes in expression profiles of rat ZHX1 ortholog have been associated with glomerular disease. In addition to the five homeodomains, ZHX1, which also contains of two N terminal C2H2 zincfingers forms homodimers via homeodomain and can also form heterodimers with ZHX3.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 755551873  106 LNPLYVCAECNFTTKKYDSLSDHNSKFHPGETNFKLKLIKRNNQTVLEQSIEA 158
Cdd:pfam18387   1 ADPSFVCVECGFSAKKFEGLALHNAESHPGETNFTLQVVKRDNQTTVEQSLVD 53

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 755551873 636 NQEQVHLLRSTFARTQWPTPQEYDQLAAKTGLVRTEIVRWFKENRCLLK 684
Cdd:cd00086    8 TPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLK 56

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 755551873   444 RKKTKL---QIAHLKASFLQSQFPDDAEVYRLIEVTGLARSEIKKWFSDHRYRC 494
Cdd:smart00389   3 RKRTSFtpeQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKW 56

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 755551873 536 KSQGQLKTLEDSFLKSSFPTQAEVERLRVETKLSRREIDSWFSERRK 582
Cdd:cd00086    7 FTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRA 53

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 755551873 272 DTNATMINSFNKFPYPTQAELSWLTAASKHPEEHIRIWFATQRLKHGISW 321
Cdd:cd00086   10 EQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59

Homeodomain;

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 755551873  637 QEQVHLLRSTFARTQWPTPQEYDQLAAKTGLVRTEIVRWFKeNR 680
Cdd:pfam00046   9 PEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQ-NR 51

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.

                          10        20
                  ....*....|....*....|....
gi 755551873  653 PTPQEYDQLAAKTGLVRTEIVRWF 676
Cdd:pfam05920  10 PSEEEKAELAKETGLSRKQISNWF 33