|
Name |
Accession |
Description |
Interval |
E-value |
| COG5028 |
COG5028 |
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking ... |
323-1113 |
1.32e-168 |
|
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion];
Pssm-ID: 227361 [Multi-domain] Cd Length: 861 Bit Score: 518.96 E-value: 1.32e-168
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 323 PDAIPSPQLSELPPQQKTRHRIDPDAIPS-PIQVIEDdrnnrgTEPFVTGVRG----QVPPLvTTNFLVKDQGNASPRYI 397
Cdd:COG5028 81 PAFQSQQKFSSPYGGSMADGTAPKPTNPLvPVDLFED------QPPPISDLFLppppIVPPL-TTNFVGSEQSNCSPKYV 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 398 RCTSYNIPCTSDMAKQAQVPLAAVIKPLARLPPEEASPYVVDHGEsgPLRCNRCKAYMCPFMQFIEGGRRFQCCFCSCIN 477
Cdd:COG5028 154 RSTMYAIPETNDLLKKSKIPFGLVIRPFLELYPEEDPVPLVEDGS--IVRCRRCRSYINPFVQFIEQGRKWRCNICRSKN 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 478 DVPPQYFQHLDHTGKRVDAYDRPELSLGSYEFLATVDYckNNKFPSPPAFIFMIDVSYNAIRTGLV----RLLCEELKSL 553
Cdd:COG5028 232 DVPEGFDNPSGPNDPRSDRYSRPELKSGVVDFLAPKEY--SLRQPPPPVYVFLIDVSFEAIKNGLVkaaiRAILENLDQI 309
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 554 LDFLPReggaeesaIRVGFVTYNKVLHFYNVKSSLaQPQMMVVSDVADMFVPLLDG-FLVNVNESRAVITSLLDQIPEMF 632
Cdd:COG5028 310 PNFDPR--------TKIAIICFDSSLHFFKLSPDL-DEQMLIVSDLDEPFLPFPSGlFVLPLKSCKQIIETLLDRVPRIF 380
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 633 ADTRETETVFVPviqagmeALKAA-----ECAGKLFLFHTSLPIAeAPGKLKNRDDrklintdKEKTLFQPQTGAYQTLA 707
Cdd:COG5028 381 QDNKSPKNALGP-------ALKAAksligGTGGKIIVFLSTLPNM-GIGKLQLRED-------KESSLLSCKDSFYKEFA 445
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 708 KECVAQGCCVDLFLFPNQYVDVATLSVVPQLTGGSVYKYASFQVE--NDQERFLSDLRRDVQKVVGFDAVMRVRTSTGIR 785
Cdd:COG5028 446 IECSKVGISVDLFLTSEDYIDVATLSHLCRYTGGQTYFYPNFSATrpNDATKLANDLVSHLSMEIGYEAVMRVRCSTGLR 525
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 786 AVDFFGAFYMSNTTDVELAGLDGDKTVTVEFKHDDRLNEeSGALLQCALLYTSCAGQRRLRIHNLALNCCTQLADLYRNC 865
Cdd:COG5028 526 VSSFYGNFFNRSSDLCAFSTMPRDTSLLVEFSIDEKLMT-SDVYFQVALLYTLNDGERRIRVVNLSLPTSSSIREVYASA 604
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 866 ETDTLINYMAKFAYRGVLNSPVKAVRDTLITQCAQILACYRKNCASPSSAGQLILPECMKLLPVYLNCVLKSDVLQPGAe 945
Cdd:COG5028 605 DQLAIACILAKKASTKALNSSLKEARVLINKSMVDILKAYKKELVKSNTSTQLPLPANLKLLPLLMLALLKSSAFRSGS- 683
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 946 VTTDDRAYVRQLVTSMDVTETNVFFYPRLLPLTKSPVES-------TTEPPAVRASEERLSNGDIYLLENGLNLFLWVGA 1018
Cdd:COG5028 684 TPSDIRISALNRLTSLPLKQLMRNIYPTLYALHDMPIEAglpdeglLVLPSPINATSSLLESGGLYLIDTGQKIFLWFGK 763
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 1019 SVQQGVVQSLFSVSSFSQITSGLSVLPVLDNPLSKKVRGLIDSLRaQRSRYMKLTVVKQED----KMEMLFKHFLVEDKS 1094
Cdd:COG5028 764 DAVPSLLQDLFGVDSLSDIPSGKFTLPPTGNEFNERVRNIIGELR-SVNDDSTLPLVLVRGggdpSLRLWFFSTLVEDKT 842
|
810
....*....|....*....
gi 767964335 1095 LsGGASYVDFLCHMHKEIR 1113
Cdd:COG5028 843 L-NIPSYLDYLQILHEKIK 860
|
|
| Sec24-like |
cd01479 |
Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the ... |
522-781 |
7.53e-124 |
|
Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes of vesicular carriers within the endocytic and the biosynthetic pathways are COP- and clathrin-coated vesicles. Formation of COPII vesicles requires the ordered assembly of the coat built from several cytosolic components GTPase Sar1, complexes of Sec23-Sec24 and Sec13-Sec31. The process is initiated by the conversion of GDP to GTP by the GTPase Sar1 which then recruits the heterodimeric complex of Sec23 and Sec24. This heterodimeric complex generates the pre-budding complex. The final step leading to membrane deformation and budding of COPII-coated vesicles is carried by the heterodimeric complex Sec13-Sec31. The members of this CD belong to the Sec23-like family. Sec 24 is very similar to Sec23. The Sec23 and Sec24 polypeptides fold into five distinct domains: a beta-barrel, a zinc finger, a vWA or trunk, an all helical region and a carboxy Gelsolin domain. The members of this subgroup carry a partial MIDAS motif and have the overall Para-Rossmann type fold that is characteristic of this superfamily.
Pssm-ID: 238756 [Multi-domain] Cd Length: 244 Bit Score: 379.31 E-value: 7.53e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 522 PSPPAFIFMIDVSYNAIRTGLVRLLCEELKSLLDFLPREggaeESAIRVGFVTYNKVLHFYNVKSSLAQPQMMVVSDVAD 601
Cdd:cd01479 1 PQPAVYVFLIDVSYNAIKSGLLATACEALLSNLDNLPGD----DPRTRVGFITFDSTLHFFNLKSSLEQPQMMVVSDLDD 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 602 MFVPLLDGFLVNVNESRAVITSLLDQIPEMFADTRETETVFVPVIQAGMEALKaaECAGKLFLFHTSLPIAEApGKLKNR 681
Cdd:cd01479 77 PFLPLPDGLLVNLKESRQVIEDLLDQIPEMFQDTKETESALGPALQAAFLLLK--ETGGKIIVFQSSLPTLGA-GKLKSR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 682 DDRKLINTDKEKTLFQPQTGAYQTLAKECVAQGCCVDLFLFPNQYVDVATLSVVPQLTGGSVYKYASFQvendqerflSD 761
Cdd:cd01479 154 EDPKLLSTDKEKQLLQPQTDFYKKLALECVKSQISVDLFLFSNQYVDVATLGCLSRLTGGQVYYYPSFN---------FS 224
|
250 260
....*....|....*....|
gi 767964335 762 LRRDVQKVVGFDAVMRVRTS 781
Cdd:cd01479 225 APNDVEKLVNELARYLTRKI 244
|
|
| Sec23_trunk |
pfam04811 |
Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum ... |
522-766 |
4.48e-116 |
|
Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface.
Pssm-ID: 398467 [Multi-domain] Cd Length: 241 Bit Score: 358.49 E-value: 4.48e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 522 PSPPAFIFMIDVSYNAIRTGLVRLLCEELKSLLDFLPREggaeeSAIRVGFVTYNKVLHFYNVKSSLAQPQMMVVSDVAD 601
Cdd:pfam04811 1 PQPPVFLFVIDVSYNAIKSGLLAALKESLLQSLDLLPGD-----PRARVGFITFDSTVHFFNLGSSLRQPQMLVVSDLQD 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 602 MFVPLLDGFLVNVNESRAVITSLLDQIPEMFADTRETETVFVPVIQAGMEALKAAECAGKLFLFHTSLPIAEAPGKLKNR 681
Cdd:pfam04811 76 MFLPLPDRFLVPLSECRFVLEDLLEQLPPMFPVTKRPERCLGPALQAAFLLLKAAFTGGKIMVFQGGLPTVGPGGKLKSR 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 682 DDRKLINTDKEKTLFQPQT-GAYQTLAKECVAQGCCVDLFLFPNQYVDVATLSVVPQLTGGSVYKYASFQVENDQERFLS 760
Cdd:pfam04811 156 LDESHHGTDKEKAKLVKKAdKFYKSLAKECVKQGHSVDLFAFSLDYVDVATLGQLSRLTGGQVYLYPSFQADVDGSKFKQ 235
|
....*.
gi 767964335 761 DLRRDV 766
Cdd:pfam04811 236 DLQRYF 241
|
|
| trunk_domain |
cd01468 |
trunk domain. COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi ... |
522-764 |
4.53e-104 |
|
trunk domain. COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface. Some members of this family possess a partial MIDAS motif that is a characteristic feature of most vWA domain proteins.
Pssm-ID: 238745 [Multi-domain] Cd Length: 239 Bit Score: 326.51 E-value: 4.53e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 522 PSPPAFIFMIDVSYNAIRTGLVRLLCEELKSLLDFLPREGGAeesaiRVGFVTYNKVLHFYNVKSSLAQPQMMVVSDVAD 601
Cdd:cd01468 1 PQPPVFVFVIDVSYEAIKEGLLQALKESLLASLDLLPGDPRA-----RVGLITYDSTVHFYNLSSDLAQPKMYVVSDLKD 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 602 MFVPLLDGFLVNVNESRAVITSLLDQIPEMFAD--TRETETVFVPVIQAGMEALKAAECAGKLFLFHTSLPIAEaPGKLK 679
Cdd:cd01468 76 VFLPLPDRFLVPLSECKKVIHDLLEQLPPMFWPvpTHRPERCLGPALQAAFLLLKGTFAGGRIIVFQGGLPTVG-PGKLK 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 680 NRDDRKLINTDKEKTLFQPQTGAYQTLAKECVAQGCCVDLFLFPNQYVDVATLSVVPQLTGGSVYKYASFQVENDQERFL 759
Cdd:cd01468 155 SREDKEPIRSHDEAQLLKPATKFYKSLAKECVKSGICVDLFAFSLDYVDVATLKQLAKSTGGQVYLYDSFQAPNDGSKFK 234
|
....*
gi 767964335 760 SDLRR 764
Cdd:cd01468 235 QDLQR 239
|
|
| PTZ00395 |
PTZ00395 |
Sec24-related protein; Provisional |
19-1114 |
4.02e-48 |
|
Sec24-related protein; Provisional
Pssm-ID: 185594 [Multi-domain] Cd Length: 1560 Bit Score: 187.97 E-value: 4.02e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 19 IYPGYHqssyGGQSGSTAPAIPYGAYNGPVPGYQQTPPQGMSRAPPSSGapPASTAQAPCgqAAYGQFGQgdvQNGPSST 98
Cdd:PTZ00395 338 IYGGFH----DGSPNAASAGAPFNGLGNQADGGHINQVHPDARGAWAGG--PHSNASYNC--AAYSNAAQ---SNAAQSN 406
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 99 VQMQRLPGSQPfGSPLAPVGNQPPVLQPYGPPPTSAqvaTQLSGmqisgavapaPPSSGlgfgPPTSlasasgSFPNSGL 178
Cdd:PTZ00395 407 AGFSNAGYSNP-GNSNPGYNNAPNSNTPYNNPPNSN---TPYSN----------PPNSN----PPYS------NLPYSNT 462
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 179 -YGSYPQGQAPPLSQAQGHPGIQTP-QRSAPSQASSFTPPASGGPRLPSMTGPllpGQSFGGPSVSQPnhvssppqalpp 256
Cdd:PTZ00395 463 pYSNAPLSNAPPSSAKDHHSAYHAAyQHRAANQPAANLPTANQPAANNFHGAA---GNSVGNPFASRP------------ 527
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 257 gtqmtgplgplppmhspqqpgyqpqqngsFG--PARGPQSNYGGPYPAAPTFGSQPGPPQPLPPKRLDPDAIPSPQlSEL 334
Cdd:PTZ00395 528 -----------------------------FGsaPYGGNAATTADPNGIAKREDHPEGGTNRQKYEQSDEESVESSS-SEN 577
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 335 PPQ----------------QKTRHRIDPDAIPSPIQVIEDDRNNRGTEPFVTgVRGQVPPLVTTNFLVKDQGNASPRYIR 398
Cdd:PTZ00395 578 SSEnenevtdkgeeiysllKKTINRIDMNKIPRPIINTQEKKKKKNLKVFET-CKYISPPSYYQPYISIDTGKADPRFLK 656
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 399 CTSYNIPCTSDMAKQAQVPLAAVIKPLARLPPEEASPYV-----VDHGESGP--LRCNRCKAYM-CPFMQFIEGGrrFQC 470
Cdd:PTZ00395 657 STLYQIPLFSETLKLSQIPFGIIVNPFACLNEGEGIDKIdmkdiINDKEENIeiLRCPKCLGYLhATILEDISSS--VQC 734
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 471 CFCSC---IND--------------------------------------VPPQYFQHLD-------HTGKRV-------- 494
Cdd:PTZ00395 735 VFCDTdflINEnvlfdifqynekighkesdhnehgnslspllkgsvdiiIPPIYYHNVNkfkltytYLNKNInqtafmit 814
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 495 --------------------------------DAYDRPELSLGSY----------------------------------- 507
Cdd:PTZ00395 815 nkimsftkhisnslvandskggnkatsasafgDSGDANFLAGGGYtnyggaggyntydnqsgynnhdvvnnrggsgagnh 894
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 508 ---------EFLATVD------------YCKNN---------------KFPS-----PPAFIFMIDVSYNAIRTGLVRLL 546
Cdd:PTZ00395 895 lygkdhdvqNFDNVMDnanftihdmknlICEKNgepdsakirrnsflaKYPQvknmlPPYFVFVVECSYNAIYNNITYTI 974
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 547 CEELKSLLDFL--PReggaeesaIRVGFVTYNKVLHFYNVKSSLAQP-------------QMMVVSDVADMFVPL-LDGF 610
Cdd:PTZ00395 975 LEGIRYAVQNVkcPQ--------TKIAIITFNSSIYFYHCKGGKGVSgeegdggggsgnhQVIVMSDVDDPFLPLpLEDL 1046
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 611 LVNVNESRAVITSLLDQIPEMFADTRETETVFVPVIQAGMEALKAAECAGKLFLFHTSLPIAeAPGKLKnrddrKLINTD 690
Cdd:PTZ00395 1047 FFGCVEEIDKINTLIDTIKSVSTTMQSYGSCGNSALKIAMDMLKERNGLGSICMFYTTTPNC-GIGAIK-----ELKKDL 1120
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 691 KEKTLFQPQTGAYQTLAKECVAQGCCVDLFLFP--NQYVDVATLSVVPQLTGGSVYKYASFQVEND-QERFLSDLRRDVQ 767
Cdd:PTZ00395 1121 QENFLEVKQKIFYDSLLLDLYAFNISVDIFIISsnNVRVCVPSLQYVAQNTGGKILFVENFLWQKDyKEIYMNIMDTLTS 1200
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 768 KVVGFDAVMRVRTSTGIRAVDFFGAFYMSNTT----DVELAGLDGDKTVTVEFKHDDRLNEESGALLQCALLYTSCAGQR 843
Cdd:PTZ00395 1201 EDIAYCCELKLRYSHHMSVKKLFCCNNNFNSIisvdTIKIPKIRHDQTFAFLLNYSDISESKKQIYFQCACIYTNLWGDR 1280
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 844 RLRIHNLALNCCTQLADLYRNCETDTLINYMAKFAYRGVLNSpvKAVRDTLITQCAQILACYRKNCASPSSAGQLILPEC 923
Cdd:PTZ00395 1281 FVRLHTTHMNLTSSLSTVFRYTDAEALMNILIKQLCTNILHN--DNYSKIIIDNLAAILFSYRINCASSAHSGQLILPDT 1358
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 924 MKLLPVYLNCVLKSDVLQpgAEVTTDDRAYVRQLVTSMDVTETNVFFYPRLLPL----TKSPVESTTE------PPAVRA 993
Cdd:PTZ00395 1359 LKLLPLFTSSLLKHNVTK--KEILHDLKVYSLIKLLSMPIISSLLYVYPVMYVIhikgKTNEIDSMDVdddlfiPKTIPS 1436
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 994 SEERLSNGDIYLLENGLNLFLWVG----ASVQQGVVQSLFSVSSFSQitsglsvLPVLDNPLSKKVRGLIDSLRA--QRS 1067
Cdd:PTZ00395 1437 SAEKIYSNGIYLLDACTHFYLYFGfhsdANFAKEIVGDIPTEKNAHE-------LNLTDTPNAQKVQRIIKNLSRihHFN 1509
|
1290 1300 1310 1320
....*....|....*....|....*....|....*....|....*..
gi 767964335 1068 RYMKLTVVKQEDKMEMLFKHFLVEDKSlSGGASYVDFLCHMHKEIRQ 1114
Cdd:PTZ00395 1510 KYVPLVMVAPKSNEEEHLISLCVEDKA-DKEYSYVNFLCFIHKLVHK 1555
|
|
| Sec23_helical |
pfam04815 |
Sec23/Sec24 helical domain; COPII-coated vesicles carry proteins from the endoplasmic ... |
868-966 |
1.58e-34 |
|
Sec23/Sec24 helical domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is composed of five alpha helices.
Pssm-ID: 461441 [Multi-domain] Cd Length: 103 Bit Score: 127.62 E-value: 1.58e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 868 DTLINYMAKFAYRGVLNSPVKAVRDTLITQCAQILACYRKNCASPSSAGQLILPECMKLLPVYLNCVLKSDVLQPGAEVT 947
Cdd:pfam04815 3 EAIAVLLAKKAVEKALSSSLSDAREALDNKLVDILAAYRKYCASSSSPGQLILPESLKLLPLYMLALLKSPALRGGNSSP 82
|
90
....*....|....*....
gi 767964335 948 TDDRAYVRQLVTSMDVTET 966
Cdd:pfam04815 83 SDERAYARHLLLSLPVEEL 101
|
|
| Sec23_BS |
pfam08033 |
Sec23/Sec24 beta-sandwich domain; |
771-854 |
3.70e-28 |
|
Sec23/Sec24 beta-sandwich domain;
Pssm-ID: 429794 [Multi-domain] Cd Length: 86 Bit Score: 108.78 E-value: 3.70e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 771 GFDAVMRVRTSTGIRAVDFFGAFYMSNTTD-VELAGLDGDKTVTVEFKHDDRLNEESGALLQCALLYTSCAGQRRLRIHN 849
Cdd:pfam08033 1 GFNAVLRVRTSKGLKVSGFIGNFVSRSSGDtWKLPSLDPDTSYAFEFDIDEPLPNGSNAYIQFALLYTHSSGERRIRVTT 80
|
....*
gi 767964335 850 LALNC 854
Cdd:pfam08033 81 VALPV 85
|
|
| PLN00162 |
PLN00162 |
transport protein sec23; Provisional |
401-847 |
1.07e-18 |
|
transport protein sec23; Provisional
Pssm-ID: 215083 [Multi-domain] Cd Length: 761 Bit Score: 91.93 E-value: 1.07e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 401 SYNI-PCTSDMAKQAQVPLAAVIKPLARLPPEEASPYvvdhgesGPLRCNRCKAYMCPFMQFIEGGRRFQCCFCSCINDV 479
Cdd:PLN00162 15 SWNVwPSSKIEASKCVIPLAALYTPLKPLPELPVLPY-------DPLRCRTCRAVLNPYCRVDFQAKIWICPFCFQRNHF 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 480 PPQYF----QHLDhtgkrvdaydrPELslgsYEFLATVDY---CKNNKFPSPPAFIFMIDVSynAIRTGLvRLLCEELKS 552
Cdd:PLN00162 88 PPHYSsiseTNLP-----------AEL----FPQYTTVEYtlpPGSGGAPSPPVFVFVVDTC--MIEEEL-GALKSALLQ 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 553 LLDFLPreggaeESAiRVGFVTY----------------------------NKVLHFYNVKSSLAQPQMMVVSDVADMFV 604
Cdd:PLN00162 150 AIALLP------ENA-LVGLITFgthvhvhelgfsecsksyvfrgnkevskDQILEQLGLGGKKRRPAGGGIAGARDGLS 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 605 PL-LDGFLVNVNESRAVITSLLDQI-PEMF---ADTRETETVFVPV-IQAGMEALKAAECAGKLFLFhTSLPIAEAPGKL 678
Cdd:PLN00162 223 SSgVNRFLLPASECEFTLNSALEELqKDPWpvpPGHRPARCTGAALsVAAGLLGACVPGTGARIMAF-VGGPCTEGPGAI 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 679 KNRDDRKLINTDKE-----KTLFQPQTGAYQTLAKECVAQGCCVDLFLFPNQYVDVATLSVVPQLTGGSVYKYASFqven 753
Cdd:PLN00162 302 VSKDLSEPIRSHKDldkdaAPYYKKAVKFYEGLAKQLVAQGHVLDVFACSLDQVGVAEMKVAVERTGGLVVLAESF---- 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 754 DQERFLSDLRRDVQKV------VGFDAVMRVRTSTGIRAVDFFG---------------AFYMSNTTDVELAGLDGDKTV 812
Cdd:PLN00162 378 GHSVFKDSLRRVFERDgegslgLSFNGTFEVNCSKDVKVQGAIGpcaslekkgpsvsdtEIGEGGTTAWKLCGLDKKTSL 457
|
490 500 510 520
....*....|....*....|....*....|....*....|
gi 767964335 813 TVEF----KHDDRLNEESGAL-LQCALLYTSCAGQRRLRI 847
Cdd:PLN00162 458 AVFFevanSGQSNPQPPGQQFfLQFLTRYQHSNGQTRLRV 497
|
|
| zf-Sec23_Sec24 |
pfam04810 |
Sec23/Sec24 zinc finger; COPII-coated vesicles carry proteins from the endoplasmic reticulum ... |
445-482 |
3.51e-17 |
|
Sec23/Sec24 zinc finger; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is found to be zinc binding domain.
Pssm-ID: 461437 [Multi-domain] Cd Length: 38 Bit Score: 75.95 E-value: 3.51e-17
10 20 30
....*....|....*....|....*....|....*...
gi 767964335 445 PLRCNRCKAYMCPFMQFIEGGRRFQCCFCSCINDVPPQ 482
Cdd:pfam04810 1 PVRCRRCRAYLNPFCQFDFGGKKWTCNFCGTRNPVPPE 38
|
|
| SEC23 |
COG5047 |
Vesicle coat complex COPII, subunit SEC23 [Intracellular trafficking and secretion]; |
397-974 |
1.15e-16 |
|
Vesicle coat complex COPII, subunit SEC23 [Intracellular trafficking and secretion];
Pssm-ID: 227380 [Multi-domain] Cd Length: 755 Bit Score: 85.32 E-value: 1.15e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 397 IRCTSYNIPCTSDMAKQAQVPLAAVIKPLARLPPEEASPYvvdhgesGPLRCNR-CKAYMCPFMQFIEGGRRFQCCFCSC 475
Cdd:COG5047 12 IRLTWNVFPATRGDATRTVIPIACLYTPLHEDDALTVNYY-------EPVKCTApCKAVLNPYCHIDERNQSWICPFCNQ 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 476 INDVPPQYfqhldhtgkrvDAYDRPELSLGSYEFLATVDYCKNNKFPSPPAFIFMIDVSYNAIRtglVRLLCEELKSLLD 555
Cdd:COG5047 85 RNTLPPQY-----------RDISNANLPLELLPQSSTIEYTLSKPVILPPVFFFVVDACCDEEE---LTALKDSLIVSLS 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 556 FLPREggaeesAIrVGFVTYNKVLHFYNVkSSLAQPQMMVVSDVADMFVPLLD--------------------------- 608
Cdd:COG5047 151 LLPPE------AL-VGLITYGTSIQVHEL-NAENHRRSYVFSGNKEYTKENLQellalskptksggfeskisgigqfass 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 609 GFLVNVNESRAVITSLLDQI-------PEMFADTRETET-VFVPVIQAGMEALKaaeCAGKLFLFhTSLPIAEAPGKLKN 680
Cdd:COG5047 223 RFLLPTQQCEFKLLNILEQLqpdpwpvPAGKRPLRCTGSaLNIASSLLEQCFPN---AGCHIVLF-AGGPCTVGPGTVVS 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 681 RDDRK------LINTDKEKtLFQPQTGAYQTLAKECVAQGCCVDLFLFPNQYVDVATLSVVPQLTGGSVYKYASFQVEND 754
Cdd:COG5047 299 TELKEpmrshhDIESDSAQ-HSKKATKFYKGLAERVANQGHALDIFAGCLDQIGIMEMEPLTTSTGGALVLSDSFTTSIF 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 755 QERFLSDLRRDVQK--VVGFDAVMRVRTSTGIRAVDFFG---------------AFYMSNTTDVELAGLDGDKTVTVEFK 817
Cdd:COG5047 378 KQSFQRIFNRDSEGylKMGFNANMEVKTSKNLKIKGLIGhavsvkkkannisdsEIGIGATNSWKMASLSPKSNYALYFE 457
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 818 HDDRLNEESG-----ALLQCALLYTSCAGQRRLRIHNLALNCCTQLADL-YRNCETDTLINYMAKFAyrgVLNSPVKAVR 891
Cdd:COG5047 458 IALGAASGSAqrpaeAYIQFITTYQHSSGTYRIRVTTVARMFTDGGLPKiNRSFDQEAAAVFMARIA---AFKAETEDII 534
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 892 D-------TLITQCaQILACYRKNcaSPSSAGqliLPECMKLLPVYLNCVLKSDVLQPGAEvTTDDRAYVRQLVTSMDVT 964
Cdd:COG5047 535 DvfrwidrNLIRLC-QKFADYRKD--DPSSFR---LDPNFTLYPQFMYHLRRSPFLSVFNN-SPDETAFYRHMLNNADVN 607
|
650
....*....|
gi 767964335 965 ETNVFFYPRL 974
Cdd:COG5047 608 DSLIMIQPTL 617
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
4-378 |
4.20e-15 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 80.75 E-value: 4.20e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 4 NQSVPPVPPfgQPQPIYPGY----HQSSYGGQSGS-TAPAIPYGAYNGPVPGYQQTPPQGMSRAPPSSGAPPASTAQAPC 78
Cdd:PHA03247 2565 DRSVPPPRP--APRPSEPAVtsraRRPDAPPQSARpRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHP 2642
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 79 GQAAYGQFGQGDV-----------------QNGPSSTVQMQRLPGSQPFGSPLAPVGNQPPVLQPYGPPPTSAQVATQLS 141
Cdd:PHA03247 2643 PPTVPPPERPRDDpapgrvsrprrarrlgrAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLP 2722
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 142 -GMQISGAVAPAPPSSGLGFGPPTSLASASG-SFPNSGLYGSYPQGQAPPLSQAQGHPGIQTP---------QRSAPSQA 210
Cdd:PHA03247 2723 pGPAAARQASPALPAAPAPPAVPAGPATPGGpARPARPPTTAGPPAPAPPAAPAAGPPRRLTRpavaslsesRESLPSPW 2802
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 211 SSFTPPASGGPRLPSMTGPLLPGQSFGGPSVSQPNHVSSPPQALPPGTQMTGPLGPLPPMHSPQQPGYQPQQNGSfgPAR 290
Cdd:PHA03247 2803 DPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAA--PAR 2880
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 291 GPQSNYGGPYPAAPTFGSQPGPPQPLPPKRLDPDAIPSPQLSELPPQQKTRH-------------RIDPDAIPSPIQVIE 357
Cdd:PHA03247 2881 PPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPppppprpqpplapTTDPAGAGEPSGAVP 2960
|
410 420
....*....|....*....|.
gi 767964335 358 DDRNNRGTEPFVTGVRGQVPP 378
Cdd:PHA03247 2961 QPWLGALVPGRVAVPRFRVPQ 2981
|
|
| Gelsolin |
pfam00626 |
Gelsolin repeat; |
984-1059 |
2.80e-12 |
|
Gelsolin repeat;
Pssm-ID: 395501 [Multi-domain] Cd Length: 76 Bit Score: 63.10 E-value: 2.80e-12
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767964335 984 STTEPPAVRASEERLSNGDIYLLENGLNLFLWVGASVQQgvVQSLFSVSSFSQI-TSGLSVLPVLDN-PLSKKVRGLI 1059
Cdd:pfam00626 1 KFVLPPPVPLSQESLNSGDCYLLDNGFTIFLWVGKGSSL--LEKLFAALLAAQLdDDERFPLPEVIRvPQGKEPARFL 76
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
8-304 |
8.42e-12 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 69.97 E-value: 8.42e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 8 PPVPPFGQPQPIYPGYHQSSYGGQSGSTAPA-----IPYGAYNGPV----------PGYQQTPPQGMSRAPPSSGAPPAS 72
Cdd:PHA03247 2704 PPPTPEPAPHALVSATPLPPGPAAARQASPAlpaapAPPAVPAGPAtpggparparPPTTAGPPAPAPPAAPAAGPPRRL 2783
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 73 TAQAPCGQAAYGQFGQGDVQNGPSSTVQMQRLPGSQPFGSPLAPVgnqppvlqpygPPPTSAQvatqlsgmqisgavaPA 152
Cdd:PHA03247 2784 TRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPL-----------PPPTSAQ---------------PT 2837
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 153 PPSSGLGFgPPTSLASASGSFPNSGLYGSYPQGQAPPLSQAQGHPGIQTPQRSAPSQAS-SFTPPASGGPRLPSmtgPLL 231
Cdd:PHA03247 2838 APPPPPGP-PPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTeSFALPPDQPERPPQ---PQA 2913
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767964335 232 PGQSFGGPSVSQPNHVSSPPQAlPPGTQMTGPLGPLPPMHSPQQPGYQPQQNGSFGPARGPQSNYGGPYPAAP 304
Cdd:PHA03247 2914 PPPPQPQPQPPPPPQPQPPPPP-PPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPS 2985
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
6-271 |
3.12e-11 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 67.87 E-value: 3.12e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 6 SVPPVPPFGQPQPIYPGYHQSSYGGQSGSTAPAIPYGAYNGPVPgyqQTPPQGMSRAPPSSGAPPASTAQA--------- 76
Cdd:pfam03154 202 SAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSP---HPPLQPMTQPPPPSQVSPQPLPQPslhgqmppm 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 77 ----------------PCGQAAYGQFGQGDVQNGPSSTV-----QMQRLPGSQPFGSPLAPVGNQP----PVLQPY-GPP 130
Cdd:pfam03154 279 phslqtgpshmqhpvpPQPFPLTPQSSQSQVPPGPSPAApgqsqQRIHTPPSQSQLQSQQPPREQPlppaPLSMPHiKPP 358
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 131 PTS--AQVATQLSGMQISGAVAPAPPSSGLGFGPPTS---LASASGSFPNSG------LYGSYPQGQAPP-----LSQAQ 194
Cdd:pfam03154 359 PTTpiPQLPNPQSHKHPPHLSGPSPFQMNSNLPPPPAlkpLSSLSTHHPPSAhppplqLMPQSQQLPPPPaqppvLTQSQ 438
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 195 GHP--GIQTPQRSAPSQASSfTPPASGGPRLPSMTGPLLPGQsfgGPSVSQPNHVSS--PPQALPPGTQMTGPLG---PL 267
Cdd:pfam03154 439 SLPppAASHPPTSGLHQVPS-QSPFPQHPFVPGGPPPITPPS---GPPTSTSSAMPGiqPPSSASVSSSGPVPAAvscPL 514
|
....
gi 767964335 268 PPMH 271
Cdd:pfam03154 515 PPVQ 518
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
8-352 |
1.31e-10 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 65.94 E-value: 1.31e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 8 PPVPPFGQPQPIYPGYHQSSyggqsgstAPAIPYGAYNGPVPGYQQTPPQGMSRAPPSSGA--PPASTAQAPcgqaaygq 85
Cdd:pfam03154 255 PPPPSQVSPQPLPQPSLHGQ--------MPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSqvPPGPSPAAP-------- 318
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 86 fgqgdvqnGPSStvQMQRLPGSQPFGSPLAPVGNQP----PVLQPY-GPPPTS--AQVATQLSGMQISGAVAPAPPSSGL 158
Cdd:pfam03154 319 --------GQSQ--QRIHTPPSQSQLQSQQPPREQPlppaPLSMPHiKPPPTTpiPQLPNPQSHKHPPHLSGPSPFQMNS 388
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 159 GFGPPTSLAsasgsfPNSGLYGSYPQGQAPPLSQ--AQGHPgIQTPQRSAP--SQASSFTPPASGGPrlPSMTGPLLPGQ 234
Cdd:pfam03154 389 NLPPPPALK------PLSSLSTHHPPSAHPPPLQlmPQSQQ-LPPPPAQPPvlTQSQSLPPPAASHP--PTSGLHQVPSQ 459
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 235 SfggPSVSQPNHVSSPPQALPPGTqmtgplgplPPMHSPQQPGyqpqqngSFGPARGPQSNYGGPYPAAPTfgsqpgppQ 314
Cdd:pfam03154 460 S---PFPQHPFVPGGPPPITPPSG---------PPTSTSSAMP-------GIQPPSSASVSSSGPVPAAVS--------C 512
|
330 340 350
....*....|....*....|....*....|....*...
gi 767964335 315 PLPPKRLDPDAIPSPQLSELPPQQKTRHRIDPDAIPSP 352
Cdd:pfam03154 513 PLPPVQIKEEALDEAEEPESPPPPPRSPSPEPTVVNTP 550
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
6-254 |
5.86e-09 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 60.72 E-value: 5.86e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 6 SVPPVPPFGQPQPIYPGYHQSSYGGQSGS----TAPAIPYGAYNGPVPGYQQT--------PPQGMSRAPPSSGAPPAST 73
Cdd:PHA03247 2769 PAPPAAPAAGPPRRLTRPAVASLSESRESlpspWDPADPPAAVLAPAAALPPAaspagplpPPTSAQPTAPPPPPGPPPP 2848
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 74 AQAPCGQAAYGqfgqGDVQNGPSStvqmqRLPGSQPFGSPLAPVGN--------------QPPVLQPYGPPPTSAQVATQ 139
Cdd:PHA03247 2849 SLPLGGSVAPG----GDVRRRPPS-----RSPAAKPAAPARPPVRRlarpavsrstesfaLPPDQPERPPQPQAPPPPQP 2919
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 140 LSGMQISGAVAPAPPSSGLgfgPPTSLASASGSFPNSGlygsyPQGQAPPLSQAQGHPG-IQTPQRSAPSQASSFTPPAs 218
Cdd:PHA03247 2920 QPQPPPPPQPQPPPPPPPR---PQPPLAPTTDPAGAGE-----PSGAVPQPWLGALVPGrVAVPRFRVPQPAPSREAPA- 2990
|
250 260 270
....*....|....*....|....*....|....*.
gi 767964335 219 ggPRLPSMTGPLLPGQSFGGPSVSQPNHVSSPPQAL 254
Cdd:PHA03247 2991 --SSTPPLTGHSLSRVSSWASSLALHEETDPPPVSL 3024
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
29-304 |
4.33e-08 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 57.87 E-value: 4.33e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 29 GGQSGSTAPAIPYGAYNGPVPGYQQTPPQGMSRA--PPSSGAPPASTAQAPCGQAAYGQFGQ-GDVQNGPSSTVQmqrlP 105
Cdd:PHA03307 110 GPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSpgPPPAASPPAAGASPAAVASDAASSRQaALPLSSPEETAR----A 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 106 GSQPfgsPLAPVGNQPPVLQPYGPPPTSAQVATQLSGMQISGAVAPAPPSSGLGFGPPTSLASASGSFPNSGLYGSYPQG 185
Cdd:PHA03307 186 PSSP---PAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAP 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 186 QAPPLSQAQGHPGIQTPQRsAPSQASSFTPPASGGPRLPSM--TGPLLPGQSFGGPSVSQPNHVSSPPQALPPGTQMTGP 263
Cdd:PHA03307 263 ITLPTRIWEASGWNGPSSR-PGPASSSSSPRERSPSPSPSSpgSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAV 341
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 767964335 264 lGPLPPMHSPQQPGYQPQQNGSFGPARGPQSNYGGPYPAAP 304
Cdd:PHA03307 342 -SPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAAS 381
|
|
| SPT5 |
COG5164 |
Transcription elongation factor SPT5 [Transcription]; |
30-269 |
4.43e-08 |
|
Transcription elongation factor SPT5 [Transcription];
Pssm-ID: 444063 [Multi-domain] Cd Length: 495 Bit Score: 56.96 E-value: 4.43e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 30 GQSGSTAPAIPYGAyngpvpgyqQTPPQgmsraPPSSGAPPAST-AQAPCGQAAYGQFGQGDVQNGPSSTVQMQRLPGSQ 108
Cdd:COG5164 22 GSQGSTKPAQNQGS---------TRPAG-----NTGGTRPAQNQgSTTPAGNTGGTRPAGNQGATGPAQNQGGTTPAQNQ 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 109 pfGSPLAPvGNQPPVLQPYGPPPTSAQVATQLSGMQISGAvAPAPPSSGlgfgpPTSLASASGSFPNSGLYGSYPQGQAP 188
Cdd:COG5164 88 --GGTRPA-GNTGGTTPAGDGGATGPPDDGGATGPPDDGG-STTPPSGG-----STTPPGDGGSTPPGPGSTGPGGSTTP 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 189 PLSQAQGHPGIQTPQRSAPSQASSFTPPASGGPRLPSMTGPLLPGQSFGGPSVSQPNHVSSPPqalPPGTQMTGPLGPLP 268
Cdd:COG5164 159 PGDGGSTTPPGPGGSTTPPDDGGSTTPPNKGETGTDIPTGGTPRQGPDGPVKKDDKNGKGNPP---DDRGGKTGPKDQRP 235
|
.
gi 767964335 269 P 269
Cdd:COG5164 236 K 236
|
|
| Med15 |
pfam09606 |
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ... |
30-368 |
1.04e-07 |
|
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.
Pssm-ID: 312941 [Multi-domain] Cd Length: 732 Bit Score: 56.17 E-value: 1.04e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 30 GQSGSTAPAIPYGAYNGPVPGYQQTPPQGMSRAPPSSGAP--PASTAQAPCGQAAYGQFGQGDVQNGPsstvqMQRLPGS 107
Cdd:pfam09606 91 GQGTRPQMMGPMGPGPGGPMGQQMGGPGTASNLLASLGRPqmPMGGAGFPSQMSRVGRMQPGGQAGGM-----MQPSSGQ 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 108 QPFGSPLAPVGNQPPVlQPYGPPPTSAQVATQLSGM--QISGAVAPAPPSSGLGFGpptSLASASGSFPNSGLYGSYPQ- 184
Cdd:pfam09606 166 PGSGTPNQMGPNGGPG-QGQAGGMNGGQQGPMGGQMppQMGVPGMPGPADAGAQMG---QQAQANGGMNPQQMGGAPNQv 241
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 185 --GQAPP---LSQAQGHPGIQTPQRSAPS--QASSFTPPASGGPRLPSMTGPLLPGQSFGGPSVSQ-------------- 243
Cdd:pfam09606 242 amQQQQPqqqGQQSQLGMGINQMQQMPQGvgGGAGQGGPGQPMGPPGQQPGAMPNVMSIGDQNNYQqqqtrqqqqqqggn 321
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 244 --PNHVSSPPQALPPGTQMT---------------------GPLGPLPPMHSPQQPGYQPQQNGSFGPARGPQSN--YGG 298
Cdd:pfam09606 322 hpAAHQQQMNQSVGQGGQVValgglnhletwnpgnfgglgaNPMQRGQPGMMSSPSPVPGQQVRQVTPNQFMRQSpqPSV 401
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767964335 299 PYPAAPTFGSQPGPPqplppkrldPDAIPSPQLSELPPQQKTRHRIDPDAIP--SPIQVIEDDRNNRGTEPF 368
Cdd:pfam09606 402 PSPQGPGSQPPQSHP---------GGMIPSPALIPSPSPQMSQQPAQQRTIGqdSPGGSLNTPGQSAVNSPL 464
|
|
| Med15 |
pfam09606 |
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ... |
71-299 |
1.72e-07 |
|
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.
Pssm-ID: 312941 [Multi-domain] Cd Length: 732 Bit Score: 55.40 E-value: 1.72e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 71 ASTAQAPCGQAAYGQFGQGdvQNG---PSSTVQMQRLPGSQPFGSPLAPVGNQPPVLQPYGPPPTSAQVATQLS--GMQI 145
Cdd:pfam09606 57 AAQQQQPQGGQGNGGMGGG--QQGmpdPINALQNLAGQGTRPQMMGPMGPGPGGPMGQQMGGPGTASNLLASLGrpQMPM 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 146 SGAVAPAPPSSGLGFGPPtslASASGSFPNSGLYGSYPQGQAPPLSQAQGHPGIQTPQRSAPSQASSFTPPASGGPRLPS 225
Cdd:pfam09606 135 GGAGFPSQMSRVGRMQPG---GQAGGMMQPSSGQPGSGTPNQMGPNGGPGQGQAGGMNGGQQGPMGGQMPPQMGVPGMPG 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 226 MT-------------GPLLPGQSFGGPsvsqPNHVSSPPQALPPGTQMTGPLGPLPPMHspqqpgyQPQQNGSFGPARGP 292
Cdd:pfam09606 212 PAdagaqmgqqaqanGGMNPQQMGGAP----NQVAMQQQQPQQQGQQSQLGMGINQMQQ-------MPQGVGGGAGQGGP 280
|
....*..
gi 767964335 293 QSNYGGP 299
Cdd:pfam09606 281 GQPMGPP 287
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
120-355 |
2.32e-07 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 55.16 E-value: 2.32e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 120 QPPVLQPYGPPPTSAQVATQLSGMQISGAVAPAPPSSGLGFGPPTSLAsasgsfPNSglygsyPQGQAPPLSQAQGHPGI 199
Cdd:pfam03154 170 QPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQP------PNQ------TQSTAAPHTLIQQTPTL 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 200 QTPQRSAP----SQASSFTPPASGGPR---LPSMTGPLLPGqsfGGPSVSQPNHVSSP--PQALPPGTQMTGPLGPLPPM 270
Cdd:pfam03154 238 HPQRLPSPhpplQPMTQPPPPSQVSPQplpQPSLHGQMPPM---PHSLQTGPSHMQHPvpPQPFPLTPQSSQSQVPPGPS 314
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 271 HSPQQPGYQPQQN-GSFGPARGPQSNYGGPYPAAPtfgsqpgppqpLPPKRLDPDaiPSPQLSELPPQQKTRHRIDPDAi 349
Cdd:pfam03154 315 PAAPGQSQQRIHTpPSQSQLQSQQPPREQPLPPAP-----------LSMPHIKPP--PTTPIPQLPNPQSHKHPPHLSG- 380
|
....*.
gi 767964335 350 PSPIQV 355
Cdd:pfam03154 381 PSPFQM 386
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
5-269 |
3.02e-07 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 54.77 E-value: 3.02e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 5 QSVPPVPPFGQPQPIYPGYHQSSYGGQSGSTAPAIPYGAYNGPVPGYQQTPPQGMS----RAPPSSGAPPASTAQA---P 77
Cdd:pfam03154 296 QPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSmphiKPPPTTPIPQLPNPQShkhP 375
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 78 CGQAAYGQFGQGDVQNGPSSTVQMQRLPGSQP------------FGSPLAPVGNQPPVL-QPYGPPPTSAQVATQlSGMQ 144
Cdd:pfam03154 376 PHLSGPSPFQMNSNLPPPPALKPLSSLSTHHPpsahppplqlmpQSQQLPPPPAQPPVLtQSQSLPPPAASHPPT-SGLH 454
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 145 ISGAVAPAPPSSGLGFGPPTSLasasgsfPNSGlygsypqgqaPPLSQAQGHPGIQTPqrsapsqasSFTPPASGGPrLP 224
Cdd:pfam03154 455 QVPSQSPFPQHPFVPGGPPPIT-------PPSG----------PPTSTSSAMPGIQPP---------SSASVSSSGP-VP 507
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 767964335 225 SMTGPLLPGQSFGGPSVSQPNHVSSPPqalPPgtqmtgPLGPLPP 269
Cdd:pfam03154 508 AAVSCPLPPVQIKEEALDEAEEPESPP---PP------PRSPSPE 543
|
|
| PPE |
COG5651 |
PPE-repeat protein [Function unknown]; |
5-241 |
3.18e-07 |
|
PPE-repeat protein [Function unknown];
Pssm-ID: 444372 [Multi-domain] Cd Length: 385 Bit Score: 54.13 E-value: 3.18e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 5 QSVPPVPPfgqPQPIYpgyhqsSYGGQSGSTAPAIPYGAYNGPVPGYQQTPPQGMSRAPPSSGAPPAStaqAPCGQAAYG 84
Cdd:COG5651 163 ALTPFTQP---PPTIT------NPGGLLGAQNAGSGNTSSNPGFANLGLTGLNQVGIGGLNSGSGPIG---LNSGPGNTG 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 85 QFGQGDVQNGPSSTVQMQRLPGSQPFGSPLAPVGNQPPVLQPYGPPPTSAQVATQLSGMQISGAVAPAPPSSGLGFGPPT 164
Cdd:COG5651 231 FAGTGAAAGAAAAAAAAAAAAGAGASAALASLAATLLNASSLGLAATAASSAATNLGLAGSPLGLAGGGAGAAAATGLGL 310
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767964335 165 SLASASGSFPNSGLYGSYPQGQAPPLSQAQGHPGIQTPqrSAPSQASSFTPPASGGPRLPSMTGPLLPGQSFGGPSV 241
Cdd:COG5651 311 GAGGAAGAAGATGAGAALGAGAAAAAAGAAAGAGAAAA--AAAGGAGGGGGGALGAGGGGGSAGAAAGAASGGGAAA 385
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
29-233 |
6.07e-07 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 53.73 E-value: 6.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 29 GGQSGSTAPAIPYGAyngpvPGYQQTPPQGMSR-APPSSGAPPASTAQAPCGQAAYGQFGQGDVQNGPS-STVQMQRLPG 106
Cdd:PRK12323 366 GQSGGGAGPATAAAA-----PVAQPAPAAAAPAaAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPApEALAAARQAS 440
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 107 SQPFGSPLAPVGNQPPVLQPYGPPPTSAQVATQLSGMQISGAVAPAPPSSGLGFGPPtSLASASGSFPNSGLYGSYPqgq 186
Cdd:PRK12323 441 ARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPP-PWEELPPEFASPAPAQPDA--- 516
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 767964335 187 APPLSQAQGHPGIQTPQRSAPSQASSFTPPASGGPRLPSMTGPLLPG 233
Cdd:PRK12323 517 APAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAP 563
|
|
| PHA03377 |
PHA03377 |
EBNA-3C; Provisional |
8-197 |
3.48e-06 |
|
EBNA-3C; Provisional
Pssm-ID: 177614 [Multi-domain] Cd Length: 1000 Bit Score: 51.21 E-value: 3.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 8 PPVPPFGQPQPIYPGYHQSSYGGQSGSTAPAIPYGAYNGPVPGYQQTPPQGMSRAP--PSSGAPPASTAQAPC-GQAAYG 84
Cdd:PHA03377 770 PQAPYLGYQEPQAQGVQVSSYPGYAGPWGLRAQHPRYRHSWAYWSQYPGHGHPQGPwaPRPPHLPPQWDGSAGhGQDQVS 849
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 85 QFGQGDVQNGPSS--TVQMQRLPGSQPFGSPLAPVGNQPPVLQPYGPPPTSAqvatqlsgmqisgavapAPPSSGLGFGP 162
Cdd:PHA03377 850 QFPHLQSETGPPRlqLSQVPQLPYSQTLVSSSAPSWSSPQPRAPIRPIPTRF-----------------PPPPMPLQDSM 912
|
170 180 190
....*....|....*....|....*....|....*
gi 767964335 163 PTSLASASGSFPNSGLYGSYPQGQAPPLSQAQGHP 197
Cdd:PHA03377 913 AVGCDSSGTACPSMPFASDYSQGAFTPLDINAQTP 947
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
40-256 |
4.28e-06 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 51.14 E-value: 4.28e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 40 PYGAYNGPVPGYQQTPPQGMSRAPPSSGAPPASTAQAPCGQAAygqfgqgdvqngPSSTVQMQRLPGSQPFGSPLAPVGN 119
Cdd:PRK07764 592 PGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAA------------APAEASAAPAPGVAAPEHHPKHVAV 659
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 120 QPPVLQPYGPPPTSAQVAtqlsgmQISGAVAPAPPSSGLGFGPPTSLASASGSfpnsglygsyPQGQAPPLSQAQGHPGI 199
Cdd:PRK07764 660 PDASDGGDGWPAKAGGAA------PAAPPPAPAPAAPAAPAGAAPAQPAPAPA----------ATPPAGQADDPAAQPPQ 723
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 767964335 200 QTPQRSAPSQASSFTPPASGGPRLPSMTGPlLPGQSFGGPSVSQPNHVSSPPQALPP 256
Cdd:PRK07764 724 AAQGASAPSPAADDPVPLPPEPDDPPDPAG-APAQPPPPPAPAPAAAPAAAPPPSPP 779
|
|
| MISS |
pfam15822 |
MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic ... |
102-304 |
5.17e-06 |
|
MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic MAPK-interacting and spindle-stabilising protein-like proteins. MISS is rich in prolines and has four potential MAPK-phosphorylation sites, a MAPK-docking site, a PEST sequence (PEST motif) and a bipartite nuclear localization signal. The endogenous protein accumulates during mouse meiotic maturation and is found as discrete dots on the MII spindle. MISS is the first example of a physiological MAPK-substrate that is stabilized in MII that specifically regulates MII spindle integrity during the CSF arrest.
Pssm-ID: 318115 [Multi-domain] Cd Length: 238 Bit Score: 49.21 E-value: 5.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 102 QRLPGSQPFGSPLAPVG-------NQPPVLQPYGPPPTSAQVATQLSGMQiSGAVAPAPPsSGLGFGPPtslasaSGSFP 174
Cdd:pfam15822 28 QGWPGSNPWNNPSAPPAvpsglppSTAPSTVPFGPAPTGMYPSIPLTGPS-PGPPAPFPP-SGPSCPPP------GGPYP 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 175 NSGLYGSYPQGQAPPlsqaqghPGIQTPQrsAPSQASSFTPPASGGPRLP--SM-TGPLLPGQSFGGPSVSQPNHVSSPP 251
Cdd:pfam15822 100 APTVPGPGPIGPYPT-------PNMPFPE--LPRPYGAPTDPAAAAPSGPwgSMsSGPWAPGMGGQYPAPNMPYPSPGPY 170
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 767964335 252 QALPP----GTQMTGPLGPLPPmhspqqpgyqpQQNGSFGPARGPQSNYG--GPYPAAP 304
Cdd:pfam15822 171 PAVPPpqspGAAPPVPWGTVPP-----------GPWGPPAPYPDPTGSYPmpGLYPTPN 218
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
8-139 |
5.58e-06 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 50.75 E-value: 5.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 8 PPVPPFGQPQPIYPGYHQSSYGGQSGSTAPAiPYGAYNGPVPGYQQTPPQGmsrAPPSSGAPPASTAQAPCGQAAYGQFG 87
Cdd:PRK07764 652 HHPKHVAVPDASDGGDGWPAKAGGAAPAAPP-PAPAPAAPAAPAGAAPAQP---APAPAATPPAGQADDPAAQPPQAAQG 727
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 767964335 88 QGDVQNGPSSTVQMQRLPGSQPFGSPLAPVGNQPPVLQPYGPPPTSAQVATQ 139
Cdd:PRK07764 728 ASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPP 779
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
5-304 |
1.70e-05 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 49.40 E-value: 1.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 5 QSVPPVPPFGQPQPIYPGYHQSSYGGQSGSTAPAIPYGAYNGPVPGYQQTPPQGM---------SRAPPSSGAPPASTAQ 75
Cdd:PHA03307 119 PTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAAlplsspeetARAPSSPPAEPPPSTP 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 76 ------------------APCGQAAYGQFGQGDVQNGPSSTVQMQR------------LPGSQPFGSPLAPVGNQPPVLQ 125
Cdd:PHA03307 199 paaasprpprrsspisasASSPAPAPGRSAADDAGASSSDSSSSESsgcgwgpenecpLPRPAPITLPTRIWEASGWNGP 278
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 126 PYGPPPTSAQVATQLSgmqiSGAVAPAPPSSGLGFGPPTSLASASGSfPNSGLYGSYPQGQAPplSQAQGHPGiQTPQRS 205
Cdd:PHA03307 279 SSRPGPASSSSSPRER----SPSPSPSSPGSGPAPSSPRASSSSSSS-RESSSSSTSSSSESS--RGAAVSPG-PSPSRS 350
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 206 APSQASSftPPASGGPrlPSMTGPLLPGQSFGGPSVSQPNHVSSPPQALPPGTQMTGPlGPLPPMHSPQQPGYQPQQNGS 285
Cdd:PHA03307 351 PSPSRPP--PPADPSS--PRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDAT-GRFPAGRPRPSPLDAGAASGA 425
|
330 340
....*....|....*....|
gi 767964335 286 FgPARGPQ-SNYGGPYPAAP 304
Cdd:PHA03307 426 F-YARYPLlTPSGEPWPGSP 444
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
40-304 |
1.92e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 49.17 E-value: 1.92e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 40 PYGAYNGPVPGYQQTPPqgmSRAPPSSGAP-PASTAQAPCGQAAYGQFGQ---------GDVQNGPSSTvqmqrLPGSQP 109
Cdd:PHA03247 2489 PFAAGAAPDPGGGGPPD---PDAPPAPSRLaPAILPDEPVGEPVHPRMLTwirgleelaSDDAGDPPPP-----LPPAAP 2560
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 110 FGSPLAPVGNQPPVLQPYGPPPTSAQVATQLSGMQISGAVAPAPPSSGLGFGPPTSL----------ASASGSFPNSGLY 179
Cdd:PHA03247 2561 PAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLppdthapdppPPSPSPAANEPDP 2640
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 180 GSYPQGQAPPLSQAQGHPGIQTPQRSAPSQASSFTPPAS-GGPRLPSMTGPLLPGQSFGGPSVSQPNHVSSPPQA----- 253
Cdd:PHA03247 2641 HPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPpQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALvsatp 2720
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 767964335 254 LPPGTQMTGPLGPLPPMH-SPQQPGYQPQQNGSFGPARGPQSNYGGPYPAAP 304
Cdd:PHA03247 2721 LPPGPAAARQASPALPAApAPPAVPAGPATPGGPARPARPPTTAGPPAPAPP 2772
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
29-266 |
2.43e-05 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 48.69 E-value: 2.43e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 29 GGQSGSTAPAIPY-GAYNGPVPGYQQTPPQGMSRAPPSSGAPPASTAQAPCGQAAYGQFGQGDVQNGPSSTVQMQRLPGS 107
Cdd:PRK07003 370 GGVPARVAGAVPApGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADGDAPV 449
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 108 QPFGSPLAPVGNQPPVLQPyGPPPTSAQVATQLSGMQISGAVAPAPPSSGLgfGPPTSLASASGSFPNSGLYGSYPQGQA 187
Cdd:PRK07003 450 PAKANARASADSRCDERDA-QPPADSGSASAPASDAPPDAAFEPAPRAAAP--SAATPAAVPDARAPAAASREDAPAAAA 526
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 188 PPLSQA-QGHPGIQTPQRSAPSQASSFTPPASGGPRLPSMTGPLLPGQSfgGPSVSQPnhVSSPPQALPPGTQMTGPLGP 266
Cdd:PRK07003 527 PPAPEArPPTPAAAAPAARAGGAAAALDVLRNAGMRVSSDRGARAAAAA--KPAAAPA--AAPKPAAPRVAVQVPTPRAR 602
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
107-330 |
2.71e-05 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 48.44 E-value: 2.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 107 SQPFGSPLAPVGNQPPVLQPYGPPPTSAQVATQLSGMQISGAVAPAPPSSGLGFGPPTSLASASGSFPNSGLYGSYPQGQ 186
Cdd:PRK07764 601 PAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAA 680
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 187 APPLSQAQGHPGIQTPQRSAPSQASSFTPPASGGPRlpSMTGPLLPGQSFGGPSVSQPNHVSSPPQALPPGTQMTGPLGP 266
Cdd:PRK07764 681 PPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADD--PAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQP 758
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767964335 267 LPPMHSPQqpgyqpqqngsfGPARGPQSNYGGPYPAAPTFgsqpgppqplppkrldPDAIPSPQ 330
Cdd:PRK07764 759 PPPPAPAP------------AAAPAAAPPPSPPSEEEEMA----------------EDDAPSMD 794
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
7-352 |
3.09e-05 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 48.14 E-value: 3.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 7 VPPVPPFGQPQPIYPGYHQSSYGGQSGSTAPAIPYGAYNGPVPGYQQ---------TPPQGMSRAPPSSGAP-----PAS 72
Cdd:PHA03378 525 LPPSPPQPRAGRRAPCVYTEDLDIESDEPASTEPVHDQLLPAPGLGPlqiqpltspTTSQLASSAPSYAQTPwpvphPSQ 604
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 73 TAQAPCGQAAYGQFGQGDVQNGPSSTVQMQRLPGSQ-PFGSPLAPVGNQPPVLQ--------------PYGPPPTSAQVA 137
Cdd:PHA03378 605 TPEPPTTQSHIPETSAPRQWPMPLRPIPMRPLRMQPiTFNVLVFPTPHQPPQVEitpykptwtqighiPYQPSPTGANTM 684
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 138 TQLSG----MQI-SGAVAPAPPSSGlgfgPPTSL----ASASGSFPNSGLYGSY--PQGQAPPLSQAQGHPGIQTPQRSA 206
Cdd:PHA03378 685 LPIQWapgtMQPpPRAPTPMRPPAA----PPGRAqrpaAATGRARPPAAAPGRArpPAAAPGRARPPAAAPGRARPPAAA 760
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 207 PSQASS-FTPPASGGPRLPSMTGPLLPGQSFGGPSVSQPnhvsspPQALPPGTQMTGPLGPL---PPMHSPQQPGYQPQQ 282
Cdd:PHA03378 761 PGRARPpAAAPGAPTPQPPPQAPPAPQQRPRGAPTPQPP------PQAGPTSMQLMPRAAPGqqgPTKQILRQLLTGGVK 834
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 283 NG--------------SFGPARGPQSNYGGPYPAAPTFGSQPGPPQPLPPKRLDPDAIPSPQLSELPPQQKTRHR----I 344
Cdd:PHA03378 835 RGrpslkkpaalerqaAAGPTPSPGSGTSDKIVQAPVFYPPVLQPIQVMRQLGSVRAAAASTVTQAPTEYTGERRgvgpM 914
|
....*...
gi 767964335 345 DPDAIPSP 352
Cdd:PHA03378 915 HPTDIPPS 922
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
29-224 |
3.81e-05 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 48.06 E-value: 3.81e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 29 GGQSGSTAPAIPYGAYNGPVPGYQQTPPQGMSRAPPSSGAPPA--STAQAPCGQAAYGQFGQGDVQNGPSSTVQMQRLPG 106
Cdd:PRK07764 595 AGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAeaSAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAG 674
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 107 S-QPFGSPLAPVGNQPPVLQPYGPPPTSAQVATQLSGMQISGAvAPAPPSSGLGFGPPTSLASASGSFPNsglYGSYPQG 185
Cdd:PRK07764 675 GaAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDP-AAQPPQAAQGASAPSPAADDPVPLPP---EPDDPPD 750
|
170 180 190
....*....|....*....|....*....|....*....
gi 767964335 186 QAPPLSQAQGHPGiqTPQRSAPSQASSFTPPASGGPRLP 224
Cdd:PRK07764 751 PAGAPAQPPPPPA--PAPAAAPAAAPPPSPPSEEEEMAE 787
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
5-222 |
6.23e-05 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 47.29 E-value: 6.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 5 QSVPPVPPFGQPQPiypgyhqssyggqSGSTAPAIPygayNGPVPGYQQTPPQGMSRAPPSSGAPPASTAQAPCGQAAYG 84
Cdd:PRK07764 602 APASSGPPEEAARP-------------AAPAAPAAP----AAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASD 664
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 85 QFGQGDVQNGPSSTVQMqrlPGSQPFGSPLAPVGNQPPVLQPYGPPPTSAQVATQLSGMQISGAVAPAPPSSGLGFGPPT 164
Cdd:PRK07764 665 GGDGWPAKAGGAAPAAP---PPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPL 741
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 767964335 165 SLASASGSFPNSGLYGSYPQGQAPPLSQAQGHPGIQTPQRSAPSQASSFTPPASGGPR 222
Cdd:PRK07764 742 PPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAEDDAPSMDDEDRR 799
|
|
| DUF5585 |
pfam17823 |
Family of unknown function (DUF5585); This is a family of unknown function found in chordata. |
32-263 |
1.76e-04 |
|
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
Pssm-ID: 465521 [Multi-domain] Cd Length: 506 Bit Score: 45.34 E-value: 1.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 32 SGSTAPAIPYGAYNGPVPGYQQT-----PPQGMSRAPPSSGAPPASTAQAPCG---------QAAYGQFGQGDVQNGPSS 97
Cdd:pfam17823 180 SSTTAASSTTAASSAPTTAASSApatltPARGISTAATATGHPAAGTALAAVGnsspaagtvTAAVGTVTPAALATLAAA 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 98 TVQMQRLPGSQPFGSP----LAPVGNQPPVLQPYGPPPTS--------AQVATQLSGMQISGAVAPAPPSSGLGFGPPTS 165
Cdd:pfam17823 260 AGTVASAAGTINMGDPharrLSPAKHMPSDTMARNPAAPMgaqaqgpiIQVSTDQPVHNTAGEPTPSPSNTTLEPNTPKS 339
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 166 LASASGSFPNSglygSYPQGQAPPLSQAQGHPGIQTPQRSAPSQASSftppasggprlPSmtgPLLPGQSFGGPSVSQ-P 244
Cdd:pfam17823 340 VASTNLAVVTT----TKAQAKEPSASPVPVLHTSMIPEVEATSPTTQ-----------PS---PLLPTQGAAGPGILLaP 401
|
250
....*....|....*....
gi 767964335 245 NHVSSPPQalpPGTQMTGP 263
Cdd:pfam17823 402 EQVATEAT---AGTASAGP 417
|
|
| PLN03209 |
PLN03209 |
translocon at the inner envelope of chloroplast subunit 62; Provisional |
7-268 |
2.79e-04 |
|
translocon at the inner envelope of chloroplast subunit 62; Provisional
Pssm-ID: 178748 [Multi-domain] Cd Length: 576 Bit Score: 44.92 E-value: 2.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 7 VPPVPP-FGQPQPIYPGYHQSSYGGQSGSTAPAIPYGAYNgpvpgyQQTPPQGMSRAPPSSGAPPASTAQApcgqaaygq 85
Cdd:PLN03209 339 PKPVPTkPVTPEAPSPPIEEEPPQPKAVVPRPLSPYTAYE------DLKPPTSPIPTPPSSSPASSKSVDA--------- 403
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 86 FGQGDVQNGPSSTVQMQRLPGSQPFGsplAPVGNQPPvLQPYG-----PPPTSAqvatqlsgmqisgavAPAPPSsglGF 160
Cdd:PLN03209 404 VAKPAEPDVVPSPGSASNVPEVEPAQ---VEAKKTRP-LSPYAryedlKPPTSP---------------SPTAPT---GV 461
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 161 GPPTSLASASGSFPNSGLYGSYPQGQAPPlsQAQGHPGIQTPQRSAPSQASSFTPPASGGPRLPSMTGPLLPGQSFGGPS 240
Cdd:PLN03209 462 SPSVSSTSSVPAVPDTAPATAATDAAAPP--PANMRPLSPYAVYDDLKPPTSPSPAAPVGKVAPSSTNEVVKVGNSAPPT 539
|
250 260 270
....*....|....*....|....*....|...
gi 767964335 241 --VSQPNHVSSPPQALPPGT---QMTGPLGPLP 268
Cdd:PLN03209 540 alADEQHHAQPKPRPLSPYTmyeDLKPPTSPTP 572
|
|
| PHA03379 |
PHA03379 |
EBNA-3A; Provisional |
9-350 |
4.12e-04 |
|
EBNA-3A; Provisional
Pssm-ID: 223066 [Multi-domain] Cd Length: 935 Bit Score: 44.66 E-value: 4.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 9 PVPPFGQPQPIYP-GYHQSSYGGQSGSTAPAIPYGAYNGPV-------PG-YQQTPPQGMSR--------APPSSGAPPA 71
Cdd:PHA03379 416 PRPPVEKPRPEVPqSLETATSHGSAQVPEPPPVHDLEPGPLhdqhsmaPCpVAQLPPGPLQDlepgdqlpGVVQDGRPAC 495
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 72 STAQAPCG------QAAYGQFGQgdVQNGPSSTVQMQRLPGSQPFGSPLAPVGNQPPVLQPYGPPPTSAQVATQLSGMQI 145
Cdd:PHA03379 496 APVPAPAGpivrpwEASLSQVPG--VAFAPVMPQPMPVEPVPVPTVALERPVCPAPPLIAMQGPGETSGIVRVRERWRPA 573
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 146 SGAVAPAPPSSGLGF--GP-----------------PTSLASASGSFPNSG-------LYGSYPQGQAPPLSQAQGHPGI 199
Cdd:PHA03379 574 PWTPNPPRSPSQMSVrdRLarlraeaqpyqasvevqPPQLTQVSPQQPMEYplepeqqMFPGSPFSQVADVMRAGGVPAM 653
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 200 QTPQRSAPSQassfTPPASGGPRLP--SMTGPLLP-----GQSFGGPSVSQPNHVSSPPQALPPgTQMTGPLGPLPPMHS 272
Cdd:PHA03379 654 QPQYFDLPLQ----QPISQGAPLAPlrASMGPVPPvpatqPQYFDIPLTEPINQGASAAHFLPQ-QPMEGPLVPERWMFQ 728
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 273 PQQPGYqpqqngSFGPARGPQSNYGGPY--------PAAPTFGSQPGPPQPLPPKRLDPDAIPSPQLSELPPQ----QKT 340
Cdd:PHA03379 729 GATLSQ------SVRPGVAQSQYFDLPLtqpinhgaPAAHFLHQPPMEGPWVPEQWMFQGAPPSQGTDVVQHQldalGYV 802
|
410
....*....|
gi 767964335 341 RHRIDPDAIP 350
Cdd:PHA03379 803 LHVLNHPGVP 812
|
|
| SP2_N |
cd22540 |
N-terminal domain of transcription factor Specificity Protein (SP) 2; Specificity Proteins ... |
5-242 |
4.81e-04 |
|
N-terminal domain of transcription factor Specificity Protein (SP) 2; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. SP2 contains the least conserved DNA-binding domain within the SP subfamily of proteins, and its DNA sequence specificity differs from the other SP proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate, or in some cases, repress expression from different promoters. The transcription factor SP2 serves as a paradigm for indirect genomic binding. It does not require its DNA-binding domain for genomic DNA binding and occupies target promoters independently of whether they contain a cognate DNA-binding motif. SP2 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. SP1-4 have similar N-terminal transactivation domains characterized by glutamine-rich regions, which, in most cases, have adjacent serine/threonine-rich regions. This model represents the N-terminal domain of SP2.
Pssm-ID: 411776 [Multi-domain] Cd Length: 511 Bit Score: 44.15 E-value: 4.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 5 QSVPPVPPFGQPQPIYPGYHQSSYGG-------------QSGST-APAIPY--------GAYNGPVPGYQQTPPQGMSRA 62
Cdd:cd22540 159 QVLQQPQQAHKPVPIKPAPLQTSNTNsaslqvpgnviklQSGGNvALTLPVnnlvgtqdGATQLQLAAAPSKPSKKIRKK 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 63 PPSSGAPPASTAQAPcgQAAYGQFGQGD-VQNGPSSTVQMQrlpgsqpfgsplaPVGNQPPVLQPYG--PPPTSAQVAT- 138
Cdd:cd22540 239 SAQAAQPAVTVAEQV--ETVLIETTADNiIQAGNNLLIVQS-------------PGTGQPAVLQQVQvlQPKQEQQVVQi 303
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 139 ---QLSGMQISGAVAPAPPSSglgfgPPTSLASASGSFPNSGLYGSYPQGQAPPLSQAQGHPGIQTPQRSAPSQASSFTP 215
Cdd:cd22540 304 pqqALRVVQAASATLPTVPQK-----PLQNIQIQNSEPTPTQVYIKTPSGEVQTVLLQEAPAATATPSSSTSTVQQQVTA 378
|
250 260 270
....*....|....*....|....*....|
gi 767964335 216 P-ASGGPRLPSMT--GPLLPGQSFGGPSVS 242
Cdd:cd22540 379 NnGTGTSKPNYNVrkERTLPKIAPAGGIIS 408
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
47-218 |
5.12e-04 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 44.07 E-value: 5.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 47 PVPGYQQTPPQGMSRAPPssGAPPASTAQAPCGQAAYGQFGQGDVQNGPSSTVqmqrlpgSQPFGSPLAPVGNQPPVLQP 126
Cdd:PRK07003 360 PAVTGGGAPGGGVPARVA--GAVPAPGARAAAAVGASAVPAVTAVTGAAGAAL-------APKAAAAAAATRAEAPPAAP 430
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 127 ygPPPTSAQVATQLSGMQISGAVAPAPPSSglgfgPPTSLASASGSFPNSGLYGSYPQGQAPPLSQAQGHPGIQTPQRSA 206
Cdd:PRK07003 431 --APPATADRGDDAADGDAPVPAKANARAS-----ADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAAT 503
|
170
....*....|..
gi 767964335 207 PSQASSFTPPAS 218
Cdd:PRK07003 504 PAAVPDARAPAA 515
|
|
| dermokine |
cd21118 |
dermokine; Dermokine, also known as epidermis-specific secreted protein SK30/SK89, is a ... |
27-262 |
5.67e-04 |
|
dermokine; Dermokine, also known as epidermis-specific secreted protein SK30/SK89, is a skin-specific glycoprotein that may play a regulatory role in the crosstalk between barrier dysfunction and inflammation, and therefore play a role in inflammatory diseases such as psoriasis. Dermokine is one of the most highly expressed proteins in differentiating keratinocytes, found mainly in the spinous and granular layers of the epidermis, but also in the epithelia of the small intestine, macrophages of the lung, and endothelial cells of the lung. Mouse dermokine has been reported to be encoded by 22 exons, and its expression leads to alpha, beta, and gamma transcripts.
Pssm-ID: 411053 [Multi-domain] Cd Length: 495 Bit Score: 43.83 E-value: 5.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 27 SYGGQSGSTApaipYGAYNGPvpGYQQTPPQGMSRAPPSSGAPPASTAQApcgqAAYGQFGQGDVQNGPSSTvqmqrlPG 106
Cdd:cd21118 120 SWQGSGGHGA----YGSQGGP--GVQGHGIPGGTGGPWASGGNYGTNSLG----GSVGQGGNGGPLNYGTNS------QG 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 107 SQPFGSPLAPVGNQppvlQPYG---PPPTSAQVATQLSGMQISGAVAPAPPSSGLGFGPPTSLASASGS-------FPNS 176
Cdd:cd21118 184 AVAQPGYGTVRGNN----QNSGctnPPPSGSHESFSNSGGSSSSGSSGSQGSHGSNGQGSSGSSGGQGNggnngssSSNS 259
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 177 GLYGSYPQGQAPPLSQAQGHPGIQTPQRSAPSqASSFTPPASGGPRLPSMTGPllpgqsfgGPSVSQPNHVSSPPQALPP 256
Cdd:cd21118 260 GNSGGSNGGSSGNSGSGSGGSSSGGSNGWGGS-SSSGGSGGSGGGNKPECNNP--------GNDVRMAGGGGSQGSKESS 330
|
....*.
gi 767964335 257 GTQMTG 262
Cdd:cd21118 331 GSHGSN 336
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
5-250 |
5.90e-04 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 44.31 E-value: 5.90e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 5 QSVPPVPPFGQPQPIY------PGYHQSSYGGQSGSTAPAIPYGAYNGPVPGyQQTPPQGMSRAPPSSGAPPASTAQAPC 78
Cdd:PRK10263 378 EGYPQQSQYAQPAVQYneplqqPVQPQQPYYAPAAEQPAQQPYYAPAPEQPA-QQPYYAPAPEQPVAGNAWQAEEQQSTF 456
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 79 GQAAYGQFGQGDVQNGPSSTVQMQRLPGSQPFGSPLAPVGNQppvLQPYGPP--------PTSAQVATQLSGMQisgAVA 150
Cdd:PRK10263 457 APQSTYQTEQTYQQPAAQEPLYQQPQPVEQQPVVEPEPVVEE---TKPARPPlyyfeeveEKRAREREQLAAWY---QPI 530
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 151 PAPPSSGLGFGPPTSLASASGSFPNSGLYGSYPqgQAPPLSQAQGHPGIqtpqrSAPSQASSFTPPASGGPRLPSMTGPl 230
Cdd:PRK10263 531 PEPVKEPEPIKSSLKAPSVAAVPPVEAAAAVSP--LASGVKKATLATGA-----AATVAAPVFSLANSGGPRPQVKEGI- 602
|
250 260
....*....|....*....|
gi 767964335 231 lpgqsfgGPSVSQPNHVSSP 250
Cdd:PRK10263 603 -------GPQLPRPKRIRVP 615
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
59-355 |
6.77e-04 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 43.90 E-value: 6.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 59 MSRAPPSSGAPPASTAQAPCgqAAYGQFGQGDVQNGPSSTVQMQRLPGSQPfgsplAPVGNQPPVLQPYGPPPTSAQVAT 138
Cdd:PHA03378 521 MATLLPPSPPQPRAGRRAPC--VYTEDLDIESDEPASTEPVHDQLLPAPGL-----GPLQIQPLTSPTTSQLASSAPSYA 593
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 139 QLSGMQISGAVAPAPPSSGLGfgPPTSLASASGSFPNSGLYGSYPQGQAPPLSQAQGHPGIQTPQRSAPSQASSFTPPAS 218
Cdd:PHA03378 594 QTPWPVPHPSQTPEPPTTQSH--IPETSAPRQWPMPLRPIPMRPLRMQPITFNVLVFPTPHQPPQVEITPYKPTWTQIGH 671
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 219 GgPRLPSMTGP--LLPGQSfgGPSVSQPNHVS---SPPQALPPGTQMTGPLGPLPPMHSPQQPGYQPQQNGSFGPARGPQ 293
Cdd:PHA03378 672 I-PYQPSPTGAntMLPIQW--APGTMQPPPRAptpMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPA 748
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767964335 294 SN-------YGGPYPAAPTFGSQPGPpQPLPPKRLDPDAIPSPQLSELPPQQktrhridPDAIPSPIQV 355
Cdd:PHA03378 749 AApgrarppAAAPGRARPPAAAPGAP-TPQPPPQAPPAPQQRPRGAPTPQPP-------PQAGPTSMQL 809
|
|
| hnRNP-R-Q |
TIGR01648 |
heterogeneous nuclear ribonucleoprotein R, Q family; Sequences in this subfamily include the ... |
12-193 |
7.34e-04 |
|
heterogeneous nuclear ribonucleoprotein R, Q family; Sequences in this subfamily include the human heterogeneous nuclear ribonucleoproteins (hnRNP) R, Q, and APOBEC-1 complementation factor (aka APOBEC-1 stimulating protein). These proteins contain three RNA recognition domains (rrm: pfam00076) and a somewhat variable C-terminal domain.
Pssm-ID: 273732 [Multi-domain] Cd Length: 578 Bit Score: 43.45 E-value: 7.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 12 PFGQPQPIYPGYHQSSYGGQSGSTAPAIPYGAYngpVPGYQQTPPQGMSRAPPSSGAPPASTAQapcgqaaYGQFGQGdv 91
Cdd:TIGR01648 383 GRGYPPYGYEAYYGDYYGYHDYRGKYEDKYYGY---DPGMELTPMNPVRGKPGGRGGRPAIPPP-------RGRKNGA-- 450
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 92 qnGPSSTVQMQRLPGSQPFGSPLApvGNQPPVLQPYGPPPTSAQVatqlsgmqiSGAVAPAPPSSGLGFGPPTSlaSASG 171
Cdd:TIGR01648 451 --PPPAIGQDGRQLFLYKITIPAG--YSQRPAPHPLGPPRGSAFV---------RGARGGPAQYQQRGRGSRTS--RGNG 515
|
170 180
....*....|....*....|..
gi 767964335 172 SFPNSGLYGSYPQGQAPPLSQA 193
Cdd:TIGR01648 516 RGGTAGGKRKAFDGYAQPDATA 537
|
|
| Glutenin_hmw |
pfam03157 |
High molecular weight glutenin subunit; Members of this family include high molecular weight ... |
14-298 |
9.20e-04 |
|
High molecular weight glutenin subunit; Members of this family include high molecular weight subunits of glutenin. This group of gluten proteins is thought to be largely responsible for the elastic properties of gluten, and hence, doughs. Indeed, glutenin high molecular weight subunits are classified as elastomeric proteins, because the glutenin network can withstand significant deformations without breaking, and return to the original conformation when the stress is removed. Elastomeric proteins differ considerably in amino acid sequence, but they are all polymers whose subunits consist of elastomeric domains, composed of repeated motifs, and non-elastic domains that mediate cross-linking between the subunits. The elastomeric domain motifs are all rich in glycine residues in addition to other hydrophobic residues. High molecular weight glutenin subunits have an extensive central elastomeric domain, flanked by two terminal non-elastic domains that form disulphide cross-links. The central elastomeric domain is characterized by the following three repeated motifs: PGQGQQ, GYYPTS[P/L]QQ, GQQ. It possesses overlapping beta-turns within and between the repeated motifs, and assumes a regular helical secondary structure with a diameter of approx. 1.9 nm and a pitch of approx. 1.5 nm.
Pssm-ID: 367362 [Multi-domain] Cd Length: 786 Bit Score: 43.40 E-value: 9.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 14 GQPQP-IYPGYHQSSYGGQSGSTaPAIPYGAYNGPVPGYQQTPPQGMSRAPPSSGAPPASTAQA--PCGQAAYGQFGQGD 90
Cdd:pfam03157 276 GQGQQgYYPTSLQQPGQGQSGYY-PTSQQQAGQLQQEQQLGQEQQDQQPGQGRQGQQPGQGQQGqqPAQGQQPGQGQPGY 354
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 91 VQNGPSSTVQMQrlPGSQPfGSPLAPVGNQPPVLQPYGPPPTSAQVATQLSGMQISGAVAP-----APPSSGLG---FGP 162
Cdd:pfam03157 355 YPTSPQQPGQGQ--PGYYP-TSQQQPQQGQQPEQGQQGQQQGQGQQGQQPGQGQQPGQGQPgyyptSPQQSGQGqpgYYP 431
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 163 PTSLASASGSFPNSGLY---GSYPQGQAPPLSQAQGHPGiQTPQRSAPSQASSFTPPASggprlPSMTGPLLPGQSFGGP 239
Cdd:pfam03157 432 TSPQQSGQGQQPGQGQQpgqEQPGQGQQPGQGQQGQQPG-QPEQGQQPGQGQPGYYPTS-----PQQSGQGQQLGQWQQQ 505
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 767964335 240 SVSQPNHVSSPPQALPPGTQMTGPLGPLPPmhspqqpGYQPQQNGSFGPARGPQSNYGG 298
Cdd:pfam03157 506 GQGQPGYYPTSPLQPGQGQPGYYPTSPQQP-------GQGQQLGQLQQPTQGQQGQQSG 557
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
4-352 |
1.00e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 43.44 E-value: 1.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 4 NQSVPPVPPFGQPQPIYPGYHQSSYGGQSGSTAPAIPygayngPVPGYQQTPPQGMSRAPPSSGAPPASTAQAPCGQAAY 83
Cdd:PRK07764 429 PQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQ------PAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAA 502
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 84 GQFGQGDVQ------------NGPSSTVQMQRLPGSQPfgsplapVGNQPPVLQPYGPPPTSAQ--------------VA 137
Cdd:PRK07764 503 PAGADDAATlrerwpeilaavPKRSRKTWAILLPEATV-------LGVRGDTLVLGFSTGGLARrfaspgnaevlvtaLA 575
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 138 TQLSG-MQISGAVAPAPPSSGLGFGPPTSLASASGSFPNSGLYGSYPQGQAPPLSQAQGHPGIQTPQRSAPSQASSFTPP 216
Cdd:PRK07764 576 EELGGdWQVEAVVGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPK 655
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 217 ASGGPRLPSMTGP---LLPGQSFGGPSVSQPNHVSSPPQALPPGTQMTGPLGPLPPMHSPQQPGYQPQQNGSFGPaRGPQ 293
Cdd:PRK07764 656 HVAVPDASDGGDGwpaKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASA-PSPA 734
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 767964335 294 SNYGGPYPAAPTFGSQPGPPQPLPPKRLDPDAIPSPQLSELPPQQKTRHRIDPDAIPSP 352
Cdd:PRK07764 735 ADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAEDDAPSM 793
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
8-269 |
1.20e-03 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 43.24 E-value: 1.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 8 PPVPPFGQPQPIYPGYHQSSYGGQSGStaPAIPYGAYNGPVPGyqqtppqGMSRAPPSSGAPPASTAQAP-CGQAAYGQF 86
Cdd:PHA03307 185 APSSPPAEPPPSTPPAAASPRPPRRSS--PISASASSPAPAPG-------RSAADDAGASSSDSSSSESSgCGWGPENEC 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 87 GQGDVQNGPSSTVQMQRLPG---------SQPFGSPLAPVGNQPPVLQPYGPPPTSAQVATQLSGMQISGAVAPA---PP 154
Cdd:PHA03307 256 PLPRPAPITLPTRIWEASGWngpssrpgpASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSsssES 335
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 155 SSGLGFGPPTSLASASGSFPNSGlygsyPQGQAPPLSQAQGHPGIQTPQRSAPSQASSFTPPASGGPRLPSMTGPLLPGQ 234
Cdd:PHA03307 336 SRGAAVSPGPSPSRSPSPSRPPP-----PADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAG 410
|
250 260 270
....*....|....*....|....*....|....*...
gi 767964335 235 SFGGPSVSQPNHVSSPPQALPPGTQMTGPL---GPLPP 269
Cdd:PHA03307 411 RPRPSPLDAGAASGAFYARYPLLTPSGEPWpgsPPPPP 448
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
28-336 |
1.27e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 43.05 E-value: 1.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 28 YGGQSGSTAPAIPYGAYNGPVPgyqqTPPQGMSRAPPSSGAPPASTAQAPCGQAAygqfgqgdvqnGPSSTVQMQRLPGS 107
Cdd:PRK07764 387 VAGGAGAPAAAAPSAAAAAPAA----APAPAAAAPAAAAAPAPAAAPQPAPAPAP-----------APAPPSPAGNAPAG 451
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 108 QPFGSPLAPVGNQPPVLQPYGPPPTSAQVATQLSGMQISGAVAPAPPSSGLGFGPPT------------------SLASA 169
Cdd:PRK07764 452 GAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDaatlrerwpeilaavpkrSRKTW 531
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 170 SGSFPNSGLYGsyPQGQA-------PPLSQA---QGHPGI-------QTPQRSAPSQASSFTPPASGGPRLPSMTGPLLP 232
Cdd:PRK07764 532 AILLPEATVLG--VRGDTlvlgfstGGLARRfasPGNAEVlvtalaeELGGDWQVEAVVGPAPGAAGGEGPPAPASSGPP 609
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 233 GQSFGGPSVSQPnhvSSPPQALPPGTQMTGPLGPLPPMHSPQQPGYQPQQNGSFGPARGPQSNYGGPYPAAPTFGSQPGP 312
Cdd:PRK07764 610 EEAARPAAPAAP---AAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPA 686
|
330 340
....*....|....*....|....
gi 767964335 313 PQPLPPKRLDPDAIPSPQLSELPP 336
Cdd:PRK07764 687 PAAPAAPAGAAPAQPAPAPAATPP 710
|
|
| SPT5 |
COG5164 |
Transcription elongation factor SPT5 [Transcription]; |
87-418 |
1.30e-03 |
|
Transcription elongation factor SPT5 [Transcription];
Pssm-ID: 444063 [Multi-domain] Cd Length: 495 Bit Score: 42.71 E-value: 1.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 87 GQGDVQNGPSSTVQMQRLPGSQPFGSPLAPVGNQPPvlqpygppptsAQVATQLSGMQISGAVAPAPPSSGlgfGPPTSL 166
Cdd:COG5164 3 LYGPGKTGPSDPGGVTTPAGSQGSTKPAQNQGSTRP-----------AGNTGGTRPAQNQGSTTPAGNTGG---TRPAGN 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 167 ASASGSFPNSGlygsypqGQAPPlsqaqGHPGIQTPqrsaPSQASSFTPPASGGPrlpsmTGPLLPGQSFGGP----SVS 242
Cdd:COG5164 69 QGATGPAQNQG-------GTTPA-----QNQGGTRP----AGNTGGTTPAGDGGA-----TGPPDDGGATGPPddggSTT 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 243 QPNHVSSPPQ----ALPPGTQMTGPLGPLPPmHSPQQPGYQPQQNGSFGPAR-------------GPQSNYGGPYPAAPT 305
Cdd:COG5164 128 PPSGGSTTPPgdggSTPPGPGSTGPGGSTTP-PGDGGSTTPPGPGGSTTPPDdggsttppnkgetGTDIPTGGTPRQGPD 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 306 FGSQPGPPQPLPPKRLDPDAI--PSPQLSELPPQQKTRhRIDPDAIPSPIQVIeddrNNRGTEPFVTGVR-GQVPPLVTT 382
Cdd:COG5164 207 GPVKKDDKNGKGNPPDDRGGKtgPKDQRPKTNPIERRG-PERPEAAALPAELT----ALEAENRAANPEPaTKTIPETTT 281
|
330 340 350
....*....|....*....|....*....|....*.
gi 767964335 383 nflVKDQGNASPRYIRCTSYNIPCTSDMAKQAQVPL 418
Cdd:COG5164 282 ---VKDLATVLGKKGSDLVTNLMKKGKGTNINAALD 314
|
|
| PRK14959 |
PRK14959 |
DNA polymerase III subunits gamma and tau; Provisional |
146-255 |
1.47e-03 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 184923 [Multi-domain] Cd Length: 624 Bit Score: 42.74 E-value: 1.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 146 SGAVAPAPPSSGLGFGPPTSLASASGSFPNSGLYGSYPQGQAPPLSQAqghPGIQTPQRSAPSqassfTPPASGGPRLPS 225
Cdd:PRK14959 382 SGSAAEGPASGGAATIPTPGTQGPQGTAPAAGMTPSSAAPATPAPSAA---PSPRVPWDDAPP-----APPRSGIPPRPA 453
|
90 100 110
....*....|....*....|....*....|
gi 767964335 226 mtgPLLPGQSfggPSVSQPNHVSSPPQALP 255
Cdd:PRK14959 454 ---PRMPEAS---PVPGAPDSVASASDAPP 477
|
|
| SP6_N |
cd22544 |
N-terminal domain of transcription factor Specificity Protein (SP) 6; Specificity Proteins ... |
105-266 |
2.78e-03 |
|
N-terminal domain of transcription factor Specificity Protein (SP) 6; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. SP6, also known as epiprofin, shows specific expression pattern in hair follicles and the apical ectodermal ridge (AER) of the developing limbs. SP6 null mice are nude and show defects in skin, teeth, limbs (syndactyly and oligodactyly), and lung alveoli. SP6 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. This model represents the N-terminal domain of SP6.
Pssm-ID: 411693 [Multi-domain] Cd Length: 245 Bit Score: 40.67 E-value: 2.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 105 PGSQPFGSPlAPVGNQPpvLQPYGPPPTSAQVATQLSGMQISGAVAPAPP----SSGLGFGPPTSLASASGSFPNSGLyG 180
Cdd:cd22544 13 HSETPRASP-PTLDLQP--LQPYQIHSSPEAGDYPSPLQPTELQSLPLGPgvdfSARESYEPHSSRRTCLDLESDLPL-G 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 181 SYPQGQAPPLSQAQ--------GHPGIQTPQRSAPS-----QASSFT--PPASGGPRLPSMTGPLLPGQsfgGPSVSQPN 245
Cdd:cd22544 89 PFPKLLHPPPDMAHpyeswfrpPHPGGSGEEGGVPSwwdlhAGSSWMdlQHGQGGLQSPGPPGGLQPPL---GGYGSEHQ 165
|
170 180
....*....|....*....|.
gi 767964335 246 HVSSPPQALPPGTQMTGPLGP 266
Cdd:cd22544 166 LCGPPHHLLPPAQHLMGQEGP 186
|
|
| PPE |
COG5651 |
PPE-repeat protein [Function unknown]; |
129-308 |
2.78e-03 |
|
PPE-repeat protein [Function unknown];
Pssm-ID: 444372 [Multi-domain] Cd Length: 385 Bit Score: 41.42 E-value: 2.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 129 PPPTSAQVATQLSGMQISGAVAPAPPSSGLGFGPPTSLASASGSFPNSGLYGSYPQGQAPPLSQAQGHPGIQTPQRSAPS 208
Cdd:COG5651 166 PFTQPPPTITNPGGLLGAQNAGSGNTSSNPGFANLGLTGLNQVGIGGLNSGSGPIGLNSGPGNTGFAGTGAAAGAAAAAA 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 209 QASSF-TPPASGGPRLPSMTGPLLPGQSFGGPSVSQPNHVSSPPQALPPGTQMTGPLGPLPPMHSPQQPGYQPQQNGSFG 287
Cdd:COG5651 246 AAAAAaGAGASAALASLAATLLNASSLGLAATAASSAATNLGLAGSPLGLAGGGAGAAAATGLGLGAGGAAGAAGATGAG 325
|
170 180
....*....|....*....|.
gi 767964335 288 PARGPQSNYGGPYPAAPTFGS 308
Cdd:COG5651 326 AALGAGAAAAAAGAAAGAGAA 346
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
3-220 |
3.76e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 41.40 E-value: 3.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 3 VNQSVPPV--PPFGQPQPIYPGYHQSSYGGQSGSTAPAIPYGAYNGPVPGYQQTPPQGMSRAPPSSGAPPASTAQAPCGQ 80
Cdd:PRK12323 382 VAQPAPAAaaPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPAAA 461
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 81 ---AAYGQFGQGDVQNGPSSTVQMQRLPGSQPFGSPlaPVGNQPPVLQPYGPPPTsaqvatqlsgmqisgavAPAPPSSG 157
Cdd:PRK12323 462 arpAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPP--PWEELPPEFASPAPAQP-----------------DAAPAGWV 522
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767964335 158 LGFGPPTSLASASGSFPNSGlygsyPQGQAPPLSQAQGHPGIQTPQRsAPSQASSFTPPASGG 220
Cdd:PRK12323 523 AESIPDPATADPDDAFETLA-----PAPAAAPAPRAAAATEPVVAPR-PPRASASGLPDMFDG 579
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
67-269 |
3.96e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 41.40 E-value: 3.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 67 GAPPASTAQAPCGQAAYGQFGQGDVQNGPSStvqmqrlPGSQPFGSPLAPVGNQPPVLQPYGPPPTSAQVATQLSGMQIS 146
Cdd:PRK12323 371 GAGPATAAAAPVAQPAPAAAAPAAAAPAPAA-------PPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARG 443
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 147 GAVAPAPPSSglgfgPPTSLASAsgsfpnsglygsypqgQAPPLSQAQGHPGIQTPQRSAPSQASSFTPPASGGP---RL 223
Cdd:PRK12323 444 PGGAPAPAPA-----PAAAPAAA----------------ARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPpweEL 502
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 767964335 224 PSMTGPLLPGQSFGGPSVSQPNHVSSPPQALPPGTQMTGPLGPLPP 269
Cdd:PRK12323 503 PPEFASPAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAA 548
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
29-360 |
4.25e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 41.12 E-value: 4.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 29 GGQSGSTAPAIPYGAYNGPVPGYQQTPPQGM--SRAPPSSGAPPASTAQAPCGQAAYGQFGQGDVQNGPSSTVQMQRLPG 106
Cdd:PRK07764 390 GAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAaaPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPA 469
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 107 SQPFGSPLAPVGNQPPVLQPYGPPPTSAQVATQLSGMQ----------------------ISGAVAPAP----------- 153
Cdd:PRK07764 470 PAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADdaatlrerwpeilaavpkrsrkTWAILLPEAtvlgvrgdtlv 549
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 154 ---PSSGLG-----------------------------FGPPTSLASASGSfPNSGLYGSYPQGQAPplsQAQGHPGiQT 201
Cdd:PRK07764 550 lgfSTGGLArrfaspgnaevlvtalaeelggdwqveavVGPAPGAAGGEGP-PAPASSGPPEEAARP---AAPAAPA-AP 624
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 202 PQRSAPSQASSFTPPASGGPRLPSMTGPLLPGQSFGGPSvSQPNHVSSPPQALPPGTQMTGPLGPLPPMHSPQQPGYQPQ 281
Cdd:PRK07764 625 AAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDAS-DGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAP 703
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 282 QNGSFGPARGPQSNYGGPYPAAPTFGSQPGPPQPLPPKRLDPDA--IPSPQLSELPPQQKTRHRIDPDAIPSPIQVIEDD 359
Cdd:PRK07764 704 APAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDppDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEE 783
|
.
gi 767964335 360 R 360
Cdd:PRK07764 784 E 784
|
|
| Treacle |
pfam03546 |
Treacher Collins syndrome protein Treacle; |
52-433 |
4.32e-03 |
|
Treacher Collins syndrome protein Treacle;
Pssm-ID: 460967 [Multi-domain] Cd Length: 531 Bit Score: 41.21 E-value: 4.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 52 QQTPPQGMSRAPPSSGAPPASTAQAPcgqAAYGQFGQGDVQNGPSSTVQMQRLPGSQPFGSPLA-PVGNQPPVLQPYGPp 130
Cdd:pfam03546 129 QVRPASTVGKGPSGKGANPAPPGKAG---SAAPLVQVGKKEEDSESSSEESDSEGEAPPAATQAkPSGKILQVRPASGP- 204
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 131 ptsaqvatqlsgmqiSGAVAPAPPSSGlgfGPPTSLASASGSFPNSGLY--GSYPQGQAPP-LSQAQGHPGIQTPQRSA- 206
Cdd:pfam03546 205 ---------------AKGAAPAPPQKA---GPVATQVKAERSKEDSESSeeSSDSEEEAPAaATPAQAKPALKTPQTKAs 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 207 PSQASSFTP-PASGGPRLPSMTGPLLPGqsfggpSVSQPNHVSSPpqALPPGTQMtgplgplPPMHSPQQPGYQPQQNGS 285
Cdd:pfam03546 267 PRKGTPITPtSAKVPPVRVGTPAPWKAG------TVTSPACASSP--AVARGAQR-------PEEDSSSSEESESEEETA 331
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 286 FGPARGPQSNYGGPYPAAPTfgsqpgppqplppkrLDPDAIPSPQLSELPPQQKTRhridPDAIPSPIQVIEDDRNNR-- 363
Cdd:pfam03546 332 PAAAVGQAKSVGKGLQGKAA---------------SAPTKGPSGQGTAPVPPGKTG----PAVAQVKAEAQEDSESSEee 392
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767964335 364 -GTEPfVTGVRGQVPPLVTTNflvkdQGNASPRYIRCTSYNIPCTS-----DMAKQAQVPLAAVIKPLARLPPEEA 433
Cdd:pfam03546 393 sDSEE-AAATPAQVKASGKTP-----QAKANPAPTKASSAKGAASApgkvvAAAAQAKQGSPAKVKPPARTPQNSA 462
|
|
| Glutenin_hmw |
pfam03157 |
High molecular weight glutenin subunit; Members of this family include high molecular weight ... |
8-307 |
4.32e-03 |
|
High molecular weight glutenin subunit; Members of this family include high molecular weight subunits of glutenin. This group of gluten proteins is thought to be largely responsible for the elastic properties of gluten, and hence, doughs. Indeed, glutenin high molecular weight subunits are classified as elastomeric proteins, because the glutenin network can withstand significant deformations without breaking, and return to the original conformation when the stress is removed. Elastomeric proteins differ considerably in amino acid sequence, but they are all polymers whose subunits consist of elastomeric domains, composed of repeated motifs, and non-elastic domains that mediate cross-linking between the subunits. The elastomeric domain motifs are all rich in glycine residues in addition to other hydrophobic residues. High molecular weight glutenin subunits have an extensive central elastomeric domain, flanked by two terminal non-elastic domains that form disulphide cross-links. The central elastomeric domain is characterized by the following three repeated motifs: PGQGQQ, GYYPTS[P/L]QQ, GQQ. It possesses overlapping beta-turns within and between the repeated motifs, and assumes a regular helical secondary structure with a diameter of approx. 1.9 nm and a pitch of approx. 1.5 nm.
Pssm-ID: 367362 [Multi-domain] Cd Length: 786 Bit Score: 41.09 E-value: 4.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 8 PPVPPFGQPQPIYPGYHQSSYGGQSGSTAPAIPYGAYNGPVPGYQQT---PPQGMSRAPPSSGAP---PASTAQAPCGQ- 80
Cdd:pfam03157 419 PQQSGQGQPGYYPTSPQQSGQGQQPGQGQQPGQEQPGQGQQPGQGQQgqqPGQPEQGQQPGQGQPgyyPTSPQQSGQGQq 498
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 81 -AAYGQFGQGDVQNGPSSTVQM-QRLPGSQPFGSPLAPVGNQPPVLQPYGPPPTSAQVATQLSGMQISGAVAPAPPSSGL 158
Cdd:pfam03157 499 lGQWQQQGQGQPGYYPTSPLQPgQGQPGYYPTSPQQPGQGQQLGQLQQPTQGQQGQQSGQGQQGQQPGQGQQGQQPGQGQ 578
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 159 GFGPPtslasASGSFPNSGLYGSYP-------QGQAPPLSQ--AQGHPGIQTPQRSAPSQASSFTPPAS----GGPRLPS 225
Cdd:pfam03157 579 QGQQP-----GQGQQPGQGQPGYYPtspqqsgQGQQPGQWQqpGQGQPGYYPTSSLQLGQGQQGYYPTSpqqpGQGQQPG 653
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 226 MTGPLLPGQSFGGP-------SVSQPNHVSSPPQALPPGTQMTG--PLGPLPPmhspqqpGYQPQQNGSFGPARGPQsny 296
Cdd:pfam03157 654 QWQQSGQGQQGYYPtspqqsgQAQQPGQGQQPGQWLQPGQGQQGyyPTSPQQP-------GQGQQLGQGQQSGQGQQ--- 723
|
330
....*....|.
gi 767964335 297 gGPYPAAPTFG 307
Cdd:pfam03157 724 -GYYPTSPGQG 733
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
103-239 |
4.82e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 41.12 E-value: 4.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 103 RLPGSQPFGSPLAPVGNQPPVLQPYGPPPTSAQVATQLSGMQISGAVAPAPPSSGLgfGPPTSLASASGSFPNSGLYGSY 182
Cdd:PRK07764 380 RLERRLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAP--APAPAPPSPAGNAPAGGAPSPP 457
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 767964335 183 PQGQAPPLSQAQGHPGIQTPQRSAPSQASSFTPPASggPRLPSMTGPLLPGQSFGGP 239
Cdd:PRK07764 458 PAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAA--PAAPAAPAAPAGADDAATL 512
|
|
| PHA03379 |
PHA03379 |
EBNA-3A; Provisional |
118-352 |
7.17e-03 |
|
EBNA-3A; Provisional
Pssm-ID: 223066 [Multi-domain] Cd Length: 935 Bit Score: 40.43 E-value: 7.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 118 GNQPPVLQPYGPPPTSAQVATQLSGMQisgaVAPAPPSSGLGFGPptsLASASGSFPnsGLYGSYPQGQAPPLSQAQGHP 197
Cdd:PHA03379 415 TPRPPVEKPRPEVPQSLETATSHGSAQ----VPEPPPVHDLEPGP---LHDQHSMAP--CPVAQLPPGPLQDLEPGDQLP 485
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 198 GIQTPQRSAPSQAssftpPASGGPRL-PSMTGPL-LPGQSFGgPSVSQPNHVSSPPQalpPGTQMTGPLGPLPP---MHS 272
Cdd:PHA03379 486 GVVQDGRPACAPV-----PAPAGPIVrPWEASLSqVPGVAFA-PVMPQPMPVEPVPV---PTVALERPVCPAPPliaMQG 556
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 273 PQQPGYQPQQNGSFGPA----RGPQSNYGGPYPAAPTFGSQPGPPqplppkRLDPDAIPSPQLSELPPQQKTRHRIDPDA 348
Cdd:PHA03379 557 PGETSGIVRVRERWRPApwtpNPPRSPSQMSVRDRLARLRAEAQP------YQASVEVQPPQLTQVSPQQPMEYPLEPEQ 630
|
....
gi 767964335 349 IPSP 352
Cdd:PHA03379 631 QMFP 634
|
|
| PHA02682 |
PHA02682 |
ORF080 virion core protein; Provisional |
132-268 |
7.29e-03 |
|
ORF080 virion core protein; Provisional
Pssm-ID: 177464 [Multi-domain] Cd Length: 280 Bit Score: 39.84 E-value: 7.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 132 TSAQVATQLSGMQISGAVAPAPPSSGLGFGPPTSLASAsGSFPNSGLYGSY-----PQGQAP-PLSQAQGHPGIQTPQRS 205
Cdd:PHA02682 21 TSSSLFTKCPQATIPAPAAPCPPDADVDPLDKYSVKEA-GRYYQSRLKANSacmqrPSGQSPlAPSPACAAPAPACPACA 99
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767964335 206 APSQASSFTPPASgGPRLPSMTGPLLPgqsfggPSVSQPNHvSSPPQALPPGTQMTGPLGPLP 268
Cdd:PHA02682 100 PAAPAPAVTCPAP-APACPPATAPTCP------PPAVCPAP-ARPAPACPPSTRQCPPAPPLP 154
|
|
| DUF4645 |
pfam15488 |
Domain of unknown function (DUF4645); This family of proteins is found in eukaryotes. Proteins ... |
116-305 |
8.04e-03 |
|
Domain of unknown function (DUF4645); This family of proteins is found in eukaryotes. Proteins in this family are typically between 200 and 298 amino acids in length.
Pssm-ID: 406050 [Multi-domain] Cd Length: 294 Bit Score: 39.46 E-value: 8.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 116 PVGNQPPVLQPYGPPPTSAQ--VATQ-------LSG--------MQISGAVAPAPPSSGLGfGPPTSLASASGSFPNSGL 178
Cdd:pfam15488 82 PVDSSRALRHPYGPPPAVAEesLATAevnssegLAGwrqkgqdsINVSQEFSGSPPALMVG-GTRVSNGGTERGGNNAKL 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964335 179 YGSYPQGQA---PPLSQAQGHPGIQTPQRSAPSQASSFTPPASGGPRLPSMTGPLlpgqsfGGPSvsqpNHVSSPPQALP 255
Cdd:pfam15488 161 YSALPRGQGffpPRGPQVRGPPHIPTLRSGIMMEVPPGNTRMAGKERLAHVSFPL------GGPR----HPMDNWPRPIP 230
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 767964335 256 PGTQMTGpLGPLPPMHspqqpgyqpqqngSFGPARGPQSNyggPYPAAPT 305
Cdd:pfam15488 231 LSSSTPG-LPSCSTAH-------------CFIPPRPPSFN---PFLAMPI 263
|
|
| |
