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Conserved domains on  [gi|767926595|ref|XP_011511072|]
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probable cation-transporting ATPase 13A5 isoform X1 [Homo sapiens]

Protein Classification

cation-transporting P-type ATPase( domain architecture ID 12116058)

cation-transporting P-type ATPase is an integral membrane transporter that generates and maintains electrochemical gradients across cellular membranes by translocating cations, and is distinguished from other transport ATPases (F-, V-, and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
HAD_like super family cl21460
Haloacid Dehalogenase-like Hydrolases; The haloacid dehalogenase (HAD) superfamily includes ...
174-949 0e+00

Haloacid Dehalogenase-like Hydrolases; The haloacid dehalogenase (HAD) superfamily includes carbon and phosphorus hydrolases such as 2-haloalkonoate dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, among others. These proteins catalyze nucleophilic substitution reactions at phosphorus or carbon centers, using a conserved Asp carboxylate in covalent catalysis. All members possess a conserve alpha/beta core domain, and many also possess a small cap domain, with varying folds and functions.


The actual alignment was detected with superfamily member cd07542:

Pssm-ID: 473868 [Multi-domain]  Cd Length: 760  Bit Score: 1027.96  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 174 EEQEVRRLVCGPNAIEVEIQPIWKLLVKQVLNPFYVFQAFTLTLWLSQGYIEYSVAIIILTVISIVLSVYDLRQQSVKLH 253
Cdd:cd07542    1 DEQSDRRLIYGPNEIDVPLKSILKLLFKEVLNPFYVFQLFSVILWSSDDYYYYAACIVIISVISIFLSLYETRKQSKRLR 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 254 NLVEDHNKVQVtiiVKDKGLEELESRLLVPGDILILPG-KFSLPCDAVLIDGSCVVNEGMLTGESIPVTKTPLPQMENTM 332
Cdd:cd07542   81 EMVHFTCPVRV---IRDGEWQTISSSELVPGDILVIPDnGTLLPCDAILLSGSCIVNESMLTGESVPVTKTPLPDESNDS 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 333 PWKCHSLEDYRKHVLFCGTEVIQVKPSGQGPVRAVVLQTGYNTAKGDLVRSILYPRPLNFKLYSDAFKFIVFLACLGVMG 412
Cdd:cd07542  158 LWSIYSIEDHSKHTLFCGTKVIQTRAYEGKPVLAVVVRTGFNTTKGQLVRSILYPKPVDFKFYRDSMKFILFLAIIALIG 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 413 FFYALGVYMYHGVPPKDTVTMALILLTVTVPPVLPAALTIGNVYAQKRLKKKKIFCISPQRINMCGQINLVCFDKTGTLT 492
Cdd:cd07542  238 FIYTLIILILNGESLGEIIIRALDIITIVVPPALPAALTVGIIYAQSRLKKKGIFCISPQRINICGKINLVCFDKTGTLT 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 493 EDGLDLWGTVPTADNCFQEAHSFASGQAV----PWSPLCAAMASCHSLILLNGTIQGDPLDLKMFEGTAWKMEdcivdsc 568
Cdd:cd07542  318 EDGLDLWGVRPVSGNNFGDLEVFSLDLDLdsslPNGPLLRAMATCHSLTLIDGELVGDPLDLKMFEFTGWSLE------- 390
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 569 kfgtsvsnIIKpgpkaskspveaiitlcQFPFSSSLQRMSVIAQLAGENHFHVYMKGAPEMVARFCRSETVPKNFPQELR 648
Cdd:cd07542  391 --------ILR-----------------QFPFSSALQRMSVIVKTPGDDSMMAFTKGAPEMIASLCKPETVPSNFQEVLN 445
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 649 SYTVQGFRVIALAHKTLKMgNLSEVEHLAREKVESELTFLGLLIMENRLKKETKLVLKELSEARIRTVMITGDNLQTAIT 728
Cdd:cd07542  446 EYTKQGFRVIALAYKALES-KTWLLQKLSREEVESDLEFLGLIVMENRLKPETAPVINELNRANIRTVMVTGDNLLTAIS 524
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 729 VAKNSEMIPPGSQVIIVEADEPEEFVPASVTWqlvenqetgpgkkeiymhtgnsstprgeggscyhfamsgksyqvifqh 808
Cdd:cd07542  525 VARECGMISPSKKVILIEAVKPEDDDSASLTW------------------------------------------------ 556
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 809 fnsllpKILVNGTVFARMSPGQKSSLIEEFQKLNYYVGMCGDGANDCGALKAAHAGISLSEQEASVASPFTSKTTNIQCV 888
Cdd:cd07542  557 ------TLLLKGTVFARMSPDQKSELVEELQKLDYTVGMCGDGANDCGALKAADVGISLSEAEASVAAPFTSKVPDISCV 630
                        730       740       750       760       770       780
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767926595 889 PHLIREGRAALVSSFGVFKYLTMYGIIQFISALLLYWQLQLFGNYQYLMQDVAITLMVCLT 949
Cdd:cd07542  631 PTVIKEGRAALVTSFSCFKYMALYSLIQFISVLILYSINSNLGDFQFLFIDLVIITPIAVF 691
P5-ATPase pfam12409
P5-type ATPase cation transporter; This domain family is found in eukaryotes, and is typically ...
17-142 2.46e-35

P5-type ATPase cation transporter; This domain family is found in eukaryotes, and is typically between 110 and 126 amino acids in length. The family is found in association with pfam00122, pfam00702. P-type ATPases comprise a large superfamily of proteins, present in both prokaryotes and eukaryotes, that transport inorganic cations and other substrates across cell membranes.


:

Pssm-ID: 463565  Cd Length: 123  Bit Score: 130.36  E-value: 2.46e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595   17 EEDELEVFGYRDHNVRKAFCLVASVLTCGGLLLVFYWRPQWRVWANCIPCPLQEADTVLLRttDEFQRYMRKKVFCLY-- 94
Cdd:pfam12409   1 EDLTIEIAGYRTSRWRLALYLLLCVLTLGLLYLLFRWLPRWRVRLTGKPCPLAEADWVVIE--DEFGELSIKKVKKLPyg 78
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 767926595   95 --LSTLKFPvsKKWEESLVADRHSVINQALIKpelKLRCMEVQKIRYVWN 142
Cdd:pfam12409  79 rpLSTVFPL--LVGESSSVISKADEDNDPELP---QLRYFDYRYIRYIWH 123
 
Name Accession Description Interval E-value
P-type_ATPase_cation cd07542
P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and ...
174-949 0e+00

P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and Saccharomyces cerevisiae Ypk9p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. This subfamily also includes zebrafish ATP13A2 a lysosome-specific transmembrane ATPase protein of unknown function which plays a crucial role during embryonic development, its deletion is lethal. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319842 [Multi-domain]  Cd Length: 760  Bit Score: 1027.96  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 174 EEQEVRRLVCGPNAIEVEIQPIWKLLVKQVLNPFYVFQAFTLTLWLSQGYIEYSVAIIILTVISIVLSVYDLRQQSVKLH 253
Cdd:cd07542    1 DEQSDRRLIYGPNEIDVPLKSILKLLFKEVLNPFYVFQLFSVILWSSDDYYYYAACIVIISVISIFLSLYETRKQSKRLR 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 254 NLVEDHNKVQVtiiVKDKGLEELESRLLVPGDILILPG-KFSLPCDAVLIDGSCVVNEGMLTGESIPVTKTPLPQMENTM 332
Cdd:cd07542   81 EMVHFTCPVRV---IRDGEWQTISSSELVPGDILVIPDnGTLLPCDAILLSGSCIVNESMLTGESVPVTKTPLPDESNDS 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 333 PWKCHSLEDYRKHVLFCGTEVIQVKPSGQGPVRAVVLQTGYNTAKGDLVRSILYPRPLNFKLYSDAFKFIVFLACLGVMG 412
Cdd:cd07542  158 LWSIYSIEDHSKHTLFCGTKVIQTRAYEGKPVLAVVVRTGFNTTKGQLVRSILYPKPVDFKFYRDSMKFILFLAIIALIG 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 413 FFYALGVYMYHGVPPKDTVTMALILLTVTVPPVLPAALTIGNVYAQKRLKKKKIFCISPQRINMCGQINLVCFDKTGTLT 492
Cdd:cd07542  238 FIYTLIILILNGESLGEIIIRALDIITIVVPPALPAALTVGIIYAQSRLKKKGIFCISPQRINICGKINLVCFDKTGTLT 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 493 EDGLDLWGTVPTADNCFQEAHSFASGQAV----PWSPLCAAMASCHSLILLNGTIQGDPLDLKMFEGTAWKMEdcivdsc 568
Cdd:cd07542  318 EDGLDLWGVRPVSGNNFGDLEVFSLDLDLdsslPNGPLLRAMATCHSLTLIDGELVGDPLDLKMFEFTGWSLE------- 390
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 569 kfgtsvsnIIKpgpkaskspveaiitlcQFPFSSSLQRMSVIAQLAGENHFHVYMKGAPEMVARFCRSETVPKNFPQELR 648
Cdd:cd07542  391 --------ILR-----------------QFPFSSALQRMSVIVKTPGDDSMMAFTKGAPEMIASLCKPETVPSNFQEVLN 445
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 649 SYTVQGFRVIALAHKTLKMgNLSEVEHLAREKVESELTFLGLLIMENRLKKETKLVLKELSEARIRTVMITGDNLQTAIT 728
Cdd:cd07542  446 EYTKQGFRVIALAYKALES-KTWLLQKLSREEVESDLEFLGLIVMENRLKPETAPVINELNRANIRTVMVTGDNLLTAIS 524
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 729 VAKNSEMIPPGSQVIIVEADEPEEFVPASVTWqlvenqetgpgkkeiymhtgnsstprgeggscyhfamsgksyqvifqh 808
Cdd:cd07542  525 VARECGMISPSKKVILIEAVKPEDDDSASLTW------------------------------------------------ 556
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 809 fnsllpKILVNGTVFARMSPGQKSSLIEEFQKLNYYVGMCGDGANDCGALKAAHAGISLSEQEASVASPFTSKTTNIQCV 888
Cdd:cd07542  557 ------TLLLKGTVFARMSPDQKSELVEELQKLDYTVGMCGDGANDCGALKAADVGISLSEAEASVAAPFTSKVPDISCV 630
                        730       740       750       760       770       780
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767926595 889 PHLIREGRAALVSSFGVFKYLTMYGIIQFISALLLYWQLQLFGNYQYLMQDVAITLMVCLT 949
Cdd:cd07542  631 PTVIKEGRAALVTSFSCFKYMALYSLIQFISVLILYSINSNLGDFQFLFIDLVIITPIAVF 691
P-ATPase-V TIGR01657
P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade ...
18-949 0e+00

P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade but the substrate of their pumping activity has yet to be determined. This clade has been designated type V in.


Pssm-ID: 273738 [Multi-domain]  Cd Length: 1054  Bit Score: 888.25  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595    18 EDELEVFGYRDHNVRKAFCLVASVLTCGGLLLVFYWRPQWRVWANCIPCPLQEADTVLLRTTDEFQrymrkkvfclyLST 97
Cdd:TIGR01657    1 DKTIGISAYKISPFKLIIYLVTLILTFGLVLLLLTWLPEWKVKLRYVPVSNEDAETVVIVDPTPNS-----------GSD 69
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595    98 LKFPVSKKWEESLVADRHSVinqaliKPELKLRCMEVQKIRYVWNDLEKRF-----QKVGLLEDSNSCSDIHqtFGLGLT 172
Cdd:TIGR01657   70 YIVELSNKSLSNDLQTENAV------EGGEEPIYFDFRKQRFSYHEKELKIfsplpYLFKEKSFGVYSTCAG--HSNGLT 141
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595   173 SEEQEVRRLVCGPNAIEVEIQPIWKLLVKQVLNPFYVFQAFTLTLWLSQGYIEYSVAIIILTVISIVLSVYDLRQQSVKL 252
Cdd:TIGR01657  142 TGDIAQRKAKYGKNEIEIPVPSFLELLKEEVLHPFYVFQVFSVILWLLDEYYYYSLCIVFMSSTSISLSVYQIRKQMQRL 221
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595   253 HNLVEDHNKVQVtiiVKDKGLEELESRLLVPGDILILP---GKfSLPCDAVLIDGSCVVNEGMLTGESIPVTKTPLPQME 329
Cdd:TIGR01657  222 RDMVHKPQSVIV---IRNGKWVTIASDELVPGDIVSIPrpeEK-TMPCDSVLLSGSCIVNESMLTGESVPVLKFPIPDNG 297
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595   330 nTMPWKCHSLEDYRKHVLFCGTEVIQVKPS-GQGPVRAVVLQTGYNTAKGDLVRSILYPRPLNFKLYSDAFKFIVFLACL 408
Cdd:TIGR01657  298 -DDDEDLFLYETSKKHVLFGGTKILQIRPYpGDTGCLAIVVRTGFSTSKGQLVRSILYPKPRVFKFYKDSFKFILFLAVL 376
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595   409 GVMGFFYALGVYMYHGVPPKDTVTMALILLTVTVPPVLPAALTIGNVYAQKRLKKKKIFCISPQRINMCGQINLVCFDKT 488
Cdd:TIGR01657  377 ALIGFIYTIIELIKDGRPLGKIILRSLDIITIVVPPALPAELSIGINNSLARLKKKGIFCTSPFRINFAGKIDVCCFDKT 456
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595   489 GTLTEDGLDLWGTVPTADNCFQEAHSFASGQAVPwSPLCAAMASCHSLILLNGTIQGDPLDLKMFEGTAWKMEDciVDSC 568
Cdd:TIGR01657  457 GTLTEDGLDLRGVQGLSGNQEFLKIVTEDSSLKP-SITHKALATCHSLTKLEGKLVGDPLDKKMFEATGWTLEE--DDES 533
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595   569 KFGTSVSNIIKPGPKASKSPVeaiitLCQFPFSSSLQRMSVIAQLAGENHFHVYMKGAPEMVARFCRSETVPKNFPQELR 648
Cdd:TIGR01657  534 AEPTSILAVVRTDDPPQELSI-----IRRFQFSSALQRMSVIVSTNDERSPDAFVKGAPETIQSLCSPETVPSDYQEVLK 608
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595   649 SYTVQGFRVIALAHKTLKMGNLSEVEHLAREKVESELTFLGLLIMENRLKKETKLVLKELSEARIRTVMITGDNLQTAIT 728
Cdd:TIGR01657  609 SYTREGYRVLALAYKELPKLTLQKAQDLSRDAVESNLTFLGFIVFENPLKPDTKEVIKELKRASIRTVMITGDNPLTAVH 688
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595   729 VAKNSEMIPPGSQVIIVEADEPEEFVPASVTWQLVENQETGPGKKEI-YMHTGNSSTPRGEggSCYHFAMSGKSYQVIFQ 807
Cdd:TIGR01657  689 VARECGIVNPSNTLILAEAEPPESGKPNQIKFEVIDSIPFASTQVEIpYPLGQDSVEDLLA--SRYHLAMSGKAFAVLQA 766
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595   808 HFNSLLPKILVNGTVFARMSPGQKSSLIEEFQKLNYYVGMCGDGANDCGALKAAHAGISLSEQEASVASPFTSKTTNIQC 887
Cdd:TIGR01657  767 HSPELLLRLLSHTTVFARMAPDQKETLVELLQKLDYTVGMCGDGANDCGALKQADVGISLSEAEASVAAPFTSKLASISC 846
                          890       900       910       920       930       940
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767926595   888 VPHLIREGRAALVSSFGVFKYLTMYGIIQFISALLLYWQLQLFGNYQYLMQDVAITLMVCLT 949
Cdd:TIGR01657  847 VPNVIREGRCALVTSFQMFKYMALYSLIQFYSVSILYLIGSNLGDGQFLTIDLLLIFPVALL 908
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
170-866 1.28e-79

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 277.37  E-value: 1.28e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 170 GLTSEEQEVRRLVCGPNAI-EVEIQPIWKLLVKQVLNPFyvfqafTLTLW-------LSQGYIEySVAIIILTVISIVLS 241
Cdd:COG0474   26 GLSSEEAARRLARYGPNELpEEKKRSLLRRFLEQFKNPL------ILILLaaavisaLLGDWVD-AIVILAVVLLNAIIG 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 242 VY-DLR-QQSV-KLHNLVEDHNKVqvtiiVKDKGLEELESRLLVPGDILIL-PGKFsLPCDAVLIDG-SCVVNEGMLTGE 316
Cdd:COG0474   99 FVqEYRaEKALeALKKLLAPTARV-----LRDGKWVEIPAEELVPGDIVLLeAGDR-VPADLRLLEAkDLQVDESALTGE 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 317 SIPVTKTPLPQMENTmpwkchSLEDyRKHVLFCGTEVIqvkpSGQGpvRAVVLQTGYNTAKG---DLVRSILYPR-PLNF 392
Cdd:COG0474  173 SVPVEKSADPLPEDA------PLGD-RGNMVFMGTLVT----SGRG--TAVVVATGMNTEFGkiaKLLQEAEEEKtPLQK 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 393 KLysDAF-KFIVFLAcLGVMGFFYALGVYmyHGVPPKDTVTMALILLTVTVPPVLPAALTI----GnvyAQKRLKKKKIf 467
Cdd:COG0474  240 QL--DRLgKLLAIIA-LVLAALVFLIGLL--RGGPLLEALLFAVALAVAAIPEGLPAVVTItlalG---AQRMAKRNAI- 310
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 468 cISpqRINMC---GQINLVCFDKTGTLTEDGL---DLWgtvpTADNCFQeahsfASGQAVP-WSPLCAAMASCHSLILLN 540
Cdd:COG0474  311 -VR--RLPAVetlGSVTVICTDKTGTLTQNKMtveRVY----TGGGTYE-----VTGEFDPaLEELLRAAALCSDAQLEE 378
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 541 GTIQGDPldlkmfegtawkMEDCIVDSC-KFGTSVSNIIKPGPKaskspveaiitLCQFPFSSSLQRMSVIAQLAGENHF 619
Cdd:COG0474  379 ETGLGDP------------TEGALLVAAaKAGLDVEELRKEYPR-----------VDEIPFDSERKRMSTVHEDPDGKRL 435
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 620 hVYMKGAPEMVARFCR-----------SETVPKNFPQELRSYTVQGFRVIALAHKTLkmgnlSEVEHLAREKVESELTFL 688
Cdd:COG0474  436 -LIVKGAPEVVLALCTrvltgggvvplTEEDRAEILEAVEELAAQGLRVLAVAYKEL-----PADPELDSEDDESDLTFL 509
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 689 GLLIMENRLKKETKLVLKELSEARIRTVMITGDNLQTAITVAKNSEMIPPGSQVIiveadepeefvpasvtwqlvenqeT 768
Cdd:COG0474  510 GLVGMIDPPRPEAKEAIAECRRAGIRVKMITGDHPATARAIARQLGLGDDGDRVL------------------------T 565
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 769 GpgkKEIymhtgnsstprgeggscyhFAMSGKSyqvifqhfnslLPKILVNGTVFARMSPGQKSSLIEEFQKLNYYVGMC 848
Cdd:COG0474  566 G---AEL-------------------DAMSDEE-----------LAEAVEDVDVFARVSPEHKLRIVKALQANGHVVAMT 612
                        730
                 ....*....|....*...
gi 767926595 849 GDGANDCGALKAAHAGIS 866
Cdd:COG0474  613 GDGVNDAPALKAADIGIA 630
P5-ATPase pfam12409
P5-type ATPase cation transporter; This domain family is found in eukaryotes, and is typically ...
17-142 2.46e-35

P5-type ATPase cation transporter; This domain family is found in eukaryotes, and is typically between 110 and 126 amino acids in length. The family is found in association with pfam00122, pfam00702. P-type ATPases comprise a large superfamily of proteins, present in both prokaryotes and eukaryotes, that transport inorganic cations and other substrates across cell membranes.


Pssm-ID: 463565  Cd Length: 123  Bit Score: 130.36  E-value: 2.46e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595   17 EEDELEVFGYRDHNVRKAFCLVASVLTCGGLLLVFYWRPQWRVWANCIPCPLQEADTVLLRttDEFQRYMRKKVFCLY-- 94
Cdd:pfam12409   1 EDLTIEIAGYRTSRWRLALYLLLCVLTLGLLYLLFRWLPRWRVRLTGKPCPLAEADWVVIE--DEFGELSIKKVKKLPyg 78
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 767926595   95 --LSTLKFPvsKKWEESLVADRHSVINQALIKpelKLRCMEVQKIRYVWN 142
Cdd:pfam12409  79 rpLSTVFPL--LVGESSSVISKADEDNDPELP---QLRYFDYRYIRYIWH 123
E1-E2_ATPase pfam00122
E1-E2 ATPase;
260-464 6.77e-33

E1-E2 ATPase;


Pssm-ID: 425475 [Multi-domain]  Cd Length: 181  Bit Score: 125.38  E-value: 6.77e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595  260 NKVQVtiiVKDKGLEELESRLLVPGDILILPGKFSLPCDAVLIDGSCVVNEGMLTGESIPVTKTplpqmentmpwkchsl 339
Cdd:pfam00122   5 PTATV---LRDGTEEEVPADELVPGDIVLLKPGERVPADGRIVEGSASVDESLLTGESLPVEKK---------------- 65
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595  340 edyRKHVLFCGTEVIqvkpsgQGPVRAVVLQTGYNTAKGDLVRSILYPRPLNFKLYSDAFKFIVFLACLGVMGFFYALGV 419
Cdd:pfam00122  66 ---KGDMVYSGTVVV------SGSAKAVVTATGEDTELGRIARLVEEAKSKKTPLQRLLDRLGKYFSPVVLLIALAVFLL 136
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 767926595  420 YMYHGVPPKDTVTMALILLTVTVPPVLPAALTIGNVYAQKRLKKK 464
Cdd:pfam00122 137 WLFVGGPPLRALLRALAVLVAACPCALPLATPLALAVGARRLAKK 181
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
170-866 4.02e-30

magnesium-transporting P-type ATPase MgtA;


Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 128.65  E-value: 4.02e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 170 GLTSEEQEVRRLVCGPNAIEVEiQPI--WKLLVKQVLNPFYVFqaftLTLWlsqGYIEY-------SVAIIILTVISIVL 240
Cdd:PRK10517  67 GLNEAEVESAREQHGENELPAQ-KPLpwWVHLWVCYRNPFNIL----LTIL---GAISYatedlfaAGVIALMVAISTLL 138
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 241 S-VYDLR--QQSVKLHNLVEdhNKVQVTIIVKDKG---LEELESRLLVPGDILILPGKFSLPCDA-VLIDGSCVVNEGML 313
Cdd:PRK10517 139 NfIQEARstKAADALKAMVS--NTATVLRVINDKGengWLEIPIDQLVPGDIIKLAAGDMIPADLrILQARDLFVAQASL 216
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 314 TGESIPVTKTPLP-QMENTMPWKCHSLedyrkhvLFCGTEVIqvkpsgQGPVRAVVLQTGYNTAKGDLV-RSILYPRPLN 391
Cdd:PRK10517 217 TGESLPVEKFATTrQPEHSNPLECDTL-------CFMGTNVV------SGTAQAVVIATGANTWFGQLAgRVSEQDSEPN 283
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 392 fklysdAFKF---------IVFLAclgVMgffyALGVYMYHGVPPKDTVTMALILLTVTV---PPVLP----AALTIGNV 455
Cdd:PRK10517 284 ------AFQQgisrvswllIRFML---VM----APVVLLINGYTKGDWWEAALFALSVAVgltPEMLPmivtSTLARGAV 350
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 456 YaqkrLKKKKIFCISPQRINMCGQINLVCFDKTGTLTEDGLdlwgtvptadncFQEAHSFASGQAVPWSPLCAAMASCHS 535
Cdd:PRK10517 351 K----LSKQKVIVKRLDAIQNFGAMDILCTDKTGTLTQDKI------------VLENHTDISGKTSERVLHSAWLNSHYQ 414
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 536 LILLN----GTIQGDPLDLKMFEGTAWKMEDCIvdsckfgtsvsniikpgpkaskspveaiitlcqfPFSSSLQRMSVIa 611
Cdd:PRK10517 415 TGLKNlldtAVLEGVDEESARSLASRWQKIDEI----------------------------------PFDFERRRMSVV- 459
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 612 qLAGENHFH-VYMKGAPEMVARFCR-----SETVPKNfPQELR-------SYTVQGFRVIALAHKTLK--MGNLSEVEhl 676
Cdd:PRK10517 460 -VAENTEHHqLICKGALEEILNVCSqvrhnGEIVPLD-DIMLRrikrvtdTLNRQGLRVVAVATKYLParEGDYQRAD-- 535
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 677 arekvESELTFLGLLIMENRLKKETKLVLKELSEARIRTVMITGDNlqtaitvaknsemippgsqviiveadepeEFVPA 756
Cdd:PRK10517 536 -----ESDLILEGYIAFLDPPKETTAPALKALKASGVTVKILTGDS-----------------------------ELVAA 581
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 757 SVTwqlvenQETGPGKKEIYMhtgnsstprgegGScyhfamsgksyqVIFQHFNSLLPKILVNGTVFARMSPGQKSSLIE 836
Cdd:PRK10517 582 KVC------HEVGLDAGEVLI------------GS------------DIETLSDDELANLAERTTLFARLTPMHKERIVT 631
                        730       740       750
                 ....*....|....*....|....*....|
gi 767926595 837 EFQKLNYYVGMCGDGANDCGALKAAHAGIS 866
Cdd:PRK10517 632 LLKREGHVVGFMGDGINDAPALRAADIGIS 661
Cation_ATPase_N smart00831
Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region ...
160-207 1.44e-04

Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region found in several classes of cation-transporting P-type ATPases, including those that transport H+, Na+, Ca2+, Na+/K+, and H+/K+. In the H+/K+- and Na+/K+-exchange P-ATPases, this domain is found in the catalytic alpha chain. In gastric H+/K+-ATPases, this domain undergoes reversible sequential phosphorylation inducing conformational changes that may be important for regulating the function of these ATPases.


Pssm-ID: 214842 [Multi-domain]  Cd Length: 75  Bit Score: 41.03  E-value: 1.44e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 767926595   160 CSDIHQTFGLGLTSEEQEVRRLVCGPNAIEV-EIQPIWKLLVKQVLNPF 207
Cdd:smart00831  13 LERLQTDLEKGLSSEEAARRLERYGPNELPPpKKTSPLLRFLRQFHNPL 61
 
Name Accession Description Interval E-value
P-type_ATPase_cation cd07542
P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and ...
174-949 0e+00

P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and Saccharomyces cerevisiae Ypk9p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. This subfamily also includes zebrafish ATP13A2 a lysosome-specific transmembrane ATPase protein of unknown function which plays a crucial role during embryonic development, its deletion is lethal. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319842 [Multi-domain]  Cd Length: 760  Bit Score: 1027.96  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 174 EEQEVRRLVCGPNAIEVEIQPIWKLLVKQVLNPFYVFQAFTLTLWLSQGYIEYSVAIIILTVISIVLSVYDLRQQSVKLH 253
Cdd:cd07542    1 DEQSDRRLIYGPNEIDVPLKSILKLLFKEVLNPFYVFQLFSVILWSSDDYYYYAACIVIISVISIFLSLYETRKQSKRLR 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 254 NLVEDHNKVQVtiiVKDKGLEELESRLLVPGDILILPG-KFSLPCDAVLIDGSCVVNEGMLTGESIPVTKTPLPQMENTM 332
Cdd:cd07542   81 EMVHFTCPVRV---IRDGEWQTISSSELVPGDILVIPDnGTLLPCDAILLSGSCIVNESMLTGESVPVTKTPLPDESNDS 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 333 PWKCHSLEDYRKHVLFCGTEVIQVKPSGQGPVRAVVLQTGYNTAKGDLVRSILYPRPLNFKLYSDAFKFIVFLACLGVMG 412
Cdd:cd07542  158 LWSIYSIEDHSKHTLFCGTKVIQTRAYEGKPVLAVVVRTGFNTTKGQLVRSILYPKPVDFKFYRDSMKFILFLAIIALIG 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 413 FFYALGVYMYHGVPPKDTVTMALILLTVTVPPVLPAALTIGNVYAQKRLKKKKIFCISPQRINMCGQINLVCFDKTGTLT 492
Cdd:cd07542  238 FIYTLIILILNGESLGEIIIRALDIITIVVPPALPAALTVGIIYAQSRLKKKGIFCISPQRINICGKINLVCFDKTGTLT 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 493 EDGLDLWGTVPTADNCFQEAHSFASGQAV----PWSPLCAAMASCHSLILLNGTIQGDPLDLKMFEGTAWKMEdcivdsc 568
Cdd:cd07542  318 EDGLDLWGVRPVSGNNFGDLEVFSLDLDLdsslPNGPLLRAMATCHSLTLIDGELVGDPLDLKMFEFTGWSLE------- 390
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 569 kfgtsvsnIIKpgpkaskspveaiitlcQFPFSSSLQRMSVIAQLAGENHFHVYMKGAPEMVARFCRSETVPKNFPQELR 648
Cdd:cd07542  391 --------ILR-----------------QFPFSSALQRMSVIVKTPGDDSMMAFTKGAPEMIASLCKPETVPSNFQEVLN 445
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 649 SYTVQGFRVIALAHKTLKMgNLSEVEHLAREKVESELTFLGLLIMENRLKKETKLVLKELSEARIRTVMITGDNLQTAIT 728
Cdd:cd07542  446 EYTKQGFRVIALAYKALES-KTWLLQKLSREEVESDLEFLGLIVMENRLKPETAPVINELNRANIRTVMVTGDNLLTAIS 524
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 729 VAKNSEMIPPGSQVIIVEADEPEEFVPASVTWqlvenqetgpgkkeiymhtgnsstprgeggscyhfamsgksyqvifqh 808
Cdd:cd07542  525 VARECGMISPSKKVILIEAVKPEDDDSASLTW------------------------------------------------ 556
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 809 fnsllpKILVNGTVFARMSPGQKSSLIEEFQKLNYYVGMCGDGANDCGALKAAHAGISLSEQEASVASPFTSKTTNIQCV 888
Cdd:cd07542  557 ------TLLLKGTVFARMSPDQKSELVEELQKLDYTVGMCGDGANDCGALKAADVGISLSEAEASVAAPFTSKVPDISCV 630
                        730       740       750       760       770       780
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767926595 889 PHLIREGRAALVSSFGVFKYLTMYGIIQFISALLLYWQLQLFGNYQYLMQDVAITLMVCLT 949
Cdd:cd07542  631 PTVIKEGRAALVTSFSCFKYMALYSLIQFISVLILYSINSNLGDFQFLFIDLVIITPIAVF 691
P-ATPase-V TIGR01657
P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade ...
18-949 0e+00

P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade but the substrate of their pumping activity has yet to be determined. This clade has been designated type V in.


Pssm-ID: 273738 [Multi-domain]  Cd Length: 1054  Bit Score: 888.25  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595    18 EDELEVFGYRDHNVRKAFCLVASVLTCGGLLLVFYWRPQWRVWANCIPCPLQEADTVLLRTTDEFQrymrkkvfclyLST 97
Cdd:TIGR01657    1 DKTIGISAYKISPFKLIIYLVTLILTFGLVLLLLTWLPEWKVKLRYVPVSNEDAETVVIVDPTPNS-----------GSD 69
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595    98 LKFPVSKKWEESLVADRHSVinqaliKPELKLRCMEVQKIRYVWNDLEKRF-----QKVGLLEDSNSCSDIHqtFGLGLT 172
Cdd:TIGR01657   70 YIVELSNKSLSNDLQTENAV------EGGEEPIYFDFRKQRFSYHEKELKIfsplpYLFKEKSFGVYSTCAG--HSNGLT 141
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595   173 SEEQEVRRLVCGPNAIEVEIQPIWKLLVKQVLNPFYVFQAFTLTLWLSQGYIEYSVAIIILTVISIVLSVYDLRQQSVKL 252
Cdd:TIGR01657  142 TGDIAQRKAKYGKNEIEIPVPSFLELLKEEVLHPFYVFQVFSVILWLLDEYYYYSLCIVFMSSTSISLSVYQIRKQMQRL 221
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595   253 HNLVEDHNKVQVtiiVKDKGLEELESRLLVPGDILILP---GKfSLPCDAVLIDGSCVVNEGMLTGESIPVTKTPLPQME 329
Cdd:TIGR01657  222 RDMVHKPQSVIV---IRNGKWVTIASDELVPGDIVSIPrpeEK-TMPCDSVLLSGSCIVNESMLTGESVPVLKFPIPDNG 297
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595   330 nTMPWKCHSLEDYRKHVLFCGTEVIQVKPS-GQGPVRAVVLQTGYNTAKGDLVRSILYPRPLNFKLYSDAFKFIVFLACL 408
Cdd:TIGR01657  298 -DDDEDLFLYETSKKHVLFGGTKILQIRPYpGDTGCLAIVVRTGFSTSKGQLVRSILYPKPRVFKFYKDSFKFILFLAVL 376
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595   409 GVMGFFYALGVYMYHGVPPKDTVTMALILLTVTVPPVLPAALTIGNVYAQKRLKKKKIFCISPQRINMCGQINLVCFDKT 488
Cdd:TIGR01657  377 ALIGFIYTIIELIKDGRPLGKIILRSLDIITIVVPPALPAELSIGINNSLARLKKKGIFCTSPFRINFAGKIDVCCFDKT 456
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595   489 GTLTEDGLDLWGTVPTADNCFQEAHSFASGQAVPwSPLCAAMASCHSLILLNGTIQGDPLDLKMFEGTAWKMEDciVDSC 568
Cdd:TIGR01657  457 GTLTEDGLDLRGVQGLSGNQEFLKIVTEDSSLKP-SITHKALATCHSLTKLEGKLVGDPLDKKMFEATGWTLEE--DDES 533
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595   569 KFGTSVSNIIKPGPKASKSPVeaiitLCQFPFSSSLQRMSVIAQLAGENHFHVYMKGAPEMVARFCRSETVPKNFPQELR 648
Cdd:TIGR01657  534 AEPTSILAVVRTDDPPQELSI-----IRRFQFSSALQRMSVIVSTNDERSPDAFVKGAPETIQSLCSPETVPSDYQEVLK 608
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595   649 SYTVQGFRVIALAHKTLKMGNLSEVEHLAREKVESELTFLGLLIMENRLKKETKLVLKELSEARIRTVMITGDNLQTAIT 728
Cdd:TIGR01657  609 SYTREGYRVLALAYKELPKLTLQKAQDLSRDAVESNLTFLGFIVFENPLKPDTKEVIKELKRASIRTVMITGDNPLTAVH 688
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595   729 VAKNSEMIPPGSQVIIVEADEPEEFVPASVTWQLVENQETGPGKKEI-YMHTGNSSTPRGEggSCYHFAMSGKSYQVIFQ 807
Cdd:TIGR01657  689 VARECGIVNPSNTLILAEAEPPESGKPNQIKFEVIDSIPFASTQVEIpYPLGQDSVEDLLA--SRYHLAMSGKAFAVLQA 766
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595   808 HFNSLLPKILVNGTVFARMSPGQKSSLIEEFQKLNYYVGMCGDGANDCGALKAAHAGISLSEQEASVASPFTSKTTNIQC 887
Cdd:TIGR01657  767 HSPELLLRLLSHTTVFARMAPDQKETLVELLQKLDYTVGMCGDGANDCGALKQADVGISLSEAEASVAAPFTSKLASISC 846
                          890       900       910       920       930       940
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767926595   888 VPHLIREGRAALVSSFGVFKYLTMYGIIQFISALLLYWQLQLFGNYQYLMQDVAITLMVCLT 949
Cdd:TIGR01657  847 VPNVIREGRCALVTSFQMFKYMALYSLIQFYSVSILYLIGSNLGDGQFLTIDLLLIFPVALL 908
P-type_ATPase_cation cd02082
P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins ...
179-938 0e+00

P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins and Saccharomyces cerevisiae Ypk9p and Spf1p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Saccharomyces 1 Spf1p may mediate manganese transport into the endoplasmic reticulum. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319777 [Multi-domain]  Cd Length: 786  Bit Score: 598.81  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 179 RRLVCGPNAIEVEIQPIWKLLVKQVLNPFYVFQAFTLTLWLSQGYIEYSVAIIILTVISIVLSVYDLRQQSVklHNLVED 258
Cdd:cd02082    5 LLAYYGKNEIEINVPSFLTLMWREFKKPFNFFQYFGVILWGIDEYVYYAITVVFMTTINSLSCIYIRGVMQK--ELKDAC 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 259 HNKVQVTIIVKDKGLEELESRLLVPGDILILPGK-FSLPCDAVLIDGSCVVNEGMLTGESIPVTKTPLPQMENTMpwKCH 337
Cdd:cd02082   83 LNNTSVIVQRHGYQEITIASNMIVPGDIVLIKRReVTLPCDCVLLEGSCIVTEAMLTGESVPIGKCQIPTDSHDD--VLF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 338 SLEDYRKHVLFCGTEVIQVKPSGQGPVRAVVLQTGYNTAKGDLVRSILYPRPLNFKLYSDAFKFIVFLACLGVMGFFYAL 417
Cdd:cd02082  161 KYESSKSHTLFQGTQVMQIIPPEDDILKAIVVRTGFGTSKGQLIRAILYPKPFNKKFQQQAVKFTLLLATLALIGFLYTL 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 418 GVYMYHGVPPKDTVTMALILLTVTVPPVLPAALTIGNVYAQKRLKKKKIFCISPQRINMCGQINLVCFDKTGTLTEDGLD 497
Cdd:cd02082  241 IRLLDIELPPLFIAFEFLDILTYSVPPGLPMLIAITNFVGLKRLKKNQILCQDPNRISQAGRIQTLCFDKTGTLTEDKLD 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 498 LWGTVPTADNcfQEAHSFASGQAVPWSPLCAAMASCHSLILLNGTIQGDPLDLKMFEGTAWKMEDcivdsckfgtsvSNI 577
Cdd:cd02082  321 LIGYQLKGQN--QTFDPIQCQDPNNISIEHKLFAICHSLTKINGKLLGDPLDVKMAEASTWDLDY------------DHE 386
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 578 IKPGPKASKSPVEAIITlcQFPFSSSLQRMSVIAQLAG----ENHFHVYMKGAPEMVARFCrsETVPKNFPQELRSYTVQ 653
Cdd:cd02082  387 AKQHYSKSGTKRFYIIQ--VFQFHSALQRMSVVAKEVDmitkDFKHYAFIKGAPEKIQSLF--SHVPSDEKAQLSTLINE 462
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 654 GFRVIALAHKTLKMGNLSEVEHLAREKVESELTFLGLLIMENRLKKETKLVLKELSEARIRTVMITGDNLQTAITVAKNS 733
Cdd:cd02082  463 GYRVLALGYKELPQSEIDAFLDLSREAQEANVQFLGFIIYKNNLKPDTQAVIKEFKEACYRIVMITGDNPLTALKVAQEL 542
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 734 EMIPPGSQVIIVEADEPEEFVPASVTWQLVenqetgpgkkeiymhtgnsstprgeggscyhfamsgksyqvifqhfnsll 813
Cdd:cd02082  543 EIINRKNPTIIIHLLIPEIQKDNSTQWILI-------------------------------------------------- 572
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 814 pkilVNGTVFARMSPGQKSSLIEEFQKLNYYVGMCGDGANDCGALKAAHAGISLSEQEASVASPFTSKTTNIQCVPHLIR 893
Cdd:cd02082  573 ----IHTNVFARTAPEQKQTIIRLLKESDYIVCMCGDGANDCGALKEADVGISLAEADASFASPFTSKSTSISCVKRVIL 648
                        730       740       750       760
                 ....*....|....*....|....*....|....*....|....*
gi 767926595 894 EGRAALVSSFGVFKYLTMYGIIQFISALLLYWQLQLFGNYQYLMQ 938
Cdd:cd02082  649 EGRVNLSTSVEIFKGYALVALIRYLSFLTLYYFYSSYSSSGQMDW 693
P-type_ATPase_cation cd07543
P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 ...
184-954 6.65e-132

P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 (ATP13A1) and Saccharomyces manganese-transporting ATPase 1 Spf1p; Saccharomyces Spf1p may mediate manganese transport into the endoplasmic reticulum (ER); one consequence of deletion of SPF1 is severe ER stress. This subfamily also includes Arabidopsis thaliana MIA (Male Gametogenesis Impaired Anthers) protein which is highly abundant in the endoplasmic reticulum and small vesicles of developing pollen grains and tapetum cells. The MIA gene functionally complements a mutant in the SPF1 from Saccharomyces cerevisiae. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319843 [Multi-domain]  Cd Length: 804  Bit Score: 416.78  E-value: 6.65e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 184 GPNAIEVEIQPIWKLLVKQVLNPFYVFQAFTLTLWLSQGYIEYSVAIIILTVI---SIVlsvydlRQQSVKLHNLVEDHN 260
Cdd:cd07543   10 GKNKFDIPVPTFSELFKEHAVAPFFVFQVFCVGLWCLDEYWYYSLFTLFMLVAfeaTLV------FQRMKNLSEFRTMGN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 261 KVQVTIIVKDKGLEELESRLLVPGDIL-ILPGKFS--LPCDAVLIDGSCVVNEGMLTGESIPVTKTPLPQM--ENTMpwk 335
Cdd:cd07543   84 KPYTIQVYRDGKWVPISSDELLPGDLVsIGRSAEDnlVPCDLLLLRGSCIVNEAMLTGESVPLMKEPIEDRdpEDVL--- 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 336 cHSLEDYRKHVLFCGTEVIQVKPSGQ-------GPVRAVVLQTGYNTAKGDLVRSILYPRPLNFKLYSDAFKFIVFLacl 408
Cdd:cd07543  161 -DDDGDDKLHVLFGGTKVVQHTPPGKgglkppdGGCLAYVLRTGFETSQGKLLRTILFSTERVTANNLETFIFILFL--- 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 409 gvMGFFYALGVYMYHGVPPKDTVTMALIL-----LTVTVPPVLPAALTIGNVYAQKRLKKKKIFCISPQRINMCGQINLV 483
Cdd:cd07543  237 --LVFAIAAAAYVWIEGTKDGRSRYKLFLectliLTSVVPPELPMELSLAVNTSLIALAKLYIFCTEPFRIPFAGKVDIC 314
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 484 CFDKTGTLTEDGLDLWGTVPTADNCFQEAHSfasgQAVPWSPLcAAMASCHSLILL-NGTIQGDPLDLKMFEGTAWKME- 561
Cdd:cd07543  315 CFDKTGTLTSDDLVVEGVAGLNDGKEVIPVS----SIEPVETI-LVLASCHSLVKLdDGKLVGDPLEKATLEAVDWTLTk 389
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 562 DCIVDSCKFGTSVSNIIKpgpkaskspveaiitlcQFPFSSSLQRMSVIAQL----AGENHFHVYMKGAPEMVARFCRSe 637
Cdd:cd07543  390 DEKVFPRSKKTKGLKIIQ-----------------RFHFSSALKRMSVVASYkdpgSTDLKYIVAVKGAPETLKSMLSD- 451
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 638 tVPKNFPQELRSYTVQGFRVIALAHKTLKMGNLSEVEHLAREKVESELTFLGLLIMENRLKKETKLVLKELSEARIRTVM 717
Cdd:cd07543  452 -VPADYDEVYKEYTRQGSRVLALGYKELGHLTKQQARDYKREDVESDLTFAGFIVFSCPLKPDSKETIKELNNSSHRVVM 530
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 718 ITGDNLQTAITVAKnsemippgsQVIIVEADEPEEFVPAsvtwqlvenqetgpgkkeiymhtgnsstprgeggscyhfam 797
Cdd:cd07543  531 ITGDNPLTACHVAK---------ELGIVDKPVLILILSE----------------------------------------- 560
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 798 SGKSYQvifqhfNSLLPKIlvngTVFARMSPGQKSSLIEEFQKLNYYVGMCGDGANDCGALKAAHAGISLSE-QEASVAS 876
Cdd:cd07543  561 EGKSNE------WKLIPHV----KVFARVAPKQKEFIITTLKELGYVTLMCGDGTNDVGALKHAHVGVALLKlGDASIAA 630
                        730       740       750       760       770       780       790
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767926595 877 PFTSKTTNIQCVPHLIREGRAALVSSFGVFKYLTMYGIIQFISALLLYWQLQLFGNYQYLMQdvAITLMVCLTnqCIS 954
Cdd:cd07543  631 PFTSKLSSVSCVCHIIKQGRCTLVTTLQMFKILALNCLISAYSLSVLYLDGVKFGDVQATIS--GLLLAACFL--FIS 704
ATPase_P-type TIGR01494
ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large ...
230-945 6.41e-104

ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large family of trans-membrane transporters acting on charged substances. The distinguishing feature of the family is the formation of a phosphorylated intermediate (aspartyl-phosphate) during the course of the reaction. Another common name for these enzymes is the E1-E2 ATPases based on the two isolable conformations: E1 (unphosphorylated) and E2 (phosphorylated). Generally, P-type ATPases consist of only a single subunit encompassing the ATPase and ion translocation pathway, however, in the case of the potassium (TIGR01497) and sodium/potassium (TIGR01106) varieties, these functions are split between two subunits. Additional small regulatory or stabilizing subunits may also exist in some forms. P-type ATPases are nearly ubiquitous in life and are found in numerous copies in higher organisms (at least 45 in Arabidopsis thaliana, for instance). Phylogenetic analyses have revealed that the P-type ATPase subfamily is divided up into groups based on substrate specificities and this is represented in the various subfamily and equivalog models that have been made: IA (K+) TIGR01497, IB (heavy metals) TIGR01525, IIA1 (SERCA-type Ca++) TIGR01116, IIA2 (PMR1-type Ca++) TIGR01522, IIB (PMCA-type Ca++) TIGR01517, IIC (Na+/K+, H+/K+ antiporters) TIGR01106, IID (fungal-type Na+ and K+) TIGR01523, IIIA (H+) TIGR01647, IIIB (Mg++) TIGR01524, IV (phospholipid, flippase) TIGR01652 and V (unknown specificity) TIGR01657. The crystal structure of one calcium-pumping ATPase and an analysis of the fold of the catalytic domain of the P-type ATPases have been published. These reveal that the catalytic core of these enzymes is a haloacid dehalogenase(HAD)-type aspartate-nucleophile hydrolase. The location of the ATP-binding loop in between the first and second HAD conserved catalytic motifs defines these enzymes as members of subfamily I of the HAD superfamily (see also TIGR01493, TIGR01509, TIGR01549, TIGR01544 and TIGR01545). Based on these classifications, the P-type ATPase _superfamily_ corresponds to the IC subfamily of the HAD superfamily.


Pssm-ID: 273656 [Multi-domain]  Cd Length: 545  Bit Score: 334.67  E-value: 6.41e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595  230 IIILTVISIVLSVYDLRQQSVKLHNLvEDHNKVQVTIIVKDKGLEELESRLLVPGDILILPGKFSLPCDAVLIDGSCVVN 309
Cdd:TIGR01494   2 ILFLVLLFVLLEVKQKLKAEDALRSL-KDSLVNTATVLVLRNGWKEISSKDLVPGDVVLVKSGDTVPADGVLLSGSAFVD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595  310 EGMLTGESIPVTKTPLPQMENTMpwkchsledyRKHVLFCGTEVIQVKPSGQ---GPVRAVVLQTGYNTakgdlvRSILY 386
Cdd:TIGR01494  81 ESSLTGESLPVLKTALPDGDAVF----------AGTINFGGTLIVKVTATGIlttVGKIAVVVYTGFST------KTPLQ 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595  387 PRPLNFKLYSdafkFIVFLACLGVMGFFYALGvYMYHGVPPKDTVTMALILLTVTVPPVLPAALTIGNVYAQKRLKKKKI 466
Cdd:TIGR01494 145 SKADKFENFI----FILFLLLLALAVFLLLPI-GGWDGNSIYKAILRALAVLVIAIPCALPLAVSVALAVGDARMAKKGI 219
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595  467 FCISPQRINMCGQINLVCFDKTGTLTEDGLDLwgtvptadncfqEAHSFASGQAvpwSPLCaamaSCHSLILLNGTIQGD 546
Cdd:TIGR01494 220 LVKNLNALEELGKVDVICFDKTGTLTTNKMTL------------QKVIIIGGVE---EASL----ALALLAASLEYLSGH 280
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595  547 PLDLKMFEGTAWkmedcivDSCKFGTSVSNIIkpgpkaskspveaiitLCQFPFSSSLQRMSVIAQLAGENHFhVYMKGA 626
Cdd:TIGR01494 281 PLERAIVKSAEG-------VIKSDEINVEYKI----------------LDVFPFSSVLKRMGVIVEGANGSDL-LFVKGA 336
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595  627 PEMVARFCrseTVPKNFPQELRSYTVQGFRVIALAHKtlkmgnlsevehlareKVESELTFLGLLIMENRLKKETKLVLK 706
Cdd:TIGR01494 337 PEFVLERC---NNENDYDEKVDEYARQGLRVLAFASK----------------KLPDDLEFLGLLTFEDPLRPDAKETIE 397
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595  707 ELSEARIRTVMITGDNLQTAITVAKNSEMippgsqviiveadepeefvpasvtwqlvenqetgpgkkeiymhtgnsstpr 786
Cdd:TIGR01494 398 ALRKAGIKVVMLTGDNVLTAKAIAKELGI--------------------------------------------------- 426
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595  787 geggscyhfamsgksyqvifqhfnsllpkilvngTVFARMSPGQKSSLIEEFQKLNYYVGMCGDGANDCGALKAAHAGIS 866
Cdd:TIGR01494 427 ----------------------------------DVFARVKPEEKAAIVEALQEKGRTVAMTGDGVNDAPALKKADVGIA 472
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595  867 LSEQEASVAS---PFTSktTNIQCVPHLIREGRAALVSSFGVFKYLTMYGIIQFISALLLYwqlqlfgNYQYLMQDVAIT 943
Cdd:TIGR01494 473 MGSGDVAKAAadiVLLD--DDLSTIVEAVKEGRKTFSNIKKNIFWAIAYNLILIPLALLLI-------VIILLPPLLAAL 543

                  ..
gi 767926595  944 LM 945
Cdd:TIGR01494 544 AL 545
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
170-866 1.28e-79

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 277.37  E-value: 1.28e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 170 GLTSEEQEVRRLVCGPNAI-EVEIQPIWKLLVKQVLNPFyvfqafTLTLW-------LSQGYIEySVAIIILTVISIVLS 241
Cdd:COG0474   26 GLSSEEAARRLARYGPNELpEEKKRSLLRRFLEQFKNPL------ILILLaaavisaLLGDWVD-AIVILAVVLLNAIIG 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 242 VY-DLR-QQSV-KLHNLVEDHNKVqvtiiVKDKGLEELESRLLVPGDILIL-PGKFsLPCDAVLIDG-SCVVNEGMLTGE 316
Cdd:COG0474   99 FVqEYRaEKALeALKKLLAPTARV-----LRDGKWVEIPAEELVPGDIVLLeAGDR-VPADLRLLEAkDLQVDESALTGE 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 317 SIPVTKTPLPQMENTmpwkchSLEDyRKHVLFCGTEVIqvkpSGQGpvRAVVLQTGYNTAKG---DLVRSILYPR-PLNF 392
Cdd:COG0474  173 SVPVEKSADPLPEDA------PLGD-RGNMVFMGTLVT----SGRG--TAVVVATGMNTEFGkiaKLLQEAEEEKtPLQK 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 393 KLysDAF-KFIVFLAcLGVMGFFYALGVYmyHGVPPKDTVTMALILLTVTVPPVLPAALTI----GnvyAQKRLKKKKIf 467
Cdd:COG0474  240 QL--DRLgKLLAIIA-LVLAALVFLIGLL--RGGPLLEALLFAVALAVAAIPEGLPAVVTItlalG---AQRMAKRNAI- 310
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 468 cISpqRINMC---GQINLVCFDKTGTLTEDGL---DLWgtvpTADNCFQeahsfASGQAVP-WSPLCAAMASCHSLILLN 540
Cdd:COG0474  311 -VR--RLPAVetlGSVTVICTDKTGTLTQNKMtveRVY----TGGGTYE-----VTGEFDPaLEELLRAAALCSDAQLEE 378
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 541 GTIQGDPldlkmfegtawkMEDCIVDSC-KFGTSVSNIIKPGPKaskspveaiitLCQFPFSSSLQRMSVIAQLAGENHF 619
Cdd:COG0474  379 ETGLGDP------------TEGALLVAAaKAGLDVEELRKEYPR-----------VDEIPFDSERKRMSTVHEDPDGKRL 435
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 620 hVYMKGAPEMVARFCR-----------SETVPKNFPQELRSYTVQGFRVIALAHKTLkmgnlSEVEHLAREKVESELTFL 688
Cdd:COG0474  436 -LIVKGAPEVVLALCTrvltgggvvplTEEDRAEILEAVEELAAQGLRVLAVAYKEL-----PADPELDSEDDESDLTFL 509
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 689 GLLIMENRLKKETKLVLKELSEARIRTVMITGDNLQTAITVAKNSEMIPPGSQVIiveadepeefvpasvtwqlvenqeT 768
Cdd:COG0474  510 GLVGMIDPPRPEAKEAIAECRRAGIRVKMITGDHPATARAIARQLGLGDDGDRVL------------------------T 565
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 769 GpgkKEIymhtgnsstprgeggscyhFAMSGKSyqvifqhfnslLPKILVNGTVFARMSPGQKSSLIEEFQKLNYYVGMC 848
Cdd:COG0474  566 G---AEL-------------------DAMSDEE-----------LAEAVEDVDVFARVSPEHKLRIVKALQANGHVVAMT 612
                        730
                 ....*....|....*...
gi 767926595 849 GDGANDCGALKAAHAGIS 866
Cdd:COG0474  613 GDGVNDAPALKAADIGIA 630
P-type_ATPase_cation cd02080
P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, ...
170-867 4.02e-53

P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, and Synechocystis sp. PCC 6803 PMA1, a putative Ca(2+)-ATPase; This subfamily includes the P-type Na(+)-ATPase of an alkaliphilic bacterium Exiguobacterium aurantiacum Mna and cyanobacterium Synechocystis sp. PCC 6803 PMA1, a cation-transporting ATPase which may translocate calcium. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319775 [Multi-domain]  Cd Length: 819  Bit Score: 199.80  E-value: 4.02e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 170 GLTSEEQEVRRLVCGPNAI-EVEIQPIWKLLVKQVLNPF-YVF-QAFTLTLWLsQGYIEYSVAIIILTVISIVLSVYDLR 246
Cdd:cd02080    1 GLTSEEAAERLERYGPNRLpEKKTKSPLLRFLRQFNNPLiYILlAAAVVTAFL-GHWVDAIVIFGVVLINAIIGYIQEGK 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 247 -QQSVK-LHNLVEDHNKVqvtiiVKDKGLEELESRLLVPGDILILPGKFSLPCDAVLIDGSCV-VNEGMLTGESIPVTKT 323
Cdd:cd02080   80 aEKALAaIKNMLSPEATV-----LRDGKKLTIDAEELVPGDIVLLEAGDKVPADLRLIEARNLqIDESALTGESVPVEKQ 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 324 PLPQMENTmpwkchSLEDyRKHVLFCGTEVIqvkpSGQGpvRAVVLQTGYNTAKGDLVRSILYPR----PLNFKLysDAF 399
Cdd:cd02080  155 EGPLEEDT------PLGD-RKNMAYSGTLVT----AGSA--TGVVVATGADTEIGRINQLLAEVEqlatPLTRQI--AKF 219
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 400 KFIVFLACLGVMGFFYALGvYMYHGVPPKDTVtMALILLTV-TVPPVLPAALTIgnVYA---QKRLKKKKIFCISPQrIN 475
Cdd:cd02080  220 SKALLIVILVLAALTFVFG-LLRGDYSLVELF-MAVVALAVaAIPEGLPAVITI--TLAigvQRMAKRNAIIRRLPA-VE 294
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 476 MCGQINLVCFDKTGTLTEDGLdlwgTVPTADNCFQEAHSFASGQAvpWsplcaamaschslillngTIQGDPLDLKMfeg 555
Cdd:cd02080  295 TLGSVTVICSDKTGTLTRNEM----TVQAIVTLCNDAQLHQEDGH--W------------------KITGDPTEGAL--- 347
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 556 tawkmedcIVDSCKFGtsvsniIKPGPKASKSPVEAIItlcqfPFSSSLQRMSVIAQLAGENhfHVYMKGAPEMVARFCR 635
Cdd:cd02080  348 --------LVLAAKAG------LDPDRLASSYPRVDKI-----PFDSAYRYMATLHRDDGQR--VIYVKGAPERLLDMCD 406
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 636 SETVPKN--------FPQELRSYTVQGFRVIALAHKTLKmgnlSEVEHLAREKVESELTFLGLLIMENRLKKETKLVLKE 707
Cdd:cd02080  407 QELLDGGvspldrayWEAEAEDLAKQGLRVLAFAYREVD----SEVEEIDHADLEGGLTFLGLQGMIDPPRPEAIAAVAE 482
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 708 LSEARIRTVMITGDNLQTAITVAKnseMIPPGSQVIIVEADEPEefvpasvtwqlvenqetgpgkkeiymhtgnsstprg 787
Cdd:cd02080  483 CQSAGIRVKMITGDHAETARAIGA---QLGLGDGKKVLTGAELD------------------------------------ 523
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 788 eggscyhfAMSGKSYQVIFQHFNsllpkilvngtVFARMSPGQKSSLIEEFQKLNYYVGMCGDGANDCGALKAAHAGISL 867
Cdd:cd02080  524 --------ALDDEELAEAVDEVD-----------VFARTSPEHKLRLVRALQARGEVVAMTGDGVNDAPALKQADIGIAM 584
P-type_ATPase_Ca_prok cd02089
prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL ...
170-867 7.69e-53

prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL and Listeria monocytogenes LMCA1; Ca(2+) transport ATPase is a plasma membrane protein which pumps Ca(2+) ion out of the cytoplasm. This prokaryotic subfamily includes the Ca(2+)-ATPase Synechococcus elongatus PacL, Listeria monocytogenes Ca(2+)-ATPase 1 (LMCA1) which has a low Ca(2+) affinity and a high pH optimum (pH about 9) and may remove Ca(2+) from the microorganism in environmental conditions when e.g. stressed by high Ca(2+) and alkaline pH, and the Bacillus subtilis putative P-type Ca(2+)-transport ATPase encoded by the yloB gene, which is expressed during sporulation. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319781 [Multi-domain]  Cd Length: 674  Bit Score: 196.68  E-value: 7.69e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 170 GLTSEEQEVRRLVCGPNAI-EVEIQPIWKLLVKQvlnpfyvFQAFTLTLWLSQGYI-----EYSVAIIILTVISI--VLS 241
Cdd:cd02089    1 GLSEEEAERRLAKYGPNELvEKKKRSPWKKFLEQ-------FKDFMVIVLLAAAVIsgvlgEYVDAIVIIAIVILnaVLG 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 242 VYdlrqQSVKLHNLVEDHNK--VQVTIIVKDKGLEELESRLLVPGDILILPGKFSLPCDAVLIDG-SCVVNEGMLTGESI 318
Cdd:cd02089   74 FV----QEYKAEKALAALKKmsAPTAKVLRDGKKQEIPARELVPGDIVLLEAGDYVPADGRLIESaSLRVEESSLTGESE 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 319 PVTKTPLPQMENTMPwkchsLEDyRKHVLFCGTEVIQvkpsGQGpvRAVVLQTGYNTAKG---DLVRSILYPR-PLNFKL 394
Cdd:cd02089  150 PVEKDADTLLEEDVP-----LGD-RKNMVFSGTLVTY----GRG--RAVVTATGMNTEMGkiaTLLEETEEEKtPLQKRL 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 395 ysDAFKFIVFLACLGVMGFFYALGVymYHGVPPKDTVTMALILLTVTVPPVLPAALTIGNVY-AQKRLKKKKIFCISPQr 473
Cdd:cd02089  218 --DQLGKRLAIAALIICALVFALGL--LRGEDLLDMLLTAVSLAVAAIPEGLPAIVTIVLALgVQRMAKRNAIIRKLPA- 292
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 474 INMCGQINLVCFDKTGTLTEDGLdlwgTVptadncfqeahsfasgQAVpWsplcaamaschslillngtIQGDPLDLKMf 553
Cdd:cd02089  293 VETLGSVSVICSDKTGTLTQNKM----TV----------------EKI-Y-------------------TIGDPTETAL- 331
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 554 egtawkmedcIVDSCKFGTSVSNIIKpgpkasKSPVEAiitlcQFPFSSSLQRMSVIAQLAGEnhFHVYMKGAPEMVARF 633
Cdd:cd02089  332 ----------IRAARKAGLDKEELEK------KYPRIA-----EIPFDSERKLMTTVHKDAGK--YIVFTKGAPDVLLPR 388
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 634 CR-----------SETVPKNFPQELRSYTVQGFRVIALAHKTLKMGNLSEVEHLarekvESELTFLGLLIMENRLKKETK 702
Cdd:cd02089  389 CTyiyingqvrplTEEDRAKILAVNEEFSEEALRVLAVAYKPLDEDPTESSEDL-----ENDLIFLGLVGMIDPPRPEVK 463
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 703 LVLKELSEARIRTVMITGDNLQTAITVAKNSEMIPPGSQVII-VEADepeefvpasvtwqlvenqetgpgkkeiymhtgn 781
Cdd:cd02089  464 DAVAECKKAGIKTVMITGDHKLTARAIAKELGILEDGDKALTgEELD--------------------------------- 510
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 782 sstprgeggscyhfAMSGKSyqvifqhfnslLPKILVNGTVFARMSPGQKSSLIEEFQKLNYYVGMCGDGANDCGALKAA 861
Cdd:cd02089  511 --------------KMSDEE-----------LEKKVEQISVYARVSPEHKLRIVKALQRKGKIVAMTGDGVNDAPALKAA 565

                 ....*.
gi 767926595 862 HAGISL 867
Cdd:cd02089  566 DIGVAM 571
P-type_ATPase_Mg cd02077
magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella ...
170-866 1.41e-48

magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella typhimurium MgtA; MgtA is a membrane protein which actively transports Mg(2+) into the cytosol with its electro-chemical gradient rather than against the gradient as other cation transporters do. It may act both as a transporter and as a sensor for Mg(2+). In Salmonella typhimurium and Escherichia coli, the two-component system PhoQ/PhoP regulates the transcription of the mgtA gene by sensing Mg(2+) concentrations in the periplasm. MgtA is activated by cardiolipin and it highly sensitive to free magnesium in vitro. It consists of a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319772 [Multi-domain]  Cd Length: 768  Bit Score: 185.53  E-value: 1.41e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 170 GLTSEEQEVRRLVCGPNAIEVE-IQPIWKLLVKQVLNPFyVFQAFTLTL-------WLSQGYIEYSVAIIILTVI--SIV 239
Cdd:cd02077    1 GLTNEEAEERLEKYGPNEISHEkFPSWFKLLLKAFINPF-NIVLLVLALvsfftdvLLAPGEFDLVGALIILLMVliSGL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 240 LSVYdlrqQSVKLHNLVED-HNKVQVTIIVKDKGL--EELESRLLVPGDILILPGKFSLPCDAVLIDGS-CVVNEGMLTG 315
Cdd:cd02077   80 LDFI----QEIRSLKAAEKlKKMVKNTATVIRDGSkyMEIPIDELVPGDIVYLSAGDMIPADVRIIQSKdLFVSQSSLTG 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 316 ESIPVTKTPLPQMEntmpwKCHSLEDYRKhVLFCGTEVIqvkpSGQGpvRAVVLQTGYNTAKGDLVRSILYPRPLN-FK- 393
Cdd:cd02077  156 ESEPVEKHATAKKT-----KDESILELEN-ICFMGTNVV----SGSA--LAVVIATGNDTYFGSIAKSITEKRPETsFDk 223
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 394 -LYSDAFKFIVFLAclgVMGFFyalgVYMYHGVPPKDTVTMALILLTVTV---PPVLPAALTIGNVYAQKRLKKKKIFCI 469
Cdd:cd02077  224 gINKVSKLLIRFML---VMVPV----VFLINGLTKGDWLEALLFALAVAVgltPEMLPMIVTSNLAKGAVRMSKRKVIVK 296
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 470 SPQRINMCGQINLVCFDKTGTLTEDGLDLwgtvptadncfqEAHSFASGQAvpwSPLCAAMAschsliLLNGTIQG---D 546
Cdd:cd02077  297 NLNAIQNFGAMDILCTDKTGTLTQDKIVL------------ERHLDVNGKE---SERVLRLA------YLNSYFQTglkN 355
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 547 PLDLKMFEGtawkmedciVDSCKFGTSVSNIIKpgpkaskspVEAIitlcqfPFSSSLQRMSVIAQLAGENHFHVyMKGA 626
Cdd:cd02077  356 LLDKAIIDH---------AEEANANGLIQDYTK---------IDEI------PFDFERRRMSVVVKDNDGKHLLI-TKGA 410
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 627 PEMVARFCR-----------SETVPKNFPQELRSYTVQGFRVIALAHKtlkmgNLSEVEHLAREKVESELTFLGLLIMEN 695
Cdd:cd02077  411 VEEILNVCThvevngevvplTDTLREKILAQVEELNREGLRVLAIAYK-----KLPAPEGEYSVKDEKELILIGFLAFLD 485
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 696 RLKKETKLVLKELSEARIRTVMITGDNLQTAITVAKNSEMipPGSQVII---VEADEPEEfvpasvtwqlvenqetgpgk 772
Cdd:cd02077  486 PPKESAAQAIKALKKNGVNVKILTGDNEIVTKAICKQVGL--DINRVLTgseIEALSDEE-------------------- 543
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 773 keiymhtgnsstprgeggscyhfamsgksyqvifqhfnslLPKILVNGTVFARMSPGQKSSLIEEFQKLNYYVGMCGDGA 852
Cdd:cd02077  544 ----------------------------------------LAKIVEETNIFAKLSPLQKARIIQALKKNGHVVGFMGDGI 583
                        730
                 ....*....|....
gi 767926595 853 NDCGALKAAHAGIS 866
Cdd:cd02077  584 NDAPALRQADVGIS 597
P-type_ATPase_Na_ENA cd02086
fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces ...
170-897 1.80e-42

fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces cerevisiae Ena1p, Ena2p and Ustilago maydis Ena1, and the endoplasmic reticulum sodium transporter Ustilago maydis Ena2; Fungal-type Na(+)-ATPase (also called ENA ATPases). This subfamily includes the Saccharomyces cerevisiae plasma membrane transporters: Na(+)/Li(+)-exporting ATPase Ena1p which may also extrudes K(+), and Na(+)-exporting P-type ATPase Ena2p. It also includes Ustilago maydis plasma membrane Ena1, an K(+)/Na(+)-ATPase whose chief role is to pump Na(+) and K(+) out of the cytoplasm, especially at high pH values, and endoplasmic reticulum Ena2 ATPase which mediates Na(+) or K(+) fluxes in the ER or in other endomembranes. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319780 [Multi-domain]  Cd Length: 920  Bit Score: 168.02  E-value: 1.80e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 170 GLTSEEQEVRRLVCGPNAIE--VEIQPiWKLLVKQVLNpfyvfqAFTLTLWLSQG-------YIEYSV--AIIILTVISI 238
Cdd:cd02086    1 GLTNDEAERRLKEYGENELEgdTGVSA-WKILLRQVAN------AMTLVLIIAMAlsfavkdWIEGGViaAVIALNVIVG 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 239 VLSVYDLRQQSVKLHNLVEDHNKVqvtiiVKDKGLEELESRLLVPGDILILPGKFSLPCDAVLIDGSCV-VNEGMLTGES 317
Cdd:cd02086   74 FIQEYKAEKTMDSLRNLSSPNAHV-----IRSGKTETISSKDVVPGDIVLLKVGDTVPADLRLIETKNFeTDEALLTGES 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 318 IPVTKT--PLPQMENTMPwkchsLEDyRKHVLFCGTEVIQvkpsgqGPVRAVVLQTGYNTAKGDLVRSI----------- 384
Cdd:cd02086  149 LPVIKDaeLVFGKEEDVS-----VGD-RLNLAYSSSTVTK------GRAKGIVVATGMNTEIGKIAKALrgkgglisrdr 216
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 385 ----LYPRPLNFKLYSDAF--------------KFIVFLACLGVMgffYALGVYMYHGVPPKDTVTMALILLTVTV-PPV 445
Cdd:cd02086  217 vkswLYGTLIVTWDAVGRFlgtnvgtplqrklsKLAYLLFFIAVI---LAIIVFAVNKFDVDNEVIIYAIALAISMiPES 293
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 446 LPAALTIGNVYAQKRLKKKKIFCISPQRINMCGQINLVCFDKTGTLTEDGL---DLWGTVPTADNcfqeAHSFASGQAVP 522
Cdd:cd02086  294 LVAVLTITMAVGAKRMVKRNVIVRKLDALEALGAVTDICSDKTGTLTQGKMvvrQVWIPAALCNI----ATVFKDEETDC 369
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 523 WsplcaamaschslillngTIQGDPLD--LKMFegtawkmedcivdSCKFGTSVSNIIKPGpKASKSPVEaiitlcQFPF 600
Cdd:cd02086  370 W------------------KAHGDPTEiaLQVF-------------ATKFDMGKNALTKGG-SAQFQHVA------EFPF 411
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 601 SSSLQRMSVIAQLAGENHFHVYMKGAPEMVARFCRS-----------ETVPKNFPQELRSYTVQGFRVIALAHKTL---- 665
Cdd:cd02086  412 DSTVKRMSVVYYNNQAGDYYAYMKGAVERVLECCSSmygkdgiipldDEFRKTIIKNVESLASQGLRVLAFASRSFtkaq 491
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 666 KMGNLSEVEHLAREKVESELTFLGLLIMENRLKKETKLVLKELSEARIRTVMITGDNLQTAITVAKNSEMIPPGSqviiv 745
Cdd:cd02086  492 FNDDQLKNITLSRADAESDLTFLGLVGIYDPPRNESAGAVEKCHQAGITVHMLTGDHPGTAKAIAREVGILPPNS----- 566
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 746 eADEPEEFVPASVtwqLVENQETGPGKKEIymhtgnsstprgeggscyhfamsgksyqvifqhfNSL--LPkilvngTVF 823
Cdd:cd02086  567 -YHYSQEIMDSMV---MTASQFDGLSDEEV----------------------------------DALpvLP------LVI 602
                        730       740       750       760       770       780       790
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767926595 824 ARMSPGQKSSLIEEFQKLNYYVGMCGDGANDCGALKAAHAGISLSEQEASVA---SPFTSKTTNIQCVPHLIREGRA 897
Cdd:cd02086  603 ARCSPQTKVRMIEALHRRKKFCAMTGDGVNDSPSLKMADVGIAMGLNGSDVAkdaSDIVLTDDNFASIVNAIEEGRR 679
P-type_ATPase cd07539
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
229-875 2.16e-42

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319840 [Multi-domain]  Cd Length: 634  Bit Score: 164.90  E-value: 2.16e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 229 AIIILTVISI-VLSVYDLRQQSVKLHNLVEDHNKVQVTIIVKDKG-LEELESRLLVPGDILILPGKFSLPCDAVLIDGSC 306
Cdd:cd07539   60 AVLIVGVLTVnAVIGGVQRLRAERALAALLAQQQQPARVVRAPAGrTQTVPAESLVPGDVIELRAGEVVPADARLLEADD 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 307 V-VNEGMLTGESIPVTKT--PLPQMEntmpwkchsLEDyRKHVLFCGTEVIqvkpSGQGpvRAVVLQTGYNTAKG---DL 380
Cdd:cd07539  140 LeVDESALTGESLPVDKQvaPTPGAP---------LAD-RACMLYEGTTVV----SGQG--RAVVVATGPHTEAGraqSL 203
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 381 VRSILYPRPLNFKLysDAFKFIVFLACLGVMGFFYALGVYmyHGVPPKDTVTMALILLTVTVPPVLPAALTIGNVYAQKR 460
Cdd:cd07539  204 VAPVETATGVQAQL--RELTSQLLPLSLGGGAAVTGLGLL--RGAPLRQAVADGVSLAVAAVPEGLPLVATLAQLAAARR 279
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 461 LKKKKIFCISPQRINMCGQINLVCFDKTGTLTEDGLdlwgtvptadncfqeahsfasgqavpwsplcaamaschslilln 540
Cdd:cd07539  280 LSRRGVLVRSPRTVEALGRVDTICFDKTGTLTENRL-------------------------------------------- 315
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 541 gtiqgdpldlkmfegtawkmedcivdsckfgtSVSNIIKPgpkaskspveaiitLCQFPFSSSLQRMSVIAQLAGENHFh 620
Cdd:cd07539  316 --------------------------------RVVQVRPP--------------LAELPFESSRGYAAAIGRTGGGIPL- 348
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 621 VYMKGAPEMVARFC---RSETVPKNFPQELRSYTV--------QGFRVIALAHKTLKMGnlsevEHLAREKVESELTFLG 689
Cdd:cd07539  349 LAVKGAPEVVLPRCdrrMTGGQVVPLTEADRQAIEevnellagQGLRVLAVAYRTLDAG-----TTHAVEAVVDDLELLG 423
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 690 LLIMENRLKKETKLVLKELSEARIRTVMITGDNLQTAITVAKNSEMippGSQVIIVEADEPEEfvpasvtwqLVENQETG 769
Cdd:cd07539  424 LLGLADTARPGAAALIAALHDAGIDVVMITGDHPITARAIAKELGL---PRDAEVVTGAELDA---------LDEEALTG 491
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 770 pgkkeiymhtgnsstprgeggscyhfamsgksyqvifqhfnsLLPKIlvngTVFARMSPGQKSSLIEEFQKLNYYVGMCG 849
Cdd:cd07539  492 ------------------------------------------LVADI----DVFARVSPEQKLQIVQALQAAGRVVAMTG 525
                        650       660
                 ....*....|....*....|....*.
gi 767926595 850 DGANDCGALKAAHAGISLSEQEASVA 875
Cdd:cd07539  526 DGANDAAAIRAADVGIGVGARGSDAA 551
P-type_ATPase_H cd02076
plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+) ...
170-868 3.64e-39

plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+)-ATPases; This subfamily includes eukaryotic plasma membrane H(+)-ATPase which transports H(+) from the cytosol to the extracellular space, thus energizing the plasma membrane for the uptake of ions and nutrients, and is expressed in plants and fungi. This H(+)-ATPase consists of four domains: a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. This subfamily also includes the putative P-type H(+)-ATPase, MJ1226p of the anaerobic hyperthermophilic archaea Methanococcus jannaschii. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319771 [Multi-domain]  Cd Length: 781  Bit Score: 156.62  E-value: 3.64e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 170 GLTSEEQEVRRLVCGPNAIEVEIQPIWKLLVKQVLNPF-YVFQAFTLTLWLSQGYIEYSVaIIILTVISIVLSVYdlrqQ 248
Cdd:cd02076    1 GLTSEEAAKRLKEYGPNELPEKKENPILKFLSFFWGPIpWMLEAAAILAAALGDWVDFAI-ILLLLLINAGIGFI----E 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 249 SVKLHNLVED-HNKVQVTIIVK-DKGLEELESRLLVPGDILILPGKFSLPCDAVLIDGSCV-VNEGMLTGESIPVTKTPl 325
Cdd:cd02076   76 ERQAGNAVAAlKKSLAPKARVLrDGQWQEIDAKELVPGDIVSLKIGDIVPADARLLTGDALqVDQSALTGESLPVTKHP- 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 326 pqmentmpwkchsledyrKHVLFCGTEVIqvkpsgQGPVRAVVLQTGYNTAKG---DLVRSIlyPRPLNF-KLYSdafKF 401
Cdd:cd02076  155 ------------------GDEAYSGSIVK------QGEMLAVVTATGSNTFFGktaALVASA--EEQGHLqKVLN---KI 205
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 402 IVFLACLGVMGFFYALGVYMYHGVPPKDTVTMALILLTVTVPPVLPAALTIGNVYAQKRLKKKKIFCispQR---INMCG 478
Cdd:cd02076  206 GNFLILLALILVLIIVIVALYRHDPFLEILQFVLVLLIASIPVAMPAVLTVTMAVGALELAKKKAIV---SRlsaIEELA 282
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 479 QINLVCFDKTGTLTEDGLDLwgtvptADNCFQEAHS-----FASGQAVPWSPLcaamaschslillngtiqgDPLDLKMF 553
Cdd:cd02076  283 GVDILCSDKTGTLTLNKLSL------DEPYSLEGDGkdellLLAALASDTENP-------------------DAIDTAIL 337
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 554 EGTAWKMEDCivdsckfgtsvsniikpgpkaskspveAIITLCQF-PFSSSLQRMSVIAQLAGENHFHVyMKGAPEMVAR 632
Cdd:cd02076  338 NALDDYKPDL---------------------------AGYKQLKFtPFDPVDKRTEATVEDPDGERFKV-TKGAPQVILE 389
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 633 FC-RSETVPKNFPQELRSYTVQGFRviALAhktlkmgnlsevehLAREKVESELTFLGLLIMENRLKKETKLVLKELSEA 711
Cdd:cd02076  390 LVgNDEAIRQAVEEKIDELASRGYR--SLG--------------VARKEDGGRWELLGLLPLFDPPRPDSKATIARAKEL 453
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 712 RIRTVMITGDNLQTAITVAKNSEMippGSQVIiveadEPEEFvpasvtwqlvenqetGPGKKEIYMHtgnsstprgeggs 791
Cdd:cd02076  454 GVRVKMITGDQLAIAKETARQLGM---GTNIL-----SAERL---------------KLGGGGGGMP------------- 497
                        650       660       670       680       690       700       710
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767926595 792 cyhfamSGKSYQVIFQhfnsllpkilVNGtvFARMSPGQKSSLIEEFQKLNYYVGMCGDGANDCGALKAAHAGISLS 868
Cdd:cd02076  498 ------GSELIEFIED----------ADG--FAEVFPEHKYRIVEALQQRGHLVGMTGDGVNDAPALKKADVGIAVS 556
P-type_ATPase_Ca_PMCA-like cd02081
animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related ...
179-867 7.42e-38

animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related Ca2(+)-ATPases including Saccharomyces cerevisiae vacuolar PMC1; Animal PMCAs function to export Ca(2+) from cells and play a role in regulating Ca(2+) signals following stimulus induction and in preventing calcium toxicity. Many PMCA pump variants exist due to alternative splicing of transcripts. PMCAs are regulated by the binding of calmodulin or by kinase-mediated phosphorylation. Saccharomyces cerevisiae vacuolar transporter Pmc1p facilitates the accumulation of Ca2+ into vacuoles. Pmc1p is not regulated by direct calmodulin binding but responds to the calmodulin/calcineurin-signaling pathway and is controlled by the transcription factor complex Tcn1p/Crz1p. Similarly, the expression of the gene for Dictyostelium discoideum Ca(2+)-ATPase PAT1, patA, is under the control of a calcineurin-dependent transcription factor. Plant vacuolar Ca(2+)-ATPases, are regulated by direct-calmodulin binding. Plant Ca(2+)-ATPases are present at various cellular locations including the plasma membrane, endoplasmic reticulum, chloroplast and vacuole. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319776 [Multi-domain]  Cd Length: 721  Bit Score: 151.97  E-value: 7.42e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 179 RRLVCGPNAI-EVEIQPIWKLLVKqvlnpfyVFQAFTL---------TLWLS-----------QGYIEySVAIIILTVIS 237
Cdd:cd02081    4 RREVYGKNEIpPKPPKSFLQLVWE-------ALQDPTLiilliaaivSLGLGfytpfgegegkTGWIE-GVAILVAVILV 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 238 IVLSV---YDLRQQSVKLHNLVEDHnKVQVtiiVKDKGLEELESRLLVPGDILILPGKFSLPCDAVLIDG-SCVVNEGML 313
Cdd:cd02081   76 VLVTAgndYQKEKQFRKLNSKKEDQ-KVTV---IRDGEVIQISVFDIVVGDIVQLKYGDLIPADGLLIEGnDLKIDESSL 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 314 TGESIPVTKTPLPQMENTMpwkchsledyrkhvLFCGTEVIqvkpSGQGpvRAVVLQTGYNTAKGDLVRSILY----PRP 389
Cdd:cd02081  152 TGESDPIKKTPDNQIPDPF--------------LLSGTKVL----EGSG--KMLVTAVGVNSQTGKIMTLLRAeneeKTP 211
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 390 LNFKL------------YSDAFKFIVFLACLGVMGFFyalgvyMYHGVPPKDTVTM-------ALILLTVTVPPVLPAAL 450
Cdd:cd02081  212 LQEKLtklavqigkvglIVAALTFIVLIIRFIIDGFV------NDGKSFSAEDLQEfvnffiiAVTIIVVAVPEGLPLAV 285
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 451 TIGNVYAQKRLKKKKifcispqriNM------C---GQINLVCFDKTGTLTEDGLdlwgTVPtadncfqeahsfasgQAV 521
Cdd:cd02081  286 TLSLAYSVKKMMKDN---------NLvrhldaCetmGNATAICSDKTGTLTQNRM----TVV---------------QGY 337
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 522 PWSPL-CAamaschsliLLNgtiqgdpldlkmfegtaWKMEDCIVDSCKFGTSVSNIIKpgpkaskspveaiitlcQFPF 600
Cdd:cd02081  338 IGNKTeCA---------LLG-----------------FVLELGGDYRYREKRPEEKVLK-----------------VYPF 374
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 601 SSSLQRMSVIAQLaGENHFHVYMKGAPEMVARFC------------RSETVPKNFPQELRSYTVQGFRVIALAHKTLKMG 668
Cdd:cd02081  375 NSARKRMSTVVRL-KDGGYRLYVKGASEIVLKKCsyilnsdgevvfLTSEKKEEIKRVIEPMASDSLRTIGLAYRDFSPD 453
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 669 N--LSEVEHLAREKVESELTFLGLLIMENRLKKETKLVLKELSEARIRTVMITGDNLQTAITVAKNSEMIPPGSQVIIVE 746
Cdd:cd02081  454 EepTAERDWDDEEDIESDLTFIGIVGIKDPLRPEVPEAVAKCQRAGITVRMVTGDNINTARAIARECGILTEGEDGLVLE 533
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 747 ADEPEEFVpasvtwqlvenqetgpgkkeiymhtgnsstpRGEGGscyhfamsgksyQVIFQHFNSLLPKIlvngTVFARM 826
Cdd:cd02081  534 GKEFRELI-------------------------------DEEVG------------EVCQEKFDKIWPKL----RVLARS 566
                        730       740       750       760
                 ....*....|....*....|....*....|....*....|.
gi 767926595 827 SPGQKSSLIEEFQKLNYYVGMCGDGANDCGALKAAHAGISL 867
Cdd:cd02081  567 SPEDKYTLVKGLKDSGEVVAVTGDGTNDAPALKKADVGFAM 607
P-type_ATPase_SPCA cd02085
golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory ...
179-875 1.15e-37

golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory pathway Ca(2+) transporting 1/hSPCA1 and Saccharomyces cerevisiae Ca(2+)/Mn(2+)-transporting P-type ATPase, Pmr1p; SPCAs are Ca(2+) pumps important for the golgi-associated secretion pathway, in addition some function as Mn(2+) pumps in Mn(2+) detoxification. Saccharomyces cerevisiae Pmr1p is a high affinity Ca(2+)/Mn(2+) ATPase which transports Ca(2+) and Mn(2+) from the cytoplasm into the Golgi. Pmr1p also contributes to Cd(2+) detoxification. This subfamily includes human SPCA1 and SPCA2, encoded by the ATP2C1 and ATP2C2 genes; autosomal dominant Hailey-Hailey disease is caused by mutations in the human ATP2C1 gene. It also includes Strongylocentrotus purpuratus testis secretory pathway calcium transporting ATPase SPCA which plays an important role in fertilization. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319779 [Multi-domain]  Cd Length: 804  Bit Score: 152.17  E-value: 1.15e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 179 RRLVCGPNAIEVE-IQPIWKLLVKQVLNPFyvfqaftLTLWLSQGYI-----EYSVAIIILTVISIVLSV-----YDLRQ 247
Cdd:cd02085    1 RRKLHGPNEFKVEdEEPLWKKYLEQFKNPL-------ILLLLGSAVVsvvmkQYDDAVSITVAILIVVTVafvqeYRSEK 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 248 QSVKLHNLV--EDHnkvqvtiIVKDKGLEELESRLLVPGDILILPGKFSLPCDAVLIDG-SCVVNEGMLTGESIPVTKTP 324
Cdd:cd02085   74 SLEALNKLVppECH-------CLRDGKLEHFLARELVPGDLVCLSIGDRIPADLRLFEAtDLSIDESSLTGETEPCSKTT 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 325 LPQMENTMPwKCHSledyRKHVLFCGTEViqvkPSGQGpvRAVVLQTGYNTAKGDLVR---SILYPR-PLNfKLYSDAFK 400
Cdd:cd02085  147 EVIPKASNG-DLTT----RSNIAFMGTLV----RCGHG--KGIVIGTGENSEFGEVFKmmqAEEAPKtPLQ-KSMDKLGK 214
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 401 FIVFLAcLGVMGFFYALGvyMYHGVPPKDTVTMALILLTVTVPPVLPAALTIGNVYAQKRLKKKKIFCISPQRINMCGQI 480
Cdd:cd02085  215 QLSLYS-FIIIGVIMLIG--WLQGKNLLEMFTIGVSLAVAAIPEGLPIVVTVTLALGVMRMAKRRAIVKKLPIVETLGCV 291
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 481 NLVCFDKTGTLTEDGLdlwgtvptadncfqEAHSFASGqavpwsplcaamASCHSLILLNGTIQGDPLDLKMfegtawkm 560
Cdd:cd02085  292 NVICSDKTGTLTKNEM--------------TVTKIVTG------------CVCNNAVIRNNTLMGQPTEGAL-------- 337
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 561 edcIVDSCKFGTSvsniikpgpkaskSPVEAIITLCQFPFSSSLQRMSVIAQLAGENHFH--VYMKGAPEMVARFCRSET 638
Cdd:cd02085  338 ---IALAMKMGLS-------------DIRETYIRKQEIPFSSEQKWMAVKCIPKYNSDNEeiYFMKGALEQVLDYCTTYN 401
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 639 VPKN------------FPQELRSYTVQGFRVIALAHKTLkMGNlsevehlarekveseLTFLGLLIMENRLKKETKLVLK 706
Cdd:cd02085  402 SSDGsalpltqqqrseINEEEKEMGSKGLRVLALASGPE-LGD---------------LTFLGLVGINDPPRPGVREAIQ 465
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 707 ELSEARIRTVMITGDNLQTAITVAKNSEMIPPGSQviiveadepeefvpasvtwqlvenqetgpgkkeiymhtgnsstpr 786
Cdd:cd02085  466 ILLESGVRVKMITGDAQETAIAIGSSLGLYSPSLQ--------------------------------------------- 500
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 787 geggscyhfAMSGKSYQVIFQHfnsLLPKILVNGTVFARMSPGQKSSLIEEFQKLNYYVGMCGDGANDCGALKAAHAGIS 866
Cdd:cd02085  501 ---------ALSGEEVDQMSDS---QLASVVRKVTVFYRASPRHKLKIVKALQKSGAVVAMTGDGVNDAVALKSADIGIA 568

                 ....*....
gi 767926595 867 LSEQEASVA 875
Cdd:cd02085  569 MGRTGTDVC 577
ATPase-IID_K-Na TIGR01523
potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium ...
170-896 4.67e-37

potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium efflux ATPase, more recent work has shown that the S. pombe CTA3 gene is in fact a potassium ion efflux pump. This model describes the clade of fungal P-type ATPases responsible for potassium and sodium efflux. The degree to which these pumps show preference for sodium or potassium varies. This group of ATPases has been classified by phylogentic analysis as type IID. The Leishmania sequence (GP|3192903), which falls between trusted and noise in this model, may very well turn out to be an active potassium pump.


Pssm-ID: 130586 [Multi-domain]  Cd Length: 1053  Bit Score: 151.32  E-value: 4.67e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595   170 GLTSEEQEVRRLVCGPNAIEVEIQ-PIWKLLVKQVLNPFYVFQ------AFTLTLWLSQGYIEysvAIIILTVISIVLSV 242
Cdd:TIGR01523   26 GLTHDEAQHRLKEVGENRLEADSGiDAKAMLLHQVCNAMCMVLiiaaaiSFAMHDWIEGGVIS---AIIALNILIGFIQE 102
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595   243 YDLRQQSVKLHNLVEDHNKVqvtiiVKDKGLEELESRLLVPGDILILPGKFSLPCDAVLIDGSCV-VNEGMLTGESIPVT 321
Cdd:TIGR01523  103 YKAEKTMDSLKNLASPMAHV-----IRNGKSDAIDSHDLVPGDICLLKTGDTIPADLRLIETKNFdTDEALLTGESLPVI 177
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595   322 KTP--LPQMENTMPwkchsLEDyRKHVLFCGTEVIqvkpsgQGPVRAVVLQTGYNTAKGDLVRSI-----LYPRPLNF-- 392
Cdd:TIGR01523  178 KDAhaTFGKEEDTP-----IGD-RINLAFSSSAVT------KGRAKGICIATALNSEIGAIAAGLqgdggLFQRPEKDdp 245
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595   393 --------------KLYSDAF--------------KFIVFLACLGVMgffYALGVYMYHGVPPKDTVTMALILLTVT-VP 443
Cdd:TIGR01523  246 nkrrklnkwilkvtKKVTGAFlglnvgtplhrklsKLAVILFCIAII---FAIIVMAAHKFDVDKEVAIYAICLAISiIP 322
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595   444 PVLPAALTIGNVYAQKRLKKKKIFCISPQRINMCGQINLVCFDKTGTLTEDGL---DLW------GTVPTADNCFQEAHS 514
Cdd:TIGR01523  323 ESLIAVLSITMAMGAANMSKRNVIVRKLDALEALGAVNDICSDKTGTITQGKMiarQIWiprfgtISIDNSDDAFNPNEG 402
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595   515 FASG---------------------------------------QAVPWSPLCaAMASCHSLILLNGT----IQGDPLD-- 549
Cdd:TIGR01523  403 NVSGiprfspyeyshneaadqdilkefkdelkeidlpedidmdLFIKLLETA-ALANIATVFKDDATdcwkAHGDPTEia 481
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595   550 LKMFEGTAWKMEDCIVDSCKFGTSVSNIIKPGPKASKSPVEAIIT-LCQFPFSSSLQRMSVIAQLAGENHFHVYMKGAPE 628
Cdd:TIGR01523  482 IHVFAKKFDLPHNALTGEEDLLKSNENDQSSLSQHNEKPGSAQFEfIAEFPFDSEIKRMASIYEDNHGETYNIYAKGAFE 561
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595   629 MVARFCRS-----------------ETVPKNfpqeLRSYTVQGFRVIALAHKTLKMGNLSE----VEHLAREKVESELTF 687
Cdd:TIGR01523  562 RIIECCSSsngkdgvkispledcdrELIIAN----MESLAAEGLRVLAFASKSFDKADNNDdqlkNETLNRATAESDLEF 637
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595   688 LGLLIMENRLKKETKLVLKELSEARIRTVMITGDNLQTAITVAKNSEMIPPGsqvIIVEADEpeefvpaSVTWQLvenqe 767
Cdd:TIGR01523  638 LGLIGIYDPPRNESAGAVEKCHQAGINVHMLTGDFPETAKAIAQEVGIIPPN---FIHDRDE-------IMDSMV----- 702
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595   768 tgpgkkeiymhtgnsstprgeggscyhfaMSGKSYQVIFQHFNSLLPKILVngtVFARMSPGQKSSLIEEFQKLNYYVGM 847
Cdd:TIGR01523  703 -----------------------------MTGSQFDALSDEEVDDLKALCL---VIARCAPQTKVKMIEALHRRKAFCAM 750
                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|..
gi 767926595   848 CGDGANDCGALKAAHAGISLSEQEASV---ASPFTSKTTNIQCVPHLIREGR 896
Cdd:TIGR01523  751 TGDGVNDSPSLKMANVGIAMGINGSDVakdASDIVLSDDNFASILNAIEEGR 802
P5-ATPase pfam12409
P5-type ATPase cation transporter; This domain family is found in eukaryotes, and is typically ...
17-142 2.46e-35

P5-type ATPase cation transporter; This domain family is found in eukaryotes, and is typically between 110 and 126 amino acids in length. The family is found in association with pfam00122, pfam00702. P-type ATPases comprise a large superfamily of proteins, present in both prokaryotes and eukaryotes, that transport inorganic cations and other substrates across cell membranes.


Pssm-ID: 463565  Cd Length: 123  Bit Score: 130.36  E-value: 2.46e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595   17 EEDELEVFGYRDHNVRKAFCLVASVLTCGGLLLVFYWRPQWRVWANCIPCPLQEADTVLLRttDEFQRYMRKKVFCLY-- 94
Cdd:pfam12409   1 EDLTIEIAGYRTSRWRLALYLLLCVLTLGLLYLLFRWLPRWRVRLTGKPCPLAEADWVVIE--DEFGELSIKKVKKLPyg 78
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 767926595   95 --LSTLKFPvsKKWEESLVADRHSVINQALIKpelKLRCMEVQKIRYVWN 142
Cdd:pfam12409  79 rpLSTVFPL--LVGESSSVISKADEDNDPELP---QLRYFDYRYIRYIWH 123
P-type_ATPases cd01431
ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, ...
597-930 1.52e-34

ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319764 [Multi-domain]  Cd Length: 319  Bit Score: 134.89  E-value: 1.52e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 597 QFPFSSSLQRMSVIAQLAGenHFHVYMKGAPEMVARFCRSETVPKNFPQELRSYT---VQGFRVIALAHKTLKMGNlsev 673
Cdd:cd01431   24 EIPFNSTRKRMSVVVRLPG--RYRAIVKGAPETILSRCSHALTEEDRNKIEKAQEesaREGLRVLALAYREFDPET---- 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 674 ehlAREKVESELTFLGLLIMENRLKKETKLVLKELSEARIRTVMITGDNLQTAITVAKNSEMIPPGSQVIIVEADEpeef 753
Cdd:cd01431   98 ---SKEAVELNLVFLGLIGLQDPPRPEVKEAIAKCRTAGIKVVMITGDNPLTAIAIAREIGIDTKASGVILGEEAD---- 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 754 vpasvtwqlvenqetgpgkkeiymhtgnsstprgeggscyhfAMSGKSYQvifqhfnsllpKILVNGTVFARMSPGQKSS 833
Cdd:cd01431  171 ------------------------------------------EMSEEELL-----------DLIAKVAVFARVTPEQKLR 197
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 834 LIEEFQKLNYYVGMCGDGANDCGALKAAHAGISLSEQEASVA---SPFTSKTTNIQCVPHLIREGRAALVSsfgVFKYLT 910
Cdd:cd01431  198 IVKALQARGEVVAMTGDGVNDAPALKQADVGIAMGSTGTDVAkeaADIVLLDDNFATIVEAVEEGRAIYDN---IKKNIT 274
                        330       340
                 ....*....|....*....|....*.
gi 767926595 911 M------YGIIQFISALLLYWQLQLF 930
Cdd:cd01431  275 YllannvAEVFAIALALFLGGPLPLL 300
P-type_ATPase cd07538
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
170-875 4.74e-34

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319839 [Multi-domain]  Cd Length: 653  Bit Score: 139.50  E-value: 4.74e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 170 GLTSEEQEVRRLVCGPNAIeveIQPIWKLLVKQVLN----PFYVFQAFTLTLWLSQGYIEYSVAIIILTVISIVLSVYDL 245
Cdd:cd07538    1 GLTEAEARRRLESGGKNEL---PQPKKRTLLASILDvlrePMFLLLLAAALIYFVLGDPREGLILLIFVVVIIAIEVVQE 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 246 RQQSVKLHNLvEDHNKVQVTIIvKDKGLEELESRLLVPGDILILPGKFSLPCDAVLIDGSCV-VNEGMLTGESIPVTKTP 324
Cdd:cd07538   78 WRTERALEAL-KNLSSPRATVI-RDGRERRIPSRELVPGDLLILGEGERIPADGRLLENDDLgVDESTLTGESVPVWKRI 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 325 -LPQMENTMPWKchsledyrKHVLFCGTEVIQvkpsGQGPVRavVLQTGYNTAKGDLVRSIL----YPRPLN---FKLYS 396
Cdd:cd07538  156 dGKAMSAPGGWD--------KNFCYAGTLVVR----GRGVAK--VEATGSRTELGKIGKSLAemddEPTPLQkqtGRLVK 221
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 397 DAFKFIVFLACLGVMGFFYALGVYM---YHGVppkdTVTMALIlltvtvPPVLPAALTIGNVYAQKRLKKKKIFCISPQR 473
Cdd:cd07538  222 LCALAALVFCALIVAVYGVTRGDWIqaiLAGI----TLAMAMI------PEEFPVILTVFMAMGAWRLAKKNVLVRRAAA 291
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 474 INMCGQINLVCFDKTGTLTEDGLDLWGTVptadncfQEAHSFasgqavPWSPLCAAMaschslillngtiqgdpldlkmf 553
Cdd:cd07538  292 VETLGSITVLCVDKTGTLTKNQMEVVELT-------SLVREY------PLRPELRMM----------------------- 335
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 554 eGTAWKMEDCIVdsckfgtsvsniikpgpkaskspveaiitlcqfpfssslqrmsviaqlagenhfhVYMKGAPEMVARF 633
Cdd:cd07538  336 -GQVWKRPEGAF-------------------------------------------------------AAAKGSPEAIIRL 359
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 634 CRSETVPKNfPQELRSYTV--QGFRVIALAHKTLKmgnlseVEHLAREKVESELTFLGLLIMENRLKKETKLVLKELSEA 711
Cdd:cd07538  360 CRLNPDEKA-AIEDAVSEMagEGLRVLAVAACRID------ESFLPDDLEDAVFIFVGLIGLADPLREDVPEAVRICCEA 432
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 712 RIRTVMITGDNLQTAITVAK-----NSEMIPPGSQviIVEADEPEefvpasvtwqlvenqetgpgkkeiymhtgnsstpr 786
Cdd:cd07538  433 GIRVVMITGDNPATAKAIAKqigldNTDNVITGQE--LDAMSDEE----------------------------------- 475
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 787 geggscyhfamsgksyqvifqhfnslLPKILVNGTVFARMSPGQKSSLIEEFQKLNYYVGMCGDGANDCGALKAAHAGIS 866
Cdd:cd07538  476 --------------------------LAEKVRDVNIFARVVPEQKLRIVQAFKANGEIVAMTGDGVNDAPALKAAHIGIA 529

                 ....*....
gi 767926595 867 LSEQEASVA 875
Cdd:cd07538  530 MGKRGTDVA 538
E1-E2_ATPase pfam00122
E1-E2 ATPase;
260-464 6.77e-33

E1-E2 ATPase;


Pssm-ID: 425475 [Multi-domain]  Cd Length: 181  Bit Score: 125.38  E-value: 6.77e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595  260 NKVQVtiiVKDKGLEELESRLLVPGDILILPGKFSLPCDAVLIDGSCVVNEGMLTGESIPVTKTplpqmentmpwkchsl 339
Cdd:pfam00122   5 PTATV---LRDGTEEEVPADELVPGDIVLLKPGERVPADGRIVEGSASVDESLLTGESLPVEKK---------------- 65
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595  340 edyRKHVLFCGTEVIqvkpsgQGPVRAVVLQTGYNTAKGDLVRSILYPRPLNFKLYSDAFKFIVFLACLGVMGFFYALGV 419
Cdd:pfam00122  66 ---KGDMVYSGTVVV------SGSAKAVVTATGEDTELGRIARLVEEAKSKKTPLQRLLDRLGKYFSPVVLLIALAVFLL 136
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 767926595  420 YMYHGVPPKDTVTMALILLTVTVPPVLPAALTIGNVYAQKRLKKK 464
Cdd:pfam00122 137 WLFVGGPPLRALLRALAVLVAACPCALPLATPLALAVGARRLAKK 181
P-type_ATPase cd02609
uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized ...
170-922 2.53e-32

uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized Streptococcus pneumoniae exported protein 7, Exp7; This subfamily contains P-type ATPase transporters of unknown function, similar to Streptococcus pneumoniae Exp7. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319795 [Multi-domain]  Cd Length: 661  Bit Score: 134.33  E-value: 2.53e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 170 GLTSEEQEVRRLVCGPNAIEVE-IQPIWKLLVKQVLNPF-YVFQAFTLTLWLSQGYIE--YSVAIIILTVISIVlsvydl 245
Cdd:cd02609    1 GLTTKEVEERQAEGKVNDQVEPvSRSVWQIVRENVFTLFnLINFVIAVLLILVGSYSNlaFLGVIIVNTVIGIV------ 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 246 rqQSVKLHNLVEDHN-----KVQVtiiVKDKGLEELESRLLVPGDILIL-PGKfSLPCDAVLIDGSCV-VNEGMLTGESI 318
Cdd:cd02609   75 --QEIRAKRQLDKLSilnapKVTV---IRDGQEVKIPPEELVLDDILILkPGE-QIPADGEVVEGGGLeVDESLLTGESD 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 319 PVTKTPLPQmentmpwkchsledyrkhvLFCGTEVIqvkpSGQGpvRAVVLQTG--------------YNTAKGDLVRSI 384
Cdd:cd02609  149 LIPKKAGDK-------------------LLSGSFVV----SGAA--YARVTAVGaesyaakltleakkHKLINSELLNSI 203
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 385 lyprplNfKLysdaFKFIVFLAC-LGVMGFFYAlgvYMYHGVPPKDTVTMA-----------LILLTVTvppvlpaALTI 452
Cdd:cd02609  204 ------N-KI----LKFTSFIIIpLGLLLFVEA---LFRRGGGWRQAVVSTvaallgmipegLVLLTSV-------ALAV 262
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 453 GNVyaqkRLKKKKIFCISPQRINMCGQINLVCFDKTGTLTEDGLDLWGTVPTADNCFQEAHSFASGqavpwspLCAAMAS 532
Cdd:cd02609  263 GAI----RLAKKKVLVQELYSIETLARVDVLCLDKTGTITEGKMKVERVEPLDEANEAEAAAALAA-------FVAASED 331
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 533 ChslillNGTIQGdpLDLKMFEGTAWkmedcivdsckfgtsvsniikpgpkasksPVEAIItlcqfPFSSSlQRMSVIAQ 612
Cdd:cd02609  332 N------NATMQA--IRAAFFGNNRF-----------------------------EVTSII-----PFSSA-RKWSAVEF 368
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 613 LAGENhfhvYMKGAPEMVARfcrseTVPKNFPQELRSYTVQGFRVIALAhktlkmGNLSEVEHlarEKVESELTFLGLLI 692
Cdd:cd02609  369 RDGGT----WVLGAPEVLLG-----DLPSEVLSRVNELAAQGYRVLLLA------RSAGALTH---EQLPVGLEPLALIL 430
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 693 MENRLKKETKLVLKELSEARIRTVMITGDNLQTAITVAKNSEmIPPGSQVIIVEADEPEEFVPasvtwQLVENQetgpgk 772
Cdd:cd02609  431 LTDPIRPEAKETLAYFAEQGVAVKVISGDNPVTVSAIAKRAG-LEGAESYIDASTLTTDEELA-----EAVENY------ 498
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 773 keiymhtgnsstprgeggscyhfamsgksyqvifqhfnsllpkilvngTVFARMSPGQKSSLIEEFQKLNYYVGMCGDGA 852
Cdd:cd02609  499 ------------------------------------------------TVFGRVTPEQKRQLVQALQALGHTVAMTGDGV 530
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 853 NDCGALKAAHAGISLSEqeasvASPFTSKTTNI-------QCVPHLIREGRAAL-----VSSfgVFKYLTMYGII-QFIS 919
Cdd:cd02609  531 NDVLALKEADCSIAMAS-----GSDATRQVAQVvlldsdfSALPDVVFEGRRVVnnierVAS--LFLVKTIYSVLlALIC 603

                 ...
gi 767926595 920 ALL 922
Cdd:cd02609  604 VIT 606
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
170-866 4.02e-30

magnesium-transporting P-type ATPase MgtA;


Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 128.65  E-value: 4.02e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 170 GLTSEEQEVRRLVCGPNAIEVEiQPI--WKLLVKQVLNPFYVFqaftLTLWlsqGYIEY-------SVAIIILTVISIVL 240
Cdd:PRK10517  67 GLNEAEVESAREQHGENELPAQ-KPLpwWVHLWVCYRNPFNIL----LTIL---GAISYatedlfaAGVIALMVAISTLL 138
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 241 S-VYDLR--QQSVKLHNLVEdhNKVQVTIIVKDKG---LEELESRLLVPGDILILPGKFSLPCDA-VLIDGSCVVNEGML 313
Cdd:PRK10517 139 NfIQEARstKAADALKAMVS--NTATVLRVINDKGengWLEIPIDQLVPGDIIKLAAGDMIPADLrILQARDLFVAQASL 216
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 314 TGESIPVTKTPLP-QMENTMPWKCHSLedyrkhvLFCGTEVIqvkpsgQGPVRAVVLQTGYNTAKGDLV-RSILYPRPLN 391
Cdd:PRK10517 217 TGESLPVEKFATTrQPEHSNPLECDTL-------CFMGTNVV------SGTAQAVVIATGANTWFGQLAgRVSEQDSEPN 283
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 392 fklysdAFKF---------IVFLAclgVMgffyALGVYMYHGVPPKDTVTMALILLTVTV---PPVLP----AALTIGNV 455
Cdd:PRK10517 284 ------AFQQgisrvswllIRFML---VM----APVVLLINGYTKGDWWEAALFALSVAVgltPEMLPmivtSTLARGAV 350
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 456 YaqkrLKKKKIFCISPQRINMCGQINLVCFDKTGTLTEDGLdlwgtvptadncFQEAHSFASGQAVPWSPLCAAMASCHS 535
Cdd:PRK10517 351 K----LSKQKVIVKRLDAIQNFGAMDILCTDKTGTLTQDKI------------VLENHTDISGKTSERVLHSAWLNSHYQ 414
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 536 LILLN----GTIQGDPLDLKMFEGTAWKMEDCIvdsckfgtsvsniikpgpkaskspveaiitlcqfPFSSSLQRMSVIa 611
Cdd:PRK10517 415 TGLKNlldtAVLEGVDEESARSLASRWQKIDEI----------------------------------PFDFERRRMSVV- 459
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 612 qLAGENHFH-VYMKGAPEMVARFCR-----SETVPKNfPQELR-------SYTVQGFRVIALAHKTLK--MGNLSEVEhl 676
Cdd:PRK10517 460 -VAENTEHHqLICKGALEEILNVCSqvrhnGEIVPLD-DIMLRrikrvtdTLNRQGLRVVAVATKYLParEGDYQRAD-- 535
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 677 arekvESELTFLGLLIMENRLKKETKLVLKELSEARIRTVMITGDNlqtaitvaknsemippgsqviiveadepeEFVPA 756
Cdd:PRK10517 536 -----ESDLILEGYIAFLDPPKETTAPALKALKASGVTVKILTGDS-----------------------------ELVAA 581
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 757 SVTwqlvenQETGPGKKEIYMhtgnsstprgegGScyhfamsgksyqVIFQHFNSLLPKILVNGTVFARMSPGQKSSLIE 836
Cdd:PRK10517 582 KVC------HEVGLDAGEVLI------------GS------------DIETLSDDELANLAERTTLFARLTPMHKERIVT 631
                        730       740       750
                 ....*....|....*....|....*....|
gi 767926595 837 EFQKLNYYVGMCGDGANDCGALKAAHAGIS 866
Cdd:PRK10517 632 LLKREGHVVGFMGDGINDAPALRAADIGIS 661
P-type_ATPase_SERCA cd02083
sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; ...
170-867 1.67e-28

sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; SERCA is a transmembrane (Ca2+)-ATPase and a major regulator of Ca(2+) homeostasis and contractility in cardiac and skeletal muscle. It re-sequesters cytoplasmic Ca(2+) to the sarco/endoplasmic reticulum store, thereby also terminating Ca(2+)-induced signaling such as in muscle contraction. Three genes (ATP2A1-3/SERCA1-3) encode SERCA pumps in mammals, further isoforms exist due to alternative splicing of transcripts. The activity of SERCA is regulated by two small membrane proteins called phospholamban and sarcolipin. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319778 [Multi-domain]  Cd Length: 979  Bit Score: 123.56  E-value: 1.67e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 170 GLTSEEQEVRRLVCGPNAIEVEI-QPIWKLLVKQvlnpfyvFQ-------------AFTLTL------WLSqGYIEYSVA 229
Cdd:cd02083   19 GLSDEQVKRRREKYGPNELPAEEgKSLWELVLEQ-------FDdllvrilllaaiiSFVLALfeegeeGVT-AFVEPFVI 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 230 IIILTVISIVLSVYDLRQQSV--KLHNLVEDHNKVqvtiIVKDKGLEELESRLLVPGDILILPGKFSLPCDAVLID---G 304
Cdd:cd02083   91 LLILIANAVVGVWQERNAEKAieALKEYEPEMAKV----LRNGKGVQRIRARELVPGDIVEVAVGDKVPADIRIIEiksT 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 305 SCVVNEGMLTGESIPVTKT----PLPQMENtmpwkchslEDyRKHVLFCGTEViqvkpsGQGPVRAVVLQTGYNTAKGDL 380
Cdd:cd02083  167 TLRVDQSILTGESVSVIKHtdvvPDPRAVN---------QD-KKNMLFSGTNV------AAGKARGVVVGTGLNTEIGKI 230
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 381 VRSILY----PRPLNFKLysDAF-----KFIvFLACLGV----MGFFY--ALG-------VYMYhgvppKDTVTMALill 438
Cdd:cd02083  231 RDEMAEteeeKTPLQQKL--DEFgeqlsKVI-SVICVAVwainIGHFNdpAHGgswikgaIYYF-----KIAVALAV--- 299
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 439 tVTVPPVLPAALTIGNVYAQKRLKKKKIFCISPQRINMCGQINLVCFDKTGTLT---------------EDGLDLW---- 499
Cdd:cd02083  300 -AAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTtnqmsvsrmfildkvEDDSSLNefev 378
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 500 --------GTVPTADNCFQEAHSfasgQAVPWSPLCAAMasCH-SLILLNGTIQ-----GDPLDlkmfegTAWKmedCIV 565
Cdd:cd02083  379 tgstyapeGEVFKNGKKVKAGQY----DGLVELATICAL--CNdSSLDYNESKGvyekvGEATE------TALT---VLV 443
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 566 DscKFGtsVSNIIKPGPKASKSPVeAIITLCQ--------FPFSSSLQRMSVIAQ-LAGENHFHVYMKGAPEMVARFCRS 636
Cdd:cd02083  444 E--KMN--VFNTDKSGLSKRERAN-ACNDVIEqlwkkeftLEFSRDRKSMSVYCSpTKASGGNKLFVKGAPEGVLERCTH 518
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 637 ETVPKN----FPQELR--------SYTVQGFRVIALAHKTLKMGNLSEVEHLARE--KVESELTFLGLLIMENRLKKETK 702
Cdd:cd02083  519 VRVGGGkvvpLTAAIKililkkvwGYGTDTLRCLALATKDTPPKPEDMDLEDSTKfyKYETDLTFVGVVGMLDPPRPEVR 598
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 703 LVLKELSEARIRTVMITGDNLQTAITVAKnsemippgsQVIIVEADEPeefvpasvtwqlvenqetgpgkkeiymhtgns 782
Cdd:cd02083  599 DSIEKCRDAGIRVIVITGDNKGTAEAICR---------RIGIFGEDED-------------------------------- 637
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 783 stprgeggscyhfaMSGKSYQVifQHFNSLLP---KILV-NGTVFARMSPGQKSSLIEEFQKLNYYVGMCGDGANDCGAL 858
Cdd:cd02083  638 --------------TTGKSYTG--REFDDLSPeeqREACrRARLFSRVEPSHKSKIVELLQSQGEITAMTGDGVNDAPAL 701

                 ....*....
gi 767926595 859 KAAHAGISL 867
Cdd:cd02083  702 KKAEIGIAM 710
ATPase-IIC_X-K TIGR01106
sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This ...
142-867 5.94e-25

sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This model describes the P-type ATPases responsible for the exchange of either protons or sodium ions for potassium ions across the plasma membranes of eukaryotes. Unlike most other P-type ATPases, members of this subfamily require a beta subunit for activity. This model encompasses eukaryotes and consists of two functional types, a Na/K antiporter found widely distributed in eukaryotes and a H/K antiporter found only in vertebrates. The Na+ or H+/K+ antiporter P-type ATPases have been characterized as Type IIC based on a published phylogenetic analysis. Sequences from Blastocladiella emersonii (GP|6636502, GP|6636502 and PIR|T43025), C. elegans (GP|2315419, GP|6671808 and PIR|T31763) and Drosophila melanogaster (GP|7291424) score below trusted cutoff, apparently due to long branch length (excessive divergence from the last common ancestor) as evidenced by a phylogenetic tree. Experimental evidence is needed to determine whether these sequences represent ATPases with conserved function. Aside from fragments, other sequences between trusted and noise appear to be bacterial ATPases of unclear lineage, but most likely calcium pumps. [Energy metabolism, ATP-proton motive force interconversion]


Pssm-ID: 273445 [Multi-domain]  Cd Length: 997  Bit Score: 112.19  E-value: 5.94e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595  142 NDLEKRFQKVGLLEDSNSCSDIHQTFGL----GLTSEEQEVRRLVCGPNAIEVEIQ-PIWKLLVKQVlnpfyvFQAFTLT 216
Cdd:TIGR01106   4 RDLDELKKEVEMDDHKLSLDELERKYGTdlskGLSAARAAEILARDGPNALTPPPTtPEWVKFCRQL------FGGFSML 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595  217 LWLSQ--GYIEYSVAI--------------IILTVISIVLSVYDLRQQSvKLHNLVEDHNKV--QVTIIVKDKGLEELES 278
Cdd:TIGR01106  78 LWIGAilCFLAYGIQAsteeepqndnlylgVVLSAVVIITGCFSYYQEA-KSSKIMESFKNMvpQQALVIRDGEKMSINA 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595  279 RLLVPGDILILPGKFSLPCDAVLIDG-SCVVNEGMLTGESIPVTKTPLPQMENtmpwkchSLEDyrKHVLFCGTEVIQvk 357
Cdd:TIGR01106 157 EQVVVGDLVEVKGGDRIPADLRIISAqGCKVDNSSLTGESEPQTRSPEFTHEN-------PLET--RNIAFFSTNCVE-- 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595  358 psgqGPVRAVVLQTGYNTAKGDL--VRSILYPRPLNFKLYSDAFKFIV--FLACLGVMGFFYALgVYMYHGVppkDTVTM 433
Cdd:TIGR01106 226 ----GTARGIVVNTGDRTVMGRIasLASGLENGKTPIAIEIEHFIHIItgVAVFLGVSFFILSL-ILGYTWL---EAVIF 297
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595  434 ALILLTVTVPPVLPAALTIGNVYAQKRLKKKKIFCISPQRINMCGQINLVCFDKTGTLTEDGLD---LWgtvptADNCFQ 510
Cdd:TIGR01106 298 LIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTvahMW-----FDNQIH 372
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595  511 EAHSFA--SGQAV-----PWSPLCAAMASCHSLILLNGTiQGDPLDLKMFEGTAWK--MEDCIVDSCKfgtSVSNIIKPG 581
Cdd:TIGR01106 373 EADTTEdqSGVSFdkssaTWLALSRIAGLCNRAVFKAGQ-ENVPILKRAVAGDASEsaLLKCIELCLG---SVMEMRERN 448
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595  582 PKaskspveaiitLCQFPFSSSLQRMSVIAQL--AGENHFHVYMKGAPEMVARFCRS-----------ETVPKNFPQELR 648
Cdd:TIGR01106 449 PK-----------VVEIPFNSTNKYQLSIHENedPRDPRHLLVMKGAPERILERCSSilihgkeqpldEELKEAFQNAYL 517
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595  649 SYTVQGFRVIALAHKTLKMGNLSEVEHLAREKVE---SELTFLGLLIMENRLKKETKLVLKELSEARIRTVMITGDNLQT 725
Cdd:TIGR01106 518 ELGGLGERVLGFCHLYLPDEQFPEGFQFDTDDVNfptDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPIT 597
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595  726 AITVAKnsemippgSQVIIVEADEPEEFVPASVTWQLvenqetgpgkkeiymhtgnSSTPRGEGGSCYHFAMSGKSYQvi 805
Cdd:TIGR01106 598 AKAIAK--------GVGIISEGNETVEDIAARLNIPV-------------------SQVNPRDAKACVVHGSDLKDMT-- 648
                         730       740       750       760       770       780
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767926595  806 fqhfNSLLPKILVNGT--VFARMSPGQKSSLIEEFQKLNYYVGMCGDGANDCGALKAAHAGISL 867
Cdd:TIGR01106 649 ----SEQLDEILKYHTeiVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAM 708
ATPase-IB_hvy TIGR01525
heavy metal translocating P-type ATPase; This model encompasses two equivalog models for the ...
225-869 4.48e-24

heavy metal translocating P-type ATPase; This model encompasses two equivalog models for the copper and cadmium-type heavy metal transporting P-type ATPases (TIGR01511 and TIGR01512) as well as those species which score ambiguously between both models. For more comments and references, see the files on TIGR01511 and 01512.


Pssm-ID: 273669 [Multi-domain]  Cd Length: 558  Bit Score: 107.72  E-value: 4.48e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595  225 EYSVAIIILTVISI--VLSVYDLRQQSVKLHNLVEdHNKVQVTIIVKDKGLEELESRLLVPGDILIL-PGKfSLPCDAVL 301
Cdd:TIGR01525  17 LVLEGALLLFLFLLgeTLEERAKSRASDALSALLA-LAPSTARVLQGDGSEEEVPVEELQVGDIVIVrPGE-RIPVDGVV 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595  302 IDGSCVVNEGMLTGESIPVTKTPlpqmentmpwkchsledyrkhvlfcGTEVIQVKPSGQGPVRAVVLQTGYNTAKGDLV 381
Cdd:TIGR01525  95 ISGESEVDESALTGESMPVEKKE-------------------------GDEVFAGTINGDGSLTIRVTKLGEDSTLAQIV 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595  382 RSI--LYPRPLNFKLYSDAFKFIVFLACLGVMGFFYALGvyMYHGVPPKDTVTMALILLTVTVPPVLPAALTIGNVYAQK 459
Cdd:TIGR01525 150 ELVeeAQSSKAPIQRLADRIASYYVPAVLAIALLTFVVW--LALGALWREALYRALTVLVVACPCALGLATPVAILVAIG 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595  460 RLKKKKIFCISPQRINMCGQINLVCFDKTGTLTEDGLDLWGTVPTADNCFQEAHSFASgqavpwsplCAAMASCHslill 539
Cdd:TIGR01525 228 AAARRGILIKGGDALEKLAKVKTVVFDKTGTLTTGKPTVVDIEPLDDASEEELLALAA---------ALEQSSSH----- 293
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595  540 ngtiqgdPLdlkmfeGTAwkmedcIVDSCKfgtsVSNIIKPGPKaskspVEAIITlcqfpfssslqrMSVIAQLAGEnhf 619
Cdd:TIGR01525 294 -------PL------ARA------IVRYAK----ERGLELPPED-----VEEVPG------------KGVEATVDGG--- 330
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595  620 HVYMKGAPEMVARFCRSETVPKNFPQELRSYTVQGFRVIALAhktlkmgnlsevehlarekVESELtfLGLLIMENRLKK 699
Cdd:TIGR01525 331 REVRIGNPRFLGNRELAIEPISASPDLLNEGESQGKTVVFVA-------------------VDGEL--LGVIALRDQLRP 389
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595  700 ETKLVLKELSEA-RIRTVMITGDNLQTAITVAKnsemippgsQVIIveADEpeefvpasvtwqlvenqetgpgkkeiymh 778
Cdd:TIGR01525 390 EAKEAIAALKRAgGIKLVMLTGDNRSAAEAVAA---------ELGI--DDE----------------------------- 429
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595  779 tgnsstprgeggscyhfamsgksyqvifqhfnsllpkilvngtVFARMSPGQKSSLIEEFQKLNYYVGMCGDGANDCGAL 858
Cdd:TIGR01525 430 -------------------------------------------VHAELLPEDKLAIVKKLQEEGGPVAMVGDGINDAPAL 466
                         650
                  ....*....|.
gi 767926595  859 KAAHAGISLSE 869
Cdd:TIGR01525 467 AAADVGIAMGS 477
P-type_ATPase_HM cd02079
P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) ...
209-876 8.98e-22

P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. These ATPases include mammalian copper-transporting ATPases, ATP7A and ATP7B, Bacillus subtilis CadA which transports cadmium, zinc and cobalt out of the cell, Bacillus subtilis ZosA/PfeT which transports copper, and perhaps also zinc and ferrous iron, Archaeoglobus fulgidus CopA and CopB, Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase, and Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+). The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This family belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319774 [Multi-domain]  Cd Length: 617  Bit Score: 100.75  E-value: 8.98e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 209 VFQAFTLTLWLSQ----GYIEYSVAIIILTVISIVLSVYDLRQQSVKLHNLVEdhNKVQVTIIVKDKGLEELESRLLVPG 284
Cdd:cd02079   69 AIGAFVASLLTPLlggiGYFEEAAMLLFLFLLGRYLEERARSRARSALKALLS--LAPETATVLEDGSTEEVPVDDLKVG 146
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 285 D-ILILPGKfSLPCDAVLIDGSCVVNEGMLTGESIPVTKTPlpqmentmpwkchsledyrkhvlfcGTEViqvkPSG--- 360
Cdd:cd02079  147 DvVLVKPGE-RIPVDGVVVSGESSVDESSLTGESLPVEKGA-------------------------GDTV----FAGtin 196
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 361 -QGPVRAVVLQTGYNTAKG---DLVRSILYPRPLNFKL---YSDAFKFIVFLACLGVMGFFYALGVymyhgvPPKDTVTM 433
Cdd:cd02079  197 lNGPLTIEVTKTGEDTTLAkiiRLVEEAQSSKPPLQRLadrFARYFTPAVLVLAALVFLFWPLVGG------PPSLALYR 270
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 434 ALILLTVTVPPVL----PAALTIGNVYAQKR---LKKKKIFcispQRInmcGQINLVCFDKTGTLTEDGLDLWGTVPTAD 506
Cdd:cd02079  271 ALAVLVVACPCALglatPTAIVAGIGRAARKgilIKGGDVL----ETL---AKVDTVAFDKTGTLTEGKPEVTEIEPLEG 343
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 507 ncFQEAHSFAsgqavpwspLCAAMA--SCHslillngtiqgdPLdlkmfeGTAwkmedcIVDSCKfgtsvsniikpGPKA 584
Cdd:cd02079  344 --FSEDELLA---------LAAALEqhSEH------------PL------ARA------IVEAAE-----------EKGL 377
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 585 SKSPVEAIITlcqFPfssslqRMSVIAQLAGenhfHVYMKGAPEMVARFCRSETvpknfpqelrsytvqgfrvialAHKT 664
Cdd:cd02079  378 PPLEVEDVEE---IP------GKGISGEVDG----REVLIGSLSFAEEEGLVEA----------------------ADAL 422
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 665 LKMGNLSEVeHLAREKveselTFLGLLIMENRLKKETKLVLKELSEARIRTVMITGDNLQTAITVAKnsemippgsQVII 744
Cdd:cd02079  423 SDAGKTSAV-YVGRDG-----KLVGLFALEDQLRPEAKEVIAELKSGGIKVVMLTGDNEAAAQAVAK---------ELGI 487
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 745 VEadepeefvpasvtwqlvenqetgpgkkeiymhtgnsstprgeggscyhfamsgksyqvifqhfnsllpkilvngtVFA 824
Cdd:cd02079  488 DE---------------------------------------------------------------------------VHA 492
                        650       660       670       680       690
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767926595 825 RMSPGQKSSLIEEFQKLNYYVGMCGDGANDCGALKAAHAGISLSEQEAsVAS 876
Cdd:cd02079  493 GLLPEDKLAIVKALQAEGGPVAMVGDGINDAPALAQADVGIAMGSGTD-VAI 543
P-type_ATPase_APLT cd07536
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
598-879 1.23e-20

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, Neo1p, and human ATP8A2, -9B, -10D, -11B, and -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. Mammalian ATP11C may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. The yeast Neo1p localizes to the endoplasmic reticulum and the Golgi complex and plays a role in membrane trafficking within the endomembrane system. Human putative ATPase phospholipid transporting 9B, ATP9B, localizes to the trans-golgi network in a CDC50 protein-independent manner. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319838 [Multi-domain]  Cd Length: 805  Bit Score: 98.06  E-value: 1.23e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 598 FPFSSSLQRMSVIAQLAGENHFHVYMKGAPEMVARFCRSETVPKNFPQELRSYTVQGFRVIALAHKTL------------ 665
Cdd:cd07536  397 LEFTSDRKRMSVIVRDESTGEITLYMKGADVAISPIVSKDSYMEQYNDWLEEECGEGLRTLCVAKKALteneyqewesry 476
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 666 KMGNLSEVEHLAR-----EKVESELTFLGLLIMENRLKKETKLVLKELSEARIRTVMITGDNLQTAITVAKNSEMIPPGS 740
Cdd:cd07536  477 TEASLSLHDRSLRvaevvESLERELELLGLTAIEDRLQAGVPETIETLRKAGIKIWMLTGDKQETAICIAKSCHLVSRTQ 556
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 741 QVIIVEADEPEEfVPASVTWQLVENQETGPGKKEIymhtgnsstprgeggscyHFAMSGKSYQVIFQHFNS--LLPKILV 818
Cdd:cd07536  557 DIHLLRQDTSRG-ERAAITQHAHLELNAFRRKHDV------------------ALVIDGDSLEVALKYYRHefVELACQC 617
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767926595 819 NGTVFARMSPGQKSSLIEEFQKLNYYVGMC-GDGANDCGALKAAHAGISLSEQE---ASVASPFT 879
Cdd:cd07536  618 PAVICCRVSPTQKARIVTLLKQHTGRRTLAiGDGGNDVSMIQAADCGVGISGKEgkqASLAADYS 682
PRK15122 PRK15122
magnesium-transporting ATPase; Provisional
170-866 5.58e-20

magnesium-transporting ATPase; Provisional


Pssm-ID: 237914 [Multi-domain]  Cd Length: 903  Bit Score: 95.86  E-value: 5.58e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 170 GLTSEEQEVRRLVCGPNAIEVEIQPIWKL-LVKQVLNPF-YVFQA-----FTLTLWLSQGYIE---YSVAIIILTVISI- 238
Cdd:PRK15122  45 GLTEEDAAERLQRYGPNEVAHEKPPHALVqLLQAFNNPFiYVLMVlaaisFFTDYWLPLRRGEetdLTGVIIILTMVLLs 124
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 239 -VLSV---YDLRQQSVKLHNLVedhnKVQVTIIVKDKG-----LEELESRLLVPGDILILPGKFSLPCDAVLIDG-SCVV 308
Cdd:PRK15122 125 gLLRFwqeFRSNKAAEALKAMV----RTTATVLRRGHAgaepvRREIPMRELVPGDIVHLSAGDMIPADVRLIESrDLFI 200
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 309 NEGMLTGESIPVTK-----TPLPQMENTMPWKCHSLEDyRKHVLFCGTEVIQvkpsgqGPVRAVVLQTGYNTAKGDLVRS 383
Cdd:PRK15122 201 SQAVLTGEALPVEKydtlgAVAGKSADALADDEGSLLD-LPNICFMGTNVVS------GTATAVVVATGSRTYFGSLAKS 273
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 384 ILYPRP-------LNfklySDAFKFIVFLAclgVMgffyALGVYMYHGVPPKDTVTMALILLTVTV---PPVLP----AA 449
Cdd:PRK15122 274 IVGTRAqtafdrgVN----SVSWLLIRFML---VM----VPVVLLINGFTKGDWLEALLFALAVAVgltPEMLPmivsSN 342
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 450 LTIGNVYAQKRlkkKKIFcispQRINMC---GQINLVCFDKTGTLTEDGLDLwgtvptadncfqEAHSFASGQAVPwspl 526
Cdd:PRK15122 343 LAKGAIAMARR---KVVV----KRLNAIqnfGAMDVLCTDKTGTLTQDRIIL------------EHHLDVSGRKDE---- 399
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 527 caamaSCHSLILLNGTIQGDPLDLkmfegtawkMEDCIVdscKFGTSVSNIIKPgpkASKSPVEaiitlcQFPFSSSLQR 606
Cdd:PRK15122 400 -----RVLQLAWLNSFHQSGMKNL---------MDQAVV---AFAEGNPEIVKP---AGYRKVD------ELPFDFVRRR 453
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 607 MSVIAQLAGENHFHVyMKGA-PEMVA----------RFCRSETVPKNFPQELRSYTVQGFRVIALAHKTLKMGNLSEVEH 675
Cdd:PRK15122 454 LSVVVEDAQGQHLLI-CKGAvEEMLAvathvrdgdtVRPLDEARRERLLALAEAYNADGFRVLLVATREIPGGESRAQYS 532
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 676 LAREKvesELTFLGLLIMENRLKKETKLVLKELSEARIRTVMITGDNlqtAITVAKNSEmippgsQVIIveadEPEEFVp 755
Cdd:PRK15122 533 TADER---DLVIRGFLTFLDPPKESAAPAIAALRENGVAVKVLTGDN---PIVTAKICR------EVGL----EPGEPL- 595
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 756 asvtwqlvenqeTGPgkkEIYmhtgnsstprgeggscyhfAMSGKSYQVIFQHfnsllpkilvnGTVFARMSPGQKSSLI 835
Cdd:PRK15122 596 ------------LGT---EIE-------------------AMDDAALAREVEE-----------RTVFAKLTPLQKSRVL 630
                        730       740       750
                 ....*....|....*....|....*....|.
gi 767926595 836 EEFQKLNYYVGMCGDGANDCGALKAAHAGIS 866
Cdd:PRK15122 631 KALQANGHTVGFLGDGINDAPALRDADVGIS 661
ZntA COG2217
Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];
267-869 1.72e-19

Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];


Pssm-ID: 441819 [Multi-domain]  Cd Length: 717  Bit Score: 94.05  E-value: 1.72e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 267 IVKDKGLEELESRLLVPGD-ILILPGKfSLPCDAVLIDGSCVVNEGMLTGESIPVTKTPlpqmentmpwkchsledyrkh 345
Cdd:COG2217  217 VLRDGEEVEVPVEELRVGDrVLVRPGE-RIPVDGVVLEGESSVDESMLTGESLPVEKTP--------------------- 274
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 346 vlfcGTEVIqvkpSG----QGPVRAVVLQTGYNTAKGDLVRsilyprplnfkLYSDA-----------------FKFIVF 404
Cdd:COG2217  275 ----GDEVF----AGtinlDGSLRVRVTKVGSDTTLARIIR-----------LVEEAqsskapiqrladriaryFVPAVL 335
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 405 LACLGVMGFFYALgvymyhGVPPKDTVTMALILLTVTVPPVL----PAALTIGNvyaqKRLKKKKIFCISPQRINMCGQI 480
Cdd:COG2217  336 AIAALTFLVWLLF------GGDFSTALYRAVAVLVIACPCALglatPTAIMVGT----GRAARRGILIKGGEALERLAKV 405
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 481 NLVCFDKTGTLTEDGLDLWGTVPTADNCFQEAHSFAsgqavpwspLCAAMASCHslillngtiqgdPLdlkmfeGTAwkm 560
Cdd:COG2217  406 DTVVFDKTGTLTEGKPEVTDVVPLDGLDEDELLALA---------AALEQGSEH------------PL------ARA--- 455
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 561 edcIVDSCKfgtsvsniikpGPKASKSPVEAIitlcqfpfsSSLQRMSVIAQLAGenhfHVYMKGAPEMVARfcRSETVP 640
Cdd:COG2217  456 ---IVAAAK-----------ERGLELPEVEDF---------EAIPGKGVEATVDG----KRVLVGSPRLLEE--EGIDLP 506
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 641 KNFPQELRSYTVQGFRVIALAhktlkmgnlsevehlarekVESELtfLGLLIMENRLKKETKLVLKELSEARIRTVMITG 720
Cdd:COG2217  507 EALEERAEELEAEGKTVVYVA-------------------VDGRL--LGLIALADTLRPEAAEAIAALKALGIRVVMLTG 565
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 721 DNLQTAITVAKnsemippgsQVIIVEadepeefvpasvtwqlvenqetgpgkkeiymhtgnsstprgeggscyhfamsgk 800
Cdd:COG2217  566 DNERTAEAVAR---------ELGIDE------------------------------------------------------ 582
                        570       580       590       600       610       620
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767926595 801 syqvifqhfnsllpkilvngtVFARMSPGQKSSLIEEFQKLNYYVGMCGDGANDCGALKAAHAGISLSE 869
Cdd:COG2217  583 ---------------------VRAEVLPEDKAAAVRELQAQGKKVAMVGDGINDAPALAAADVGIAMGS 630
ATPase-Plipid TIGR01652
phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase ...
231-937 4.31e-19

phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase responsible for transporting phospholipids from one leaflet of bilayer membranes to the other. These ATPases are found only in eukaryotes.


Pssm-ID: 273734 [Multi-domain]  Cd Length: 1057  Bit Score: 93.21  E-value: 4.31e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595   231 IILTVISIVLSVYDLRQqsvklHNLVEDHNKVQVTIIVKDKGLEELESRLLVPGDILILPGKFSLPCDAVLI-----DGS 305
Cdd:TIGR01652   59 FVLIVTAIKEAIEDIRR-----RRRDKEVNNRLTEVLEGHGQFVEIPWKDLRVGDIVKVKKDERIPADLLLLsssepDGV 133
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595   306 CVVNEGMLTGE-------SIPVTKTPLPQ--MENTMPW-KC---HS----------LEDYRK------HVLFCGTEViqv 356
Cdd:TIGR01652  134 CYVETANLDGEtnlklrqALEETQKMLDEddIKNFSGEiECeqpNAslysfqgnmtINGDRQyplspdNILLRGCTL--- 210
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595   357 kpSGQGPVRAVVLQTGY------NTAKGDLVRSILyPRPLNFKLYsdafkfIVFLaCLGVMGFFYALGVYMYHGVPPKD- 429
Cdd:TIGR01652  211 --RNTDWVIGVVVYTGHdtklmrNATQAPSKRSRL-EKELNFLII------ILFC-LLFVLCLISSVGAGIWNDAHGKDl 280
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595   430 ------------------TVTMALILLTVTVPPVLPAALTIGN-VYAQKRLKKKKIFCISPQRINMC---------GQIN 481
Cdd:TIGR01652  281 wyirldvsernaaangffSFLTFLILFSSLIPISLYVSLELVKsVQAYFINSDLQMYHEKTDTPASVrtsnlneelGQVE 360
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595   482 LVCFDKTGTLTEDGLDL---------WGTVPTADNCF-QEAHS-----------------FASGQAV-------PWSPLC 527
Cdd:TIGR01652  361 YIFSDKTGTLTQNIMEFkkcsiagvsYGDGFTEIKDGiRERLGsyvenensmlveskgftFVDPRLVdllktnkPNAKRI 440
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595   528 ----AAMASCHSLILlngTIQGDPLDLKMFEGtAWKMEDCIVdscKFGTSVSNIIKPGPKASKSPVEAII-------TLC 596
Cdd:TIGR01652  441 neffLALALCHTVVP---EFNDDGPEEITYQA-ASPDEAALV---KAARDVGFVFFERTPKSISLLIEMHgetkeyeILN 513
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595   597 QFPFSSSLQRMSVIAQLAgENHFHVYMKGAPE-MVARFCR-SETVPKNFPQELRSYTVQGFRVIALAHKTLK-------- 666
Cdd:TIGR01652  514 VLEFNSDRKRMSVIVRNP-DGRIKLLCKGADTvIFKRLSSgGNQVNEETKEHLENYASEGLRTLCIAYRELSeeeyeewn 592
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595   667 ---------MGNLSEVEHLAREKVESELTFLGLLIMENRLKKETKLVLKELSEARIRTVMITGDNLQTAITVAKNSEMIP 737
Cdd:TIGR01652  593 eeyneastaLTDREEKLDVVAESIEKDLILLGATAIEDKLQEGVPETIELLRQAGIKIWVLTGDKVETAINIGYSCRLLS 672
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595   738 PGSQVIIVEAD--EPEEFVPASVTWQLVENQEtgpgkkeiymHTGNSSTPRGEG----GSCYHFAMSGKSYQVIFQhFNS 811
Cdd:TIGR01652  673 RNMEQIVITSDslDATRSVEAAIKFGLEGTSE----------EFNNLGDSGNVAlvidGKSLGYALDEELEKEFLQ-LAL 741
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595   812 LLPKILVngtvfARMSPGQKSSLIEEFQKLNYYVGMC-GDGANDCGALKAAHAGISLSEQE---ASVASPFTskttnIQC 887
Cdd:TIGR01652  742 KCKAVIC-----CRVSPSQKADVVRLVKKSTGKTTLAiGDGANDVSMIQEADVGVGISGKEgmqAVMASDFA-----IGQ 811
                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 767926595   888 VPHLIR----EG-----RAALVSSFGVFKYLTMYgIIQFISALLLYWQLQLFGNYQYLM 937
Cdd:TIGR01652  812 FRFLTKlllvHGrwsykRISKMILYFFYKNLIFA-IIQFWYSFYNGFSGQTLYEGWYMV 869
P-type_ATPase_APLT_Neo1-like cd07541
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human ...
598-879 8.76e-19

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as a flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. The yeast Neo1 gene is an essential gene; Neo1p localizes to the endoplasmic reticulum and the Golgi complex and plays a role in membrane trafficking within the endomembrane system. Also included in this sub family is human putative ATPase phospholipid transporting 9B, ATP9B, which localizes to the trans-golgi network in a CDC50 protein-independent manner. Levels of ATP9B, along with levels of other ATPase genes, may contribute to expressivity of and atypical presentations of Hailey-Hailey disease (HHD), and the ATP9B gene has recently been identified as a putative Alzheimer's disease loci. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319841 [Multi-domain]  Cd Length: 792  Bit Score: 91.70  E-value: 8.76e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 598 FPFSSSLQRMSVIAQLAGENHFHVYMKGAPEMVARFcrsetVPKNF--PQELRSYTVQGFRVIALAHKTL---------- 665
Cdd:cd07541  367 FPFTSESKRMGIIVREEKTGEITFYMKGADVVMSKI-----VQYNDwlEEECGNMAREGLRTLVVAKKKLseeeyqafek 441
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 666 -----KMGNLSEVEHLAR--EKVESELTFLGLLIMENRLKKETKLVLKELSEARIRTVMITGDNLQTAITVAKNSEMIPP 738
Cdd:cd07541  442 rynaaKLSIHDRDLKVAEvvESLERELELLCLTGVEDKLQEDVKPTLELLRNAGIKIWMLTGDKLETATCIAKSSKLVSR 521
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 739 GSQVIIVEAdepeefvpasvtwqlVENQEtgpgkkEIYMHTGNSstpRGEGGSCyhFAMSGKSYQVIFQHFNSLLPKILV 818
Cdd:cd07541  522 GQYIHVFRK---------------VTTRE------EAHLELNNL---RRKHDCA--LVIDGESLEVCLKYYEHEFIELAC 575
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767926595 819 NGT--VFARMSPGQKSS---LIEEFQKLNyyVGMCGDGANDCGALKAAHAGISLSEQE---ASVASPFT 879
Cdd:cd07541  576 QLPavVCCRCSPTQKAQivrLIQKHTGKR--TCAIGDGGNDVSMIQAADVGVGIEGKEgkqASLAADFS 642
ATPase-IB1_Cu TIGR01511
copper-(or silver)-translocating P-type ATPase; This model describes the P-type ATPase ...
263-899 2.42e-18

copper-(or silver)-translocating P-type ATPase; This model describes the P-type ATPase primarily responsible for translocating copper ions accross biological membranes. These transporters are found in prokaryotes and eukaryotes. This model encompasses those species which pump copper ions out of cells or organelles (efflux pumps such as CopA of Escherichia coli) as well as those which pump the ion into cells or organelles either for the purpose of supporting life in extremely low-copper environments (for example CopA of Enterococcus hirae) or for the specific delivery of copper to a biological complex for which it is a necessary component (for example FixI of Bradyrhizobium japonicum, or CtaA and PacS of Synechocystis). The substrate specificity of these transporters may, to a varying degree, include silver ions (for example, CopA from Archaeoglobus fulgidus). Copper transporters from this family are well known as the genes which are mutated in two human disorders of copper metabolism, Wilson's and Menkes' diseases. The sequences contributing to the seed of this model are all experimentally characterized. The copper P-type ATPases have been characterized as Type IB based on a phylogenetic analysis which combines the copper-translocating ATPases with the cadmium-translocating species. This model and that describing the cadmium-ATPases (TIGR01512) are well separated, and thus we further type the copper-ATPases as IB1 (and the cadmium-ATPases as IB2). Several sequences which have not been characterized experimentally fall just below the cutoffs for both of these models (SP|Q9CCL1 from Mycobacterium leprae, GP|13816263 from Sulfolobus solfataricus, OMNI|NTL01CJ01098 from Campylobacter jejuni, OMNI|NTL01HS01687 from Halobacterium sp., GP|6899169 from Ureaplasma urealyticum and OMNI|HP1503 from Helicobacter pylori). Accession PIR|A29576 from Enterococcus faecalis scores very high against this model, but yet is annotated as an "H+/K+ exchanging ATPase". BLAST of this sequence does not hit anything else annotated in this way. This error may come from the characterization paper published in 1987. Accession GP|7415611 from Saccharomyces cerevisiae appears to be mis-annotated as a cadmium resistance protein. Accession OMNI|NTL01HS00542 from Halobacterium which scores above trusted for this model is annotated as "molybdenum-binding protein" although no evidence can be found for this classification. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273664 [Multi-domain]  Cd Length: 562  Bit Score: 89.64  E-value: 2.42e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595  263 QVTIIVKDKGLEELESRLLVPGDIL-ILPGKfSLPCDAVLIDGSCVVNEGMLTGESIPVTKTplpqmentmpwkchsled 341
Cdd:TIGR01511  92 TATLLTKDGSIEEVPVALLQPGDIVkVLPGE-KIPVDGTVIEGESEVDESLVTGESLPVPKK------------------ 152
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595  342 yrkhvlfCGTEVIQVKPSGQGPVRAVVLQTGYNT-----------AKG---------DLVRSILYPrplnfklysdafkF 401
Cdd:TIGR01511 153 -------VGDPVIAGTVNGTGSLVVRATATGEDTtlaqivrlvrqAQQskapiqrlaDKVAGYFVP-------------V 212
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595  402 IVFLACLGVMGFFYALgvymyhgvppkdtvTMALILLTVTVPPVL----PAALTIGNVYAQKRlkkkKIFCISPQRINMC 477
Cdd:TIGR01511 213 VIAIALITFVIWLFAL--------------EFAVTVLIIACPCALglatPTVIAVATGLAAKN----GVLIKDGDALERA 274
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595  478 GQINLVCFDKTGTLTEDGLDLWGTVPTADNCFQEAHSFASGQAVPWS-PLCAAmaschslillngtiqgdpldlkmfegt 556
Cdd:TIGR01511 275 ANIDTVVFDKTGTLTQGKPTVTDVHVFGDRDRTELLALAAALEAGSEhPLAKA--------------------------- 327
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595  557 awkmedcIVDSCKfgtsvsniikpgpkaskspvEAIITLCQFPFSSSLQRMSVIAQLAGenhfHVYMKGAPemvaRFCRS 636
Cdd:TIGR01511 328 -------IVSYAK--------------------EKGITLVTVSDFKAIPGIGVEGTVEG----TKIQLGNE----KLLGE 372
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595  637 ETVPKNfPQELRSYTVqgfrVIALahktlkmgnlsevehlarekVESELTflGLLIMENRLKKETKLVLKELSEARIRTV 716
Cdd:TIGR01511 373 NAIKID-GKAGQGSTV----VLVA--------------------VNGELA--GVFALEDQLRPEAKEVIQALKRRGIEPV 425
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595  717 MITGDNLQTAITVAKnsemippgsQVIIveadepeefvpasvtwqlvenqetgpgkkeiymhtgnsstprgeggscyhfa 796
Cdd:TIGR01511 426 MLTGDNRKTAKAVAK---------ELGI---------------------------------------------------- 444
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595  797 msgksyqvifqhfnsllpkilvngTVFARMSPGQKSSLIEEFQKLNYYVGMCGDGANDCGALKAAHAGISLSE--QEASV 874
Cdd:TIGR01511 445 ------------------------DVRAEVLPDDKAALIKKLQEKGPVVAMVGDGINDAPALAQADVGIAIGAgtDVAIE 500
                         650       660
                  ....*....|....*....|....*
gi 767926595  875 ASPFTSKTTNIQCVPHLIREGRAAL 899
Cdd:TIGR01511 501 AADVVLLRNDLNDVATAIDLSRKTL 525
P-type_ATPase_Na-K_like cd02608
alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+) ...
170-867 4.39e-18

alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+)/K(+)-ATPase alpha subunits 1-4; This subfamily includes the alpha subunit of Na(+)/K(+)-ATPase a heteromeric transmembrane protein composed of an alpha- and beta-subunit and an optional third subunit belonging to the FXYD proteins which are more tissue specific regulatory subunits of the enzyme. The alpha-subunit is the catalytic subunit responsible for transport activities of the enzyme. This subfamily includes all four isotopes of the human alpha subunit: (alpha1-alpha4, encoded by the ATP1A1- ATP1A4 genes). Na(+)/K(+)-ATPase functions chiefly as an ion pump, hydrolyzing one molecule of ATP to pump three Na(+) out of the cell in exchange for two K(+)entering the cell per pump cycle. In addition Na(+)/K(+)-ATPase acts as a signal transducer. This subfamily also includes Oreochromis mossambicus (tilapia) Na(+)/K(+)-ATPase alpha 1 and alpha 3 subunits, and gastric H(+)/K(+)-ATPase which exchanges hydronium ion with potassium and is responsible for gastric acid secretion. Gastric H(+)/K(+)-ATPase is an alpha,beta-heterodimeric enzyme. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319794 [Multi-domain]  Cd Length: 905  Bit Score: 89.72  E-value: 4.39e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 170 GLTSEEQEVRRLVCGPNAIEVEIQ-PIWKLLVKQVlnpfyvFQAFTLTLWLSQ--GYIEYSVAI--------------II 232
Cdd:cd02608    1 GLTSARAAEILARDGPNALTPPPTtPEWVKFCKQL------FGGFSMLLWIGAilCFLAYGIQAateeepsndnlylgIV 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 233 LTVISIVLSVYDLRQQSvKLHNLVEDHNKV--QVTIIVKDKGLEELESRLLVPGDILILPGKFSLPCDAVLIDG-SCVVN 309
Cdd:cd02608   75 LAAVVIVTGCFSYYQEA-KSSKIMDSFKNMvpQQALVIRDGEKMQINAEELVVGDLVEVKGGDRIPADIRIISAhGCKVD 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 310 EGMLTGESIPVTKTPLPQMENtmpwkchSLEDyrKHVLFCGTEVIQvkpsgqGPVRAVVLQTGYNTAKGDL--VRSILYP 387
Cdd:cd02608  154 NSSLTGESEPQTRSPEFTHEN-------PLET--KNIAFFSTNCVE------GTARGIVINTGDRTVMGRIatLASGLEV 218
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 388 RPLNFKLYSDAF-KFIVFLAC-LGVMGFFYALgVYMYHgvpPKDTVTMALILLTVTVPPVLPAALTIGNVYAQKRLKKKK 465
Cdd:cd02608  219 GKTPIAREIEHFiHIITGVAVfLGVSFFILSL-ILGYT---WLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKN 294
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 466 IFCISPQRINMCGQINLVCFDKTGTLTEDGLD---LW--GTVPTADNCFQEAHSFASGQAVPWSPLCAAMASCHSLILLN 540
Cdd:cd02608  295 CLVKNLEAVETLGSTSTICSDKTGTLTQNRMTvahMWfdNQIHEADTTEDQSGASFDKSSATWLALSRIAGLCNRAEFKA 374
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 541 GTiQGDPLDLKMFEGTAwkMEDCIVDSCKFGT-SVSNIIKPGPKaskspveaiitLCQFPFSSSLQRMSVIAQLA--GEN 617
Cdd:cd02608  375 GQ-ENVPILKRDVNGDA--SESALLKCIELSCgSVMEMRERNPK-----------VAEIPFNSTNKYQLSIHENEdpGDP 440
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 618 HFHVYMKGAPEMVARFCRS-----------ETVPKNFPQ---ELRSYtvqGFRVIALAHKTLKMGNLSEVEHLAREKVE- 682
Cdd:cd02608  441 RYLLVMKGAPERILDRCSTilingkeqpldEEMKEAFQNaylELGGL---GERVLGFCHLYLPDDKFPEGFKFDTDEVNf 517
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 683 --SELTFLGLLIMENRLKKETKLVLKELSEARIRTVMITGDNLQTAITVAKnsemippgsQVIIVeadepeefvpasvtw 760
Cdd:cd02608  518 ptENLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAK---------GVGII--------------- 573
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 761 qlvenqetgpgkkeiymhtgnsstprgeggscyhfamsgksyqvifqhfnsllpkilvngtVFARMSPGQKSSLIEEFQK 840
Cdd:cd02608  574 -------------------------------------------------------------VFARTSPQQKLIIVEGCQR 592
                        730       740
                 ....*....|....*....|....*..
gi 767926595 841 LNYYVGMCGDGANDCGALKAAHAGISL 867
Cdd:cd02608  593 QGAIVAVTGDGVNDSPALKKADIGVAM 619
P-type_ATPase_Cu-like cd02094
P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A ...
266-865 4.15e-17

P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B; The mammalian copper-transporting P-type ATPases, ATP7A and ATP7B are key molecules required for the regulation and maintenance of copper homeostasis. Menkes and Wilson diseases are caused by mutation in ATP7A and ATP7B respectively. This subfamily includes other copper-transporting ATPases such as: Bacillus subtilis CopA , Archeaoglobus fulgidus CopA, and Saccharomyces cerevisiae Ccc2p. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319783 [Multi-domain]  Cd Length: 647  Bit Score: 85.99  E-value: 4.15e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 266 IIVKDKGLEELESRLLVPGDIL-ILPGKfSLPCDAVLIDGSCVVNEGMLTGESIPVTKTPlpqmentmpwkchsledyrk 344
Cdd:cd02094  142 RVIRDGKEVEVPIEEVQVGDIVrVRPGE-KIPVDGVVVEGESSVDESMLTGESLPVEKKP-------------------- 200
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 345 hvlfcGTEVIqvkpSG----QGPVRAVVLQTGYNT-----------AKG---------DLVRSILYPrplnfklysdafk 400
Cdd:cd02094  201 -----GDKVI----GGtingNGSLLVRATRVGADTtlaqiirlveeAQGskapiqrlaDRVSGVFVP------------- 258
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 401 FIVFLACLgvmgffyALGVYMYHGVPPKdtVTMALIlLTVTV-----PPVL----PAALTIGNvyaqKRLKKKKIFCISP 471
Cdd:cd02094  259 VVIAIAIL-------TFLVWLLLGPEPA--LTFALV-AAVAVlviacPCALglatPTAIMVGT----GRAAELGILIKGG 324
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 472 QRINMCGQINLVCFDKTGTLTEdgldlwGTvPTadncFQEAHSFASGQAVPWSPLCAAM--ASCHslillngtiqgdPLd 549
Cdd:cd02094  325 EALERAHKVDTVVFDKTGTLTE------GK-PE----VTDVVPLPGDDEDELLRLAASLeqGSEH------------PL- 380
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 550 lkmfeGTAwkmedcIVDSCKfgtsvsniikpgpkaskspvEAIITLCQFPFSSSLQRMSVIAQLAGenhfHVYMKGAPEM 629
Cdd:cd02094  381 -----AKA------IVAAAK--------------------EKGLELPEVEDFEAIPGKGVRGTVDG----RRVLVGNRRL 425
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 630 VARFcrsETVPKNFPQELRSYTVQGFRVIALAhktlkmgnlsevehlarekVESELtfLGLLIMENRLKKETKLVLKELS 709
Cdd:cd02094  426 MEEN---GIDLSALEAEALALEEEGKTVVLVA-------------------VDGEL--AGLIAVADPLKPDAAEAIEALK 481
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 710 EARIRTVMITGDNLQTAITVAKnsemippgsQVIIveaDEpeefvpasvtwqlvenqetgpgkkeiymhtgnsstprgeg 789
Cdd:cd02094  482 KMGIKVVMLTGDNRRTARAIAK---------ELGI---DE---------------------------------------- 509
                        570       580       590       600       610       620       630
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767926595 790 gscyhfamsgksyqvifqhfnsllpkilvngtVFARMSPGQKSSLIEEFQKLNYYVGMCGDGANDCGALKAAHAGI 865
Cdd:cd02094  510 --------------------------------VIAEVLPEDKAEKVKKLQAQGKKVAMVGDGINDAPALAQADVGI 553
P-type_ATPase_APLT_Dnf-like cd02073
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
478-878 7.43e-16

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. This subfamily includes mammalian flippases such as ATP11C which may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319770 [Multi-domain]  Cd Length: 836  Bit Score: 82.60  E-value: 7.43e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 478 GQINLVCFDKTGTLTEDgldlwgtVPTADNCFQEAHSFAsgqavpwspLCAAMASCHSLIllngtIQGDPLDLKMF---- 553
Cdd:cd02073  353 GQVEYIFSDKTGTLTEN-------IMEFKKCSINGVDYG---------FFLALALCHTVV-----PEKDDHPGQLVyqas 411
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 554 ---EG---TAWKMEDCIVDSCKFGTSVSNIiKPGPKASKspVEAIItlcqfPFSSSLQRMSVIAQlAGENHFHVYMKGAP 627
Cdd:cd02073  412 spdEAalvEAARDLGFVFLSRTPDTVTINA-LGEEEEYE--ILHIL-----EFNSDRKRMSVIVR-DPDGRILLYCKGAD 482
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 628 EMVARFCRSETvPKNFPQ---ELRSYTVQGFRVIALAHKTLK-----------------MGNLSEVEHLAREKVESELTF 687
Cdd:cd02073  483 SVIFERLSPSS-LELVEKtqeHLEDFASEGLRTLCLAYREISeeeyeewnekydeastaLQNREELLDEVAEEIEKDLIL 561
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 688 LGLLIMENRLKK---ETklvLKELSEARIRTVMITGDNLQTAITVAKNSEMIPPGSqviiveadepEEFVpasvtwqLVE 764
Cdd:cd02073  562 LGATAIEDKLQDgvpET---IEALQRAGIKIWVLTGDKQETAINIGYSCRLLSEDM----------ENLA-------LVI 621
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 765 NqetgpgkkeiymhtgnsstprgegGSCYHFAMSGKSyqviFQHFNSLLpkILVNGTVFARMSPGQKSSLIEEFQKLNYY 844
Cdd:cd02073  622 D------------------------GKTLTYALDPEL----ERLFLELA--LKCKAVICCRVSPLQKALVVKLVKKSKKA 671
                        410       420       430
                 ....*....|....*....|....*....|....*...
gi 767926595 845 VGMC-GDGANDCGALKAAHAGISLSEQE---ASVASPF 878
Cdd:cd02073  672 VTLAiGDGANDVSMIQEAHVGVGISGQEgmqAARASDY 709
P-type_ATPase_HM cd07553
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
210-945 2.44e-13

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319851 [Multi-domain]  Cd Length: 610  Bit Score: 74.09  E-value: 2.44e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 210 FQAFTLTLWLSQG--YIEYSVAIIILTVISIVLSVydlRQQSVKLHNLVEDHNKVQVTIIVKDKGLEELE-SRLLVPGDI 286
Cdd:cd07553   75 FVVSWYGLIKGDGlvYFDSLSVLVFLMLVGRWLQV---VTQERNRNRLADSRLEAPITEIETGSGSRIKTrADQIKSGDV 151
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 287 LILPGKFSLPCDAVLIDGSCVVNEGMLTGESIPVTKtplpqmentmpwkchsledYRKHVLFCGTEVIQvkpsgqGPVRA 366
Cdd:cd07553  152 YLVASGQRVPVDGKLLSEQASIDMSWLTGESLPRIV-------------------ERGDKVPAGTSLEN------QAFEI 206
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 367 VVLQTGYNTAKGDLVRSILYP--RPLNFKLYSD--AFKFIVFLACLGVMGFFYALGVYMYHGVppkdTVTMALILLTVTV 442
Cdd:cd07553  207 RVEHSLAESWSGSILQKVEAQeaRKTPRDLLADkiIHYFTVIALLIAVAGFGVWLAIDLSIAL----KVFTSVLIVACPC 282
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 443 PPVLPAALTIGNvyAQKRLKKKKIFCISPQRINMCGQINLVCFDKTGTLTEDgldlwgtvptadncfqeAHSFASGQavp 522
Cdd:cd07553  283 ALALATPFTDEI--ALARLKKKGVLIKNASSLERLSRVRTIVFDKTGTLTRG-----------------KSSFVMVN--- 340
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 523 wsplcaamaschslillngtiqGDPLDLKMFegtawkmedcivdsckfgtsvsNIIKpgpkaskspveAIITLCQFPFSS 602
Cdd:cd07553  341 ----------------------PEGIDRLAL----------------------RAIS-----------AIEAHSRHPISR 365
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 603 SLQR--MSVIAQLAGENHF-HVYMKGApemvarfcrsetvpknfpqelrSYTVQGFrVIALAHKTLKMGNLSEVEHLARE 679
Cdd:cd07553  366 AIREhlMAKGLIKAGASELvEIVGKGV----------------------SGNSSGS-LWKLGSAPDACGIQESGVVIARD 422
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 680 KveselTFLGLLIMENRLKKETKLVLKELSEARIRTVMITGDNLQTAITVAKnsemippgsqviiveadepeefvpasvt 759
Cdd:cd07553  423 G-----RQLLDLSFNDLLRPDSNREIEELKKGGLSIAILSGDNEEKVRLVGD---------------------------- 469
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 760 wqlvenqetgpgkkeiymhtgnsstprgeggscyhfamsgksyqvifqhfnsLLPkiLVNGTVFARMSPGQKSSLIEEFQ 839
Cdd:cd07553  470 ----------------------------------------------------SLG--LDPRQLFGNLSPEEKLAWIESHS 495
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 840 KLNyyVGMCGDGANDCGALKAAHAGISLSEQEA--SVASPFTSKTTNIQCVPHLI---REGRAALVSSFGVFKYLTMYGI 914
Cdd:cd07553  496 PEN--TLMVGDGANDALALASAFVGIAVAGEVGvsLEAADIYYAGNGIGGIRDLLtlsKQTIKAIKGLFAFSLLYNLVAI 573
                        730       740       750
                 ....*....|....*....|....*....|.
gi 767926595 915 IqfisalllywqLQLFGNYQYLmqdVAITLM 945
Cdd:cd07553  574 G-----------LALSGWISPL---VAAILM 590
P-type_ATPase_HM_ZosA_PfeT-like cd07551
P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which ...
263-865 4.93e-13

P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which transports copper, and perhaps zinc under oxidative stress, and perhaps ferrous iron; Bacillus subtilis ZosA/PfeT (previously known as YkvW) transports copper, it may also transport zinc under oxidative stress and may also be involved in ferrous iron efflux. ZosA/PfeT is expressed under the regulation of the peroxide-sensing repressor PerR. It is involved in competence development. Disruption of the zosA/pfeT gene results in low transformability. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319849 [Multi-domain]  Cd Length: 611  Bit Score: 73.05  E-value: 4.93e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 263 QVTIIVKDKGLEELESRLLVPGD-ILILPGKfSLPCDAVLIDGSCVVNEGMLTGESIPVTKTPlpqmentmpwkchsled 341
Cdd:cd07551  113 TARRIQRDGEIEEVPVEELQIGDrVQVRPGE-RVPADGVILSGSSSIDEASITGESIPVEKTP----------------- 174
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 342 yrKHVLFCGT-------EVIQVKPSGQGPVRAVVlqTGYNTAKGDLVRSILYprplnFKLYSDAFKFIVFLACLGVMGFF 414
Cdd:cd07551  175 --GDEVFAGTingsgalTVRVTKLSSDTVFAKIV--QLVEEAQSEKSPTQSF-----IERFERIYVKGVLLAVLLLLLLP 245
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 415 YALGvymyhGVPPKDTVTMALILLTVTVPPVL-----PAAL-TIGNVYAQKRLKKKKIFcispqrINMCGQINLVCFDKT 488
Cdd:cd07551  246 PFLL-----GWTWADSFYRAMVFLVVASPCALvastpPATLsAIANAARQGVLFKGGVH------LENLGSVKAIAFDKT 314
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 489 GTLTEDGLDLWGTVPTADNCFQEAHSFASGqavpwsplcAAMASCHslillngtiqgdPLdlkmfeGTAwkmedcIVdsc 568
Cdd:cd07551  315 GTLTEGKPRVTDVIPAEGVDEEELLQVAAA---------AESQSEH------------PL------AQA------IV--- 358
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 569 KFGTSvSNIIKPGPKAskspVEAIITlcqfpfssslqrMSVIAQLAGenhfHVYMKGAPEMVarfcrsETVPKNFPQElr 648
Cdd:cd07551  359 RYAEE-RGIPRLPAIE----VEAVTG------------KGVTATVDG----QTYRIGKPGFF------GEVGIPSEAA-- 409
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 649 sytvqgfrviALAHKTLKMGNlsEVEHLAREKVeseltFLGLLIMENRLKKETKLVLKELSEARIRTVMITGDNLQTAIT 728
Cdd:cd07551  410 ----------ALAAELESEGK--TVVYVARDDQ-----VVGLIALMDTPRPEAKEAIAALRLGGIKTIMLTGDNERTAEA 472
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 729 VAKNSEMippgsqviiveaDEpeefvpasvtwqlvenqetgpgkkeiymhtgnsstprgeggscyhfamsgksyqvifqh 808
Cdd:cd07551  473 VAKELGI------------DE----------------------------------------------------------- 481
                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767926595 809 fnsllpkilvngtVFARMSPGQKSSLIEEFQKLNYYVGMCGDGANDCGALKAAHAGI 865
Cdd:cd07551  482 -------------VVANLLPEDKVAIIRELQQEYGTVAMVGDGINDAPALANADVGI 525
P-type_ATPase_Cu-like cd07552
P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+) ...
268-865 1.39e-11

P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+)-ATPase; Archaeoglobus fulgidus CopB transports Cu(2+) from the cytoplasm to the exterior of the cell using ATP as energy source, it transports preferentially Cu(2+) over Cu(+), it is activated by Cu(2+) with high affinity and partially by Cu(+) and Ag(+). This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319850 [Multi-domain]  Cd Length: 632  Bit Score: 68.48  E-value: 1.39e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 268 VKDKGLEELESRLLVPGD-ILILPGKfSLPCDAVLIDGSCVVNEGMLTGESIPVTKTPlpqmentmpwkchsledyrkhv 346
Cdd:cd07552  136 VTDGSIEDVPVSELKVGDvVLVRAGE-KIPADGTILEGESSVNESMVTGESKPVEKKP---------------------- 192
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 347 lfcGTEVIQVKPSGQGPVRAVVLQTGYNTAKGDLVRSILYPR--PLNFKLYSDAFKFIVFLACLGVmGFFYALGVYMYHG 424
Cdd:cd07552  193 ---GDEVIGGSVNGNGTLEVKVTKTGEDSYLSQVMELVAQAQasKSRAENLADKVAGWLFYIALGV-GIIAFIIWLILGD 268
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 425 VPpkDTVTMALILLTVTVPPVL----PAALTIGNVYAQKR---LKKKKIFcispQRINmcgQINLVCFDKTGTLTEDGLD 497
Cdd:cd07552  269 LA--FALERAVTVLVIACPHALglaiPLVVARSTSIAAKNgllIRNREAL----ERAR---DIDVVLFDKTGTLTEGKFG 339
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 498 LWGTVPTADNCFQEAHSFASGqavpwsplcAAMASCHSLillngtIQGdpldlkmfegtawkmedcIVDSCKfgtsvsni 577
Cdd:cd07552  340 VTDVITFDEYDEDEILSLAAA---------LEAGSEHPL------AQA------------------IVSAAK-------- 378
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 578 ikpgpkaskspvEAIITLCQFPFSSSLQRMSVIAQLAGenhfHVYMKGAPEMVAR--FCRSETVPKNfpqelrsYTVQGF 655
Cdd:cd07552  379 ------------EKGIRPVEVENFENIPGVGVEGTVNG----KRYQVVSPKYLKElgLKYDEELVKR-------LAQQGN 435
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 656 RVIALAHktlkmgnlsevehlarekvESELtfLGLLIMENRLKKETKLVLKELSEARIRTVMITGDNLQTAITVAKnsem 735
Cdd:cd07552  436 TVSFLIQ-------------------DGEV--IGAIALGDEIKPESKEAIRALKAQGITPVMLTGDNEEVAQAVAE---- 490
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 736 ippgsQVIIVEadepeefvpasvtwqlvenqetgpgkkeiymhtgnsstprgeggscyhfamsgksyqvifqhfnsllpk 815
Cdd:cd07552  491 -----ELGIDE--------------------------------------------------------------------- 496
                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|
gi 767926595 816 ilvngtVFARMSPGQKSSLIEEFQKLNYYVGMCGDGANDCGALKAAHAGI 865
Cdd:cd07552  497 ------YFAEVLPEDKAKKVKELQAEGKKVAMVGDGVNDAPALAQADVGI 540
PLN03190 PLN03190
aminophospholipid translocase; Provisional
600-878 2.23e-08

aminophospholipid translocase; Provisional


Pssm-ID: 215623 [Multi-domain]  Cd Length: 1178  Bit Score: 58.37  E-value: 2.23e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595  600 FSSSLQRMSVIAQLAgENHFHVYMKGA-PEMVARFCRS--ETVPKNFPQELRSYTVQGFRVIALAHKTLkmgNLSEVE-- 674
Cdd:PLN03190  611 FDSDRKRMSVILGCP-DKTVKVFVKGAdTSMFSVIDRSlnMNVIRATEAHLHTYSSLGLRTLVVGMREL---NDSEFEqw 686
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595  675 HLARE------------------KVESELTFLGLLIMENRLKKETKLVLKELSEARIRTVMITGDNLQTAITVAKNSEMI 736
Cdd:PLN03190  687 HFSFEaastaligraallrkvasNVENNLTILGASAIEDKLQQGVPEAIESLRTAGIKVWVLTGDKQETAISIGYSSKLL 766
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595  737 PPGSQVIIVEADEPEEfVPASVTWQLVENQETGPgKKEIYMHTGNSS-TPRGE-----GGSCYHFAMSGKSYQVIFQhfn 810
Cdd:PLN03190  767 TNKMTQIIINSNSKES-CRKSLEDALVMSKKLTT-VSGISQNTGGSSaAASDPvaliiDGTSLVYVLDSELEEQLFQ--- 841
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767926595  811 sLLPKILVngTVFARMSPGQKSSLIEEFQKLNYYVGMC-GDGANDCGALKAAHAGISLSEQE---ASVASPF 878
Cdd:PLN03190  842 -LASKCSV--VLCCRVAPLQKAGIVALVKNRTSDMTLAiGDGANDVSMIQMADVGVGISGQEgrqAVMASDF 910
Cation_ATPase pfam13246
Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including ...
595-636 5.68e-08

Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including phospholipid-transporting ATPases, calcium-transporting ATPases, and sodium-potassium ATPases.


Pssm-ID: 463817 [Multi-domain]  Cd Length: 91  Bit Score: 51.07  E-value: 5.68e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 767926595  595 LCQFPFSSSLQRMSVIAQLAGENHFHVYMKGAPEMVARFCRS 636
Cdd:pfam13246  49 VAEIPFNSDRKRMSTVHKLPDDGKYRLFVKGAPEIILDRCTT 90
P-type_ATPase_K cd02078
potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic ...
202-731 8.98e-08

potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic high-affinity potassium uptake system KdpFABC; similar to Escherichia coli KdpB; KdpFABC is a prokaryotic high-affinity potassium uptake system. It is expressed under K(+) limiting conditions when the other potassium transport systems are not able to provide a sufficient flow of K(+) into the bacteria. The KdpB subunit represents the catalytic subunit performing ATP hydrolysis. KdpB is comprised of four domains: the transmembrane domain, the nucleotide-binding domain, the phosphorylation domain, and the actuator domain. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319773 [Multi-domain]  Cd Length: 667  Bit Score: 56.12  E-value: 8.98e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 202 QVLNP--FYVFQAFTLTLWL--------SQGYIEYSVAIII---LTVI--SIVLSVYDLR--QQSVKLHNLVEDhnkVQV 264
Cdd:cd02078   21 LAKNPvmFVVEIGSIITTVLtffpllfsGGGPAGFNLAVSLwlwFTVLfaNFAEAIAEGRgkAQADSLRKTKTE---TQA 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 265 TIIVKDKGLEELESRLLVPGDILILPGKFSLPCDAVLIDGSCVVNEGMLTGESIPVTKTPlpqmentmpwkchslEDYRK 344
Cdd:cd02078   98 KRLRNDGKIEKVPATDLKKGDIVLVEAGDIIPADGEVIEGVASVDESAITGESAPVIRES---------------GGDRS 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 345 HVLfCGTEVIqvkpSGQGPVRAVVlqtgyNTAKGDLVRSI-LYPR------P----LNFKLYSDAFKFIVFLACLgvmgf 413
Cdd:cd02078  163 SVT-GGTKVL----SDRIKVRITA-----NPGETFLDRMIaLVEGasrqktPneiaLTILLVGLTLIFLIVVATL----- 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 414 fYALGVYMYHGVPPkdtvtMALILLTVTVPPVLPAAL--TIGnVYAQKRLKKKKIFCISPQRINMCGQINLVCFDKTGTL 491
Cdd:cd02078  228 -PPFAEYSGAPVSV-----TVLVALLVCLIPTTIGGLlsAIG-IAGMDRLLRFNVIAKSGRAVEAAGDVDTLLLDKTGTI 300
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 492 TedgldlwgtvptadncfqeahsFASGQAVPWSPlcaamaschslilLNGTiqgdplDLKMFEGTAWKMEdcIVDSCKFG 571
Cdd:cd02078  301 T----------------------LGNRQATEFIP-------------VGGV------DEKELADAAQLAS--LADETPEG 337
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 572 TSVSNIIKP--GPKASKSPVEAiitlcQF-PFSSSlQRMSVIAQLAGENhfhvYMKGAPEMVARFCRSE--TVPKNFPQE 646
Cdd:cd02078  338 RSIVILAKQlgGTERDLDLSGA-----EFiPFSAE-TRMSGVDLPDGTE----IRKGAVDAIRKYVRSLggSIPEELEAI 407
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 647 LRSYTVQGFRVIALAHKTlkmgnlsevehlarekveselTFLGLLIMENRLKKETKLVLKELSEARIRTVMITGDNLQTA 726
Cdd:cd02078  408 VEEISKQGGTPLVVAEDD---------------------RVLGVIYLKDIIKPGIKERFAELRKMGIKTVMITGDNPLTA 466

                 ....*
gi 767926595 727 ITVAK 731
Cdd:cd02078  467 AAIAA 471
PRK14010 PRK14010
K(+)-transporting ATPase subunit B;
267-733 2.99e-07

K(+)-transporting ATPase subunit B;


Pssm-ID: 184448 [Multi-domain]  Cd Length: 673  Bit Score: 54.32  E-value: 2.99e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 267 IVKDKGLEELESRLLVPGDILILPGKFSLPCDAVLIDGSCVVNEGMLTGESIPVTKTPLPQMENTMPWKCHSlEDYrkhv 346
Cdd:PRK14010 109 IKQDGSYEMIDASDLKKGHIVRVATGEQIPNDGKVIKGLATVDESAITGESAPVIKESGGDFDNVIGGTSVA-SDW---- 183
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 347 lfcgTEVIQVKPSGQGPVRAVVLQTGYNTAKgdlvrsilyPRPLNFKLYSDAFKF-IVFLACLGVMgffYALGVYMYHGV 425
Cdd:PRK14010 184 ----LEVEITSEPGHSFLDKMIGLVEGATRK---------KTPNEIALFTLLMTLtIIFLVVILTM---YPLAKFLNFNL 247
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 426 ppkdTVTMALILLTVTVPPVLPAALTIGNVYAQKRLKKKKIFCISPQRINMCGQINLVCFDKTGTLTEDGLDLWGTVPTA 505
Cdd:PRK14010 248 ----SIAMLIALAVCLIPTTIGGLLSAIGIAGMDRVTQFNILAKSGRSVETCGDVNVLILDKTGTITYGNRMADAFIPVK 323
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 506 DNCFQEahsfasgqavpwspLCAAMASChslillngtiqgdpldlkmfegtawkmedCIVDSCKFGTSVSNIikpgpkAS 585
Cdd:PRK14010 324 SSSFER--------------LVKAAYES-----------------------------SIADDTPEGRSIVKL------AY 354
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 586 KSPVEAIITLCQ-FPFSSSlQRMSVIAQLAGEnhfhVYmKGAPEMVARfcRSETVPKNFPQELRSYTvqgfrvialaHKT 664
Cdd:PRK14010 355 KQHIDLPQEVGEyIPFTAE-TRMSGVKFTTRE----VY-KGAPNSMVK--RVKEAGGHIPVDLDALV----------KGV 416
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767926595 665 LKMGNLSEVehlarekVESELTFLGLLIMENRLKKETKLVLKELSEARIRTVMITGDNLQTAITVAKNS 733
Cdd:PRK14010 417 SKKGGTPLV-------VLEDNEILGVIYLKDVIKDGLVERFRELREMGIETVMCTGDNELTAATIAKEA 478
P-type_ATPase_HM cd07544
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
225-324 5.72e-07

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319844 [Multi-domain]  Cd Length: 596  Bit Score: 53.48  E-value: 5.72e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 225 EYSVAIIILTVISI--VLSVYDLRQQSVKLHNLVEdhNKVQVTIIVKDKGLEELESRLLVPGD-ILILPGKFsLPCDAVL 301
Cdd:cd07544   72 EYWASLIILLMLTGgeALEDYAQRRASRELTALLD--RAPRIAHRLVGGQLEEVPVEEVTVGDrLLVRPGEV-VPVDGEV 148
                         90       100
                 ....*....|....*....|...
gi 767926595 302 IDGSCVVNEGMLTGESIPVTKTP 324
Cdd:cd07544  149 VSGTATLDESSLTGESKPVSKRP 171
P-type_ATPase_Cd-like cd07545
P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a ...
267-867 2.34e-06

P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase; CadA from gram-positive Staphylococcus aureus plasmid pI258 is required for full Cd(2+) and Zn(2+) resistance. This subfamily also includes CadA, from the gram-negative bacilli, Stenotrophomonas maltophilia D457R, which is a cadmium efflux pump acquired as part of a cluster of antibiotic and heavy metal resistance genes from gram-positive bacteria. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319845 [Multi-domain]  Cd Length: 599  Bit Score: 51.27  E-value: 2.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 267 IVKDKGLEELESRLLVPGDILIL-PGKfSLPCDAVLIDGSCVVNEGMLTGESIPVTKTPlpqmentmpwkchsledyrKH 345
Cdd:cd07545  100 VRRDGQEREVPVAEVAVGDRMIVrPGE-RIAMDGIIVRGESSVNQAAITGESLPVEKGV-------------------GD 159
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 346 VLFCGT-------EVIQVKPSGQGPVRAVVlqtgyntakgDLVRSILYPR-PlnfklySDAF--KF------IVFLACLG 409
Cdd:cd07545  160 EVFAGTlngegalEVRVTKPAEDSTIARII----------HLVEEAQAERaP------TQAFvdRFaryytpVVMAIAAL 223
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 410 VmgffyALgvymyhgVPP-------KDTVTMALILLTVTVPPVLPAALTIGNVYAQKRLKKKKIFCISPQRINMCGQINL 482
Cdd:cd07545  224 V-----AI-------VPPlffggawFTWIYRGLALLVVACPCALVISTPVSIVSAIGNAARKGVLIKGGVYLEELGRLKT 291
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 483 VCFDKTGTLTEDGLDLWGTVPTADNCFQEAHSFASG-QAVPWSPLCAAmaschslILLNGTIQGDPLdlkmfegtawkme 561
Cdd:cd07545  292 VAFDKTGTLTKGKPVVTDVVVLGGQTEKELLAIAAAlEYRSEHPLASA-------IVKKAEQRGLTL------------- 351
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 562 dcivdsckfgtsvsniikpgpkaskSPVEaiitlcQFpfsSSLQRMSVIAQLAGEnhfhVYMKGAPEMVARFCRSETVPk 641
Cdd:cd07545  352 -------------------------SAVE------EF---TALTGRGVRGVVNGT----TYYIGSPRLFEELNLSESPA- 392
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 642 nFPQELRSYTVQGFRVIALAhktlkmgnlsevehlarekveSELTFLGLLIMENRLKKETKLVLKELSEARI-RTVMITG 720
Cdd:cd07545  393 -LEAKLDALQNQGKTVMILG---------------------DGERILGVIAVADQVRPSSRNAIAALHQLGIkQTVMLTG 450
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 721 DNLQTAITVAknsemippgSQVIIVEAdepeefvpasvtwqlvenqetgpgkkeiymhtgnsstpRGEggscyhfamsgk 800
Cdd:cd07545  451 DNPQTAQAIA---------AQVGVSDI--------------------------------------RAE------------ 471
                        570       580       590       600       610       620
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767926595 801 syqvifqhfnsLLPKilvngtvfarmspgQKSSLIEEFQKLNYYVGMCGDGANDCGALKAAHAGISL 867
Cdd:cd07545  472 -----------LLPQ--------------DKLDAIEALQAEGGRVAMVGDGVNDAPALAAADVGIAM 513
P-type_ATPase_HM cd07550
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
820-875 2.59e-06

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319848 [Multi-domain]  Cd Length: 592  Bit Score: 51.12  E-value: 2.59e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767926595 820 GTVFARMSPGQKSSLIEEFQKLNYYVGMCGDGANDCGALKAAHAGISLsEQEASVA 875
Cdd:cd07550  462 DRYHAEALPEDKAEIVEKLQAEGRTVAFVGDGINDSPALSYADVGISM-RGGTDIA 516
Cation_ATPase_N pfam00690
Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
170-239 4.45e-06

Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport.


Pssm-ID: 459907 [Multi-domain]  Cd Length: 68  Bit Score: 45.24  E-value: 4.45e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767926595  170 GLTSEEQEVRRLVCGPNAI-EVEIQPIWKLLVKQVLNPFyvfqaftltlwlsqgyieysvaIIILTVISIV 239
Cdd:pfam00690  20 GLTEAEAEKRLKKYGPNELpEKKPKSLWKLFLRQFKDPL----------------------IIILLIAAIV 68
P-type_ATPase_Pb_Zn_Cd2-like cd07546
P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective ...
266-493 1.32e-04

P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+); Escherichia coli ZntA mediates resistance to toxic levels of selected divalent metal ions. ZntA has the highest selectivity for Pb(2+), followed by Zn(2+) and Cd(2+); it also shows low levels of activity with Cu(2+), Ni(2+), and Co(2+). It is upregulated by the transcription factor ZntR at high zinc concentrations. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319846 [Multi-domain]  Cd Length: 597  Bit Score: 45.86  E-value: 1.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 266 IIVKDKGLEELESRLLVPGDIL-ILPGKfSLPCDAVLIDGSCVVNEGMLTGESIPVTKTPlpqmentmpwkchsledyrK 344
Cdd:cd07546  102 LREENGERREVPADSLRPGDVIeVAPGG-RLPADGELLSGFASFDESALTGESIPVEKAA-------------------G 161
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 345 HVLFCGT----EVIQVK----PSGQGPVRAVVLQTGYNTAKGDLVRSIlyprplnfklysDAFKFIVFLACLGVmgffyA 416
Cdd:cd07546  162 DKVFAGSinvdGVLRIRvtsaPGDNAIDRILHLIEEAEERRAPIERFI------------DRFSRWYTPAIMAV-----A 224
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595 417 LGVYMyhgVPPK------DT-VTMALILLTVTVPPVL----PAALTIGNVYAQKR--LKKkkifciSPQRINMCGQINLV 483
Cdd:cd07546  225 LLVIV---VPPLlfgadwQTwIYRGLALLLIGCPCALvistPAAITSGLAAAARRgaLIK------GGAALEQLGRVTTV 295
                        250
                 ....*....|
gi 767926595 484 CFDKTGTLTE 493
Cdd:cd07546  296 AFDKTGTLTR 305
Cation_ATPase_N smart00831
Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region ...
160-207 1.44e-04

Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region found in several classes of cation-transporting P-type ATPases, including those that transport H+, Na+, Ca2+, Na+/K+, and H+/K+. In the H+/K+- and Na+/K+-exchange P-ATPases, this domain is found in the catalytic alpha chain. In gastric H+/K+-ATPases, this domain undergoes reversible sequential phosphorylation inducing conformational changes that may be important for regulating the function of these ATPases.


Pssm-ID: 214842 [Multi-domain]  Cd Length: 75  Bit Score: 41.03  E-value: 1.44e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 767926595   160 CSDIHQTFGLGLTSEEQEVRRLVCGPNAIEV-EIQPIWKLLVKQVLNPF 207
Cdd:smart00831  13 LERLQTDLEKGLSSEEAARRLERYGPNELPPpKKTSPLLRFLRQFHNPL 61
P-type_ATPase-Cd_Zn_Co_like cd07548
P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to ...
268-324 1.50e-04

P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to transport cadmium, zinc and cobalt but not copper out of the cell; Bacillus subtilis CadA/YvgW appears to transport cadmium, zinc and cobalt but not copper, out of the cell. Functions in metal ion resistance and cellular metal ion homeostasis. CadA/YvgW is also important for sporulation in B. subtilis, the significant specific expression of the cadA/yvgW gene during the late stage of sporulation, is controlled by forespore-specific sigma factor, sigma G, and mother cell-specific sigma factor, sigma E. This subfamily also includes Helicobacter pylori CadA an essential resistance pump with ion specificity towards Cd(2+), Zn(2+) and Co(2+), and Zn-transporting ATPase, ZiaA(N) in Synechocystis PCC 6803. Transcription of ziaA is induced by Zn under the control of the Zn responsive repressor ZiaR. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319847 [Multi-domain]  Cd Length: 604  Bit Score: 45.69  E-value: 1.50e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767926595 268 VKDKGLEELESRLLVPGDILIL-PGKfSLPCDAVLIDGSCVVNEGMLTGESIPVTKTP 324
Cdd:cd07548  114 KRNNELKDVKPEEVQIGDIIVVkPGE-KIPLDGVVLKGESFLDTSALTGESVPVEVKE 170
zntA PRK11033
zinc/cadmium/mercury/lead-transporting ATPase; Provisional
265-324 3.94e-04

zinc/cadmium/mercury/lead-transporting ATPase; Provisional


Pssm-ID: 236827 [Multi-domain]  Cd Length: 741  Bit Score: 44.21  E-value: 3.94e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767926595 265 TIIVKDKGLEELESRLLVPGDIL-ILPGKfSLPCDAVLIDGSCVVNEGMLTGESIPVTKTP 324
Cdd:PRK11033 245 ATRLRDGEREEVAIADLRPGDVIeVAAGG-RLPADGKLLSPFASFDESALTGESIPVERAT 304
P-type_ATPase_FixI-like cd02092
Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ...
824-866 5.11e-04

Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ATPase subfamily; FixI may be a pump of a specific cation involved in symbiotic nitrogen fixation. The Rhizobium fixI gene is part of an operon conserved among rhizobia, fixGHIS. FixG, FixH, FixI, and FixS may participate in a membrane-bound complex coupling the FixI cation pump with a redox process catalyzed by FixG, an iron-sulfur protein. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319782 [Multi-domain]  Cd Length: 605  Bit Score: 43.89  E-value: 5.11e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 767926595 824 ARMSPGQKSSLIEEFQKLNYYVGMCGDGANDCGALKAAHAGIS 866
Cdd:cd02092  478 AGLTPAEKVARIEELKAQGRRVLMVGDGLNDAPALAAAHVSMA 520
Hydrolase pfam00702
haloacid dehalogenase-like hydrolase; This family is structurally different from the alpha ...
660-749 4.62e-03

haloacid dehalogenase-like hydrolase; This family is structurally different from the alpha/beta hydrolase family (pfam00561). This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases. The structure of the family consists of two domains. One is an inserted four helix bundle, which is the least well conserved region of the alignment, between residues 16 and 96 of Swiss:P24069. The rest of the fold is composed of the core alpha/beta domain. Those members with the characteriztic DxD triad at the N-terminus are probably phosphatidylglycerolphosphate (PGP) phosphatases involved in cardiolipin biosynthesis in the mitochondria.


Pssm-ID: 459910 [Multi-domain]  Cd Length: 191  Bit Score: 39.49  E-value: 4.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926595  660 LAHKTLKMGNLSEVEHLAREKVESELTFLGLLIMENRLKKETKLVLKELSEARIRTVMITGDNLQTAITVAKNSEMIPPG 739
Cdd:pfam00702  62 LEELDILRGLVETLEAEGLTVVLVELLGVIALADELKLYPGAAEALKALKERGIKVAILTGDNPEAAEALLRLLGLDDYF 141
                          90
                  ....*....|
gi 767926595  740 SQVIIVEADE 749
Cdd:pfam00702 142 DVVISGDDVG 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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