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Conserved domains on  [gi|767978276|ref|XP_011533619|]
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peptide chain release factor 1, mitochondrial isoform X3 [Homo sapiens]

Protein Classification

peptide chain release factor 1( domain architecture ID 1907968)

peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA

CATH:  3.30.160.20|3.30.70.1660|1.10.287.4000
Gene Ontology:  GO:0003747|GO:0016149
SCOP:  4002864|4002570

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PrfA super family cl43066
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 92-449 1.79e-137

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


The actual alignment was detected with superfamily member COG0216:

Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 398.99  E-value: 1.79e-137
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276  92 MENLSKEYQTLEQCLQ--HIPVNEENRRSLNRRHAELAPLAAIYQEIQETEQAIEELESMcksLNKQDEKQLQELALEER 169
Cdd:COG0216    6 LEALEERYEELEALLSdpEVISDQKRFRKLSKEYAELEPIVEAYREYKKLLEDIEEAKEL---LEEESDPEMREMAKEEL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276 170 QTIDQKINMLYNELFQSLVPKEKYDKNDVILEVTAGrtTGGD---IcqqFTREIFDMYQNYSCYKHWQFELLNYTPADYG 246
Cdd:COG0216   83 EELEARLEELEEELKILLLPKDPNDDKNVILEIRAG--TGGDeaaL---FAGDLFRMYSRYAERKGWKVEILSASEGELG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276 247 GLHHAAARISGDGVYKHLKYEGGIHRVQRIPEV---GlssrmqRIHTGTMSVIVLPQPDEVDVKLDPKDLRIDTFRAKGA 323
Cdd:COG0216  158 GYKEVIFRISGEGVYSRLKFESGVHRVQRVPETesqG------RIHTSAATVAVLPEAEEVDVEINPKDLRIDTFRSSGA 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276 324 GGQHVNKTDSAVRLVHIPTGLVVECQQERSQIKNKEIAFRVLRARLYQQIIEKDKRQQQSARKLQVGTRAQSERIRTYNF 403
Cdd:COG0216  232 GGQHVNTTDSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQKQQAEIAAERKSQVGSGDRSERIRTYNF 311

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 767978276 404 TQDRVSDHRIAYEVRDIKEFLCGgkGLDQLIQRLLQSADEEAIAEL 449
Cdd:COG0216  312 PQGRVTDHRINLTLYKLDEVMEG--DLDELIDALIAEDQAEKLAAL 355
 
Name Accession Description Interval E-value
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 92-449 1.79e-137

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 398.99  E-value: 1.79e-137
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276  92 MENLSKEYQTLEQCLQ--HIPVNEENRRSLNRRHAELAPLAAIYQEIQETEQAIEELESMcksLNKQDEKQLQELALEER 169
Cdd:COG0216    6 LEALEERYEELEALLSdpEVISDQKRFRKLSKEYAELEPIVEAYREYKKLLEDIEEAKEL---LEEESDPEMREMAKEEL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276 170 QTIDQKINMLYNELFQSLVPKEKYDKNDVILEVTAGrtTGGD---IcqqFTREIFDMYQNYSCYKHWQFELLNYTPADYG 246
Cdd:COG0216   83 EELEARLEELEEELKILLLPKDPNDDKNVILEIRAG--TGGDeaaL---FAGDLFRMYSRYAERKGWKVEILSASEGELG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276 247 GLHHAAARISGDGVYKHLKYEGGIHRVQRIPEV---GlssrmqRIHTGTMSVIVLPQPDEVDVKLDPKDLRIDTFRAKGA 323
Cdd:COG0216  158 GYKEVIFRISGEGVYSRLKFESGVHRVQRVPETesqG------RIHTSAATVAVLPEAEEVDVEINPKDLRIDTFRSSGA 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276 324 GGQHVNKTDSAVRLVHIPTGLVVECQQERSQIKNKEIAFRVLRARLYQQIIEKDKRQQQSARKLQVGTRAQSERIRTYNF 403
Cdd:COG0216  232 GGQHVNTTDSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQKQQAEIAAERKSQVGSGDRSERIRTYNF 311

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 767978276 404 TQDRVSDHRIAYEVRDIKEFLCGgkGLDQLIQRLLQSADEEAIAEL 449
Cdd:COG0216  312 PQGRVTDHRINLTLYKLDEVMEG--DLDELIDALIAEDQAEKLAAL 355
prfA PRK00591
peptide chain release factor 1; Validated
 92-449 1.54e-134

peptide chain release factor 1; Validated


Pssm-ID: 234801 [Multi-domain]  Cd Length: 359  Bit Score: 391.75  E-value: 1.54e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276  92 MENLSKEYQTLEQCLQ--HIPVNEENRRSLNRRHAELAPLAAIYQEIQETEQAIEELESMcksLNKQDEKQLQELALEER 169
Cdd:PRK00591   8 LEALEERYEELEALLSdpEVISDQKRFRKLSKEYAELEPIVEAYREYKQAQEDLEEAKEM---LEEESDPEMREMAKEEL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276 170 QTIDQKINMLYNELFQSLVPKEKYDKNDVILEVTAGrtTGGDICQQFTREIFDMYQNYSCYKHWQFELLNYTPADYGGLH 249
Cdd:PRK00591  85 KELEERLEELEEELKILLLPKDPNDDKNVILEIRAG--TGGDEAALFAGDLFRMYSRYAERQGWKVEILSASEGELGGYK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276 250 HAAARISGDGVYKHLKYEGGIHRVQRIPEV---GlssrmqRIHTGTMSVIVLPQPDEVDVKLDPKDLRIDTFRAKGAGGQ 326
Cdd:PRK00591 163 EVIAEISGDGVYSKLKFESGVHRVQRVPATesqG------RIHTSAATVAVLPEAEEVEVEINPKDLRIDTFRSSGAGGQ 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276 327 HVNKTDSAVRLVHIPTGLVVECQQERSQIKNKEIAFRVLRARLYQQIIEKDKRQQQSARKLQVGTRAQSERIRTYNFTQD 406
Cdd:PRK00591 237 HVNTTDSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYDAERQKAQAEEAATRKSQVGSGDRSERIRTYNFPQG 316

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 767978276 407 RVSDHRIAYEVRDIKEFLCGgkGLDQLIQRLLQSADEEAIAEL 449
Cdd:PRK00591 317 RVTDHRINLTLYKLDEVMEG--DLDELIDALIAEDQAEKLAAL 357
prfA TIGR00019
peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, ...
 86-452 9.19e-113

peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, RF-1), and excludes the related peptide chain release factor 2 (PrfB, RF-2). RF-1 helps recognize and terminate translation at UAA and UAG stop codons. The mitochondrial release factors are prfA-like, although not included above the trusted cutoff for this model. RF-1 does not have a translational frameshift. [Protein synthesis, Translation factors]


Pssm-ID: 129130 [Multi-domain]  Cd Length: 360  Bit Score: 336.28  E-value: 9.19e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276   86 KALQKYMENLSKEYQTLEQCLQHIPV--NEENRRSLNRRHAELAPLAAIYQEIQETEQAIEELESMCKSlnkqDEKQLQE 163
Cdd:TIGR00019   3 PSLLEKLESLLERYEELEALLSDPEVisDQDKLRKLSKEYSQLEEIVDCYREYQQAQEDIKEAKEILEE----SDPEMRE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276  164 LALEERQTIDQKINMLYNELFQSLVPKEKYDKNDVILEVTAGrtTGGDICQQFTREIFDMYQNYSCYKHWQFELLNYTPA 243
Cdd:TIGR00019  79 MAKEELEELEEKIEELEEQLKVLLLPKDPNDEKNVILEIRAG--TGGDEAAIFAGDLFRMYSRYAESKGWKVEILSANET 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276  244 DYGGLHHAAARISGDGVYKHLKYEGGIHRVQRIPEvglSSRMQRIHTGTMSVIVLPQPDEVDVKLDPKDLRIDTFRAKGA 323
Cdd:TIGR00019 157 ELGGYKEVIAEIKGDGVYSRLKFESGVHRVQRVPV---TESQGRIHTSAATVAVMPELEEVEVDINPADLRIDTFRSSGA 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276  324 GGQHVNKTDSAVRLVHIPTGLVVECQQERSQIKNKEIAFRVLRARLYQQIIEKDKRQQQSARKLQVGTRAQSERIRTYNF 403
Cdd:TIGR00019 234 GGQHVNTTDSAVRITHLPTGIVVECQDERSQHKNKDKAMKVLRARLYEAEQEKQQAAQASTRKSQVGSGDRSERIRTYNF 313

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 767978276  404 TQDRVSDHRIAYEVRDIKEFLCGgkGLDQLIQRLLQSADEEAIAELLDE 452
Cdd:TIGR00019 314 PQNRVTDHRINLTLYKLDEVLEG--DLDELIEALIAEDQAQQLAALSEE 360
PCRF pfam03462
PCRF domain; This domain is found in peptide chain release factors.
 95-295 2.13e-64

PCRF domain; This domain is found in peptide chain release factors.


Pssm-ID: 460929 [Multi-domain]  Cd Length: 192  Bit Score: 205.69  E-value: 2.13e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276   95 LSKEYQTLEQCLQHIPV--NEENRRSLNRRHAELAPLAAIYQEIQETEQAIEELESMCKslnkqdEKQLQELALEERQTI 172
Cdd:pfam03462   1 LEERYEELEALLSDPDVwdDQKRAQKLSKEYSELEPIVEAYREYKQALEDLEEAKELLE------DPELAELAEEELEEL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276  173 DQKINMLYNELFQSLVPKEKYDKNDVILEVTAGrtTGGDICQQFTREIFDMYQNYSCYKHWQFELLNYTPADYGGLHHAA 252
Cdd:pfam03462  75 EKRLEELEEELKLLLLPKDPNDDKNAILEIRAG--AGGDEAALFAGDLFRMYTRYAERKGWKVEVLDYSETEAGGIKEAT 152

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 767978276  253 ARISGDGVYKHLKYEGGIHRVQRIPEvglSSRMQRIHTGTMSV 295
Cdd:pfam03462 153 FEISGEGAYGRLKFESGVHRVQRVPP---TESQGRIHTSFATV 192
PCRF smart00937
This domain is found in peptide chain release factors;
151-267 1.23e-34

This domain is found in peptide chain release factors;


Pssm-ID: 214923 [Multi-domain]  Cd Length: 116  Bit Score: 125.27  E-value: 1.23e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276   151 KSLNKQDEKQLQELALEERQTI-DQKINMLYNELFQSLVPKEKYDKNDVILEVTAGrtTGGDICQQFTREIFDMYQNYSC 229
Cdd:smart00937   1 ELLEEEEDDEMRELAEEELEELeAELEEELEELLKLLLLPKDPNDDKNAILEIRAG--AGGDEAALFAGDLLRMYLRYAE 78

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 767978276   230 YKHWQFELLNYTPADYGGLHHAAARISGDGVYKHLKYE 267
Cdd:smart00937  79 RKGWKVEVLDESEGELGGIKEATLKISGEGAYGKLKFE 116
 
Name Accession Description Interval E-value
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 92-449 1.79e-137

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 398.99  E-value: 1.79e-137
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276  92 MENLSKEYQTLEQCLQ--HIPVNEENRRSLNRRHAELAPLAAIYQEIQETEQAIEELESMcksLNKQDEKQLQELALEER 169
Cdd:COG0216    6 LEALEERYEELEALLSdpEVISDQKRFRKLSKEYAELEPIVEAYREYKKLLEDIEEAKEL---LEEESDPEMREMAKEEL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276 170 QTIDQKINMLYNELFQSLVPKEKYDKNDVILEVTAGrtTGGD---IcqqFTREIFDMYQNYSCYKHWQFELLNYTPADYG 246
Cdd:COG0216   83 EELEARLEELEEELKILLLPKDPNDDKNVILEIRAG--TGGDeaaL---FAGDLFRMYSRYAERKGWKVEILSASEGELG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276 247 GLHHAAARISGDGVYKHLKYEGGIHRVQRIPEV---GlssrmqRIHTGTMSVIVLPQPDEVDVKLDPKDLRIDTFRAKGA 323
Cdd:COG0216  158 GYKEVIFRISGEGVYSRLKFESGVHRVQRVPETesqG------RIHTSAATVAVLPEAEEVDVEINPKDLRIDTFRSSGA 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276 324 GGQHVNKTDSAVRLVHIPTGLVVECQQERSQIKNKEIAFRVLRARLYQQIIEKDKRQQQSARKLQVGTRAQSERIRTYNF 403
Cdd:COG0216  232 GGQHVNTTDSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQKQQAEIAAERKSQVGSGDRSERIRTYNF 311

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 767978276 404 TQDRVSDHRIAYEVRDIKEFLCGgkGLDQLIQRLLQSADEEAIAEL 449
Cdd:COG0216  312 PQGRVTDHRINLTLYKLDEVMEG--DLDELIDALIAEDQAEKLAAL 355
prfA PRK00591
peptide chain release factor 1; Validated
 92-449 1.54e-134

peptide chain release factor 1; Validated


Pssm-ID: 234801 [Multi-domain]  Cd Length: 359  Bit Score: 391.75  E-value: 1.54e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276  92 MENLSKEYQTLEQCLQ--HIPVNEENRRSLNRRHAELAPLAAIYQEIQETEQAIEELESMcksLNKQDEKQLQELALEER 169
Cdd:PRK00591   8 LEALEERYEELEALLSdpEVISDQKRFRKLSKEYAELEPIVEAYREYKQAQEDLEEAKEM---LEEESDPEMREMAKEEL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276 170 QTIDQKINMLYNELFQSLVPKEKYDKNDVILEVTAGrtTGGDICQQFTREIFDMYQNYSCYKHWQFELLNYTPADYGGLH 249
Cdd:PRK00591  85 KELEERLEELEEELKILLLPKDPNDDKNVILEIRAG--TGGDEAALFAGDLFRMYSRYAERQGWKVEILSASEGELGGYK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276 250 HAAARISGDGVYKHLKYEGGIHRVQRIPEV---GlssrmqRIHTGTMSVIVLPQPDEVDVKLDPKDLRIDTFRAKGAGGQ 326
Cdd:PRK00591 163 EVIAEISGDGVYSKLKFESGVHRVQRVPATesqG------RIHTSAATVAVLPEAEEVEVEINPKDLRIDTFRSSGAGGQ 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276 327 HVNKTDSAVRLVHIPTGLVVECQQERSQIKNKEIAFRVLRARLYQQIIEKDKRQQQSARKLQVGTRAQSERIRTYNFTQD 406
Cdd:PRK00591 237 HVNTTDSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYDAERQKAQAEEAATRKSQVGSGDRSERIRTYNFPQG 316

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 767978276 407 RVSDHRIAYEVRDIKEFLCGgkGLDQLIQRLLQSADEEAIAEL 449
Cdd:PRK00591 317 RVTDHRINLTLYKLDEVMEG--DLDELIDALIAEDQAEKLAAL 357
prfA TIGR00019
peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, ...
 86-452 9.19e-113

peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, RF-1), and excludes the related peptide chain release factor 2 (PrfB, RF-2). RF-1 helps recognize and terminate translation at UAA and UAG stop codons. The mitochondrial release factors are prfA-like, although not included above the trusted cutoff for this model. RF-1 does not have a translational frameshift. [Protein synthesis, Translation factors]


Pssm-ID: 129130 [Multi-domain]  Cd Length: 360  Bit Score: 336.28  E-value: 9.19e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276   86 KALQKYMENLSKEYQTLEQCLQHIPV--NEENRRSLNRRHAELAPLAAIYQEIQETEQAIEELESMCKSlnkqDEKQLQE 163
Cdd:TIGR00019   3 PSLLEKLESLLERYEELEALLSDPEVisDQDKLRKLSKEYSQLEEIVDCYREYQQAQEDIKEAKEILEE----SDPEMRE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276  164 LALEERQTIDQKINMLYNELFQSLVPKEKYDKNDVILEVTAGrtTGGDICQQFTREIFDMYQNYSCYKHWQFELLNYTPA 243
Cdd:TIGR00019  79 MAKEELEELEEKIEELEEQLKVLLLPKDPNDEKNVILEIRAG--TGGDEAAIFAGDLFRMYSRYAESKGWKVEILSANET 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276  244 DYGGLHHAAARISGDGVYKHLKYEGGIHRVQRIPEvglSSRMQRIHTGTMSVIVLPQPDEVDVKLDPKDLRIDTFRAKGA 323
Cdd:TIGR00019 157 ELGGYKEVIAEIKGDGVYSRLKFESGVHRVQRVPV---TESQGRIHTSAATVAVMPELEEVEVDINPADLRIDTFRSSGA 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276  324 GGQHVNKTDSAVRLVHIPTGLVVECQQERSQIKNKEIAFRVLRARLYQQIIEKDKRQQQSARKLQVGTRAQSERIRTYNF 403
Cdd:TIGR00019 234 GGQHVNTTDSAVRITHLPTGIVVECQDERSQHKNKDKAMKVLRARLYEAEQEKQQAAQASTRKSQVGSGDRSERIRTYNF 313

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 767978276  404 TQDRVSDHRIAYEVRDIKEFLCGgkGLDQLIQRLLQSADEEAIAELLDE 452
Cdd:TIGR00019 314 PQNRVTDHRINLTLYKLDEVLEG--DLDELIEALIAEDQAQQLAALSEE 360
prfB TIGR00020
peptide chain release factor 2; In many but not all taxa, there is a conserved real ...
 125-440 4.31e-67

peptide chain release factor 2; In many but not all taxa, there is a conserved real translational frameshift at a TGA codon. RF-2 helps terminate translation at TGA codons and can therefore regulate its own production by readthrough when RF-2 is insufficient. There is a Pfam model called "RF-1" for the superfamily of RF-1, RF-2, mitochondrial, RF-H, etc. [Protein synthesis, Translation factors]


Pssm-ID: 272858 [Multi-domain]  Cd Length: 364  Bit Score: 218.88  E-value: 4.31e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276  125 ELAPLAAIYQEIQETEQAIEELESMCKSLNKQDEKQLQELALEERQTIDQKINMLyneLFQSLVpKEKYDKNDVILEVTA 204
Cdd:TIGR00020  57 ERSSLEAVLDTLEELKNSLEDLSELLELAVEEDDEETFNELDAELKALEKKLAEL---ELRTML-SGEYDANNAYLTIQA 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276  205 GrtTGGDICQQFTREIFDMYQNYSCYKHWQFELLNYTPADYGGLHHAAARISGDGVYKHLKYEGGIHRVQRIPEVGLSSR 284
Cdd:TIGR00020 133 G--AGGTEAQDWASMLYRMYLRWAERRGFKVEIIDYSEGEEAGIKSVTILIKGPYAYGYLKSEQGVHRLVRISPFDANGR 210

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276  285 MqriHTGTMSVIVLPQ-PDEVDVKLDPKDLRIDTFRAKGAGGQHVNKTDSAVRLVHIPTGLVVECQQERSQIKNKEIAFR 363
Cdd:TIGR00020 211 R---HTSFASVFVMPEvDDDIDIEIKPEDLRIDTYRASGAGGQHVNKTDSAVRITHIPTGIVVQCQNDRSQHKNKDSAMK 287

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276  364 VLRARLYQQIIEKdkrqQQSARKLQVGTRAQS---ERIRTYNF-TQDRVSDHRIAYEVRDIKEFLCGgkGLDQLIQRLLQ 439
Cdd:TIGR00020 288 VLKAKLYELEMEK----EQAEKDAKEGEKSEIgwgSQIRSYVLhPYSMVKDLRTGYETGNVQAVLDG--DIDQFIEAYLK 361


                  .
gi 767978276  440 S 440
Cdd:TIGR00020 362 W 362
PCRF pfam03462
PCRF domain; This domain is found in peptide chain release factors.
 95-295 2.13e-64

PCRF domain; This domain is found in peptide chain release factors.


Pssm-ID: 460929 [Multi-domain]  Cd Length: 192  Bit Score: 205.69  E-value: 2.13e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276   95 LSKEYQTLEQCLQHIPV--NEENRRSLNRRHAELAPLAAIYQEIQETEQAIEELESMCKslnkqdEKQLQELALEERQTI 172
Cdd:pfam03462   1 LEERYEELEALLSDPDVwdDQKRAQKLSKEYSELEPIVEAYREYKQALEDLEEAKELLE------DPELAELAEEELEEL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276  173 DQKINMLYNELFQSLVPKEKYDKNDVILEVTAGrtTGGDICQQFTREIFDMYQNYSCYKHWQFELLNYTPADYGGLHHAA 252
Cdd:pfam03462  75 EKRLEELEEELKLLLLPKDPNDDKNAILEIRAG--AGGDEAALFAGDLFRMYTRYAERKGWKVEVLDYSETEAGGIKEAT 152

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 767978276  253 ARISGDGVYKHLKYEGGIHRVQRIPEvglSSRMQRIHTGTMSV 295
Cdd:pfam03462 153 FEISGEGAYGRLKFESGVHRVQRVPP---TESQGRIHTSFATV 192
RF-1 pfam00472
RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and ...
 302-412 7.33e-58

RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and a number of smaller proteins of unknown function. This domain contains the peptidyl-tRNA hydrolase activity. The domain contains a highly conserved motif GGQ, where the glutamine is thought to coordinate the water that mediates the hydrolysis.


Pssm-ID: 459823 [Multi-domain]  Cd Length: 111  Bit Score: 186.09  E-value: 7.33e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276  302 DEVDVKLDPKDLRIDTFRAKGAGGQHVNKTDSAVRLVHIPTGLVVECQQERSQIKNKEIAFRVLRARLYQqiIEKDKRQQ 381
Cdd:pfam00472   1 DEIEIEIDPKDLRIDTFRSSGAGGQHVNKTDSAVRLTHIPTGIVVKCQDERSQHQNREKALKRLRARLYE--LEEEKEEE 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 767978276  382 QSAR-KLQVGTRAQSERIRTYNFT-QDRVSDHR 412
Cdd:pfam00472  79 KKRRiKSQVGSGDRSEQIRTYNFKpQSRVKDHR 111
PRK05589 PRK05589
peptide chain release factor 2; Provisional
 139-420 6.66e-52

peptide chain release factor 2; Provisional


Pssm-ID: 235520 [Multi-domain]  Cd Length: 325  Bit Score: 178.07  E-value: 6.66e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276 139 TEQAIEELESMCKSLNKQDEKQLQELaLEERQTIDQKINMLYNELFQSlvpkEKYDKNDVILEVTAGrtTGGDICQQFTR 218
Cdd:PRK05589  33 LRNRIEDIEVLCEMMSEEDDEMKKEI-ISEVKNIKEEIDRFKIETLLS----GEYDRNNAILTLHSG--VGGTDAQDWTE 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276 219 EIFDMYQNYSCYKHWQFELLNYTPADYGGLHHAAARISGDGVYKHLKYEGGIHRVQRIPEVGLSSRMQrihTGTMSVIVL 298
Cdd:PRK05589 106 MLLRMYTRWAEKKGYKVEIIDLLEGDEAGIKSVTLKITGEFAYGYLKAEKGIHRLVRISPFNANGKRQ---TSFASVEVL 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276 299 PQ-PDEVDVKLDPKDLRIDTFRAKGAGGQHVNKTDSAVRLVHIPTGLVVECQQERSQIKNKEIAFRVLRARLYQ--QIIE 375
Cdd:PRK05589 183 PElTDDQDIEIRSEDLKIDTYRAGGAGGQHVNKTESAVRITHIPTGIVVQCQNERSQHSNKETAMKMLKSKLVElkERAH 262

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 767978276 376 KDKRQQQSARKLQVGTRAQserIRTYNF-TQDRVSDHRIAYEVRDI 420
Cdd:PRK05589 263 KEKIEDLTGELKDMGWGSQ---IRSYVFhPYNLVKDHRTGVETSNV 305
PRK08787 PRK08787
peptide chain release factor 2; Provisional
 124-441 4.86e-51

peptide chain release factor 2; Provisional


Pssm-ID: 136970 [Multi-domain]  Cd Length: 313  Bit Score: 175.23  E-value: 4.86e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276 124 AELAPLAAIYQEiQETEQAIeelesmcksLNKQDEKQLQELALEerqtidqkinmlYNELFQSlvpkeKYDKNDVILEVT 203
Cdd:PRK08787  20 GELLDLAESEQD-EDTALAV---------IADLDKYQAHVEKLE------------FQRMFSG-----QMDGANAFVDIQ 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276 204 AGrtTGGDICQQFTREIFDMYQNYSCYKHWQFELLNYTPADYGGLHHAAARISGDGVYKHLKYEGGIHRVQRIPEVGLSS 283
Cdd:PRK08787  73 AG--AGGTEAQDWAEILLRMYLRWAESRGWKTELMEVSGGEVAGIKSATVRIEGEYAYGWLKTEIGVHRLVRKSPFDSDN 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276 284 RMqriHTGTMSVIVLPQPDE-VDVKLDPKDLRIDTFRAKGAGGQHVNKTDSAVRLVHIPTGLVVECQQERSQIKNKEIAF 362
Cdd:PRK08787 151 RR---HTSFTSVFVSPEVDDnIEIDINPADLRTDVYRSSGAGGQHVNKTESAVRITHIPTNTVVACQTGRSQHQNRDNAM 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276 363 RVLRARLYQQIIEKDKRQQQS--ARKLQVGTRAQserIRTYNFTQDRVSDHRIAYEVRDIKEFLCGgkGLDQLIQRLLQS 440
Cdd:PRK08787 228 KMLAAKLYELEVQKRNAEKDAleATKSDIGWGSQ---IRNYVLDQSRIKDLRTGIERSDTQKVLDG--DLDEFVEASLKA 302


                 .
gi 767978276 441 A 441
Cdd:PRK08787 303 G 303
PRK06746 PRK06746
peptide chain release factor 2; Provisional
 125-440 8.99e-48

peptide chain release factor 2; Provisional


Pssm-ID: 75726 [Multi-domain]  Cd Length: 326  Bit Score: 167.22  E-value: 8.99e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276 125 ELAPLAAIYQEIQETEQAIEELESMCKSLNKQDEKQLQELALEERQTIDQKINmlynELFQSLVPKEKYDKNDVILEVTA 204
Cdd:PRK06746  19 EANALKDMVGKFRQLDETFENLEITHELLKEEYDEDLHEELESEVKGLIQEMN----EYELQLLLSDPYDKNNAILELHP 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276 205 GrtTGGDICQQFTREIFDMYQNYSCYKHWQFELLNYTPADYGGLHHAAARISGDGVYKHLKYEGGIHRVQRIPEVGLSSR 284
Cdd:PRK06746  95 G--AGGTESQDWGSMLLRMYTRWAEKRGFKVETVDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDSSGR 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276 285 MqriHTGTMSVIVLPQ-PDEVDVKLDPKDLRIDTFRAKGAGGQHVNKTDSAVRLVHIPTGLVVECQQERSQIKNKEIAFR 363
Cdd:PRK06746 173 R---HTSFVSCEVVPEfNDEVEIEVRTEDLKIDTYRASGAGGQHVNTTDSAVRITHTPTNTVVTCQSERSQIKNREHAMK 249

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276 364 VLRARLYQQIIEKDKRQQQSARKLQ--VGTRAQserIRTYNF-TQDRVSDHRIAYEVRDIKEFLCGgkGLDQLIQRLLQS 440
Cdd:PRK06746 250 MLKAKLYQKKLEEQQAELDEIRGEQkeIGWGSQ---IRSYVFhPYSLVKDHRTNTEVGNVQAVMDG--EIDPFIDAYLRS 324
PRK07342 PRK07342
peptide chain release factor 2; Provisional
 134-401 1.75e-44

peptide chain release factor 2; Provisional


Pssm-ID: 235997 [Multi-domain]  Cd Length: 339  Bit Score: 158.50  E-value: 1.75e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276 134 QEIQETEQAIEELESMCKSLNkqDEKQLQELALEER-----QTIDQKINMLYNEL----FQSLVPKEKyDKNDVILEVTA 204
Cdd:PRK07342  20 RERQQLDDSINGINHLEQTLN--DNIELIAMGEEEGdksivEDAEKTIRDLKDEIdrrqIDALLSGEA-DANDTYLEVHA 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276 205 GrtTGGDICQQFTREIFDMYQNYSCYKHWQFELLNYTPADYGGLHHAAARISGDGVYKHLKYEGGIHRVQRIPEVGLSSR 284
Cdd:PRK07342  97 G--AGGTESQDWASMLLRMYTRWAERQGRKVEVLEVHDGEEAGIKSATILVKGHNAYGWLKTESGVHRLVRISPYDSNAR 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276 285 MqriHTGTMSVIVLPQPDE-VDVKLDPKDLRIDTFRAKGAGGQHVNKTDSAVRLVHIPTGLVVECQQERSQIKNKEIAFR 363
Cdd:PRK07342 175 R---HTSFASIWVYPVIDDnIEVDVNESDVRIDTYRSSGAGGQHVNTTDSAVRITHIPTGIVVQCQQERSQHKNRAKAWS 251

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 767978276 364 VLRARLYQQIIEK--DKRQQQSARKLQVGTRAQserIRTY 401
Cdd:PRK07342 252 MLRARLYEEELKKreEATNAAAASKTDIGWGHQ---IRSY 288
PCRF smart00937
This domain is found in peptide chain release factors;
151-267 1.23e-34

This domain is found in peptide chain release factors;


Pssm-ID: 214923 [Multi-domain]  Cd Length: 116  Bit Score: 125.27  E-value: 1.23e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276   151 KSLNKQDEKQLQELALEERQTI-DQKINMLYNELFQSLVPKEKYDKNDVILEVTAGrtTGGDICQQFTREIFDMYQNYSC 229
Cdd:smart00937   1 ELLEEEEDDEMRELAEEELEELeAELEEELEELLKLLLLPKDPNDDKNAILEIRAG--AGGDEAALFAGDLLRMYLRYAE 78

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 767978276   230 YKHWQFELLNYTPADYGGLHHAAARISGDGVYKHLKYE 267
Cdd:smart00937  79 RKGWKVEVLDESEGELGGIKEATLKISGEGAYGKLKFE 116
PrfB COG1186
Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein ...
 305-412 3.20e-33

Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein chain release factor PrfB is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 440799 [Multi-domain]  Cd Length: 140  Bit Score: 122.16  E-value: 3.20e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276 305 DVKLDPKDLRIDTFRAKGAGGQHVNKTDSAVRLVH------------IPTGLVVECQQERSQIKNKEIAFRVLRARLYQQ 372
Cdd:COG1186   20 EIEIPESDLRIDTYRASGAGGQNVNKVSSAVRLTHdiassslpdsrlTPGGIVVKAQEERSQHQNREDALKRLKALLYEA 99

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 767978276 373 IIEKDKRQQQSARKLQVGTRAQSERIRTynftqdRVSDHR 412
Cdd:COG1186  100 ELEPKERRATKPTRGSKKRRLWGKQIRS------MVKDLR 133
release_prfH TIGR03072
putative peptide chain release factor H; Members of this protein family are bacterial proteins ...
 310-385 8.15e-21

putative peptide chain release factor H; Members of this protein family are bacterial proteins homologous to peptide chain release factors 1 (RF-1, product of the prfA gene), and 2 (RF-2, product of the prfB gene). The member from Escherichia coli K-12, designated prfH, appears to be a pseudogene. This class I release factor is always found as the downstream gene of a two-gene operon. [Protein synthesis, Translation factors]


Pssm-ID: 213768  Cd Length: 200  Bit Score: 90.22  E-value: 8.15e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767978276  310 PKDLRIDTFRAKGAGGQHVNKTDSAVRLVHIPTGLVVECQQERSQIKNKEIAFRVLRARLYQQIIEKDKRQQQSAR 385
Cdd:TIGR03072 105 EDEIRFETLRSSGPGGQHVNKTESAVRATHLASGISVKVQSERSQHANKRLATLLLAVRLADLQQEQAAALRAERR 180
PRK09256 PRK09256
aminoacyl-tRNA hydrolase;
305-369 7.23e-09

aminoacyl-tRNA hydrolase;


Pssm-ID: 181730 [Multi-domain]  Cd Length: 138  Bit Score: 54.00  E-value: 7.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978276 305 DVKLDPKDLRIDTFRAKGAGGQHVNKTDSAVRLV------HIP---------------TG---LVVECQQERSQIKNKEI 360
Cdd:PRK09256   7 RLVIPENELEWRFIRASGPGGQNVNKVSTAVELRfdiaasSLPefykerllalaghriTKdgvIVIKAQEFRSQERNRED 86


                 ....*....
gi 767978276 361 AfrvlRARL 369
Cdd:PRK09256  87 A----LERL 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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