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Conserved domains on  [gi|795441033|ref|XP_011885150|]
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PREDICTED: SUN domain-containing protein 1 isoform X17 [Cercocebus atys]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sad1_UNC pfam07738
Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that ...
 648-783 7.83e-59

Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that is involved in nuclear anchoring and migration during development. The S. pombe Sad1 protein localizes at the spindle pole body. UNC-84 and and Sad1 share a common C-terminal region, that is often termed the SUN (Sad1 and UNC) domain. In mammals, the SUN domain is present in two proteins, Sun1 and Sun2. The SUN domain of Sun2 has been demonstrated to be in the periplasm.


:

Pssm-ID: 400199  Cd Length: 130  Bit Score: 195.59  E-value: 7.83e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795441033  648 LWYFSQSPRVVIQPDIYPGNCWAFKGSQGYLVVRLSMMIHPAAFTLEHIPKTLsptgnISSAPKDFAVYGLENEYQEEGQ 727
Cdd:pfam07738   1 LNYEAKPPKVILQPDYMPGPCWSFKGSRGFVVIELSEFIIVEAITLEHVEKSV-----FSSAPKDFEVSGSDRYPTTKWV 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 795441033  728 LLGQFTYDQDGESLQMFQALKTPDDrVFQIVELRIFSNWGHPEYTCLYRFRVHGEP 783
Cdd:pfam07738  76 LLGEFSYDLDGKTIQTFQLENPPDI-WVKYVKLRILSNYGNEHYTCLYRFRVHGTV 130
MRP pfam09387
Mitochondrial RNA binding protein MRP; MRP1 and MRP2 are mitochondrial RNA binding proteins ...
 82-291 4.77e-54

Mitochondrial RNA binding protein MRP; MRP1 and MRP2 are mitochondrial RNA binding proteins that form a heteromeric complex. The MRP1/MRP2 heterotetrameric complex binds to guide RNAs and stabilizes them in an unfolded conformation suitable for RNA-RNA hybridization. Each MRP subunit adopts a 'whirly' transcription factor fold.


:

Pssm-ID: 430576  Cd Length: 192  Bit Score: 185.15  E-value: 4.77e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795441033   82 SLKNRAARTAKQCRSTNKSAFSINHVSRQVTSFGvshsgtdslqdavtrqppvldeSWIReQTTVDHFWGLD----DDGD 157
Cdd:pfam09387  21 SWRDRAARTQKQRRSASPPAFDIVHWSRKDISSG----------------------SLIR-QTKVDHFWGLDyhlpDDGD 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795441033  158 LKGGNKAAIQGNGDLGAAAATAhNGFSCSNCSMLSERkdvLTAHPAAPGPVSRVYSRDRNQKRYFLLQTLRRIGAAGRAV 237
Cdd:pfam09387  78 LKGGPKAAPQGNGDRAVSVALP-NGYTARFCSVLEGR---LTKHEVASGPTNRVFSRDRAQKNTYTLKCTSTKPAQGQSQ 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 795441033  238 SRTAwsalwlavvapGKAASGVFWWLgigwYQFVTLISWLNVFLLTRCLRNICK 291
Cdd:pfam09387 154 RSNA-----------GKAASEVFEWL----VQFVTLESWLNVFFLTRALRNICG 192
SUN1_cc1 cd21439
coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins; SUN ...
 417-470 9.21e-28

coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins; SUN domain-containing protein 1 (SUN1), also called protein unc-84 homolog A, or Sad1/unc-84 protein-like 1, is a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex which is involved in the connection between the nuclear lamina and the cytoskeleton. Besides the core SUN domain, SUN1 contains two coiled-coil domains (CC1 and CC2), which act as the intrinsic dynamic regulators for controlling the activity of the SUN domain. This model corresponds to CC1 that may function as an activation segment to release CC2-mediated inhibition of the SUN domain.


:

Pssm-ID: 410605 [Multi-domain]  Cd Length: 55  Bit Score: 106.21  E-value: 9.21e-28
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 795441033 417 QPLKETDFMAFHQEHEVRISHLEDILGKLREKSEAIQKELEQTKQKTVSAVGEQ 470
Cdd:cd21439    1 QPLSQTDFMAFHQEHELRISNLEDLLGKLSEKSEAIQKELEQTKLRTASGADEQ 54
HTH_SUN2 super family cl39899
SUN2 helix-turn-helix domain; LINC complexes are formed by coupling of KASH (Klarsicht, ANC-1, ...
 547-605 1.52e-07

SUN2 helix-turn-helix domain; LINC complexes are formed by coupling of KASH (Klarsicht, ANC-1, and Syne/Nesprin Homology) and SUN (Sad1 and UNC-84) proteins from the inner and outer nuclear membranes (INM and ONM, respectively). the formation of LINC complexes by KASH and SUN proteins at the nuclear envelope (NE) establishes the physical linkage between the cytoskeleton and nuclear lamina, which is instrumental for the mechanical force transmission from the cytoplasm to the nuclear interior, and is essential for cellular processes such as nuclear positioning and migration, centrosome-nucleus anchorage, and chromosome dynamics. This entry represents an HTH domain found in SUN2 that forms a three-helix bundle to lock the SUN domain in an inactive conformation acting as an inhibitory component.


The actual alignment was detected with superfamily member pfam18580:

Pssm-ID: 436594 [Multi-domain]  Cd Length: 58  Bit Score: 48.87  E-value: 1.52e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 795441033  547 LHTMLRDLELQILRNVTHHISVTKRlPASEVVVSAVSEAGASGITEAQARAIVNNALKL 605
Cdd:pfam18580   1 LQAQLQDLEQRILAKLAEEQGKSAR-DAAASVGVALQQEGVTGVTEEQVHRIVNQALKR 58
CALCOCO1 super family cl37761
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 366-539 1.02e-03

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


The actual alignment was detected with superfamily member pfam07888:

Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 42.57  E-value: 1.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795441033  366 EQQVTSLSGQCHHHGENLRELTTLLQKLQARvdQMDNGAAGPSTSvrdavgqplKETD-FMAFHQEHEVRISHLEDILGK 444
Cdd:pfam07888  72 ERQRRELESRVAELKEELRQSREKHEELEEK--YKELSASSEELS---------EEKDaLLAQRAAHEARIRELEEDIKT 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795441033  445 LREKSEAIQKELEQTKQKTVSAVGEQLLPTVEH--LQLELDQLKSELsswRHMKTGCETVDALQERVDVQV---RETV-- 517
Cdd:pfam07888 141 LTQRVLERETELERMKERAKKAGAQRKEEEAERkqLQAKLQQTEEEL---RSLSKEFQELRNSLAQRDTQVlqlQDTItt 217

                         170       180
                  ....*....|....*....|....
gi 795441033  518 --KLLFSEDQQGGSLEQLLQRFSS 539
Cdd:pfam07888 218 ltQKLTTAHRKEAENEALLEELRS 241
 
Name Accession Description Interval E-value
Sad1_UNC pfam07738
Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that ...
 648-783 7.83e-59

Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that is involved in nuclear anchoring and migration during development. The S. pombe Sad1 protein localizes at the spindle pole body. UNC-84 and and Sad1 share a common C-terminal region, that is often termed the SUN (Sad1 and UNC) domain. In mammals, the SUN domain is present in two proteins, Sun1 and Sun2. The SUN domain of Sun2 has been demonstrated to be in the periplasm.


Pssm-ID: 400199  Cd Length: 130  Bit Score: 195.59  E-value: 7.83e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795441033  648 LWYFSQSPRVVIQPDIYPGNCWAFKGSQGYLVVRLSMMIHPAAFTLEHIPKTLsptgnISSAPKDFAVYGLENEYQEEGQ 727
Cdd:pfam07738   1 LNYEAKPPKVILQPDYMPGPCWSFKGSRGFVVIELSEFIIVEAITLEHVEKSV-----FSSAPKDFEVSGSDRYPTTKWV 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 795441033  728 LLGQFTYDQDGESLQMFQALKTPDDrVFQIVELRIFSNWGHPEYTCLYRFRVHGEP 783
Cdd:pfam07738  76 LLGEFSYDLDGKTIQTFQLENPPDI-WVKYVKLRILSNYGNEHYTCLYRFRVHGTV 130
MRP pfam09387
Mitochondrial RNA binding protein MRP; MRP1 and MRP2 are mitochondrial RNA binding proteins ...
 82-291 4.77e-54

Mitochondrial RNA binding protein MRP; MRP1 and MRP2 are mitochondrial RNA binding proteins that form a heteromeric complex. The MRP1/MRP2 heterotetrameric complex binds to guide RNAs and stabilizes them in an unfolded conformation suitable for RNA-RNA hybridization. Each MRP subunit adopts a 'whirly' transcription factor fold.


Pssm-ID: 430576  Cd Length: 192  Bit Score: 185.15  E-value: 4.77e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795441033   82 SLKNRAARTAKQCRSTNKSAFSINHVSRQVTSFGvshsgtdslqdavtrqppvldeSWIReQTTVDHFWGLD----DDGD 157
Cdd:pfam09387  21 SWRDRAARTQKQRRSASPPAFDIVHWSRKDISSG----------------------SLIR-QTKVDHFWGLDyhlpDDGD 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795441033  158 LKGGNKAAIQGNGDLGAAAATAhNGFSCSNCSMLSERkdvLTAHPAAPGPVSRVYSRDRNQKRYFLLQTLRRIGAAGRAV 237
Cdd:pfam09387  78 LKGGPKAAPQGNGDRAVSVALP-NGYTARFCSVLEGR---LTKHEVASGPTNRVFSRDRAQKNTYTLKCTSTKPAQGQSQ 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 795441033  238 SRTAwsalwlavvapGKAASGVFWWLgigwYQFVTLISWLNVFLLTRCLRNICK 291
Cdd:pfam09387 154 RSNA-----------GKAASEVFEWL----VQFVTLESWLNVFFLTRALRNICG 192
SUN1_cc1 cd21439
coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins; SUN ...
 417-470 9.21e-28

coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins; SUN domain-containing protein 1 (SUN1), also called protein unc-84 homolog A, or Sad1/unc-84 protein-like 1, is a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex which is involved in the connection between the nuclear lamina and the cytoskeleton. Besides the core SUN domain, SUN1 contains two coiled-coil domains (CC1 and CC2), which act as the intrinsic dynamic regulators for controlling the activity of the SUN domain. This model corresponds to CC1 that may function as an activation segment to release CC2-mediated inhibition of the SUN domain.


Pssm-ID: 410605 [Multi-domain]  Cd Length: 55  Bit Score: 106.21  E-value: 9.21e-28
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 795441033 417 QPLKETDFMAFHQEHEVRISHLEDILGKLREKSEAIQKELEQTKQKTVSAVGEQ 470
Cdd:cd21439    1 QPLSQTDFMAFHQEHELRISNLEDLLGKLSEKSEAIQKELEQTKLRTASGADEQ 54
HTH_SUN2 pfam18580
SUN2 helix-turn-helix domain; LINC complexes are formed by coupling of KASH (Klarsicht, ANC-1, ...
 547-605 1.52e-07

SUN2 helix-turn-helix domain; LINC complexes are formed by coupling of KASH (Klarsicht, ANC-1, and Syne/Nesprin Homology) and SUN (Sad1 and UNC-84) proteins from the inner and outer nuclear membranes (INM and ONM, respectively). the formation of LINC complexes by KASH and SUN proteins at the nuclear envelope (NE) establishes the physical linkage between the cytoskeleton and nuclear lamina, which is instrumental for the mechanical force transmission from the cytoplasm to the nuclear interior, and is essential for cellular processes such as nuclear positioning and migration, centrosome-nucleus anchorage, and chromosome dynamics. This entry represents an HTH domain found in SUN2 that forms a three-helix bundle to lock the SUN domain in an inactive conformation acting as an inhibitory component.


Pssm-ID: 436594 [Multi-domain]  Cd Length: 58  Bit Score: 48.87  E-value: 1.52e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 795441033  547 LHTMLRDLELQILRNVTHHISVTKRlPASEVVVSAVSEAGASGITEAQARAIVNNALKL 605
Cdd:pfam18580   1 LQAQLQDLEQRILAKLAEEQGKSAR-DAAASVGVALQQEGVTGVTEEQVHRIVNQALKR 58
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 366-539 1.02e-03

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 42.57  E-value: 1.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795441033  366 EQQVTSLSGQCHHHGENLRELTTLLQKLQARvdQMDNGAAGPSTSvrdavgqplKETD-FMAFHQEHEVRISHLEDILGK 444
Cdd:pfam07888  72 ERQRRELESRVAELKEELRQSREKHEELEEK--YKELSASSEELS---------EEKDaLLAQRAAHEARIRELEEDIKT 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795441033  445 LREKSEAIQKELEQTKQKTVSAVGEQLLPTVEH--LQLELDQLKSELsswRHMKTGCETVDALQERVDVQV---RETV-- 517
Cdd:pfam07888 141 LTQRVLERETELERMKERAKKAGAQRKEEEAERkqLQAKLQQTEEEL---RSLSKEFQELRNSLAQRDTQVlqlQDTItt 217

                         170       180
                  ....*....|....*....|....
gi 795441033  518 --KLLFSEDQQGGSLEQLLQRFSS 539
Cdd:pfam07888 218 ltQKLTTAHRKEAENEALLEELRS 241
 
Name Accession Description Interval E-value
Sad1_UNC pfam07738
Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that ...
 648-783 7.83e-59

Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that is involved in nuclear anchoring and migration during development. The S. pombe Sad1 protein localizes at the spindle pole body. UNC-84 and and Sad1 share a common C-terminal region, that is often termed the SUN (Sad1 and UNC) domain. In mammals, the SUN domain is present in two proteins, Sun1 and Sun2. The SUN domain of Sun2 has been demonstrated to be in the periplasm.


Pssm-ID: 400199  Cd Length: 130  Bit Score: 195.59  E-value: 7.83e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795441033  648 LWYFSQSPRVVIQPDIYPGNCWAFKGSQGYLVVRLSMMIHPAAFTLEHIPKTLsptgnISSAPKDFAVYGLENEYQEEGQ 727
Cdd:pfam07738   1 LNYEAKPPKVILQPDYMPGPCWSFKGSRGFVVIELSEFIIVEAITLEHVEKSV-----FSSAPKDFEVSGSDRYPTTKWV 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 795441033  728 LLGQFTYDQDGESLQMFQALKTPDDrVFQIVELRIFSNWGHPEYTCLYRFRVHGEP 783
Cdd:pfam07738  76 LLGEFSYDLDGKTIQTFQLENPPDI-WVKYVKLRILSNYGNEHYTCLYRFRVHGTV 130
MRP pfam09387
Mitochondrial RNA binding protein MRP; MRP1 and MRP2 are mitochondrial RNA binding proteins ...
 82-291 4.77e-54

Mitochondrial RNA binding protein MRP; MRP1 and MRP2 are mitochondrial RNA binding proteins that form a heteromeric complex. The MRP1/MRP2 heterotetrameric complex binds to guide RNAs and stabilizes them in an unfolded conformation suitable for RNA-RNA hybridization. Each MRP subunit adopts a 'whirly' transcription factor fold.


Pssm-ID: 430576  Cd Length: 192  Bit Score: 185.15  E-value: 4.77e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795441033   82 SLKNRAARTAKQCRSTNKSAFSINHVSRQVTSFGvshsgtdslqdavtrqppvldeSWIReQTTVDHFWGLD----DDGD 157
Cdd:pfam09387  21 SWRDRAARTQKQRRSASPPAFDIVHWSRKDISSG----------------------SLIR-QTKVDHFWGLDyhlpDDGD 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795441033  158 LKGGNKAAIQGNGDLGAAAATAhNGFSCSNCSMLSERkdvLTAHPAAPGPVSRVYSRDRNQKRYFLLQTLRRIGAAGRAV 237
Cdd:pfam09387  78 LKGGPKAAPQGNGDRAVSVALP-NGYTARFCSVLEGR---LTKHEVASGPTNRVFSRDRAQKNTYTLKCTSTKPAQGQSQ 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 795441033  238 SRTAwsalwlavvapGKAASGVFWWLgigwYQFVTLISWLNVFLLTRCLRNICK 291
Cdd:pfam09387 154 RSNA-----------GKAASEVFEWL----VQFVTLESWLNVFFLTRALRNICG 192
SUN1_cc1 cd21439
coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins; SUN ...
 417-470 9.21e-28

coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins; SUN domain-containing protein 1 (SUN1), also called protein unc-84 homolog A, or Sad1/unc-84 protein-like 1, is a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex which is involved in the connection between the nuclear lamina and the cytoskeleton. Besides the core SUN domain, SUN1 contains two coiled-coil domains (CC1 and CC2), which act as the intrinsic dynamic regulators for controlling the activity of the SUN domain. This model corresponds to CC1 that may function as an activation segment to release CC2-mediated inhibition of the SUN domain.


Pssm-ID: 410605 [Multi-domain]  Cd Length: 55  Bit Score: 106.21  E-value: 9.21e-28
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 795441033 417 QPLKETDFMAFHQEHEVRISHLEDILGKLREKSEAIQKELEQTKQKTVSAVGEQ 470
Cdd:cd21439    1 QPLSQTDFMAFHQEHELRISNLEDLLGKLSEKSEAIQKELEQTKLRTASGADEQ 54
SUN_cc1 cd21435
coiled-coil domain 1 of SUN domain-containing proteins; SUN (Sad1 and UNC-84) proteins (SUN1 ...
 417-471 2.81e-23

coiled-coil domain 1 of SUN domain-containing proteins; SUN (Sad1 and UNC-84) proteins (SUN1 and SUN2) are components of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex which is involved in the connection between the nuclear lamina and the cytoskeleton. Besides the core SUN domain, SUN proteins contain two coiled-coil domains (CC1 and CC2), which act as intrinsic dynamic regulators controlling the activity of the SUN domain. The model corresponds to CC1 that functions as an activation segment to release CC2-mediated inhibition of the SUN domain.


Pssm-ID: 410603 [Multi-domain]  Cd Length: 55  Bit Score: 93.24  E-value: 2.81e-23
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 795441033 417 QPLKETDFMAFHQEHEVRISHLEDILGKLREKSEAIQKELEQTKQKTVSAVGEQL 471
Cdd:cd21435    1 QEAFQESSVKELGRLEAQLASLRQELAALTLKQEAIQKELEQTKQKTISAVGEQL 55
HTH_SUN2 pfam18580
SUN2 helix-turn-helix domain; LINC complexes are formed by coupling of KASH (Klarsicht, ANC-1, ...
 547-605 1.52e-07

SUN2 helix-turn-helix domain; LINC complexes are formed by coupling of KASH (Klarsicht, ANC-1, and Syne/Nesprin Homology) and SUN (Sad1 and UNC-84) proteins from the inner and outer nuclear membranes (INM and ONM, respectively). the formation of LINC complexes by KASH and SUN proteins at the nuclear envelope (NE) establishes the physical linkage between the cytoskeleton and nuclear lamina, which is instrumental for the mechanical force transmission from the cytoplasm to the nuclear interior, and is essential for cellular processes such as nuclear positioning and migration, centrosome-nucleus anchorage, and chromosome dynamics. This entry represents an HTH domain found in SUN2 that forms a three-helix bundle to lock the SUN domain in an inactive conformation acting as an inhibitory component.


Pssm-ID: 436594 [Multi-domain]  Cd Length: 58  Bit Score: 48.87  E-value: 1.52e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 795441033  547 LHTMLRDLELQILRNVTHHISVTKRlPASEVVVSAVSEAGASGITEAQARAIVNNALKL 605
Cdd:pfam18580   1 LQAQLQDLEQRILAKLAEEQGKSAR-DAAASVGVALQQEGVTGVTEEQVHRIVNQALKR 58
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 366-539 1.02e-03

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 42.57  E-value: 1.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795441033  366 EQQVTSLSGQCHHHGENLRELTTLLQKLQARvdQMDNGAAGPSTSvrdavgqplKETD-FMAFHQEHEVRISHLEDILGK 444
Cdd:pfam07888  72 ERQRRELESRVAELKEELRQSREKHEELEEK--YKELSASSEELS---------EEKDaLLAQRAAHEARIRELEEDIKT 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795441033  445 LREKSEAIQKELEQTKQKTVSAVGEQLLPTVEH--LQLELDQLKSELsswRHMKTGCETVDALQERVDVQV---RETV-- 517
Cdd:pfam07888 141 LTQRVLERETELERMKERAKKAGAQRKEEEAERkqLQAKLQQTEEEL---RSLSKEFQELRNSLAQRDTQVlqlQDTItt 217

                         170       180
                  ....*....|....*....|....
gi 795441033  518 --KLLFSEDQQGGSLEQLLQRFSS 539
Cdd:pfam07888 218 ltQKLTTAHRKEAENEALLEELRS 241
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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