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Conserved domains on  [gi|755493908|ref|XP_011246240|]
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peptidyl-glycine alpha-amidating monooxygenase isoform X4 [Mus musculus]

Protein Classification

peptidyl-glycine alpha-amidating monooxygenase( domain architecture ID 10471209)

peptidyl-glycine alpha-amidating monooxygenase is a bifunctional enzyme that catalyzes the post-translational modification of inactive peptidylglycine precursors to the corresponding bioactive alpha-amidated peptides, a terminal modification in biosynthesis of many neural and endocrine peptides

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NHL_PAL_like cd14958
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the ...
 503-810 8.87e-148

Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the N-dealkylation of peptidyl-alpha-hydroxyglycine, which results in an alpha-amidated peptide and glyoxylate. Amidation of the C-terminus is required for the activity of many peptide hormones and neuropeptides. The catalytic residues of PAL are located on several NHL-repeats. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


:

Pssm-ID: 271328 [Multi-domain]  Cd Length: 300  Bit Score: 438.62  E-value: 8.87e-148
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 503 EALEWPGVYLLPGQVSGVALDSKNNLVIFHRGDHVWDGNSFDSkFVYQQRGlgPIEEDTILVIDPNKaEILQSSGKNLFY 582
Cdd:cd14958    1 MVSSWPSASLKLGQVSGVAVDSLGNGVVFHRGGRVWDANSFDA-NVYVFKG--PIEEDTILVFDPDG-GFLRSWGAGLFY 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 583 LPHGLSIDTDGNYWVTDVALHQVFKLEPRSKEGPLLVLGRSMQPGSDQNHFCQPTDVAVEPsTGAVFVSDGYCNSRIVQF 662
Cdd:cd14958   77 MPHGLTIDPDGNIWVTDVGLHQVFKFDPEGKLLPLLTLGERGEPGSDQTHFCKPTDVAVAP-DGDIFVADGYCNSRIVKF 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 663 SPSGKFITQWGEESSGsspkPGQFSVPHSLALVPHlNQLCVADRENGRIQCFKTDTKeFVREIKHASFGRnVFAISYIP- 741
Cdd:cd14958  156 SPDGKLLKSWGEPGSG----PGQFNLPHSIALDED-GRVYVADRENGRIQVFDADGK-FLTEWTNPELGR-PYALAIDPd 228

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755493908 742 GFLFAVNGKPYFGDQEPVQGFVMNFSSGEIIDVFKPVR---KHFDMPHDIVASEDGTVYIGDAHTNTVWKFT 810
Cdd:cd14958  229 GLLYVVDGPPRLNRSLPVRGFVIRIGKGLILGRFGPGGkapGQFQNPHDIAVDSGGDIYVGELGPNRVQKFV 300
Cu2_monoox_C pfam03712
Copper type II ascorbate-dependent monooxygenase, C-terminal domain; The N and C-terminal ...
 200-346 3.13e-64

Copper type II ascorbate-dependent monooxygenase, C-terminal domain; The N and C-terminal domains of members of this family adopt the same PNGase F-like fold.


:

Pssm-ID: 461021  Cd Length: 157  Bit Score: 212.88  E-value: 3.13e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908  200 IAGMYLMMSV---NTVIPPGEKVVNSDISCHYK--MYPM-----HVFAYRVHTHHLGKVVSGYRVRNGQ-WTLIGRQSPQ 268
Cdd:pfam03712   2 DAGILLLGTVyspKMAIPPGQKVFHLEGYCTIDctDKALpesgiHPFASRLHTHLLGRVVSGYHVRDGQeWPLIGRDNPY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908  269 LP--QAFYPVEHPVDVAFGDILAARCVFTGEGRTEATHIGGTSSDEMCNLYIMYYmeakHAVSFMTCTQNVAPDMFRTIP 346
Cdd:pfam03712  82 SPhyQEFYPLEKEVTVLPGDVLAARCTYNTEDRTKVTLGGFTISDEMCNFYIMYY----PRTQLEVCKSSGPPEYLWNYF 157
Cu2_monooxygen pfam01082
Copper type II ascorbate-dependent monooxygenase, N-terminal domain; The N and C-terminal ...
 63-172 1.61e-26

Copper type II ascorbate-dependent monooxygenase, N-terminal domain; The N and C-terminal domains of members of this family adopt the same PNGase F-like fold.


:

Pssm-ID: 460053  Cd Length: 130  Bit Score: 105.41  E-value: 1.61e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908   63 LDIRMPGVT-PKESDTYFCMSMRLP-VDEEAFVIDFKP---RASMDTVHHMLLFGCnmPSSTGSYWFCDEGTCTDKAN-- 135
Cdd:pfam01082   1 FDLLNPNVTvPAKDTTYWCTVFKLPdLTKKHHIIRFEPviqPGNEGLVHHMLLYEC--EGDPNEPSPGYGGDCYSADNmp 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 755493908  136 --------ILYAWARNAPPTRLPKGVGFRVGGETGSKYFVLQVHY 172
Cdd:pfam01082  79 ddldpcssVIAAWAVGGGGFTYPEEVGLPIGGDGDPRYVMLEVHY 123
 
Name Accession Description Interval E-value
NHL_PAL_like cd14958
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the ...
 503-810 8.87e-148

Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the N-dealkylation of peptidyl-alpha-hydroxyglycine, which results in an alpha-amidated peptide and glyoxylate. Amidation of the C-terminus is required for the activity of many peptide hormones and neuropeptides. The catalytic residues of PAL are located on several NHL-repeats. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271328 [Multi-domain]  Cd Length: 300  Bit Score: 438.62  E-value: 8.87e-148
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 503 EALEWPGVYLLPGQVSGVALDSKNNLVIFHRGDHVWDGNSFDSkFVYQQRGlgPIEEDTILVIDPNKaEILQSSGKNLFY 582
Cdd:cd14958    1 MVSSWPSASLKLGQVSGVAVDSLGNGVVFHRGGRVWDANSFDA-NVYVFKG--PIEEDTILVFDPDG-GFLRSWGAGLFY 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 583 LPHGLSIDTDGNYWVTDVALHQVFKLEPRSKEGPLLVLGRSMQPGSDQNHFCQPTDVAVEPsTGAVFVSDGYCNSRIVQF 662
Cdd:cd14958   77 MPHGLTIDPDGNIWVTDVGLHQVFKFDPEGKLLPLLTLGERGEPGSDQTHFCKPTDVAVAP-DGDIFVADGYCNSRIVKF 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 663 SPSGKFITQWGEESSGsspkPGQFSVPHSLALVPHlNQLCVADRENGRIQCFKTDTKeFVREIKHASFGRnVFAISYIP- 741
Cdd:cd14958  156 SPDGKLLKSWGEPGSG----PGQFNLPHSIALDED-GRVYVADRENGRIQVFDADGK-FLTEWTNPELGR-PYALAIDPd 228

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755493908 742 GFLFAVNGKPYFGDQEPVQGFVMNFSSGEIIDVFKPVR---KHFDMPHDIVASEDGTVYIGDAHTNTVWKFT 810
Cdd:cd14958  229 GLLYVVDGPPRLNRSLPVRGFVIRIGKGLILGRFGPGGkapGQFQNPHDIAVDSGGDIYVGELGPNRVQKFV 300
Cu2_monoox_C pfam03712
Copper type II ascorbate-dependent monooxygenase, C-terminal domain; The N and C-terminal ...
 200-346 3.13e-64

Copper type II ascorbate-dependent monooxygenase, C-terminal domain; The N and C-terminal domains of members of this family adopt the same PNGase F-like fold.


Pssm-ID: 461021  Cd Length: 157  Bit Score: 212.88  E-value: 3.13e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908  200 IAGMYLMMSV---NTVIPPGEKVVNSDISCHYK--MYPM-----HVFAYRVHTHHLGKVVSGYRVRNGQ-WTLIGRQSPQ 268
Cdd:pfam03712   2 DAGILLLGTVyspKMAIPPGQKVFHLEGYCTIDctDKALpesgiHPFASRLHTHLLGRVVSGYHVRDGQeWPLIGRDNPY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908  269 LP--QAFYPVEHPVDVAFGDILAARCVFTGEGRTEATHIGGTSSDEMCNLYIMYYmeakHAVSFMTCTQNVAPDMFRTIP 346
Cdd:pfam03712  82 SPhyQEFYPLEKEVTVLPGDVLAARCTYNTEDRTKVTLGGFTISDEMCNFYIMYY----PRTQLEVCKSSGPPEYLWNYF 157
Cu2_monooxygen pfam01082
Copper type II ascorbate-dependent monooxygenase, N-terminal domain; The N and C-terminal ...
 63-172 1.61e-26

Copper type II ascorbate-dependent monooxygenase, N-terminal domain; The N and C-terminal domains of members of this family adopt the same PNGase F-like fold.


Pssm-ID: 460053  Cd Length: 130  Bit Score: 105.41  E-value: 1.61e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908   63 LDIRMPGVT-PKESDTYFCMSMRLP-VDEEAFVIDFKP---RASMDTVHHMLLFGCnmPSSTGSYWFCDEGTCTDKAN-- 135
Cdd:pfam01082   1 FDLLNPNVTvPAKDTTYWCTVFKLPdLTKKHHIIRFEPviqPGNEGLVHHMLLYEC--EGDPNEPSPGYGGDCYSADNmp 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 755493908  136 --------ILYAWARNAPPTRLPKGVGFRVGGETGSKYFVLQVHY 172
Cdd:pfam01082  79 ddldpcssVIAAWAVGGGGFTYPEEVGLPIGGDGDPRYVMLEVHY 123
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
560-810 2.06e-13

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 71.59  E-value: 2.06e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 560 DTILVIDPNKAEILQSSgKNLFYLPHGLSIDTDGNYWVTDVALHQVFKLEPRSKEgpllvLGRSMQPGSDQNhfcqPTDV 639
Cdd:COG4257   38 GRIGRLDPATGEFTEYP-LGGGSGPHGIAVDPDGNLWFTDNGNNRIGRIDPKTGE-----ITTFALPGGGSN----PHGI 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 640 AVEPStGAVFVSDGYcNSRIVQFSP-SGKFitqwgeeSSGSSPKPGQFsvPHSLALVPhLNQLCVADRENGRIQCFKTDT 718
Cdd:COG4257  108 AFDPD-GNLWFTDQG-GNRIGRLDPaTGEV-------TEFPLPTGGAG--PYGIAVDP-DGNLWVTDFGANAIGRIDPDT 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 719 KEFVREIKHASFGRNVfaisyipGFLFAVNGKPYFGDQEPVQGFVMNFSSGEIIDVFKPVRKHFdmPHDIVASEDGTVYI 798
Cdd:COG4257  176 GTLTEYALPTPGAGPR-------GLAVDPDGNLWVADTGSGRIGRFDPKTGTVTEYPLPGGGAR--PYGVAVDGDGRVWF 246

                        250
                 ....*....|..
gi 755493908 799 GDAHTNTVWKFT 810
Cdd:COG4257  247 AESGANRIVRFD 258
DUF5128 pfam17170
6-bladed beta-propeller; This family is a 6-bladed beta-propeller structure of unknown ...
 646-847 4.34e-05

6-bladed beta-propeller; This family is a 6-bladed beta-propeller structure of unknown function. There is a highly conserved FDxxG motif which might be important.


Pssm-ID: 407298 [Multi-domain]  Cd Length: 321  Bit Score: 46.55  E-value: 4.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908  646 GAVFVSDGYcNSRIVQFSPSGKFITQWGEESSGsspkPGQFSVPHSLALVPHLNQLCVADRENGRIQCFKTDTKEFVREI 725
Cdd:pfam17170  54 DRIFVFDSN-TNNLFVFDKKGKFVRQIGAQGNG----PGEYLQINDFIIDKSNNSIYILDFMQNKILTYDLDGYSFIGEI 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908  726 KHASFgrNVFAISYIPGFLFAVNGKPYFGDQEPVQgFVMNFSSGEIIDVFKPVRKHFDM---PHDIVASEDGTVYIGDAH 802
Cdd:pfam17170 129 NLDLL--PSDCCQLDKGKLAFDSSGFDDGKRSGFY-LVITDELGNIISGFFPAEFTLGIlfnSSVPFYEYGDNIYFYPYY 205

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 755493908  803 TNTVWKftLTESRLEVEHrSVKKAGIEVPEIkadhdRKLESSSGR 847
Cdd:pfam17170 206 SPTVYK--IMDGELKPAY-EFDFGGKKNPSI-----DFLKKIETK 242
 
Name Accession Description Interval E-value
NHL_PAL_like cd14958
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the ...
 503-810 8.87e-148

Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the N-dealkylation of peptidyl-alpha-hydroxyglycine, which results in an alpha-amidated peptide and glyoxylate. Amidation of the C-terminus is required for the activity of many peptide hormones and neuropeptides. The catalytic residues of PAL are located on several NHL-repeats. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271328 [Multi-domain]  Cd Length: 300  Bit Score: 438.62  E-value: 8.87e-148
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 503 EALEWPGVYLLPGQVSGVALDSKNNLVIFHRGDHVWDGNSFDSkFVYQQRGlgPIEEDTILVIDPNKaEILQSSGKNLFY 582
Cdd:cd14958    1 MVSSWPSASLKLGQVSGVAVDSLGNGVVFHRGGRVWDANSFDA-NVYVFKG--PIEEDTILVFDPDG-GFLRSWGAGLFY 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 583 LPHGLSIDTDGNYWVTDVALHQVFKLEPRSKEGPLLVLGRSMQPGSDQNHFCQPTDVAVEPsTGAVFVSDGYCNSRIVQF 662
Cdd:cd14958   77 MPHGLTIDPDGNIWVTDVGLHQVFKFDPEGKLLPLLTLGERGEPGSDQTHFCKPTDVAVAP-DGDIFVADGYCNSRIVKF 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 663 SPSGKFITQWGEESSGsspkPGQFSVPHSLALVPHlNQLCVADRENGRIQCFKTDTKeFVREIKHASFGRnVFAISYIP- 741
Cdd:cd14958  156 SPDGKLLKSWGEPGSG----PGQFNLPHSIALDED-GRVYVADRENGRIQVFDADGK-FLTEWTNPELGR-PYALAIDPd 228

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755493908 742 GFLFAVNGKPYFGDQEPVQGFVMNFSSGEIIDVFKPVR---KHFDMPHDIVASEDGTVYIGDAHTNTVWKFT 810
Cdd:cd14958  229 GLLYVVDGPPRLNRSLPVRGFVIRIGKGLILGRFGPGGkapGQFQNPHDIAVDSGGDIYVGELGPNRVQKFV 300
Cu2_monoox_C pfam03712
Copper type II ascorbate-dependent monooxygenase, C-terminal domain; The N and C-terminal ...
 200-346 3.13e-64

Copper type II ascorbate-dependent monooxygenase, C-terminal domain; The N and C-terminal domains of members of this family adopt the same PNGase F-like fold.


Pssm-ID: 461021  Cd Length: 157  Bit Score: 212.88  E-value: 3.13e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908  200 IAGMYLMMSV---NTVIPPGEKVVNSDISCHYK--MYPM-----HVFAYRVHTHHLGKVVSGYRVRNGQ-WTLIGRQSPQ 268
Cdd:pfam03712   2 DAGILLLGTVyspKMAIPPGQKVFHLEGYCTIDctDKALpesgiHPFASRLHTHLLGRVVSGYHVRDGQeWPLIGRDNPY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908  269 LP--QAFYPVEHPVDVAFGDILAARCVFTGEGRTEATHIGGTSSDEMCNLYIMYYmeakHAVSFMTCTQNVAPDMFRTIP 346
Cdd:pfam03712  82 SPhyQEFYPLEKEVTVLPGDVLAARCTYNTEDRTKVTLGGFTISDEMCNFYIMYY----PRTQLEVCKSSGPPEYLWNYF 157
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 518-809 3.31e-43

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 158.25  E-value: 3.31e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 518 SGVALDSKNNLVIFHRGDHvwdgnsfdskfvyqqrglgpieedTILVIDPNKAEILQ--SSGKNL--FYLPHGLSIDTDG 593
Cdd:cd05819   11 QGIAVDSSGNIYVADTGNN------------------------RIQVFDPDGNFITSfgSFGSGDgqFNEPAGVAVDSDG 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 594 NYWVTDVALHQVFKLeprSKEG-PLLVLGRSmqpGSDQNHFCQPTDVAVEPStGAVFVSDgYCNSRIVQFSPSGKFITQW 672
Cdd:cd05819   67 NLYVADTGNHRIQKF---DPDGnFLASFGGS---GDGDGEFNGPRGIAVDSS-GNIYVAD-TGNHRIQKFDPDGEFLTTF 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 673 GEESSGsspkPGQFSVPHSLALVPHlNQLCVADRENGRIQCFKTDTkEFVREIKHASFGRNVFaiSYIPGFLFAVNGKPY 752
Cdd:cd05819  139 GSGGSG----PGQFNGPTGVAVDSD-GNIYVADTGNHRIQVFDPDG-NFLTTFGSTGTGPGQF--NYPTGIAVDSDGNIY 210

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 755493908 753 FGDQEPVQGFVMNFSSGEIID--VFKPVRKHFDMPHDIVASEDGTVYIGDAHTNTVWKF 809
Cdd:cd05819  211 VADSGNNRVQVFDPDGAGFGGngNFLGSDGQFNRPSGLAVDSDGNLYVADTGNNRIQVF 269
Cu2_monooxygen pfam01082
Copper type II ascorbate-dependent monooxygenase, N-terminal domain; The N and C-terminal ...
 63-172 1.61e-26

Copper type II ascorbate-dependent monooxygenase, N-terminal domain; The N and C-terminal domains of members of this family adopt the same PNGase F-like fold.


Pssm-ID: 460053  Cd Length: 130  Bit Score: 105.41  E-value: 1.61e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908   63 LDIRMPGVT-PKESDTYFCMSMRLP-VDEEAFVIDFKP---RASMDTVHHMLLFGCnmPSSTGSYWFCDEGTCTDKAN-- 135
Cdd:pfam01082   1 FDLLNPNVTvPAKDTTYWCTVFKLPdLTKKHHIIRFEPviqPGNEGLVHHMLLYEC--EGDPNEPSPGYGGDCYSADNmp 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 755493908  136 --------ILYAWARNAPPTRLPKGVGFRVGGETGSKYFVLQVHY 172
Cdd:pfam01082  79 ddldpcssVIAAWAVGGGGFTYPEEVGLPIGGDGDPRYVMLEVHY 123
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 576-810 1.73e-25

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 107.28  E-value: 1.73e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 576 SGKNLFYLPHGLSIDTDGNYWVTDVALHQVFKLEprSKEGPLLVLGRSmqpGSDQNHFCQPTDVAVEpSTGAVFVSDGYc 655
Cdd:cd14955  104 SGDGQFNSPSGIAVDSAGNVYVTDSGNNRIQKFD--SSGTFITKWGSF---GSGDGQFNSPTGIAVD-SAGNVYVADTG- 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 656 NSRIVQFSPSGKFITQWGEESSGsspkPGQFSVPHSLAlVPHLNQLCVADRENGRIQCFKTDTkEFVreikhASFGrnvf 735
Cdd:cd14955  177 NNRIQKFTSTGTFLTKWGSEGSG----DGQFNAPYGIA-VDSAGNVYVADTGNNRIQKFDSSG-TFI-----TKWG---- 241

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755493908 736 aiSYIPGflfavngkpyfgdqepvqgfvmnfsSGEiidvfkpvrkhFDMPHDIVASEDGTVYIGDAHTNTVWKFT 810
Cdd:cd14955  242 --SEGSG-------------------------DGQ-----------FNSPSGIAVDSAGNVYVADSGNNRIQKFA 278
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 560-809 1.23e-23

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 101.59  E-value: 1.23e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 560 DTILVIDPNKAEI----LQSSGKNLFYLPHGLSIDTDGNYWVTDVALHQVFKLEPRSKegpllVLGRSMQPGSDQNHFCQ 635
Cdd:cd14956   81 DRIQVFTLTGELQtiggSSGSGPGQFNAPRGVAVDADGNLYVADFGNQRIQKFDPDGS-----FLRQWGGTGIEPGSFNY 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 636 PTDVAVEPStGAVFVSDGYcNSRIVQFSPSGKFITQWGEESSGsspkPGQFSVPHSLALVPhLNQLCVADRENGRIQCFK 715
Cdd:cd14956  156 PRGVAVDPD-GTLYVADTY-NDRIQVFDNDGAFLRKWGGRGTG----PGQFNYPYGIAIDP-DGNVFVADFGNNRIQKFT 228

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 716 TDtkefvreikhasfGRnvfaisyipgFLFAVNGKPyfgdQEPVQgfvmnfssgeiidvfkpvrkhFDMPHDIVASEDGT 795
Cdd:cd14956  229 AD-------------GT----------FLTSWGSPG----TGPGQ---------------------FKNPWGVVVDADGT 260

                        250
                 ....*....|....
gi 755493908 796 VYIGDAHTNTVWKF 809
Cdd:cd14956  261 VYVADSNNNRVQRF 274
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 518-714 1.74e-21

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 95.34  E-value: 1.74e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 518 SGVALDSKNNLvifhrgdHVWDGNS-----FDS--KFVYQQRGLGpieedtilvidpnkaeilqsSGKNLFYLPHGLSID 590
Cdd:cd14955  113 SGIAVDSAGNV-------YVTDSGNnriqkFDSsgTFITKWGSFG--------------------SGDGQFNSPTGIAVD 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 591 TDGNYWVTDVALHQVFKLEPRSkeGPLLVLGRsmqPGSDQNHFCQPTDVAVEpSTGAVFVSDGYcNSRIVQFSPSGKFIT 670
Cdd:cd14955  166 SAGNVYVADTGNNRIQKFTSTG--TFLTKWGS---EGSGDGQFNAPYGIAVD-SAGNVYVADTG-NNRIQKFDSSGTFIT 238

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 755493908 671 QWGEESSGsspkPGQFSVPHSLAlVPHLNQLCVADRENGRIQCF 714
Cdd:cd14955  239 KWGSEGSG----DGQFNSPSGIA-VDSAGNVYVADSGNNRIQKF 277
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 627-812 5.36e-21

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 94.18  E-value: 5.36e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 627 GSDQNHFCQPTDVAVEpSTGAVFVSDgYCNSRIVQFSPSGKFITQWGEESSGsspkPGQFSVPHSLALVPHLNqLCVADR 706
Cdd:cd14955    9 GSGDGQFNSPSGIAVD-SAGNVYVAD-TGNNRIQKFDSTGTFLTKWGSSGSG----DGQFYSPTGIAVDSDGN-VYVADT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 707 ENGRIQCFkTDTKEFVReiKHASFGRNVFAISYIPGFLFAVNGKPYFGDQ--EPVQ------GFVMNFSSGEIIDvfkpv 778
Cdd:cd14955   82 GNHRIQKF-DSTGTFLT--KWGSSGSGDGQFNSPSGIAVDSAGNVYVTDSgnNRIQkfdssgTFITKWGSFGSGD----- 153

                        170       180       190
                 ....*....|....*....|....*....|....
gi 755493908 779 rKHFDMPHDIVASEDGTVYIGDAHTNTVWKFTLT 812
Cdd:cd14955  154 -GQFNSPTGIAVDSAGNVYVADTGNNRIQKFTST 186
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 514-714 2.68e-18

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 85.80  E-value: 2.68e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 514 PGQ---VSGVALDSKNNLVI----FHRGDHVwdgnSFDSKFVYQ--QRGLGPIEedtilvidpnkaeilqssgknlFYLP 584
Cdd:cd14956  103 PGQfnaPRGVAVDADGNLYVadfgNQRIQKF----DPDGSFLRQwgGTGIEPGS----------------------FNYP 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 585 HGLSIDTDGNYWVTDVALH--QVFKLEPRskegPLLVLGrsmQPGSDQNHFCQPTDVAVEPStGAVFVSDGYcNSRIVQF 662
Cdd:cd14956  157 RGVAVDPDGTLYVADTYNDriQVFDNDGA----FLRKWG---GRGTGPGQFNYPYGIAIDPD-GNVFVADFG-NNRIQKF 227

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 755493908 663 SPSGKFITQWGEESSGsspkPGQFSVPHSLAlVPHLNQLCVADRENGRIQCF 714
Cdd:cd14956  228 TADGTFLTSWGSPGTG----PGQFKNPWGVV-VDADGTVYVADSNNNRVQRF 274
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 627-866 3.56e-17

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 82.72  E-value: 3.56e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 627 GSDQNHFCQPTDVAVepSTGAVFVSDGYcNSRIVQFSPSGKFITQWGEESSGsspkPGQFSVPHSLALVPHlNQLCVADR 706
Cdd:cd14963    3 GPFGDPLNKPMGVAV--SDGRIYVADTN-NHRVQVFDYEGKFKKSFGGPGTG----PGEFKYPYGIAVDSD-GNIYVADL 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 707 ENGRIQCFKTDTKeFVReikhaSFGRNVFAISYI-PGFLFAVNGKPYFGDQEPVQGFVMNFSSGEIIDVFKPVRK--HFD 783
Cdd:cd14963   75 YNGRIQVFDPDGK-FLK-----YFPEKKDRVKLIsPAGLAIDDGKLYVSDVKKHKVIVFDLEGKLLLEFGKPGSEpgELS 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 784 MPHDIVASEDGTVYIGDAHTNTVWKFTLTESRL-EVEHRSVKKAGIEVPE-IKADHDRKL---ESSSGRVLG-RLRGK-- 855
Cdd:cd14963  149 YPNGIAVDEDGNIYVADSGNGRIQVFDKNGKFIkELNGSPDGKSGFVNPRgIAVDPDGNLyvvDNLSHRVYVfDEQGKel 228

                        250
                 ....*....|....
gi 755493908 856 ---GSSGLNLGNFF 866
Cdd:cd14963  229 ftfGGRGKDDGQFN 242
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 576-800 4.64e-17

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 82.34  E-value: 4.64e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 576 SGKNLFYLPHGLSIDTDGNYWVTDVA--LHQVFkleprSKEGPLLvlgRSMQPGSDQNHFCQPTDVAVepSTGAVFVSD- 652
Cdd:cd14963   50 TGPGEFKYPYGIAVDSDGNIYVADLYngRIQVF-----DPDGKFL---KYFPEKKDRVKLISPAGLAI--DDGKLYVSDv 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 653 GYcnSRIVQFSPSGKFITQWGEESSGsspkPGQFSVPHSLALVPHlNQLCVADRENGRIQCFKTDTKeFVREIKHASFGR 732
Cdd:cd14963  120 KK--HKVIVFDLEGKLLLEFGKPGSE----PGELSYPNGIAVDED-GNIYVADSGNGRIQVFDKNGK-FIKELNGSPDGK 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755493908 733 NVFA----ISYIP-GFLFAVN---GKPYFGDQEPVQGFVMNfSSGEIIDVFKpvrkhfdMPHDIVASEDGTVYIGD 800
Cdd:cd14963  192 SGFVnprgIAVDPdGNLYVVDnlsHRVYVFDEQGKELFTFG-GRGKDDGQFN-------LPNGLFIDDDGRLYVTD 259
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 577-732 9.56e-17

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 81.48  E-value: 9.56e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 577 GKNLFYLPHGLSIDTDGNYWVTDVALHQVFKLEPrsKEGPLLVLGRSMQpgsdqnhFCQPTDVAVEPSTGAVFVSDGYcN 656
Cdd:cd14962   52 GPNRFVSPIGVAIDANGNLYVSDAELGKVFVFDR--DGKFLRAIGAGAL-------FKRPTGIAVDPAGKRLYVVDTL-A 121

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755493908 657 SRIVQFSPSGKFITQWGEESSGsspkPGQFSVPHSLALVPHLNqLCVADRENGRIQCFKTDTKeFVReikhaSFGR 732
Cdd:cd14962  122 HKVKVFDLDGRLLFDIGKRGSG----PGEFNLPTDLAVDRDGN-LYVTDTMNFRVQIFDADGK-FLR-----SFGE 186
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 575-810 3.14e-16

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 80.00  E-value: 3.14e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 575 SSGKNLFYLPHGLSIDTDGNYWVTDVALH--QVFkleprSKEGPLLVLGRSmqPGSDQNHFCQPTDVAVEpSTGAVFVSD 652
Cdd:cd14957   11 GSGNGQFNTPRGIAVDSAGNIYVADTGNNriQVF-----TSSGVYSYSIGS--GGTGSGQFNSPYGIAVD-SNGNIYVAD 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 653 gYCNSRIVQFSPSGKFITQWGeeSSGSSpkPGQFSVPHSLALVPHLNqLCVADRENGRIQCFkTDTKEFVREIKHASFGR 732
Cdd:cd14957   83 -TDNNRIQVFNSSGVYQYSIG--TGGSG--DGQFNGPYGIAVDSNGN-IYVADTGNHRIQVF-TSSGTFSYSIGSGGTGP 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 733 NVFaiSYIPGFLFAVNGKPYFGDQ--EPVQGFVmnfSSGEIIDVF---KPVRKHFDMPHDIVASEDGTVYIGDAHTNTVW 807
Cdd:cd14957  156 GQF--NGPQGIAVDSDGNIYVADTgnHRIQVFT---SSGTFQYTFgssGSGPGQFSDPYGIAVDSDGNIYVADTGNHRIQ 230


                 ...
gi 755493908 808 KFT 810
Cdd:cd14957  231 VFT 233
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 519-714 2.10e-15

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 77.59  E-value: 2.10e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 519 GVALDSKNNLVIFHRGDH---VWDGN-SFDSKFVYQQRGLGPIEEdtilvidpnkaeilqssgknlfylPHGLSIDTDGN 594
Cdd:cd14954  122 GVAVDSEGRIYVSDTRNHrvqVFDSDgQFIRKFGFEGAGPGQLDS------------------------PRGVAVNPDGN 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 595 YWVTDVALHQVFKLEPRSKegPLLVLGrsmQPGSDQNHFCQPTDVAVEPStGAVFVSDGYcNSRIVQFSPSGKFITQWGE 674
Cdd:cd14954  178 IVVSDFNNHRLQVFDPDGQ--FLRFFG---SEGSGNGQFKRPRGVAVDDE-GNIIVADSG-NHRVQVFSPDGEFLCSFGT 250

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 755493908 675 ESSGsspkPGQFSVPHSLALVPHLNqLCVADRENGRIQCF 714
Cdd:cd14954  251 EGNG----EGQFDRPSGVAVTPDGR-IVVVDRGNHRIQVF 285
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 581-812 2.40e-15

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 77.32  E-value: 2.40e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 581 FYLPHGLSIDTDGNYWVTDVALH--QVFkleprSKEGPLLvlGRSMQPGSDQNHFCQPTDVAVEPsTGAVFVSDgYCNSR 658
Cdd:cd14956   12 FKDPRGIAVDADDNVYVADARNGriQVF-----DKDGTFL--RRFGTTGDGPGQFGRPRGLAVDK-DGWLYVAD-YWGDR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 659 IVQFSPSGKFITQWGEESSGsspkPGQFSVPHSLALVPHLNqLCVADRENGRIQCFKTDTKeFVREIkhasfgrnvfais 738
Cdd:cd14956   83 IQVFTLTGELQTIGGSSGSG----PGQFNAPRGVAVDADGN-LYVADFGNQRIQKFDPDGS-FLRQW------------- 143

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755493908 739 yipgflfavnGKPyfgDQEPVQgfvmnfssgeiidvfkpvrkhFDMPHDIVASEDGTVYIGDAHTNTVWKFTLT 812
Cdd:cd14956  144 ----------GGT---GIEPGS---------------------FNYPRGVAVDPDGTLYVADTYNDRIQVFDND 183
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 575-714 3.42e-15

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 76.92  E-value: 3.42e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 575 SSGKNLFYLPHGLSIDTDGNYWVTDVALH--QVFkleprSKEGpllVLGRSM-QPGSDQNHFCQPTDVAVEpSTGAVFVS 651
Cdd:cd14957  152 GTGPGQFNGPQGIAVDSDGNIYVADTGNHriQVF-----TSSG---TFQYTFgSSGSGPGQFSDPYGIAVD-SDGNIYVA 222

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755493908 652 DgYCNSRIVQFSPSGKFITQWGeeSSGSSpkPGQFSVPHSLAlVPHLNQLCVADRENGRIQCF 714
Cdd:cd14957  223 D-TGNHRIQVFTSSGAYQYSIG--TSGSG--NGQFNYPYGIA-VDNDGKIYVADSNNNRIQVF 279
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 575-806 9.57e-14

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 72.68  E-value: 9.57e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 575 SSGKNLFYLPHGLSIDTDGNYWVTDVALH--QVFKleprSKEGPLLVLGRSmqpGSDQNHFCQPTDVAVEpSTGAVFVSD 652
Cdd:cd14957   58 GTGSGQFNSPYGIAVDSNGNIYVADTDNNriQVFN----SSGVYQYSIGTG---GSGDGQFNGPYGIAVD-SNGNIYVAD 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 653 GYcNSRIVQFSPSGKFITQWGEESSGsspkPGQFSVPHSLALVPHLNqLCVADRENGRIQCFkTDTKEFVREIKHASFGR 732
Cdd:cd14957  130 TG-NHRIQVFTSSGTFSYSIGSGGTG----PGQFNGPQGIAVDSDGN-IYVADTGNHRIQVF-TSSGTFQYTFGSSGSGP 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 733 NVFAISY-IpgflfAV--NGKPYFGDQ--EPVQ------GFVMNFSSGEIIDvfkpvrKHFDMPHDIVASEDGTVYIGDA 801
Cdd:cd14957  203 GQFSDPYgI-----AVdsDGNIYVADTgnHRIQvftssgAYQYSIGTSGSGN------GQFNYPYGIAVDNDGKIYVADS 271


                 ....*
gi 755493908 802 HTNTV 806
Cdd:cd14957  272 NNNRI 276
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
560-810 2.06e-13

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 71.59  E-value: 2.06e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 560 DTILVIDPNKAEILQSSgKNLFYLPHGLSIDTDGNYWVTDVALHQVFKLEPRSKEgpllvLGRSMQPGSDQNhfcqPTDV 639
Cdd:COG4257   38 GRIGRLDPATGEFTEYP-LGGGSGPHGIAVDPDGNLWFTDNGNNRIGRIDPKTGE-----ITTFALPGGGSN----PHGI 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 640 AVEPStGAVFVSDGYcNSRIVQFSP-SGKFitqwgeeSSGSSPKPGQFsvPHSLALVPhLNQLCVADRENGRIQCFKTDT 718
Cdd:COG4257  108 AFDPD-GNLWFTDQG-GNRIGRLDPaTGEV-------TEFPLPTGGAG--PYGIAVDP-DGNLWVTDFGANAIGRIDPDT 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 719 KEFVREIKHASFGRNVfaisyipGFLFAVNGKPYFGDQEPVQGFVMNFSSGEIIDVFKPVRKHFdmPHDIVASEDGTVYI 798
Cdd:COG4257  176 GTLTEYALPTPGAGPR-------GLAVDPDGNLWVADTGSGRIGRFDPKTGTVTEYPLPGGGAR--PYGVAVDGDGRVWF 246

                        250
                 ....*....|..
gi 755493908 799 GDAHTNTVWKFT 810
Cdd:COG4257  247 AESGANRIVRFD 258
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 581-806 1.50e-12

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 69.11  E-value: 1.50e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 581 FYLPHGLSIDTDGNYWVTDVALH--QVFKleprsKEGPLL-VLGRSmqpGSDQNHFCQPTDVAVEpSTGAVFVSDGYcNS 657
Cdd:cd14954   23 LCRPWGVAVDKDGRIIVADRSNNrvQVFD-----PDGKFLrKFGSY---GSRDGQFDRPAGVAVN-SRGRIIVADKD-NH 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 658 RIVQFSPSGKFITQWGEESSgsspKPGQFSVPHSLAlVPHLNQLCVADRENGRIQCFKTDTKeFVREI-------KHASF 730
Cdd:cd14954   93 RIQVFDLNGRFLLKFGERGT----KNGQFNYPWGVA-VDSEGRIYVSDTRNHRVQVFDSDGQ-FIRKFgfegagpGQLDS 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 731 GRNVfAIS-----YIPGF------LFAVNGKP--YFGDQEPVQGFvMNFSSGEIID----------------VFKP---- 777
Cdd:cd14954  167 PRGV-AVNpdgniVVSDFnnhrlqVFDPDGQFlrFFGSEGSGNGQ-FKRPRGVAVDdegniivadsgnhrvqVFSPdgef 244

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 755493908 778 VRK---------HFDMPHDIVASEDGTVYIGDAHTNTV 806
Cdd:cd14954  245 LCSfgtegngegQFDRPSGVAVTPDGRIVVVDRGNHRI 282
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 552-735 7.58e-12

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 66.80  E-value: 7.58e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 552 RGLGPIEEDTILVIDP--NKAEILQSSGKNL------------FYLPHGLSIDTDGNYWVTDVALH--QVFKLEPRSkeg 615
Cdd:cd14954   27 WGVAVDKDGRIIVADRsnNRVQVFDPDGKFLrkfgsygsrdgqFDRPAGVAVNSRGRIIVADKDNHriQVFDLNGRF--- 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 616 pLLVLGRSmqpGSDQNHFCQPTDVAVEpSTGAVFVSDGYcNSRIVQFSPSGKFITQWGEESSGsspkPGQFSVPHSLAlV 695
Cdd:cd14954  104 -LLKFGER---GTKNGQFNYPWGVAVD-SEGRIYVSDTR-NHRVQVFDSDGQFIRKFGFEGAG----PGQLDSPRGVA-V 172

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 755493908 696 PHLNQLCVADRENGRIQCFKTDTKeFVREIKHASFGRNVF 735
Cdd:cd14954  173 NPDGNIVVSDFNNHRLQVFDPDGQ-FLRFFGSEGSGNGQF 211
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 514-714 9.03e-12

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 66.80  E-value: 9.03e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 514 PGQV---SGVALDSKNNLVIFHRGDH---VWDGN-SFDSKFvyQQRGlgpieedtilvidpnkaeilQSSGKnlFYLPHG 586
Cdd:cd14954   67 DGQFdrpAGVAVNSRGRIIVADKDNHriqVFDLNgRFLLKF--GERG--------------------TKNGQ--FNYPWG 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 587 LSIDTDGNYWVTDVALH--QVFkleprSKEGPLLvlgrsMQPGSDQN---HFCQPTDVAVEPsTGAVFVSDgYCNSRIVQ 661
Cdd:cd14954  123 VAVDSEGRIYVSDTRNHrvQVF-----DSDGQFI-----RKFGFEGAgpgQLDSPRGVAVNP-DGNIVVSD-FNNHRLQV 190

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 755493908 662 FSPSGKFITQWGEESSGsspkPGQFSVPHSLALVPHLNQLcVADRENGRIQCF 714
Cdd:cd14954  191 FDPDGQFLRFFGSEGSG----NGQFKRPRGVAVDDEGNII-VADSGNHRVQVF 238
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
584-809 1.61e-11

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 65.81  E-value: 1.61e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 584 PHGLSIDTDGNYWVTDVALHQVFKLEPRSKEGPLLVLGRsmqpgsdqnhFCQPTDVAVEPStGAVFVSDGYcNSRIVQFS 663
Cdd:COG4257   19 PRDVAVDPDGAVWFTDQGGGRIGRLDPATGEFTEYPLGG----------GSGPHGIAVDPD-GNLWFTDNG-NNRIGRID 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 664 PSGKFITQWgeessgssPKPGQFSVPHSLALVPHlNQLCVADRENGRIQCFKTDTKEfVREIKHASFGRNVFAISYIPgf 743
Cdd:COG4257   87 PKTGEITTF--------ALPGGGSNPHGIAFDPD-GNLWFTDQGGNRIGRLDPATGE-VTEFPLPTGGAGPYGIAVDP-- 154

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755493908 744 lfavNGKPYFGDQEPVQGFVMNFSSGEiIDVFKPVRKhFDMPHDIVASEDGTVYIGDAHTNTVWKF 809
Cdd:COG4257  155 ----DGNLWVTDFGANAIGRIDPDTGT-LTEYALPTP-GAGPRGLAVDPDGNLWVADTGSGRIGRF 214
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 562-714 5.75e-11

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 64.15  E-value: 5.75e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 562 ILVIDPNKAEILQSSGKNLFYLPHGLSIDTDGNY-WVTDVALHQVFKLEPRSKEgpllvLGRSMQPGSDQNHFCQPTDVA 640
Cdd:cd14962   80 VFVFDRDGKFLRAIGAGALFKRPTGIAVDPAGKRlYVVDTLAHKVKVFDLDGRL-----LFDIGKRGSGPGEFNLPTDLA 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 641 VEPStGAVFVSDGYcNSRIVQFSPSGKFITQWGE-------------------------ESS------------------ 677
Cdd:cd14962  155 VDRD-GNLYVTDTM-NFRVQIFDADGKFLRSFGErgdgpgsfarpkgiavdsegniyvvDAAfdnvqifnpegellltvg 232

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 755493908 678 GSSPKPGQFSVPHSLAlVPHLNQLCVADRENGRIQCF 714
Cdd:cd14962  233 GPGSGPGEFYLPSGIA-IDKDDRIYVVDQFNRRIQVF 268
NHL_TRIM32_like cd14961
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ...
 507-718 2.23e-10

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271331 [Multi-domain]  Cd Length: 273  Bit Score: 62.29  E-value: 2.23e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 507 WPGVYLLPgqvSGVALDSKNNLVIFHrgdhvwDGNS----FDSKFVYQQRgLGPIEEDT--------------------- 561
Cdd:cd14961    6 WPGTLNNP---TGVAVTPTGRVVVAD------DGNKriqvFDSDGNCLQQ-FGPKGDAGqdirypldvavtpdghivvtd 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 562 -----ILVIDPNKaEILQSSGKNlFYLPHGLSIDTDGNYWVTDVALHQVFKLEPRSKEGPLLVLGRSmqpgsdQNHFCQP 636
Cdd:cd14961   76 agdrsVKVFSFDG-RLKLFVRKS-FSLPWGVAVNPSGEILVTDSEAGKLFVLTVDFKLGILKKGQKL------CSQLCRP 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 637 TDVAVEPStGAVFVSD-------GYCNSRIVQFSPSGKFITQWGeeSSGSSPKPGQFSVPHSLAlVPHLNQLCVADRENG 709
Cdd:cd14961  148 RFVAVSRL-GAVAVTEhlfangtRSSSTRVKVFSSGGQLLGQID--SFGLNLVFPSLICASGVA-FDSEGNVIVADTGSG 223


                 ....*....
gi 755493908 710 RIQCFKTDT 718
Cdd:cd14961  224 AILCLGKPE 232
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 518-711 3.04e-10

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 62.55  E-value: 3.04e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 518 SGVALDSKNNLVIFHRGDHvwdgnsfdskfvyqqrglgpieedTILVIDPN-KAEILQSSGK----------NLFYLPHG 586
Cdd:cd14953   26 SGVAVDAAGNLYVADRGNH------------------------RIRKITPDgVVTTVAGTGTagfadgggaaAQFNTPSG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 587 LSIDTDGNYWVTDVALHQVFKLEPrskEGPLLVL------GRSMQPGSDQNHFCQPTDVAVEPStGAVFVSDGYcNSRIV 660
Cdd:cd14953   82 VAVDAAGNLYVADTGNHRIRKITP---DGVVSTLagtgtaGFSDDGGATAAQFNYPTGVAVDAA-GNLYVADTG-NHRIR 156

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 755493908 661 QFSPSGKFITQWGEESSGSSP-KPG---QFSVPHSLALVPHLNqLCVADRENGRI 711
Cdd:cd14953  157 KITPDGVVTTVAGTGGAGYAGdGPAtaaQFNNPTGVAVDAAGN-LYVADRGNHRI 210
NHL_TRIM2_like cd14960
NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; ...
 584-715 2.11e-09

NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; The E3 ubiquitin-protein ligase TRIM2 is responsible for ubiquinating the apoptosis-inducing Bcl-2-interacting mediator of cell death (Bim), when the latter is phosphorylated by p42/p44 MAPK. TRIM2 regulates the ubiquitination of neurofilament light subunit (NF-L), deficiencies in TRIM2 result in increased NF-L levels in axons and subsequent axonopathy. TRIM2 is also involved in regulating axon outgrowth during development; it contains RING and BBOX domains, the NHL repeat domain is located at its C-terminus. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271330 [Multi-domain]  Cd Length: 274  Bit Score: 59.28  E-value: 2.11e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 584 PHGLSIDTDGNYWVTDVALHQVFKLEPRSKegpllVLGRSMQPGSDQNHFCQPTDVAVEpSTGAVFVSDgYCNSRIVQFS 663
Cdd:cd14960  108 PKGVAVDRNGHIIVVDNKACCVFIFQPNGK-----LVTRFGSRGNGDRQFAGPHFAAVN-NNNEIIVTD-FHNHSVKVFN 180

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 755493908 664 PSGKFITQWGEESSGsspkPGQFSVPHSLALVPHLNqLCVADRENGRIQCFK 715
Cdd:cd14960  181 AEGEFLFKFGSNGEG----NGQFNAPTGVAVDSNGN-IIVADWGNSRIQVFD 227
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 508-714 3.31e-09

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 58.84  E-value: 3.31e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 508 PGVYLLPgqvSGVALDSKNNLVI---FHRGDHVWD--GNsFDSKFVYQQRGLGP-------IEEDTILVID--PNKAEIL 573
Cdd:cd14963   52 PGEFKYP---YGIAVDSDGNIYVadlYNGRIQVFDpdGK-FLKYFPEKKDRVKLispaglaIDDGKLYVSDvkKHKVIVF 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 574 QSSGKNLFYL------------PHGLSIDTDGNYWVTDVALH--QVFkleprSKEGPLL--VLGRSMQPGSdqnhFCQPT 637
Cdd:cd14963  128 DLEGKLLLEFgkpgsepgelsyPNGIAVDEDGNIYVADSGNGriQVF-----DKNGKFIkeLNGSPDGKSG----FVNPR 198

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755493908 638 DVAVEPsTGAVFVSDGYCNsRIVQFSPSGKFITQWGeeSSGSSPkpGQFSVPHSLALVPHlNQLCVADRENGRIQCF 714
Cdd:cd14963  199 GIAVDP-DGNLYVVDNLSH-RVYVFDEQGKELFTFG--GRGKDD--GQFNLPNGLFIDDD-GRLYVTDRENNRVAVY 268
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
648-806 9.60e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 53.93  E-value: 9.60e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 648 VFVSDGYcNSRIVQFSP-SGKFITQWgeeSSGSSPkpgqfsvpHSLALVPHLNQLCVADRENGRIQCFKTDTKEFVREIK 726
Cdd:COG3391   82 LYVANSG-SGRVSVIDLaTGKVVATI---PVGGGP--------RGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIP 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 727 hasFGRNVFAISYIP--GFLFAVNgkpyFGDQEpVQGFV--MNFSSGEIIDVFKPvrkhFDMPHDIVASEDG-TVYIGDA 801
Cdd:COG3391  150 ---VGAGPHGIAVDPdgKRLYVAN----SGSNT-VSVIVsvIDTATGKVVATIPV----GGGPVGVAVSPDGrRLYVANR 217


                 ....*
gi 755493908 802 HTNTV 806
Cdd:COG3391  218 GSNTS 222
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 580-711 1.91e-07

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 54.07  E-value: 1.91e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 580 LFYLPHGLSIDTDGNYWVTDVALHQVFKLEPRSKEGPllVLGRSMQPGSDQNH-----FCQPTDVAVEpSTGAVFVSDgY 654
Cdd:cd14953  185 QFNNPTGVAVDAAGNLYVADRGNHRIRKITPDGVVTT--VAGTGTAGFSGDGGataaqLNNPTGVAVD-AAGNLYVAD-S 260

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755493908 655 CNSRIVQFSPSGKFIT----QWGEESSGSSPKPGQFSVPHSLALVPHLNqLCVADRENGRI 711
Cdd:cd14953  261 GNHRIRKITPAGVVTTvaggGAGFSGDGGPATSAQFNNPTGVAVDAAGN-LYVADTGNNRI 320
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 581-810 2.06e-07

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 53.69  E-value: 2.06e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 581 FYLPHGLSIDTDGNYWVTDVALHQVFKLeprSKEGPLLVLGRSMQPGSD-----QNHFCQPTDVAVEPStGAVFVSDGYc 655
Cdd:cd14953   22 FNSPSGVAVDAAGNLYVADRGNHRIRKI---TPDGVVTTVAGTGTAGFAdgggaAAQFNTPSGVAVDAA-GNLYVADTG- 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 656 NSRIVQFSPSGKFITQWGEESSGSSPKPG----QFSVPHSLALVPHLNqLCVADRENGRIQcfKTDTKEFVReikhasfg 731
Cdd:cd14953   97 NHRIRKITPDGVVSTLAGTGTAGFSDDGGataaQFNYPTGVAVDAAGN-LYVADTGNHRIR--KITPDGVVT-------- 165

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755493908 732 rnVFAISYIPGFLFAVNGkpyfgdqepvqgfvmnfssgeiidvfkpVRKHFDMPHDIVASEDGTVYIGDAHTNTVWKFT 810
Cdd:cd14953  166 --TVAGTGGAGYAGDGPA----------------------------TAAQFNNPTGVAVDAAGNLYVADRGNHRIRKIT 214
NHL_brat_like cd14959
NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins; ...
 627-800 3.65e-07

NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins; Drosophila brain-tumor (brat) has been identified as a tumor suppressor that negatively regulates cell proliferation during development of the Drosophila larval brain. It appears to be recruited to the 3'-untranslated region of hunchback RNA and regulates its translation by forming a complex with Pumilio (Pum) and Nanos (Nos). The NHL domain of brat appears to be involved by interacting with the RNA-binding Puf repeats of Pumilio, a sequence-specific RNA binding protein. This family also contains the Caenorhabditis elegans homolog NCL-1. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271329 [Multi-domain]  Cd Length: 274  Bit Score: 52.66  E-value: 3.65e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 627 GSDQNHFCQPTDVAVEpSTGAVFVSDGYcNSRIVQFSPSGKFITQWGEESSgsspKPGQFSVPHSLALVPHLNQLCVADR 706
Cdd:cd14959   15 GSGEGQFNSPSGFCLG-EDEDILVADTN-NHRIQVFDKEGEFKFQFGIPGK----RDGQLWYPNKVAVCRVTGRYVVTDR 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 707 ENG--RIQCFkTDTKEFVREikhasfgrnvFAISYI--PGFLfAVNGKPYFGDQEPVQGFVMNFS-SGEIIDVFKpVRKH 781
Cdd:cd14959   89 GNPrhRMQIF-TKRGQFVRK----------FGARYLqhVRGL-TVDAAGHIIVVESKVMRVFIFDeSGNVLKWFD-CSKY 155

                        170
                 ....*....|....*....
gi 755493908 782 FDMPHDIVASeDGTVYIGD 800
Cdd:cd14959  156 LEEPSDVAVN-DNEIYICD 173
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 584-711 3.89e-07

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 52.21  E-value: 3.89e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 584 PHGLSIDTDGNYWVTDVALHQVFKLEPRSKEGPLLvlgrsmqPGSDQNhfcQPTDVAVEpSTGAVFVSDGYcNSRIVQFS 663
Cdd:cd14952   12 PGGVAVDAAGNVYVADSGNNRVLKLAAGSTTQTVL-------PFTGLY---QPQGVAVD-AAGTVYVTDFG-NNRVLKLA 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 755493908 664 PsgkfitqwgeessGSS-PKPGQF---SVPHSLALVPHLNqLCVADRENGRI 711
Cdd:cd14952   80 A-------------GSTtQTVLPFtglNDPTGVAVDAAGN-VYVADTGNNRV 117
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 584-661 2.23e-06

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 49.90  E-value: 2.23e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755493908 584 PHGLSIDTDGNYWVTDVALHQVFKLEPRSKEgpLLVLgrsmqPGSDQNHfcqPTDVAVEpSTGAVFVSDgYCNSRIVQ 661
Cdd:cd14952  180 PSGVAVDTAGNVYVTDHGNNRVLKLAAGSTT--PTVL-----PFTGLNG---PLGVAVD-AAGNVYVAD-RGNDRVVK 245
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
590-749 2.40e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 49.69  E-value: 2.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 590 DTDGNY-WVTDVALHQVFKLEPRSKEgpllvLGRSMQPGSDqnhfcqPTDVAVEPSTGAVFVSDGYcNSRIVQFSP-SGK 667
Cdd:COG3391   76 GADGRRlYVANSGSGRVSVIDLATGK-----VVATIPVGGG------PRGLAVDPDGGRLYVADSG-NGRVSVIDTaTGK 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 668 FITQWgeeSSGSSpkpgqfsvPHSLALVPHLNQLCVADRENGRI----QCFKTDTKEFVREIkhaSFGRNVFAISYIP-- 741
Cdd:COG3391  144 VVATI---PVGAG--------PHGIAVDPDGKRLYVANSGSNTVsvivSVIDTATGKVVATI---PVGGGPVGVAVSPdg 209


                 ....*...
gi 755493908 742 GFLFAVNG 749
Cdd:COG3391  210 RRLYVANR 217
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
699-809 8.26e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 48.15  E-value: 8.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 699 NQLCVADRENGRIQCFKTDTKEFVREIKHASFGRNVfAISYIPGFLFAVNGKPYFgdqepVQgfVMNFSSGEIIDVFKPv 778
Cdd:COG3391   80 RRLYVANSGSGRVSVIDLATGKVVATIPVGGGPRGL-AVDPDGGRLYVADSGNGR-----VS--VIDTATGKVVATIPV- 150

                         90       100       110
                 ....*....|....*....|....*....|..
gi 755493908 779 rkhFDMPHDIVASEDG-TVYIGDAHTNTVWKF 809
Cdd:COG3391  151 ---GAGPHGIAVDPDGkRLYVANSGSNTVSVI 179
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 668-810 1.82e-05

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 47.57  E-value: 1.82e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 668 FITQWGEESSGSspkpGQFSVPHSLAlVPHLNQLCVADRENGRIQCFKTDtkefvreikhasfgrnvfaisyipGFLFAV 747
Cdd:cd14955    1 FVTQWGSYGSGD----GQFNSPSGIA-VDSAGNVYVADTGNNRIQKFDST------------------------GTFLTK 51

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755493908 748 NGKPYFGDqepvqgfvmnfssGEiidvfkpvrkhFDMPHDIVASEDGTVYIGDAHTNTVWKFT 810
Cdd:cd14955   52 WGSSGSGD-------------GQ-----------FYSPTGIAVDSDGNVYVADTGNHRIQKFD 90
NHL_brat_like cd14959
NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins; ...
 576-669 3.82e-05

NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins; Drosophila brain-tumor (brat) has been identified as a tumor suppressor that negatively regulates cell proliferation during development of the Drosophila larval brain. It appears to be recruited to the 3'-untranslated region of hunchback RNA and regulates its translation by forming a complex with Pumilio (Pum) and Nanos (Nos). The NHL domain of brat appears to be involved by interacting with the RNA-binding Puf repeats of Pumilio, a sequence-specific RNA binding protein. This family also contains the Caenorhabditis elegans homolog NCL-1. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271329 [Multi-domain]  Cd Length: 274  Bit Score: 46.49  E-value: 3.82e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 576 SGKNLFYLPHGLSIDTDGNYWVTDVALH--QVFkleprSKEGPLLvlgrsMQ---PGSDQNHFCQPTDVAVEPSTGAVFV 650
Cdd:cd14959   16 SGEGQFNSPSGFCLGEDEDILVADTNNHriQVF-----DKEGEFK-----FQfgiPGKRDGQLWYPNKVAVCRVTGRYVV 85

                         90       100
                 ....*....|....*....|
gi 755493908 651 SD-GYCNSRIVQFSPSGKFI 669
Cdd:cd14959   86 TDrGNPRHRMQIFTKRGQFV 105
NHL_TRIM2_like cd14960
NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; ...
 514-715 4.08e-05

NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; The E3 ubiquitin-protein ligase TRIM2 is responsible for ubiquinating the apoptosis-inducing Bcl-2-interacting mediator of cell death (Bim), when the latter is phosphorylated by p42/p44 MAPK. TRIM2 regulates the ubiquitination of neurofilament light subunit (NF-L), deficiencies in TRIM2 result in increased NF-L levels in axons and subsequent axonopathy. TRIM2 is also involved in regulating axon outgrowth during development; it contains RING and BBOX domains, the NHL repeat domain is located at its C-terminus. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271330 [Multi-domain]  Cd Length: 274  Bit Score: 46.18  E-value: 4.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 514 PGQV---SGVALDSKNNLVIFHRGDHvW------DGnSFDSKFvYQQRGLGPI-----EEDTILVIDpNKA---EILQSS 576
Cdd:cd14960   60 PGQLqrpTGVAVTLNGDIIIADYDNK-WvsifspDG-KFKSKI-GAGKLMGPKgvavdRNGHIIVVD-NKAccvFIFQPN 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 577 GK------------NLFYLPHGLSIDTDGNYWVTDVALHQVfKLepRSKEGPLLVLGRSMQPGSDQnhFCQPTDVAVEpS 644
Cdd:cd14960  136 GKlvtrfgsrgngdRQFAGPHFAAVNNNNEIIVTDFHNHSV-KV--FNAEGEFLFKFGSNGEGNGQ--FNAPTGVAVD-S 209

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755493908 645 TGAVFVSDgYCNSRIVQFSPSGKFitqwgEESSGSSPKPgqFSVPHSLALVPHlNQLCVADRENgriQCFK 715
Cdd:cd14960  210 NGNIIVAD-WGNSRIQVFDSSGSF-----LSYINTSADP--LYGPQGLALTSD-GHVVVADSGN---HCFK 268
DUF5128 pfam17170
6-bladed beta-propeller; This family is a 6-bladed beta-propeller structure of unknown ...
 646-847 4.34e-05

6-bladed beta-propeller; This family is a 6-bladed beta-propeller structure of unknown function. There is a highly conserved FDxxG motif which might be important.


Pssm-ID: 407298 [Multi-domain]  Cd Length: 321  Bit Score: 46.55  E-value: 4.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908  646 GAVFVSDGYcNSRIVQFSPSGKFITQWGEESSGsspkPGQFSVPHSLALVPHLNQLCVADRENGRIQCFKTDTKEFVREI 725
Cdd:pfam17170  54 DRIFVFDSN-TNNLFVFDKKGKFVRQIGAQGNG----PGEYLQINDFIIDKSNNSIYILDFMQNKILTYDLDGYSFIGEI 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908  726 KHASFgrNVFAISYIPGFLFAVNGKPYFGDQEPVQgFVMNFSSGEIIDVFKPVRKHFDM---PHDIVASEDGTVYIGDAH 802
Cdd:pfam17170 129 NLDLL--PSDCCQLDKGKLAFDSSGFDDGKRSGFY-LVITDELGNIISGFFPAEFTLGIlfnSSVPFYEYGDNIYFYPYY 205

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 755493908  803 TNTVWKftLTESRLEVEHrSVKKAGIEVPEIkadhdRKLESSSGR 847
Cdd:pfam17170 206 SPTVYK--IMDGELKPAY-EFDFGGKKNPSI-----DFLKKIETK 242
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 584-661 8.57e-05

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 45.28  E-value: 8.57e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755493908 584 PHGLSIDTDGNYWVTDVALHQVFKLEPRSkeGPLLVLgrsmqPGSDQNHfcqPTDVAVEPStGAVFVSDGYcNSRIVQ 661
Cdd:cd14952   96 PTGVAVDAAGNVYVADTGNNRVLKLAAGS--NTQTVL-----PFTGLSN---PDGVAVDGA-GNVYVTDTG-NNRVLK 161
NHL_TRIM32_like cd14961
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ...
 627-720 8.63e-05

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271331 [Multi-domain]  Cd Length: 273  Bit Score: 45.34  E-value: 8.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 627 GSDQNHFCQPTDVAVEPsTGAVFVSD-GycNSRIVQFSPSGKFITQWGEESSGSSPKP---------------------- 683
Cdd:cd14961    4 GGWPGTLNNPTGVAVTP-TGRVVVADdG--NKRIQVFDSDGNCLQQFGPKGDAGQDIRypldvavtpdghivvtdagdrs 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 755493908 684 ---------------GQFSVPHSLALVPHlNQLCVADRENGRIQCFKTDTKE 720
Cdd:cd14961   81 vkvfsfdgrlklfvrKSFSLPWGVAVNPS-GEILVTDSEAGKLFVLTVDFKL 131
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 574-663 2.54e-04

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 43.79  E-value: 2.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 574 QSSGKNLFYLPHGLSIDTDGNYWVTDVALH--QVFkleprSKEGpllVLGRSM-QPGSDQNHFCQPTDVAVEpSTGAVFV 650
Cdd:cd14957  198 SGSGPGQFSDPYGIAVDSDGNIYVADTGNHriQVF-----TSSG---AYQYSIgTSGSGNGQFNYPYGIAVD-NDGKIYV 268

                         90
                 ....*....|...
gi 755493908 651 SDGYcNSRIVQFS 663
Cdd:cd14957  269 ADSN-NNRIQVFN 280
MALA cd12811
Mala s 1 allergenic protein and similar proteins; This family includes the yeast Malassezia ...
 636-741 4.81e-04

Mala s 1 allergenic protein and similar proteins; This family includes the yeast Malassezia sympodialis allergen Mala s 1 which is localized in the cell wall and exposed on the cell surface. It can elicit specific IgE and T-cell activity in patients with atopic eczema (AE), a chronic inflammatory disease. Mala s 1 does not show any significant sequence homology to characterized proteins. However, its structure is a beta-propeller which is a novel fold among allergens.


Pssm-ID: 411995 [Multi-domain]  Cd Length: 304  Bit Score: 43.39  E-value: 4.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 636 PTDVAVEPStGAVFVSDGYCNSrIVQFSPSGKFITQWGEESSGSSPKPGqFSvphSLALVPHLNQLCVADRENGRIQCFK 715
Cdd:cd12811  123 FQDSAQDSD-GNSYVVGALPPA-IAKVSPDGKTVTPWFLEAPNGSTRPG-YT---GIAYIPEDNVLLASGGEPGQLTRFD 196

                         90       100       110
                 ....*....|....*....|....*....|
gi 755493908 716 TD----TKEFVReIKHASFGRNVFAIsYIP 741
Cdd:cd12811  197 LSsatpTPIPVK-ISGENFGGLDDGE-KLP 224
NHL pfam01436
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is ...
 686-714 8.95e-04

NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is about 40 residues long and resembles the WD repeat pfam00400. The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats.


Pssm-ID: 396153 [Multi-domain]  Cd Length: 28  Bit Score: 37.38  E-value: 8.95e-04
                          10        20
                  ....*....|....*....|....*....
gi 755493908  686 FSVPHSLALVPhLNQLCVADRENGRIQCF 714
Cdd:pfam01436   1 FNRPHGVAVDS-NGDIYVADSENHRVQVF 28
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 584-664 2.01e-03

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 41.04  E-value: 2.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 584 PHGLSIDTDGNYWVTDVALHQVFKLEPRSKEGPLLvlgrsmqPGSDQNHfcqPTDVAVEpSTGAVFVSDgYCNSRIVQFS 663
Cdd:cd14952  138 PDGVAVDGAGNVYVTDTGNNRVLKLAAGSTTQTVL-------PFTGLNS---PSGVAVD-TAGNVYVTD-HGNNRVLKLA 205


                 .
gi 755493908 664 P 664
Cdd:cd14952  206 A 206
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
558-657 3.91e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 40.06  E-value: 3.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755493908 558 EEDTILVIDPNKAEILQS--SGKNlfylPHGLSIDTDGNY-WVTDVALHQ----VFKLEPRSKEgpllVLGRsMQPGSdq 630
Cdd:COG3391  130 GNGRVSVIDTATGKVVATipVGAG----PHGIAVDPDGKRlYVANSGSNTvsviVSVIDTATGK----VVAT-IPVGG-- 198

                         90       100
                 ....*....|....*....|....*..
gi 755493908 631 nhfcQPTDVAVEPSTGAVFVSDGYCNS 657
Cdd:COG3391  199 ----GPVGVAVSPDGRRLYVANRGSNT 221
NHL pfam01436
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is ...
 782-809 4.07e-03

NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is about 40 residues long and resembles the WD repeat pfam00400. The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats.


Pssm-ID: 396153 [Multi-domain]  Cd Length: 28  Bit Score: 35.46  E-value: 4.07e-03
                          10        20
                  ....*....|....*....|....*...
gi 755493908  782 FDMPHDIVASEDGTVYIGDAHTNTVWKF 809
Cdd:pfam01436   1 FNRPHGVAVDSNGDIYVADSENHRVQVF 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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