NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|767963601|ref|XP_011538395|]
View 

palmitoyltransferase ZDHHC6 isoform X8 [Homo sapiens]

Protein Classification

SH3 domain-containing protein( domain architecture ID 99303)

Src Homology 3 (SH3) domain-containing protein plays versatile and diverse roles in the cell, including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies, among others

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
SH3 super family cl17036
Src Homology 3 domain superfamily; Src Homology 3 (SH3) domains are protein interaction ...
 213-292 1.56e-03

Src Homology 3 domain superfamily; Src Homology 3 (SH3) domains are protein interaction domains that bind proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs. Thus, they are referred to as proline-recognition domains (PRDs). SH3 domains are less selective and show more diverse specificity compared to other PRDs. They have been shown to bind peptide sequences that lack the PxxP motif; examples include the PxxDY motif of Eps8 and the RKxxYxxY sequence in SKAP55. SH3 domain containing proteins play versatile and diverse roles in the cell, including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies, among others. Many members of this superfamily are adaptor proteins that associate with a number of protein partners, facilitating complex formation and signal transduction.


The actual alignment was detected with superfamily member pfam07653:

Pssm-ID: 473055 [Multi-domain]  Cd Length: 54  Bit Score: 36.03  E-value: 1.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963601  213 RYKVIEDYSGACCPLnkgiktfftspcteeprIQLQKGEFILATRGLrywlygdkilDDSFIEG-VSRIRGWFPRKCVEK 291
Cdd:pfam07653   1 YGRVIFDYVGTDKNG-----------------LTLKKGDVVKVLGKD----------NDGWWEGeTGGRVGLVPSTAVEE 53


                  .
gi 767963601  292 C 292
Cdd:pfam07653  54 I 54
 
Name Accession Description Interval E-value
SH3_2 pfam07653
Variant SH3 domain; SH3 (Src homology 3) domains are often indicative of a protein involved in ...
 213-292 1.56e-03

Variant SH3 domain; SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organization. First described in the Src cytoplasmic tyrosine kinase. The structure is a partly opened beta barrel.


Pssm-ID: 429575 [Multi-domain]  Cd Length: 54  Bit Score: 36.03  E-value: 1.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963601  213 RYKVIEDYSGACCPLnkgiktfftspcteeprIQLQKGEFILATRGLrywlygdkilDDSFIEG-VSRIRGWFPRKCVEK 291
Cdd:pfam07653   1 YGRVIFDYVGTDKNG-----------------LTLKKGDVVKVLGKD----------NDGWWEGeTGGRVGLVPSTAVEE 53


                  .
gi 767963601  292 C 292
Cdd:pfam07653  54 I 54
 
Name Accession Description Interval E-value
SH3_2 pfam07653
Variant SH3 domain; SH3 (Src homology 3) domains are often indicative of a protein involved in ...
 213-292 1.56e-03

Variant SH3 domain; SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organization. First described in the Src cytoplasmic tyrosine kinase. The structure is a partly opened beta barrel.


Pssm-ID: 429575 [Multi-domain]  Cd Length: 54  Bit Score: 36.03  E-value: 1.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963601  213 RYKVIEDYSGACCPLnkgiktfftspcteeprIQLQKGEFILATRGLrywlygdkilDDSFIEG-VSRIRGWFPRKCVEK 291
Cdd:pfam07653   1 YGRVIFDYVGTDKNG-----------------LTLKKGDVVKVLGKD----------NDGWWEGeTGGRVGLVPSTAVEE 53


                  .
gi 767963601  292 C 292
Cdd:pfam07653  54 I 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH