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Conserved domains on  [gi|767910527|ref|XP_011508320|]
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TRAF3-interacting JNK-activating modulator isoform X4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CC1_T3JAM cd21912
first coiled-coil (CC1) domain found in TRAF3-interacting JNK-activating modulator; ...
 189-233 2.43e-15

first coiled-coil (CC1) domain found in TRAF3-interacting JNK-activating modulator; TRAF3-interacting JNK-activating modulator (T3JAM), also called TRAF3-interacting protein 3 (TRAF3IP3), is a novel protein that specifically interacts with TRAF3 and promotes the activation of JNK. It may function as an adapter molecule that regulates TRAF3-mediated JNK activation. The model corresponds to a conserved region that shows high sequence similarity with the first CC (CC1) domain of Sarcolemmal membrane-associated protein (SLMAP), which is responsible for the binding of suppressor of IKBKE 1 (SIKE1).


:

Pssm-ID: 409288 [Multi-domain]  Cd Length: 45  Bit Score: 69.68  E-value: 2.43e-15
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 767910527 189 VLDKEIIQLSDYLKEALQRELVLKQKMVILQDLLSTLIQASDSSW 233
Cdd:cd21912    1 VLEKEILQLSDYLQEALHRERALKKKLAALQELLSTLLQASEKSW 45
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 242-419 6.54e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 55.06  E-value: 6.54e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910527   242 LKGKLRSLENQLyTCTQKYspwgmkkvllemEDQKNSYEQKAKESLQKVLEEkmnAEQQLQSTQRSLALAEQKCEEWRSQ 321
Cdd:TIGR02168  198 LERQLKSLERQA-EKAERY------------KELKAELRELELALLVLRLEE---LREELEELQEELKEAEEELEELTAE 261

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910527   322 YEALKEDWRTLGTQHRELESQLHVLQSKLQGADSRDLQMNQALRFLENEHQQLQAKIECLQGDRDLCSLDTQDLQDQLKR 401
Cdd:TIGR02168  262 LQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAE 341

                          170
                   ....*....|....*...
gi 767910527   402 SEAEKLTLVTRVQQLQEA 419
Cdd:TIGR02168  342 LEEKLEELKEELESLEAE 359
 
Name Accession Description Interval E-value
CC1_T3JAM cd21912
first coiled-coil (CC1) domain found in TRAF3-interacting JNK-activating modulator; ...
 189-233 2.43e-15

first coiled-coil (CC1) domain found in TRAF3-interacting JNK-activating modulator; TRAF3-interacting JNK-activating modulator (T3JAM), also called TRAF3-interacting protein 3 (TRAF3IP3), is a novel protein that specifically interacts with TRAF3 and promotes the activation of JNK. It may function as an adapter molecule that regulates TRAF3-mediated JNK activation. The model corresponds to a conserved region that shows high sequence similarity with the first CC (CC1) domain of Sarcolemmal membrane-associated protein (SLMAP), which is responsible for the binding of suppressor of IKBKE 1 (SIKE1).


Pssm-ID: 409288 [Multi-domain]  Cd Length: 45  Bit Score: 69.68  E-value: 2.43e-15
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 767910527 189 VLDKEIIQLSDYLKEALQRELVLKQKMVILQDLLSTLIQASDSSW 233
Cdd:cd21912    1 VLEKEILQLSDYLQEALHRERALKKKLAALQELLSTLLQASEKSW 45
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 242-419 6.54e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 55.06  E-value: 6.54e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910527   242 LKGKLRSLENQLyTCTQKYspwgmkkvllemEDQKNSYEQKAKESLQKVLEEkmnAEQQLQSTQRSLALAEQKCEEWRSQ 321
Cdd:TIGR02168  198 LERQLKSLERQA-EKAERY------------KELKAELRELELALLVLRLEE---LREELEELQEELKEAEEELEELTAE 261

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910527   322 YEALKEDWRTLGTQHRELESQLHVLQSKLQGADSRDLQMNQALRFLENEHQQLQAKIECLQGDRDLCSLDTQDLQDQLKR 401
Cdd:TIGR02168  262 LQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAE 341

                          170
                   ....*....|....*...
gi 767910527   402 SEAEKLTLVTRVQQLQEA 419
Cdd:TIGR02168  342 LEEKLEELKEELESLEAE 359
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 241-420 3.49e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 52.63  E-value: 3.49e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910527 241 KLKGKLRSLENQLYtctqkyspwgmkkvLLEMEDQKNSYEQKAKEsLQKVLEEKMNAEQQLQSTQRSLALAEQKCEEWRS 320
Cdd:COG1196  217 ELKEELKELEAELL--------------LLKLRELEAELEELEAE-LEELEAELEELEAELAELEAELEELRLELEELEL 281

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910527 321 QYEALKEDWRTLGTQHRELESQLHVLQSKLQGADSRDLQMNQALRFLENEHQQLQAKIECLQGDRDLCSLDTQDLQDQLK 400
Cdd:COG1196  282 ELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELA 361

                        170       180
                 ....*....|....*....|
gi 767910527 401 RSEAEKLTLVTRVQQLQEAA 420
Cdd:COG1196  362 EAEEALLEAEAELAEAEEEL 381
FPP pfam05911
Filament-like plant protein, long coiled-coil; FPP is a family of long coiled-coil plant ...
 274-407 8.31e-04

Filament-like plant protein, long coiled-coil; FPP is a family of long coiled-coil plant proteins that are filament-like. It interacts with the nuclear envelope-associated protein, MAF1, the WPP family pfam13943.


Pssm-ID: 461778 [Multi-domain]  Cd Length: 859  Bit Score: 41.58  E-value: 8.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910527  274 DQKNSYEQKAKESLQKVLEEKMNAE-------QQLQSTQRSLALAEQKCEEWRSQYEALK--------------EDWRTL 332
Cdd:pfam05911 677 DLKTEENKRLKEEFEQLKSEKENLEvelasctENLESTKSQLQESEQLIAELRSELASLKesnslaetqlkcmaESYEDL 756

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767910527  333 GTQHRELESQLHVLQSKLQGadsrdlqmnqalrfLENEhqqLQAKIECLQGDRDLCsldtQDLQDQLKRSEAEKL 407
Cdd:pfam05911 757 ETRLTELEAELNELRQKFEA--------------LEVE---LEEEKNCHEELEAKC----LELQEQLERNEKKES 810
 
Name Accession Description Interval E-value
CC1_T3JAM cd21912
first coiled-coil (CC1) domain found in TRAF3-interacting JNK-activating modulator; ...
 189-233 2.43e-15

first coiled-coil (CC1) domain found in TRAF3-interacting JNK-activating modulator; TRAF3-interacting JNK-activating modulator (T3JAM), also called TRAF3-interacting protein 3 (TRAF3IP3), is a novel protein that specifically interacts with TRAF3 and promotes the activation of JNK. It may function as an adapter molecule that regulates TRAF3-mediated JNK activation. The model corresponds to a conserved region that shows high sequence similarity with the first CC (CC1) domain of Sarcolemmal membrane-associated protein (SLMAP), which is responsible for the binding of suppressor of IKBKE 1 (SIKE1).


Pssm-ID: 409288 [Multi-domain]  Cd Length: 45  Bit Score: 69.68  E-value: 2.43e-15
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 767910527 189 VLDKEIIQLSDYLKEALQRELVLKQKMVILQDLLSTLIQASDSSW 233
Cdd:cd21912    1 VLEKEILQLSDYLQEALHRERALKKKLAALQELLSTLLQASEKSW 45
CC1_SLMAP cd21911
first coiled-coil (CC1) domain found in Sarcolemmal membrane-associated protein; Sarcolemmal ...
 193-253 7.85e-12

first coiled-coil (CC1) domain found in Sarcolemmal membrane-associated protein; Sarcolemmal membrane-associated protein (SLMAP), also called Sarcolemmal membrane-associated protein, is a cardiac tail-anchored membrane protein that may play a role during myoblast fusion. SLMAP contains an N-terminal FHA domain followed by four coiled-coil (CC) domains and a transmembrane domain. The model corresponds to the first CC (CC1) domain that is responsible for the binding of suppressor of IKBKE 1 (SIKE1).


Pssm-ID: 409287 [Multi-domain]  Cd Length: 63  Bit Score: 60.01  E-value: 7.85e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767910527 193 EIIQLSDYLKEALQRELVLKQKMVILQDLLSTLIQASDSSWKGQLNEDKLKGKLRSLENQL 253
Cdd:cd21911    2 ELFQLQQYLQEALHREQILEQKLETLQRLLSSTQEASESSWQALIDEDRLLSRLELLENQL 62
CC1_SLMAP-like cd21868
first coiled-coil (CC1) domain found in Sarcolemmal membrane-associated protein and similar ...
 196-233 6.05e-10

first coiled-coil (CC1) domain found in Sarcolemmal membrane-associated protein and similar proteins; The family includes Sarcolemmal membrane-associated protein (SLMAP), its paralog TRAF3-interacting JNK-activating modulator (T3JAM), and similar proteins. SLMAP, also called Sarcolemmal membrane-associated protein, is a cardiac tail-anchored membrane protein that may play a role during myoblast fusion. T3JAM, also called TRAF3-interacting protein 3 (TRAF3IP3), is a novel protein that specifically interacts with TRAF3 and promotes the activation of JNK. It may function as an adapter molecule that regulates TRAF3-mediated JNK activation. SLMAP contains an N-terminal FHA domain, followed by four coiled-coil (CC) domains and a transmembrane domain. The model corresponds to the first CC (CC1) domain that is responsible for the binding of suppressor of IKBKE 1 (SIKE1).


Pssm-ID: 409286 [Multi-domain]  Cd Length: 38  Bit Score: 54.03  E-value: 6.05e-10
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 767910527 196 QLSDYLKEALQRELVLKQKMVILQDLLSTLIQASDSSW 233
Cdd:cd21868    1 QLNQYIQEALQREQSLENKLANLQEILEATKKAAEESW 38
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 242-419 6.54e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 55.06  E-value: 6.54e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910527   242 LKGKLRSLENQLyTCTQKYspwgmkkvllemEDQKNSYEQKAKESLQKVLEEkmnAEQQLQSTQRSLALAEQKCEEWRSQ 321
Cdd:TIGR02168  198 LERQLKSLERQA-EKAERY------------KELKAELRELELALLVLRLEE---LREELEELQEELKEAEEELEELTAE 261

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910527   322 YEALKEDWRTLGTQHRELESQLHVLQSKLQGADSRDLQMNQALRFLENEHQQLQAKIECLQGDRDLCSLDTQDLQDQLKR 401
Cdd:TIGR02168  262 LQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAE 341

                          170
                   ....*....|....*...
gi 767910527   402 SEAEKLTLVTRVQQLQEA 419
Cdd:TIGR02168  342 LEEKLEELKEELESLEAE 359
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 241-420 3.49e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 52.63  E-value: 3.49e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910527 241 KLKGKLRSLENQLYtctqkyspwgmkkvLLEMEDQKNSYEQKAKEsLQKVLEEKMNAEQQLQSTQRSLALAEQKCEEWRS 320
Cdd:COG1196  217 ELKEELKELEAELL--------------LLKLRELEAELEELEAE-LEELEAELEELEAELAELEAELEELRLELEELEL 281

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910527 321 QYEALKEDWRTLGTQHRELESQLHVLQSKLQGADSRDLQMNQALRFLENEHQQLQAKIECLQGDRDLCSLDTQDLQDQLK 400
Cdd:COG1196  282 ELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELA 361

                        170       180
                 ....*....|....*....|
gi 767910527 401 RSEAEKLTLVTRVQQLQEAA 420
Cdd:COG1196  362 EAEEALLEAEAELAEAEEEL 381
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 296-420 6.99e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 48.51  E-value: 6.99e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910527   296 NAEQQLQSTQRSLALAEQKCEEWRSQYEALKEDWRTLGTQHRELESQLHVLQSKLQGADSRDLQMNQALRFLENEHQQLQ 375
Cdd:TIGR02168  667 KTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLE 746

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 767910527   376 AKIECLQGD-------RDLCSLDTQDLQDQLKRSEAEKLTLVTRVQQLQEAA 420
Cdd:TIGR02168  747 ERIAQLSKElteleaeIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEEL 798
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
260-418 8.41e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 44.76  E-value: 8.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910527 260 YSPWGMKKVLLEMEDQKNSYEQKAKESLQKVLEEKMNAEQQLQSTQRSLALAEQKCEEWRSQYEALKEDWRTLGTQhREL 339
Cdd:COG4717   59 FKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYQEL-EAL 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910527 340 ESQLHVLQSKLQGADSRDLQMNQA---LRFLENEHQQLQAKIECLQGDRDLCSLDT-QDLQDQLKRSEAEKLTLVTRVQQ 415
Cdd:COG4717  138 EAELAELPERLEELEERLEELRELeeeLEELEAELAELQEELEELLEQLSLATEEElQDLAEELEELQQRLAELEEELEE 217


                 ...
gi 767910527 416 LQE 418
Cdd:COG4717  218 AQE 220
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
235-419 3.94e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.98  E-value: 3.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910527  235 GQLNEDKLKGK---LRSLENQLYTCTQKYSpwGMKKVLLEMEDQKNSYEQKAK--------ESLQKVLEEKMNAEQQLQS 303
Cdd:COG4913   605 GFDNRAKLAALeaeLAELEEELAEAEERLE--ALEAELDALQERREALQRLAEyswdeidvASAEREIAELEAELERLDA 682

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910527  304 TQRSLALAEQKCEEWRSQYEALKEDWRTLGTQHRELESQLHVLQSKLQGADSRDLQMNQALRflENEHQQLQAKIECLQG 383
Cdd:COG4913   683 SSDDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLAR--LELRALLEERFAAALG 760

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 767910527  384 DRDLCSLdTQDLQDQLKRSEAEKLTLVTRVQQLQEA 419
Cdd:COG4913   761 DAVEREL-RENLEERIDALRARLNRAEEELERAMRA 795
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
311-421 3.98e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.98  E-value: 3.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910527  311 AEQKCEEWRSQYEALKEDWRTLGTQHRELESQLHVLQSKLqgadsRDLQMNQALRFLENEHQQLQAKIECLQGDRDLCSL 390
Cdd:COG4913   608 NRAKLAALEAELAELEEELAEAEERLEALEAELDALQERR-----EALQRLAEYSWDEIDVASAEREIAELEAELERLDA 682

                          90       100       110
                  ....*....|....*....|....*....|....
gi 767910527  391 DTQD---LQDQLKRSEAEKLTLVTRVQQLQEAAG 421
Cdd:COG4913   683 SSDDlaaLEEQLEELEAELEELEEELDELKGEIG 716
FPP pfam05911
Filament-like plant protein, long coiled-coil; FPP is a family of long coiled-coil plant ...
 274-407 8.31e-04

Filament-like plant protein, long coiled-coil; FPP is a family of long coiled-coil plant proteins that are filament-like. It interacts with the nuclear envelope-associated protein, MAF1, the WPP family pfam13943.


Pssm-ID: 461778 [Multi-domain]  Cd Length: 859  Bit Score: 41.58  E-value: 8.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910527  274 DQKNSYEQKAKESLQKVLEEKMNAE-------QQLQSTQRSLALAEQKCEEWRSQYEALK--------------EDWRTL 332
Cdd:pfam05911 677 DLKTEENKRLKEEFEQLKSEKENLEvelasctENLESTKSQLQESEQLIAELRSELASLKesnslaetqlkcmaESYEDL 756

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767910527  333 GTQHRELESQLHVLQSKLQGadsrdlqmnqalrfLENEhqqLQAKIECLQGDRDLCsldtQDLQDQLKRSEAEKL 407
Cdd:pfam05911 757 ETRLTELEAELNELRQKFEA--------------LEVE---LEEEKNCHEELEAKC----LELQEQLERNEKKES 810
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 204-420 1.60e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 40.69  E-value: 1.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910527 204 ALQRELVLKQKMVILQDLLSTLIQASDSswkgQLNEDKLKGKLRSLENQLYTCTQKYSpwGMKKVLLEMEDQKNSY---E 280
Cdd:COG1196  217 ELKEELKELEAELLLLKLRELEAELEEL----EAELEELEAELEELEAELAELEAELE--ELRLELEELELELEEAqaeE 290

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910527 281 QKAKESLQKVLEEKMNAEQQLQSTQRSLALAEQKCEEWRSQYEALKEDWRTLGTQHRELESQLHVLQSKLQGADSRDLQM 360
Cdd:COG1196  291 YELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEA 370

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910527 361 NQALRFLENEHQQLQAKIECLQGDRDLCSLDTQDLQDQLKRSEAEKLTLVTRVQQLQEAA 420
Cdd:COG1196  371 EAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEAL 430
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 188-378 1.62e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 40.81  E-value: 1.62e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910527   188 AVLDKEIIQLSDYLKEALQRELVLKQKMVILQDLLSTLIQASDSSwKGQLNEdkLKGKLRSLENQLYTCTQKYSPWGMKK 267
Cdd:TIGR02168  764 EELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDEL-RAELTL--LNEEAANLRERLESLERRIAATERRL 840

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910527   268 VLLEMEDQKNSYEQKAKESLQKVLEEKMN-AEQQLQSTQRSLALAEQKCEEWRSQYEALKEDWRTLGTQHRELESQLHVL 346
Cdd:TIGR02168  841 EDLEEQIEELSEDIESLAAEIEELEELIEeLESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEEL 920

                          170       180       190
                   ....*....|....*....|....*....|..
gi 767910527   347 QSKLQgadsrdlQMNQALRFLENEHQQLQAKI 378
Cdd:TIGR02168  921 REKLA-------QLELRLEGLEVRIDNLQERL 945
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 272-418 3.77e-03

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 39.77  E-value: 3.77e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910527   272 MEDQKNSYEQKAKESLQKVLEEKMNAEQQLQSTQRSLALAEQKCEEWRSQYEALKEDWRTLGT-------QHRELESQLH 344
Cdd:pfam01576  336 LEEETRSHEAQLQEMRQKHTQALEELTEQLEQAKRNKANLEKAKQALESENAELQAELRTLQQakqdsehKRKKLEGQLQ 415

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910527   345 VLQSKLQGADSRDLQMNQALRFLENEHQQL-----QAKIECLQGDRDLCSLDT--QDLQDQLKRSEAEKLTLVTRVQQLQ 417
Cdd:pfam01576  416 ELQARLSESERQRAELAEKLSKLQSELESVssllnEAEGKNIKLSKDVSSLESqlQDTQELLQEETRQKLNLSTRLRQLE 495


                   .
gi 767910527   418 E 418
Cdd:pfam01576  496 D 496
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 174-418 3.86e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 39.62  E-value: 3.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910527  174 TIKNDASQQTNYGVAVLDKEIIQLSDYLKEALQRELVLKQKMVILQDL---LSTLIQASDSSWKGQLNED--KLKGKLRS 248
Cdd:TIGR04523 246 TEISNTQTQLNQLKDEQNKIKKQLSEKQKELEQNNKKIKELEKQLNQLkseISDLNNQKEQDWNKELKSElkNQEKKLEE 325

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910527  249 LENQLYTCTQKYSPWGMKKVLLEME---------------DQKNSYEQKAKESLQKVLEEKMNAEQQLQSTQRSLALAEQ 313
Cdd:TIGR04523 326 IQNQISQNNKIISQLNEQISQLKKEltnsesensekqrelEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEK 405

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910527  314 KCEEWRSQYEALKEDWRTLGTQHRELESQLHVLQSKLQGADSRDLQMNQALRFLENEHQQLQAKIECLQGDRDLCSLDTQ 393
Cdd:TIGR04523 406 LNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLE 485

                         250       260
                  ....*....|....*....|....*
gi 767910527  394 DLQDQLKRSEAEKLTLVTRVQQLQE 418
Cdd:TIGR04523 486 QKQKELKSKEKELKKLNEEKKELEE 510
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 201-420 5.19e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 39.27  E-value: 5.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910527   201 LKEALQRELVLKQKMVILQDLLSTLIQASDSSWkgqlneDKLKGKLRSLENQLYTCTQKYspWGMKKVLLEMEDQKnsye 280
Cdd:TIGR02168  237 LREELEELQEELKEAEEELEELTAELQELEEKL------EELRLEVSELEEEIEELQKEL--YALANEISRLEQQK---- 304

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910527   281 QKAKESLQKVLEEKMNAEQQLQSTQRSLALAEQKCEEWRSQYEALKEDWRTLGTQHRELESQLHVLQSKLQGADSRDLQM 360
Cdd:TIGR02168  305 QILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETL 384

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767910527   361 NQALRFLENEHQQLQAKIECL-------------------QGDRDLCSLDTQDLQDQLKRSEAEKLTLVTRVQQLQEAA 420
Cdd:TIGR02168  385 RSKVAQLELQIASLNNEIERLearlerledrrerlqqeieELLKKLEEAELKELQAELEELEEELEELQEELERLEEAL 463
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 190-386 5.70e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 39.27  E-value: 5.70e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910527   190 LDKEIIQLSDYLKEALQRELVLKQKMVILQDLLSTLiQASDSSWKGQLNEdkLKGKLRSLENQLYTCTQkyspwgmkkvl 269
Cdd:TIGR02168  314 LERQLEELEAQLEELESKLDELAEELAELEEKLEEL-KEELESLEAELEE--LEAELEELESRLEELEE----------- 379

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910527   270 lEMEDQKNSYEQkAKESLQKVLEEKMNAEQQLQSTQRSLALAEQKCEEWRSQYE--ALKEDWRTLGTQHRELE---SQLH 344
Cdd:TIGR02168  380 -QLETLRSKVAQ-LELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEeaELKELQAELEELEEELEelqEELE 457

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 767910527   345 VLQSKLQGADSRDLQMNQALRFLENEHQQLQAKIECLQGDRD 386
Cdd:TIGR02168  458 RLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQE 499
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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