sperm flagellar protein 2 isoform X4 [Homo sapiens]
Protein Classification
bifunctional shikimate kinase/3-dehydroquinate synthase; bifunctional nucleoside/nucleotide kinase/histidine phosphatase family protein( domain architecture ID 10533623)
bifunctional shikimate kinase/3-dehydroquinate synthase functions in the shikimate pathway by catalyzing the specific phosphorylation of the 3-hydroxylgroup of shikimic acid using ATP as a cosubstrate and the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate to dehydroquinate| bifunctional nucleoside/nucleotide kinase (NK)/histidine phosphatase (HP) family protein contains an N-terminal NK domain that may catalyze the reversible phosphate group transfer from nucleoside triphosphates to nucleosides/nucleotides, nucleoside monophosphates, or sugars, and a C-terminal HP domain that contains a conserved His residue that is transiently phosphorylated during the catalytic cycle; similar to Schizosaccharomyces pombe 6-phosphofructo-2-kinase C222.13c
CH-like domain in sperm protein; Spef is a region of sperm flagellar proteins. It probably ...
5-97
3.60e-24
CH-like domain in sperm protein; Spef is a region of sperm flagellar proteins. It probably exerts a role in spermatogenesis in that the protein is expressed predominantly in adult tissue. It is present in the tails of developing and epididymal sperm internal to the fibrous sheath and around the dense outer fibres of the sperm flagellum. The amino-terminal domain (residues 1-110) shows a possible calponin homology (CH) domain; however Spef does not bind actin directly under in vitro conditions, so the function of the amino-terminal calponin-like domain is unclear. Transcription aberrations leading to a truncated protein result in immotile sperm.
:
Pssm-ID: 461871 Cd Length: 91 Bit Score: 98.27 E-value: 3.60e-24
Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of ...
686-868
8.64e-13
Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates to nucleosides/nucleotides, nucleoside monophosphates, or sugars. Members of this family play a wide variety of essential roles in nucleotide metabolism, the biosynthesis of coenzymes and aromatic compounds, as well as the metabolism of sugar and sulfate.
The actual alignment was detected with superfamily member cd01428:
Pssm-ID: 450170 [Multi-domain] Cd Length: 194 Bit Score: 69.19 E-value: 8.64e-13
CH-like domain in sperm protein; Spef is a region of sperm flagellar proteins. It probably ...
5-97
3.60e-24
CH-like domain in sperm protein; Spef is a region of sperm flagellar proteins. It probably exerts a role in spermatogenesis in that the protein is expressed predominantly in adult tissue. It is present in the tails of developing and epididymal sperm internal to the fibrous sheath and around the dense outer fibres of the sperm flagellum. The amino-terminal domain (residues 1-110) shows a possible calponin homology (CH) domain; however Spef does not bind actin directly under in vitro conditions, so the function of the amino-terminal calponin-like domain is unclear. Transcription aberrations leading to a truncated protein result in immotile sperm.
Pssm-ID: 461871 Cd Length: 91 Bit Score: 98.27 E-value: 3.60e-24
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
686-868
8.64e-13
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.
Pssm-ID: 238713 [Multi-domain] Cd Length: 194 Bit Score: 69.19 E-value: 8.64e-13
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
686-878
1.42e-09
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis
Pssm-ID: 440329 [Multi-domain] Cd Length: 212 Bit Score: 60.14 E-value: 1.42e-09
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
686-741
1.27e-07
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]
Pssm-ID: 273569 [Multi-domain] Cd Length: 210 Bit Score: 54.16 E-value: 1.27e-07
CH-like domain in sperm protein; Spef is a region of sperm flagellar proteins. It probably ...
5-97
3.60e-24
CH-like domain in sperm protein; Spef is a region of sperm flagellar proteins. It probably exerts a role in spermatogenesis in that the protein is expressed predominantly in adult tissue. It is present in the tails of developing and epididymal sperm internal to the fibrous sheath and around the dense outer fibres of the sperm flagellum. The amino-terminal domain (residues 1-110) shows a possible calponin homology (CH) domain; however Spef does not bind actin directly under in vitro conditions, so the function of the amino-terminal calponin-like domain is unclear. Transcription aberrations leading to a truncated protein result in immotile sperm.
Pssm-ID: 461871 Cd Length: 91 Bit Score: 98.27 E-value: 3.60e-24
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
686-868
8.64e-13
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.
Pssm-ID: 238713 [Multi-domain] Cd Length: 194 Bit Score: 69.19 E-value: 8.64e-13
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
686-878
1.42e-09
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis
Pssm-ID: 440329 [Multi-domain] Cd Length: 212 Bit Score: 60.14 E-value: 1.42e-09
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
686-741
1.27e-07
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]
Pssm-ID: 273569 [Multi-domain] Cd Length: 210 Bit Score: 54.16 E-value: 1.27e-07
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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