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Conserved domains on  [gi|755563274|ref|XP_011245550|]
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cyclin-J isoform X3 [Mus musculus]

Protein Classification

cyclin-J family protein( domain architecture ID 15334186)

cyclin-J family protein is involved in cell cycle regulation

Gene Ontology:  GO:0000079|GO:0016538
PubMed:  23861057|30185601

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 34-140 2.17e-43

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 145.82  E-value: 2.17e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563274  34 SPQLNLRRYFADLIAIVSNRFTLCPPARHLAVYLLDLFMDRYDISIQQLHLVALSCLLLASKFEEKEDSVPKLEQLNSLG 113
Cdd:cd20528    1 SPQLHLRRYLVDWLAVVSERLKLSDTTLHLAVYLLDRFMDRYDISEDQLHLVALTCLLLAAKFEELDDNIPKISDLNRYL 80

                         90       100
                 ....*....|....*....|....*..
gi 755563274 114 CMtnmnLVLTKQTLLHMELLLLETFQW 140
Cdd:cd20528   81 CN----SVYSKQEYLQMELLILEFFQW 103
CYCLIN_CCNJ-like_rpt2 cd20529
second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 145-233 8.87e-35

second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410232 [Multi-domain]  Cd Length: 101  Bit Score: 123.24  E-value: 8.87e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563274 145 PTAAHFIEYYLSEAVHETDLHDGWPMVCLEKTKLYMAKYADYFLEVSLQ------------AAACVASSRIILRLSPTWP 212
Cdd:cd20529    1 PTPAHFLEYYLSQGVLFVDDHDGLPSELLEKVKEYVRKYADFFLDLSLQdyaflnykpsllAAACIAAARKALGLSPTWP 80

                         90       100
                 ....*....|....*....|.
gi 755563274 213 TRLHRLTAYSWDFLVQCIERL 233
Cdd:cd20529   81 EELEKLTGYSEDELEPCVELL 101
 
Name Accession Description Interval E-value
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 34-140 2.17e-43

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 145.82  E-value: 2.17e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563274  34 SPQLNLRRYFADLIAIVSNRFTLCPPARHLAVYLLDLFMDRYDISIQQLHLVALSCLLLASKFEEKEDSVPKLEQLNSLG 113
Cdd:cd20528    1 SPQLHLRRYLVDWLAVVSERLKLSDTTLHLAVYLLDRFMDRYDISEDQLHLVALTCLLLAAKFEELDDNIPKISDLNRYL 80

                         90       100
                 ....*....|....*....|....*..
gi 755563274 114 CMtnmnLVLTKQTLLHMELLLLETFQW 140
Cdd:cd20528   81 CN----SVYSKQEYLQMELLILEFFQW 103
CYCLIN_CCNJ-like_rpt2 cd20529
second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 145-233 8.87e-35

second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410232 [Multi-domain]  Cd Length: 101  Bit Score: 123.24  E-value: 8.87e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563274 145 PTAAHFIEYYLSEAVHETDLHDGWPMVCLEKTKLYMAKYADYFLEVSLQ------------AAACVASSRIILRLSPTWP 212
Cdd:cd20529    1 PTPAHFLEYYLSQGVLFVDDHDGLPSELLEKVKEYVRKYADFFLDLSLQdyaflnykpsllAAACIAAARKALGLSPTWP 80

                         90       100
                 ....*....|....*....|.
gi 755563274 213 TRLHRLTAYSWDFLVQCIERL 233
Cdd:cd20529   81 EELEKLTGYSEDELEPCVELL 101
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 15-109 1.48e-16

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 75.25  E-value: 1.48e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563274   15 DIHQALRYKELKL---PSYKGQSPQLNL--RRYFADLIAIVSNRFTLCPPARHLAVYLLDLFMDRYDISIQQLHLVALSC 89
Cdd:pfam00134   1 DIFQYLRELELKYlpkPDYMDQQPDINPkmRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTC 80

                          90       100
                  ....*....|....*....|
gi 755563274   90 LLLASKFEekEDSVPKLEQL 109
Cdd:pfam00134  81 LFIAAKYE--EIYPPTVEDL 98
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 45-108 1.65e-09

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 54.14  E-value: 1.65e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755563274    45 DLIAIVSNRFTLCPPARHLAVYLLDLFMDRYDISIQQLHLVALSCLLLASKFEEKEDSVPKLEQ 108
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVH 64
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 145-283 1.24e-08

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 52.63  E-value: 1.24e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563274  145 PTAAHFIEYYLSEAVHETDLHdgwpmvclektKLYMAKYadyFLEVSLQ------------AAACVASSRIILRlSPTWP 212
Cdd:pfam02984   1 PTPLSFLRRFSKAADYLHDLE-----------LRTLAKY---LLELTLLdydflkyppsliAAAAVYLARKTLN-SPEWT 65

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755563274  213 TRLHRLTAYSWDFLVQCIERLLLAHdndvkeankqrgQSAPQSTQLTVFQtaqpsrpvHFQQPQYLHQSSL 283
Cdd:pfam02984  66 ETLEHYTGYSEEDLKPCVKLLLELL------------LNAPSSKLQAVRR--------KYSSSKFMKVSTL 116
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
10-234 4.41e-07

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 51.31  E-value: 4.41e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563274  10 GQLAADIHQALRYKELK-LPSYKGQSPQ----LNLRRYFADLIAIVSNRFTLCPPARHLAVYLLDLFMDRYDISIQQLHL 84
Cdd:COG5024  178 PEYASDIFEYLLKLELIdLPNPNYLIKQslyeWSMRSILVDWLVEVHGKFGLLPETLFLAINIIDRFLSSRVVSLEKYQL 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563274  85 VALSCLLLASKFEEKEDsvPKLEQLNSlgcMTNMNlvLTKQTLLHMELLLLETFQWNLCLPTAAHFIEyYLSEAvhetdl 164
Cdd:COG5024  258 VGISALFIASKYEEVNC--PSIKDLVY---ATDGA--FTRDDIIRAERYMLEVLDFNISWPSPMSFLR-RISKA------ 323

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563274 165 hDGWPMVclektklyMAKYADYFLEVSL------------QAAACVASSRIILRlSPTWPTRL-HRLTAYSWDFLVQCIE 231
Cdd:COG5024  324 -SDYDIF--------SRTPAKFSSEISPvdykfiqispswCAAAAMYLSRKILS-QNQWDRTLiHYSGNYTNPDLKPLNE 393


                 ...
gi 755563274 232 RLL 234
Cdd:COG5024  394 SNK 396
 
Name Accession Description Interval E-value
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 34-140 2.17e-43

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 145.82  E-value: 2.17e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563274  34 SPQLNLRRYFADLIAIVSNRFTLCPPARHLAVYLLDLFMDRYDISIQQLHLVALSCLLLASKFEEKEDSVPKLEQLNSLG 113
Cdd:cd20528    1 SPQLHLRRYLVDWLAVVSERLKLSDTTLHLAVYLLDRFMDRYDISEDQLHLVALTCLLLAAKFEELDDNIPKISDLNRYL 80

                         90       100
                 ....*....|....*....|....*..
gi 755563274 114 CMtnmnLVLTKQTLLHMELLLLETFQW 140
Cdd:cd20528   81 CN----SVYSKQEYLQMELLILEFFQW 103
CYCLIN_CCNJ-like_rpt2 cd20529
second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 145-233 8.87e-35

second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410232 [Multi-domain]  Cd Length: 101  Bit Score: 123.24  E-value: 8.87e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563274 145 PTAAHFIEYYLSEAVHETDLHDGWPMVCLEKTKLYMAKYADYFLEVSLQ------------AAACVASSRIILRLSPTWP 212
Cdd:cd20529    1 PTPAHFLEYYLSQGVLFVDDHDGLPSELLEKVKEYVRKYADFFLDLSLQdyaflnykpsllAAACIAAARKALGLSPTWP 80

                         90       100
                 ....*....|....*....|.
gi 755563274 213 TRLHRLTAYSWDFLVQCIERL 233
Cdd:cd20529   81 EELEKLTGYSEDELEPCVELL 101
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 15-109 1.48e-16

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 75.25  E-value: 1.48e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563274   15 DIHQALRYKELKL---PSYKGQSPQLNL--RRYFADLIAIVSNRFTLCPPARHLAVYLLDLFMDRYDISIQQLHLVALSC 89
Cdd:pfam00134   1 DIFQYLRELELKYlpkPDYMDQQPDINPkmRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTC 80

                          90       100
                  ....*....|....*....|
gi 755563274   90 LLLASKFEekEDSVPKLEQL 109
Cdd:pfam00134  81 LFIAAKYE--EIYPPTVEDL 98
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 13-98 5.44e-13

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 65.24  E-value: 5.44e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563274  13 AADIHQALRYKELKL---PSYKGQSPQLN--LRRYFADLIAIVSNRFTLCPPARHLAVYLLDLFMDRYDISIQQLHLVAL 87
Cdd:cd20507    5 VKDIYKYLRQLEKKYaidPDYLSGQPEITerMRAILVDWLVEVHLKFKLLPETLYLTVNIIDRYLSKKQVPRKKLQLVGV 84

                         90
                 ....*....|.
gi 755563274  88 SCLLLASKFEE 98
Cdd:cd20507   85 TALLIASKYEE 95
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 13-108 3.06e-11

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410265  Cd Length: 136  Bit Score: 60.50  E-value: 3.06e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563274  13 AADIHQALRYKELK---LPSY--KGQSP-QLNLRRYFADLIAIVSNRFTLCPPARHLAVYLLDLFMDRYDISIQQLHLVA 86
Cdd:cd20562    9 ATDIYLNLRVAELKrrpLPDYmeKIQRDiTPSMRGILVDWLVEVAEEYKLVPDTLYLTVSYIDRFLSGNYVNRQRLQLLG 88

                         90       100
                 ....*....|....*....|..
gi 755563274  87 LSCLLLASKFEEKedSVPKLEQ 108
Cdd:cd20562   89 VSCMLIASKYEEI--CAPQVEE 108
CYCLIN_CLBs_yeast_rpt1 cd20568
first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces ...
 11-98 1.59e-10

first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410271  Cd Length: 134  Bit Score: 58.46  E-value: 1.59e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563274  11 QLAADIHQALRYKELKL---PSYKGQSPQL--NLRRYFADLIAIVSNRFTLCPPARHLAVYLLDLFMDRYDISIQQLHLV 85
Cdd:cd20568    7 EYVPEIFEYLRELELKTlpnPNYMDDQKELrwKMRGILVDWLVEVHEKFRLLPETLFLAVNIIDRFLSKRVVSLNKLQLV 86

                         90
                 ....*....|...
gi 755563274  86 ALSCLLLASKFEE 98
Cdd:cd20568   87 GISALFIASKYEE 99
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 45-108 1.65e-09

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 54.14  E-value: 1.65e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755563274    45 DLIAIVSNRFTLCPPARHLAVYLLDLFMDRYDISIQQLHLVALSCLLLASKFEEKEDSVPKLEQ 108
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVH 64
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 145-283 1.24e-08

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 52.63  E-value: 1.24e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563274  145 PTAAHFIEYYLSEAVHETDLHdgwpmvclektKLYMAKYadyFLEVSLQ------------AAACVASSRIILRlSPTWP 212
Cdd:pfam02984   1 PTPLSFLRRFSKAADYLHDLE-----------LRTLAKY---LLELTLLdydflkyppsliAAAAVYLARKTLN-SPEWT 65

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755563274  213 TRLHRLTAYSWDFLVQCIERLLLAHdndvkeankqrgQSAPQSTQLTVFQtaqpsrpvHFQQPQYLHQSSL 283
Cdd:pfam02984  66 ETLEHYTGYSEEDLKPCVKLLLELL------------LNAPSSKLQAVRR--------KYSSSKFMKVSTL 116
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 45-109 1.42e-08

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 51.26  E-value: 1.42e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755563274  45 DLIAIVSNRFTLCPPARHLAVYLLDLFMDRYDISIQQLHLVALSCLLLASKFEEKEDSVPKLEQL 109
Cdd:cd00043    4 DFIRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKLEELPRTLKEIAKV 68
CYCLIN_CCNA_rpt1 cd20504
first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 11-98 1.22e-07

first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. The model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410208 [Multi-domain]  Cd Length: 128  Bit Score: 49.94  E-value: 1.22e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563274  11 QLAADIHQALRYKELKL---PSYKGQSPQLN--LRRYFADLIAIVSNRFTLCPPARHLAVYLLDLFMDRYDISIQQLHLV 85
Cdd:cd20504    1 EYADDIYEYLRESELKHrpkPDYMRKQPDINpsMRSILVDWLVEVAEEYKLVPETLYLAVNYIDRFLSQMSVLRSKLQLV 80

                         90
                 ....*....|...
gi 755563274  86 ALSCLLLASKFEE 98
Cdd:cd20504   81 GTACMFIAAKYEE 93
CYCLIN_CCNO-like_rpt2 cd20537
second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of ...
 145-239 1.54e-07

second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of CCNO and similar proteins including Schizosaccharomyces pombe meiosis-specific cyclin rem1, Drosophila melanogaster G2/mitotic-specific cyclin-A (CCNA), and Candida albicans G1/S-specific cyclin CCN1, among others. Rem1 is required for pre-meiotic DNA synthesis and S phase progression. CCNA is essential for the control of the cell cycle at the G2/M (mitosis) transition. CCN1 is essential for the control of the cell cycle at the G1/S (start) transition and for maintenance of filamentous growth. CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It is involved in the activation of cyclin-dependent kinase 2. Members of this subfamily contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410240 [Multi-domain]  Cd Length: 91  Bit Score: 48.84  E-value: 1.54e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563274 145 PTAAHFIEYYLSEAVHETDLHdgwpmvclektklYMAKYadyFLEVSLQ------------AAACVASSRIILRLSPTWP 212
Cdd:cd20537    1 PTPLSFLRRYLSLLGLDEKVR-------------HLARY---LLELSLLdyeflkyrpsliAAAALYLARKILGEPPPSP 64

                         90       100
                 ....*....|....*....|....*..
gi 755563274 213 TRLHRLTAYSWDFLVQCIERLLLAHDN 239
Cdd:cd20537   65 QLLQLVTGYSENDLQECAKELLELLAQ 91
CYCLIN_ScCLN_like cd20559
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar ...
 45-117 1.56e-07

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410262 [Multi-domain]  Cd Length: 95  Bit Score: 48.92  E-value: 1.56e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755563274  45 DLIAIVSNRFTLCPPARHLAVYLLDLFMDRYDISIQQLHLVALSCLLLASKFEEKEDSVPKLEQLNSLGCMTN 117
Cdd:cd20559    4 DFLFELHVELRLSPQTFFLSVNLIDRYCSKRIVLKKHYQLVGCTCLWIASKFWESKARVPLLSELSKMCCNSY 76
CYCLIN_CCNA2_rpt1 cd20561
first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S ...
 13-98 1.82e-07

first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly over-expressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410264 [Multi-domain]  Cd Length: 131  Bit Score: 49.67  E-value: 1.82e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563274  13 AADIHQALRYKELKL---PSYKGQSPQL--NLRRYFADLIAIVSNRFTLCPPARHLAVYLLDLFMDRYDISIQQLHLVAL 87
Cdd:cd20561    5 HEDIHTYLREMEVKCkpkVGYMKKQPDItnSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGT 84

                         90
                 ....*....|.
gi 755563274  88 SCLLLASKFEE 98
Cdd:cd20561   85 AAMLLASKFEE 95
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
10-234 4.41e-07

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 51.31  E-value: 4.41e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563274  10 GQLAADIHQALRYKELK-LPSYKGQSPQ----LNLRRYFADLIAIVSNRFTLCPPARHLAVYLLDLFMDRYDISIQQLHL 84
Cdd:COG5024  178 PEYASDIFEYLLKLELIdLPNPNYLIKQslyeWSMRSILVDWLVEVHGKFGLLPETLFLAINIIDRFLSSRVVSLEKYQL 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563274  85 VALSCLLLASKFEEKEDsvPKLEQLNSlgcMTNMNlvLTKQTLLHMELLLLETFQWNLCLPTAAHFIEyYLSEAvhetdl 164
Cdd:COG5024  258 VGISALFIASKYEEVNC--PSIKDLVY---ATDGA--FTRDDIIRAERYMLEVLDFNISWPSPMSFLR-RISKA------ 323

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563274 165 hDGWPMVclektklyMAKYADYFLEVSL------------QAAACVASSRIILRlSPTWPTRL-HRLTAYSWDFLVQCIE 231
Cdd:COG5024  324 -SDYDIF--------SRTPAKFSSEISPvdykfiqispswCAAAAMYLSRKILS-QNQWDRTLiHYSGNYTNPDLKPLNE 393


                 ...
gi 755563274 232 RLL 234
Cdd:COG5024  394 SNK 396
CYCLIN_CCNA1_rpt1 cd20560
first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of ...
 10-98 7.48e-07

first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410263  Cd Length: 163  Bit Score: 48.68  E-value: 7.48e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563274  10 GQLAADIHQALRYKELKL---PSYKGQSPQLN--LRRYFADLIAIVSNRFTLCPPARHLAVYLLDLFMDRYDISIQQLHL 84
Cdd:cd20560   34 PEYAEDIHQYLREAELKHrpkPGYMRKQPDITtgMRTILVDWLVEVGEEYKLQTETLYLAVNYLDRFLSCMSVLRGKLQL 113

                         90
                 ....*....|....
gi 755563274  85 VALSCLLLASKFEE 98
Cdd:cd20560  114 VGTAAILLASKYEE 127
CYCLIN_CNTD2 cd20542
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; ...
 62-98 9.96e-07

cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410245 [Multi-domain]  Cd Length: 96  Bit Score: 46.55  E-value: 9.96e-07
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 755563274  62 HLAVYLLDLFMDRYDISIQQLHLVALSCLLLASKFEE 98
Cdd:cd20542   23 HLAVALLDRYLSRQKISLSLLQLLGITCLFIACKFEE 59
CYCLIN_AtCycB-like_rpt1 cd20567
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 11-109 5.81e-06

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410270  Cd Length: 147  Bit Score: 45.80  E-value: 5.81e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563274  11 QLAA-----DIHQALRYKELKL---PSYKGQSPQLN--LRRYFADLIAIVSNRFTLCPPARHLAVYLLDLFMDRYDISIQ 80
Cdd:cd20567   15 PLAAveyveDIYSFYRKVEPEScvpPYYMSQQPDINekMRAILIDWLIEVHLKFELMPETLYLTVNLIDRFLSVKQVPRK 94

                         90       100
                 ....*....|....*....|....*....
gi 755563274  81 QLHLVALSCLLLASKFEEKedSVPKLEQL 109
Cdd:cd20567   95 ELQLVGVTAMLIASKYEEI--WAPEVNDF 121
CYCLIN_CCNB2_rpt1 cd20566
first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is ...
 15-98 7.84e-06

first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410269 [Multi-domain]  Cd Length: 133  Bit Score: 44.85  E-value: 7.84e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563274  15 DIHQALRYKELKL---PSY-KGQSPQLNLRRYFADLIAIVSNRFTLCPPARHLAVYLLDLFMDRYDISIQQLHLVALSCL 90
Cdd:cd20566   11 DIYQYLRQLEVQQsirPHYlDGKEINERMRAILVDWLVQVHSRFQLLQETLYMCVAIMDRFLQVQPVSRKKLQLVGVTAL 90


                 ....*...
gi 755563274  91 LLASKFEE 98
Cdd:cd20566   91 LLASKYEE 98
CYCLIN_CCNB1_rpt1 cd20565
first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the ...
 15-98 1.16e-05

first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410268 [Multi-domain]  Cd Length: 129  Bit Score: 44.48  E-value: 1.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563274  15 DIHQALRYKELKL---PSY-KGQSPQLNLRRYFADLIAIVSNRFTLCPPARHLAVYLLDLFMDRYDISIQQLHLVALSCL 90
Cdd:cd20565    7 DIYAYLRQLEEEQavrPKYlEGQEVTGNMRAILIDWLVQVQMKFRLLQETMYMTVAIIDRFLQNNPVPKKMLQLVGVTAM 86


                 ....*...
gi 755563274  91 LLASKFEE 98
Cdd:cd20565   87 FIASKYEE 94
CYCLIN_CCNB3_rpt1 cd20508
first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is ...
 11-99 4.38e-05

first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410212 [Multi-domain]  Cd Length: 142  Bit Score: 43.01  E-value: 4.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755563274  11 QLAADIHQALRYKELK--LPSYKGQSPQLN--LRRYFADLIAIVSNRFTLCPPARHLAVYLLDLFMDRYDISIQQLHLVA 86
Cdd:cd20508   15 EYAKDIFDYMKEREEKfvVPDYLEKQTELTpsMRAILVDWLVEVQENFELNHETLYLAVKLVDLYLSKKVVKKEKLQLLG 94

                         90
                 ....*....|...
gi 755563274  87 LSCLLLASKFEEK 99
Cdd:cd20508   95 ATAILIASKFDER 107
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 45-113 4.74e-05

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410246  Cd Length: 99  Bit Score: 41.92  E-value: 4.74e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755563274  45 DLIAIVSNRFTLCPPARHLAVYLLDLFMDRYDISIQQ---LHLVALSCLLLASKFEekEDSVPKLEQLNSLG 113
Cdd:cd20543    7 DWILKVRSRYGFGPLTAYLAVNYLDRFLSSYDLPKDKpwmLQLLAVACLSLAAKME--ETDVPLLVDLQVEE 76
CYCLIN_CCNO_rpt1 cd20536
first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required ...
 50-114 1.93e-03

first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410239  Cd Length: 93  Bit Score: 37.31  E-value: 1.93e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755563274  50 VSNRFTLCPPARHLAVYLLDLFMDRYDISIQQLHLVALSCLLLASKFEEKEDsvPKLEQLNSLGC 114
Cdd:cd20536   12 VHRHFNLSQETLFLAVNILDRFLATTPVARDCFQLLGVTSLLIACKQEEIYP--PEVKDLLALCC 74
CYCLIN_CCNE_rpt1 cd20519
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 62-98 2.29e-03

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410223  Cd Length: 131  Bit Score: 37.68  E-value: 2.29e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 755563274  62 HLAVYLLDLFMDR-YDISIQQLHLVALSCLLLASKFEE 98
Cdd:cd20519   59 YLAVDFVDRYLSTqTNVPKTQLQLIGITCLFIAAKLEE 96
CYCLIN_CCNI-like cd20526
cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because ...
 47-109 2.44e-03

cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because it is most abundant in post-mitotic cells. It is involved in various biological processes, such as cell survival, angiogenesis, cell differentiation, and cell cycle progression. CCNI contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. The cyclin box is a protein binding domain.


Pssm-ID: 410230  Cd Length: 99  Bit Score: 36.91  E-value: 2.44e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755563274  47 IAIVSNRFTLCPPARHLAVYLLDLFMDRYDISIQQLHLVALSCLLLASKFEEKEDSVPKLEQL 109
Cdd:cd20526    9 LAELNSQFKFYPETFALAVSILDRFLASVKARPKYLRCIAISCLFLAAKTNEEDEVIPSTKDL 71
CYCLIN_CCNF_rpt1 cd20521
first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also ...
 62-100 3.80e-03

first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410225  Cd Length: 95  Bit Score: 36.53  E-value: 3.80e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 755563274  62 HLAVYLLDLFMDRYDISIQQLHLVALSCLLLASKFEEKE 100
Cdd:cd20521   26 HVAVSCVDRYLMVRKVPRSKLQLLGIACMVIATRFLGKD 64
CYCLIN_CCNG1 cd20583
cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has ...
 54-104 3.80e-03

cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG1 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410286  Cd Length: 98  Bit Score: 36.34  E-value: 3.80e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 755563274  54 FTLCPPARHLAVYLLDLFMDRYDISIQQLHLVALSCLLLASKFEEKEDSVP 104
Cdd:cd20583   16 FGFSTETFSLAVNLLDRFLAKMKVQPKHLGCVGLSCFYLAVKAIEEERNVP 66
CYCLIN_CCNG cd20523
cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 ...
 54-109 7.46e-03

cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 and CCNG2. CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410227  Cd Length: 94  Bit Score: 35.41  E-value: 7.46e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 755563274  54 FTLCPPARHLAVYLLDLFMDRYDISIQQLHLVALSCLLLASKFEEKEDSVPKLEQL 109
Cdd:cd20523   15 YGFSPETFALAVNLLDRFLSKVKVKPKHLACITVSCFHIAIKSVEEDQNIPSAEDL 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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