|
Name |
Accession |
Description |
Interval |
E-value |
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
1-282 |
2.40e-46 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 168.21 E-value: 2.40e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 1 MSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGR 80
Cdd:COG0666 9 LLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGN 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 81 SALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEV 160
Cdd:COG0666 89 TLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEI 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 161 VKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALcLELLVNNGADVNY 240
Cdd:COG0666 169 VKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEI-VKLLLEAGADLNA 247
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 767973872 241 QSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPL 282
Cdd:COG0666 248 KDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
26-305 |
5.99e-46 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 167.05 E-value: 5.99e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 26 EKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASL 105
Cdd:COG0666 1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 106 NVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIA 185
Cdd:COG0666 81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 186 CYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALcLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILI 265
Cdd:COG0666 161 AANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEI-VKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLL 239
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 767973872 266 QNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTA 305
Cdd:COG0666 240 EAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLA 279
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
125-428 |
8.63e-37 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 140.47 E-value: 8.63e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 125 LEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANV 204
Cdd:COG0666 1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 205 NQPNDKGFTPLHvAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHV 284
Cdd:COG0666 81 NAKDDGGNTLLH-AAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 285 AARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLlssgqlysivsslsnehvLSAGFDINTPDNLGRT 364
Cdd:COG0666 160 AAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLL------------------LEAGADVNAKDNDGKT 221
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767973872 365 CLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKG 428
Cdd:COG0666 222 ALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDL 285
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
3-356 |
3.03e-35 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 143.67 E-value: 3.03e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 3 GANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVN--ARDKLwqTPLHVAAANRATKCAEALAPLLSSLNVADRSgr 80
Cdd:PHA02876 168 GADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNiiALDDL--SVLECAVDSKNIDTIKAIIDNRSNINKNDLS-- 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 81 saLHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVL-KLLVARGADLGCKDRKGYGLLHTAAASG-QI 158
Cdd:PHA02876 244 --LLKAIRNEDLETSLLLYDAGFSVNSIDDCKNTPLHHASQAPSLSRLvPKLLERGADVNAKNIKGETPLYLMAKNGyDT 321
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 159 EVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDA-VAIELVNAGANVNQPNDKGFTPLHVAAVStNGALCLELLVNNGAD 237
Cdd:PHA02876 322 ENIRTLIMLGADVNAADRLYITPLHQASTLDRNKdIVITLLELGANVNARDYCDKTPIHYAAVR-NNVVIINTLLDYGAD 400
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 238 VNYQSKEGKSPLHMaAIHGR--FTRSQILIQNGSEIDCADKFGNTPLHVAARYGHEL-LISTLMTNGADTARRGIHDMFP 314
Cdd:PHA02876 401 IEALSQKIGTALHF-ALCGTnpYMSVKTLIDRGANVNSKNKDLSTPLHYACKKNCKLdVIEMLLDNGADVNAINIQNQYP 479
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 767973872 315 LHLAVlfGFSDCCRKLLSSGqlysivSSLSNEHVLSAGFDIN 356
Cdd:PHA02876 480 LLIAL--EYHGIVNILLHYG------AELRDSRVLHKSLNDN 513
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
472-751 |
4.45e-33 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 129.69 E-value: 4.45e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 472 LEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLD 551
Cdd:COG0666 2 LLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADIN 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 552 VRDHKGRTALFLATERGSTECVEVLTAHGASALIKErKRKWTPLHAAAASGHTDSLHLLIDSGerADItDVMDAYGQTPL 631
Cdd:COG0666 82 AKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARD-KDGETPLHLAAYNGNLEIVKLLLEAG--ADV-NAQDNDGNTPL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 632 MLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRT 711
Cdd:COG0666 158 HLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKL 237
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 767973872 712 LLQAALstdpLDAGVDYSGYSPMHWASYTGHEDCLELLLE 751
Cdd:COG0666 238 LLEAGA----DLNAKDKDGLTALLLAAAAGAALIVKLLLL 273
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
228-561 |
5.76e-33 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 129.69 E-value: 5.76e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 228 LELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARR 307
Cdd:COG0666 4 LLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 308 GIHDMFPLHLAVLFGFSDCCRKLLSsgqlysivsslsnehvlsAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGAD 387
Cdd:COG0666 84 DDGGNTLLHAAARNGDLEIVKLLLE------------------AGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGAD 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 388 LRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDtyrraephtpsshdaeedeplkesrRKE 467
Cdd:COG0666 146 VNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENG-------------------------HLE 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 468 AffcLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNclEDVESTIPVSPLHLAAYNGHCEALKTLAETL 547
Cdd:COG0666 201 I---VKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGAD--LNAKDKDGLTALLLAAAAGAALIVKLLLLAL 275
|
330
....*....|....
gi 767973872 548 VNLDVRDHKGRTAL 561
Cdd:COG0666 276 LLLAAALLDLLTLL 289
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
607-937 |
2.13e-32 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 127.76 E-value: 2.13e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 607 LHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFV 686
Cdd:COG0666 1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 687 LCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDpldaGVDYSGYSPMHWASYTGHEDCLELLLEHspfsylegnpftpl 766
Cdd:COG0666 81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVN----ARDKDGETPLHLAAYNGNLEIVKLLLEA-------------- 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 767 hcavinnqdsttemllgalGAKiVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAV 846
Cdd:COG0666 143 -------------------GAD-VNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIV 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 847 EFLLYRGkADLTVLDENKNTALHLACSKGHEKCALMILAEtqdLGLINATNSALQMPLHIAARNGLASVVQALLSHGATV 926
Cdd:COG0666 203 KLLLEAG-ADVNAKDNDGKTALDLAAENGNLEIVKLLLEA---GADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLL 278
|
330
....*....|.
gi 767973872 927 LAVDEEGHTPA 937
Cdd:COG0666 279 AAALLDLLTLL 289
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
3-256 |
1.72e-31 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 129.37 E-value: 1.72e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 3 GANVNAKDTLWLTPLHRAAASRNEK---VLGLLLAHSADVNARDKLWQTPLHVAAANRATkcaEALAPLL----SSLNVA 75
Cdd:PHA03095 37 GADVNFRGEYGKTPLHLYLHYSSEKvkdIVRLLLEAGADVNAPERCGFTPLHLYLYNATT---LDVIKLLikagADVNAK 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 76 DRSGRSALHhaVHSG----HLETVNLLLNKGASLNVCDKKERQPLHwaAFLGH----LEVLKLLVARGADLGCKDRKGYG 147
Cdd:PHA03095 114 DKVGRTPLH--VYLSgfniNPKVIRLLLRKGADVNALDLYGMTPLA--VLLKSrnanVELLRLLIDAGADVYAVDDRFRS 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 148 LLHTAAASGQI--EVVKYLLRMGAEIDEPNAFGNTALHIACYLG--QDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTN 223
Cdd:PHA03095 190 LLHHHLQSFKPraRIVRELIRAGCDPAATDMLGNTPLHSMATGSscKRSLVLPLLIAGISINARNRYGQTPLHYAAVFNN 269
|
250 260 270
....*....|....*....|....*....|...
gi 767973872 224 GALCLELLvNNGADVNYQSKEGKSPLHMAAIHG 256
Cdd:PHA03095 270 PRACRRLI-ALGADINAVSSDGNTPLSLMVRNN 301
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
31-298 |
3.43e-31 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 128.60 E-value: 3.43e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 31 LLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSS---LNVADRSGRSALH-HAVHSGHLETVNLLLNKGASLN 106
Cdd:PHA03095 32 RLLAAGADVNFRGEYGKTPLHLYLHYSSEKVKDIVRLLLEAgadVNAPERCGFTPLHlYLYNATTLDVIKLLIKAGADVN 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 107 VCDKKERQPLHwaAFLG----HLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQ--IEVVKYLLRMGAEIDEPNAFGNT 180
Cdd:PHA03095 112 AKDKVGRTPLH--VYLSgfniNPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNanVELLRLLIDAGADVYAVDDRFRS 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 181 ALHIAC-YLGQDA-VAIELVNAGANVNQPNDKGFTPLHVAAV-STNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGR 257
Cdd:PHA03095 190 LLHHHLqSFKPRArIVRELIRAGCDPAATDMLGNTPLHSMATgSSCKRSLVLPLLIAGISINARNRYGQTPLHYAAVFNN 269
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 767973872 258 FTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLM 298
Cdd:PHA03095 270 PRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAAL 310
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
712-954 |
3.68e-30 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 121.21 E-value: 3.68e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 712 LLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIvN 791
Cdd:COG0666 3 LLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI-N 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 792 SRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGkADLTVLDENKNTALHLA 871
Cdd:COG0666 82 AKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAG-ADVNAQDNDGNTPLHLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 872 CSKGHEKCALMILAETQDlglINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLA 951
Cdd:COG0666 161 AANGNLEIVKLLLEAGAD---VNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKL 237
|
...
gi 767973872 952 LIL 954
Cdd:COG0666 238 LLE 240
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
645-954 |
1.59e-29 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 119.67 E-value: 1.59e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 645 LLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDA 724
Cdd:COG0666 6 LLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDD 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 725 GvdysGYSPMHWASYTGHEDCLELLLEHspfsylegnpftplhcavinnqdsttemllgalGAKiVNSRDAKGRTPLHAA 804
Cdd:COG0666 86 G----GNTLLHAAARNGDLEIVKLLLEA---------------------------------GAD-VNARDKDGETPLHLA 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 805 AFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGkADLTVLDENKNTALHLACSKGHEKCALMIL 884
Cdd:COG0666 128 AYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAG-ADVNARDNDGETPLHLAAENGHLEIVKLLL 206
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 885 AETQDlglINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALIL 954
Cdd:COG0666 207 EAGAD---VNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLL 273
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
527-799 |
3.41e-29 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 118.52 E-value: 3.41e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 527 PLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGAsALIKERKRKWTPLHAAAASGHTDS 606
Cdd:COG0666 24 LLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGA-DINAKDDGGNTLLHAAARNGDLEI 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 607 LHLLIDSGerADItDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFV 686
Cdd:COG0666 103 VKLLLEAG--ADV-NARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADV 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 687 LCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAgvdySGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPFTPL 766
Cdd:COG0666 180 NARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDN----DGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTA 255
|
250 260 270
....*....|....*....|....*....|...
gi 767973872 767 HCAVINNQDSTTEMLLGALGAKIVNSRDAKGRT 799
Cdd:COG0666 256 LLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
92-384 |
7.48e-29 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 121.67 E-value: 7.48e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 92 LETVNLLLNKGASLNVCDKKERQPLHwaAFLGH-----LEVLKLLVARGADLGCKDRKGYGLLHTAAASGQ-IEVVKYLL 165
Cdd:PHA03095 27 VEEVRRLLAAGADVNFRGEYGKTPLH--LYLHYssekvKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATtLDVIKLLI 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 166 RMGAEIDEPNAFGNTALHIacYLGQDAVA---IE-LVNAGANVNQPNDKGFTPLHVAAVSTNGAL-CLELLVNNGADVNY 240
Cdd:PHA03095 105 KAGADVNAKDKVGRTPLHV--YLSGFNINpkvIRlLLRKGADVNALDLYGMTPLAVLLKSRNANVeLLRLLIDAGADVYA 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 241 QSKEGKSPLHmaaIHGRFTRS-----QILIQNGSEIDCADKFGNTPLHVAARYG--HELLISTLMTNGADTARRGIHDMF 313
Cdd:PHA03095 183 VDDRFRSLLH---HHLQSFKPrarivRELIRAGCDPAATDMLGNTPLHSMATGSscKRSLVLPLLIAGISINARNRYGQT 259
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767973872 314 PLHLAVLFGFSDCCRKLlssgqlysivsslsnehvLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSS 384
Cdd:PHA03095 260 PLHYAAVFNNPRACRRL------------------IALGADINAVSSDGNTPLSLMVRNNNGRAVRAALAK 312
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
451-697 |
1.52e-28 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 116.59 E-value: 1.52e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 451 SHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCleDVESTIPVSPLHL 530
Cdd:COG0666 49 LADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADV--NARDKDGETPLHL 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 531 AAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKrKWTPLHAAAASGHTDSLHLL 610
Cdd:COG0666 127 AAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDND-GETPLHLAAENGHLEIVKLL 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 611 IDSGerADITDVmDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRD 690
Cdd:COG0666 206 LEAG--ADVNAK-DNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAAL 282
|
....*..
gi 767973872 691 FKGRTPI 697
Cdd:COG0666 283 LDLLTLL 289
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
595-895 |
4.70e-28 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 115.05 E-value: 4.70e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 595 LHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCED 674
Cdd:COG0666 22 ALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLE 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 675 CLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAgvdySGYSPMHWASYTGHEDCLELLLEHsp 754
Cdd:COG0666 102 IVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDN----DGNTPLHLAAANGNLEIVKLLLEA-- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 755 fsylegnpftplhcavinnqdsttemllgalGAKiVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTAL 834
Cdd:COG0666 176 -------------------------------GAD-VNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTAL 223
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767973872 835 MTAAENGQTAAVEFLLYRGkADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINA 895
Cdd:COG0666 224 DLAAENGNLEIVKLLLEAG-ADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALL 283
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
125-415 |
9.71e-28 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 118.20 E-value: 9.71e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 125 LEVLKLLVARGADLGCKDRKGYGLLHTAAASGQ---IEVVKYLLRMGAEIDEPNAFGNTALHiaCYLGQDAVA--IE-LV 198
Cdd:PHA03095 27 VEEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSekvKDIVRLLLEAGADVNAPERCGFTPLH--LYLYNATTLdvIKlLI 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 199 NAGANVNQPNDKGFTPLHVAAVSTNGALC-LELLVNNGADVNYQSKEGKSPLHmaaIHGRFTRSQI-----LIQNGSEID 272
Cdd:PHA03095 105 KAGADVNAKDKVGRTPLHVYLSGFNINPKvIRLLLRKGADVNALDLYGMTPLA---VLLKSRNANVellrlLIDAGADVY 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 273 CADKFGNTPLHVAARYGH--ELLISTLMTNGADTARRGIHDMFPLHlaVLFGFSDCCRkllssgqlySIVSSLsnehvLS 350
Cdd:PHA03095 182 AVDDRFRSLLHHHLQSFKprARIVRELIRAGCDPAATDMLGNTPLH--SMATGSSCKR---------SLVLPL-----LI 245
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767973872 351 AGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYqCAVTLV 415
Cdd:PHA03095 246 AGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNG-RAVRAA 309
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
15-240 |
1.39e-27 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 116.69 E-value: 1.39e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 15 TPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRA--TKCAEALAPLLS---SLNVADRSGRSALHHAV-- 87
Cdd:PHA03100 37 LPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYnlTDVKEIVKLLLEygaNVNAPDNNGITPLLYAIsk 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 88 HSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGH--LEVLKLLVARGADLGCKDRkgygllhtaaasgqievVKYLL 165
Cdd:PHA03100 117 KSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKidLKILKLLIDKGVDINAKNR-----------------VNYLL 179
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767973872 166 RMGAEIDEPNAFGNTALHIACYlgqdAVAIELVNA----GANVNQPNDKGFTPLHVAAVSTNGALcLELLVNNGADVNY 240
Cdd:PHA03100 180 SYGVPINIKDVYGFTPLHYAVY----NNNPEFVKYlldlGANPNLVNKYGDTPLHIAILNNNKEI-FKLLLNNGPSIKT 253
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
158-599 |
1.40e-27 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 117.82 E-value: 1.40e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 158 IEVVKYLLRMGAEIDEPNAFGNTALH--IACYLGQDAVAIE-LVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNN 234
Cdd:PHA03095 27 VEEVRRLLAAGADVNFRGEYGKTPLHlyLHYSSEKVKDIVRlLLEAGADVNAPERCGFTPLHLYLYNATTLDVIKLLIKA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 235 GADVNYQskegksplhmaaihgrftrsqiliqngseidcaDKFGNTPLHVAAR--YGHELLISTLMTNGADTARRGIHDM 312
Cdd:PHA03095 107 GADVNAK---------------------------------DKVGRTPLHVYLSgfNINPKVIRLLLRKGADVNALDLYGM 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 313 FPLHlaVLFGFSDCCRKLLssgqlysivsslsnEHVLSAGFDINTPDNLGRTCLH--AAASGGNVECLNLLLSSGADLRR 390
Cdd:PHA03095 154 TPLA--VLLKSRNANVELL--------------RLLIDAGADVYAVDDRFRSLLHhhLQSFKPRARIVRELIRAGCDPAA 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 391 RDKFGRTPLHYAAANGSYQCAVT--LVTAGAGVNEADCKGCSPLHYAAASDtyrraephtpsshdaeedeplkesrrKEA 468
Cdd:PHA03095 218 TDMLGNTPLHSMATGSSCKRSLVlpLLIAGISINARNRYGQTPLHYAAVFN--------------------------NPR 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 469 FFCleFLLDNGADPSLRDRQGYTAvhyaaaygnrqnlelLLEMSFNCLEDVEST-IPVSPlhlaaynghceALKTLAETL 547
Cdd:PHA03095 272 ACR--RLIALGADINAVSSDGNTP---------------LSLMVRNNNGRAVRAaLAKNP-----------SAETVAATL 323
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 767973872 548 VNLDVRDHKGRTAlflaterGSTECVEVLTAHGASALIKERKRKwtpLHAAA 599
Cdd:PHA03095 324 NTASVAGGDIPSD-------ATRLCVAKVVLRGAFSLLPEPIRA---YHADF 365
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
349-664 |
1.47e-27 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 113.90 E-value: 1.47e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 349 LSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKG 428
Cdd:COG0666 41 LLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDG 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 429 CSPLHYAAASDTYRRAEphtpsshdaeedeplkesrrkeaffcleFLLDNGADPSLRDRQGYTavhyaaaygnrqnlell 508
Cdd:COG0666 121 ETPLHLAAYNGNLEIVK----------------------------LLLEAGADVNAQDNDGNT----------------- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 509 lemsfncledvestipvsPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKEr 588
Cdd:COG0666 156 ------------------PLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKD- 216
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767973872 589 KRKWTPLHAAAASGHTDSLHLLIDSGERADITdvmDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTAL 664
Cdd:COG0666 217 NDGKTALDLAAENGNLEIVKLLLEAGADLNAK---DKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
87-432 |
2.72e-27 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 119.01 E-value: 2.72e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 87 VHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLR 166
Cdd:PHA02876 153 IQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIID 232
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 167 MGAEIDEP-----NAFGNTALHiacylgqdaVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQ 241
Cdd:PHA02876 233 NRSNINKNdlsllKAIRNEDLE---------TSLLLYDAGFSVNSIDDCKNTPLHHASQAPSLSRLVPKLLERGADVNAK 303
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 242 SKEGKSPLHMAAIHGRFTRS-QILIQNGSEIDCADKFGNTPLHVAARYG-HELLISTLMTNGADTARRGIHDMFPLHLAV 319
Cdd:PHA02876 304 NIKGETPLYLMAKNGYDTENiRTLIMLGADVNAADRLYITPLHQASTLDrNKDIVITLLELGANVNARDYCDKTPIHYAA 383
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 320 LfgfsdccrkllssGQLYSIVSSLsnehvLSAGFDINTPDNLGRTCLHAAASGGN-VECLNLLLSSGADLRRRDKFGRTP 398
Cdd:PHA02876 384 V-------------RNNVVIINTL-----LDYGADIEALSQKIGTALHFALCGTNpYMSVKTLIDRGANVNSKNKDLSTP 445
|
330 340 350
....*....|....*....|....*....|....*
gi 767973872 399 LHYAAANG-SYQCAVTLVTAGAGVNEADCKGCSPL 432
Cdd:PHA02876 446 LHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPL 480
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
5-303 |
4.20e-27 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 115.45 E-value: 4.20e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 5 NVNAKDTLwlTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALApllssLNVADRSGRSalh 84
Cdd:PHA02874 29 NISVDETT--TPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLI-----DNGVDTSILP--- 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 85 haVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYL 164
Cdd:PHA02874 99 --IPCIEKDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 165 LRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGAlcLELLVNNgADVNYQSKE 244
Cdd:PHA02874 177 LEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRSA--IELLINN-ASINDQDID 253
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767973872 245 GKSPLHMaAIHGRFTRS--QILIQNGSEIDCADKFGNTPLHVAARYGH------ELLISTLMTNGAD 303
Cdd:PHA02874 254 GSTPLHH-AINPPCDIDiiDILLYHKADISIKDNKGENPIDTAFKYINkdpvikDIIANAVLIKEAD 319
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
72-307 |
1.91e-24 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 107.74 E-value: 1.91e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 72 LNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGAD-------------- 137
Cdd:PHA02874 28 INISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDtsilpipciekdmi 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 138 ---LGC------KDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPN 208
Cdd:PHA02874 108 ktiLDCgidvniKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKD 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 209 DKGFTPLHVAAVSTNGAlCLELLVNNGADVNYQSKEGKSPLHMAAIHGRfTRSQILIQNGSeIDCADKFGNTPLHVAARY 288
Cdd:PHA02874 188 NNGESPLHNAAEYGDYA-CIKLLIDHGNHIMNKCKNGFTPLHNAIIHNR-SAIELLINNAS-INDQDIDGSTPLHHAINP 264
|
250 260
....*....|....*....|
gi 767973872 289 GHEL-LISTLMTNGADTARR 307
Cdd:PHA02874 265 PCDIdIIDILLYHKADISIK 284
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
87-402 |
3.46e-24 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 106.97 E-value: 3.46e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 87 VHSGHLETV-NLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLL 165
Cdd:PHA02874 9 IYSGDIEAIeKIIKNKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLI 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 166 RMGAEidepnafgNTALHIACyLGQDAVAIeLVNAGANVNQPNDKGFTPLHVAaVSTNGALCLELLVNNGADVNYQSKEG 245
Cdd:PHA02874 89 DNGVD--------TSILPIPC-IEKDMIKT-ILDCGIDVNIKDAELKTFLHYA-IKKGDLESIKMLFEYGADVNIEDDNG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 246 KSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGfsd 325
Cdd:PHA02874 158 CYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHN--- 234
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767973872 326 ccrkllssgqlYSIVSSLSNEHvlsagfDINTPDNLGRTCLHAAAS-GGNVECLNLLLSSGADLRRRDKFGRTPLHYA 402
Cdd:PHA02874 235 -----------RSAIELLINNA------SINDQDIDGSTPLHHAINpPCDIDIIDILLYHKADISIKDNKGENPIDTA 295
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
2-312 |
3.09e-23 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 103.89 E-value: 3.09e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 2 SGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNArdklwqtpLHVAAANRatkcaEALAPLLSS---LNVADRS 78
Cdd:PHA02874 57 HGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDTSI--------LPIPCIEK-----DMIKTILDCgidVNIKDAE 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 79 GRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQI 158
Cdd:PHA02874 124 LKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDY 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 159 EVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNdkGFTPLHVAAVSTNGALCLELLVNNGADV 238
Cdd:PHA02874 204 ACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRSAIELLINNASINDQDID--GSTPLHHAINPPCDIDIIDILLYHKADI 281
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767973872 239 NYQSKEGKSPLHMAAIH-GRFTRSQILIQNGSEIDCADKFGNTPL--HVaaryghELLISTLMTNGADTARRGIHDM 312
Cdd:PHA02874 282 SIKDNKGENPIDTAFKYiNKDPVIKDIIANAVLIKEADKLKDSDFleHI------EIKDNKEFSDFIKECNEEIEDM 352
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
280-564 |
1.33e-22 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 101.96 E-value: 1.33e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 280 TPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSI--VSSLSNEHV---LSAGFD 354
Cdd:PHA02874 37 TPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDTSIlpIPCIEKDMIktiLDCGID 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 355 INTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHY 434
Cdd:PHA02874 117 VNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHN 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 435 AAASDTYRraephtpsshdaeedeplkesrrkeaffCLEFLLDNGADPSLRDRQGYTAVHYAAAYgNRQNLELLLEMSFN 514
Cdd:PHA02874 197 AAEYGDYA----------------------------CIKLLIDHGNHIMNKCKNGFTPLHNAIIH-NRSAIELLINNASI 247
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 767973872 515 CLEDVESTipvSPLHLA-AYNGHCEALKTLAETLVNLDVRDHKGRTALFLA 564
Cdd:PHA02874 248 NDQDIDGS---TPLHHAiNPPCDIDIIDILLYHKADISIKDNKGENPIDTA 295
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
14-297 |
2.69e-22 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 101.50 E-value: 2.69e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 14 LTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAaanratkCAE----ALAPLLSSLNVADRS-GRSALHHAVH 88
Cdd:PHA02878 38 FIPLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHII-------CKEpnklGMKEMIRSINKCSVFyTLVAIKDAFN 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 89 SGHLETVN-LLLNKGASLNVCDKKERQPLHWAAFLgHLEVLKLLVARGADLGCKDR-KGYGLLHTAAASGQIEVVKYLLR 166
Cdd:PHA02878 111 NRNVEIFKiILTNRYKNIQTIDLVYIDKKSKDDII-EAEITKLLLSYGADINMKDRhKGNTALHYATENKDQRLTELLLS 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 167 MGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSK-EG 245
Cdd:PHA02878 190 YGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVGYCKDYDILKLLLEHGVDVNAKSYiLG 269
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 767973872 246 KSPLHMaAIHGRfTRSQILIQNGSEIDCADKFGNTPLHVAA--RYGHE---LLISTL 297
Cdd:PHA02878 270 LTALHS-SIKSE-RKLKLLLEYGADINSLNSYKLTPLSSAVkqYLCINigrILISNI 324
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
515-924 |
2.29e-20 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 96.67 E-value: 2.29e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 515 CLEDVESTIPVSPLHLAAYNGHCEALKTLAETL---------------VNLDVRDHKGRTALFLATERGSTECVEVLTAH 579
Cdd:PHA02876 121 CIHILKEAISGNDIHYDKINESIEYMKLIKERIqqdelliaemlleggADVNAKDIYCITPIHYAAERGNAKMVNLLLSY 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 580 GASALIKERKrKWTPLHAAAASGHTDSLHLLIDSGERADITDVmdaygqtPLMLAIMNGHVDCVHLLLEKGSTADAADLR 659
Cdd:PHA02876 201 GADVNIIALD-DLSVLECAVDSKNIDTIKAIIDNRSNINKNDL-------SLLKAIRNEDLETSLLLYDAGFSVNSIDDC 272
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 660 GRTALHRGAVT-GCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGH-TAVLRTLLQAalstdpldaGVDYSGYSPMHwa 737
Cdd:PHA02876 273 KNTPLHHASQApSLSRLVPKLLERGADVNAKNIKGETPLYLMAKNGYdTENIRTLIML---------GADVNAADRLY-- 341
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 738 sytghedclelllehspfsylegnpFTPLHCAVINNQDSTTEMLLGALGAKiVNSRDAKGRTPLHAAAFADNVSGLRMLL 817
Cdd:PHA02876 342 -------------------------ITPLHQASTLDRNKDIVITLLELGAN-VNARDYCDKTPIHYAAVRNNVVIINTLL 395
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 818 QHQAEVNATDHTGRTALMTA--AENGQTaAVEFLLYRGkADLTVLDENKNTALHLACSKgheKCALMILAETQDLGL-IN 894
Cdd:PHA02876 396 DYGADIEALSQKIGTALHFAlcGTNPYM-SVKTLIDRG-ANVNSKNKDLSTPLHYACKK---NCKLDVIEMLLDNGAdVN 470
|
410 420 430
....*....|....*....|....*....|
gi 767973872 895 ATNSALQMPLHIAArnGLASVVQALLSHGA 924
Cdd:PHA02876 471 AINIQNQYPLLIAL--EYHGIVNILLHYGA 498
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
125-405 |
5.75e-20 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 93.96 E-value: 5.75e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 125 LEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIAC---YLGQDAVAIE--LVN 199
Cdd:PHA03100 15 VKNIKYIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSnikYNLTDVKEIVklLLE 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 200 AGANVNQPNDKGFTPLHVAAVSTNGALCL-ELLVNNGADVNYQSKEGKSPLHMAA--IHGRFTRSQILIQNGSEIDCADK 276
Cdd:PHA03100 95 YGANVNAPDNNGITPLLYAISKKSNSYSIvEYLLDNGANVNIKNSDGENLLHLYLesNKIDLKILKLLIDKGVDINAKNR 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 277 FgntplhvaaryghellistlmtngadtarrgihDMFplhlavlfgfsdccrkllssgqlysivsslsnehvLSAGFDIN 356
Cdd:PHA03100 175 V---------------------------------NYL-----------------------------------LSYGVPIN 186
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 767973872 357 TPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAAN 405
Cdd:PHA03100 187 IKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILN 235
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
2-271 |
8.89e-20 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 95.13 E-value: 8.89e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 2 SGANVNAKDTLWLTPLHRAAASRN-EKVLGLLLAHSADVNARDKLWQTPLHVAAANratkcaealapllsslnvadrsgr 80
Cdd:PHA02876 262 AGFSVNSIDDCKNTPLHHASQAPSlSRLVPKLLERGADVNAKNIKGETPLYLMAKN------------------------ 317
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 81 salhhavhsGH-LETVNLLLNKGASLNVCDKKERQPLHWAAFLG-HLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQI 158
Cdd:PHA02876 318 ---------GYdTENIRTLIMLGADVNAADRLYITPLHQASTLDrNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNV 388
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 159 EVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIE-LVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGAD 237
Cdd:PHA02876 389 VIINTLLDYGADIEALSQKIGTALHFALCGTNPYMSVKtLIDRGANVNSKNKDLSTPLHYACKKNCKLDVIEMLLDNGAD 468
|
250 260 270
....*....|....*....|....*....|....
gi 767973872 238 VNYQSKEGKSPLHMAAihGRFTRSQILIQNGSEI 271
Cdd:PHA02876 469 VNAINIQNQYPLLIAL--EYHGIVNILLHYGAEL 500
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
528-837 |
1.85e-19 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 92.33 E-value: 1.85e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 528 LHLAAYNGHCEALKTLAETLVN-LDVRDHKGRTALFLATERGSTECVEVLTAHGASalIKERKRKW-TPLHAAAASGHTD 605
Cdd:PHA02874 5 LRMCIYSGDIEAIEKIIKNKGNcINISVDETTTPLIDAIRSGDAKIVELFIKHGAD--INHINTKIpHPLLTAIKIGAHD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 606 SLHLLIDSGERADITDVMDAYGQTplmlaimnghvdcVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAF 685
Cdd:PHA02874 83 IIKLLIDNGVDTSILPIPCIEKDM-------------IKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGAD 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 686 VLCRDFKGRTPIHLASACGHTAVLRTLLQ--AALSTDpldagvDYSGYSPMHWASYTGHEDCLELLLEH-SPFSYLEGNP 762
Cdd:PHA02874 150 VNIEDDNGCYPIHIAIKHNFFDIIKLLLEkgAYANVK------DNNGESPLHNAAEYGDYACIKLLIDHgNHIMNKCKNG 223
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767973872 763 FTPLHCAVINNQdSTTEMLlgaLGAKIVNSRDAKGRTPLH-AAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTA 837
Cdd:PHA02874 224 FTPLHNAIIHNR-SAIELL---INNASINDQDIDGSTPLHhAINPPCDIDIIDILLYHKADISIKDNKGENPIDTA 295
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
83-319 |
1.31e-18 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 90.32 E-value: 1.31e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 83 LHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAF----LGHLEVLKLLVARgaDLGCKDRKgyglLHTAAASGQI 158
Cdd:PHA02878 41 LHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKepnkLGMKEMIRSINKC--SVFYTLVA----IKDAFNNRNV 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 159 EVVKYLLrmgaeIDEPNAFGNTALHIACYLGQDAVaIE------LVNAGANVNQPN-DKGFTPLHVAAVSTNGALcLELL 231
Cdd:PHA02878 115 EIFKIIL-----TNRYKNIQTIDLVYIDKKSKDDI-IEaeitklLLSYGADINMKDrHKGNTALHYATENKDQRL-TELL 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 232 VNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHEL-LISTLMTNGAD-TARRGI 309
Cdd:PHA02878 188 LSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVGYCKDYdILKLLLEHGVDvNAKSYI 267
|
250
....*....|
gi 767973872 310 HDMFPLHLAV 319
Cdd:PHA02878 268 LGLTALHSSI 277
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
528-621 |
3.26e-18 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 80.55 E-value: 3.26e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 528 LHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHgasALIKERKRKWTPLHAAAASGHTDSL 607
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH---ADVNLKDNGRTALHYAARSGHLEIV 77
|
90
....*....|....
gi 767973872 608 HLLIDSGERADITD 621
Cdd:pfam12796 78 KLLLEKGADINVKD 91
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
83-175 |
6.25e-18 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 79.77 E-value: 6.25e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 83 LHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARgADLGCKDrKGYGLLHTAAASGQIEVVK 162
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78
|
90
....*....|...
gi 767973872 163 YLLRMGAEIDEPN 175
Cdd:pfam12796 79 LLLEKGADINVKD 91
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
593-924 |
7.36e-18 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 87.77 E-value: 7.36e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 593 TPLHAAAASGHTDSLHLLIDSGERADITDVM------------DAYGQTPLMLAIMNGHVDC---VHLLLEKGSTADAAD 657
Cdd:PHA03095 1 DEEDESVDIIMEAALYDYLLNASNVTVEEVRrllaagadvnfrGEYGKTPLHLYLHYSSEKVkdiVRLLLEAGADVNAPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 658 LRGRTALH---RGAVTgcEDCLAALLDHDAFVLCRDFKGRTPIH--LASACGHTAVLRTLLQAALSTDPLDAgvdySGYS 732
Cdd:PHA03095 81 RCGFTPLHlylYNATT--LDVIKLLIKAGADVNAKDKVGRTPLHvyLSGFNINPKVIRLLLRKGADVNALDL----YGMT 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 733 PMHwaSYTGHEDC----LELLLEH-SPFSYLEGNPFTPLHCAVINNQDSTTEM-LLGALGAKiVNSRDAKGRTPLHAAAF 806
Cdd:PHA03095 155 PLA--VLLKSRNAnvelLRLLIDAgADVYAVDDRFRSLLHHHLQSFKPRARIVrELIRAGCD-PAATDMLGNTPLHSMAT 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 807 ADNVSGLRM--LLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGkADLTVLDENKNTALHLACSKGHEKCALMIL 884
Cdd:PHA03095 232 GSSCKRSLVlpLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALG-ADINAVSSDGNTPLSLMVRNNNGRAVRAAL 310
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 767973872 885 AETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGA 924
Cdd:PHA03095 311 AKNPSAETVAATLNTASVAGGDIPSDATRLCVAKVVLRGA 350
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
460-868 |
1.48e-17 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 87.81 E-value: 1.48e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 460 LKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLemSFNCLEDVESTIPVSPLHLAAYNGHCEA 539
Cdd:PHA02876 149 IKERIQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLL--SYGADVNIIALDDLSVLECAVDSKNIDT 226
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 540 LKTLAETLVNLDVRDhkgrTALFLATERGSTECVEVLTAHGASA-LIKERKRkwTPLHAAAasgHTDSLHLLIDS-GERA 617
Cdd:PHA02876 227 IKAIIDNRSNINKND----LSLLKAIRNEDLETSLLLYDAGFSVnSIDDCKN--TPLHHAS---QAPSLSRLVPKlLERG 297
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 618 DITDVMDAYGQTPLMLAIMNGH-VDCVHLLLEKGSTADAADLRGRTALHRGA-VTGCEDCLAALLDHDAFVLCRDFKGRT 695
Cdd:PHA02876 298 ADVNAKNIKGETPLYLMAKNGYdTENIRTLIMLGADVNAADRLYITPLHQAStLDRNKDIVITLLELGANVNARDYCDKT 377
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 696 PIHLASACGHTAVLRTLLQAALSTDPLDAGVDysgySPMHWASYTghedclelllehspfsyleGNPFTPLHCAVINNQD 775
Cdd:PHA02876 378 PIHYAAVRNNVVIINTLLDYGADIEALSQKIG----TALHFALCG-------------------TNPYMSVKTLIDRGAN 434
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 776 sttemllgalgakiVNSRDAKGRTPLHAAAFAD-NVSGLRMLLQHQAEVNATDHTGRTALMTAAenGQTAAVEFLLYRGK 854
Cdd:PHA02876 435 --------------VNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPLLIAL--EYHGIVNILLHYGA 498
|
410
....*....|....*.
gi 767973872 855 A--DLTVLDENKNTAL 868
Cdd:PHA02876 499 ElrDSRVLHKSLNDNM 514
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
116-208 |
1.90e-17 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 78.23 E-value: 1.90e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 116 LHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRmGAEIDEPNaFGNTALHIACYLGQDAVAI 195
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEIVK 78
|
90
....*....|...
gi 767973872 196 ELVNAGANVNQPN 208
Cdd:pfam12796 79 LLLEKGADINVKD 91
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
80-239 |
3.14e-17 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 85.43 E-value: 3.14e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 80 RSALHHAVHSGHLETVNLLLNKGASLN-VCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQI 158
Cdd:PHA02875 69 ESELHDAVEEGDVKAVEELLDLGKFADdVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDI 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 159 EVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADV 238
Cdd:PHA02875 149 KGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAALCYAIENNKIDIVRLFIKRGADC 228
|
.
gi 767973872 239 N 239
Cdd:PHA02875 229 N 229
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
50-142 |
3.50e-17 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 77.46 E-value: 3.50e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 50 LHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKgASLNVCDKKeRQPLHWAAFLGHLEVLK 129
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNG-RTALHYAARSGHLEIVK 78
|
90
....*....|...
gi 767973872 130 LLVARGADLGCKD 142
Cdd:pfam12796 79 LLLEKGADINVKD 91
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
538-846 |
3.67e-17 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 85.46 E-value: 3.67e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 538 EALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEV---LTAHGASALIKERKrKWTPLHAAAASGHT-DSLHLLIDS 613
Cdd:PHA03095 28 EEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVKDIvrlLLEAGADVNAPERC-GFTPLHLYLYNATTlDVIKLLIKA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 614 GerADITDVmDAYGQTPL--MLAIMNGHVDCVHLLLEKGSTADAADLRGRTALH-----RGAvtgCEDCLAALLDHDAFV 686
Cdd:PHA03095 107 G--ADVNAK-DKVGRTPLhvYLSGFNINPKVIRLLLRKGADVNALDLYGMTPLAvllksRNA---NVELLRLLIDAGADV 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 687 LCRDFKGRTP--IHLASACGHTAVLRTLLqaALSTDPldAGVDYSGYSPMHwaSYTGHEDCLELLLehSPFsylegnpft 764
Cdd:PHA03095 181 YAVDDRFRSLlhHHLQSFKPRARIVRELI--RAGCDP--AATDMLGNTPLH--SMATGSSCKRSLV--LPL--------- 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 765 plhcaVINNQDsttemllgalgakiVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTA 844
Cdd:PHA03095 244 -----LIAGIS--------------INARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGR 304
|
..
gi 767973872 845 AV 846
Cdd:PHA03095 305 AV 306
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
472-669 |
6.28e-17 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 84.27 E-value: 6.28e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 472 LEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLleMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTL--AETLVN 549
Cdd:PHA02875 18 ARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLL--MKHGAIPDVKYPDIESELHDAVEEGDVKAVEELldLGKFAD 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 550 lDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRkWTPLHAAAASGHTDSLHLLIDsgERAdITDVMDAYGQT 629
Cdd:PHA02875 96 -DVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDK-FSPLHLAVMMGDIKGIELLID--HKA-CLDIEDCCGCT 170
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 767973872 630 PLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAV 669
Cdd:PHA02875 171 PLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAALCYAI 210
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
595-690 |
6.53e-17 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 76.69 E-value: 6.53e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 595 LHAAAASGHTDSLHLLIDSGERADitdVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADaaDLRGRTALHRGAVTGCED 674
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADAN---LQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL--KDNGRTALHYAARSGHLE 75
|
90
....*....|....*.
gi 767973872 675 CLAALLDHDAFVLCRD 690
Cdd:pfam12796 76 IVKLLLEKGADINVKD 91
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
149-241 |
2.04e-16 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 75.15 E-value: 2.04e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 149 LHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNaGANVNqPNDKGFTPLHVAAVSTNGAlCL 228
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVN-LKDNGRTALHYAARSGHLE-IV 77
|
90
....*....|...
gi 767973872 229 ELLVNNGADVNYQ 241
Cdd:pfam12796 78 KLLLEKGADINVK 90
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
1-171 |
2.34e-16 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 83.96 E-value: 2.34e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 1 MSGANVNAKDTLWLTPLHRAAA-SRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSG 79
Cdd:PHA02876 329 MLGADVNAADRLYITPLHQASTlDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKI 408
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 80 RSALHHAVH-SGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLG-HLEVLKLLVARGADLGCKD-RKGYGLLhtaAASG 156
Cdd:PHA02876 409 GTALHFALCgTNPYMSVKTLIDRGANVNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINiQNQYPLL---IALE 485
|
170
....*....|....*
gi 767973872 157 QIEVVKYLLRMGAEI 171
Cdd:PHA02876 486 YHGIVNILLHYGAEL 500
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
801-894 |
5.35e-16 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 74.00 E-value: 5.35e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 801 LHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADltvLDENKNTALHLACSKGHEKCA 880
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVN---LKDNGRTALHYAARSGHLEIV 77
|
90
....*....|....
gi 767973872 881 LMILAETQDLGLIN 894
Cdd:pfam12796 78 KLLLEKGADINVKD 91
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
186-502 |
9.28e-16 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 80.78 E-value: 9.28e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 186 CYLGQDAVAIE--LVNAGANVNQPNDKGFTPLhVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQI 263
Cdd:PHA02874 8 CIYSGDIEAIEkiIKNKGNCINISVDETTTPL-IDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 264 LIQNGSE-----IDCADKfgntplhvaarygheLLISTLMTNGADTARRGIHDMFPLHLAVlfgfsdccrkllSSGQLYS 338
Cdd:PHA02874 87 LIDNGVDtsilpIPCIEK---------------DMIKTILDCGIDVNIKDAELKTFLHYAI------------KKGDLES 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 339 IvsslsnEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAG 418
Cdd:PHA02874 140 I------KMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHG 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 419 AGVNEADCKGCSPLHYAAASDtyRRAEP-----HTPSSHDAEEDEPLKESRRkeaFFC----LEFLLDNGADPSLRDRQG 489
Cdd:PHA02874 214 NHIMNKCKNGFTPLHNAIIHN--RSAIEllinnASINDQDIDGSTPLHHAIN---PPCdidiIDILLYHKADISIKDNKG 288
|
330
....*....|...
gi 767973872 490 YTAVHYAAAYGNR 502
Cdd:PHA02874 289 ENPIDTAFKYINK 301
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
17-107 |
1.18e-15 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 73.23 E-value: 1.18e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 17 LHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADrsGRSALHHAVHSGHLETVN 96
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDN--GRTALHYAARSGHLEIVK 78
|
90
....*....|.
gi 767973872 97 LLLNKGASLNV 107
Cdd:pfam12796 79 LLLEKGADINV 89
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
679-932 |
1.26e-15 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 81.65 E-value: 1.26e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 679 LLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQ--AALSTDPLDagvdysGYSPMHWASYTGHEDCLELLLEHSpfS 756
Cdd:PHA02876 164 LLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSygADVNIIALD------DLSVLECAVDSKNIDTIKAIIDNR--S 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 757 YLEGNPFTPLHcaVINNQDSTTEMLLGALGAKiVNSRDAKGRTPLHAAAFADNVSGL-RMLLQHQAEVNATDHTGRTALM 835
Cdd:PHA02876 236 NINKNDLSLLK--AIRNEDLETSLLLYDAGFS-VNSIDDCKNTPLHHASQAPSLSRLvPKLLERGADVNAKNIKGETPLY 312
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 836 TAAENG-QTAAVEFLLYRGkADLTVLDENKNTALHLACSKGHEKCALMILAEtqdLGL-INATNSALQMPLHIAARNGLA 913
Cdd:PHA02876 313 LMAKNGyDTENIRTLIMLG-ADVNAADRLYITPLHQASTLDRNKDIVITLLE---LGAnVNARDYCDKTPIHYAAVRNNV 388
|
250
....*....|....*....
gi 767973872 914 SVVQALLSHGATVLAVDEE 932
Cdd:PHA02876 389 VIINTLLDYGADIEALSQK 407
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
561-657 |
1.50e-15 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 72.84 E-value: 1.50e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 561 LFLATERGSTECVEVLTAHGASALIKErKRKWTPLHAAAASGHTDSLHLLIDSGeRADITDvmdaYGQTPLMLAIMNGHV 640
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQD-KNGRTALHLAAKNGHLEIVKLLLEHA-DVNLKD----NGRTALHYAARSGHL 74
|
90
....*....|....*..
gi 767973872 641 DCVHLLLEKGSTADAAD 657
Cdd:pfam12796 75 EIVKLLLEKGADINVKD 91
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
3-137 |
1.83e-15 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 79.71 E-value: 1.83e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 3 GANVNAKDTLWLTPLHRAAA--SRNEKVLGLLLAHSADVNARDKLWQTPLHVA----------------------AANRA 58
Cdd:PHA03100 96 GANVNAPDNNGITPLLYAISkkSNSYSIVEYLLDNGANVNIKNSDGENLLHLYlesnkidlkilkllidkgvdinAKNRV 175
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767973872 59 tkcaEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGAD 137
Cdd:PHA03100 176 ----NYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPS 250
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
834-930 |
7.86e-15 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 70.92 E-value: 7.86e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 834 LMTAAENGQTAAVEFLLYRGkADLTVLDENKNTALHLACSKGHEKCAlMILAETQDLGLINATNSalqmPLHIAARNGLA 913
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENG-ADANLQDKNGRTALHLAAKNGHLEIV-KLLLEHADVNLKDNGRT----ALHYAARSGHL 74
|
90
....*....|....*..
gi 767973872 914 SVVQALLSHGATVLAVD 930
Cdd:pfam12796 75 EIVKLLLEKGADINVKD 91
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
336-657 |
8.06e-15 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 77.78 E-value: 8.06e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 336 LYSIVS-------SLSNEHVLSAGFDINTPDNLGRT-CLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGS 407
Cdd:PHA03100 1 LYSYIVltksriiKVKNIKYIIMEDDLNDYSYKKPVlPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 408 YQCAVT-----LVTAGAGVNEADCKGCSPLHYAAasdtyrraephtpsshdaeedeplkeSRRKEAFFCLEFLLDNGADP 482
Cdd:PHA03100 81 NLTDVKeivklLLEYGANVNAPDNNGITPLLYAI--------------------------SKKSNSYSIVEYLLDNGANV 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 483 SLRDRQGYTAVHYAAAYgNRQNLELllemsfncledvestipvsplhlaaynghceaLKTLAETLVNLDVRDHkgrtalf 562
Cdd:PHA03100 135 NIKNSDGENLLHLYLES-NKIDLKI--------------------------------LKLLIDKGVDINAKNR------- 174
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 563 latergstecVEVLTAHGASALIKErKRKWTPLHAAAASGHTDSLHLLIDSGerADITDVMDaYGQTPLMLAIMNGHVDC 642
Cdd:PHA03100 175 ----------VNYLLSYGVPINIKD-VYGFTPLHYAVYNNNPEFVKYLLDLG--ANPNLVNK-YGDTPLHIAILNNNKEI 240
|
330
....*....|....*
gi 767973872 643 VHLLLEKGSTADAAD 657
Cdd:PHA03100 241 FKLLLNNGPSIKTII 255
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
315-425 |
1.14e-14 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 70.14 E-value: 1.14e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 315 LHLAVLFGFSDCCRKLLSSGqlysivsslsnehvlsagFDINTPDNLGRTCLHAAASGGNVECLNLLLSSgADLRRRDKf 394
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENG------------------ADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDN- 60
|
90 100 110
....*....|....*....|....*....|.
gi 767973872 395 GRTPLHYAAANGSYQCAVTLVTAGAGVNEAD 425
Cdd:pfam12796 61 GRTALHYAARSGHLEIVKLLLEKGADINVKD 91
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
366-486 |
1.66e-14 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 69.76 E-value: 1.66e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 366 LHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGvnEADCKGCSPLHYAAasdtyrrae 445
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV--NLKDNGRTALHYAA--------- 69
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 767973872 446 phtpsshdaeedeplkESRRKEaffCLEFLLDNGADPSLRD 486
Cdd:pfam12796 70 ----------------RSGHLE---IVKLLLEKGADINVKD 91
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
631-714 |
1.66e-14 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 69.76 E-value: 1.66e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 631 LMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHdaFVLCRDFKGRTPIHLASACGHTAVLR 710
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH--ADVNLKDNGRTALHYAARSGHLEIVK 78
|
....
gi 767973872 711 TLLQ 714
Cdd:pfam12796 79 LLLE 82
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
13-223 |
3.99e-14 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 76.59 E-value: 3.99e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 13 WLTPLHRAAASRN-EKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEAL---APLLssLNVADRS----GRSALH 84
Cdd:cd22192 17 SESPLLLAAKENDvQAIKKLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLmeaAPEL--VNEPMTSdlyqGETALH 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 85 HAVHSGHLETVNLLLNKGASL---------------NVCDKKErQPLHWAAFLGHLEVLKLLVARGADLGCKDRkgygll 149
Cdd:cd22192 95 IAVVNQNLNLVRELIARGADVvspratgtffrpgpkNLIYYGE-HPLSFAACVGNEEIVRLLIEHGADIRAQDS------ 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 150 htaaasgqievvkyllrmgaeidepnaFGNTALHI---------ACYL---------GQDAVAIELVnaganvnqPNDKG 211
Cdd:cd22192 168 ---------------------------LGNTVLHIlvlqpnktfACQMydlilsydkEDDLQPLDLV--------PNNQG 212
|
250
....*....|..
gi 767973872 212 FTPLHVAAVSTN 223
Cdd:cd22192 213 LTPFKLAAKEGN 224
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
535-811 |
1.13e-13 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 74.26 E-value: 1.13e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 535 GHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKwTPLHAAAASGHTDSLHLLIDSG 614
Cdd:PHA02875 13 GELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIE-SELHDAVEEGDVKAVEELLDLG 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 615 ERADitDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGR 694
Cdd:PHA02875 92 KFAD--DVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGC 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 695 TPIHLASACGHTAVLRTLLQAAlstdpldAGVDYSGYSP----MHWASYTGHEDCLELLLEHSP----FSYLEGNPFTPL 766
Cdd:PHA02875 170 TPLIIAMAKGDIAICKMLLDSG-------ANIDYFGKNGcvaaLCYAIENNKIDIVRLFIKRGAdcniMFMIEGEECTIL 242
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 767973872 767 HcaVINNQDSTTEM-LLGALGAKIVNSRDAKgrTPLHAAAFADNVS 811
Cdd:PHA02875 243 D--MICNMCTNLESeAIDALIADIAIRIHKK--TIRRDEGFKNNMS 284
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
80-347 |
1.75e-13 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 73.49 E-value: 1.75e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 80 RSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIE 159
Cdd:PHA02875 3 QVALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVK 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 160 VVKYLLRMGAEIDEpnafgntalhiACYlgqdavaielvnaganvnqpnDKGFTPLHVAAVSTNGALcLELLVNNGADVN 239
Cdd:PHA02875 83 AVEELLDLGKFADD-----------VFY---------------------KDGMTPLHLATILKKLDI-MKLLIARGADPD 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 240 YQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADT---ARRGihDMFPLH 316
Cdd:PHA02875 130 IPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIdyfGKNG--CVAALC 207
|
250 260 270
....*....|....*....|....*....|.
gi 767973872 317 LAVLFGFSDCCRKLLSSGQLYSIVSSLSNEH 347
Cdd:PHA02875 208 YAIENNKIDIVRLFIKRGADCNIMFMIEGEE 238
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
2-205 |
3.51e-13 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 72.72 E-value: 3.51e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 2 SGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLN-VADRSGR 80
Cdd:PHA02875 24 IGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADdVFYKDGM 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 81 SALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEV 160
Cdd:PHA02875 104 TPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAI 183
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 767973872 161 VKYLLRMGAEIDEPNAFGNTALhiACYLGQ----DAVAIeLVNAGANVN 205
Cdd:PHA02875 184 CKMLLDSGANIDYFGKNGCVAA--LCYAIEnnkiDIVRL-FIKRGADCN 229
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
380-700 |
7.71e-13 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 72.79 E-value: 7.71e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 380 LLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRraephtpsshdaeedep 459
Cdd:PHA02876 163 MLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNID----------------- 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 460 lkesrrkeaffCLEFLLDNGADPSLRDRQGYTAVhyaaaygNRQNLE--LLLE---MSFNCLEDVESTipvsPLHLAAYN 534
Cdd:PHA02876 226 -----------TIKAIIDNRSNINKNDLSLLKAI-------RNEDLEtsLLLYdagFSVNSIDDCKNT----PLHHASQA 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 535 GHCEAL-KTLAETLVNLDVRDHKGRTALFLATERG-STECVEVLTAHGASALIKERKRKwTPLHAAAA-SGHTDSLHLLI 611
Cdd:PHA02876 284 PSLSRLvPKLLERGADVNAKNIKGETPLYLMAKNGyDTENIRTLIMLGADVNAADRLYI-TPLHQASTlDRNKDIVITLL 362
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 612 DSGERadiTDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRgAVTGCEDCLA--ALLDHDAFVLCR 689
Cdd:PHA02876 363 ELGAN---VNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHF-ALCGTNPYMSvkTLIDRGANVNSK 438
|
330
....*....|.
gi 767973872 690 DFKGRTPIHLA 700
Cdd:PHA02876 439 NKDLSTPLHYA 449
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
148-284 |
8.29e-13 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 72.35 E-value: 8.29e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 148 LLHTAAASGQIEVVKYLLRM-GAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGAN-VNQPND----KGFTPLHVAAVS 221
Cdd:cd22192 20 PLLLAAKENDVQAIKKLLKCpSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPElVNEPMTsdlyQGETALHIAVVN 99
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767973872 222 TNGALcLELLVNNGADVN-------YQSKEGKS-------PLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHV 284
Cdd:cd22192 100 QNLNL-VRELIARGADVVspratgtFFRPGPKNliyygehPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHI 175
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
472-728 |
8.50e-13 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 71.62 E-value: 8.50e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 472 LEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNclEDVESTIPVSPLHLAAYNGHC-----EALKTLAET 546
Cdd:PHA03100 18 IKYIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGAD--INSSTKNNSTPLHYLSNIKYNltdvkEIVKLLLEY 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 547 LVNLDVRDHKGRTALFLA--TERGSTECVEVLTAHGASALIKeRKRKWTPLHAAAASGHTDS--LHLLIDSGerADItDV 622
Cdd:PHA03100 96 GANVNAPDNNGITPLLYAisKKSNSYSIVEYLLDNGANVNIK-NSDGENLLHLYLESNKIDLkiLKLLIDKG--VDI-NA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 623 MDAygqtplmlaimnghvdcVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASA 702
Cdd:PHA03100 172 KNR-----------------VNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAIL 234
|
250 260
....*....|....*....|....*.
gi 767973872 703 CGHTAVLRTLLQAALSTDPLDAGVDY 728
Cdd:PHA03100 235 NNNKEIFKLLLNNGPSIKTIIETLLY 260
|
|
| trp |
TIGR00870 |
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ... |
5-223 |
1.11e-12 |
|
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273311 [Multi-domain] Cd Length: 743 Bit Score: 72.04 E-value: 1.11e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 5 NVNAKDTLWLTPLHRAAA-SRNEKVLGLLLAHSADVNARDKLwqtpLHVAAANRATKCAEALAPLL-------SSLNVAD 76
Cdd:TIGR00870 44 NINCPDRLGRSALFVAAIeNENLELTELLLNLSCRGAVGDTL----LHAISLEYVDAVEAILLHLLaafrksgPLELAND 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 77 RS------GRSALHHAVHSGHLETVNLLLNKGASLNV------CDKKERQ--------PLHWAAFLGHLEVLKLLVARGA 136
Cdd:TIGR00870 120 QYtseftpGITALHLAAHRQNYEIVKLLLERGASVPAracgdfFVKSQGVdsfyhgesPLNAAACLGSPSIVALLSEDPA 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 137 DLGCKDRKGYGLLHtaaasgqievvkyLLRMGAEidepNAFGNTALHIACY------LGQ--DAVAIELVnaganvnqPN 208
Cdd:TIGR00870 200 DILTADSLGNTLLH-------------LLVMENE----FKAEYEELSCQMYnfalslLDKlrDSKELEVI--------LN 254
|
250
....*....|....*
gi 767973872 209 DKGFTPLHVAAVSTN 223
Cdd:TIGR00870 255 HQGLTPLKLAAKEGR 269
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
172-416 |
1.29e-12 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 71.45 E-value: 1.29e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 172 DEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTN---------------------------- 223
Cdd:PHA02878 31 TSASLIPFIPLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNklgmkemirsinkcsvfytlvaikdafn 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 224 -----------------------------------GALCLELLVNNGADVNYQSKE-GKSPLHMAAIHGRFTRSQILIQN 267
Cdd:PHA02878 111 nrnveifkiiltnrykniqtidlvyidkkskddiiEAEITKLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSY 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 268 GSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVlfgfsdccrkllSSGQLYSIVSSLsneh 347
Cdd:PHA02878 191 GANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISV------------GYCKDYDILKLL---- 254
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767973872 348 vLSAGFDINTPDN-LGRTCLHAAASGGNVecLNLLLSSGADLRRRDKFGRTPLHYAAANGS-YQCAVTLVT 416
Cdd:PHA02878 255 -LEHGVDVNAKSYiLGLTALHSSIKSERK--LKLLLEYGADINSLNSYKLTPLSSAVKQYLcINIGRILIS 322
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
475-700 |
1.38e-12 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 71.15 E-value: 1.38e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 475 LLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNC-LEDVESTIPVsplHLAAYNGHCEALKTLAETLVNLDVR 553
Cdd:PHA02874 110 ILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVnIEDDNGCYPI---HIAIKHNFFDIIKLLLEKGAYANVK 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 554 DHKGRTALFLATERGSTECVEVLTAHGASALIKeRKRKWTPLHAAAasghtdslhllidsgeraditdvmdAYGQTPLML 633
Cdd:PHA02874 187 DNNGESPLHNAAEYGDYACIKLLIDHGNHIMNK-CKNGFTPLHNAI-------------------------IHNRSAIEL 240
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767973872 634 AIMNghvdcvhlllekgSTADAADLRGRTALHRGAVTGCE-DCLAALLDHDAFVLCRDFKGRTPIHLA 700
Cdd:PHA02874 241 LINN-------------ASINDQDIDGSTPLHHAINPPCDiDIIDILLYHKADISIKDNKGENPIDTA 295
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
282-392 |
1.55e-12 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 64.37 E-value: 1.55e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 282 LHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSgqlysivsslsnehvlsagFDINTPDNl 361
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-------------------ADVNLKDN- 60
|
90 100 110
....*....|....*....|....*....|.
gi 767973872 362 GRTCLHAAASGGNVECLNLLLSSGADLRRRD 392
Cdd:pfam12796 61 GRTALHYAARSGHLEIVKLLLEKGADINVKD 91
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
249-334 |
1.65e-12 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 64.37 E-value: 1.65e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 249 LHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGAdtARRGIHDMFPLHLAVLFGFSDCCR 328
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD--VNLKDNGRTALHYAARSGHLEIVK 78
|
....*.
gi 767973872 329 KLLSSG 334
Cdd:pfam12796 79 LLLEKG 84
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
215-303 |
1.97e-12 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 63.98 E-value: 1.97e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 215 LHVAAVStNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGsEIDCADKfGNTPLHVAARYGHELLI 294
Cdd:pfam12796 1 LHLAAKN-GNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHA-DVNLKDN-GRTALHYAARSGHLEIV 77
|
....*....
gi 767973872 295 STLMTNGAD 303
Cdd:pfam12796 78 KLLLEKGAD 86
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
204-510 |
2.11e-12 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 70.46 E-value: 2.11e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 204 VNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAA-IHGRFTR----SQILIQNGSEIDCADKFG 278
Cdd:PHA03100 27 LNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSnIKYNLTDvkeiVKLLLEYGANVNAPDNNG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 279 NTPLHVAA--RYGHELLISTLMTNGADT---ARRGIHdmfPLHLAVlfgfSDCCRKLlssgqlySIVSSLsnehvLSAGF 353
Cdd:PHA03100 107 ITPLLYAIskKSNSYSIVEYLLDNGANVnikNSDGEN---LLHLYL----ESNKIDL-------KILKLL-----IDKGV 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 354 DINTPDNLgrtclhaaasggnveclNLLLSSGADlrrrdkfgrtplhyaaangsyqcavtlvtagagVNEADCKGCSPLH 433
Cdd:PHA03100 168 DINAKNRV-----------------NYLLSYGVP---------------------------------INIKDVYGFTPLH 197
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767973872 434 YAAasdtyrraephtpsSHDAEEdeplkesrrkeaFFclEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLE 510
Cdd:PHA03100 198 YAV--------------YNNNPE------------FV--KYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLN 246
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
494-586 |
2.64e-12 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 63.60 E-value: 2.64e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 494 HYAAAYGNRQNLELLLEMSFNCleDVESTIPVSPLHLAAYNGHCEALKTLAETlVNLDVRDHkGRTALFLATERGSTECV 573
Cdd:pfam12796 2 HLAAKNGNLELVKLLLENGADA--NLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDN-GRTALHYAARSGHLEIV 77
|
90
....*....|...
gi 767973872 574 EVLTAHGASALIK 586
Cdd:pfam12796 78 KLLLEKGADINVK 90
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
398-700 |
3.50e-12 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 69.91 E-value: 3.50e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 398 PLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAAsdtyrraEPHTPSshdaeedepLKESRRKEaffcleflld 477
Cdd:PHA02878 40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICK-------EPNKLG---------MKEMIRSI---------- 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 478 ngadpsLRDRQGYTAVHYAAAYGNRqNLELLLEMSFNCLeDVESTIPVSPLHLAAYNGHCEA--LKTLAETLVNLDVRD- 554
Cdd:PHA02878 94 ------NKCSVFYTLVAIKDAFNNR-NVEIFKIILTNRY-KNIQTIDLVYIDKKSKDDIIEAeiTKLLLSYGADINMKDr 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 555 HKGRTALFLATERGSTECVEVLTAHGASALIKERKRKwTPLHAAAASGHTDSLHLLIDSGERadiTDVMDAYGQTPLMLA 634
Cdd:PHA02878 166 HKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNN-SPLHHAVKHYNKPIVHILLENGAS---TDARDKCGNTPLHIS 241
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 635 ImnGHV---DCVHLLLEKGSTADA-ADLRGRTALHRGAVTgcEDCLAALLDHDAFVLCRDFKGRTPIHLA 700
Cdd:PHA02878 242 V--GYCkdyDILKLLLEHGVDVNAkSYILGLTALHSSIKS--ERKLKLLLEYGADINSLNSYKLTPLSSA 307
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
281-531 |
3.96e-12 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 69.91 E-value: 3.96e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 281 PLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAV----LFGFSDCCRKLLS---SGQLYSIVSSLSNEHV----- 348
Cdd:PHA02878 40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICkepnKLGMKEMIRSINKcsvFYTLVAIKDAFNNRNVeifki 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 349 -LSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDK-FGRTPLHYAAANGSYQCAVTLVTAGAGVNEADC 426
Cdd:PHA02878 120 iLTNRYKNIQTIDLVYIDKKSKDDIIEAEITKLLLSYGADINMKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDK 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 427 KGCSPLHYAaasdtyrraephtpsshdaeedepLKESRRKeaffCLEFLLDNGADPSLRDRQGYTAVHYAAAY-GNRQNL 505
Cdd:PHA02878 200 TNNSPLHHA------------------------VKHYNKP----IVHILLENGASTDARDKCGNTPLHISVGYcKDYDIL 251
|
250 260
....*....|....*....|....*..
gi 767973872 506 ELLLEMSFNCleDVESTI-PVSPLHLA 531
Cdd:PHA02878 252 KLLLEHGVDV--NAKSYIlGLTALHSS 276
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
20-175 |
5.76e-12 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 69.90 E-value: 5.76e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 20 AAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLL 99
Cdd:PLN03192 532 VASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILY 611
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767973872 100 NKGASLNvcDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPN 175
Cdd:PLN03192 612 HFASISD--PHAAGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKAN 685
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
734-827 |
9.56e-12 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 62.06 E-value: 9.56e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 734 MHWASYTGHEDCLELLLE-HSPFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNsrdaKGRTPLHAAAFADNVSG 812
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLEnGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKD----NGRTALHYAARSGHLEI 76
|
90
....*....|....*
gi 767973872 813 LRMLLQHQAEVNATD 827
Cdd:pfam12796 77 VKLLLEKGADINVKD 91
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
185-429 |
1.26e-11 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 67.71 E-value: 1.26e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 185 ACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAaVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQIL 264
Cdd:PHA02875 9 AILFGELDIARRLLDIGINPNFEIYDGISPIKLA-MKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEEL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 265 IQNGSEI-DCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGfsdccrkllssgqlysivssl 343
Cdd:PHA02875 88 LDLGKFAdDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMG--------------------- 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 344 snehvlsagfDINTpdnlgrtclhaaasggnvecLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNE 423
Cdd:PHA02875 147 ----------DIKG--------------------IELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDY 196
|
....*.
gi 767973872 424 ADCKGC 429
Cdd:PHA02875 197 FGKNGC 202
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
609-858 |
1.35e-11 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 68.74 E-value: 1.35e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 609 LLIDSGERaDITDVMDAygqtPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLC 688
Cdd:PLN03192 512 LLGDNGGE-HDDPNMAS----NLLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHI 586
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 689 RDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGvdysgyspmhwasytghedclELLLEhspfsylegnpftplhc 768
Cdd:PLN03192 587 RDANGNTALWNAISAKHHKIFRILYHFASISDPHAAG---------------------DLLCT----------------- 628
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 769 avinnqdsttemllgalgakivnsrdakgrtplhaAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEF 848
Cdd:PLN03192 629 -----------------------------------AAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRL 673
|
250
....*....|
gi 767973872 849 LLYRGkADLT 858
Cdd:PLN03192 674 LIMNG-ADVD 682
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
471-554 |
2.74e-11 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 60.90 E-value: 2.74e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 471 CLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTipvsPLHLAAYNGHCEALKTLAETLVNL 550
Cdd:pfam12796 12 LVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDNGRT----ALHYAARSGHLEIVKLLLEKGADI 87
|
....
gi 767973872 551 DVRD 554
Cdd:pfam12796 88 NVKD 91
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
52-215 |
4.54e-11 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 67.20 E-value: 4.54e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 52 VAAANRATKCAEALAPLLSSL-------NVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGH 124
Cdd:PLN03192 524 NMASNLLTVASTGNAALLEELlkakldpDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKH 603
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 125 LEVLKLL--VARGADlgckDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGA 202
Cdd:PLN03192 604 HKIFRILyhFASISD----PHAAGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGA 679
|
170
....*....|....
gi 767973872 203 NVNQPN-DKGFTPL 215
Cdd:PLN03192 680 DVDKANtDDDFSPT 693
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
362-415 |
6.78e-11 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 58.44 E-value: 6.78e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 767973872 362 GRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLV 415
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
213-400 |
9.49e-11 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 65.80 E-value: 9.49e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 213 TPLHVAAvSTNGALCLE-LLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSE-----IDCADKFGNTPLHVAA 286
Cdd:cd22192 19 SPLLLAA-KENDVQAIKkLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPElvnepMTSDLYQGETALHIAV 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 287 RYGHELLISTLMTNGADTA---------RRGIHDMFplhlavLFGfsdccrkllssgqlysivsslsnEHVLSagFdint 357
Cdd:cd22192 98 VNQNLNLVRELIARGADVVspratgtffRPGPKNLI------YYG-----------------------EHPLS--F---- 142
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 767973872 358 pdnlgrtclhaAASGGNVECLNLLLSSGADLRRRDKFGRTPLH 400
Cdd:cd22192 143 -----------AACVGNEEIVRLLIEHGADIRAQDSLGNTVLH 174
|
|
| PHA02946 |
PHA02946 |
ankyin-like protein; Provisional |
196-399 |
1.01e-10 |
|
ankyin-like protein; Provisional
Pssm-ID: 165256 [Multi-domain] Cd Length: 446 Bit Score: 65.08 E-value: 1.01e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 196 ELVNAGANVNQPNDKGFTPLHVAAVSTNGALcLELLVNNGADVNYQSKEGKSPLHMAAIHGR--FTRSQILIQNGSEID- 272
Cdd:PHA02946 57 ELLHRGYSPNETDDDGNYPLHIASKINNNRI-VAMLLTHGADPNACDKQHKTPLYYLSGTDDevIERINLLVQYGAKINn 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 273 CADKFGNTPLhVAARYGHELLISTLMTNGadtarrgihdmFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLsnehvLSAG 352
Cdd:PHA02946 136 SVDEEGCGPL-LACTDPSERVFKKIMSIG-----------FEARIVDKFGKNHIHRHLMSDNPKASTISWM-----MKLG 198
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 767973872 353 FDINTPDNLGRTCLHAAASG--GNVECLNLLLSSgADLRRRDKFGRTPL 399
Cdd:PHA02946 199 ISPSKPDHDGNTPLHIVCSKtvKNVDIINLLLPS-TDVNKQNKFGDSPL 246
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
79-132 |
2.26e-10 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 56.90 E-value: 2.26e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 767973872 79 GRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLV 132
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
598-873 |
3.10e-10 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 63.47 E-value: 3.10e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 598 AAASGHTDSLHLLIDSGERADITdVMDAYgqTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLA 677
Cdd:PHA02875 9 AILFGELDIARRLLDIGINPNFE-IYDGI--SPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVE 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 678 ALLDHDAF---VLCRDfkGRTPIHLASACGHTAVLRTLLqaALSTDPLDAGVDYsgYSPMHWASYTGHEDCLELLLEHSP 754
Cdd:PHA02875 86 ELLDLGKFaddVFYKD--GMTPLHLATILKKLDIMKLLI--ARGADPDIPNTDK--FSPLHLAVMMGDIKGIELLIDHKA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 755 FSYLEgnpftplhcavinnqdsttemllgalgakivnsrDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTAL 834
Cdd:PHA02875 160 CLDIE----------------------------------DCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAA 205
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 767973872 835 M-TAAENGQTAAVEFLLYRGkAD---LTVLDENKNTALHLACS 873
Cdd:PHA02875 206 LcYAIENNKIDIVRLFIKRG-ADcniMFMIEGEECTILDMICN 247
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
790-950 |
6.18e-10 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 62.67 E-value: 6.18e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 790 VNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGkADLTVLDENKNTALH 869
Cdd:PHA02874 117 VNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKG-AYANVKDNNGESPLH 195
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 870 LACSKGHEKCALMILAETQDlgLINATNSALqMPLHIAARNGLASVvqALLSHGATVLAVDEEGHTP---ALACAPNKDV 946
Cdd:PHA02874 196 NAAEYGDYACIKLLIDHGNH--IMNKCKNGF-TPLHNAIIHNRSAI--ELLINNASINDQDIDGSTPlhhAINPPCDIDI 270
|
....
gi 767973872 947 ADCL 950
Cdd:PHA02874 271 IDIL 274
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
790-946 |
9.13e-10 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 62.35 E-value: 9.13e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 790 VNSRDAKGRTPLHA---AAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAV-EFLLYRGkADLTVLDENKN 865
Cdd:PHA03095 40 VNFRGEYGKTPLHLylhYSSEKVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATTLDViKLLIKAG-ADVNAKDKVGR 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 866 TALHlACSKG---HEKCALMILAETQDlglINATNSALQMPLHIAARNGLASV--VQALLSHGATVLAVDEEG----HTP 936
Cdd:PHA03095 119 TPLH-VYLSGfniNPKVIRLLLRKGAD---VNALDLYGMTPLAVLLKSRNANVelLRLLIDAGADVYAVDDRFrsllHHH 194
|
170
....*....|
gi 767973872 937 ALACAPNKDV 946
Cdd:PHA03095 195 LQSFKPRARI 204
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
112-165 |
1.01e-09 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 54.97 E-value: 1.01e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 767973872 112 ERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLL 165
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
3-116 |
1.05e-09 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 62.20 E-value: 1.05e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 3 GANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAAnrATKCAEALAPLLS-SLNVADRS--- 78
Cdd:PHA02878 191 GANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVG--YCKDYDILKLLLEhGVDVNAKSyil 268
|
90 100 110
....*....|....*....|....*....|....*...
gi 767973872 79 GRSALHHAVHSGhlETVNLLLNKGASLNVCDKKERQPL 116
Cdd:PHA02878 269 GLTALHSSIKSE--RKLKLLLEYGADINSLNSYKLTPL 304
|
|
| PHA02946 |
PHA02946 |
ankyin-like protein; Provisional |
71-251 |
1.23e-09 |
|
ankyin-like protein; Provisional
Pssm-ID: 165256 [Multi-domain] Cd Length: 446 Bit Score: 61.61 E-value: 1.23e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 71 SLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGH--LEVLKLLVARGADLGCK-DRKGYG 147
Cdd:PHA02946 64 SPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTDDevIERINLLVQYGAKINNSvDEEGCG 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 148 LLhTAAASGQIEVVKYLLRMGAEIDEPNAFGNTalHIACYLGQD---AVAIE-LVNAGANVNQPNDKGFTPLHVAAVSTN 223
Cdd:PHA02946 144 PL-LACTDPSERVFKKIMSIGFEARIVDKFGKN--HIHRHLMSDnpkASTISwMMKLGISPSKPDHDGNTPLHIVCSKTV 220
|
170 180
....*....|....*....|....*...
gi 767973872 224 GALCLELLVNNGADVNYQSKEGKSPLHM 251
Cdd:PHA02946 221 KNVDIINLLLPSTDVNKQNKFGDSPLTL 248
|
|
| PHA02798 |
PHA02798 |
ankyrin-like protein; Provisional |
17-285 |
2.00e-09 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222931 [Multi-domain] Cd Length: 489 Bit Score: 61.39 E-value: 2.00e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 17 LHRAAASRneKVLGLLLAHSADVNARDKLWQTPLhvaaanratkCAealapLLSslNVADrsgrsalhhavHSGHLETVN 96
Cdd:PHA02798 44 LQRDSPST--DIVKLFINLGANVNGLDNEYSTPL----------CT-----ILS--NIKD-----------YKHMLDIVK 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 97 LLLNKGASLNVCDKKERQPLHWA---AFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASG---QIEVVKYLLRMGAE 170
Cdd:PHA02798 94 ILIENGADINKKNSDGETPLYCLlsnGYINNLEILLFMIENGADTTLLDKDGFTMLQVYLQSNhhiDIEIIKLLLEKGVD 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 171 IDE-PNAFGNTALHiaCYLGQDAVAIE------LVNAGANVNQPND---KGFTPLHVAAVSTNGALCLELL--VNNGADV 238
Cdd:PHA02798 174 INThNNKEKYDTLH--CYFKYNIDRIDadilklFVDNGFIINKENKshkKKFMEYLNSLLYDNKRFKKNILdfIFSYIDI 251
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 767973872 239 NYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVA 285
Cdd:PHA02798 252 NQVDELGFNPLYYSVSHNNRKIFEYLLQLGGDINIITELGNTCLFTA 298
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
592-647 |
3.20e-09 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 53.43 E-value: 3.20e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 767973872 592 WTPLHAAAASGHTDSLHLLIDSGerADItDVMDAYGQTPLMLAIMNGHVDCVHLLL 647
Cdd:pfam13637 2 LTALHAAAASGHLELLRLLLEKG--ADI-NAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
797-959 |
3.91e-09 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 60.00 E-value: 3.91e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 797 GRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGH 876
Cdd:PHA02875 35 GISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLATILKK 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 877 EKCALMILAETQDLGLINATNSAlqmPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALILST 956
Cdd:PHA02875 115 LDIMKLLIARGADPDIPNTDKFS---PLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSG 191
|
...
gi 767973872 957 MKP 959
Cdd:PHA02875 192 ANI 194
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
278-515 |
6.27e-09 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 59.23 E-value: 6.27e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 278 GNTPLHVAARYGHELLISTLMTNGA--DTARRGIHDmfPLHLAVLFGFSDCCRKLLSSGqlysivsSLSNEHVLSAGfdi 355
Cdd:PHA02875 35 GISPIKLAMKFRDSEAIKLLMKHGAipDVKYPDIES--ELHDAVEEGDVKAVEELLDLG-------KFADDVFYKDG--- 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 356 NTPdnlgrtcLHAAASGGNVECLNLLLSSGAD--LRRRDKFgrTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLH 433
Cdd:PHA02875 103 MTP-------LHLATILKKLDIMKLLIARGADpdIPNTDKF--SPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLI 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 434 YAAAsdtyrraephtpsshdaeedeplkesrRKEAFFClEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNL-ELLLEMS 512
Cdd:PHA02875 174 IAMA---------------------------KGDIAIC-KMLLDSGANIDYFGKNGCVAALCYAIENNKIDIvRLFIKRG 225
|
...
gi 767973872 513 FNC 515
Cdd:PHA02875 226 ADC 228
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
517-658 |
6.65e-09 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 59.88 E-value: 6.65e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 517 EDVESTIPVSPLHLAAyNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKE--------- 587
Cdd:PLN03192 519 EHDDPNMASNLLTVAS-TGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDangntalwn 597
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 588 ------RKRKWTPLHAAAASGHTDSLHLLIDSGERADIT------------DVMDAYGQTPLMLAIMNGHVDCVHLLLEK 649
Cdd:PLN03192 598 aisakhHKIFRILYHFASISDPHAAGDLLCTAAKRNDLTamkellkqglnvDSEDHQGATALQVAMAEDHVDMVRLLIMN 677
|
....*....
gi 767973872 650 GSTADAADL 658
Cdd:PLN03192 678 GADVDKANT 686
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
368-509 |
6.77e-09 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 59.88 E-value: 6.77e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 368 AAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPL--------------- 432
Cdd:PLN03192 531 TVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALwnaisakhhkifril 610
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767973872 433 -HYAAASDtyrraePHTPSshdaeedEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLL 509
Cdd:PLN03192 611 yHFASISD------PHAAG-------DLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLI 675
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
797-850 |
9.68e-09 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 52.28 E-value: 9.68e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 767973872 797 GRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLL 850
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
661-853 |
1.73e-08 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 58.08 E-value: 1.73e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 661 RTALHRGAVTGCEDCLAALLD---HDAFVLcrdFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDysgySPMHWA 737
Cdd:PHA02875 3 QVALCDAILFGELDIARRLLDigiNPNFEI---YDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIE----SELHDA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 738 SYTGHEDCLELLLEHSPFS----YLEGNpfTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKgrTPLHAAAFADNVSGL 813
Cdd:PHA02875 76 VEEGDVKAVEELLDLGKFAddvfYKDGM--TPLHLATILKKLDIMKLLIARGADPDIPNTDKF--SPLHLAVMMGDIKGI 151
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 767973872 814 RMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRG 853
Cdd:PHA02875 152 ELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSG 191
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
705-931 |
2.51e-08 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 57.37 E-value: 2.51e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 705 HTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHS--PFSYLEGNpFTPLH-----CAVINNQDST 777
Cdd:PHA03100 10 SRIIKVKNIKYIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGadINSSTKNN-STPLHylsniKYNLTDVKEI 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 778 TEMLLgALGAkIVNSRDAKGRTPLHAAAFA--DNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQ--TAAVEFLLYRG 853
Cdd:PHA03100 89 VKLLL-EYGA-NVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKidLKILKLLIDKG 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 854 ---------------KADLTVLDENKNTALHLACSKGHEKCALMILaetqDLGL-INATNSALQMPLHIAARNGLASVVQ 917
Cdd:PHA03100 167 vdinaknrvnyllsyGVPINIKDVYGFTPLHYAVYNNNPEFVKYLL----DLGAnPNLVNKYGDTPLHIAILNNNKEIFK 242
|
250
....*....|....
gi 767973872 918 ALLSHGATVLAVDE 931
Cdd:PHA03100 243 LLLNNGPSIKTIIE 256
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
2-107 |
2.76e-08 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 57.34 E-value: 2.76e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 2 SGANVNAKDTLWLTPLHRAAASRNEK--VLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSG 79
Cdd:PHA03095 211 AGCDPAATDMLGNTPLHSMATGSSCKrsLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDG 290
|
90 100
....*....|....*....|....*...
gi 767973872 80 RSALHHAVHSGHLETVNLLLNKGASLNV 107
Cdd:PHA03095 291 NTPLSLMVRNNNGRAVRAALAKNPSAET 318
|
|
| trp |
TIGR00870 |
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ... |
140-286 |
4.15e-08 |
|
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273311 [Multi-domain] Cd Length: 743 Bit Score: 57.40 E-value: 4.15e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 140 CKDRKGYGLLHTAAASGQ-IEVVKYLLRMGAEIDEpnafGNTALHIACYLGQDAV----AIELVNAGANVNQP--ND--- 209
Cdd:TIGR00870 47 CPDRLGRSALFVAAIENEnLELTELLLNLSCRGAV----GDTLLHAISLEYVDAVeailLHLLAAFRKSGPLElaNDqyt 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 210 ----KGFTPLHVAAVsTNGALCLELLVNNGADVNYQSK--------------EGKSPLHMAAIHGRFTRSQILIQNGSEI 271
Cdd:TIGR00870 123 seftPGITALHLAAH-RQNYEIVKLLLERGASVPARACgdffvksqgvdsfyHGESPLNAAACLGSPSIVALLSEDPADI 201
|
170
....*....|....*
gi 767973872 272 DCADKFGNTPLHVAA 286
Cdd:TIGR00870 202 LTADSLGNTLLHLLV 216
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
276-433 |
6.50e-08 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 56.56 E-value: 6.50e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 276 KFGNTPLHVAARYGHELLISTLMT-NGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSgqlysiVSSLSNEHVLSAGFd 354
Cdd:cd22192 15 RISESPLLLAAKENDVQAIKKLLKcPSCDLFQRGALGETALHVAALYDNLEAAVVLMEA------APELVNEPMTSDLY- 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 355 intpdnLGRTCLHAAASGGNVECLNLLLSSGADL----------RRRDK----FGRTPLHYAAANGSYQCAVTLVTAGAG 420
Cdd:cd22192 88 ------QGETALHIAVVNQNLNLVRELIARGADVvspratgtffRPGPKnliyYGEHPLSFAACVGNEEIVRLLIEHGAD 161
|
170
....*....|...
gi 767973872 421 VNEADCKGCSPLH 433
Cdd:cd22192 162 IRAQDSLGNTVLH 174
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
781-936 |
8.00e-08 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 56.04 E-value: 8.00e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 781 LLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGkADLTVL 860
Cdd:PHA02878 152 LLLSYGADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENG-ASTDAR 230
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767973872 861 DENKNTALHLACSKGHEKCALMILAETQdlGLINATNSALQM-PLHIAARNglASVVQALLSHGATVLAVDEEGHTP 936
Cdd:PHA02878 231 DKCGNTPLHISVGYCKDYDILKLLLEHG--VDVNAKSYILGLtALHSSIKS--ERKLKLLLEYGADINSLNSYKLTP 303
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
367-470 |
1.19e-07 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 55.67 E-value: 1.19e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 367 HAAASGGNVEcLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAE- 445
Cdd:PTZ00322 88 QLAASGDAVG-ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQl 166
|
90 100
....*....|....*....|....*..
gi 767973872 446 --PHTPSSHDAEEDEPLKESRRKEAFF 470
Cdd:PTZ00322 167 lsRHSQCHFELGANAKPDSFTGKPPSL 193
|
|
| PHA02798 |
PHA02798 |
ankyrin-like protein; Provisional |
92-387 |
1.24e-07 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222931 [Multi-domain] Cd Length: 489 Bit Score: 55.61 E-value: 1.24e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 92 LETVNLLLNKGASLNVCDKKERQPL-----HWAAFLGHLEVLKLLVARGADLGCKDRKG----YGLLHTAAASgQIEVVK 162
Cdd:PHA02798 51 TDIVKLFINLGANVNGLDNEYSTPLctilsNIKDYKHMLDIVKILIENGADINKKNSDGetplYCLLSNGYIN-NLEILL 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 163 YLLRMGAEIDEPNAFGNTALHI----ACYLGQDAVAIeLVNAGANVNQPNDK-GFTPLHV---AAVSTNGALCLELLVNN 234
Cdd:PHA02798 130 FMIENGADTTLLDKDGFTMLQVylqsNHHIDIEIIKL-LLEKGVDINTHNNKeKYDTLHCyfkYNIDRIDADILKLFVDN 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 235 GADVNYQSKegksplhmaaihgrFTRSQILiqngseidcadkfgntplhvaaryghELLISTLMTNgadtaRRGIHDMFP 314
Cdd:PHA02798 209 GFIINKENK--------------SHKKKFM--------------------------EYLNSLLYDN-----KRFKKNILD 243
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767973872 315 LhlavLFGFSDCCRK-LLSSGQLYSIVSSLSN---EHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGAD 387
Cdd:PHA02798 244 F----IFSYIDINQVdELGFNPLYYSVSHNNRkifEYLLQLGGDINIITELGNTCLFTAFENESKFIFNSILNKKPN 316
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
764-936 |
1.38e-07 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 54.97 E-value: 1.38e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 764 TPLHCAVINNQDSTTEMLLgALGAKiVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQT 843
Cdd:PHA02874 126 TFLHYAIKKGDLESIKMLF-EYGAD-VNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDY 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 844 AAVEFLLYRGkADLTVLDENKNTALHLACSKGHEKCALMILAETqdlglINATNSALQMPLHIAARNGLA-SVVQALLSH 922
Cdd:PHA02874 204 ACIKLLIDHG-NHIMNKCKNGFTPLHNAIIHNRSAIELLINNAS-----INDQDIDGSTPLHHAINPPCDiDIIDILLYH 277
|
170
....*....|....
gi 767973872 923 GATVLAVDEEGHTP 936
Cdd:PHA02874 278 KADISIKDNKGENP 291
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
808-954 |
1.43e-07 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 55.64 E-value: 1.43e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 808 DNVSGLRMLLQHQAEVNA--------------TDHTGRTALMTAAENGQTAAVEFLLyRGKADLTVLDENKNTALHLACS 873
Cdd:PLN03192 489 DNVVILKNFLQHHKELHDlnvgdllgdnggehDDPNMASNLLTVASTGNAALLEELL-KAKLDPDIGDSKGRTPLHIAAS 567
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 874 KGHEKCALMILAETQDLGLINAT-NSAL---------------------QMP------LHIAARNGLASVVQALLSHGAT 925
Cdd:PLN03192 568 KGYEDCVLVLLKHACNVHIRDANgNTALwnaisakhhkifrilyhfasiSDPhaagdlLCTAAKRNDLTAMKELLKQGLN 647
|
170 180
....*....|....*....|....*....
gi 767973872 926 VLAVDEEGHTpALACAPNKDVADCLALIL 954
Cdd:PLN03192 648 VDSEDHQGAT-ALQVAMAEDHVDMVRLLI 675
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
83-176 |
1.56e-07 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 55.29 E-value: 1.56e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 83 LHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVK 162
Cdd:PTZ00322 86 LCQLAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQ 165
|
90
....*....|....
gi 767973872 163 YLLRMGAEIDEPNA 176
Cdd:PTZ00322 166 LLSRHSQCHFELGA 179
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
13-65 |
1.69e-07 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 48.81 E-value: 1.69e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 767973872 13 WLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEAL 65
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
|
|
| PHA02716 |
PHA02716 |
CPXV016; CPX019; EVM010; Provisional |
157-410 |
1.86e-07 |
|
CPXV016; CPX019; EVM010; Provisional
Pssm-ID: 165089 [Multi-domain] Cd Length: 764 Bit Score: 55.30 E-value: 1.86e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 157 QIEVVKYLLRMG-AEID-EPNAFGNTALHiaCYLGQDAVAIE----LVNAGANVNQPNDKGFTPLHVAAVSTN-GALCLE 229
Cdd:PHA02716 154 DLDLIKYMVDVGiVNLNyVCKKTGYGILH--AYLGNMYVDIDilewLCNNGVNVNLQNNHLITPLHTYLITGNvCASVIK 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 230 LLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDcADKFGNTP--LHV---AARYGHELLISTLMTNGA-- 302
Cdd:PHA02716 232 KIIELGGDMDMKCVNGMSPIMTYIINIDNINPEITNIYIESLD-GNKVKNIPmiLHSyitLARNIDISVVYSFLQPGVkl 310
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 303 ---DTARRGIhdmfpLHLAVLfgfsdccRKLLSSgqlySIVSSLsNEHvlsaGFDINTPDNLGRTCLHAAAS-------- 371
Cdd:PHA02716 311 hykDSAGRTC-----LHQYIL-------RHNIST----DIIKLL-HEY----GNDLNEPDNIGNTVLHTYLSmlsvvnil 369
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 767973872 372 ------GGNVECLNLLLSSGADLRRRDKFGRTPLhyaaanGSYQC 410
Cdd:PHA02716 370 dpetdnDIRLDVIQCLISLGADITAVNCLGYTPL------TSYIC 408
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
2-76 |
1.94e-07 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 49.73 E-value: 1.94e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767973872 2 SGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHsADVNARDKLWqTPLHVAAANRATKCAEALAPLLSSLNVAD 76
Cdd:pfam12796 19 NGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGR-TALHYAARSGHLEIVKLLLEKGADINVKD 91
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
526-699 |
2.35e-07 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 54.63 E-value: 2.35e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 526 SPLHLAAYNGHCEALKTLAETlvnldvrdhkGRTALFlatERGstecvevltAHGASALikerkrkwtplHAAAASGHTD 605
Cdd:cd22192 19 SPLLLAAKENDVQAIKKLLKC----------PSCDLF---QRG---------ALGETAL-----------HVAALYDNLE 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 606 SLHLLIDSGERAdITDVM--DAY-GQTPLMLAIMNGHVDCVHLLLEKGstADAADLR----------------GRTALHR 666
Cdd:cd22192 66 AAVVLMEAAPEL-VNEPMtsDLYqGETALHIAVVNQNLNLVRELIARG--ADVVSPRatgtffrpgpknliyyGEHPLSF 142
|
170 180 190
....*....|....*....|....*....|...
gi 767973872 667 GAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHL 699
Cdd:cd22192 143 AACVGNEEIVRLLIEHGADIRAQDSLGNTVLHI 175
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
662-753 |
2.61e-07 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 54.52 E-value: 2.61e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 662 TALHRGAVTGCEdcLAA---------LLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQaaLSTDPldAGVDYSGYS 732
Cdd:PTZ00322 77 VVAHMLTVELCQ--LAAsgdavgariLLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLE--FGADP--TLLDKDGKT 150
|
90 100
....*....|....*....|.
gi 767973872 733 PMHWASYTGHEDCLELLLEHS 753
Cdd:PTZ00322 151 PLELAEENGFREVVQLLSRHS 171
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
597-729 |
3.12e-07 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 54.49 E-value: 3.12e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 597 AAAASGHTDSLHLLIDSGERADITDvmdAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTAL------------ 664
Cdd:PLN03192 531 TVASTGNAALLEELLKAKLDPDIGD---SKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALwnaisakhhkif 607
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 665 ------------HRGAVTGCE-------DCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAG 725
Cdd:PLN03192 608 rilyhfasisdpHAAGDLLCTaakrndlTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKANTD 687
|
....
gi 767973872 726 VDYS 729
Cdd:PLN03192 688 DDFS 691
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
248-438 |
3.16e-07 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 54.12 E-value: 3.16e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 248 PLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARY----GHELLISTLMTNGADTARRGIHDMFPLHLAVLF-- 321
Cdd:PHA02878 40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEpnklGMKEMIRSINKCSVFYTLVAIKDAFNNRNVEIFki 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 322 -------GFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPD-NLGRTCLHAAASGGNVECLNLLLSSGADLRRRDK 393
Cdd:PHA02878 120 iltnrykNIQTIDLVYIDKKSKDDIIEAEITKLLLSYGADINMKDrHKGNTALHYATENKDQRLTELLLSYGANVNIPDK 199
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 767973872 394 FGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAAS 438
Cdd:PHA02878 200 TNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVGY 244
|
|
| trp |
TIGR00870 |
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ... |
621-818 |
3.36e-07 |
|
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273311 [Multi-domain] Cd Length: 743 Bit Score: 54.32 E-value: 3.36e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 621 DVMDAYGQTPLM-LAIMNGHVDCVHLLLEKGSTADAadlrGRTALH---RGAVTGCEDCLAALLDHD----------AFV 686
Cdd:TIGR00870 46 NCPDRLGRSALFvAAIENENLELTELLLNLSCRGAV----GDTLLHaisLEYVDAVEAILLHLLAAFrksgplelanDQY 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 687 LCRDFKGRTPIHLASACGHTAVLRTLLQAALSTdPLDAGVD-----------YSGYSPMHWASYTGHEDCLELLLEHsPF 755
Cdd:TIGR00870 122 TSEFTPGITALHLAAHRQNYEIVKLLLERGASV-PARACGDffvksqgvdsfYHGESPLNAAACLGSPSIVALLSED-PA 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 756 SYLE----GNpfTPLHCAVINNQDST--TEM------LLGALGAKIVNSRDA------KGRTPLHAAAFADNVSGLRMLL 817
Cdd:TIGR00870 200 DILTadslGN--TLLHLLVMENEFKAeyEELscqmynFALSLLDKLRDSKELevilnhQGLTPLKLAAKEGRIVLFRLKL 277
|
.
gi 767973872 818 Q 818
Cdd:TIGR00870 278 A 278
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
599-682 |
3.58e-07 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 54.13 E-value: 3.58e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 599 AASGHTDSLHLLIDSGerADiTDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAA 678
Cdd:PTZ00322 90 AASGDAVGARILLTGG--AD-PNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQL 166
|
....
gi 767973872 679 LLDH 682
Cdd:PTZ00322 167 LSRH 170
|
|
| TRPV |
cd21882 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ... |
26-223 |
4.05e-07 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).
Pssm-ID: 411975 [Multi-domain] Cd Length: 600 Bit Score: 54.12 E-value: 4.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 26 EKVLGLL----LAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRS--------------GRSALHHAV 87
Cdd:cd21882 2 EELLGLLeclrWYLTDSAYQRGATGKTCLHKAALNLNDGVNEAIMLLLEAAPDSGNPkelvnapctdefyqGQTALHIAI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 88 HSGHLETVNLLLNKGASLNV--CDKKERQPLHWAAFLGHLEvlkllvargadlgckdrkgyglLHTAAASGQIEVVKYLL 165
Cdd:cd21882 82 ENRNLNLVRLLVENGADVSAraTGRFFRKSPGNLFYFGELP----------------------LSLAACTNQEEIVRLLL 139
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767973872 166 RMGAEIDEPNA---FGNTALHIACYLGQDAVAI---------ELVNAGANVNQ-------PNDKGFTPLHVAAVSTN 223
Cdd:cd21882 140 ENGAQPAALEAqdsLGNTVLHALVLQADNTPENsafvcqmynLLLSYGAHLDPtqqleeiPNHQGLTPLKLAAVEGK 216
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
660-713 |
4.13e-07 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 47.65 E-value: 4.13e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 767973872 660 GRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLL 713
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| TRPV3 |
cd22194 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ... |
554-713 |
5.82e-07 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.
Pssm-ID: 411978 [Multi-domain] Cd Length: 680 Bit Score: 53.61 E-value: 5.82e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 554 DHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPlhaaaasghtdslhllidsgeradiTDVMDAY--GQTPL 631
Cdd:cd22194 138 AYEGQTALNIAIERRQGDIVKLLIAKGADVNAHAKGVFFNP-------------------------KYKHEGFyfGETPL 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 632 MLAIMNGHVDCVHLLLEKGSTADAA-DLRGRTALHrGAVTGCEDclaaLLDHDAFVL-----------------CRDFKG 693
Cdd:cd22194 193 ALAACTNQPEIVQLLMEKESTDITSqDSRGNTVLH-ALVTVAED----SKTQNDFVKrmydmillksenknletIRNNEG 267
|
170 180
....*....|....*....|
gi 767973872 694 RTPIHLASACGHTAVLRTLL 713
Cdd:cd22194 268 LTPLQLAAKMGKAEILKYIL 287
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
145-198 |
6.05e-07 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 47.27 E-value: 6.05e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 767973872 145 GYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELV 198
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
247-297 |
6.23e-07 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 47.27 E-value: 6.23e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 767973872 247 SPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTL 297
Cdd:pfam13637 3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
526-576 |
6.54e-07 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 46.88 E-value: 6.54e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 767973872 526 SPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVL 576
Cdd:pfam13637 3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
119-282 |
6.89e-07 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 53.33 E-value: 6.89e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 119 AAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVaIELV 198
Cdd:PLN03192 532 VASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKI-FRIL 610
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 199 NAGANVNQPNDKGftPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCA---D 275
Cdd:PLN03192 611 YHFASISDPHAAG--DLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKAntdD 688
|
....*..
gi 767973872 276 KFGNTPL 282
Cdd:PLN03192 689 DFSPTEL 695
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
779-936 |
7.29e-07 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 53.14 E-value: 7.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 779 EMLLGalGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVE----------- 847
Cdd:PHA02876 162 EMLLE--GGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKaiidnrsnink 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 848 -----------------FLLYRGKADLTVLDENKNTALHLAC-SKGHEKCALMILAETQDlglINATNSALQMPLHIAAR 909
Cdd:PHA02876 240 ndlsllkairnedletsLLLYDAGFSVNSIDDCKNTPLHHASqAPSLSRLVPKLLERGAD---VNAKNIKGETPLYLMAK 316
|
170 180
....*....|....*....|....*...
gi 767973872 910 NGLASV-VQALLSHGATVLAVDEEGHTP 936
Cdd:PHA02876 317 NGYDTEnIRTLIMLGADVNAADRLYITP 344
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
166-298 |
8.14e-07 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 52.98 E-value: 8.14e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 166 RMGAeIDEPNAFGNTALHiACYLGQDAVAielvnaGANVNQPNDKGFTP--LHVAAV------STNGALCLELLVNNGAD 237
Cdd:PTZ00322 36 RMAA-IQEEIARIDTHLE-ALEATENKDA------TPDHNLTTEEVIDPvvAHMLTVelcqlaASGDAVGARILLTGGAD 107
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767973872 238 VNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLM 298
Cdd:PTZ00322 108 PNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLS 168
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
354-402 |
1.31e-06 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 46.19 E-value: 1.31e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 767973872 354 DINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYA 402
Cdd:pfam13857 8 DLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
784-850 |
1.32e-06 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 52.21 E-value: 1.32e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767973872 784 ALGAKIV-------NSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLL 850
Cdd:PTZ00322 95 AVGARILltggadpNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLS 168
|
|
| PHA02798 |
PHA02798 |
ankyrin-like protein; Provisional |
3-252 |
1.33e-06 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222931 [Multi-domain] Cd Length: 489 Bit Score: 52.14 E-value: 1.33e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 3 GANVNAKDTLWLTPLHRAAASRNE-----KVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLL---SSLNV 74
Cdd:PHA02798 61 GANVNGLDNEYSTPLCTILSNIKDykhmlDIVKILIENGADINKKNSDGETPLYCLLSNGYINNLEILLFMIengADTTL 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 75 ADRSGRSALHHAVHSGH---LETVNLLLNKGASLNVCDKKERQplhwaaflghlevlkllvargADLGCKDRKGYGLLht 151
Cdd:PHA02798 141 LDKDGFTMLQVYLQSNHhidIEIIKLLLEKGVDINTHNNKEKY---------------------DTLHCYFKYNIDRI-- 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 152 aaasgQIEVVKYLLRMGAEIDEPNAFGNTALhiACYLGQ--------DAVAIELVNAGANVNQPNDKGFTPLHVaAVSTN 223
Cdd:PHA02798 198 -----DADILKLFVDNGFIINKENKSHKKKF--MEYLNSllydnkrfKKNILDFIFSYIDINQVDELGFNPLYY-SVSHN 269
|
250 260
....*....|....*....|....*....
gi 767973872 224 GALCLELLVNNGADVNYQSKEGKSPLHMA 252
Cdd:PHA02798 270 NRKIFEYLLQLGGDINIITELGNTCLFTA 298
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
264-425 |
1.59e-06 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 52.18 E-value: 1.59e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 264 LIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSsgqlysiVSSL 343
Cdd:PLN03192 544 LLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILYH-------FASI 616
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 344 SNEHvlsAGFDIntpdnlgrtcLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNE 423
Cdd:PLN03192 617 SDPH---AAGDL----------LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDK 683
|
..
gi 767973872 424 AD 425
Cdd:PLN03192 684 AN 685
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
722-955 |
1.64e-06 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 51.53 E-value: 1.64e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 722 LDAGVD-----YSGYSPMHWASYTGHEDCLELLLEHSPF-SYLEGNPFTPLHCAVINNQDSTTEMLLgALGAKIVNSRDA 795
Cdd:PHA02875 22 LDIGINpnfeiYDGISPIKLAMKFRDSEAIKLLMKHGAIpDVKYPDIESELHDAVEEGDVKAVEELL-DLGKFADDVFYK 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 796 KGRTPLHAAAFADNVSGLRMLLQHQAE--VNATDHTgrTALMTAAENGQTAAVEFLLYrgkadltvldenkntalHLACS 873
Cdd:PHA02875 101 DGMTPLHLATILKKLDIMKLLIARGADpdIPNTDKF--SPLHLAVMMGDIKGIELLID-----------------HKACL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 874 KGHEKCALMilaetqdlglinatnsalqmPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALI 953
Cdd:PHA02875 162 DIEDCCGCT--------------------PLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAALCYAIENNKIDIVRLF 221
|
..
gi 767973872 954 LS 955
Cdd:PHA02875 222 IK 223
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
369-543 |
2.07e-06 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 51.55 E-value: 2.07e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 369 AASGGNVECLN-LLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAG-VNEADC----KGCSPLHYAAASDTY- 441
Cdd:cd22192 24 AAKENDVQAIKkLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPElVNEPMTsdlyQGETALHIAVVNQNLn 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 442 -------RRAEPHTPsshdaeedeplkesRRKEAFF-------------------C------LEFLLDNGADPSLRDRQG 489
Cdd:cd22192 104 lvreliaRGADVVSP--------------RATGTFFrpgpknliyygehplsfaaCvgneeiVRLLIEHGADIRAQDSLG 169
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767973872 490 YTAVHYAAAYGNR----QNLELLLEMSFN----CLEDVESTIPVSPLHLAAYNGHCEALKTL 543
Cdd:cd22192 170 NTVLHILVLQPNKtfacQMYDLILSYDKEddlqPLDLVPNNQGLTPFKLAAKEGNIVMFQHL 231
|
|
| TRPV |
cd21882 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ... |
362-631 |
2.27e-06 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).
Pssm-ID: 411975 [Multi-domain] Cd Length: 600 Bit Score: 51.42 E-value: 2.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 362 GRTCLHAAA---SGGNVECLNLLLSSGADLRRRDKF-----------GRTPLHYAAANGSYQCAVTLVTAGAGVNeadck 427
Cdd:cd21882 26 GKTCLHKAAlnlNDGVNEAIMLLLEAAPDSGNPKELvnapctdefyqGQTALHIAIENRNLNLVRLLVENGADVS----- 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 428 gcsplhyAAASDTYRRAEPHtPSSHDAEEDEPLKESRRKEAFfcLEFLLDNGADP---SLRDRQGYTAVHyaaaygnrqn 504
Cdd:cd21882 101 -------ARATGRFFRKSPG-NLFYFGELPLSLAACTNQEEI--VRLLLENGAQPaalEAQDSLGNTVLH---------- 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 505 leLLLEMSFNCLEDVESTIPVSPLhLAAYNGHCEALKTLAEtlvnldVRDHKGRTALFLATERGSTECVEVLTAHGASAL 584
Cdd:cd21882 161 --ALVLQADNTPENSAFVCQMYNL-LLSYGAHLDPTQQLEE------IPNHQGLTPLKLAAVEGKIVMFQHILQREFSGP 231
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 767973872 585 IKERKRK---WT--PLHAAA-------ASGHTDSLHLLIDSGERADITDVMDaygQTPL 631
Cdd:cd21882 232 YQPLSRKfteWTygPVTSSLydlseidSWEKNSVLELIAFSKKREARHQMLV---QEPL 287
|
|
| TRPV1-4 |
cd22193 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are ... |
547-753 |
2.48e-06 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are thermo-sensing channels that function directly in temperature-sensing and nociception; they share substantial structural and functional properties. Transient Receptor Potential (TRP) ion channels activated by temperature (thermo TRPs) are important molecular players in acute, inflammatory, and chronic pain states. So far, 11 TRP channels in mammalian cells have been identified as thermosensitive TRP (thermo-TRP) channels. TRPV1-4 channels are activated by different heat temperatures, for example, TRPV1 and TRPV2 are activated by high temperatures (>43C and >55C, respectively). TRPV1-4 belong to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.
Pssm-ID: 411977 [Multi-domain] Cd Length: 607 Bit Score: 51.33 E-value: 2.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 547 LVNLDVRD--HKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPlhaaaASGHTDSLhllidsgeraditdvmd 624
Cdd:cd22193 64 FINAEYTDeyYEGQTALHIAIERRQGDIVALLVENGADVHAHAKGRFFQP-----KYQGEGFY----------------- 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 625 aYGQTPLMLAIMNGHVDCVHLLLE---KGSTADAADLRGRTALHrGAVTGCEDclaaLLDHDAFV-------------LC 688
Cdd:cd22193 122 -FGELPLSLAACTNQPDIVQYLLEnehQPADIEAQDSRGNTVLH-ALVTVADN----TKENTKFVtrmydmilirgakLC 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 689 --------RDFKGRTPIHLASACGHTAVLRTLLQAALSTDP---LDAGVDYSGYSPMHWASY-------TGHEDCLELLL 750
Cdd:cd22193 196 ptveleeiRNNDGLTPLQLAAKMGKIEILKYILQREIKEPElrhLSRKFTDWAYGPVSSSLYdlsnvdtCEKNSVLEIIV 275
|
...
gi 767973872 751 EHS 753
Cdd:cd22193 276 YNS 278
|
|
| PHA02791 |
PHA02791 |
ankyrin-like protein; Provisional |
62-166 |
2.84e-06 |
|
ankyrin-like protein; Provisional
Pssm-ID: 165154 [Multi-domain] Cd Length: 284 Bit Score: 50.04 E-value: 2.84e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 62 AEALAPLLSSLNV--ADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKerQPLHWAAFLGHLEVLKLLVARGADLG 139
Cdd:PHA02791 11 SKQLKSFLSSKDAfkADVHGHSALYYAIADNNVRLVCTLLNAGALKNLLENE--FPLHQAATLEDTKIVKILLFSGMDDS 88
|
90 100
....*....|....*....|....*..
gi 767973872 140 CKDRKGYGLLHTAAASGQIEVVKYLLR 166
Cdd:PHA02791 89 QFDDKGNTALYYAVDSGNMQTVKLFVK 115
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
459-636 |
3.24e-06 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 50.76 E-value: 3.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 459 PLKESRRKEAFFCLEFLLDNG--ADPSLRdRQGYTAVHYAAAYGNRQNLELLLEMSFNclEDVESTIPVSPLHLAAYNGH 536
Cdd:PHA02875 71 ELHDAVEEGDVKAVEELLDLGkfADDVFY-KDGMTPLHLATILKKLDIMKLLIARGAD--PDIPNTDKFSPLHLAVMMGD 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 537 CEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGER 616
Cdd:PHA02875 148 IKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAALCYAIENNKIDIVRLFIKRGAD 227
|
170 180
....*....|....*....|.
gi 767973872 617 ADI-TDVMDAYGQTPLMLAIM 636
Cdd:PHA02875 228 CNImFMIEGEECTILDMICNM 248
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
802-922 |
3.57e-06 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 51.05 E-value: 3.57e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 802 HAAAFADNVsGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGkADLTVLDENKNTalhlacskghekcal 881
Cdd:PTZ00322 88 QLAASGDAV-GARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFG-ADPTLLDKDGKT--------------- 150
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 767973872 882 milaetqdlglinatnsalqmPLHIAARNGLASVVQALLSH 922
Cdd:PTZ00322 151 ---------------------PLELAEENGFREVVQLLSRH 170
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
521-837 |
4.62e-06 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 50.26 E-value: 4.62e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 521 STIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLAtergsteCVEVlTAHGASALIKER-KRK-WTPLHAA 598
Cdd:PHA02878 34 SLIPFIPLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHII-------CKEP-NKLGMKEMIRSInKCSvFYTLVAI 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 599 AASGHTDSLH----LLIDSGERadITDVMDAYGQTPLMLAIMNGHVdcVHLLLEKGSTADAADL-RGRTALHRGAVTGCE 673
Cdd:PHA02878 106 KDAFNNRNVEifkiILTNRYKN--IQTIDLVYIDKKSKDDIIEAEI--TKLLLSYGADINMKDRhKGNTALHYATENKDQ 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 674 DCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAgvdySGYSPMHWA-SYTGHEDCLELLLEH 752
Cdd:PHA02878 182 RLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDK----CGNTPLHISvGYCKDYDILKLLLEH 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 753 SpfsylegnpftplhcAVINNQDSTtemllgalgakivnsrdaKGRTPLHAAAFADNVsgLRMLLQHQAEVNATDHTGRT 832
Cdd:PHA02878 258 G---------------VDVNAKSYI------------------LGLTALHSSIKSERK--LKLLLEYGADINSLNSYKLT 302
|
....*
gi 767973872 833 ALMTA 837
Cdd:PHA02878 303 PLSSA 307
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
472-582 |
1.08e-05 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 49.48 E-value: 1.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 472 LEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNC-LEDVESTI----PVSPLH----------------- 529
Cdd:PLN03192 541 LEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVhIRDANGNTalwnAISAKHhkifrilyhfasisdph 620
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 530 -------LAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGAS 582
Cdd:PLN03192 621 aagdllcTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGAD 680
|
|
| PHA02859 |
PHA02859 |
ankyrin repeat protein; Provisional |
155-299 |
1.09e-05 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165195 [Multi-domain] Cd Length: 209 Bit Score: 47.51 E-value: 1.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 155 SGQIEVVKYLLRMgaeIDEPNAFGNTALHiACyLGQDAVAIE----LVNAGANVN-QPNDKGFTPLHvAAVSTNGAL--- 226
Cdd:PHA02859 31 KDDIEGVKKWIKF---VNDCNDLYETPIF-SC-LEKDKVNVEilkfLIENGADVNfKTRDNNLSALH-HYLSFNKNVepe 104
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767973872 227 CLELLVNNGADVNYQSKEGKSPLH--MAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMT 299
Cdd:PHA02859 105 ILKILIDSGSSITEEDEDGKNLLHmyMCNFNVRINVIKLLIDSGVSFLNKDFDNNNILYSYILFHSDKKIFDFLT 179
|
|
| trp |
TIGR00870 |
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ... |
486-714 |
1.11e-05 |
|
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273311 [Multi-domain] Cd Length: 743 Bit Score: 49.31 E-value: 1.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 486 DRQGYTAVHYAAAYGNRQNLELLLEmSFNCLEDVESTIpvspLHLAA--YNGHCEAL---------KTLAETLVNLDVRD 554
Cdd:TIGR00870 49 DRLGRSALFVAAIENENLELTELLL-NLSCRGAVGDTL----LHAISleYVDAVEAIllhllaafrKSGPLELANDQYTS 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 555 --HKGRTALFLATERGSTECVEVLTAHGASalikerkrkwtpLHAAA------ASGHTDSLHllidsgeraditdvmdaY 626
Cdd:TIGR00870 124 efTPGITALHLAAHRQNYEIVKLLLERGAS------------VPARAcgdffvKSQGVDSFY-----------------H 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 627 GQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALH------------RGAVTGCEDCLAALLDHdafvlCRD---- 690
Cdd:TIGR00870 175 GESPLNAAACLGSPSIVALLSEDPADILTADSLGNTLLHllvmenefkaeyEELSCQMYNFALSLLDK-----LRDskel 249
|
250 260
....*....|....*....|....*....
gi 767973872 691 -----FKGRTPIHLASACGHTAVLRTLLQ 714
Cdd:TIGR00870 250 evilnHQGLTPLKLAAKEGRIVLFRLKLA 278
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
48-99 |
1.22e-05 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 43.42 E-value: 1.22e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 767973872 48 TPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLL 99
Cdd:pfam13637 3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| PHA02989 |
PHA02989 |
ankyrin repeat protein; Provisional |
27-256 |
1.25e-05 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222954 [Multi-domain] Cd Length: 494 Bit Score: 48.97 E-value: 1.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 27 KVLGLLLAHSADVNARDkLWQTPLHVAAANR--ATKCAEALAPLL----SSLNVADRSGRSALHHAVHSGHLETVN---L 97
Cdd:PHA02989 51 KIVKLLIDNGADVNYKG-YIETPLCAVLRNReiTSNKIKKIVKLLlkfgADINLKTFNGVSPIVCFIYNSNINNCDmlrF 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 98 LLNKGASLN-VCDKKERQPLH--WAAFLGHLEVLKLLVARGADLgCKDRKGYGL------LHTAAASGQIEVVKYLLRMG 168
Cdd:PHA02989 130 LLSKGINVNdVKNSRGYNLLHmyLESFSVKKDVIKILLSFGVNL-FEKTSLYGLtpmniyLRNDIDVISIKVIKYLIKKG 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 169 AEIDEPNAFGNTAL------HIACYlGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLvNNGADVNYQS 242
Cdd:PHA02989 209 VNIETNNNGSESVLesfldnNKILS-KKEFKVLNFILKYIKINKKDKKGFNPLLISAKVDNYEAFNYLL-KLGDDIYNVS 286
|
250
....*....|....
gi 767973872 243 KEGKSPLHMAAIHG 256
Cdd:PHA02989 287 KDGDTVLTYAIKHG 300
|
|
| TRPV3 |
cd22194 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ... |
169-289 |
1.36e-05 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.
Pssm-ID: 411978 [Multi-domain] Cd Length: 680 Bit Score: 48.99 E-value: 1.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 169 AEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVN--------QPNDK--GF----TPLHVAAVsTNGALCLELLVNN 234
Cdd:cd22194 132 AEYTEEAYEGQTALNIAIERRQGDIVKLLIAKGADVNahakgvffNPKYKheGFyfgeTPLALAAC-TNQPEIVQLLMEK 210
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767973872 235 GAD-VNYQSKEGKSPLHMAAIHGRFTRSQI--LIQNGSEI--DCADKF--------GNTPLHVAARYG 289
Cdd:cd22194 211 ESTdITSQDSRGNTVLHALVTVAEDSKTQNdfVKRMYDMIllKSENKNletirnneGLTPLQLAAKMG 278
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
230-285 |
1.37e-05 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 43.49 E-value: 1.37e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 767973872 230 LLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVA 285
Cdd:pfam13857 1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
130-185 |
1.40e-05 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 43.49 E-value: 1.40e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 767973872 130 LLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIA 185
Cdd:pfam13857 1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
197-252 |
1.43e-05 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 43.49 E-value: 1.43e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 767973872 197 LVNAG-ANVNQPNDKGFTPLHVAAvSTNGALCLELLVNNGADVNYQSKEGKSPLHMA 252
Cdd:pfam13857 1 LLEHGpIDLNRLDGEGYTPLHVAA-KYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
213-265 |
1.48e-05 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 43.42 E-value: 1.48e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 767973872 213 TPLHVAAVSTNGAlCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILI 265
Cdd:pfam13637 3 TALHAAAASGHLE-LLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
348-406 |
2.16e-05 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 48.36 E-value: 2.16e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 767973872 348 VLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANG 406
Cdd:PTZ00322 101 LLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENG 159
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
3-107 |
2.86e-05 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 47.68 E-value: 2.86e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 3 GANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGR-S 81
Cdd:PHA02875 125 GADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCvA 204
|
90 100
....*....|....*....|....*.
gi 767973872 82 ALHHAVHSGHLETVNLLLNKGASLNV 107
Cdd:PHA02875 205 ALCYAIENNKIDIVRLFIKRGADCNI 230
|
|
| TRPV |
cd21882 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ... |
176-284 |
2.95e-05 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).
Pssm-ID: 411975 [Multi-domain] Cd Length: 600 Bit Score: 47.95 E-value: 2.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 176 AFGNTALHIAC-YL--GQDAVAIELVNAGANVNQPND-----------KGFTPLHVAAVSTNgALCLELLVNNGADVNYQ 241
Cdd:cd21882 24 ATGKTCLHKAAlNLndGVNEAIMLLLEAAPDSGNPKElvnapctdefyQGQTALHIAIENRN-LNLVRLLVENGADVSAR 102
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 767973872 242 SKE-------------GKSPLHMAAIHGRFTRSQILIQNGSEI---DCADKFGNTPLHV 284
Cdd:cd21882 103 ATGrffrkspgnlfyfGELPLSLAACTNQEEIVRLLLENGAQPaalEAQDSLGNTVLHA 161
|
|
| trp |
TIGR00870 |
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ... |
548-714 |
3.29e-05 |
|
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273311 [Multi-domain] Cd Length: 743 Bit Score: 47.77 E-value: 3.29e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 548 VNLDVRDHKGRTALFLATERGST-ECVEVLTAHGASALIKErkrkwTPLHAAAASGHTD----SLHLLIDSGERADITDV 622
Cdd:TIGR00870 43 LNINCPDRLGRSALFVAAIENENlELTELLLNLSCRGAVGD-----TLLHAISLEYVDAveaiLLHLLAAFRKSGPLELA 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 623 MDAY------GQTPLMLAIMNGHVDCVHLLLEKGSTADAAdlrgrtalhrgavTGCEDCLAAlLDHDAFvlcrdFKGRTP 696
Cdd:TIGR00870 118 NDQYtseftpGITALHLAAHRQNYEIVKLLLERGASVPAR-------------ACGDFFVKS-QGVDSF-----YHGESP 178
|
170
....*....|....*...
gi 767973872 697 IHLASACGHTAVLRTLLQ 714
Cdd:TIGR00870 179 LNAAACLGSPSIVALLSE 196
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
830-884 |
3.56e-05 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 42.26 E-value: 3.56e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 767973872 830 GRTALMTAAENGQTAAVEFLLYRGkADLTVLDENKNTALHLACSKGHEKCALMIL 884
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKG-ADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| PHA02859 |
PHA02859 |
ankyrin repeat protein; Provisional |
92-214 |
3.64e-05 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165195 [Multi-domain] Cd Length: 209 Bit Score: 45.97 E-value: 3.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 92 LETVNLLLNKGASLNVCDKKER-QPLHWaaFLGH-----LEVLKLLVARGADLGCKDRKGYGLLHT--AAASGQIEVVKY 163
Cdd:PHA02859 66 VEILKFLIENGADVNFKTRDNNlSALHH--YLSFnknvePEILKILIDSGSSITEEDEDGKNLLHMymCNFNVRINVIKL 143
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 767973872 164 LLRMGAEIDEPNAFGNTALH-IACYLGQDAVAIELVNAGANVNQPNDKGFTP 214
Cdd:PHA02859 144 LIDSGVSFLNKDFDNNNILYsYILFHSDKKIFDFLTSLGIDINETNKSGYNC 195
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
629-680 |
3.81e-05 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 42.26 E-value: 3.81e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 767973872 629 TPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALL 680
Cdd:pfam13637 3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
456-509 |
4.00e-05 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 41.88 E-value: 4.00e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 767973872 456 EDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLL 509
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| TRPV |
cd21882 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ... |
505-753 |
4.61e-05 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).
Pssm-ID: 411975 [Multi-domain] Cd Length: 600 Bit Score: 47.18 E-value: 4.61e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 505 LELLLEMSFNCLEDVESTIPV---SPLHLAAYNGHCEALKTLA------------ETLVNLDVRD--HKGRTALFLATER 567
Cdd:cd21882 4 LLGLLECLRWYLTDSAYQRGAtgkTCLHKAALNLNDGVNEAIMllleaapdsgnpKELVNAPCTDefYQGQTALHIAIEN 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 568 GSTECVEVLTAHGASAlikerkrkwtplhAAAASGH--TDSLHLLIdsgeraditdvmdAYGQTPLMLAIMNGHVDCVHL 645
Cdd:cd21882 84 RNLNLVRLLVENGADV-------------SARATGRffRKSPGNLF-------------YFGELPLSLAACTNQEEIVRL 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 646 LLEKG---STADAADLRGRTALH------------RGAVTGCEDCLAAL---LDH-DAFVLCRDFKGRTPIHLASACGHT 706
Cdd:cd21882 138 LLENGaqpAALEAQDSLGNTVLHalvlqadntpenSAFVCQMYNLLLSYgahLDPtQQLEEIPNHQGLTPLKLAAVEGKI 217
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 767973872 707 AVLRTLLQAALST--DPLDAGVDYSGYSPMHWASY-------TGHEDCLELLLEHS 753
Cdd:cd21882 218 VMFQHILQREFSGpyQPLSRKFTEWTYGPVTSSLYdlseidsWEKNSVLELIAFSK 273
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
730-782 |
5.07e-05 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 41.88 E-value: 5.07e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 767973872 730 GYSPMHWASYTGHEDCLELLLEHS-PFSYLEGNPFTPLHCAVINNQDSTTEMLL 782
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGaDINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| trp |
TIGR00870 |
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ... |
269-533 |
5.30e-05 |
|
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273311 [Multi-domain] Cd Length: 743 Bit Score: 47.38 E-value: 5.30e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 269 SEIDCADKFGNTPLHVAARYG-HELLISTLMTNGA-----DTArrgihdmfpLHLAVLfGFSDCCRKLLSSgQLYSIVSS 342
Cdd:TIGR00870 43 LNINCPDRLGRSALFVAAIENeNLELTELLLNLSCrgavgDTL---------LHAISL-EYVDAVEAILLH-LLAAFRKS 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 343 LSNEHVLSAGFDINTPDnlgRTCLHAAASGGNVECLNLLLSSGADLRRRDK--------------FGRTPLHYAAANGSY 408
Cdd:TIGR00870 112 GPLELANDQYTSEFTPG---ITALHLAAHRQNYEIVKLLLERGASVPARACgdffvksqgvdsfyHGESPLNAAACLGSP 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 409 QCAVTLVTAGAGVNEADCKGCSPLHyAAASDTYRRAEPHTPSSHdaeedeplkesrrkeaffCLEFLLDNGA--DPSL-- 484
Cdd:TIGR00870 189 SIVALLSEDPADILTADSLGNTLLH-LLVMENEFKAEYEELSCQ------------------MYNFALSLLDklRDSKel 249
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 767973872 485 ---RDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVEStiPVSPLHLAAY 533
Cdd:TIGR00870 250 eviLNHQGLTPLKLAAKEGRIVLFRLKLAIKYKQKKFVAW--PNGQQLLSLY 299
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
693-750 |
5.53e-05 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 41.49 E-value: 5.53e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 767973872 693 GRTPIHLASACGHTAVLRTLLQAALSTDPldagVDYSGYSPMHWASYTGHEDCLELLL 750
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINA----VDGNGETALHFAASNGNVEVLKLLL 54
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
79-107 |
6.32e-05 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 40.65 E-value: 6.32e-05
10 20
....*....|....*....|....*....
gi 767973872 79 GRSALHHAVHSGHLETVNLLLNKGASLNV 107
Cdd:smart00248 2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
31-86 |
6.61e-05 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 41.56 E-value: 6.61e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 767973872 31 LLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHA 86
Cdd:pfam13857 1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
761-946 |
6.91e-05 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 46.58 E-value: 6.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 761 NPFTPLHCAVINNQDSTTEMLLgALGAKIVNSRDaKGRTPLHAAAFA-----DNVSGLRMLLQHQAEVNATDHTGRTALM 835
Cdd:PHA03100 34 KPVLPLYLAKEARNIDVVKILL-DNGADINSSTK-NNSTPLHYLSNIkynltDVKEIVKLLLEYGANVNAPDNNGITPLL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 836 TAAEN--GQTAAVEFLLYRGkADLTVLDENKNTALHLACSKGHEK---CALMIlaetqDLGL-INATNSalqmplhiaar 909
Cdd:PHA03100 112 YAISKksNSYSIVEYLLDNG-ANVNIKNSDGENLLHLYLESNKIDlkiLKLLI-----DKGVdINAKNR----------- 174
|
170 180 190
....*....|....*....|....*....|....*....
gi 767973872 910 nglasvVQALLSHGATVLAVDEEGHTPAL-AC-APNKDV 946
Cdd:PHA03100 175 ------VNYLLSYGVPINIKDVYGFTPLHyAVyNNNPEF 207
|
|
| PHA02946 |
PHA02946 |
ankyin-like protein; Provisional |
346-432 |
9.28e-05 |
|
ankyin-like protein; Provisional
Pssm-ID: 165256 [Multi-domain] Cd Length: 446 Bit Score: 46.20 E-value: 9.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 346 EHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGS--YQCAVTLVTAGAGVNE 423
Cdd:PHA02946 56 EELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTDDevIERINLLVQYGAKINN 135
|
90
....*....|
gi 767973872 424 A-DCKGCSPL 432
Cdd:PHA02946 136 SvDEEGCGPL 145
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
210-243 |
9.47e-05 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 40.35 E-value: 9.47e-05
10 20 30
....*....|....*....|....*....|....
gi 767973872 210 KGFTPLHVAAVSTNGALCLELLVNNGADVNYQSK 243
Cdd:pfam00023 1 DGNTPLHLAAGRRGNLEIVKLLLSKGADVNARDK 34
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
278-331 |
1.04e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 40.72 E-value: 1.04e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 767973872 278 GNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLL 331
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
293-514 |
1.06e-04 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 45.75 E-value: 1.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 293 LISTLMTNGADTARR----GIHDMF-------PLHLAVLFGFSDCCRKLLSSGQLYsivsslsnehvlsagfDINTPDNl 361
Cdd:PHA02875 6 LCDAILFGELDIARRlldiGINPNFeiydgisPIKLAMKFRDSEAIKLLMKHGAIP----------------DVKYPDI- 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 362 gRTCLHAAASGGNVECLNLLLSSGA---DLRRRDkfGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAAS 438
Cdd:PHA02875 69 -ESELHDAVEEGDVKAVEELLDLGKfadDVFYKD--GMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMM 145
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767973872 439 DTYRRaephtpsshdaeedeplkesrrkeaffcLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFN 514
Cdd:PHA02875 146 GDIKG----------------------------IELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGAN 193
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
314-382 |
1.19e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 40.72 E-value: 1.19e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767973872 314 PLHLAVLFGFSDCCRKLLSSGqlysivsslsnehvlsagFDINTPDNLGRTCLHAAASGGNVECLNLLL 382
Cdd:pfam13637 4 ALHAAAASGHLELLRLLLEKG------------------ADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| TRPV1 |
cd22196 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 ... |
210-283 |
1.23e-04 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 (TRPV1), a capsaicin (vanilloid) receptor, is the founding member of the vanilloid TRP subfamily (TRPV). In humans, it is expressed in the brain, kidney, pancreas, testis, uterus, spleen, stomach, small intestine, lung and liver. TRPV1 has been implicated to have function in thermo-sensation (heat), autonomic thermoregulation, nociception, food intake regulation, and multiple functions in the gastrointestinal (GI) tract. The receptor has also been involved in growth cone guidance, long-term depression, endocannabinoid signaling and osmosensing in the central nervous system. TRPV1 is up regulated in several human pathological conditions including vulvodynia, GI inflammation, Crohn's disease and ulcerative colitis. TRPV1 knock-out mice exhibit impaired sensation to thermal-mechanical acute pain. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.
Pssm-ID: 411980 [Multi-domain] Cd Length: 649 Bit Score: 45.95 E-value: 1.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 210 KGFTPLHVAAVSTNGALcLELLVNNGADVN-------YQSKEGKS-------PLHMAAIHGRFTRSQILIQN---GSEID 272
Cdd:cd22196 93 KGQTALHIAIERRNMHL-VELLVQNGADVHarasgefFKKKKGGPgfyfgelPLSLAACTNQLDIVKFLLENphsPADIS 171
|
90
....*....|.
gi 767973872 273 CADKFGNTPLH 283
Cdd:cd22196 172 ARDSMGNTVLH 182
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
153-253 |
1.29e-04 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 46.04 E-value: 1.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 153 AASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALcLELLV 232
Cdd:PTZ00322 90 AASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREV-VQLLS 168
|
90 100 110
....*....|....*....|....*....|....
gi 767973872 233 -------NNGADVNYQSKEGK------SPLHMAA 253
Cdd:PTZ00322 169 rhsqchfELGANAKPDSFTGKppsledSPISSHH 202
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
250-338 |
1.46e-04 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 45.66 E-value: 1.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 250 HMAAiHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRK 329
Cdd:PTZ00322 88 QLAA-SGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQL 166
|
....*....
gi 767973872 330 LLSSGQLYS 338
Cdd:PTZ00322 167 LSRHSQCHF 175
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
386-435 |
1.48e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 40.41 E-value: 1.48e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 767973872 386 ADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYA 435
Cdd:pfam13857 7 IDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
626-655 |
1.75e-04 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 39.49 E-value: 1.75e-04
10 20 30
....*....|....*....|....*....|
gi 767973872 626 YGQTPLMLAIMNGHVDCVHLLLEKGSTADA 655
Cdd:smart00248 1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
|
|
| PHA02946 |
PHA02946 |
ankyin-like protein; Provisional |
791-956 |
1.88e-04 |
|
ankyin-like protein; Provisional
Pssm-ID: 165256 [Multi-domain] Cd Length: 446 Bit Score: 45.04 E-value: 1.88e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 791 NSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTAL--MTAAENGQTAAVEFLLYRGKADLTVLDENKNTAL 868
Cdd:PHA02946 66 NETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLyyLSGTDDEVIERINLLVQYGAKINNSVDEEGCGPL 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 869 hLACSKGHEKCALMILAETQDLGLINATNSAlQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPA-LACAPNKDVA 947
Cdd:PHA02946 146 -LACTDPSERVFKKIMSIGFEARIVDKFGKN-HIHRHLMSDNPKASTISWMMKLGISPSKPDHDGNTPLhIVCSKTVKNV 223
|
....*....
gi 767973872 948 DCLALILST 956
Cdd:PHA02946 224 DIINLLLPS 232
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
129-185 |
2.02e-04 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 45.27 E-value: 2.02e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 767973872 129 KLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIA 185
Cdd:PTZ00322 99 RILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELA 155
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
79-110 |
2.23e-04 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 39.19 E-value: 2.23e-04
10 20 30
....*....|....*....|....*....|...
gi 767973872 79 GRSALHHAV-HSGHLETVNLLLNKGASLNVCDK 110
Cdd:pfam00023 2 GNTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
816-871 |
2.81e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 39.64 E-value: 2.81e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 767973872 816 LLQH-QAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGkADLTVLDENKNTALHLA 871
Cdd:pfam13857 1 LLEHgPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYG-VDLNLKDEEGLTALDLA 56
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
865-920 |
3.06e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 39.57 E-value: 3.06e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 767973872 865 NTALHLACSKGHEKCALMILAETQDlglINATNSALQMPLHIAARNGLASVVQALL 920
Cdd:pfam13637 2 LTALHAAAASGHLELLRLLLEKGAD---INAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| PHA02946 |
PHA02946 |
ankyin-like protein; Provisional |
95-297 |
3.92e-04 |
|
ankyin-like protein; Provisional
Pssm-ID: 165256 [Multi-domain] Cd Length: 446 Bit Score: 44.27 E-value: 3.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 95 VNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQ--IEVVKYLLRMGAEID 172
Cdd:PHA02946 55 VEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTDDevIERINLLVQYGAKIN 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 173 EPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTN-GALCLELLVNNGADVNYQSKEGKSPLHM 251
Cdd:PHA02946 135 NSVDEEGCGPLLACTDPSERVFKKIMSIGFEARIVDKFGKNHIHRHLMSDNpKASTISWMMKLGISPSKPDHDGNTPLHI 214
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 767973872 252 AAIHGRFTRSQI-LIQNGSEIDCADKFGNTPLhvaaryghELLISTL 297
Cdd:PHA02946 215 VCSKTVKNVDIInLLLPSTDVNKQNKFGDSPL--------TLLIKTL 253
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
97-152 |
3.96e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 39.25 E-value: 3.96e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 767973872 97 LLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTA 152
Cdd:pfam13857 1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
362-388 |
4.77e-04 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 38.34 E-value: 4.77e-04
10 20
....*....|....*....|....*..
gi 767973872 362 GRTCLHAAASGGNVECLNLLLSSGADL 388
Cdd:smart00248 2 GRTPLHLAAENGNLEVVKLLLDKGADI 28
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
799-970 |
4.88e-04 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 43.85 E-value: 4.88e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 799 TPLHAAAFADNVSGL-RMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFL---------------LYRGKadltvlde 862
Cdd:cd22192 19 SPLLLAAKENDVQAIkKLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLmeaapelvnepmtsdLYQGE-------- 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 863 nknTALHLACSKGHEKCALMILAETQDLGLINATNSAL-----------QMPLHIAARNGLASVVQALLSHGATVLAVDE 931
Cdd:cd22192 91 ---TALHIAVVNQNLNLVRELIARGADVVSPRATGTFFrpgpknliyygEHPLSFAACVGNEEIVRLLIEHGADIRAQDS 167
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 767973872 932 EGHTP--ALACAPNKDVAdCLA--LILSTMKP--------FPPKDAVSPFS 970
Cdd:cd22192 168 LGNTVlhILVLQPNKTFA-CQMydLILSYDKEddlqpldlVPNNQGLTPFK 217
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
557-611 |
6.22e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 38.79 E-value: 6.22e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 767973872 557 GRTALFLATERGSTECVEVLTAHGASALIKERkRKWTPLHAAAASGHTDSLHLLI 611
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDG-NGETALHFAASNGNVEVLKLLL 54
|
|
| PHA02989 |
PHA02989 |
ankyrin repeat protein; Provisional |
158-435 |
6.49e-04 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222954 [Multi-domain] Cd Length: 494 Bit Score: 43.58 E-value: 6.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 158 IEVVKYLLRMGAEIDEPNAfGNTALHIacYLGQDAVAIE----LVNAGANVNQpndKGF--TPLhvAAVSTNGALC---- 227
Cdd:PHA02989 16 KNALEFLLRTGFDVNEEYR-GNSILLL--YLKRKDVKIKivklLIDNGADVNY---KGYieTPL--CAVLRNREITsnki 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 228 ---LELLVNNGADVNYQSKEGKSPLhMAAIHGrftrsqiliqngSEIDCADkfgntplhvaaryghelLISTLMTNGADT 304
Cdd:PHA02989 88 kkiVKLLLKFGADINLKTFNGVSPI-VCFIYN------------SNINNCD-----------------MLRFLLSKGINV 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 305 ARRGIHDMFPLHLAVLFGFS---DCCRKLLSSG-------QLY-------------SIVSSLSNEHVLSAGFDINTPDNL 361
Cdd:PHA02989 138 NDVKNSRGYNLLHMYLESFSvkkDVIKILLSFGvnlfektSLYgltpmniylrndiDVISIKVIKYLIKKGVNIETNNNG 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 362 GRTCL------HAAASGGNVECLNLLLSSgADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYA 435
Cdd:PHA02989 218 SESVLesfldnNKILSKKEFKVLNFILKY-IKINKKDKKGFNPLLISAKVDNYEAFNYLLKLGDDIYNVSKDGDTVLTYA 296
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
21-99 |
8.77e-04 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 43.35 E-value: 8.77e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767973872 21 AASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLL 99
Cdd:PTZ00322 90 AASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLS 168
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
889-936 |
8.79e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 38.48 E-value: 8.79e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 767973872 889 DLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTP 936
Cdd:pfam13857 5 GPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTA 52
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
362-393 |
8.99e-04 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 37.65 E-value: 8.99e-04
10 20 30
....*....|....*....|....*....|...
gi 767973872 362 GRTCLHAAA-SGGNVECLNLLLSSGADLRRRDK 393
Cdd:pfam00023 2 GNTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
|
|
| Ank_3 |
pfam13606 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
626-655 |
1.17e-03 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.
Pssm-ID: 463933 [Multi-domain] Cd Length: 30 Bit Score: 37.24 E-value: 1.17e-03
10 20 30
....*....|....*....|....*....|
gi 767973872 626 YGQTPLMLAIMNGHVDCVHLLLEKGSTADA 655
Cdd:pfam13606 1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
764-817 |
1.30e-03 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 37.64 E-value: 1.30e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 767973872 764 TPLHCAVINNQDSTTEMLLgALGAKIvNSRDAKGRTPLHAAAFADNVSGLRMLL 817
Cdd:pfam13637 3 TALHAAAASGHLELLRLLL-EKGADI-NAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| TRPV1-4 |
cd22193 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are ... |
210-283 |
1.61e-03 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are thermo-sensing channels that function directly in temperature-sensing and nociception; they share substantial structural and functional properties. Transient Receptor Potential (TRP) ion channels activated by temperature (thermo TRPs) are important molecular players in acute, inflammatory, and chronic pain states. So far, 11 TRP channels in mammalian cells have been identified as thermosensitive TRP (thermo-TRP) channels. TRPV1-4 channels are activated by different heat temperatures, for example, TRPV1 and TRPV2 are activated by high temperatures (>43C and >55C, respectively). TRPV1-4 belong to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.
Pssm-ID: 411977 [Multi-domain] Cd Length: 607 Bit Score: 42.48 E-value: 1.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 210 KGFTPLHVAAVSTNGAlCLELLVNNGADVNYQSKE--------------GKSPLHMAAIHGRFTRSQILIQNG---SEID 272
Cdd:cd22193 75 EGQTALHIAIERRQGD-IVALLVENGADVHAHAKGrffqpkyqgegfyfGELPLSLAACTNQPDIVQYLLENEhqpADIE 153
|
90
....*....|.
gi 767973872 273 CADKFGNTPLH 283
Cdd:cd22193 154 AQDSRGNTVLH 164
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
901-968 |
1.80e-03 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 42.19 E-value: 1.80e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767973872 901 QMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPaLACAPNKDVADCLALILSTMKPFPPKDAVSP 968
Cdd:PTZ00322 116 RTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTP-LELAEENGFREVVQLLSRHSQCHFELGANAK 182
|
|
| Ank_3 |
pfam13606 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
79-107 |
1.99e-03 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.
Pssm-ID: 463933 [Multi-domain] Cd Length: 30 Bit Score: 36.47 E-value: 1.99e-03
10 20
....*....|....*....|....*....
gi 767973872 79 GRSALHHAVHSGHLETVNLLLNKGASLNV 107
Cdd:pfam13606 2 GNTPLHLAARNGRLEIVKLLLENGADINA 30
|
|
| trp |
TIGR00870 |
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ... |
742-871 |
2.06e-03 |
|
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273311 [Multi-domain] Cd Length: 743 Bit Score: 41.99 E-value: 2.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 742 HEDCLELLLEHSPFSYLEGnpfTPLHCAVINNQDSTTEMLL-------GALGAKIVNSRDA----KGRTPLHAAAFADNV 810
Cdd:TIGR00870 65 NLELTELLLNLSCRGAVGD---TLLHAISLEYVDAVEAILLhllaafrKSGPLELANDQYTseftPGITALHLAAHRQNY 141
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767973872 811 SGLRMLLQHQAEVNA---------TDHT-----GRTALMTAAENGQTAAVEFLLYRGkADLTVLDENKNTALHLA 871
Cdd:TIGR00870 142 EIVKLLLERGASVPAracgdffvkSQGVdsfyhGESPLNAAACLGSPSIVALLSEDP-ADILTADSLGNTLLHLL 215
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
626-657 |
2.16e-03 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 36.50 E-value: 2.16e-03
10 20 30
....*....|....*....|....*....|...
gi 767973872 626 YGQTPLMLAI-MNGHVDCVHLLLEKGSTADAAD 657
Cdd:pfam00023 1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARD 33
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
849-907 |
2.35e-03 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 36.94 E-value: 2.35e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 767973872 849 LLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDlglINATNSALQMPLHIA 907
Cdd:pfam13857 1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVD---LNLKDEEGLTALDLA 56
|
|
| Ank_3 |
pfam13606 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
144-173 |
2.40e-03 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.
Pssm-ID: 463933 [Multi-domain] Cd Length: 30 Bit Score: 36.47 E-value: 2.40e-03
10 20 30
....*....|....*....|....*....|
gi 767973872 144 KGYGLLHTAAASGQIEVVKYLLRMGAEIDE 173
Cdd:pfam13606 1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
395-445 |
2.47e-03 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 36.87 E-value: 2.47e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 767973872 395 GRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAE 445
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLK 51
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
178-232 |
2.47e-03 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 36.87 E-value: 2.47e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 767973872 178 GNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGAlCLELLV 232
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVE-VLKLLL 54
|
|
| PHA02716 |
PHA02716 |
CPXV016; CPX019; EVM010; Provisional |
125-215 |
2.71e-03 |
|
CPXV016; CPX019; EVM010; Provisional
Pssm-ID: 165089 [Multi-domain] Cd Length: 764 Bit Score: 41.82 E-value: 2.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 125 LEVLKLLVARGADLGCKDRKGYGLLHTAAASGQI--EVVKYLLRMGAEIDEPNAFGNTALHIacYLGQDAVA-------- 194
Cdd:PHA02716 297 ISVVYSFLQPGVKLHYKDSAGRTCLHQYILRHNIstDIIKLLHEYGNDLNEPDNIGNTVLHT--YLSMLSVVnildpetd 374
|
90 100
....*....|....*....|....*....
gi 767973872 195 ----IE----LVNAGANVNQPNDKGFTPL 215
Cdd:PHA02716 375 ndirLDviqcLISLGADITAVNCLGYTPL 403
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
2-65 |
2.94e-03 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 41.42 E-value: 2.94e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767973872 2 SGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEAL 65
Cdd:PTZ00322 104 GGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167
|
|
| PHA02884 |
PHA02884 |
ankyrin repeat protein; Provisional |
148-252 |
3.78e-03 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165212 [Multi-domain] Cd Length: 300 Bit Score: 40.74 E-value: 3.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 148 LLHTAAASGQIEVVKYLLRMGAEIDEP-----NAFGNTALHIACYLGQDAvAIELVNAGANVNQ-PNDKGFTPLHVAAVS 221
Cdd:PHA02884 36 ILYSSIKFHYTDIIDAILKLGADPEAPfplseNSKTNPLIYAIDCDNDDA-AKLLIRYGADVNRyAEEAKITPLYISVLH 114
|
90 100 110
....*....|....*....|....*....|.
gi 767973872 222 TNGAlCLELLVNNGADVNYQSKEGKSPLHMA 252
Cdd:PHA02884 115 GCLK-CLEILLSYGADINIQTNDMVTPIELA 144
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
593-660 |
3.80e-03 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 41.04 E-value: 3.80e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767973872 593 TPLHAAAASGHTDSLHLLIDSGerADITdVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRG 660
Cdd:PTZ00322 117 TPLHIACANGHVQVVRVLLEFG--ADPT-LLDKDGKTPLELAEENGFREVVQLLSRHSQCHFELGANA 181
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
497-579 |
3.80e-03 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 41.04 E-value: 3.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 497 AAYGNRQNLELLLE--MSFNCLEDVESTipvsPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVE 574
Cdd:PTZ00322 90 AASGDAVGARILLTggADPNCRDYDGRT----PLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQ 165
|
....*
gi 767973872 575 VLTAH 579
Cdd:PTZ00322 166 LLSRH 170
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
395-423 |
3.87e-03 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 35.64 E-value: 3.87e-03
10 20
....*....|....*....|....*....
gi 767973872 395 GRTPLHYAAANGSYQCAVTLVTAGAGVNE 423
Cdd:smart00248 2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
|
|
| TRPV1 |
cd22196 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 ... |
548-665 |
4.09e-03 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 (TRPV1), a capsaicin (vanilloid) receptor, is the founding member of the vanilloid TRP subfamily (TRPV). In humans, it is expressed in the brain, kidney, pancreas, testis, uterus, spleen, stomach, small intestine, lung and liver. TRPV1 has been implicated to have function in thermo-sensation (heat), autonomic thermoregulation, nociception, food intake regulation, and multiple functions in the gastrointestinal (GI) tract. The receptor has also been involved in growth cone guidance, long-term depression, endocannabinoid signaling and osmosensing in the central nervous system. TRPV1 is up regulated in several human pathological conditions including vulvodynia, GI inflammation, Crohn's disease and ulcerative colitis. TRPV1 knock-out mice exhibit impaired sensation to thermal-mechanical acute pain. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.
Pssm-ID: 411980 [Multi-domain] Cd Length: 649 Bit Score: 40.94 E-value: 4.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 548 VNLDVRD--HKGRTALFLATERGSTECVEVLTAHGASalikerkrkwtpLHAAAasghtdslhllidSGERADITDVMDA 625
Cdd:cd22196 83 VNAAYTDsyYKGQTALHIAIERRNMHLVELLVQNGAD------------VHARA-------------SGEFFKKKKGGPG 137
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 767973872 626 --YGQTPLMLAIMNGHVDCVHLLLE---KGSTADAADLRGRTALH 665
Cdd:cd22196 138 fyFGELPLSLAACTNQLDIVKFLLEnphSPADISARDSMGNTVLH 182
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
489-543 |
4.12e-03 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 36.48 E-value: 4.12e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 767973872 489 GYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPvsPLHLAAYNGHCEALKTL 543
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGET--ALHFAASNGNVEVLKLL 53
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
796-828 |
4.34e-03 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 35.73 E-value: 4.34e-03
10 20 30
....*....|....*....|....*....|....
gi 767973872 796 KGRTPLHAAA-FADNVSGLRMLLQHQAEVNATDH 828
Cdd:pfam00023 1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
|
|
| PHA02716 |
PHA02716 |
CPXV016; CPX019; EVM010; Provisional |
2-182 |
4.41e-03 |
|
CPXV016; CPX019; EVM010; Provisional
Pssm-ID: 165089 [Multi-domain] Cd Length: 764 Bit Score: 41.05 E-value: 4.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 2 SGANVNAKDTLWLTPLHRAAASRN--EKVLGLLLAHSADVNARDKLWQTPLHVAAANratkcAEALAPLLSSLNVADRSG 79
Cdd:PHA02716 201 NGVNVNLQNNHLITPLHTYLITGNvcASVIKKIIELGGDMDMKCVNGMSPIMTYIIN-----IDNINPEITNIYIESLDG 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 80 RSA------LHHAVHSGH---LETVNLLLNKGASLNVCDKKERQPLHwAAFLGH---LEVLKLLVARGADLGCKDRKGYG 147
Cdd:PHA02716 276 NKVknipmiLHSYITLARnidISVVYSFLQPGVKLHYKDSAGRTCLH-QYILRHnisTDIIKLLHEYGNDLNEPDNIGNT 354
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 767973872 148 LLHTAAA--------------SGQIEVVKYLLRMGAEIDEPNAFGNTAL 182
Cdd:PHA02716 355 VLHTYLSmlsvvnildpetdnDIRLDVIQCLISLGADITAVNCLGYTPL 403
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
730-754 |
4.95e-03 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 35.64 E-value: 4.95e-03
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
71-119 |
5.33e-03 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 36.17 E-value: 5.33e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 767973872 71 SLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWA 119
Cdd:pfam13857 8 DLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
115-143 |
6.01e-03 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 35.34 E-value: 6.01e-03
10 20 30
....*....|....*....|....*....|
gi 767973872 115 PLHWAA-FLGHLEVLKLLVARGADLGCKDR 143
Cdd:pfam00023 5 PLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
15-44 |
7.11e-03 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 34.96 E-value: 7.11e-03
10 20 30
....*....|....*....|....*....|.
gi 767973872 15 TPLHRAAASR-NEKVLGLLLAHSADVNARDK 44
Cdd:pfam00023 4 TPLHLAAGRRgNLEIVKLLLSKGADVNARDK 34
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
174-218 |
7.38e-03 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 35.79 E-value: 7.38e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 767973872 174 PNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVA 218
Cdd:pfam13857 12 LDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
178-209 |
8.91e-03 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 34.96 E-value: 8.91e-03
10 20 30
....*....|....*....|....*....|...
gi 767973872 178 GNTALHIACY-LGQDAVAIELVNAGANVNQPND 209
Cdd:pfam00023 2 GNTPLHLAAGrRGNLEIVKLLLSKGADVNARDK 34
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
278-303 |
9.21e-03 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 34.87 E-value: 9.21e-03
|
| PHA02736 |
PHA02736 |
Viral ankyrin protein; Provisional |
362-411 |
9.52e-03 |
|
Viral ankyrin protein; Provisional
Pssm-ID: 165103 [Multi-domain] Cd Length: 154 Bit Score: 37.93 E-value: 9.52e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 767973872 362 GRTCLHAAASGGNV---ECLNLLLSSGADLRRRD-KFGRTPLHYAAANGSYQCA 411
Cdd:PHA02736 55 GKQCVHIVSNPDKAdpqEKLKLLMEWGADINGKErVFGNTPLHIAVYTQNYELA 108
|
|
| TRPV1 |
cd22196 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 ... |
796-869 |
9.52e-03 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 (TRPV1), a capsaicin (vanilloid) receptor, is the founding member of the vanilloid TRP subfamily (TRPV). In humans, it is expressed in the brain, kidney, pancreas, testis, uterus, spleen, stomach, small intestine, lung and liver. TRPV1 has been implicated to have function in thermo-sensation (heat), autonomic thermoregulation, nociception, food intake regulation, and multiple functions in the gastrointestinal (GI) tract. The receptor has also been involved in growth cone guidance, long-term depression, endocannabinoid signaling and osmosensing in the central nervous system. TRPV1 is up regulated in several human pathological conditions including vulvodynia, GI inflammation, Crohn's disease and ulcerative colitis. TRPV1 knock-out mice exhibit impaired sensation to thermal-mechanical acute pain. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.
Pssm-ID: 411980 [Multi-domain] Cd Length: 649 Bit Score: 39.79 E-value: 9.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973872 796 KGRTPLHAAAFADNVSGLRMLLQHQAEVNATD--------------HTGRTALMTAAENGQTAAVEFLLYR--GKADLTV 859
Cdd:cd22196 93 KGQTALHIAIERRNMHLVELLVQNGADVHARAsgeffkkkkggpgfYFGELPLSLAACTNQLDIVKFLLENphSPADISA 172
|
90
....*....|
gi 767973872 860 LDENKNTALH 869
Cdd:cd22196 173 RDSMGNTVLH 182
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
904-957 |
9.84e-03 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 36.25 E-value: 9.84e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 767973872 904 LHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACApNKDVADCLALILSTM 957
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAA-KNGHLEIVKLLLEHA 53
|
|
| |
