NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|767985352|ref|XP_011520345|]
View 

thrombospondin type-1 domain-containing protein 4 isoform X3 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 91-206 5.51e-34

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


:

Pssm-ID: 461796  Cd Length: 115  Bit Score: 125.77  E-value: 5.51e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985352   91 VVSGVFKHALtSLGYHRVVEIPEGATKINITEMYKSNNYLALRSRSGRSIINGNWAID-RPGKYEGGGTMFTYKRpneiS 169
Cdd:pfam05986   1 TVSGSFTEGR-AKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKNVQGKYILNGKGSISlNPTYPSLLGTVLEYRR----S 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 767985352  170 STAGESFLAEGPTNEILDVYMIHQ---QPNPGVHYEYVIM 206
Cdd:pfam05986  76 LPALEELHAPGPTQEDLEIQVLRQygkGTNPGITYEYFIP 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 534-590 1.15e-13

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 65.94  E-value: 1.15e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767985352  534 WFAGSWSQCSIECGSGTQQREVICVRKnaDTFEVLDPSECSFLEKPPSQQSCHLKPC 590
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQK--GGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 358-414 8.51e-13

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 63.24  E-value: 8.51e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767985352  358 WDIGEWSECSKTCGLGMQHRQVLCRQVYANRslTVQPYRCQHLEKPETTSTCQLKIC 414
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGS--IVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 417-471 1.34e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 57.08  E-value: 1.34e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767985352  417 WQIrTDWTSCSVPCGVGQRTRDVKCV-SNIGDVVDDEECNMKLRPNDIENCDMGPC 471
Cdd:pfam19030   1 WVA-GPWGECSVTCGGGVQTRLVQCVqKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
PLAC pfam08686
PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short ...
 653-683 1.67e-10

PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short six-cysteine region that is usually found at the C terminal of proteins. It is found in a range of proteins including PACE4 (paired basic amino acid cleaving enzyme 4) and the extracellular matrix protein lacunin.


:

Pssm-ID: 462560  Cd Length: 31  Bit Score: 56.00  E-value: 1.67e-10
                          10        20        30
                  ....*....|....*....|....*....|.
gi 767985352  653 CKDKYYNCNVVVQARLCVYNYYKTACCASCT 683
Cdd:pfam08686   1 CKDKFANCSLVVQARLCSHKYYRQFCCRSCS 31
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 594-645 1.02e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 54.77  E-value: 1.02e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767985352  594 WFSTEWSMCSKSCQGGFRVREVRC---LSDDMTLSNLCDPQLKPEERESCNPQDC 645
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCvqkGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 305-354 2.63e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 50.53  E-value: 2.63e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 767985352  305 TECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPtPEEEPCNIFPC 354
Cdd:pfam19030   7 GECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKP-PETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 475-528 6.44e-06

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 43.98  E-value: 6.44e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767985352  475 WFLTEWSErCSAECGAGVRTRSVVCMTNHVSSL-PLEGCGNN-RPAEATPCDNGPC 528
Cdd:pfam19030   1 WVAGPWGE-CSVTCGGGVQTRLVQCVQKGGGSIvPDSECSAQkKPPETQSCNLKPC 55
 
Name Accession Description Interval E-value
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 91-206 5.51e-34

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 125.77  E-value: 5.51e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985352   91 VVSGVFKHALtSLGYHRVVEIPEGATKINITEMYKSNNYLALRSRSGRSIINGNWAID-RPGKYEGGGTMFTYKRpneiS 169
Cdd:pfam05986   1 TVSGSFTEGR-AKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKNVQGKYILNGKGSISlNPTYPSLLGTVLEYRR----S 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 767985352  170 STAGESFLAEGPTNEILDVYMIHQ---QPNPGVHYEYVIM 206
Cdd:pfam05986  76 LPALEELHAPGPTQEDLEIQVLRQygkGTNPGITYEYFIP 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 534-590 1.15e-13

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 65.94  E-value: 1.15e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767985352  534 WFAGSWSQCSIECGSGTQQREVICVRKnaDTFEVLDPSECSFLEKPPSQQSCHLKPC 590
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQK--GGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 358-414 8.51e-13

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 63.24  E-value: 8.51e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767985352  358 WDIGEWSECSKTCGLGMQHRQVLCRQVYANRslTVQPYRCQHLEKPETTSTCQLKIC 414
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGS--IVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 417-471 1.34e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 57.08  E-value: 1.34e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767985352  417 WQIrTDWTSCSVPCGVGQRTRDVKCV-SNIGDVVDDEECNMKLRPNDIENCDMGPC 471
Cdd:pfam19030   1 WVA-GPWGECSVTCGGGVQTRLVQCVqKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
PLAC pfam08686
PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short ...
 653-683 1.67e-10

PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short six-cysteine region that is usually found at the C terminal of proteins. It is found in a range of proteins including PACE4 (paired basic amino acid cleaving enzyme 4) and the extracellular matrix protein lacunin.


Pssm-ID: 462560  Cd Length: 31  Bit Score: 56.00  E-value: 1.67e-10
                          10        20        30
                  ....*....|....*....|....*....|.
gi 767985352  653 CKDKYYNCNVVVQARLCVYNYYKTACCASCT 683
Cdd:pfam08686   1 CKDKFANCSLVVQARLCSHKYYRQFCCRSCS 31
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 594-645 1.02e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 54.77  E-value: 1.02e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767985352  594 WFSTEWSMCSKSCQGGFRVREVRC---LSDDMTLSNLCDPQLKPEERESCNPQDC 645
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCvqkGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 305-354 2.63e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 50.53  E-value: 2.63e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 767985352  305 TECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPtPEEEPCNIFPC 354
Cdd:pfam19030   7 GECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKP-PETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 475-528 6.44e-06

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 43.98  E-value: 6.44e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767985352  475 WFLTEWSErCSAECGAGVRTRSVVCMTNHVSSL-PLEGCGNN-RPAEATPCDNGPC 528
Cdd:pfam19030   1 WVAGPWGE-CSVTCGGGVQTRLVQCVQKGGGSIvPDSECSAQkKPPETQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 414-471 1.18e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 40.26  E-value: 1.18e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 767985352   414 CSEWqirTDWTSCSVPCGVGQRTRDVKCVSNIGDvVDDEECNMKLRpnDIENCDMGPC 471
Cdd:smart00209   1 WSEW---SEWSPCSVTCGGGVQTRTRSCCSPPPQ-NGGGPCTGEDV--ETRACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 597-645 3.79e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 38.72  E-value: 3.79e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 767985352   597 TEWSMCSKSCQGGFRVREVRCLSDDMTLS-NLCDPQLKpeERESCNPQDC 645
Cdd:smart00209   5 SEWSPCSVTCGGGVQTRTRSCCSPPPQNGgGPCTGEDV--ETRACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 358-381 4.85e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 38.34  E-value: 4.85e-04
                           10        20
                   ....*....|....*....|....
gi 767985352   358 WDIGEWSECSKTCGLGMQHRQVLC 381
Cdd:smart00209   2 SEWSEWSPCSVTCGGGVQTRTRSC 25
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 537-590 4.59e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 35.64  E-value: 4.59e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 767985352   537 GSWSQCSIECGSGTQQREVICVRKNADtfevLDPSECSflEKPPSQQSCHLKPC 590
Cdd:smart00209   5 SEWSPCSVTCGGGVQTRTRSCCSPPPQ----NGGGPCT--GEDVETRACNEQPC 52
 
Name Accession Description Interval E-value
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 91-206 5.51e-34

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 125.77  E-value: 5.51e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985352   91 VVSGVFKHALtSLGYHRVVEIPEGATKINITEMYKSNNYLALRSRSGRSIINGNWAID-RPGKYEGGGTMFTYKRpneiS 169
Cdd:pfam05986   1 TVSGSFTEGR-AKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKNVQGKYILNGKGSISlNPTYPSLLGTVLEYRR----S 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 767985352  170 STAGESFLAEGPTNEILDVYMIHQ---QPNPGVHYEYVIM 206
Cdd:pfam05986  76 LPALEELHAPGPTQEDLEIQVLRQygkGTNPGITYEYFIP 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 534-590 1.15e-13

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 65.94  E-value: 1.15e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767985352  534 WFAGSWSQCSIECGSGTQQREVICVRKnaDTFEVLDPSECSFLEKPPSQQSCHLKPC 590
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQK--GGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 358-414 8.51e-13

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 63.24  E-value: 8.51e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767985352  358 WDIGEWSECSKTCGLGMQHRQVLCRQVYANRslTVQPYRCQHLEKPETTSTCQLKIC 414
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGS--IVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 417-471 1.34e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 57.08  E-value: 1.34e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767985352  417 WQIrTDWTSCSVPCGVGQRTRDVKCV-SNIGDVVDDEECNMKLRPNDIENCDMGPC 471
Cdd:pfam19030   1 WVA-GPWGECSVTCGGGVQTRLVQCVqKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
PLAC pfam08686
PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short ...
 653-683 1.67e-10

PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short six-cysteine region that is usually found at the C terminal of proteins. It is found in a range of proteins including PACE4 (paired basic amino acid cleaving enzyme 4) and the extracellular matrix protein lacunin.


Pssm-ID: 462560  Cd Length: 31  Bit Score: 56.00  E-value: 1.67e-10
                          10        20        30
                  ....*....|....*....|....*....|.
gi 767985352  653 CKDKYYNCNVVVQARLCVYNYYKTACCASCT 683
Cdd:pfam08686   1 CKDKFANCSLVVQARLCSHKYYRQFCCRSCS 31
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 594-645 1.02e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 54.77  E-value: 1.02e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767985352  594 WFSTEWSMCSKSCQGGFRVREVRC---LSDDMTLSNLCDPQLKPEERESCNPQDC 645
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCvqkGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 305-354 2.63e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 50.53  E-value: 2.63e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 767985352  305 TECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPtPEEEPCNIFPC 354
Cdd:pfam19030   7 GECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKP-PETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 475-528 6.44e-06

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 43.98  E-value: 6.44e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767985352  475 WFLTEWSErCSAECGAGVRTRSVVCMTNHVSSL-PLEGCGNN-RPAEATPCDNGPC 528
Cdd:pfam19030   1 WVAGPWGE-CSVTCGGGVQTRLVQCVQKGGGSIvPDSECSAQkKPPETQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 414-471 1.18e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 40.26  E-value: 1.18e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 767985352   414 CSEWqirTDWTSCSVPCGVGQRTRDVKCVSNIGDvVDDEECNMKLRpnDIENCDMGPC 471
Cdd:smart00209   1 WSEW---SEWSPCSVTCGGGVQTRTRSCCSPPPQ-NGGGPCTGEDV--ETRACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 597-645 3.79e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 38.72  E-value: 3.79e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 767985352   597 TEWSMCSKSCQGGFRVREVRCLSDDMTLS-NLCDPQLKpeERESCNPQDC 645
Cdd:smart00209   5 SEWSPCSVTCGGGVQTRTRSCCSPPPQNGgGPCTGEDV--ETRACNEQPC 52
TSP_1 pfam00090
Thrombospondin type 1 domain;
415-471 4.84e-04

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 38.55  E-value: 4.84e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767985352  415 SEWqirTDWTSCSVPCGVGQRTRDVKCVSNigdVVDDEECNMKLRPNDIenCDMGPC 471
Cdd:pfam00090   1 SPW---SPWSPCSVTCGKGIQVRQRTCKSP---FPGGEPCTGDDIETQA--CKMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 358-381 4.85e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 38.34  E-value: 4.85e-04
                           10        20
                   ....*....|....*....|....
gi 767985352   358 WDIGEWSECSKTCGLGMQHRQVLC 381
Cdd:smart00209   2 SEWSEWSPCSVTCGGGVQTRTRSC 25
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 361-394 1.17e-03

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 37.26  E-value: 1.17e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 767985352  361 GEWSECSKTCGLGMQHRQvlcrqvyanRSLTVQP 394
Cdd:pfam19028   7 SEWSECSVTCGGGVQTRT---------RTVIVEP 31
TSP_1 pfam00090
Thrombospondin type 1 domain;
361-381 1.76e-03

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 36.63  E-value: 1.76e-03
                          10        20
                  ....*....|....*....|.
gi 767985352  361 GEWSECSKTCGLGMQHRQVLC 381
Cdd:pfam00090   4 SPWSPCSVTCGKGIQVRQRTC 24
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 537-590 4.59e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 35.64  E-value: 4.59e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 767985352   537 GSWSQCSIECGSGTQQREVICVRKNADtfevLDPSECSflEKPPSQQSCHLKPC 590
Cdd:smart00209   5 SEWSPCSVTCGGGVQTRTRSCCSPPPQ----NGGGPCT--GEDVETRACNEQPC 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH