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Conserved domains on  [gi|767989838|ref|XP_011521352|]
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bromodomain-containing protein 7 isoform X10 [Homo sapiens]

Protein Classification

bromodomain-containing protein( domain architecture ID 10246121)

bromodomain-containing protein may act as transcription regulator involved in chromatin-based DNA damage response (DDR) pathways, which maintain genome integrity from cell-intrinsic and extrinsic DNA-damaging sources; also contains a DUF3512 domain

CATH:  1.20.920.10
Gene Ontology:  GO:0005515|GO:0006338|GO:0006357|GO:0070577
PubMed:  26472704|1350857|34548613|28847823|31582847
SCOP:  4000871

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF3512 pfam12024
Domain of unknown function (DUF3512); This presumed domain is functionally uncharacterized. ...
 96-279 4.55e-94

Domain of unknown function (DUF3512); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is typically between 231 to 249 amino acids in length. This domain is found associated with pfam00439.


:

Pssm-ID: 463436  Cd Length: 186  Bit Score: 281.44  E-value: 4.55e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989838   96 DKDMLEDKFKSnnlEREQEQLDRIVKESGGKLTRRLVNSQCEFERRKPDGTTTLGLLHPVDPIVGEPG-YCPVRLGMTTG 174
Cdd:pfam12024   1 KFEALPDDMTP---EEILEQVQKAAKEARDRLSRRKPNSKMGFLRRKKDGTTTLNILNPADPDAGEPGaERPVTLGMLVG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989838  175 RLQSGVNTLQGFKEDKRNKVTPVLYLNYGPYSSYAPHYDSTFANISKDDSDLIYSTYGEDSDLPSDFSIHEFLATCQDYP 254
Cdd:pfam12024  78 KLQSGTNTLQGFKEDKRNKVTPVSYLNYGPFSSYAPTYDSTFANLTKEESDLLYSTYGDETGVQYAESIQEFVKDCGDYM 157

                         170       180
                  ....*....|....*....|....*
gi 767989838  255 YVMADSLLDVLTKGGHSRTLQEMEM 279
Cdd:pfam12024 158 LKMVDDLLDLLTNGEHSKTLKELEE 182
Bromodomain super family cl02556
Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear ...
 1-30 1.32e-15

Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


The actual alignment was detected with superfamily member cd05513:

Pssm-ID: 445827  Cd Length: 98  Bit Score: 72.06  E-value: 1.32e-15
                         10        20        30
                 ....*....|....*....|....*....|
gi 767989838   1 MCTNAMIYNKPETIYYKAAKKLLHSGMKIL 30
Cdd:cd05513   69 MCENAMKYNKPDTIYYKAAKKLLHSGMKIL 98
 
Name Accession Description Interval E-value
DUF3512 pfam12024
Domain of unknown function (DUF3512); This presumed domain is functionally uncharacterized. ...
 96-279 4.55e-94

Domain of unknown function (DUF3512); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is typically between 231 to 249 amino acids in length. This domain is found associated with pfam00439.


Pssm-ID: 463436  Cd Length: 186  Bit Score: 281.44  E-value: 4.55e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989838   96 DKDMLEDKFKSnnlEREQEQLDRIVKESGGKLTRRLVNSQCEFERRKPDGTTTLGLLHPVDPIVGEPG-YCPVRLGMTTG 174
Cdd:pfam12024   1 KFEALPDDMTP---EEILEQVQKAAKEARDRLSRRKPNSKMGFLRRKKDGTTTLNILNPADPDAGEPGaERPVTLGMLVG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989838  175 RLQSGVNTLQGFKEDKRNKVTPVLYLNYGPYSSYAPHYDSTFANISKDDSDLIYSTYGEDSDLPSDFSIHEFLATCQDYP 254
Cdd:pfam12024  78 KLQSGTNTLQGFKEDKRNKVTPVSYLNYGPFSSYAPTYDSTFANLTKEESDLLYSTYGDETGVQYAESIQEFVKDCGDYM 157

                         170       180
                  ....*....|....*....|....*
gi 767989838  255 YVMADSLLDVLTKGGHSRTLQEMEM 279
Cdd:pfam12024 158 LKMVDDLLDLLTNGEHSKTLKELEE 182
Bromo_brd7_like cd05513
Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown ...
 1-30 1.32e-15

Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene involved in nasopharyngeal carcinoma. The protein interacts with acetylated histone H3 via its bromodomain. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99945  Cd Length: 98  Bit Score: 72.06  E-value: 1.32e-15
                         10        20        30
                 ....*....|....*....|....*....|
gi 767989838   1 MCTNAMIYNKPETIYYKAAKKLLHSGMKIL 30
Cdd:cd05513   69 MCENAMKYNKPDTIYYKAAKKLLHSGMKIL 98
BROMO smart00297
bromo domain;
1-33 2.36e-04

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 40.34  E-value: 2.36e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 767989838     1 MCTNAMIYNKPETIYYKAAKKLLHSGMKILSQE 33
Cdd:smart00297  75 MFSNARTYNGPDSEVYKDAKKLEKFFEKKLREL 107
 
Name Accession Description Interval E-value
DUF3512 pfam12024
Domain of unknown function (DUF3512); This presumed domain is functionally uncharacterized. ...
 96-279 4.55e-94

Domain of unknown function (DUF3512); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is typically between 231 to 249 amino acids in length. This domain is found associated with pfam00439.


Pssm-ID: 463436  Cd Length: 186  Bit Score: 281.44  E-value: 4.55e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989838   96 DKDMLEDKFKSnnlEREQEQLDRIVKESGGKLTRRLVNSQCEFERRKPDGTTTLGLLHPVDPIVGEPG-YCPVRLGMTTG 174
Cdd:pfam12024   1 KFEALPDDMTP---EEILEQVQKAAKEARDRLSRRKPNSKMGFLRRKKDGTTTLNILNPADPDAGEPGaERPVTLGMLVG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989838  175 RLQSGVNTLQGFKEDKRNKVTPVLYLNYGPYSSYAPHYDSTFANISKDDSDLIYSTYGEDSDLPSDFSIHEFLATCQDYP 254
Cdd:pfam12024  78 KLQSGTNTLQGFKEDKRNKVTPVSYLNYGPFSSYAPTYDSTFANLTKEESDLLYSTYGDETGVQYAESIQEFVKDCGDYM 157

                         170       180
                  ....*....|....*....|....*
gi 767989838  255 YVMADSLLDVLTKGGHSRTLQEMEM 279
Cdd:pfam12024 158 LKMVDDLLDLLTNGEHSKTLKELEE 182
Bromo_brd7_like cd05513
Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown ...
 1-30 1.32e-15

Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene involved in nasopharyngeal carcinoma. The protein interacts with acetylated histone H3 via its bromodomain. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99945  Cd Length: 98  Bit Score: 72.06  E-value: 1.32e-15
                         10        20        30
                 ....*....|....*....|....*....|
gi 767989838   1 MCTNAMIYNKPETIYYKAAKKLLHSGMKIL 30
Cdd:cd05513   69 MCENAMKYNKPDTIYYKAAKKLLHSGMKIL 98
BROMO smart00297
bromo domain;
1-33 2.36e-04

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 40.34  E-value: 2.36e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 767989838     1 MCTNAMIYNKPETIYYKAAKKLLHSGMKILSQE 33
Cdd:smart00297  75 MFSNARTYNGPDSEVYKDAKKLEKFFEKKLREL 107
Bromo_gcn5_like cd05509
Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates ...
 1-22 2.51e-03

Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99941 [Multi-domain]  Cd Length: 101  Bit Score: 37.15  E-value: 2.51e-03
                         10        20
                 ....*....|....*....|..
gi 767989838   1 MCTNAMIYNKPETIYYKAAKKL 22
Cdd:cd05509   69 IFDNCRLYNGPDTEYYKCANKL 90
Bromodomain cd04369
Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear ...
 1-23 3.06e-03

Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99922 [Multi-domain]  Cd Length: 99  Bit Score: 36.97  E-value: 3.06e-03
                         10        20
                 ....*....|....*....|...
gi 767989838   1 MCTNAMIYNKPETIYYKAAKKLL 23
Cdd:cd04369   70 IFSNAKTYNGPGSPIYKDAKKLE 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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