KIX-binding domain of forkhead box O, CR2; FOXO_KIX_bd is the first part of the region of transcription factor forkhead box O family proteins that binds to the CREB-binding proteins via the KIX domain. Coactivator CBP/p300 is recruited by FOXO3 via the binding of this domain as well as the simultaneous binding of the more C-terminal TAD domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977483  242 KYTYGQSSMSPLPQMPIQTLQDNK-SSYGGMSQYNcAPGLLKELLTSDSPPHNDIMTPVDPGVAQPNSRVLGQNVmmGPN 320
Cdd:pfam16675   1 KSIYGQPSMNSLRQMPMQTIQENKqSSFGSMSQYG-PAGLLQELLTSDSYPHSDILTQVDPLMSQASGRVLSQNH--RQN 77

                  ...
gi 767977483  321 SVM 323
Cdd:pfam16675  78 SVM 80

Transactivation domain of FOXO protein family; TAD is a promiscuous binding domain that mediates the association of the transcription factor FOXO with the coactivator CBP/p300. Both this domain and the FOXO-KIX_bd family pfam16675 bind simultaneously the KIX domain of CBP/p300. Coactivator CBP/p300 is recruited by FOXO3 though binding to these two regions. The promiscuity of the TAD is further evidenced by that the finding that they also bind the TAZ1 and TAZ2 domains of CBP/p300.

                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 767977483  416 KLPSDLD-GMFIERLDCDMESIIRNDLMDGDTLDFNFD 452
Cdd:pfam16676   1 RLPSDLDlDMFQGSLECDVDSIIRNDLMDGDGLDFNFD 38

KIX-binding domain of forkhead box O, CR2; FOXO_KIX_bd is the first part of the region of transcription factor forkhead box O family proteins that binds to the CREB-binding proteins via the KIX domain. Coactivator CBP/p300 is recruited by FOXO3 via the binding of this domain as well as the simultaneous binding of the more C-terminal TAD domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977483  242 KYTYGQSSMSPLPQMPIQTLQDNK-SSYGGMSQYNcAPGLLKELLTSDSPPHNDIMTPVDPGVAQPNSRVLGQNVmmGPN 320
Cdd:pfam16675   1 KSIYGQPSMNSLRQMPMQTIQENKqSSFGSMSQYG-PAGLLQELLTSDSYPHSDILTQVDPLMSQASGRVLSQNH--RQN 77

                  ...
gi 767977483  321 SVM 323
Cdd:pfam16675  78 SVM 80

Transactivation domain of FOXO protein family; TAD is a promiscuous binding domain that mediates the association of the transcription factor FOXO with the coactivator CBP/p300. Both this domain and the FOXO-KIX_bd family pfam16675 bind simultaneously the KIX domain of CBP/p300. Coactivator CBP/p300 is recruited by FOXO3 though binding to these two regions. The promiscuity of the TAD is further evidenced by that the finding that they also bind the TAZ1 and TAZ2 domains of CBP/p300.

                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 767977483  416 KLPSDLD-GMFIERLDCDMESIIRNDLMDGDTLDFNFD 452
Cdd:pfam16676   1 RLPSDLDlDMFQGSLECDVDSIIRNDLMDGDGLDFNFD 38

Forkhead domain;

                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 767977483   27 WcQNSIRHNLSLHSKFIRV--QNEGTGKSSWWMLNPE 61
Cdd:pfam00250  45 W-QNSIRHNLSLNKCFVKVprPKDEPGKGSYWTIDPE 80

KIX-binding domain of forkhead box O, CR2; FOXO_KIX_bd is the first part of the region of transcription factor forkhead box O family proteins that binds to the CREB-binding proteins via the KIX domain. Coactivator CBP/p300 is recruited by FOXO3 via the binding of this domain as well as the simultaneous binding of the more C-terminal TAD domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977483  242 KYTYGQSSMSPLPQMPIQTLQDNK-SSYGGMSQYNcAPGLLKELLTSDSPPHNDIMTPVDPGVAQPNSRVLGQNVmmGPN 320
Cdd:pfam16675   1 KSIYGQPSMNSLRQMPMQTIQENKqSSFGSMSQYG-PAGLLQELLTSDSYPHSDILTQVDPLMSQASGRVLSQNH--RQN 77

                  ...
gi 767977483  321 SVM 323
Cdd:pfam16675  78 SVM 80

Forkhead (FH) domain found in Forkhead box protein O1 (FOXO1); FOXO1, also called Forkhead box protein O1A or Forkhead in rhabdomyosarcoma (FKHR), is a transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. It binds to the insulin response element (IRE) with the consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with the consensus sequence 5'-TT[G/A]TTTAC-3'. The FH domain is a winged helix DNA-binding domain.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 767977483  29 QNSIRHNLSLHSKFIRVQNEGTGKSSWWMLNPEGGKSGKS 68
Cdd:cd20060   60 KNSIRHNLSLHSKFIRVQNEGTGKSSWWMLNPEGGKSGKS 99

Forkhead (FH) domain found in Forkhead box protein O3 (FOXO3); FOXO3, also called AF6q21 protein or Forkhead in rhabdomyosarcoma-like 1 (FKHRL1), is a transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. It recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. The FH domain is a winged helix DNA-binding domain. All FOXOs bind to the consensus sequence 5'-GTAAACAA-3', known as the DAF-16 family member-binding element, which includes the core sequence 5'-(A/C)AA(C/T)A-3' recognized by all FOX family members.

                         10        20        30
                 ....*....|....*....|....*....|...
gi 767977483  29 QNSIRHNLSLHSKFIRVQNEGTGKSSWWMLNPE 61
Cdd:cd20061   51 KNSIRHNLSLHSRFIRVQNEGTGKSSWWMINPD 83

Forkhead (FH) domain found in the Forkhead box protein O (FOXO) subfamily; The FOXO subfamily includes several winged helix transcription factors: FOXO1, FOXO3, FOXO4 and FOXO6. FOXO transcription factors are involved in the regulation of longevity phenomenon via insulin and insulin-like growth factor signaling. All FOXOs bind to the consensus sequence 5'-GTAAACAA-3', known as the DAF-16 family member-binding element, which includes the core sequence 5'-(A/C)AA(C/T)A-3' recognized by all FOX family members. FOXO1, also called Forkhead box protein O1A or Forkhead in rhabdomyosarcoma (FKHR), is a transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. FOXO3, also called AF6q21 protein or Forkhead in rhabdomyosarcoma-like 1 (FKHRL1), is a transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. It recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. FOXO4, also called Fork head domain transcription factor AFX1, is a transcription factor involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. FOXO6 acts as a transcriptional activator that may play an important role on tumor invasion, metastasis, and prognosis. The FH domain is a winged helix DNA-binding domain.

                         10        20        30
                 ....*....|....*....|....*....|.
gi 767977483  29 QNSIRHNLSLHSKFIRVQNEGTGKSSWWMLN 59
Cdd:cd20032   50 KNSIRHNLSLHSRFVRVQNEGTGKSSWWTLN 80

Forkhead (FH) domain found in Forkhead box (FOX) family of transcription factors and similar proteins; The FOX family comprises diverse tissue- and cell type-specific transcription factors with an evolutionary conserved "Forkhead (FH)" or "winged helix" DNA-binding domain. FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. The structure of the FH domain contains 2 flexible loops or "wings" in the C-terminal region, hence the term winged helix. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'. They participate in a variety of cellular processes, such as cell cycle progression, proliferation, differentiation, migration, metabolism, and DNA damage response. Their expression can be regulated by multiple factors, and they can act as co-activators and/or transcriptional repressors. Fifty FOX-encoding genes in humans have been categorized into 19 subfamilies based on protein sequence homology (FOXA to FOXS).

                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 767977483  23 AQNCWcQNSIRHNLSLHSKFIRVQNEGT--GKSSWWM 57
Cdd:cd00059   40 ATKGW-KNSIRHNLSLNKCFVKVPREPSdpGKGSYWT 75

Forkhead (FH) domain found in Forkhead box protein Q2 (FOXQ2) and similar proteins; FOXQ2 is the neurogenic ectoderm specification transcription factor that controls aboral development in cnidarians and anterior identity in bilaterians. It plays essential roles in epidermal development and central brain patterning. The foxQ2 gene is absent in placental mammals. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 767977483  27 WcQNSIRHNLSLHSKFIRVQNEGTGKSSWWMLNPEGGKS---GKSPRRRA 73
Cdd:cd20035   45 W-KNSVRHNLSLNECFVKAGRAENGKGNYWTIHPACLEDfekGDFRRRRA 93

Forkhead (FH) domain found in Forkhead box protein J1 (FOXJ1) and similar proteins; FOXJ1, also called Forkhead-related protein FKHL13 or hepatocyte nuclear factor 3 Forkhead homolog 4 (HFH-4), acts as a transcription factor specifically required for the formation of motile cilia. It acts by activating transcription of genes that mediate assembly of motile cilia, such as CFAP157. FOXJ1 binds the DNA consensus sequences 5'-HWDTGTTTGTTTA-3' or 5'-KTTTGTTGTTKTW-3' (where H is not G, W is A or T, D is not C, and K is G or T). It activates the transcription of a variety of ciliary proteins in the developing brain and lung. The FH domain is a winged helix DNA-binding domain.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 767977483  22 LAQNCWcQNSIRHNLSLHSKFIRV--QNEGTGKSSWWMLNP 60
Cdd:cd20023   40 VADPTW-QNSIRHNLSLNKCFIKVprSKDEPGKGGFWRIDP 79

Forkhead (FH) domain found in the Forkhead box protein M (FOXM) subfamily; The FOXM subfamily includes a winged helix transcription factor, FOXM1, which is also called Forkhead-related protein FKHL16, Hepatocyte nuclear factor 3 Forkhead homolog 11 (HFH-11), HNF-3/fork-head homolog 11, M-phase phosphoprotein 2, MPM-2 reactive phosphoprotein 2, transcription factor Trident, or Winged-helix factor from INS-1 cells. FOXM1 acts as a transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. It plays a role in the control of cell proliferation. It is also involved in DNA break repair, participating in the DNA damage checkpoint response. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30
                 ....*....|....*....|....*....|..
gi 767977483  29 QNSIRHNLSLHSKFIRvQNEGTGKSSWWMLNP 60
Cdd:cd20029   47 KNSIRHNLSLHDIFVR-ETSANGKGSFWTLRP 77

Forkhead (FH) domain found in the Forkhead box protein G (FOXG) subfamily; The FOXG subfamily includes a winged helix transcription factor FOXG1, which is also called brain factor 1 (BF-1), brain factor 2 (BF-2), Forkhead box protein G1A, Forkhead box protein G1B, Forkhead box protein G1C, Forkhead-related protein FKHL1, Forkhead-related protein FKHL2, or Forkhead-related protein FKHL3. FOXG1 acts as a transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon. It is repetitively used in the sequential events of telencephalic development to control multi-steps of brain circuit formation ranging from cell cycle control to neuronal differentiation in a clade- and species-specific manner. Individuals with mutations in FOXG1 harbor "FOXG1-related encephalopathy", characterized by two clinical phenotypes/syndromes including microcephaly, developmental delay, severe cognitive disabilities, early-onset dyskinesia and hyperkinetic movements, stereotypies, epilepsy, and cerebral malformation for those with deletions or intragenic mutations of FOXG1. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30
                 ....*....|....*....|....*....|....
gi 767977483  29 QNSIRHNLSLHSKFIRVQN--EGTGKSSWWMLNP 60
Cdd:cd20021   46 QNSIRHNLSLNKCFVKVPRhyDDPGKGNYWMLDP 79

Forkhead (FH) domain found in Forkhead box proteins, FOXJ2, FOXJ3 and similar proteins; The FOXJ2-like subfamily includes two winged helix transcription factors, FOXJ2 and FOXJ3. FOXJ2, also called Forkhead homologous X (FHX), plays an important role in tumorigenesis, progression, and metastasis of certain cancers. It acts as a transcriptional activator that can bind to two different type of DNA binding sites. FOXJ3 is a transcription factor which regulates sperm function. It transcriptionally activates Mef2c and regulates adult skeletal muscle fiber type identity. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 767977483  23 AQNCWcQNSIRHNLSLHSKFIRV--QNEGTGKSSWWML 58
Cdd:cd20024   41 AGTGW-KNSIRHNLSLNKCFKKVprSKDDPGKGSYWTL 77

Forkhead (FH) domain found in Forkhead box protein D4 (FOXD4) and similar proteins; FOXD4, also called Forkhead-related protein FKHL9, Forkhead-related transcription factor 5 (FREAC-5), or myeloid factor-alpha, is essential for establishing neural cell fate and for neuronal differentiation. The family also includes Forkhead box protein D4-like proteins, FOXD4L1-6. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767977483  29 QNSIRHNLSLHSKFIRVQNE--GTGKSSWWMLNPEggksgksprrrAASMDNNSKFAKSRSR 88
Cdd:cd20048   46 QNSIRHNLSLNDCFVKIPREpgHPGKGNYWSLDPA-----------SQDMFDNGSFLRRRKR 96

Forkhead (FH) domain found in Forkhead box protein Q1 (FOXQ1) and similar proteins; FOXQ1, also called HNF-3/Forkhead-like protein 1 (HFH-1), or hepatocyte nuclear factor 3 Forkhead homolog 1, plays a role in hair follicle differentiation. It has also been reported to promote epithelial differentiation, inhibit smooth muscle differentiation, activate T cells and autoimmunity, and control mucin gene expression and granule content in stomach surface mucous cells. FOXQ1 is significantly associated with the pathogenesis of various tumor types including gastric, breast, colorectal, pancreatic, bladder and ovarian cancer, and glioma. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 767977483  27 WcQNSIRHNLSLHSKFIRVQNEGT---GKSSWWMLN 59
Cdd:cd20034   45 W-RNSVRHNLSLNDCFVKVLRDPSrpwGKDNYWTIN 79

Forkhead (FH) domain found in Forkhead box protein C2 (FOXC2) and similar proteins; FOXC2, also called Forkhead-related protein FKHL14, Mesenchyme fork head protein 1 (MFH-1 protein), or transcription factor FKH-14, acts as a transcriptional activator that might be involved in the formation of special mesenchymal tissues. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30
                 ....*....|....*....|....*....|....*
gi 767977483  29 QNSIRHNLSLHSKFIRV--QNEGTGKSSWWMLNPE 61
Cdd:cd20045   48 QNSIRHNLSLNECFVKVprDDKKPGKGSYWTLDPD 82

Forkhead (FH) domain found in Forkhead box protein C1 (FOXC1) and similar proteins; FOXC1, also called Forkhead-related protein FKHL7, or Forkhead-related transcription factor 3 (FREAC-3), is a DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as the development of the eyes, bones, cardiovascular system, kidneys, and skin. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30
                 ....*....|....*....|....*....|....*
gi 767977483  29 QNSIRHNLSLHSKFIRV--QNEGTGKSSWWMLNPE 61
Cdd:cd20044   51 QNSIRHNLSLNECFVKVprDDKKPGKGSYWTLDPD 85

Forkhead (FH) domain found in Forkhead box protein K2 (FOXK2) and similar proteins; FOXK2, also called cellular transcription factor ILF-1 or interleukin enhancer-binding factor 1, is a transcriptional regulator that recognizes the core sequence 5'-TAAACA-3'. It binds to NFAT-like motifs (purine-rich) in the IL2 promoter. It also binds to the HIV-1 long terminal repeat. FOXK2 may be involved in both, positive and negative regulation of important viral and cellular promoter elements. In addition, FOXK2 plays a critical role in suppressing tumorigenesis. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 767977483  23 AQNCWcQNSIRHNLSLHSKFIRV--QNEGTGKSSWWMLNP 60
Cdd:cd20055   43 ADKGW-QNSIRHNLSLNRYFIKVprSQEEPGKGSFWRIDP 81

Forkhead (FH) domain found in the Forkhead box protein B (FOXB) subfamily; The FOXB subfamily includes two winged helix transcription factors, FOXB1 (also called transcription factor FKH-5) and FOXB2 (also called transcription factor FKH-4). FOXB1 controls development of mammary glands and regions of the central nervous system (CNS) that regulate the milk-ejection reflex. It is essential for access of mammillothalamic axons to the thalamus. FOXB2 may act as a tumor suppressor; it has been found to inhibit the malignant characteristics of the pancreatic cancer cell line Panc-1 in vitro. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30
                 ....*....|....*....|....*....|....
gi 767977483  29 QNSIRHNLSLHSKFIRVQNEGT--GKSSWWMLNP 60
Cdd:cd20016   46 QNSLRHNLSFNDCFIKIPRRPDrpGKGSYWALHP 79

Forkhead (FH) domain found in Drosophila melanogaster protein fork head (dFKH) and similar proteins; dFKH promotes terminal as opposed to segmental development. In the absence of dFKH, this developmental switch does not occur. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 767977483  24 QNCWcQNSIRHNLSLHSKFIRVQN--EGTGKSSWWMLNPEGG 63
Cdd:cd20041   42 QQRW-QNSIRHSLSFNDCFVKVPRtpDKPGKGSFWTLHPDSG 82

Forkhead (FH) domain found in the Forkhead box protein I (FOXI) subfamily; The FOXI subfamily includes three human winged helix transcription factors, FOXI1-3, Xenopus laevis FoxI1c, and similar proteins. FOXI1 acts as a transcriptional activator required for the development of normal hearing, sense of balance, and kidney function. FOXI2 may act as a transcriptional activator that plays a possible role in controlling cellular identity. Loss of function mutations in the FOXI2 gene may contribute to ectodermal dysplasia. FOXI3 plays a critical role in the development of the inner ear and jaw. It is a regulator of ectodermal development. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30
                 ....*....|....*....|....*....|...
gi 767977483  29 QNSIRHNLSLHSKFIRV--QNEGTGKSSWWMLN 59
Cdd:cd20025   45 QNSIRHNLSLNDCFKKVprDEDDPGKGNYWTLD 77

Forkhead (FH) domain found in the Forkhead box protein P (FOXP) subfamily; The FOXP subfamily includes four winged helix transcription factors, FOXP1-4. They are involved in the development of the central nervous system. Mutations in FOXP1, also called Mac-1-regulated Forkhead (MFH), leads to developmental delay, intellectual disability, autism spectrum disorder, speech delay, and dysmorphic features. FOXP2, also called CAG repeat protein 44 or Trinucleotide repeat-containing gene 10 protein, is a transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. It may also play a role in developing neural, gastrointestinal and cardiovascular tissues. FOXP3, also called Scurfin, is a transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). FOXP4, also called Forkhead-related protein-like A, is a transcriptional repressor that represses lung-specific expression. It is necessary for normal T cell cytokine recall responses to antigen following pathogenic infection. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30
                 ....*....|....*....|....*....|...
gi 767977483  27 WcQNSIRHNLSLHSKFIRVQNegtGKSSWWMLN 59
Cdd:cd20033   45 W-KNAVRHNLSLHKCFVRVEN---VKGAVWTVD 73

Forkhead (FH) domain found in Forkhead box protein N1 (FOXN1) and similar proteins; The FOXN1-like group includes two FOXN subfamily winged helix transcription factors, FOXN1 and FOXN4. FOXN1, also called winged helix transcription factor nude, acts as a transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs), both in the prenatal and postnatal thymus. FOXN4 acts as a transcription factor essential for neural and some non-neural tissue development, such as retina and lung, respectively. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 767977483  29 QNSIRHNLSLHSKFIRVQNEGTG----KSSWWMLNP 60
Cdd:cd20030   46 KNSVRHNLSLNKCFEKIERPDGNgssrKGCLWALNP 81

Forkhead (FH) domain found in Forkhead box protein J3 (FOXJ3) and similar proteins; FOXJ3 is a transcription factor which regulates sperm function. It transcriptionally activates Mef2c and regulates adult skeletal muscle fiber type identity. Polymorphisms in the FOXJ3 gene may be associated with the development of rheumatoid arthritis. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 767977483  23 AQNCWcQNSIRHNLSLHSKFIRV--QNEGTGKSSWWMLN 59
Cdd:cd20052   42 AGNGW-KNSIRHNLSLNKCFLKVprSKDDPGKGSYWAID 79

Forkhead (FH) domain found in the Forkhead box protein D (FOXD) subfamily; The FOXD subfamily includes four winged helix transcription factors, FOXD1-4. FOXD1, also called Forkhead-related protein FKHL8 or Forkhead-related transcription factor 4 (FREAC-4), is involved in transcriptional activation of Placental Growth Factor (PGF) and the complement component (C3) genes. It plays an important role in early embryonic development and organogenesis, and functions as an oncogene in several cancers. FOXD2, also called Forkhead-related protein FKHL17 or Forkhead-related transcription factor 9 (FREAC-9), is a probable transcription factor involved in embryogenesis and somatogenesis. FOXD3, also called HNF3/FH transcription factor genesis, acts as a transcriptional repressor that binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3'. It also acts as a transcriptional activator. It promotes development of neural crest cells from neural tube progenitors and restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. FOXD3 is required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis. FOXD4, also called Forkhead-related protein FKHL9 or Forkhead-related transcription factor 5 (FREAC-5), is essential for establishing neural cell fate and for neuronal differentiation. The family also includes Forkhead box protein D4-like proteins, FOXD4L1-6. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30
                 ....*....|....*....|....*....|...
gi 767977483  29 QNSIRHNLSLHSKFIRVQNE--GTGKSSWWMLN 59
Cdd:cd20018   46 QNSIRHNLSLNDCFVKIPREpgNPGKGNYWTLD 78

Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2); FOXN2, also called human T-cell leukemia virus enhancer factor (HTLF), is a potential tumor suppressor that can facilitate replication fork reversal. It acts as a transcription factor that binds to the purine-rich region in human T-cell leukemia virus long terminal repeat (HTLV-I LTR). It may be a potential therapeutic and radiosensitization target for lung cancer. FOXN2 has also been found to be down-regulated in breast cancer, where it regulates migration, invasion, and epithelial-mesenchymal transition. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977483   1 MRSKHTAN-CLAFRCILAW-----PGGLAQNCWCQNSIRHNLSLHSKFIRVQ---NEGTGKSSWWMLNPE 61
Cdd:cd20058   13 MAIEHSPNkCLPVKEIYSWilehfPYFSTAPTGWKNSVRHNLSLNKCFRKVErshGKVNGKGSLWCVDPE 82