WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755562716 204 SKGVYCLQYDD--QKIVSGLRDNTIKIWDKSTLECKRILTGHTGSVLCLQY--DERVIITGSSDSTVRVWDVNAGEMLNT 279
Cdd:cd00200    9 TGGVTCVAFSPdgKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAsaDGTYLASGSSDKTIRLWDLETGECVRT 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755562716 280 LIHHCEAVLHLRF--NNGMMVTCSKDRSIAVWDMASPtdiTLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTS 355
Cdd:cd00200   89 LTGHTSYVSSVAFspDGRILSSSSRDKTIKVWDVETG---KCLTTLRGHTDWVNSVAFspDGTFVASSSQDGTIKLWDLR 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755562716 356 TCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKR--IVSGAYDGKIKV 431
Cdd:cd00200  166 TGKCVATLTGHTGEVNSVAFSPdgEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGylLASGSEDGTIRV 245

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 755562716 432 WDLMAAldprapagtLCLRTLVEHSGRVFRLQF--DEFQIVSSSHDDTILIWD 482
Cdd:cd00200  246 WDLRTG---------ECVQTLSGHTNSVTSLAWspDGKRLASGSADGTIRIWD 289

D domain of beta-TrCP; This domain is found in eukaryotes, and is approximately 40 amino acids in length. It is found associated with pfam00646, pfam00400. The protein that contains this domain functions as a ubiquitin ligase. Ubiquitination is required to direct proteins towards the proteasome for degradation. This protein is part of the WD40 class of F box proteins. The D domain of these F box proteins is involved in mediating the dimerization of the protein. dimerization is necessary to polyubiquitinate substrates so this D domain is vital in directing substrates towards the proteasome for degradation.

                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 755562716   40 KYFEQWSESDQVEFVEHLISQMCHYQHGHINSYLKPMLQ 78
Cdd:pfam12125   1 KYFDKWNESDQVDFVEHLLSRMCHYQHGHINSYLKPMLQ 39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755562716 204 SKGVYCLQYDD--QKIVSGLRDNTIKIWDKSTLECKRILTGHTGSVLCLQY--DERVIITGSSDSTVRVWDVNAGEMLNT 279
Cdd:cd00200    9 TGGVTCVAFSPdgKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAsaDGTYLASGSSDKTIRLWDLETGECVRT 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755562716 280 LIHHCEAVLHLRF--NNGMMVTCSKDRSIAVWDMASPtdiTLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTS 355
Cdd:cd00200   89 LTGHTSYVSSVAFspDGRILSSSSRDKTIKVWDVETG---KCLTTLRGHTDWVNSVAFspDGTFVASSSQDGTIKLWDLR 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755562716 356 TCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKR--IVSGAYDGKIKV 431
Cdd:cd00200  166 TGKCVATLTGHTGEVNSVAFSPdgEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGylLASGSEDGTIRV 245

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 755562716 432 WDLMAAldprapagtLCLRTLVEHSGRVFRLQF--DEFQIVSSSHDDTILIWD 482
Cdd:cd00200  246 WDLRTG---------ECVQTLSGHTNSVTSLAWspDGKRLASGSADGTIRIWD 289

F-box domain found in F-box/WD repeat-containing protein 1A (FBXW1A) and similar proteins; FBXW1A, also called E3RSIkappaB, epididymis tissue protein Li 2a, F-box and WD repeats protein beta-TrCP, or pIkappaBalpha-E3 receptor subunit, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as CTNNB1, NFKBIA, NFKBIB and NFKBIE, as well as phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 755562716  76 MLQRDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVR 135
Cdd:cd22182    1 MLQRDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVR 60

D domain of beta-TrCP; This domain is found in eukaryotes, and is approximately 40 amino acids in length. It is found associated with F-box domain, WD domain. The protein that contains this domain functions as a ubiquitin ligase. Ubiquitination is required to direct proteins towards the proteasome for degradation. This protein is part of the WD40 class of F box proteins. The D domain of these F box proteins is involved in mediating the dimerisation of the protein. Dimerisation is necessary to polyubiquitinate substrates so this D domain is vital in directing substrates towards the proteasome for degradation.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 755562716    39 VKYFEQWSESDQVEFVEHLISQMCHYQHGHINSYLKPMLQ 78
Cdd:smart01028   1 VKYFEKWSESDQVDFVEHLISRMCHYQHGHINSYLKPMLQ 40

F-box-like; This is an F-box-like family.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 755562716   82 ITALParglDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKL 129
Cdd:pfam12937   1 LSSLP----DEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLWRRL 44

A Receptor for Ubiquitination Targets;

                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 755562716    91 DHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKL 129
Cdd:smart00256   3 DEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755562716 204 SKGVYCLQYDD--QKIVSGLRDNTIKIWDKSTLECKRILTGHTGSVLCLQY--DERVIITGSSDSTVRVWDVNAGEMLNT 279
Cdd:cd00200    9 TGGVTCVAFSPdgKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAsaDGTYLASGSSDKTIRLWDLETGECVRT 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755562716 280 LIHHCEAVLHLRF--NNGMMVTCSKDRSIAVWDMASPtdiTLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTS 355
Cdd:cd00200   89 LTGHTSYVSSVAFspDGRILSSSSRDKTIKVWDVETG---KCLTTLRGHTDWVNSVAFspDGTFVASSSQDGTIKLWDLR 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755562716 356 TCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKR--IVSGAYDGKIKV 431
Cdd:cd00200  166 TGKCVATLTGHTGEVNSVAFSPdgEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGylLASGSEDGTIRV 245

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 755562716 432 WDLMAAldprapagtLCLRTLVEHSGRVFRLQF--DEFQIVSSSHDDTILIWD 482
Cdd:cd00200  246 WDLRTG---------ECVQTLSGHTNSVTSLAWspDGKRLASGSADGTIRIWD 289

WD40 repeat [General function prediction only];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755562716 204 SKGVYCLQY--DDQKIVSGLRDNTIKIWDKSTLECKRILTGHTGSVLCLQY--DERVIITGSSDSTVRVWDVNAGEMLNT 279
Cdd:COG2319  162 SGAVTSVAFspDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFspDGKLLASGSADGTVRLWDLATGKLLRT 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755562716 280 LIHHCEAVLHLRFN-NG-MMVTCSKDRSIAVWDMASPTditLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTS 355
Cdd:COG2319  242 LTGHSGSVRSVAFSpDGrLLASGSADGTVRLWDLATGE---LLRTLTGHSGGVNSVAFspDGKLLASGSDDGTVRLWDLA 318

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755562716 356 TCEFVRTLNGHKRGIACLQYR--DRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKV 431
Cdd:COG2319  319 TGKLLRTLTGHTGAVRSVAFSpdGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFspDGRTLASGSADGTVRL 398

                 ...
gi 755562716 432 WDL 434
Cdd:COG2319  399 WDL 401

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755562716 236 CKRILTGHTGSVLCLQY--DERVIITGSSDSTVRVWDVNAGEMLntlihhceavlhlrfnngmmvtcskdrsiavwdmas 313
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFspDGKLLATGSGDGTIKVWDLETGELL------------------------------------ 44

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755562716 314 ptditlrRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYR--DRLVVSGSSDNTI 389
Cdd:cd00200   45 -------RTLKGHTGPVRDVAAsaDGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSpdGRILSSSSRDKTI 117

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755562716 390 RLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLmaaldprapAGTLCLRTLVEHSGRVFRLQF--D 465
Cdd:cd00200  118 KVWDVETGKCLTTLRGHTDWVNSVAFspDGTFVASSSQDGTIKLWDL---------RTGKCVATLTGHTGEVNSVAFspD 188

                        250
                 ....*....|....*...
gi 755562716 466 EFQIVSSSHDDTILIWDF 483
Cdd:cd00200  189 GEKLLSSSSDGTIKLWDL 206

WD40 repeat [General function prediction only];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755562716 195 QRIHCRSETSKGVYCLQY--DDQKIVSGLRDNTIKIWDKSTLECKRILTGHTGSVLCLQY--DERVIITGSSDSTVRVWD 270
Cdd:COG2319  237 KLLRTLTGHSGSVRSVAFspDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFspDGKLLASGSDDGTVRLWD 316

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755562716 271 VNAGEMLNTLIHHCEAVLHLRF--NNGMMVTCSKDRSIAVWDMASPTditLRRVLVGHRAAVNVVDF--DDKYIVSASGD 346
Cdd:COG2319  317 LATGKLLRTLTGHTGAVRSVAFspDGKTLASGSDDGTVRLWDLATGE---LLRTLTGHTGAVTSVAFspDGRTLASGSAD 393

                        170
                 ....*....|
gi 755562716 347 RTIKVWNTST 356
Cdd:COG2319  394 GTVRLWDLAT 403

F-box domain found in F-box/WD repeat-containing proteins, FBXW1A, FBXW1B and similar proteins; FBXW1A, also called E3RSIkappaB, epididymis tissue protein Li 2a, F-box and WD repeats protein beta-TrCP, or pIkappaBalpha-E3 receptor subunit, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as CTNNB1, NFKBIA, NFKBIB and NFKBIE, as well as phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. FBXW1B, also called F-box/WD repeat-containing protein 11 (FBXW11), F-box and WD repeats protein beta-TrCP2, or homologous to Slimb protein (HOS), is the substrate-recognition component of an SCF E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as IFNAR1, CEP68 and CDC25A, as well as phosphorylated CTNNB1, NFKBIA, PER1 and PER2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 755562716  78 QRDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKK 128
Cdd:cd22130    1 QRDFISALPAKGLDHIAENILSYLDAKSLCAAELVCKEWYRVIADGMLWKK 51

D domain of beta-TrCP; This domain is found in eukaryotes, and is approximately 40 amino acids in length. It is found associated with pfam00646, pfam00400. The protein that contains this domain functions as a ubiquitin ligase. Ubiquitination is required to direct proteins towards the proteasome for degradation. This protein is part of the WD40 class of F box proteins. The D domain of these F box proteins is involved in mediating the dimerization of the protein. dimerization is necessary to polyubiquitinate substrates so this D domain is vital in directing substrates towards the proteasome for degradation.

                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 755562716   40 KYFEQWSESDQVEFVEHLISQMCHYQHGHINSYLKPMLQ 78
Cdd:pfam12125   1 KYFDKWNESDQVDFVEHLLSRMCHYQHGHINSYLKPMLQ 39

protein SPA1-RELATED; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755562716 340 IVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRD---RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVrCIRFD 416
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSadpTLLASGSDDGSVKLWSINQGVSIGTIKTKANIC-CVQFP 626

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755562716 417 N---KRIVSGAYDGKIKVWDLmaaldpRAPAGTLClrTLVEHSGRVFRLQF-DEFQIVSSSHDDTILIWDFLNDPAAHAE 492
Cdd:PLN00181 627 SesgRSLAFGSADHKVYYYDL------RNPKLPLC--TMIGHSKTVSYVRFvDSSTLVSSSTDNTLKLWDLSMSISGINE 698

                 ..
gi 755562716 493 PP 494
Cdd:PLN00181 699 TP 700

F-box-like; This is an F-box-like family.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 755562716   82 ITALParglDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKL 129
Cdd:pfam12937   1 LSSLP----DEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLWRRL 44

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 755562716   233 TLECKRILTGHTGSVLCLQY--DERVIITGSSDSTVRVWD 270
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFspDGKYLASGSDDGTIKLWD 40

F-box domain found in F-box/WD repeat-containing protein 7 (FBXW7) and similar proteins; FBXW7, also called Archipelago homolog (Ago), F-box and WD-40 domain-containing protein 7, F-box protein FBX30, SEL-10, or Cdc4, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, and probably PSEN1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 755562716  68 HINSYLKPMLQRDFITALPARgldhIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWK 127
Cdd:cd22133    4 HMMQVIEPQFQRDFISLLPKE----LALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWR 59

WD domain, G-beta repeat;

                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 755562716  397 GACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWD 433
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFspDGKLLASGSDDGTVKVWD 39

F-box domain found in Dictyostelium discoideum Rho GTPase-activating protein gacFF (DdgacFF) and similar proteins; DdgacFF, also called GTPase activating factor for raC protein FF, is a Rho GTPase-activating protein involved in the signal transduction pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 755562716  81 FITALParglDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWK 127
Cdd:cd22148    1 FISLLP----EHLALKILSYLSPKELLIASQVSKTWRRLASSNELWK 43

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.

                         10        20        30
                 ....*....|....*....|....*....|.
gi 755562716  91 DHIAENILSYLDAKSLCAAELVCKEWYRVTS 121
Cdd:cd09917    5 DEILLKILSYLDPRDLLRLSLVCKRWRELAS 35

F-box domain found in F-box only protein 41 (FBXO41) and similar proteins; FBXO41, also called FBX41, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a novel central nervous system (CNS)-specific F-box protein that localizes to the centrosome and the cytoplasm of neurons and promotes neuronal migration. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 755562716  84 ALPARGLDHIaenILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKL 129
Cdd:cd22109    4 SLRRRDALFC---VFSYLDTKSLLRCAEVCREWRDVSRHPALWQRV 46

F-box domain found in F-box only protein 11 (FBXO11) and similar proteins; FBXO11, also called FBX11, protein arginine N-methyltransferase 9 (PRMT9), or vitiligo-associated protein 1 (VIT-1), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 755562716  91 DHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKL 129
Cdd:cd22091    6 DEVLLKIFSYLLEQDLCRAAQVCKRFNTLANDPELWKRL 44

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.

                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 755562716   318 TLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWN 353
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFspDGKYLASGSDDGTIKLWD 40

WD domain, G-beta repeat;

                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 755562716  318 TLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWN 353
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFspDGKLLASGSDDGTVKVWD 39

F-box domain found in epithelial cell-transforming sequence 2 oncogene-like (ECT2L) and similar proteins; ECT2L, also called lung-specific F-box and DH domain-containing protein, or putative guanine nucleotide exchange factor LFDH, may act as a guanine nucleotide exchange factor (GEF). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755562716  80 DFITALPArgldHIAENILSYLDAKSLCAAELVCkeWYrvtsdgmlWKKLIERmvrtDSLWRGLAERRGW 149
Cdd:cd22173    1 DFTTVLPR----FLSLYIFSFLDPRSLCRAAQVS--WH--------WKFLAEQ----DCLWMPKCVKFGW 52

F-box domain found in F-box/WD repeat-containing protein 2 (FBXW2) and similar proteins; FBXW2, also called F-box and WD-40 domain-containing protein 2, or protein MD6, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a tumor suppressor by promoting SKP2 degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 755562716  80 DFITALPARgldhIAENILSYLDAKSLCAAELVCKEWYRVTS 121
Cdd:cd22131    1 DFLKLLPLE----LSFYLLSFLDPESLLTCCLVSKQWNKVIS 38

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30
                 ....*....|....*....|....*....|..
gi 755562716  91 DHIAENILSYLDAKSLCAAELVCKEWYRVTSD 122
Cdd:cd22157    5 DDLVEEILSRLPAKSLLRFRCVCKQWNSLISS 36

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 755562716   91 DHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKK 128
Cdd:pfam00646   6 DDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43

F-box domain found in F-box only protein 9 (FBXO9) and similar proteins; FBXO9, also called FBX9, cross-immune reaction antigen 1, renal carcinoma antigen NY-REN-57, or VCIA1, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. FBXO9 acts as an E3 ubiquitin ligase that regulates the stability and activity of peroxisome proliferator-activated receptor gamma (PPARgamma) through ubiquitination. It is also required for adipocyte differentiation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 755562716  81 FITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIER 132
Cdd:cd22089    2 HISALPSEILLYILRWVVSDLDLRSLEQLSLVCRKFYLLARDPSIWRLACER 53

F-box domain found in F-box only protein 45 (FBXO45) and similar proteins; FBXO45, also called FBX45, or F-box/SPRY domain-containing protein 1, functions as the substrate-recognition component of E3 ubiquitin ligase complexes. It is critical for synaptogenesis, neuronal migration, and synaptic transmission. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 755562716  83 TALPARGLdhiaENILSYLDAKSLCAAELVCKEWYRVTS 121
Cdd:cd22111    2 ARLPSRVL----EVIFSYLDLPDLRNCSLVCKSWYRLLN 36

F-box domain found in F-box only protein 16 (FBXO16) and similar proteins; FBXO16, also called FBX16, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It functions as a tumor suppressor by attenuating nuclear beta-catenin function. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 755562716  97 ILSYLDAKSLCAAELVCkeWYrvtsdgmlWKKLIErmvrTDSLWRGLAERRGW 149
Cdd:cd22172   17 IFSFLDPRSLCRCAQVC--WY--------WKYLTE----LDQLWMPKCLRFGW 55

F-box domain found in F-box/WD repeat-containing protein 12 (FBXW12) and similar proteins; FBXW12, also called F-box and WD-40 domain-containing protein 12, or F-box only protein 35 (FBXO35), is the substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It functions as an epithelial growth suppressor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30
                 ....*....|....*....|....*....|...
gi 755562716  97 ILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKL 129
Cdd:cd22137   11 IFSFLDAFSLLQAAQVNKQWNKVADSDYLWRNL 43

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.

                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 755562716   448 CLRTLVEHSGRVFRLQF--DEFQIVSSSHDDTILIWD 482
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFspDGKYLASGSDDGTIKLWD 40

F-box domain found in F-box only protein 42 (FBXO42) and similar proteins; FBXO42, also called FBX42, or just one F-box and Kelch domain-containing protein (JFK), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It specifically recognizes p53/TP53, promoting its ubiquitination and degradation. FBXO42 is also involved in the ubiquitin-proteasome system that may play a role in the pathogenesis of Parkinson's disease (PD). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30
                 ....*....|....*....|....*....|...
gi 755562716  91 DHIAENILSYLD-AKSLCAAELVCKEWYRVTSD 122
Cdd:cd22110    6 EEILEYILSYLSpYGDLKSAALVCKRWHRIIKG 38