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Conserved domains on  [gi|768024611|ref|XP_011528435|]
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glutathione hydrolase 5 proenzyme isoform X1 [Homo sapiens]

Protein Classification

gamma-glutamyltransferase family protein( domain architecture ID 10470232)

gamma-glutamyltransferase family protein exhibits gamma-glutamyltranspeptidase and/or cephalosporin acylase and/or glutathione hydrolase activity, all involving the hydrolytic splitting of a peptide-like C-N bond

EC:  3.-.-.-
Gene Ontology:  GO:0016787
MEROPS:  T3
PubMed:  11563810|22527720
SCOP:  4000420

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
G_glu_transpept pfam01019
Gamma-glutamyltranspeptidase;
58-618 0e+00

Gamma-glutamyltranspeptidase;


:

Pssm-ID: 425991  Cd Length: 499  Bit Score: 563.76  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611   58 RAILQQQGSPVDATIAALVCTSVVNPQSMGLGGGVIFTIYNVTTGKVEVINARETVPASHAPSLLDQCAQALPLGTGAQW 137
Cdd:pfam01019   1 LDILRKGGNAVDAAVAAALCLGVVEPHSSGIGGGGFMLIYDAKTGKVLVIDARETAPAAATKDMFDGKGDSKLSLTGGLA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611  138 IGVPGELRGYAEAHRRHGRLPWAQLFQPTIALLRGGHVVAPVLSRFLHNSILRPsLQASTLRQLFFNGTEPLRPQDPLPW 217
Cdd:pfam01019  81 VGVPGEVAGLAEAHKRYGRLPWADLLEPAIKLARDGFPVSPALARALARAEERL-RADPGLRKIFLPTGRVLKAGELLKQ 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611  218 PALATTLETVATEGVEVFYTGRLGQMLVEDIAKEGSQLTLQDLAKFQPEVVDALEVPLGDYTLYSPPPPAGGAILSFILN 297
Cdd:pfam01019 160 PALAKTLELIAEEGPDAFYRGELAQQLVADLQANGGIITAEDLANYRVKIREPLSADYGGYTVYSPPPSSGGIALLQILN 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611  298 VLRGFNFSTESmarpeGRVNVYHHLVETLKFAKGQRWR-LGDPRSHPKLQnasRDLLGETLAQLIRQQIDGRGDHQLSHy 376
Cdd:pfam01019 240 ILEGFDLSSLL-----NSAEYLHLLIEAMKLAYADRTRyLGDPDFVPVPV---ENLLSPEYAKERAKLINPNAAFPSSY- 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611  377 slaeaWGHGTGTSHVSVLGEDGSAVAATSTINTPFGAMVYSPRTGIILNNELLDLCERCPRGSGTTPSPDAvcsavsgdr 456
Cdd:pfam01019 311 -----APEDGGTTHFSVVDRDGNAVSFTSTINLGFGSGVVVPGTGILLNNEMDDFSTPPGNAFGLDPSPAN--------- 376
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611  457 vggapgrcwPPVPGERSPSSMVPSILINKaQGSKLVIGGAGGELIISAVAQAIMSKLWLGFDLRAAIAAPILHVNSKGCV 536
Cdd:pfam01019 377 ---------AIAPGKRPLSSMAPTIVLDD-GKPVLVVGAPGGSRIISAVLQVIVNVLDLGLDLQQAVDAPRIHHQLPDVL 446
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611  537 EYEPNFSqkqdlaalprlvsnswpqvillpqppkllalQEVQRGLQDRGQNQTQRPFFLNVVQAVSQ--EGACVYAVSDL 614
Cdd:pfam01019 447 EVEPGFP-------------------------------EEVLAELEARGHKVKVVEDSSSVGAIQIVrrTGGVLYAASDP 495

                  ....
gi 768024611  615 RKSG 618
Cdd:pfam01019 496 RRDG 499
 
Name Accession Description Interval E-value
G_glu_transpept pfam01019
Gamma-glutamyltranspeptidase;
58-618 0e+00

Gamma-glutamyltranspeptidase;


Pssm-ID: 425991  Cd Length: 499  Bit Score: 563.76  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611   58 RAILQQQGSPVDATIAALVCTSVVNPQSMGLGGGVIFTIYNVTTGKVEVINARETVPASHAPSLLDQCAQALPLGTGAQW 137
Cdd:pfam01019   1 LDILRKGGNAVDAAVAAALCLGVVEPHSSGIGGGGFMLIYDAKTGKVLVIDARETAPAAATKDMFDGKGDSKLSLTGGLA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611  138 IGVPGELRGYAEAHRRHGRLPWAQLFQPTIALLRGGHVVAPVLSRFLHNSILRPsLQASTLRQLFFNGTEPLRPQDPLPW 217
Cdd:pfam01019  81 VGVPGEVAGLAEAHKRYGRLPWADLLEPAIKLARDGFPVSPALARALARAEERL-RADPGLRKIFLPTGRVLKAGELLKQ 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611  218 PALATTLETVATEGVEVFYTGRLGQMLVEDIAKEGSQLTLQDLAKFQPEVVDALEVPLGDYTLYSPPPPAGGAILSFILN 297
Cdd:pfam01019 160 PALAKTLELIAEEGPDAFYRGELAQQLVADLQANGGIITAEDLANYRVKIREPLSADYGGYTVYSPPPSSGGIALLQILN 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611  298 VLRGFNFSTESmarpeGRVNVYHHLVETLKFAKGQRWR-LGDPRSHPKLQnasRDLLGETLAQLIRQQIDGRGDHQLSHy 376
Cdd:pfam01019 240 ILEGFDLSSLL-----NSAEYLHLLIEAMKLAYADRTRyLGDPDFVPVPV---ENLLSPEYAKERAKLINPNAAFPSSY- 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611  377 slaeaWGHGTGTSHVSVLGEDGSAVAATSTINTPFGAMVYSPRTGIILNNELLDLCERCPRGSGTTPSPDAvcsavsgdr 456
Cdd:pfam01019 311 -----APEDGGTTHFSVVDRDGNAVSFTSTINLGFGSGVVVPGTGILLNNEMDDFSTPPGNAFGLDPSPAN--------- 376
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611  457 vggapgrcwPPVPGERSPSSMVPSILINKaQGSKLVIGGAGGELIISAVAQAIMSKLWLGFDLRAAIAAPILHVNSKGCV 536
Cdd:pfam01019 377 ---------AIAPGKRPLSSMAPTIVLDD-GKPVLVVGAPGGSRIISAVLQVIVNVLDLGLDLQQAVDAPRIHHQLPDVL 446
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611  537 EYEPNFSqkqdlaalprlvsnswpqvillpqppkllalQEVQRGLQDRGQNQTQRPFFLNVVQAVSQ--EGACVYAVSDL 614
Cdd:pfam01019 447 EVEPGFP-------------------------------EEVLAELEARGHKVKVVEDSSSVGAIQIVrrTGGVLYAASDP 495

                  ....
gi 768024611  615 RKSG 618
Cdd:pfam01019 496 RRDG 499
Ggt COG0405
Gamma-glutamyltranspeptidase [Amino acid transport and metabolism];
54-551 6.30e-100

Gamma-glutamyltranspeptidase [Amino acid transport and metabolism];


Pssm-ID: 440174  Cd Length: 507  Bit Score: 313.91  E-value: 6.30e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611  54 SDIGRAILQQQGSPVDATIAALVCTSVVNPQSMGLGGGVIFTIYNVTTGKVEVINARETVPASHAPSLLDQCAQALPlGT 133
Cdd:COG0405   10 SQAGLEILRAGGNAVDAAVAAAAALAVVEPHSSGIGGGGFALIYDAKDGKVTALDGRGTAPAAATPDMYLDAGDEIP-VR 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611 134 GAQWIGVPGELRGYAEAHRRHGRLPWAQLFQPTIALLRGGHVVAPVLSRFLHNSilRPSLQAS-TLRQLFFNGTEPLRPQ 212
Cdd:COG0405   89 GPLAVGVPGTVAGWEAAHERYGTLPLAELLAPAIRLAEDGFPVSPRLAALLAAA--AERLARDpGAAAIFLPDGRPPKAG 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611 213 DPLPWPALATTLETVATEGVEVFYTGRLGQMLVEDIAKEGSQLTLQDLAKFQPEVVDALEVPLGDYTLYSPPPPAGGAIL 292
Cdd:COG0405  167 DILRQPDLAATLRRIAEEGADAFYRGEIAEAIVAAVQAAGGLLTLEDLAAYRAEWREPLSGTYRGYTVYSMPPPSQGIAL 246
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611 293 SFILNVLRGFNFSTESMARPEGrvnvYHHLVETLK--FAKGQRWrLGDPRSHPklqNASRDLLGETLAQLIRQQIDGRGD 370
Cdd:COG0405  247 LQILNILEGFDLAALGPDSAEY----VHLLAEAMKlaFADRDRY-LGDPDFVD---VPVEGLLSPAYAAERAALIDPDRA 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611 371 HQLSHYSLAEAWGHGtGTSHVSVLGEDGSAVAATSTINTPFGAMVYSPRTGIILNNelldlcercpRGSGTTPSPdavcs 450
Cdd:COG0405  319 TPSPRPGDPTGPESG-DTTHLSVVDRDGNAVSLTQSIYGGFGSGVVVPGTGFLLNN----------RGDDFSLDP----- 382
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611 451 avsgdrvgGAPGRcwpPVPGERSPSSMVPSILInKAQGSKLVIGGAGGELIISAVAQAIMSKLWLGFDLRAAIAAP-ILH 529
Cdd:COG0405  383 --------GHPNA---LAPGKRPRSTMSPTIVL-KDGKPVLVFGSPGGSRIPQTVLQVLLNVLDFGMNPQEAVDAPrWHH 450
                        490       500
                 ....*....|....*....|....
gi 768024611 530 VNSKGCVEYEPNFSQ--KQDLAAL 551
Cdd:COG0405  451 QGLPDTLELEPRFPPavIAALRAR 474
g_glut_trans TIGR00066
gamma-glutamyltranspeptidase; Also called gamma-glutamyltranspeptidase (ggt). Some members of ...
54-615 5.30e-83

gamma-glutamyltranspeptidase; Also called gamma-glutamyltranspeptidase (ggt). Some members of this family have antibiotic synthesis or resistance activities. In the case of a cephalosporin acylase from Pseudomonas sp., the enzyme was shown to retain some gamma-glutamyltranspeptidase activity. Other, more distantly related proteins have ggt-related activities and score below the trusted cutoff. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs]


Pssm-ID: 129176  Cd Length: 516  Bit Score: 270.10  E-value: 5.30e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611   54 SDIGRAILQQQGSPVDATIAALVCTSVVNPQSMGLGGGVIFTIYNVTTGKVEVINARETVPA-SHAPSLLDQCAQALPLG 132
Cdd:TIGR00066  11 SEIGEDILKEGGNAFDAAVAVGLALAVVEPFMTGLGGGGFMLISGKKTKDTTAIDFRERAPAkATRDMFLDKSGNPLPGK 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611  133 --TGAQWIGVPGELRGYAEAHRRHGRLPWAQLFQPTIALLRGGHVVAPVLSRFLHNSILRPSLQASTLRQLFFNGTEPLR 210
Cdd:TIGR00066  91 slTGGLAIGVPGTVAGLEAALKKYGTLPLKDLIEPAIKLARNGFPINEALADTLELYEEVLLTTKEDSKDIFNPTGKPLK 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611  211 PQDPLPWPALATTLETVATEGVEVFYTGRLGQMLVEDIAKEGSQLTLQDLAKFQPEVvdalEVPL-GDYTLYS----PPP 285
Cdd:TIGR00066 171 EGDTLVQKDLAKSLELIAENGPDAFYKGDIAESIIDTLQKNGGIMTKKDLAAYDVEI----RKPLsGDYRGYQvyttPPP 246
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611  286 PAGGAILSFILNVLRGFNFStesmARPEGRVNVYHHLVETLKFAKGQRWR-LGDPRSHPKlqnASRDLLGETLAQLIRQQ 364
Cdd:TIGR00066 247 SSGGIHLLQALNILENFDLS----QYGDGSAETYQLLAEAMKLSYADRSRyLGDPEFVDV---PLEELLDKRYAKELAQS 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611  365 ID-GRGDHQLSHYSLAEAWGHGTGTSHVSVLGEDGSAVAATSTINTPFGAMVYSPRTGIILNNELLDLCERcprgsgttp 443
Cdd:TIGR00066 320 IKiNKVDPKSTIYPGAYQPNEGSQTTHFSVVDRDGNAVSLTTTINLEFGSGVHAPDTGILLNNEMDDFSLK--------- 390
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611  444 spdavcsavsgdrvggaPGRCWPPVPGERSPSSMVPSILINKAQgSKLVIGGAGGELIISAVAQAIMSKLWLGFDLRAAI 523
Cdd:TIGR00066 391 -----------------PGGANAVEPNKRPLSSMAPTIVLKDGK-PDLVVGSPGGSRIITTVLQTIVRHIDYGMPLAEAV 452
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611  524 AAPILHVNS-KGCVEYEPNFsqkqdlaalprlvsnswpqvillpqPPKLLALqevqrgLQDRGQNQTQRP-FFLNVVQAV 601
Cdd:TIGR00066 453 SEPRIHHQWlPDELRLEKGF-------------------------PDDVLQL------LKDMGHKVTLKEvFPMGVVQAI 501
                         570
                  ....*....|....*
gi 768024611  602 S-QEGACVYAVSDLR 615
Cdd:TIGR00066 502 RvDPEGWLYGVSDPR 516
PLN02180 PLN02180
gamma-glutamyl transpeptidase 4
49-543 3.11e-73

gamma-glutamyl transpeptidase 4


Pssm-ID: 177836  Cd Length: 639  Bit Score: 247.28  E-value: 3.11e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611  49 DSKVCSDIGRAILQQQGSPVDATIAALVCTSVVNPQSMGLGGGVIFTIYNVTTGKVEVINARETVPASHAPSLLDQCAQA 128
Cdd:PLN02180  88 DDARCSEIGASVLRRGGHAVDAAVAITLCIGVVNPMSSGIGGGSFLIVSSQKDSKAEAFDMRETAPLAASKDMYKNDASA 167
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611 129 LPLGtgAQWIGVPGELRGYAEAHRRHGRLPWAQLFQPTIALLRGGHVVAPVLSRFLHNSILRpSLQASTLRQLFFNGTEP 208
Cdd:PLN02180 168 KSLG--ALSMGVPGEIAGLYEAWKRYGRLPWKPLFEPAIELARDGFVVHPYLGKAISSHAAM-ILKDPGLRSVFSRNGQV 244
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611 209 LRPQDPLPWPALATTLETVATEGVEVFYTGRLGQMLVEDIAKEGSQLTLQDLAKFQPEVVDALEVPLGDYTLYSPPPPAG 288
Cdd:PLN02180 245 LKPGETCYNPELAQSLETISEQGPGAFYNGTIGEKLVKDVKKAGGIITMDDLRSYEVLVTDAMSVDVMGYTIHGMPPPSG 324
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611 289 GAI-LSFILNVLRGF-NFSTESmarpeGRVNVYHHLVETLKFAKGQRWRLGDPrSHPKLQNASRDLLGETLAQLIRQQID 366
Cdd:PLN02180 325 GTLgFSMVIDILDSYsNLYTAS-----GRELGLHRLIEAMKHMFAARMDLGDP-EFVNITNAMNQMLSKAHAEEIQKRIF 398
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611 367 GRGDHQLSHYSLAEAWGHGTGTSHVSVLGEDGSAVAATSTINTPFGAMVYSPRTGIILNNELLDLcercprgsgTTPspd 446
Cdd:PLN02180 399 DNTTFPPEYYLNRWSQLRDQGTSHFCIVDADRNSVSMTSTVNYGFGAGVLSPSTGIVLNNEMDDF---------STP--- 466
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611 447 avcSAVSGDRVGGAPGRCWPpvPGERSPSSMVPsILINKAQGSKLVIGGAGGELIISAVAQAIMSKLWLGFDLRAAI-AA 525
Cdd:PLN02180 467 ---AEITPDMLPPAPTNFIE--PNKRPLSSMTP-LVITKDGEFVAALGGAGGMHIIPAVLQVFLNCFVLNMKPKEAVeSA 540
                        490
                 ....*....|....*...
gi 768024611 526 PILHVNSKGCVEYEpNFS 543
Cdd:PLN02180 541 RIYHRLIPNVVSYE-NFT 557
 
Name Accession Description Interval E-value
G_glu_transpept pfam01019
Gamma-glutamyltranspeptidase;
58-618 0e+00

Gamma-glutamyltranspeptidase;


Pssm-ID: 425991  Cd Length: 499  Bit Score: 563.76  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611   58 RAILQQQGSPVDATIAALVCTSVVNPQSMGLGGGVIFTIYNVTTGKVEVINARETVPASHAPSLLDQCAQALPLGTGAQW 137
Cdd:pfam01019   1 LDILRKGGNAVDAAVAAALCLGVVEPHSSGIGGGGFMLIYDAKTGKVLVIDARETAPAAATKDMFDGKGDSKLSLTGGLA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611  138 IGVPGELRGYAEAHRRHGRLPWAQLFQPTIALLRGGHVVAPVLSRFLHNSILRPsLQASTLRQLFFNGTEPLRPQDPLPW 217
Cdd:pfam01019  81 VGVPGEVAGLAEAHKRYGRLPWADLLEPAIKLARDGFPVSPALARALARAEERL-RADPGLRKIFLPTGRVLKAGELLKQ 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611  218 PALATTLETVATEGVEVFYTGRLGQMLVEDIAKEGSQLTLQDLAKFQPEVVDALEVPLGDYTLYSPPPPAGGAILSFILN 297
Cdd:pfam01019 160 PALAKTLELIAEEGPDAFYRGELAQQLVADLQANGGIITAEDLANYRVKIREPLSADYGGYTVYSPPPSSGGIALLQILN 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611  298 VLRGFNFSTESmarpeGRVNVYHHLVETLKFAKGQRWR-LGDPRSHPKLQnasRDLLGETLAQLIRQQIDGRGDHQLSHy 376
Cdd:pfam01019 240 ILEGFDLSSLL-----NSAEYLHLLIEAMKLAYADRTRyLGDPDFVPVPV---ENLLSPEYAKERAKLINPNAAFPSSY- 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611  377 slaeaWGHGTGTSHVSVLGEDGSAVAATSTINTPFGAMVYSPRTGIILNNELLDLCERCPRGSGTTPSPDAvcsavsgdr 456
Cdd:pfam01019 311 -----APEDGGTTHFSVVDRDGNAVSFTSTINLGFGSGVVVPGTGILLNNEMDDFSTPPGNAFGLDPSPAN--------- 376
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611  457 vggapgrcwPPVPGERSPSSMVPSILINKaQGSKLVIGGAGGELIISAVAQAIMSKLWLGFDLRAAIAAPILHVNSKGCV 536
Cdd:pfam01019 377 ---------AIAPGKRPLSSMAPTIVLDD-GKPVLVVGAPGGSRIISAVLQVIVNVLDLGLDLQQAVDAPRIHHQLPDVL 446
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611  537 EYEPNFSqkqdlaalprlvsnswpqvillpqppkllalQEVQRGLQDRGQNQTQRPFFLNVVQAVSQ--EGACVYAVSDL 614
Cdd:pfam01019 447 EVEPGFP-------------------------------EEVLAELEARGHKVKVVEDSSSVGAIQIVrrTGGVLYAASDP 495

                  ....
gi 768024611  615 RKSG 618
Cdd:pfam01019 496 RRDG 499
Ggt COG0405
Gamma-glutamyltranspeptidase [Amino acid transport and metabolism];
54-551 6.30e-100

Gamma-glutamyltranspeptidase [Amino acid transport and metabolism];


Pssm-ID: 440174  Cd Length: 507  Bit Score: 313.91  E-value: 6.30e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611  54 SDIGRAILQQQGSPVDATIAALVCTSVVNPQSMGLGGGVIFTIYNVTTGKVEVINARETVPASHAPSLLDQCAQALPlGT 133
Cdd:COG0405   10 SQAGLEILRAGGNAVDAAVAAAAALAVVEPHSSGIGGGGFALIYDAKDGKVTALDGRGTAPAAATPDMYLDAGDEIP-VR 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611 134 GAQWIGVPGELRGYAEAHRRHGRLPWAQLFQPTIALLRGGHVVAPVLSRFLHNSilRPSLQAS-TLRQLFFNGTEPLRPQ 212
Cdd:COG0405   89 GPLAVGVPGTVAGWEAAHERYGTLPLAELLAPAIRLAEDGFPVSPRLAALLAAA--AERLARDpGAAAIFLPDGRPPKAG 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611 213 DPLPWPALATTLETVATEGVEVFYTGRLGQMLVEDIAKEGSQLTLQDLAKFQPEVVDALEVPLGDYTLYSPPPPAGGAIL 292
Cdd:COG0405  167 DILRQPDLAATLRRIAEEGADAFYRGEIAEAIVAAVQAAGGLLTLEDLAAYRAEWREPLSGTYRGYTVYSMPPPSQGIAL 246
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611 293 SFILNVLRGFNFSTESMARPEGrvnvYHHLVETLK--FAKGQRWrLGDPRSHPklqNASRDLLGETLAQLIRQQIDGRGD 370
Cdd:COG0405  247 LQILNILEGFDLAALGPDSAEY----VHLLAEAMKlaFADRDRY-LGDPDFVD---VPVEGLLSPAYAAERAALIDPDRA 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611 371 HQLSHYSLAEAWGHGtGTSHVSVLGEDGSAVAATSTINTPFGAMVYSPRTGIILNNelldlcercpRGSGTTPSPdavcs 450
Cdd:COG0405  319 TPSPRPGDPTGPESG-DTTHLSVVDRDGNAVSLTQSIYGGFGSGVVVPGTGFLLNN----------RGDDFSLDP----- 382
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611 451 avsgdrvgGAPGRcwpPVPGERSPSSMVPSILInKAQGSKLVIGGAGGELIISAVAQAIMSKLWLGFDLRAAIAAP-ILH 529
Cdd:COG0405  383 --------GHPNA---LAPGKRPRSTMSPTIVL-KDGKPVLVFGSPGGSRIPQTVLQVLLNVLDFGMNPQEAVDAPrWHH 450
                        490       500
                 ....*....|....*....|....
gi 768024611 530 VNSKGCVEYEPNFSQ--KQDLAAL 551
Cdd:COG0405  451 QGLPDTLELEPRFPPavIAALRAR 474
g_glut_trans TIGR00066
gamma-glutamyltranspeptidase; Also called gamma-glutamyltranspeptidase (ggt). Some members of ...
54-615 5.30e-83

gamma-glutamyltranspeptidase; Also called gamma-glutamyltranspeptidase (ggt). Some members of this family have antibiotic synthesis or resistance activities. In the case of a cephalosporin acylase from Pseudomonas sp., the enzyme was shown to retain some gamma-glutamyltranspeptidase activity. Other, more distantly related proteins have ggt-related activities and score below the trusted cutoff. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs]


Pssm-ID: 129176  Cd Length: 516  Bit Score: 270.10  E-value: 5.30e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611   54 SDIGRAILQQQGSPVDATIAALVCTSVVNPQSMGLGGGVIFTIYNVTTGKVEVINARETVPA-SHAPSLLDQCAQALPLG 132
Cdd:TIGR00066  11 SEIGEDILKEGGNAFDAAVAVGLALAVVEPFMTGLGGGGFMLISGKKTKDTTAIDFRERAPAkATRDMFLDKSGNPLPGK 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611  133 --TGAQWIGVPGELRGYAEAHRRHGRLPWAQLFQPTIALLRGGHVVAPVLSRFLHNSILRPSLQASTLRQLFFNGTEPLR 210
Cdd:TIGR00066  91 slTGGLAIGVPGTVAGLEAALKKYGTLPLKDLIEPAIKLARNGFPINEALADTLELYEEVLLTTKEDSKDIFNPTGKPLK 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611  211 PQDPLPWPALATTLETVATEGVEVFYTGRLGQMLVEDIAKEGSQLTLQDLAKFQPEVvdalEVPL-GDYTLYS----PPP 285
Cdd:TIGR00066 171 EGDTLVQKDLAKSLELIAENGPDAFYKGDIAESIIDTLQKNGGIMTKKDLAAYDVEI----RKPLsGDYRGYQvyttPPP 246
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611  286 PAGGAILSFILNVLRGFNFStesmARPEGRVNVYHHLVETLKFAKGQRWR-LGDPRSHPKlqnASRDLLGETLAQLIRQQ 364
Cdd:TIGR00066 247 SSGGIHLLQALNILENFDLS----QYGDGSAETYQLLAEAMKLSYADRSRyLGDPEFVDV---PLEELLDKRYAKELAQS 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611  365 ID-GRGDHQLSHYSLAEAWGHGTGTSHVSVLGEDGSAVAATSTINTPFGAMVYSPRTGIILNNELLDLCERcprgsgttp 443
Cdd:TIGR00066 320 IKiNKVDPKSTIYPGAYQPNEGSQTTHFSVVDRDGNAVSLTTTINLEFGSGVHAPDTGILLNNEMDDFSLK--------- 390
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611  444 spdavcsavsgdrvggaPGRCWPPVPGERSPSSMVPSILINKAQgSKLVIGGAGGELIISAVAQAIMSKLWLGFDLRAAI 523
Cdd:TIGR00066 391 -----------------PGGANAVEPNKRPLSSMAPTIVLKDGK-PDLVVGSPGGSRIITTVLQTIVRHIDYGMPLAEAV 452
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611  524 AAPILHVNS-KGCVEYEPNFsqkqdlaalprlvsnswpqvillpqPPKLLALqevqrgLQDRGQNQTQRP-FFLNVVQAV 601
Cdd:TIGR00066 453 SEPRIHHQWlPDELRLEKGF-------------------------PDDVLQL------LKDMGHKVTLKEvFPMGVVQAI 501
                         570
                  ....*....|....*
gi 768024611  602 S-QEGACVYAVSDLR 615
Cdd:TIGR00066 502 RvDPEGWLYGVSDPR 516
PLN02180 PLN02180
gamma-glutamyl transpeptidase 4
49-543 3.11e-73

gamma-glutamyl transpeptidase 4


Pssm-ID: 177836  Cd Length: 639  Bit Score: 247.28  E-value: 3.11e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611  49 DSKVCSDIGRAILQQQGSPVDATIAALVCTSVVNPQSMGLGGGVIFTIYNVTTGKVEVINARETVPASHAPSLLDQCAQA 128
Cdd:PLN02180  88 DDARCSEIGASVLRRGGHAVDAAVAITLCIGVVNPMSSGIGGGSFLIVSSQKDSKAEAFDMRETAPLAASKDMYKNDASA 167
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611 129 LPLGtgAQWIGVPGELRGYAEAHRRHGRLPWAQLFQPTIALLRGGHVVAPVLSRFLHNSILRpSLQASTLRQLFFNGTEP 208
Cdd:PLN02180 168 KSLG--ALSMGVPGEIAGLYEAWKRYGRLPWKPLFEPAIELARDGFVVHPYLGKAISSHAAM-ILKDPGLRSVFSRNGQV 244
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611 209 LRPQDPLPWPALATTLETVATEGVEVFYTGRLGQMLVEDIAKEGSQLTLQDLAKFQPEVVDALEVPLGDYTLYSPPPPAG 288
Cdd:PLN02180 245 LKPGETCYNPELAQSLETISEQGPGAFYNGTIGEKLVKDVKKAGGIITMDDLRSYEVLVTDAMSVDVMGYTIHGMPPPSG 324
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611 289 GAI-LSFILNVLRGF-NFSTESmarpeGRVNVYHHLVETLKFAKGQRWRLGDPrSHPKLQNASRDLLGETLAQLIRQQID 366
Cdd:PLN02180 325 GTLgFSMVIDILDSYsNLYTAS-----GRELGLHRLIEAMKHMFAARMDLGDP-EFVNITNAMNQMLSKAHAEEIQKRIF 398
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611 367 GRGDHQLSHYSLAEAWGHGTGTSHVSVLGEDGSAVAATSTINTPFGAMVYSPRTGIILNNELLDLcercprgsgTTPspd 446
Cdd:PLN02180 399 DNTTFPPEYYLNRWSQLRDQGTSHFCIVDADRNSVSMTSTVNYGFGAGVLSPSTGIVLNNEMDDF---------STP--- 466
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611 447 avcSAVSGDRVGGAPGRCWPpvPGERSPSSMVPsILINKAQGSKLVIGGAGGELIISAVAQAIMSKLWLGFDLRAAI-AA 525
Cdd:PLN02180 467 ---AEITPDMLPPAPTNFIE--PNKRPLSSMTP-LVITKDGEFVAALGGAGGMHIIPAVLQVFLNCFVLNMKPKEAVeSA 540
                        490
                 ....*....|....*...
gi 768024611 526 PILHVNSKGCVEYEpNFS 543
Cdd:PLN02180 541 RIYHRLIPNVVSYE-NFT 557
PLN02198 PLN02198
glutathione gamma-glutamylcysteinyltransferase
49-539 1.68e-71

glutathione gamma-glutamylcysteinyltransferase


Pssm-ID: 177849  Cd Length: 573  Bit Score: 241.13  E-value: 1.68e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611  49 DSKVCSDIGRAILQQQGSPVDATIAALVCTSVVNPQSMGLGGGViFTIYNVTTGKVEVINARETVPASHAPSLLDqcAQA 128
Cdd:PLN02198  39 DDGRCSVIGMNVLREGGNAIDASVAAALCLGVVSPASSGIGGGA-FTLIKLANGEEIAYDSRETAPLSATENMYG--GNV 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611 129 LPLGTGAQWIGVPGELRGYAEAHRRHGRLPWAQLFQPTIALLRGGHVVAPVLsRFLHNSILRPSLQASTLRQLFFNGTEP 208
Cdd:PLN02198 116 ELKKKGALSVGVPGEVAGLFTAWKQHGKLPWKRLVRPAEKLAAEGFKISKYL-YMQMNATRSDILADKGLSDLFVSNGEL 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611 209 LRPQDPLPWPALATTLETVATEGVEVFYTGRLGQMLVEDIAKEGSQLTLQDLAKFQPEVVDALEVP-LGDYTLYSPPPPA 287
Cdd:PLN02198 195 KKPGTICHNPKLALTLRLIGEYGPKAFYNGTVGVNLVRDIQKSGGIITLKDLQSYRVKVKEPLSADiLGYRVLGMPPPSS 274
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611 288 GGAILSFILNVLRGFNFStESMARPEGrvnvYHHLVETLKFAKGQRWRLGDPrSHPKLQNASRDLLGETLAQLIRQQIDG 367
Cdd:PLN02198 275 GGAAMMLILNILAQYGIP-SGVSGPLG----VHRLIEALKHAFAVRMNLGDP-DFVDVTKVVSDMLSPKFAQDLKSKIND 348
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611 368 RGDHQLSHYslAEAWG--HGTGTSHVSVLGEDGSAVAATSTINTPFGAMVYSPRTGIILNNELLDLCERCPRGSGTTPSP 445
Cdd:PLN02198 349 NKTFDPKHY--GGRWNqiDDHGTSHLSIIDSERNAVSMTSTINGYFGALMLSPSTGIVLNNEMDDFSIPMKSGGNLDVPP 426
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611 446 DAVCSAVSgdrvggapgrcwppvPGERSPSSMVPSILInKAQGSKLVIGGAGGELIISAVAQAIMSKLWLGFDLRAAIAA 525
Cdd:PLN02198 427 PAPANFIR---------------PGKRPLSSMTPTIVL-KDGKVKAAVGASGGANIIAGTTEVYLNHFFLKMDPLSSVLA 490
                        490
                 ....*....|....*
gi 768024611 526 P-ILHVNSKGCVEYE 539
Cdd:PLN02198 491 PrIYHQLIPNRASYE 505
ggt PRK09615
gamma-glutamyltranspeptidase; Reviewed
56-529 1.53e-50

gamma-glutamyltranspeptidase; Reviewed


Pssm-ID: 181992  Cd Length: 581  Bit Score: 184.34  E-value: 1.53e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611  56 IGRAILQQQGSPVDATIAALVCTSVVNPQSMGLGGGViFTIYNVTTGKVEVINARETVPASHAPSL-LDqcAQALPLG-- 132
Cdd:PRK09615  62 VGVDILKQGGNAVDAAVAVGYALAVTHPQAGNLGGGG-FMLLRTKNGNTTAIDFREMAPAKATRDMfLD--DQGNPDSkk 138
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611 133 --TGAQWIGVPGELRGYAEAHRRHGRLPWAQLFQPTIALLRGGHVVAPVLSRFLHNSILRPSLQASTLRQLFFNGTEPLR 210
Cdd:PRK09615 139 slTSHLASGTPGTVAGFSLALDKYGTMPLNKVVQPAFKLARDGFIVNDALADDLKTYGSEVLPNHENSKAIFWKEGEPLK 218
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611 211 PQDPLPWPALATTLETVATEGVEVFYTGRLGQMLVEDIAKEGSQLTLQDLAKFQpevvdALE-VPLG----DYTLYSPPP 285
Cdd:PRK09615 219 KGDKLVQANLAKSLEMIAENGPDAFYKGTIADQIAQEMQKNGGLITKEDLAAYK-----AVErTPISgdyrGYQVYSMPP 293
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611 286 PAGGAI-LSFILNVLRGFNFSTESMarpeGRVNVYHHLVETLKFAKGQRWR-LGDPRShpkLQNASRDLLGETLAQLIRQ 363
Cdd:PRK09615 294 PSSGGIhIVQILNILENFDMKKYGF----GSADAMQIMAEAEKYAYADRSEyLGDPDF---VKVPWQALTNKAYAKSIAD 366
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611 364 QID---GRGDHQLSHYSLAEAwgHGTGTSHVSVLGEDGSAVAATSTINTPFGAMVYSPRTGIILNNELLDLCERcprgsg 440
Cdd:PRK09615 367 QIDinkAKPSSEIRPGKLAPY--ESNQTTHFSVVDKDGNAVAVTYTLNTTFGTGIVAGNSGILLNNQMDDFSAK------ 438
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024611 441 ttPSPDAVCSAVSGDrvGGAPGrcwppvPGERSPSSMVPSILInKAQGSKLVIGGAGGELIISAVAQAIMSKLWLGFDLR 520
Cdd:PRK09615 439 --PGVPNVYGLVGGD--ANAVG------PNKRPLSSMSPTIVV-KDGKTWLVTGSPGGSRIITTVLQMVVNSIDYGMNVA 507

                 ....*....
gi 768024611 521 AAIAAPILH 529
Cdd:PRK09615 508 EATNAPRFH 516
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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