|
Name |
Accession |
Description |
Interval |
E-value |
| recomb_DMC1 |
TIGR02238 |
meiotic recombinase Dmc1; This model describes DMC1, a subfamily of a larger family of DNA ... |
24-260 |
4.38e-137 |
|
meiotic recombinase Dmc1; This model describes DMC1, a subfamily of a larger family of DNA repair and recombination proteins. It is eukaryotic only and most closely related to eukaryotic RAD51. It also resembles archaeal RadA (TIGR02236) and RadB (TIGR02237) and bacterial RecA (TIGR02012). It has been characterized for human as a recombinase active only in meiosis.
Pssm-ID: 131292 [Multi-domain] Cd Length: 313 Bit Score: 389.91 E-value: 4.38e-137
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023194 24 IDLLQKHGINVADIKKLKSVGICTIKGIQMTTRRALCNVKGLSEAKVDKIKEAANKLIEPGFLTAFEYSEKRKMVFHITT 103
Cdd:TIGR02238 1 IDKLQAHGINAADIKKLKSAGICTVNGVIMTTRRALCKIKGLSEAKVDKIKEAASKIINPGFITAFEISQKRKKVLKITT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023194 104 GSQEFDKLLGGGIESMAITEAFG--------------------------------------------------------- 126
Cdd:TIGR02238 81 GSQALDGILGGGIESMSITEVFGefrcgktqlshtlcvtaqlpremgggngkvayidtegtfrpdriraiaerfgvdpda 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023194 127 ------------GEHQMELLDYVAAKFHEEagIFKLLIIDSIMALFRVDFSGRGELAERQQKLAQMLSRLQKISEEYNVA 194
Cdd:TIGR02238 161 vldnilyaraytSEHQMELLDYLAAKFSEE--PFRLLIVDSIMALFRVDFSGRGELSERQQKLAQMLSRLNKISEEFNVA 238
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 768023194 195 VFVTNQMTADPGATMTFQADPKKPIGGHILAHASTTRISLRKGRGELRIAKIYDRLSEREQKASVK 260
Cdd:TIGR02238 239 VFVTNQVQADPGATMTFIADPKKPIGGHVLAHASTTRILLRKGRGEERVAKLYDSPDMPEAEASFQ 304
|
|
| PTZ00035 |
PTZ00035 |
Rad51 protein; Provisional |
15-248 |
1.26e-123 |
|
Rad51 protein; Provisional
Pssm-ID: 185407 [Multi-domain] Cd Length: 337 Bit Score: 356.62 E-value: 1.26e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023194 15 DEEESLFQDIDLLQKHGINVADIKKLKSVGICTIKGIQMTTRRALCNVKGLSEAKVDKIKEAANKLIEPGFLTAFEYSEK 94
Cdd:PTZ00035 14 EEEAEGFQEIEKLQSAGINAADIKKLKEAGICTVESVAYATKKDLCNIKGISEAKVEKIKEAASKLVPMGFISATEYLEA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023194 95 RKMVFHITTGSQEFDKLLGGGIESMAITEAFG------------------------------------------------ 126
Cdd:PTZ00035 94 RKNIIRITTGSTQLDKLLGGGIETGSITELFGefrtgktqlchtlcvtcqlpieqgggegkvlyidtegtfrperivqia 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023194 127 ---------------------GEHQMELLDYVAAKFHEEAgiFKLLIIDSIMALFRVDFSGRGELAERQQKLAQMLSRLQ 185
Cdd:PTZ00035 174 erfgldpedvldniayaraynHEHQMQLLSQAAAKMAEER--FALLIVDSATALFRVDYSGRGELAERQQHLGKFLRALQ 251
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 768023194 186 KISEEYNVAVFVTNQMTADPGATMTFQADPKKPIGGHILAHASTTRISLRKGRGELRIAKIYD 248
Cdd:PTZ00035 252 KLADEFNVAVVITNQVMADVDGASMFVADPKKPIGGHIIAHASTTRLSLRKGRGEQRICKIYD 314
|
|
| PLN03187 |
PLN03187 |
meiotic recombination protein DMC1 homolog; Provisional |
15-258 |
5.51e-103 |
|
meiotic recombination protein DMC1 homolog; Provisional
Pssm-ID: 215620 [Multi-domain] Cd Length: 344 Bit Score: 304.39 E-value: 5.51e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023194 15 DEEESLFQDIDLLQKHGINVADIKKLKSVGICTIKGIQMTTRRALCNVKGLSEAKVDKIKEAANKLIEPGFLTAFEYSEK 94
Cdd:PLN03187 22 DEEEDLFESIDKLISQGINAGDVKKLQDAGIYTCNGLMMHTKKNLTGIKGLSEAKVDKICEAAEKLLNQGFITGSDALLK 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023194 95 RKMVFHITTGSQEFDKLLGGGIESMAITEAFGG----------------------------------------------- 127
Cdd:PLN03187 102 RKSVVRITTGSQALDELLGGGIETRCITEAFGEfrsgktqlahtlcvttqlptemgggngkvayidtegtfrpdrivpia 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023194 128 ----------------------EHQMELLDYVAAKFHEEAgiFKLLIIDSIMALFRVDFSGRGELAERQQKLAQMLSRLQ 185
Cdd:PLN03187 182 erfgmdadavldniiyaraytyEHQYNLLLGLAAKMAEEP--FRLLIVDSVIALFRVDFTGRGELAERQQKLAQMLSRLT 259
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 768023194 186 KISEEYNVAVFVTNQMTADPGAtMTFQADPKKPIGGHILAHASTTRISLRKGRGELRIAKIYDRLSEREQKAS 258
Cdd:PLN03187 260 KIAEEFNVAVYMTNQVIADPGG-GMFISDPKKPAGGHVLAHAATIRLMLRKGKGEQRVCKVFDAPNLPEAEAE 331
|
|
| DMC1 |
cd19514 |
homologous-pairing protein DMC1; DMC1 has a central role in homologous recombination in ... |
101-258 |
1.79e-102 |
|
homologous-pairing protein DMC1; DMC1 has a central role in homologous recombination in meiosis. It assembles at the sites of programmed DNA double-strand breaks and carries out a search for allelic DNA sequences located on homologous chromatids. It forms octameric rings.
Pssm-ID: 410922 [Multi-domain] Cd Length: 236 Bit Score: 298.89 E-value: 1.79e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023194 101 ITTGSQEFDKLLGGGIESMAITEAFG------------------------------------------------------ 126
Cdd:cd19514 1 ISTGSTELDKLLGGGIESMSITEVFGefrtgktqlshtlcvtaqlpgsmgggggkvayidtegtfrpdrirpiaerfgvd 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023194 127 ---------------GEHQMELLDYVAAKFHEEAgIFKLLIIDSIMALFRVDFSGRGELAERQQKLAQMLSRLQKISEEY 191
Cdd:cd19514 81 hdavldnilyaraytSEHQMELLDYVAAKFHEEA-VFRLLIIDSIMALFRVDFSGRGELAERQQKLAQMLSRLQKISEEY 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 768023194 192 NVAVFVTNQMTADPGATMTFQADPKKPIGGHILAHASTTRISLRKGRGELRIAKIYDRLSEREQKAS 258
Cdd:cd19514 160 NVAVFITNQVTADPGAAMTFQADPKKPIGGHILAHASTTRISLRKGRGEERIAKIYDSPDLPENEAT 226
|
|
| recomb_RAD51 |
TIGR02239 |
DNA repair protein RAD51; This eukaryotic sequence family consists of RAD51, a protein ... |
24-267 |
2.75e-87 |
|
DNA repair protein RAD51; This eukaryotic sequence family consists of RAD51, a protein involved in DNA homologous recombination and repair. It is similar in sequence the exclusively meiotic recombinase DMC1 (TIGR02238), to archaeal families RadA (TIGR02236) and RadB (TIGR02237), and to bacterial RecA (TIGR02012).
Pssm-ID: 274048 [Multi-domain] Cd Length: 316 Bit Score: 263.51 E-value: 2.75e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023194 24 IDLLQKHGINVADIKKLKSVGICTIKGIQMTTRRALCNVKGLSEAKVDKIKEAANKLIEPGFLTAFEYSEKRKMVFHITT 103
Cdd:TIGR02239 1 IEKLEGNGITAADIKKLQEAGLHTVESVAYAPKKQLLEIKGISEAKADKILAEAAKLVPMGFTTATEFHQRRQEVIQLTT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023194 104 GSQEFDKLLGGGIESMAITEAFG-------------------------GE------------------------------ 128
Cdd:TIGR02239 81 GSKELDKLLGGGIETGSITEIFGefrtgktqlchtlavtcqlpidqggGEgkalyidtegtfrperllaiaeryglnped 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023194 129 --------------HQMELLDYVAAKFHEEAgiFKLLIIDSIMALFRVDFSGRGELAERQQKLAQMLSRLQKISEEYNVA 194
Cdd:TIGR02239 161 vldnvayarayntdHQLQLLQQAAAMMSESR--FALLIVDSATALYRTDFSGRGELSARQMHLARFLRSLQRLADEFGVA 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 768023194 195 VFVTNQMTADP-GATMTFQADPKKPIGGHILAHASTTRISLRKGRGELRIAKIYDR--LSEREQKASVKT--IKDPEE 267
Cdd:TIGR02239 239 VVITNQVVAQVdGAGSMFAGDPKKPIGGNIMAHASTTRLSLRKGRGEQRICKIYDSpcLPESEAMFAIYEdgIGDPKE 316
|
|
| PLN03186 |
PLN03186 |
DNA repair protein RAD51 homolog; Provisional |
1-261 |
1.08e-84 |
|
DNA repair protein RAD51 homolog; Provisional
Pssm-ID: 178728 [Multi-domain] Cd Length: 342 Bit Score: 257.74 E-value: 1.08e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023194 1 MKEDQVVAEEPGFQDEEESL-FQDIDLLQKHGINVADIKKLKSVGICTIKGIQMTTRRALCNVKGLSEAKVDKIKEAANK 79
Cdd:PLN03186 4 AVAAAAAQAMQEEEEEEAAHgPFPIEQLQASGIAALDIKKLKDAGIHTVESLAYAPKKDLLQIKGISEAKVEKILEAASK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023194 80 LIEPGFLTAFEYSEKRKMVFHITTGSQEFDKLLGGGIESMAITEAFG--------------------------------- 126
Cdd:PLN03186 84 LVPLGFTTASQLHAQRQEIIQITTGSRELDKILEGGIETGSITEIYGefrtgktqlchtlcvtcqlpldqgggegkamyi 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023194 127 ------------------------------------GEHQMELLDYVAAKFHEEAgiFKLLIIDSIMALFRVDFSGRGEL 170
Cdd:PLN03186 164 dtegtfrpqrliqiaerfglngadvlenvayaraynTDHQSELLLEAASMMAETR--FALMIVDSATALYRTEFSGRGEL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023194 171 AERQQKLAQMLSRLQKISEEYNVAVFVTNQMTADPGAtMTFQADPK-KPIGGHILAHASTTRISLRKGRGELRIAKIYDR 249
Cdd:PLN03186 242 SARQMHLGKFLRSLQRLADEFGVAVVITNQVVAQVDG-SAFFAGPQlKPIGGNIMAHASTTRLALRKGRGENRICKVISS 320
|
330
....*....|....
gi 768023194 250 --LSEREQKASVKT 261
Cdd:PLN03186 321 pcLPEAEARFSISS 334
|
|
| Rad51 |
pfam08423 |
Rad51; Rad51 is a DNA repair and recombination protein and is a homolog of the bacterial ... |
84-254 |
1.89e-81 |
|
Rad51; Rad51 is a DNA repair and recombination protein and is a homolog of the bacterial ATPase RecA protein.
Pssm-ID: 462471 [Multi-domain] Cd Length: 255 Bit Score: 246.44 E-value: 1.89e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023194 84 GFLTAFEYSEKRKMVFHITTGSQEFDKLLGGGIESMAITEAFG------------------------------------- 126
Cdd:pfam08423 2 GFTTATELHQRRSELIQITTGSKELDKLLGGGIETGSITEIFGefrtgktqlchtlcvtcqlplemgggegkalyidteg 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023194 127 --------------------------------GEHQMELLDYVAAKFHEEAgiFKLLIIDSIMALFRVDFSGRGELAERQ 174
Cdd:pfam08423 82 tfrperlvaiaerygldpedvldnvayaraynSEHQMQLLQQAAAMMSESR--FALLIVDSATALYRTDFSGRGELAERQ 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023194 175 QKLAQMLSRLQKISEEYNVAVFVTNQMTADP-GATMTFQADPKKPIGGHILAHASTTRISLRKGRGELRIAKIYDR--LS 251
Cdd:pfam08423 160 QHLAKFLRTLQRLADEFGVAVVITNQVVAQVdGAAGMFSGDPKKPIGGHIMAHASTTRLSLRKGRGEQRICKIYDSpcLP 239
|
...
gi 768023194 252 ERE 254
Cdd:pfam08423 240 ESE 242
|
|
| Rad51_DMC1_archRadA |
cd01123 |
recombinase Rad51, DMC1, and archaeal RadA; This group of recombinases includes the eukaryotic ... |
101-248 |
2.84e-80 |
|
recombinase Rad51, DMC1, and archaeal RadA; This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal protein RadA. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a similar recombination reaction as RecA, using ATP-dependent DNA binding activity and a DNA-dependent ATPase. However, this reaction is less efficient and requires accessory proteins such as RAD55/57 .
Pssm-ID: 410868 [Multi-domain] Cd Length: 234 Bit Score: 242.44 E-value: 2.84e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023194 101 ITTGSQEFDKLLGGGIESMAITEAFG------------------------------------------------------ 126
Cdd:cd01123 1 ITTGSKELDKLLGGGIETGSITEMFGefrtgktqlchtlavtcqlpidrgggegkaiyidtegtfrperlraiaqrfgld 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023194 127 ---------------GEHQMELLDYVAAKFHEEagIFKLLIIDSIMALFRVDFSGRGELAERQQKLAQMLSRLQKISEEY 191
Cdd:cd01123 81 pddvldnvayarafnSDHQTQLLDQAAAMMVES--RFKLLIVDSATALYRTDYSGRGELSARQMHLAKFLRMLQRLADEF 158
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 768023194 192 NVAVFVTNQMTADPGATMTFQADPKKPIGGHILAHASTTRISLRKGRGELRIAKIYD 248
Cdd:cd01123 159 GVAVVVTNQVVAQVDGAMMFAADPKKPIGGNILAHASTTRLYLRKGRGETRICKIYD 215
|
|
| Rad51 |
cd19513 |
RAD51D recombinase; RAD51 recombinase plays an essential role in DNA repair by homologous ... |
101-254 |
6.47e-66 |
|
RAD51D recombinase; RAD51 recombinase plays an essential role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51 is recruited to the break site with the help of its paralogs, RAD51D, RAD51B, RAD51C, XRCC3, and XRCC2, where it forms long helical polymers which wrap around the ssDNA tail at the break which leads to pairing and strand invasion.
Pssm-ID: 410921 [Multi-domain] Cd Length: 235 Bit Score: 206.01 E-value: 6.47e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023194 101 ITTGSQEFDKLLGGGIESMAITEAFG-------------------------GE--------------------------- 128
Cdd:cd19513 1 ITTGSKELDKLLGGGIETGSITELFGefrtgktqlchtlavtcqlpidqggGEgkalyidtegtfrperllaiaerygln 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023194 129 -----------------HQMELLDYVAAKFHEEAgiFKLLIIDSIMALFRVDFSGRGELAERQQKLAQMLSRLQKISEEY 191
Cdd:cd19513 81 gedvldnvayarayntdHQMQLLIQASAMMAESR--YALLIVDSATALYRTDYSGRGELSARQMHLAKFLRMLQRLADEF 158
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 768023194 192 NVAVFVTNQMTADPGATMTFQADPKKPIGGHILAHASTTRISLRKGRGELRIAKIYDR--LSERE 254
Cdd:cd19513 159 GVAVVITNQVVAQVDGAAMFAGDPKKPIGGNIMAHASTTRLYLRKGRGETRICKIYDSpcLPEAE 223
|
|
| radA |
PRK04301 |
DNA repair and recombination protein RadA; Validated |
23-265 |
4.56e-64 |
|
DNA repair and recombination protein RadA; Validated
Pssm-ID: 235273 [Multi-domain] Cd Length: 317 Bit Score: 203.96 E-value: 4.56e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023194 23 DIDLLQKHGINVADIKKLKSVGICTIKGIQMTTRRALCNVKGLSEAKVDKIKEAANKLIE-PGFLTAFEYSEKRKMVFHI 101
Cdd:PRK04301 5 EKDLEDLPGVGPATAEKLREAGYDTVEAIAVASPKELSEAAGIGESTAAKIIEAAREAADiGGFETALEVLERRKNVGKI 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023194 102 TTGSQEFDKLLGGGIESMAITEAFG----GE----HQM------------------------------------------ 131
Cdd:PRK04301 85 TTGSKELDELLGGGIETQSITEFYGefgsGKtqicHQLavnvqlpeekgglegkavyidtegtfrperieqmaealgldp 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023194 132 -ELLD--YVAAKF---H-----EEAGIF-------KLLIIDSIMALFRVDFSGRGELAERQQKLAQMLSRLQKISEEYNV 193
Cdd:PRK04301 165 dEVLDniHVARAYnsdHqmllaEKAEELikegeniKLVIVDSLTAHFRAEYVGRGNLAERQQKLNKHLHDLLRLADLYNA 244
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 768023194 194 AVFVTNQMTADPGAtmtFQADPKKPIGGHILAHASTTRISLRKGRGELRIAKIYD--RLSEREQKASVKT--IKDP 265
Cdd:PRK04301 245 AVVVTNQVMARPDA---FFGDPTQPIGGHILGHTATFRIYLRKSKGNKRIARLVDspHLPEGEAVFRITEegIRDA 317
|
|
| recomb_radA |
TIGR02236 |
DNA repair and recombination protein RadA; This family consists exclusively of archaeal RadA ... |
31-248 |
1.13e-59 |
|
DNA repair and recombination protein RadA; This family consists exclusively of archaeal RadA protein, a homolog of bacterial RecA (TIGR02012), eukaryotic RAD51 (TIGR02239), and archaeal RadB (TIGR02237). This protein is involved in DNA repair and recombination. The member from Pyrococcus horikoshii contains an intein. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 131290 [Multi-domain] Cd Length: 310 Bit Score: 192.65 E-value: 1.13e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023194 31 GINVADIKKLKSVGICTIKGIQMTTRRALCNVKGLSEAKVDKIKEAANKLIEPG-FLTAFEYSEKRKMVFHITTGSQEFD 109
Cdd:TIGR02236 6 GVGPATAEKLREAGYDTFEAIAVASPKELSEIAGISEGTAAKIIQAARKAADLGgFETADDVLERRKTIGKITTGSKELD 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023194 110 KLLGGGIESMAITEAFG--------------------------------------------------------------- 126
Cdd:TIGR02236 86 ELLGGGIETQAITEVFGefgsgktqichqlavnvqlpeekgglggkavyidtentfrperimqmaeargldpdevlkniy 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023194 127 ------GEHQMELLDYVAAKFHEEAGIFKLLIIDSIMALFRVDFSGRGELAERQQKLAQMLSRLQKISEEYNVAVFVTNQ 200
Cdd:TIGR02236 166 varaynSNHQMLLVEKAEDLIKELNNPVKLLIVDSLTSHFRAEYVGRGALAERQQKLNKHLHDLLRLADLYNAAVVVTNQ 245
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 768023194 201 MTADPGAtmtFQADPKKPIGGHILAHASTTRISLRKGRGELRIAKIYD 248
Cdd:TIGR02236 246 VMARPDA---FFGDPTRPIGGHILGHAATFRVYLRKGKGDKRIARLVD 290
|
|
| archRadA |
cd19515 |
archaeal recombinase Rad51/RadA; This group includes the archaeal protein RadA which is a ... |
101-254 |
8.57e-49 |
|
archaeal recombinase Rad51/RadA; This group includes the archaeal protein RadA which is a homolog of Rad51. RAD51 recombinase plays an essential role in DNA repair by homologous recombination (HR)
Pssm-ID: 410923 [Multi-domain] Cd Length: 233 Bit Score: 162.15 E-value: 8.57e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023194 101 ITTGSQEFDKLLGGGIESMAITEAFG----GE----HQM----------------------------------------- 131
Cdd:cd19515 1 ISTGSKELDKLLGGGIETQAITEVFGefgsGKtqlcHQLavnvqlppeegglngkavyidtentfrperimqmakalgld 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023194 132 --ELLD--YVAAKFH---------------EEAGIFKLLIIDSIMALFRVDFSGRGELAERQQKLAQMLSRLQKISEEYN 192
Cdd:cd19515 81 pdEVLDniYVARAYNsnhqmllvekaedliKEGNNIKLLIVDSLTSHFRAEYVGRGTLAERQQKLNKHLHDLHRLADLYN 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 768023194 193 VAVFVTNQMTADPGAtmtFQADPKKPIGGHILAHASTTRISLRKGRGELRIAKIYD--RLSERE 254
Cdd:cd19515 161 IAVLVTNQVMAKPDA---FFGDPTQAIGGHILGHAATFRVYLRKGKGGKRIARLVDspHLPEGE 221
|
|
| RecA-like |
cd01393 |
RecA family; RecA is a bacterial enzyme which has roles in homologous recombination, DNA ... |
88-236 |
2.77e-23 |
|
RecA family; RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange. While prokaryotes have a single RecA protein, eukaryotes have multiple RecA homologs such as Rad51, DMC1 and Rad55/57. Archaea have the RecA-like homologs RadA and RadB.
Pssm-ID: 410881 [Multi-domain] Cd Length: 185 Bit Score: 93.96 E-value: 2.77e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023194 88 AFEYSEKRKMVFHITTGSQEFDKLLgggiESMAITEAFGGEHQMELLDYvaakfHEEAGI----FKLLIIDSIMALFRVD 163
Cdd:cd01393 40 AFPPSRLVQILEASPSSELELAEAL----SRLLYFRPPDTLAHLLALDS-----LPESLFpppnTSLVVVDSVSALFRKA 110
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 768023194 164 F----SGRGELAERQQKLAQMLSRLQKISEEYNVAVFVTNQMTADPGAtmTFQADPKKPIGGHILAHASTTRISLRK 236
Cdd:cd01393 111 FprggDGDSSSSLRARLLSQLARALQKLAAQFNLAVVVTNQVTTKIRG--GSGASLVPPALGNTWEHSVSTRLLLYR 185
|
|
| radB |
PRK09361 |
DNA repair and recombination protein RadB; Provisional |
97-254 |
7.51e-18 |
|
DNA repair and recombination protein RadB; Provisional
Pssm-ID: 236482 [Multi-domain] Cd Length: 225 Bit Score: 80.29 E-value: 7.51e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023194 97 MVFHITTGSQEFDKLLGGGIESMAITEAFG-----------------------------------------GEHQMELLD 135
Cdd:PRK09361 1 MDERLPTGCKMLDELLGGGFERGTITQIYGppgsgktniclqlaveaakngkkviyidteglsperfkqiaGEDFEELLS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023194 136 ----YVAAKFHEEAGI-----------FKLLIIDSIMALFRVDFSGRGELAERQQKLAQMLSRLQKISEEYNVAVFVTNQ 200
Cdd:PRK09361 81 niiiFEPSSFEEQSEAirkaeklakenVGLIVLDSATSLYRLELEDEEDNSKLNRELGRQLTHLLKLARKHDLAVVITNQ 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 768023194 201 MTADPGATMTfqadpkKPIGGHILAHASTTRISLRKGRGELRIAKIYDRLSERE 254
Cdd:PRK09361 161 VYSDIDSDGL------RPLGGHTLEHWSKTILRLEKFRNGKRRATLEKHRSRPE 208
|
|
| Rad51B |
cd19493 |
RAD51B recombinase; RAD51B recombinase, a RAD51 paralog, plays an important role in DNA repair ... |
149-245 |
3.86e-17 |
|
RAD51B recombinase; RAD51B recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51B, together with the other RAD51 paralogs, RAD51C, RAD51D, XRCC3, and XRCC2, helps recruit RAD51 to the break site.
Pssm-ID: 410901 [Multi-domain] Cd Length: 222 Bit Score: 78.13 E-value: 3.86e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023194 149 KLLIIDSIMALFRVDFSG-RGELAERQQKLAQMLSRLQKISEEYNVAVFVTNQMTADPGATMTFQADPKKPIgGHILAHA 227
Cdd:cd19493 119 RLVVIDSIAALVRREFGGsDGEVTERHNALAREASSLKRLAEEFRIAVLVTNQATTHFGDAGDGSSGVTAAL-GDAWAHA 197
|
90 100
....*....|....*....|..
gi 768023194 228 STTRISLRKGRGELR----IAK 245
Cdd:cd19493 198 VNTRLRLERCLLQLRrvleIVK 219
|
|
| archRadB |
cd01394 |
archaeal RadB; The archaeal protein RadB shares similarity RadA, the archaeal functional ... |
101-246 |
8.78e-17 |
|
archaeal RadB; The archaeal protein RadB shares similarity RadA, the archaeal functional homologue to the bacterial RecA. The precise function of RadB is unclear.
Pssm-ID: 410882 [Multi-domain] Cd Length: 216 Bit Score: 77.35 E-value: 8.78e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023194 101 ITTGSQEFDKLLGGGIESMAITEAFG-----------------------------------------GEHQMELLDYV-- 137
Cdd:cd01394 1 LSTGSKSLDSLLGGGVERGTITQIYGppgsgktniclqlaveaakqgkkvvyidteglsperfqqiaGERFESIASNIiv 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023194 138 --AAKFHEEA------------GIFKLLIIDSIMALFRVDfsgRGELAERQQKLAQMLSRLQKISEEYNVAVFVTNQMTA 203
Cdd:cd01394 81 fePYSFDEQGvaiqeaekllksDKVDLVVVDSATALYRLE---LGDDSEANRELSRQMSKLLSIARKYDIPVVITNQVYS 157
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 768023194 204 DpgatmtFQADPKKPIGGHILAHASTTRISLRKGRGELRIAKI 246
Cdd:cd01394 158 D------IDDDRLKPVGGTLLEHWSKAIIRLEKSPPGLRRATL 194
|
|
| XRCC3 |
cd19491 |
XRCC3 recombinase; XRCC3 (X-ray repair complementing defective repair in Chinese hamster cells ... |
128-236 |
1.67e-15 |
|
XRCC3 recombinase; XRCC3 (X-ray repair complementing defective repair in Chinese hamster cells 3) recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. XRCC3, together with the other RAD51 paralogs, RAD51B, RAD51C, RAD51D, and XRCC2, helps recruit RAD51 to the break site.
Pssm-ID: 410899 [Multi-domain] Cd Length: 250 Bit Score: 74.25 E-value: 1.67e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023194 128 EHQMELLDYVAAKFHEEAGIfKLLIIDSIMALFRVDF-SGRGELAERQQKLAQMLSRLQKISEEYNVAVFVTNQMTADPG 206
Cdd:cd19491 95 ETLEHCLNYQLPALLERGPI-RLVVIDSIAALFRSEFdTSRSDLVERAKYLRRLADHLKRLADKYNLAVVVVNQVTDRFD 173
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 768023194 207 A---------------TMTFQADP----KKPIGGHILAHASTTRISLRK 236
Cdd:cd19491 174 SssdasglgvldylsqFSSFSGGVsgnrKVPALGLTWANLVNTRLMLSR 222
|
|
| Rad51C |
cd19492 |
RAD51C recombinase; RAD51C recombinase, a RAD51 paralog, plays an important role in DNA repair ... |
130-247 |
1.79e-12 |
|
RAD51C recombinase; RAD51C recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51C, together with the other RAD51 paralogs, RAD51B, RAD51D, XRCC3, and XRCC2, helps recruit RAD51 to the break site. Additionally, RAD51C acts as a mediator in the early steps of DNA damage signaling.
Pssm-ID: 410900 [Multi-domain] Cd Length: 172 Bit Score: 64.17 E-value: 1.79e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023194 130 QMELLDYVAAKFHEEAGIfKLLIIDSIMALFRVDFSGrgeLAERQQKLAQMLSRLQKISEEYNVAVFVTNQMTADPGATM 209
Cdd:cd19492 60 LLALINSLPKFLEDHPKV-KLIVVDSIAFPFRHDFDD---LAQRTRLLNGLAQLLHSLARQHNLAVVLTNQVTTKISEDG 135
|
90 100 110
....*....|....*....|....*....|....*...
gi 768023194 210 TFQAdpkKPIGGHILAHASTTRISLRKGRGElRIAKIY 247
Cdd:cd19492 136 QSQL---VPALGESWSHACTTRLFLTWDEKQ-RFAHLY 169
|
|
| RecA |
COG0468 |
RecA/RadA recombinase [Replication, recombination and repair]; |
112-237 |
4.53e-07 |
|
RecA/RadA recombinase [Replication, recombination and repair];
Pssm-ID: 440236 [Multi-domain] Cd Length: 351 Bit Score: 50.55 E-value: 4.53e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023194 112 LGGGIESMAITEAFGGEHQMELLDYVAakfheEAGIFKLLIIDSIMALF-RVDFSGR---GELAERQQKLAQMLSRLQKI 187
Cdd:COG0468 111 LGVDIDNLLVSQPDTGEQALEIAETLV-----RSGAVDLIVVDSVAALVpKAEIEGEmgdSHVGLQARLMSQALRKLTGA 185
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 768023194 188 SEEYNVAVFVTNQMTADPGatMTFqADPKKPIGGHILAHASTTRISLRKG 237
Cdd:COG0468 186 ISKSNTTVIFINQLREKIG--VMF-GNPETTTGGNALKFYASVRLDIRRI 232
|
|
| Rad51D |
cd19489 |
RAD51D recombinase; RAD51D recombinase, a RAD51 paralog, plays an important role in DNA repair ... |
148-236 |
6.04e-06 |
|
RAD51D recombinase; RAD51D recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51D, together with the other RAD51 paralogs, RAD51B, RAD51C, XRCC3, and XRCC2, helps recruit RAD51 to the break site.
Pssm-ID: 410897 [Multi-domain] Cd Length: 209 Bit Score: 46.09 E-value: 6.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023194 148 FKLLIIDSIMALFRVDFSGrgelAERQQKLAQM--LSR-LQKISEEYNVAVFVTNQMTADPGatMTFQADPkKPIGGHIL 224
Cdd:cd19489 107 LKLVIIDSLSALISPLLGG----SKHSEGHALLasLARlLKKLAAEYQIAVLVTNLTVRGGD--GGQQGST-KPALGEYW 179
|
90
....*....|..
gi 768023194 225 AHASTTRISLRK 236
Cdd:cd19489 180 ESVPSTRLLLSR 191
|
|
| HHH_5 |
pfam14520 |
Helix-hairpin-helix domain; |
25-79 |
7.58e-05 |
|
Helix-hairpin-helix domain;
Pssm-ID: 434010 [Multi-domain] Cd Length: 57 Bit Score: 39.78 E-value: 7.58e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 768023194 25 DLLQKHGINVADIKKLKSVGICTIKGIQMTTRRALCNVKGLSEAKVDKIKEAANK 79
Cdd:pfam14520 3 ELLSISGIGPKTALALLSAGIGTVEDLAEADVDELAEIPGIGEKTAQRIILELRD 57
|
|
| XRCC2 |
cd19490 |
XRCC2 recombinase; XRCC2 (X-ray repair complementing defective repair in Chinese hamster cells ... |
150-236 |
1.54e-04 |
|
XRCC2 recombinase; XRCC2 (X-ray repair complementing defective repair in Chinese hamster cells 2) recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. XRCC2, together with the other RAD51 paralogs, RAD51B, RAD51C, RAD51D, and XRCC3, helps recruit RAD51 to the break site.
Pssm-ID: 410898 [Multi-domain] Cd Length: 226 Bit Score: 41.95 E-value: 1.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768023194 150 LLIIDSIMALFRVDFSGRGELAERQQK----LAQMLSRLQKISEEYNVAVFVTNQM-----------TADPGATMTFQAD 214
Cdd:cd19490 125 LLLIDSISAFYWQDRFSAELARAAPLLqeaaLRAILRELRRLRRRFQLVVIATKQAlfpgksastdnPAANNAVSKASAP 204
|
90 100
....*....|....*....|..
gi 768023194 215 PKKPIGGHILAHASTTRISLRK 236
Cdd:cd19490 205 SHREYLPRPWQRLVTHRLVLSR 226
|
|
| |
