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Conserved domains on  [gi|755566158|ref|XP_011246036|]
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tRNA (uracil-5-)-methyltransferase homolog B isoform X2 [Mus musculus]

Protein Classification

class I SAM-dependent RNA methyltransferase( domain architecture ID 1903519)

class I SAM-dependent RNA methyltransferase catalyzes the methylation of a specific RNA substrate using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0008173|GO:1904047
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TrmA super family cl43665
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 83-421 3.13e-48

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


The actual alignment was detected with superfamily member COG2265:

Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 169.20  E-value: 3.13e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566158  83 LSYEAQLKVKfeaQKKLLQSLESHlkvlhGVSDTVAahqseglrclLHPIIPSPTTTGYRNKSTFSVYRSpDGNPkTVGY 162
Cdd:COG2265   81 LSYEAQLELK---QRVVREALERI-----GGLPEVE----------VEPIIGSPEPWGYRNRARLSVRRT-DGRL-RLGF 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566158 163 YlgtwkdgnvvclpcnhlknipEKHSqvaqyYEVFlrqsSVEPCLLFHEgghwrelvvrtnrqgHTMAIVTfhpqglsee 242
Cdd:COG2265  141 Y---------------------ARGS-----HELV----DIDECPLLDP---------------ALNALLP--------- 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566158 243 evcvqkvTLKDFFTKGPGAICELTSLyfqestMTRCshqqspyqllfGEPHIFEDLLGLKIRISPDAFFQINTAGAEMLY 322
Cdd:COG2265  167 -------ALRELLAELGARRGELRHL------VVRA-----------GRDYLTERLGGLTFRISPGSFFQVNPEQAEALY 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566158 323 RIIGELSGVNSESLLLDICCGTGVIGLSVAQRASQVHGIELVEQAVEDARWTAAFNGVTNCEFHAGRAETILPQLLksqK 402
Cdd:COG2265  223 AAALEWLDLTGGERVLDLYCGVGTFALPLARRAKKVIGVEIVPEAVEDARENARLNGLKNVEFVAGDLEEVLPELL---W 299

                        330
                 ....*....|....*....
gi 755566158 403 DEKLTVAVVNPARAGLRKD 421
Cdd:COG2265  300 GGRPDVVVLDPPRAGAGPE 318
 
Name Accession Description Interval E-value
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 83-421 3.13e-48

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 169.20  E-value: 3.13e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566158  83 LSYEAQLKVKfeaQKKLLQSLESHlkvlhGVSDTVAahqseglrclLHPIIPSPTTTGYRNKSTFSVYRSpDGNPkTVGY 162
Cdd:COG2265   81 LSYEAQLELK---QRVVREALERI-----GGLPEVE----------VEPIIGSPEPWGYRNRARLSVRRT-DGRL-RLGF 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566158 163 YlgtwkdgnvvclpcnhlknipEKHSqvaqyYEVFlrqsSVEPCLLFHEgghwrelvvrtnrqgHTMAIVTfhpqglsee 242
Cdd:COG2265  141 Y---------------------ARGS-----HELV----DIDECPLLDP---------------ALNALLP--------- 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566158 243 evcvqkvTLKDFFTKGPGAICELTSLyfqestMTRCshqqspyqllfGEPHIFEDLLGLKIRISPDAFFQINTAGAEMLY 322
Cdd:COG2265  167 -------ALRELLAELGARRGELRHL------VVRA-----------GRDYLTERLGGLTFRISPGSFFQVNPEQAEALY 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566158 323 RIIGELSGVNSESLLLDICCGTGVIGLSVAQRASQVHGIELVEQAVEDARWTAAFNGVTNCEFHAGRAETILPQLLksqK 402
Cdd:COG2265  223 AAALEWLDLTGGERVLDLYCGVGTFALPLARRAKKVIGVEIVPEAVEDARENARLNGLKNVEFVAGDLEEVLPELL---W 299

                        330
                 ....*....|....*....
gi 755566158 403 DEKLTVAVVNPARAGLRKD 421
Cdd:COG2265  300 GGRPDVVVLDPPRAGAGPE 318
rumB PRK03522
23S rRNA (uracil(747)-C(5))-methyltransferase RlmC;
290-421 9.18e-14

23S rRNA (uracil(747)-C(5))-methyltransferase RlmC;


Pssm-ID: 235128 [Multi-domain]  Cd Length: 315  Bit Score: 71.82  E-value: 9.18e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566158 290 GEPHIF--------EDLLGLKIRISPDAFFQINTAGAEMLYRI----IGELsGVNSeslLLDICCGTGVIGLSVAQRASQ 357
Cdd:PRK03522 122 GEEEIFlteqqalpERFNGVPLFIRPQSFFQTNPAVAAQLYATardwVREL-PPRS---MWDLFCGVGGFGLHCATPGMQ 197

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755566158 358 VHGIELVEQAVEDARWTAAFNGVTNCEFHAGRAETILpqllkSQKDEKLTVAVVNPARAGLRKD 421
Cdd:PRK03522 198 LTGIEISAEAIACAKQSAAELGLTNVQFQALDSTQFA-----TAQGEVPDLVLVNPPRRGIGKE 256
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 337-402 2.61e-08

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 52.80  E-value: 2.61e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755566158  337 LLDICCGTGVIGLSVAQRA---SQVHGIELVEQAVEDARWTAAFNGVTNCEFHAGRAETiLPQLLKSQK 402
Cdd:pfam13847   7 VLDLGCGTGHLSFELAEELgpnAEVVGIDISEEAIEKARENAQKLGFDNVEFEQGDIEE-LPELLEDDK 74
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 337-414 2.50e-06

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 45.88  E-value: 2.50e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755566158 337 LLDICCGTGVIGLSVAQR-ASQVHGIELVEQAVEDARWTAAFNGVTNCEFHAGRAETILPqllksQKDEKLTVAVVNPA 414
Cdd:cd02440    2 VLDLGCGTGALALALASGpGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPP-----EADESFDVIISDPP 75
 
Name Accession Description Interval E-value
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 83-421 3.13e-48

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 169.20  E-value: 3.13e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566158  83 LSYEAQLKVKfeaQKKLLQSLESHlkvlhGVSDTVAahqseglrclLHPIIPSPTTTGYRNKSTFSVYRSpDGNPkTVGY 162
Cdd:COG2265   81 LSYEAQLELK---QRVVREALERI-----GGLPEVE----------VEPIIGSPEPWGYRNRARLSVRRT-DGRL-RLGF 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566158 163 YlgtwkdgnvvclpcnhlknipEKHSqvaqyYEVFlrqsSVEPCLLFHEgghwrelvvrtnrqgHTMAIVTfhpqglsee 242
Cdd:COG2265  141 Y---------------------ARGS-----HELV----DIDECPLLDP---------------ALNALLP--------- 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566158 243 evcvqkvTLKDFFTKGPGAICELTSLyfqestMTRCshqqspyqllfGEPHIFEDLLGLKIRISPDAFFQINTAGAEMLY 322
Cdd:COG2265  167 -------ALRELLAELGARRGELRHL------VVRA-----------GRDYLTERLGGLTFRISPGSFFQVNPEQAEALY 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566158 323 RIIGELSGVNSESLLLDICCGTGVIGLSVAQRASQVHGIELVEQAVEDARWTAAFNGVTNCEFHAGRAETILPQLLksqK 402
Cdd:COG2265  223 AAALEWLDLTGGERVLDLYCGVGTFALPLARRAKKVIGVEIVPEAVEDARENARLNGLKNVEFVAGDLEEVLPELL---W 299

                        330
                 ....*....|....*....
gi 755566158 403 DEKLTVAVVNPARAGLRKD 421
Cdd:COG2265  300 GGRPDVVVLDPPRAGAGPE 318
rumB PRK03522
23S rRNA (uracil(747)-C(5))-methyltransferase RlmC;
290-421 9.18e-14

23S rRNA (uracil(747)-C(5))-methyltransferase RlmC;


Pssm-ID: 235128 [Multi-domain]  Cd Length: 315  Bit Score: 71.82  E-value: 9.18e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566158 290 GEPHIF--------EDLLGLKIRISPDAFFQINTAGAEMLYRI----IGELsGVNSeslLLDICCGTGVIGLSVAQRASQ 357
Cdd:PRK03522 122 GEEEIFlteqqalpERFNGVPLFIRPQSFFQTNPAVAAQLYATardwVREL-PPRS---MWDLFCGVGGFGLHCATPGMQ 197

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755566158 358 VHGIELVEQAVEDARWTAAFNGVTNCEFHAGRAETILpqllkSQKDEKLTVAVVNPARAGLRKD 421
Cdd:PRK03522 198 LTGIEISAEAIACAKQSAAELGLTNVQFQALDSTQFA-----TAQGEVPDLVLVNPPRRGIGKE 256
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 337-421 2.21e-11

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 62.51  E-value: 2.21e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566158 337 LLDICCGTGVIGLSVAQRA--SQVHGIELVEQAVEDARWTAAFNGVTNCEFHAgraetilPQLLKSQKDEKLTVAVVN-P 413
Cdd:COG2813   53 VLDLGCGYGVIGLALAKRNpeARVTLVDVNARAVELARANAAANGLENVEVLW-------SDGLSGVPDGSFDLILSNpP 125


                 ....*...
gi 755566158 414 ARAGLRKD 421
Cdd:COG2813  126 FHAGRAVD 133
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 337-413 1.09e-09

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 58.62  E-value: 1.09e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566158 337 LLDICCGTGVIGLSVAQR--ASQVHGIELVEQAVEDARWTAAFNGVTN-CEFHAGRaetiLPQLLKSQKDEKLTVAVVNP 413
Cdd:COG4123   41 VLDLGTGTGVIALMLAQRspGARITGVEIQPEAAELARRNVALNGLEDrITVIHGD----LKEFAAELPPGSFDLVVSNP 116
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 337-402 2.61e-08

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 52.80  E-value: 2.61e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755566158  337 LLDICCGTGVIGLSVAQRA---SQVHGIELVEQAVEDARWTAAFNGVTNCEFHAGRAETiLPQLLKSQK 402
Cdd:pfam13847   7 VLDLGCGTGHLSFELAEELgpnAEVVGIDISEEAIEKARENAQKLGFDNVEFEQGDIEE-LPELLEDDK 74
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 338-393 5.07e-08

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 50.64  E-value: 5.07e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 755566158  338 LDICCGTGVIGLSVAQRA-SQVHGIELVEQAVEDARWTAAFNGVtNCEFHAGRAETI 393
Cdd:pfam13649   2 LDLGCGTGRLTLALARRGgARVTGVDLSPEMLERARERAAEAGL-NVEFVQGDAEDL 57
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 338-413 1.45e-07

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 51.05  E-value: 1.45e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755566158  338 LDICCGTGVIGLSVAQRASQVHgIELVE---QAVEDARWTAAFNGVTNCEFHAGraetilpQLLKSQKDEKLTVAVVNP 413
Cdd:pfam05175  36 LDLGCGAGVLGAALAKESPDAE-LTMVDinaRALESARENLAANGLENGEVVAS-------DVYSGVEDGKFDLIISNP 106
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 338-413 6.54e-07

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 50.55  E-value: 6.54e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755566158 338 LDICCGTGVIGLSVAQR--ASQVHGIELVEQAVEDARWTAAFNGVTNCEFHAGRaetilpqLLKSQKDEKLTVAVVNP 413
Cdd:PRK09328 113 LDLGTGSGAIALALAKErpDAEVTAVDISPEALAVARRNAKHGLGARVEFLQGD-------WFEPLPGGRFDLIVSNP 183
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 337-393 1.18e-06

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 47.68  E-value: 1.18e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 755566158 337 LLDICCGTGVIGLSVAQRASQVHGIELVEQAVEDARWTAAFNGVtNCEFHAGRAETI 393
Cdd:COG2226   26 VLDLGCGTGRLALALAERGARVTGVDISPEMLELARERAAEAGL-NVEFVVGDAEDL 81
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 284-388 1.56e-06

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 49.38  E-value: 1.56e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566158 284 PYQLLFGEphifEDLLGLKIRISPDAFfqI---NTAgaEMLYRIIGELSGvNSESLLLDICCGTGVIGLSVAQR--ASQV 358
Cdd:COG2890   69 PLAYILGE----AEFYGLEFKVDPGVL--IprpETE--ELVELALALLPA-GAPPRVLDLGTGSGAIALALAKErpDARV 139

                         90       100       110
                 ....*....|....*....|....*....|.
gi 755566158 359 HGIELVEQAVEDARWTAAFNGVTN-CEFHAG 388
Cdd:COG2890  140 TAVDISPDALAVARRNAERLGLEDrVRFLQG 170
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 337-414 2.50e-06

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 45.88  E-value: 2.50e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755566158 337 LLDICCGTGVIGLSVAQR-ASQVHGIELVEQAVEDARWTAAFNGVTNCEFHAGRAETILPqllksQKDEKLTVAVVNPA 414
Cdd:cd02440    2 VLDLGCGTGALALALASGpGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPP-----EADESFDVIISDPP 75
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 338-395 7.99e-06

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 46.45  E-value: 7.99e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 755566158 338 LDICCGTGVIGLSVAQRA-SQVHGIELVEQAVEDARWTAAFNGVTNCEFHAGRAETILP 395
Cdd:COG0500   31 LDLGCGTGRNLLALAARFgGRVIGIDLSPEAIALARARAAKAGLGNVEFLVADLAELDP 89
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 337-393 1.19e-05

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 44.62  E-value: 1.19e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 755566158 337 LLDICCGTGVIGLSVAQRASQVHGIELVEQAVEDARWTAAFNGVtncEFHAGRAETI 393
Cdd:COG2227   28 VLDVGCGTGRLALALARRGADVTGVDISPEALEIARERAAELNV---DFVQGDLEDL 81
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
331-423 3.99e-05

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 44.64  E-value: 3.99e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566158 331 VNSESLLLDICCGTGVIG-LSVAQRASQVHGIELVEQAVEDARWTAAFNGVT-NCEFHAG---------RAETILPQLLK 399
Cdd:COG4076   33 VKPGDVVLDIGTGSGLLSmLAARAGAKKVYAVEVNPDIAAVARRIIAANGLSdRITVINAdatdldlpeKADVIISEMLD 112

                         90       100
                 ....*....|....*....|....*
gi 755566158 400 SQK-DEKLtVAVVNPARAGLRKDGG 423
Cdd:COG4076  113 TALlDEGQ-VPILNHARKRLLKPGG 136
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
338-396 6.36e-05

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 41.73  E-value: 6.36e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755566158 338 LDICCGTGVIGLSVAQR--ASQVHGIELVEQAVEDARwtaafNGVTNCEFHAGRAETILPQ 396
Cdd:COG4106    6 LDLGCGTGRLTALLAERfpGARVTGVDLSPEMLARAR-----ARLPNVRFVVADLRDLDPP 61
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
338-372 1.51e-04

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 42.29  E-value: 1.51e-04
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 755566158 338 LDICCGTGVIGLSVAQRASQVHGIELVEQAVEDAR 372
Cdd:COG4976   51 LDLGCGTGLLGEALRPRGYRLTGVDLSEEMLAKAR 85
PRK14968 PRK14968
putative methyltransferase; Provisional
 338-413 3.03e-04

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 41.42  E-value: 3.03e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755566158 338 LDICCGTGVIGLSVAQRASQVHGIELVEQAVEDARWTAAFNGVTNCEFHAGRAEtilpqLLKSQKDEKLTVAVVNP 413
Cdd:PRK14968  28 LEVGTGSGIVAIVAAKNGKKVVGVDINPYAVECAKCNAKLNNIRNNGVEVIRSD-----LFEPFRGDKFDVILFNP 98
CobL COG2242
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ...
 335-397 6.83e-04

Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441843 [Multi-domain]  Cd Length: 403  Bit Score: 41.69  E-value: 6.83e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755566158 335 SLLLDICCGTGVIGLSVAQRA--SQVHGIELVEQAVEDARWTA-AFnGVTNCEFHAGRAETILPQL 397
Cdd:COG2242  249 DVLWDIGAGSGSVSIEAARLApgGRVYAIERDPERAALIRANArRF-GVPNVEVVEGEAPEALADL 313
tRNA_U5-meth_tr pfam05958
tRNA (Uracil-5-)-methyltransferase; This family consists of (Uracil-5-)-methyltransferases EC: ...
 308-421 2.24e-03

tRNA (Uracil-5-)-methyltransferase; This family consists of (Uracil-5-)-methyltransferases EC:2.1.1.35 from bacteria, archaea and eukaryotes. A 5-methyluridine (m(5)U) residue at position 54 is a conserved feature of bacterial and eukaryotic tRNAs. The methylation of U54 is catalyzed by the tRNA(m5U54)methyltransferase, which in Saccharomyces cerevisiae is encoded by the nonessential TRM2 gene. It is thought that tRNA modification enzymes might have a role in tRNA maturation not necessarily linked to their known catalytic activity.


Pssm-ID: 428692  Cd Length: 357  Bit Score: 40.11  E-value: 2.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566158  308 DAFFQINTAGAE-ML---YRIIGelsgvNSESLLLDICCGTGVIGLSVAQRASQVHGIELVEQAVEDARWTAAFNGVTNC 383
Cdd:pfam05958 177 NSFTQPNAAVNIkMLewaCDVTQ-----GSKGDLLELYCGNGNFSLALARNFRKVLATEIAKPSVAAAQYNIAANNIDNV 251

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 755566158  384 EFHAGRAETiLPQLLKSQ-----------KDEKLTVAVVNPARAGLRKD 421
Cdd:pfam05958 252 QIIRMSAEE-FTQAMNGVrefnrlkgidlKSYNCSTIFVDPPRAGLDPE 299
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 338-428 4.08e-03

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 39.17  E-value: 4.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566158  338 LDICCGTGVigLSVAQR---ASQVHGIELVEQAVEDARWTAAFNGVTNcefhagRAETILPQ-LLKSQKDekltVAVVN- 412
Cdd:pfam06325 166 LDVGCGSGI--LAIAALklgAKKVVGVDIDPVAVRAAKENAELNGVEA------RLEVYLPGdLPKEKAD----VVVANi 233

                          90       100
                  ....*....|....*....|....*
gi 755566158  413 ---------PARAGLRKDGGHLGCS 428
Cdd:pfam06325 234 ladplielaPDIYALVKPGGYLILS 258
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
318-372 4.12e-03

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 38.35  E-value: 4.12e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 755566158 318 AEMLY--RIIGELSGvnseSLLLDICCGTGVIGLSVAQR-ASQVHGIELVEQAVEDAR 372
Cdd:COG2263   32 AELLHlaYLRGDIEG----KTVLDLGCGTGMLAIGAALLgAKKVVGVDIDPEALEIAR 85
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
337-402 5.81e-03

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 38.62  E-value: 5.81e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755566158 337 LLDICCGTGVigLSVA---QRASQVHGIELVEQAVEDARWTAAFNGVtncefhAGRAETILPQLLKSQK 402
Cdd:COG2264  152 VLDVGCGSGI--LAIAaakLGAKRVLAVDIDPVAVEAARENAELNGV------EDRIEVVLGDLLEDGP 212
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 323-413 6.41e-03

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 37.62  E-value: 6.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566158 323 RIIGELSGVNSESLLLDICCGTGVIGLSVAQRASQVHGIELVEQAVEDARWTAAFNGVTNCEFHAGRAETIlpqllkSQK 402
Cdd:COG1041   16 RALVNLAGAKEGDTVLDPFCGTGTILIEAGLLGRRVIGSDIDPKMVEGARENLEHYGYEDADVIRGDARDL------PLA 89

                         90
                 ....*....|.
gi 755566158 403 DEKLTVAVVNP 413
Cdd:COG1041   90 DESVDAIVTDP 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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