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Conserved domains on  [gi|767991840|ref|XP_011522041|]
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rap1 GTPase-activating protein 2 isoform X1 [Homo sapiens]

Protein Classification

GTPase-activating protein( domain architecture ID 10489639)

GTPase-activating protein functions as a GTPase activator for small GTPases, similar to Homo sapiens Rap1 GTPase-activating protein 2, a GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state

CATH:  3.40.50.11210|2.20.140.30
Gene Ontology:  GO:0051056|GO:0005096

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Rap_GAP pfam02145
Rap/ran-GAP;
304-483 6.14e-90

Rap/ran-GAP;


:

Pssm-ID: 460463  Cd Length: 179  Bit Score: 279.78  E-value: 6.14e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991840  304 FGNNEESPAFKEFLDLLGDTITLQDFKGFRGGLDVTHGQTGVESVYTTFRDREIMFHVSTKLPFTDGDAQQLQRKRHIGN 383
Cdd:pfam02145   1 LSNEEGSPAYEEFLNLLGWLVELKGFKGYRGGLDTKNNTTGEYSYYWADRGTEIMFHVSTLMPTTENDPQQLEKKRHIGN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991840  384 DIVAIIFQEENTPFVPDMIASNFLHAYIVVQVETPGTETPSYKVSVTAREDVPTFGPPLPSPPVFQKG--PEFREFLltk 461
Cdd:pfam02145  81 DIVNIVFNESGGPFDPSTIKSQFNHVFIVVQPNLPDTDNTLYRVSVVRKDDVPPFGPLLPDPKIFSKDnlPEFVRFL--- 157

                         170       180
                  ....*....|....*....|..
gi 767991840  462 LTNAENACCKSDKFAKLEDRTR 483
Cdd:pfam02145 158 AINAERAALKSSSFAERLRRIR 179
 
Name Accession Description Interval E-value
Rap_GAP pfam02145
Rap/ran-GAP;
304-483 6.14e-90

Rap/ran-GAP;


Pssm-ID: 460463  Cd Length: 179  Bit Score: 279.78  E-value: 6.14e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991840  304 FGNNEESPAFKEFLDLLGDTITLQDFKGFRGGLDVTHGQTGVESVYTTFRDREIMFHVSTKLPFTDGDAQQLQRKRHIGN 383
Cdd:pfam02145   1 LSNEEGSPAYEEFLNLLGWLVELKGFKGYRGGLDTKNNTTGEYSYYWADRGTEIMFHVSTLMPTTENDPQQLEKKRHIGN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991840  384 DIVAIIFQEENTPFVPDMIASNFLHAYIVVQVETPGTETPSYKVSVTAREDVPTFGPPLPSPPVFQKG--PEFREFLltk 461
Cdd:pfam02145  81 DIVNIVFNESGGPFDPSTIKSQFNHVFIVVQPNLPDTDNTLYRVSVVRKDDVPPFGPLLPDPKIFSKDnlPEFVRFL--- 157

                         170       180
                  ....*....|....*....|..
gi 767991840  462 LTNAENACCKSDKFAKLEDRTR 483
Cdd:pfam02145 158 AINAERAALKSSSFAERLRRIR 179
 
Name Accession Description Interval E-value
Rap_GAP pfam02145
Rap/ran-GAP;
304-483 6.14e-90

Rap/ran-GAP;


Pssm-ID: 460463  Cd Length: 179  Bit Score: 279.78  E-value: 6.14e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991840  304 FGNNEESPAFKEFLDLLGDTITLQDFKGFRGGLDVTHGQTGVESVYTTFRDREIMFHVSTKLPFTDGDAQQLQRKRHIGN 383
Cdd:pfam02145   1 LSNEEGSPAYEEFLNLLGWLVELKGFKGYRGGLDTKNNTTGEYSYYWADRGTEIMFHVSTLMPTTENDPQQLEKKRHIGN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991840  384 DIVAIIFQEENTPFVPDMIASNFLHAYIVVQVETPGTETPSYKVSVTAREDVPTFGPPLPSPPVFQKG--PEFREFLltk 461
Cdd:pfam02145  81 DIVNIVFNESGGPFDPSTIKSQFNHVFIVVQPNLPDTDNTLYRVSVVRKDDVPPFGPLLPDPKIFSKDnlPEFVRFL--- 157

                         170       180
                  ....*....|....*....|..
gi 767991840  462 LTNAENACCKSDKFAKLEDRTR 483
Cdd:pfam02145 158 AINAERAALKSSSFAERLRRIR 179
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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