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Conserved domains on  [gi|767955335|ref|XP_011516352|]
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zinc finger CCHC domain-containing protein 7 isoform X2 [Homo sapiens]

Protein Classification

zinc finger CCHC domain-containing protein( domain architecture ID 1001245)

zinc finger CCHC domain-containing protein participates in many aspects of nucleic acid metabolism, from DNA transcription to RNA degradation, post-transcriptional gene silencing, and small RNA biogenesis.

CATH:  4.10.60.10
Gene Ontology:  GO:0008270|GO:0003676
PubMed:  32303790|33787465

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AIR1 super family cl34894
Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational ...
 238-326 3.84e-09

Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5082:

Pssm-ID: 227414 [Multi-domain]  Cd Length: 190  Bit Score: 56.40  E-value: 3.84e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767955335 238 NKNIICRNCDKRGHLSKNCPlprkVRRCFLCSRRGHLLYSCPAP-LCEYCPVPKMLDHSCLFRHSWDKQCDRCHMLGHYT 316
Cdd:COG5082   58 EENPVCFNCGQNGHLRRDCP----HSICYNCSWDGHRSNHCPKPkKCYNCGETGHLSRDCNPSKDQQKSCFDCNSTRHSS 133

                         90
                 ....*....|
gi 767955335 317 DACTEIWRQY 326
Cdd:COG5082  134 EDCPSIWKHY 143
 
Name Accession Description Interval E-value
AIR1 COG5082
Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational ...
 238-326 3.84e-09

Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion];


Pssm-ID: 227414 [Multi-domain]  Cd Length: 190  Bit Score: 56.40  E-value: 3.84e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767955335 238 NKNIICRNCDKRGHLSKNCPlprkVRRCFLCSRRGHLLYSCPAP-LCEYCPVPKMLDHSCLFRHSWDKQCDRCHMLGHYT 316
Cdd:COG5082   58 EENPVCFNCGQNGHLRRDCP----HSICYNCSWDGHRSNHCPKPkKCYNCGETGHLSRDCNPSKDQQKSCFDCNSTRHSS 133

                         90
                 ....*....|
gi 767955335 317 DACTEIWRQY 326
Cdd:COG5082  134 EDCPSIWKHY 143
PTZ00368 PTZ00368
universal minicircle sequence binding protein (UMSBP); Provisional
 236-319 3.68e-06

universal minicircle sequence binding protein (UMSBP); Provisional


Pssm-ID: 173561 [Multi-domain]  Cd Length: 148  Bit Score: 46.72  E-value: 3.68e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767955335 236 SANKNIICRNCDKRGHLSKNCP---LPRKVRRCFLCSRRGHLLYSCP-AP------LCEYCPVPKMLDHSCLFRHS---W 302
Cdd:PTZ00368  23 GAAKARPCYKCGEPGHLSRECPsapGGRGERSCYNCGKTGHLSRECPeAPpgsgprSCYNCGQTGHISRECPNRAKggaA 102

                         90
                 ....*....|....*..
gi 767955335 303 DKQCDRCHMLGHYTDAC 319
Cdd:PTZ00368 103 RRACYNCGGEGHISRDC 119
 
Name Accession Description Interval E-value
AIR1 COG5082
Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational ...
 238-326 3.84e-09

Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion];


Pssm-ID: 227414 [Multi-domain]  Cd Length: 190  Bit Score: 56.40  E-value: 3.84e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767955335 238 NKNIICRNCDKRGHLSKNCPlprkVRRCFLCSRRGHLLYSCPAP-LCEYCPVPKMLDHSCLFRHSWDKQCDRCHMLGHYT 316
Cdd:COG5082   58 EENPVCFNCGQNGHLRRDCP----HSICYNCSWDGHRSNHCPKPkKCYNCGETGHLSRDCNPSKDQQKSCFDCNSTRHSS 133

                         90
                 ....*....|
gi 767955335 317 DACTEIWRQY 326
Cdd:COG5082  134 EDCPSIWKHY 143
AIR1 COG5082
Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational ...
 259-325 5.58e-08

Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion];


Pssm-ID: 227414 [Multi-domain]  Cd Length: 190  Bit Score: 52.93  E-value: 5.58e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767955335 259 PRKVRRCFLCSRRGHLLYSCPAPLCEYCPVPkmlDHSCLfRHSWDKQCDRCHMLGHYTDACTEIWRQ 325
Cdd:COG5082   57 REENPVCFNCGQNGHLRRDCPHSICYNCSWD---GHRSN-HCPKPKKCYNCGETGHLSRDCNPSKDQ 119
PTZ00368 PTZ00368
universal minicircle sequence binding protein (UMSBP); Provisional
 236-319 3.68e-06

universal minicircle sequence binding protein (UMSBP); Provisional


Pssm-ID: 173561 [Multi-domain]  Cd Length: 148  Bit Score: 46.72  E-value: 3.68e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767955335 236 SANKNIICRNCDKRGHLSKNCP---LPRKVRRCFLCSRRGHLLYSCP-AP------LCEYCPVPKMLDHSCLFRHS---W 302
Cdd:PTZ00368  23 GAAKARPCYKCGEPGHLSRECPsapGGRGERSCYNCGKTGHLSRECPeAPpgsgprSCYNCGQTGHISRECPNRAKggaA 102

                         90
                 ....*....|....*..
gi 767955335 303 DKQCDRCHMLGHYTDAC 319
Cdd:PTZ00368 103 RRACYNCGGEGHISRDC 119
PTZ00368 PTZ00368
universal minicircle sequence binding protein (UMSBP); Provisional
 239-321 7.39e-06

universal minicircle sequence binding protein (UMSBP); Provisional


Pssm-ID: 173561 [Multi-domain]  Cd Length: 148  Bit Score: 45.95  E-value: 7.39e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767955335 239 KNIICRNCDKRGHLSKNCPLPRK----VRRCFLCSRRGHLLYSCPAPLCeycpvpkmldhsclfRHSWDKQCDRCHMLGH 314
Cdd:PTZ00368  76 GPRSCYNCGQTGHISRECPNRAKggaaRRACYNCGGEGHISRDCPNAGK---------------RPGGDKTCYNCGQTGH 140


                 ....*..
gi 767955335 315 YTDACTE 321
Cdd:PTZ00368 141 LSRDCPD 147
PTZ00368 PTZ00368
universal minicircle sequence binding protein (UMSBP); Provisional
 243-321 2.48e-04

universal minicircle sequence binding protein (UMSBP); Provisional


Pssm-ID: 173561 [Multi-domain]  Cd Length: 148  Bit Score: 41.33  E-value: 2.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767955335 243 CRNCDKRGHLSKNCP-----LPRKVRRCFLCSRRGHLLYSCPAPL-------CEYCPVPKMLDHSCLFR--HSWDKQCDR 308
Cdd:PTZ00368   3 CYRCGGVGHQSRECPnsapaGAAKARPCYKCGEPGHLSRECPSAPggrgersCYNCGKTGHLSRECPEAppGSGPRSCYN 82

                         90
                 ....*....|...
gi 767955335 309 CHMLGHYTDACTE 321
Cdd:PTZ00368  83 CGQTGHISRECPN 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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