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Conserved domains on  [gi|755553586|ref|XP_011244208|]
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protein NLRC3 isoform X5 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1908381)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RNA1 super family cl34950
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 2-276 1.10e-54

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG5238:

Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 187.69  E-value: 1.10e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553586   2 AGRLDNNQFQDPVMELLGSVLSGKDCRIRKISLAENQIGNKGAKALARSLLVNRSLITLDLRSNSIGPPGAKALADALKI 81
Cdd:COG5238  155 AVHLLGLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKG 234

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553586  82 NRTLTSLSLQSNVIKDDGVMCVAEALVSNQTISMLQLQKNLIGLIGAQQMADALKQNRSLKALMFSSNTIGDRGAIALAE 161
Cdd:COG5238  235 NKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAE 314

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553586 162 ALKVNQILENLDLQSNSISDMGVTVLMRALCSNQTLSSLNLRENSISPEGAQALTQALCRNNTLKHLDLTANLLHDRGAQ 241
Cdd:COG5238  315 GLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAE 394

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 755553586 242 AIAVAVGENhSLTHLHLQWNFIQAGAARALGQALQ 276
Cdd:COG5238  395 ALIDALQTN-RLHTLILDGNLIGAEAQQRLEQLLE 428
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 171-428 4.29e-22

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd00116:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 319  Bit Score: 96.27  E-value: 4.29e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553586 171 NLDLQSNSISDMGVTVLMRALcsnQTLSSLNLRENSISPEGAQALTQALCRNNTLKHLDLTANLL--HDRGAQAIAVAVG 248
Cdd:cd00116    2 QLSLKGELLKTERATELLPKL---LCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETgrIPRGLQSLLQGLT 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553586 249 ENHSLTHLHLQWNFIQAGAARALgQALQLNRTLTTLDLQENAIGDEGASSVAGALK-VNTTLIALYLQVASIGSQGAQAL 327
Cdd:cd00116   79 KGCGLQELDLSDNALGPDGCGVL-ESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKdLPPALEKLVLGRNRLEGASCEAL 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553586 328 GEALTVNRTLEILELltcpdslRGNDVGAAGAKALANALKLNSSLRRLNLQENSLGMDGAIFVASALSENHGLHHINLQG 407
Cdd:cd00116  158 AKALRANRDLKELNL-------ANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGD 230

                        250       260
                 ....*....|....*....|.
gi 755553586 408 NPIGESAARMISEAIKTNAPT 428
Cdd:cd00116  231 NNLTDAGAAALASALLSPNIS 251
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 2-276 1.10e-54

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 187.69  E-value: 1.10e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553586   2 AGRLDNNQFQDPVMELLGSVLSGKDCRIRKISLAENQIGNKGAKALARSLLVNRSLITLDLRSNSIGPPGAKALADALKI 81
Cdd:COG5238  155 AVHLLGLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKG 234

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553586  82 NRTLTSLSLQSNVIKDDGVMCVAEALVSNQTISMLQLQKNLIGLIGAQQMADALKQNRSLKALMFSSNTIGDRGAIALAE 161
Cdd:COG5238  235 NKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAE 314

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553586 162 ALKVNQILENLDLQSNSISDMGVTVLMRALCSNQTLSSLNLRENSISPEGAQALTQALCRNNTLKHLDLTANLLHDRGAQ 241
Cdd:COG5238  315 GLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAE 394

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 755553586 242 AIAVAVGENhSLTHLHLQWNFIQAGAARALGQALQ 276
Cdd:COG5238  395 ALIDALQTN-RLHTLILDGNLIGAEAQQRLEQLLE 428
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 116-421 4.99e-36

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 134.79  E-value: 4.99e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553586 116 LQLQKNLIGLIGAQQMADALKQnrsLKALMFSSNTIGDRGAIALAEALKVNQILENLDLQSNSI--SDMGVTVLMRALCS 193
Cdd:cd00116    3 LSLKGELLKTERATELLPKLLC---LQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETgrIPRGLQSLLQGLTK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553586 194 NQTLSSLNLRENSISPEGAQALtQALCRNNTLKHLDLTANLLHDRGAQAIAVAVGEN-HSLTHLHLQWNFIQAGAARALG 272
Cdd:cd00116   80 GCGLQELDLSDNALGPDGCGVL-ESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLpPALEKLVLGRNRLEGASCEALA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553586 273 QALQLNRTLTTLDLQENAIGDEGASSVAGALKVNTTLIALYLQVASIGSQGAQALGEALTVNRTLEILELLTCPDSLRGn 352
Cdd:cd00116  159 KALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAG- 237

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755553586 353 dvgaaGAKALANALKLNSSLRRLNLQENSLGMDGAIFVASALSENHGLHHINLQGNPIGESAARMISEA 421
Cdd:cd00116  238 -----AAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAES 301
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 171-428 4.29e-22

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 96.27  E-value: 4.29e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553586 171 NLDLQSNSISDMGVTVLMRALcsnQTLSSLNLRENSISPEGAQALTQALCRNNTLKHLDLTANLL--HDRGAQAIAVAVG 248
Cdd:cd00116    2 QLSLKGELLKTERATELLPKL---LCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETgrIPRGLQSLLQGLT 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553586 249 ENHSLTHLHLQWNFIQAGAARALgQALQLNRTLTTLDLQENAIGDEGASSVAGALK-VNTTLIALYLQVASIGSQGAQAL 327
Cdd:cd00116   79 KGCGLQELDLSDNALGPDGCGVL-ESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKdLPPALEKLVLGRNRLEGASCEAL 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553586 328 GEALTVNRTLEILELltcpdslRGNDVGAAGAKALANALKLNSSLRRLNLQENSLGMDGAIFVASALSENHGLHHINLQG 407
Cdd:cd00116  158 AKALRANRDLKELNL-------ANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGD 230

                        250       260
                 ....*....|....*....|.
gi 755553586 408 NPIGESAARMISEAIKTNAPT 428
Cdd:cd00116  231 NNLTDAGAAALASALLSPNIS 251
LRR_6 pfam13516
Leucine Rich repeat;
278-300 1.08e-03

Leucine Rich repeat;


Pssm-ID: 463907 [Multi-domain]  Cd Length: 24  Bit Score: 36.06  E-value: 1.08e-03
                          10        20
                  ....*....|....*....|...
gi 755553586  278 NRTLTTLDLQENAIGDEGASSVA 300
Cdd:pfam13516   2 NTHLTTLDLSDNDIGDEGAEALA 24
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
54-80 2.39e-03

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 35.08  E-value: 2.39e-03
                           10        20
                   ....*....|....*....|....*..
gi 755553586    54 NRSLITLDLRSNSIGPPGAKALADALK 80
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALK 27
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 2-276 1.10e-54

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 187.69  E-value: 1.10e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553586   2 AGRLDNNQFQDPVMELLGSVLSGKDCRIRKISLAENQIGNKGAKALARSLLVNRSLITLDLRSNSIGPPGAKALADALKI 81
Cdd:COG5238  155 AVHLLGLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKG 234

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553586  82 NRTLTSLSLQSNVIKDDGVMCVAEALVSNQTISMLQLQKNLIGLIGAQQMADALKQNRSLKALMFSSNTIGDRGAIALAE 161
Cdd:COG5238  235 NKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAE 314

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553586 162 ALKVNQILENLDLQSNSISDMGVTVLMRALCSNQTLSSLNLRENSISPEGAQALTQALCRNNTLKHLDLTANLLHDRGAQ 241
Cdd:COG5238  315 GLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAE 394

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 755553586 242 AIAVAVGENhSLTHLHLQWNFIQAGAARALGQALQ 276
Cdd:COG5238  395 ALIDALQTN-RLHTLILDGNLIGAEAQQRLEQLLE 428
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 88-335 2.35e-49

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 173.44  E-value: 2.35e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553586  88 LSLQSNVIKDDGVMCVAEALvSNQTISMLQLQKNLIGLIGAQQMADALKQNRSLKALMFSSNTIGDRGAIALAEALKVNQ 167
Cdd:COG5238  158 LLGLAARLGLLAAISMAKAL-QNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNK 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553586 168 ILENLDLQSNSISDMGVTVLMRALCSNQTLSSLNLRENSISPEGAQALTQALCRNNTLKHLDLTANLLHDRGAQAIAVAV 247
Cdd:COG5238  237 SLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGL 316

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553586 248 GENHSLTHLHLQWNFIQAGAARALGQALQLNRTLTTLDLQENAIGDEGASSVAGALKVNTTLIALYLQVASIGSQGAQAL 327
Cdd:COG5238  317 QGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEAL 396


                 ....*...
gi 755553586 328 GEALTVNR 335
Cdd:COG5238  397 IDALQTNR 404
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 27-425 2.58e-42

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 154.56  E-value: 2.58e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553586  27 CRIRKISLAENQIGNKGAKALARSLlVNRSLITLDLRSNSIGPPGAKALADALKINRTLTSLsLQSNVIKDDGVMCVAEA 106
Cdd:COG5238   29 TKRATIVNLRSYHLHGGAILLARYL-QSRSSITQYLRFEGQGDPGLNPVALEKAAEAFPTQL-LVVDWEGAEEVSPVALA 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553586 107 L---------------VSNQTISMLQLQKNLIGLIGAQQMADALKQNRSLKALMFSsNTIGDRGAIALAEALKvNQILEN 171
Cdd:COG5238  107 EtatavatpppdlrriMAKTLEDSLILYLALPRRINLIQVLKDPLGGNAVHLLGLA-ARLGLLAAISMAKALQ-NNSVET 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553586 172 LDLQSNSISDMGVTVLMRALCSNQTLSSLNLRENSISPEGAQALTQALCRNNTLKHLDLTANLLHDRGAQAIAVAVGENH 251
Cdd:COG5238  185 VYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNT 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553586 252 SLTHLHLQWNFIQAGAARALGQALQLNRTLTTLDLQENAIGDEGASSVAGALKVNTTLIALYLQVASIGSQGAQALgeal 331
Cdd:COG5238  265 TVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIAL---- 340

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553586 332 tvnrtleilelltcpdslrgndvgaagakalANALKLNSSLRRLNLQENSLGMDGAIFVASALSENHGLHHINLQGNPIG 411
Cdd:COG5238  341 -------------------------------AKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIG 389

                        410
                 ....*....|....
gi 755553586 412 ESAARMISEAIKTN 425
Cdd:COG5238  390 KQGAEALIDALQTN 403
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 116-421 4.99e-36

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 134.79  E-value: 4.99e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553586 116 LQLQKNLIGLIGAQQMADALKQnrsLKALMFSSNTIGDRGAIALAEALKVNQILENLDLQSNSI--SDMGVTVLMRALCS 193
Cdd:cd00116    3 LSLKGELLKTERATELLPKLLC---LQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETgrIPRGLQSLLQGLTK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553586 194 NQTLSSLNLRENSISPEGAQALtQALCRNNTLKHLDLTANLLHDRGAQAIAVAVGEN-HSLTHLHLQWNFIQAGAARALG 272
Cdd:cd00116   80 GCGLQELDLSDNALGPDGCGVL-ESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLpPALEKLVLGRNRLEGASCEALA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553586 273 QALQLNRTLTTLDLQENAIGDEGASSVAGALKVNTTLIALYLQVASIGSQGAQALGEALTVNRTLEILELLTCPDSLRGn 352
Cdd:cd00116  159 KALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAG- 237

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755553586 353 dvgaaGAKALANALKLNSSLRRLNLQENSLGMDGAIFVASALSENHGLHHINLQGNPIGESAARMISEA 421
Cdd:cd00116  238 -----AAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAES 301
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 34-347 8.11e-34

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 128.63  E-value: 8.11e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553586  34 LAENQIGNKGAKALARSLLVNRSLITLDLRSNSIG--PPGAKALADALKINRTLTSLSLQSNVIKDDGVMCVaEALVSNQ 111
Cdd:cd00116   30 LEGNTLGEEAAKALASALRPQPSLKELCLSLNETGriPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVL-ESLLRSS 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553586 112 TISMLQLQKNLIGLIGAQQMADALKQNR-SLKALMFSSNTIGDRGAIALAEALKVNQILENLDLQSNSISDMGVTVLMRA 190
Cdd:cd00116  109 SLQELKLNNNGLGDRGLRLLAKGLKDLPpALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEG 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553586 191 LCSNQTLSSLNLRENSISPEGAQALTQALCRNNTLKHLDLTANLLHDRGAQAIAVAVgenhslthlhlqwnfiqagaara 270
Cdd:cd00116  189 LKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASAL----------------------- 245

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755553586 271 lgqaLQLNRTLTTLDLQENAIGDEGASSVAGALKVNTTLIALYLQVASIGSQGAQALGEALTVNR-TLEILELLTCPD 347
Cdd:cd00116  246 ----LSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGnELESLWVKDDSF 319
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 32-279 2.11e-29

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 116.69  E-value: 2.11e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553586  32 ISLAENQIGNKGAKALARSLLVNRSLITLDLRSNSIGPPGAKALADALKiNRTLTSLSLQSNVIKDDGVMCVAEALVSNQ 111
Cdd:cd00116   58 LSLNETGRIPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVLESLLR-SSSLQELKLNNNGLGDRGLRLLAKGLKDLP 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553586 112 -TISMLQLQKNLIGLIGAQQMADALKQNRSLKALMFSSNTIGDRGAIALAEALKVNQILENLDLQSNSISDMGVTVLMRA 190
Cdd:cd00116  137 pALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAET 216

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553586 191 LCSNQTLSSLNLRENSISPEGAQAL-TQALCRNNTLKHLDLTANLLHDRGAQAIAVAVGENHSLTHLHLQWNFIQAGAAR 269
Cdd:cd00116  217 LASLKSLEVLNLGDNNLTDAGAAALaSALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQ 296

                        250
                 ....*....|
gi 755553586 270 ALGQALQLNR 279
Cdd:cd00116  297 LLAESLLEPG 306
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 5-187 7.07e-26

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 107.06  E-value: 7.07e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553586   5 LDNNQFQDPVMELLGSVLSGKDCRIRKISLAENQIGNKGAKALARSLLVNRSLITLDLRSNSIGPPGAKALADALKINRT 84
Cdd:cd00116  115 LNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCN 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553586  85 LTSLSLQSNVIKDDGVMCVAEALVSNQTISMLQLQKNLIGLIGAQQMADALKQ-NRSLKALMFSSNTIGDRGAIALAEAL 163
Cdd:cd00116  195 LEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSpNISLLTLSLSCNDITDDGAKDLAEVL 274

                        170       180
                 ....*....|....*....|....
gi 755553586 164 KVNQILENLDLQSNSISDMGVTVL 187
Cdd:cd00116  275 AEKESLLELDLRGNKFGEEGAQLL 298
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 171-428 4.29e-22

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 96.27  E-value: 4.29e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553586 171 NLDLQSNSISDMGVTVLMRALcsnQTLSSLNLRENSISPEGAQALTQALCRNNTLKHLDLTANLL--HDRGAQAIAVAVG 248
Cdd:cd00116    2 QLSLKGELLKTERATELLPKL---LCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETgrIPRGLQSLLQGLT 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553586 249 ENHSLTHLHLQWNFIQAGAARALgQALQLNRTLTTLDLQENAIGDEGASSVAGALK-VNTTLIALYLQVASIGSQGAQAL 327
Cdd:cd00116   79 KGCGLQELDLSDNALGPDGCGVL-ESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKdLPPALEKLVLGRNRLEGASCEAL 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553586 328 GEALTVNRTLEILELltcpdslRGNDVGAAGAKALANALKLNSSLRRLNLQENSLGMDGAIFVASALSENHGLHHINLQG 407
Cdd:cd00116  158 AKALRANRDLKELNL-------ANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGD 230

                        250       260
                 ....*....|....*....|.
gi 755553586 408 NPIGESAARMISEAIKTNAPT 428
Cdd:cd00116  231 NNLTDAGAAALASALLSPNIS 251
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
85-340 1.60e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.85  E-value: 1.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553586  85 LTSLSLQSNVIKDdgvmcVAEALVSNQTISMLQLQKNLIGLIGaqqmaDALKQNRSLKALMFSSNTIGDrgaiaLAEALK 164
Cdd:COG4886  115 LESLDLSGNQLTD-----LPEELANLTNLKELDLSNNQLTDLP-----EPLGNLTNLKSLDLSNNQLTD-----LPEELG 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553586 165 VNQILENLDLQSNSISDMGVtvlmrALCSNQTLSSLNLRENSISpegaqALTQALCRNNTLKHLDLTANLLHDrgaqaiA 244
Cdd:COG4886  180 NLTNLKELDLSNNQITDLPE-----PLGNLTNLEELDLSGNQLT-----DLPEPLANLTNLETLDLSNNQLTD------L 243

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553586 245 VAVGENHSLTHLHLQWNFIqagaaRALGQALQLNRtLTTLDLQENAIGDEGASSVAGALKVNTTLIALYLQVASIGSQGA 324
Cdd:COG4886  244 PELGNLTNLEELDLSNNQL-----TDLPPLANLTN-LKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILL 317

                        250
                 ....*....|....*.
gi 755553586 325 QALGEALTVNRTLEIL 340
Cdd:COG4886  318 LLLTTLLLLLLLLKGL 333
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
29-344 5.39e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 45.31  E-value: 5.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553586  29 IRKISLAENQIgnkgaKALARSLLVNRSLITLDLRSNSIgppgaKALADALKINRTLTSLSLQSNVIKDdgvmcVAEALV 108
Cdd:COG4886  115 LESLDLSGNQL-----TDLPEELANLTNLKELDLSNNQL-----TDLPEPLGNLTNLKSLDLSNNQLTD-----LPEELG 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553586 109 SNQTISMLQLQKNLIgligaQQMADALKQNRSLKALMFSSNTIGDrgaiaLAEALKVNQILENLDLQSNSISDMgvtvlm 188
Cdd:COG4886  180 NLTNLKELDLSNNQI-----TDLPEPLGNLTNLEELDLSGNQLTD-----LPEPLANLTNLETLDLSNNQLTDL------ 243

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553586 189 RALCSNQTLSSLNLRENSIS--PEGAQaltqalcrNNTLKHLDLTANLLHDRGAQAIAVAVGENHSLTHLHLQWNFIQAG 266
Cdd:COG4886  244 PELGNLTNLEELDLSNNQLTdlPPLAN--------LTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLI 315

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755553586 267 AARALGQALQLNRTLTTLDLQENAIGDEGASSVAGALKVNTTLIALYLQVASIGSQGAQALGEALTVNRTLEILELLT 344
Cdd:COG4886  316 LLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLL 393
LRR_6 pfam13516
Leucine Rich repeat;
278-300 1.08e-03

Leucine Rich repeat;


Pssm-ID: 463907 [Multi-domain]  Cd Length: 24  Bit Score: 36.06  E-value: 1.08e-03
                          10        20
                  ....*....|....*....|...
gi 755553586  278 NRTLTTLDLQENAIGDEGASSVA 300
Cdd:pfam13516   2 NTHLTTLDLSDNDIGDEGAEALA 24
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
54-80 2.39e-03

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 35.08  E-value: 2.39e-03
                           10        20
                   ....*....|....*....|....*..
gi 755553586    54 NRSLITLDLRSNSIGPPGAKALADALK 80
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALK 27
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 55-233 3.67e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.61  E-value: 3.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553586  55 RSLITLDLRSNSIgppgakALADALKINRTLTSLSLQSNVIKddgVMCVAEALV-------SNQTISM---LQLQKNLIG 124
Cdd:cd21340   24 KNLKVLYLYDNKI------TKIENLEFLTNLTHLYLQNNQIE---KIENLENLVnlkklylGGNRISVvegLENLTNLEE 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553586 125 L-IGAQQMADALKqnrslkaLMFSSNTIgdrgaIALAEALKVnqilenLDLQSNSISDMGVTVLMRALcsnqtlSSLNLR 203
Cdd:cd21340   95 LhIENQRLPPGEK-------LTFDPRSL-----AALSNSLRV------LNISGNNIDSLEPLAPLRNL------EQLDAS 150

                        170       180       190
                 ....*....|....*....|....*....|
gi 755553586 204 ENSISpeGAQALTQALCRNNTLKHLDLTAN 233
Cdd:cd21340  151 NNQIS--DLEELLDLLSSWPSLRELDLTGN 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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