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Conserved domains on  [gi|768004085|ref|XP_011526603|]
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transducin-like enhancer protein 6 isoform X2 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 159-438 2.47e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 70.06  E-value: 2.47e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004085 159 ILAHGELVLATAISSFTRHVFTCGRRG-IKVWSLTGQVAEDRFpESHLpiqtpgAFLRTCLLSSNSRSLLTGGYNlASVS 237
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSGDGtIKVWDLETGELLRTL-KGHT------GPVRDVAASADGTYLASGSSD-KTIR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004085 238 VWDLAAPSLHVKEQLPCAGLNCqaLDANLDANLAFASFTSGVVRIWDLRDQSVVRDLKGYPDGVKSIVVKGYN--IWTGG 315
Cdd:cd00200   77 LWDLETGECVRTLTGHTSYVSS--VAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGtfVASSS 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004085 316 PDACLRCWDQRTiMKPLE--YQFKSQIMSLSHSPQEDWVLLGMANGQ--QWLQSTSGSQRHMVGQKDSViLSVKFSPFGQ 391
Cdd:cd00200  155 QDGTIKLWDLRT-GKCVAtlTGHTGEVNSVAFSPDGEKLLSSSSDGTikLWDLSTGKCLGTLRGHENGV-NSVAFSPDGY 232

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 768004085 392 WWASVGMDDFLGVYSMPAGTKVFEVPE-MSPVTCCDVSSNNRLVVTGS 438
Cdd:cd00200  233 LLASGSEDGTIRVWDLRTGECVQTLSGhTNSVTSLAWSPDGKRLASGS 280
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 159-438 2.47e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 70.06  E-value: 2.47e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004085 159 ILAHGELVLATAISSFTRHVFTCGRRG-IKVWSLTGQVAEDRFpESHLpiqtpgAFLRTCLLSSNSRSLLTGGYNlASVS 237
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSGDGtIKVWDLETGELLRTL-KGHT------GPVRDVAASADGTYLASGSSD-KTIR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004085 238 VWDLAAPSLHVKEQLPCAGLNCqaLDANLDANLAFASFTSGVVRIWDLRDQSVVRDLKGYPDGVKSIVVKGYN--IWTGG 315
Cdd:cd00200   77 LWDLETGECVRTLTGHTSYVSS--VAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGtfVASSS 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004085 316 PDACLRCWDQRTiMKPLE--YQFKSQIMSLSHSPQEDWVLLGMANGQ--QWLQSTSGSQRHMVGQKDSViLSVKFSPFGQ 391
Cdd:cd00200  155 QDGTIKLWDLRT-GKCVAtlTGHTGEVNSVAFSPDGEKLLSSSSDGTikLWDLSTGKCLGTLRGHENGV-NSVAFSPDGY 232

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 768004085 392 WWASVGMDDFLGVYSMPAGTKVFEVPE-MSPVTCCDVSSNNRLVVTGS 438
Cdd:cd00200  233 LLASGSEDGTIRVWDLRTGECVQTLSGhTNSVTSLAWSPDGKRLASGS 280
WD40 COG2319
WD40 repeat [General function prediction only];
270-439 3.99e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.55  E-value: 3.99e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004085 270 LAFASFtSGVVRIWDLRDQSVVRDLKGYPDGVKSIVV--KGYNIWTGGPDACLRCWDQRT--IMKPLEYQfKSQIMSLSH 345
Cdd:COG2319  219 LASGSA-DGTVRLWDLATGKLLRTLTGHSGSVRSVAFspDGRLLASGSADGTVRLWDLATgeLLRTLTGH-SGGVNSVAF 296

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004085 346 SPQEDWVLLGMANGQ-QWLQSTSGSQRHMVGQKDSVILSVKFSPFGQWWASVGMDDFLGVYSMPAGTKVFEVPEMS-PVT 423
Cdd:COG2319  297 SPDGKLLASGSDDGTvRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTgAVT 376

                        170
                 ....*....|....*.
gi 768004085 424 CCDVSSNNRLVVTGSG 439
Cdd:COG2319  377 SVAFSPDGRTLASGSA 392
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 159-438 2.47e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 70.06  E-value: 2.47e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004085 159 ILAHGELVLATAISSFTRHVFTCGRRG-IKVWSLTGQVAEDRFpESHLpiqtpgAFLRTCLLSSNSRSLLTGGYNlASVS 237
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSGDGtIKVWDLETGELLRTL-KGHT------GPVRDVAASADGTYLASGSSD-KTIR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004085 238 VWDLAAPSLHVKEQLPCAGLNCqaLDANLDANLAFASFTSGVVRIWDLRDQSVVRDLKGYPDGVKSIVVKGYN--IWTGG 315
Cdd:cd00200   77 LWDLETGECVRTLTGHTSYVSS--VAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGtfVASSS 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004085 316 PDACLRCWDQRTiMKPLE--YQFKSQIMSLSHSPQEDWVLLGMANGQ--QWLQSTSGSQRHMVGQKDSViLSVKFSPFGQ 391
Cdd:cd00200  155 QDGTIKLWDLRT-GKCVAtlTGHTGEVNSVAFSPDGEKLLSSSSDGTikLWDLSTGKCLGTLRGHENGV-NSVAFSPDGY 232

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 768004085 392 WWASVGMDDFLGVYSMPAGTKVFEVPE-MSPVTCCDVSSNNRLVVTGS 438
Cdd:cd00200  233 LLASGSEDGTIRVWDLRTGECVQTLSGhTNSVTSLAWSPDGKRLASGS 280
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 261-439 1.08e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 65.43  E-value: 1.08e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004085 261 ALDANLDANLAFASFTSGVVRIWDLRDQSVVRDLKGYPDGVKSI--VVKGYNIWTGGPDACLRCWDQRTIMKPLEY-QFK 337
Cdd:cd00200   14 CVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVaaSADGTYLASGSSDKTIRLWDLETGECVRTLtGHT 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004085 338 SQIMSLSHSPQEDWVLLGMANGQQWLQSTSGSQRHMV--GQKDSViLSVKFSPFGQWWASVGMDDFLGVYSMPAGT--KV 413
Cdd:cd00200   94 SYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTlrGHTDWV-NSVAFSPDGTFVASSSQDGTIKLWDLRTGKcvAT 172

                        170       180
                 ....*....|....*....|....*.
gi 768004085 414 FEVPEmSPVTCCDVSSNNRLVVTGSG 439
Cdd:cd00200  173 LTGHT-GEVNSVAFSPDGEKLLSSSS 197
WD40 COG2319
WD40 repeat [General function prediction only];
270-439 3.99e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.55  E-value: 3.99e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004085 270 LAFASFtSGVVRIWDLRDQSVVRDLKGYPDGVKSIVV--KGYNIWTGGPDACLRCWDQRT--IMKPLEYQfKSQIMSLSH 345
Cdd:COG2319  219 LASGSA-DGTVRLWDLATGKLLRTLTGHSGSVRSVAFspDGRLLASGSADGTVRLWDLATgeLLRTLTGH-SGGVNSVAF 296

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004085 346 SPQEDWVLLGMANGQ-QWLQSTSGSQRHMVGQKDSVILSVKFSPFGQWWASVGMDDFLGVYSMPAGTKVFEVPEMS-PVT 423
Cdd:COG2319  297 SPDGKLLASGSDDGTvRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTgAVT 376

                        170
                 ....*....|....*.
gi 768004085 424 CCDVSSNNRLVVTGSG 439
Cdd:COG2319  377 SVAFSPDGRTLASGSA 392
WD40 COG2319
WD40 repeat [General function prediction only];
261-441 3.08e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 55.30  E-value: 3.08e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004085 261 ALDANLDANLAFASFTSGVVRIWDLRDQSVVRDLKGYPDGVKSIVV--KGYNIWTGGPDACLRCWDQRTimKPLEYQFK- 337
Cdd:COG2319   83 SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFspDGKTLASGSADGTVRLWDLAT--GKLLRTLTg 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004085 338 --SQIMSLSHSPQEDWVLLGMANGQQWL-QSTSGSQRHMVGQKDSVILSVKFSPFGQWWASVGMDDFLGVYSMPAGTKVF 414
Cdd:COG2319  161 hsGAVTSVAFSPDGKLLASGSDDGTVRLwDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLR 240

                        170       180
                 ....*....|....*....|....*...
gi 768004085 415 EVP-EMSPVTCCDVSSNNRLVVTGSGEH 441
Cdd:COG2319  241 TLTgHSGSVRSVAFSPDGRLLASGSADG 268
WD40 COG2319
WD40 repeat [General function prediction only];
270-399 3.78e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 48.75  E-value: 3.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004085 270 LAFASFtSGVVRIWDLRDQSVVRDLKGYPDGVKSIVV--KGYNIWTGGPDACLRCWD--QRTIMKPLEyQFKSQIMSLSH 345
Cdd:COG2319  261 LASGSA-DGTVRLWDLATGELLRTLTGHSGGVNSVAFspDGKLLASGSDDGTVRLWDlaTGKLLRTLT-GHTGAVRSVAF 338

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 768004085 346 SPQEDWVLLGMANGQQWL-QSTSGSQRHMVGQKDSVILSVKFSPFGQWWASVGMD 399
Cdd:COG2319  339 SPDGKTLASGSDDGTVRLwDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSAD 393
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 156-324 6.16e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 44.63  E-value: 6.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004085 156 KMRILAHGELVLATAISSFTRHVFTCGRRG-IKVWSLTGQVAEDRFpESHLpiqtpgAFLRTCLLSSNSRSLLTGGYNlA 234
Cdd:cd00200  128 LTTLRGHTDWVNSVAFSPDGTFVASSSQDGtIKLWDLRTGKCVATL-TGHT------GEVNSVAFSPDGEKLLSSSSD-G 199

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004085 235 SVSVWDLAAPSLHvkEQLPCAGLNCQALDANLDANLAFASFTSGVVRIWDLRDQSVVRDLKGYPDGVKSIVVKGYNIW-- 312
Cdd:cd00200  200 TIKLWDLSTGKCL--GTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRla 277

                        170
                 ....*....|..
gi 768004085 313 TGGPDACLRCWD 324
Cdd:cd00200  278 SGSADGTIRIWD 289
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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