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Conserved domains on  [gi|1039794335|ref|XP_017169103|]
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ATP-dependent RNA helicase DHX30 isoform X1 [Mus musculus]

Protein Classification

ATP-dependent RNA helicase( domain architecture ID 13388279)

DEAD/DEAH box containing ATP-dependent RNA helicase catalyzes the unwinding of RNA, similar to DEAH box protein 34 (DHX34) that is required for nonsense-mediated decay (NMD) degradation of mRNA transcripts containing premature stop codons

CATH:  3.40.50.300
EC:  3.6.4.13
Gene Ontology:  GO:0005524|GO:0003724|GO:0003676|GO:0016887|GO:0003723
PubMed:  34680866|19747077|22922795|20206133|21779027|20225155

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HrpA super family cl34328
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
449-981 1.67e-135

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG1643:

Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 433.74  E-value: 1.67e-135
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  449 PIWQEAPQLPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLEryvtEGRGARCNVIITQPRRISAVSVAQRVSH 528
Cdd:COG1643      2 SLITYPPDLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLE----LGWGAGGRIGMLEPRRLAARAAAERMAE 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  529 ELGPSLRRNVGFQVRLESK--PPARggaLLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQ-RLN 605
Cdd:COG1643     78 ELGEPVGETVGYRVRFEDKvsAATR---IEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQpALR 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  606 PALRLVLMSATGDNERFSRYFGGCPVIKVPGFMYPVKEHYLEDilaklgkhqyphrhrhheSEDECALdLDLVTDLVLHI 685
Cdd:COG1643    155 PDLKLLVMSATLDAERFARLLGDAPVIESSGRTYPVEVRYRPL------------------PADERDL-EDAVADAVREA 215

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  686 dARGEPGGILCFLPGWQEIKGVQQRLQEALGMHeskYLILPVHSNIPMMDQKAIFQQPPLGVRKIVLATNIAETSITVND 765
Cdd:COG1643    216 -LAEEPGDILVFLPGEREIRRTAEALRGRLPPD---TEILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPG 291

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  766 IVHVVDSGLHKEERYDLKTKVSCLETVWVSRANVIQRRGRAGRCQSGFAYHLFPRSRLEKMVPFQVPEILRTPLENLVLQ 845
Cdd:COG1643    292 IRYVIDSGLARIPRYDPRSGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEEDFARRPAFTDPEILRADLASLILE 371

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  846 -AKIHMPEKTAVEFLskavDSPNIKAVDEAVILLQEIGVLDQREYLTTLGQRLAHISTDPRLAKAIVLAAIFRCLHPLLV 924
Cdd:COG1643    372 lAAWGLGDPEDLPFL----DPPPARAIADARALLQELGALDADGRLTPLGRALARLPLDPRLARMLLAAAELGCLREAAI 447

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039794335  925 VVSCLT-RDPfssslqnraevdkvkalLSHDSGSDHLAFVRAVAGWEEVL----------RWQDRTSR 981
Cdd:COG1643    448 LAALLSeRDP-----------------RRGAAGSDLLARLNLWRRLREQQreflsylrlrEWRDLARQ 498
OB_NTP_bind pfam07717
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ...
 1038-1125 5.34e-07

Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.


:

Pssm-ID: 400182 [Multi-domain]  Cd Length: 82  Bit Score: 48.40  E-value: 5.34e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335 1038 VKGVLMAGLYPNLiqvrqGKVTRQGKfkpnsvTYRTKSGN--ILLHKSTINREATRLRSRWLTYFMAVKSNgSVFVRDSS 1115
Cdd:pfam07717    1 LRAALAAGLYPNV-----ARRDPKGK------GYTTLSDNqrVFIHPSSVLFNEKTFPPEWVVYQELVETT-KVYIRTVT 68

                           90
                   ....*....|
gi 1039794335 1116 QVHPLAVLLL 1125
Cdd:pfam07717   69 AISPEWLLLF 78
 
Name Accession Description Interval E-value
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
449-981 1.67e-135

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 433.74  E-value: 1.67e-135
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  449 PIWQEAPQLPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLEryvtEGRGARCNVIITQPRRISAVSVAQRVSH 528
Cdd:COG1643      2 SLITYPPDLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLE----LGWGAGGRIGMLEPRRLAARAAAERMAE 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  529 ELGPSLRRNVGFQVRLESK--PPARggaLLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQ-RLN 605
Cdd:COG1643     78 ELGEPVGETVGYRVRFEDKvsAATR---IEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQpALR 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  606 PALRLVLMSATGDNERFSRYFGGCPVIKVPGFMYPVKEHYLEDilaklgkhqyphrhrhheSEDECALdLDLVTDLVLHI 685
Cdd:COG1643    155 PDLKLLVMSATLDAERFARLLGDAPVIESSGRTYPVEVRYRPL------------------PADERDL-EDAVADAVREA 215

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  686 dARGEPGGILCFLPGWQEIKGVQQRLQEALGMHeskYLILPVHSNIPMMDQKAIFQQPPLGVRKIVLATNIAETSITVND 765
Cdd:COG1643    216 -LAEEPGDILVFLPGEREIRRTAEALRGRLPPD---TEILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPG 291

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  766 IVHVVDSGLHKEERYDLKTKVSCLETVWVSRANVIQRRGRAGRCQSGFAYHLFPRSRLEKMVPFQVPEILRTPLENLVLQ 845
Cdd:COG1643    292 IRYVIDSGLARIPRYDPRSGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEEDFARRPAFTDPEILRADLASLILE 371

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  846 -AKIHMPEKTAVEFLskavDSPNIKAVDEAVILLQEIGVLDQREYLTTLGQRLAHISTDPRLAKAIVLAAIFRCLHPLLV 924
Cdd:COG1643    372 lAAWGLGDPEDLPFL----DPPPARAIADARALLQELGALDADGRLTPLGRALARLPLDPRLARMLLAAAELGCLREAAI 447

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039794335  925 VVSCLT-RDPfssslqnraevdkvkalLSHDSGSDHLAFVRAVAGWEEVL----------RWQDRTSR 981
Cdd:COG1643    448 LAALLSeRDP-----------------RRGAAGSDLLARLNLWRRLREQQreflsylrlrEWRDLARQ 498
DEXHc_DHX30 cd17976
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ...
 457-634 3.43e-121

DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350734 [Multi-domain]  Cd Length: 178  Bit Score: 371.43  E-value: 3.43e-121
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  457 LPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRR 536
Cdd:cd17976      1 LPVDSHKESILSAIEQNPVVVISGDTGCGKTTRIPQFILEDYVLRGRGARCNVVITQPRRISAVSVAQRVAHELGPNLRR 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  537 NVGFQVRLESKPPARGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSAT 616
Cdd:cd17976     81 NVGYQVRLESRPPPRGGALLFCTVGVLLKKLQSNPRLEGVSHVIVDEVHERDVNTDFLLILLKGVLQLNPELRVVLMSAT 160

                          170
                   ....*....|....*...
gi 1039794335  617 GDNERFSRYFGGCPVIKV 634
Cdd:cd17976    161 GDNQRLSRYFGGCPVVRV 178
PRK11131 PRK11131
ATP-dependent RNA helicase HrpA; Provisional
 431-963 2.71e-83

ATP-dependent RNA helicase HrpA; Provisional


Pssm-ID: 182986 [Multi-domain]  Cd Length: 1294  Bit Score: 297.74  E-value: 2.71e-83
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  431 AEEVRLSQSLLELWRRRGPIWQEAPQLPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLERyvteGRGARCNVI 510
Cdd:PRK11131    47 AKEIAQAAQRVLLREAARPEITYPENLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLEL----GRGVKGLIG 122

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  511 ITQPRRISAVSVAQRVSHELGPSLRRNVGFQVRLESKPPARGGALLFcTVGILLRKLQSNPSLEGVSHVIVDEVHERDVN 590
Cdd:PRK11131   123 HTQPRRLAARTVANRIAEELETELGGCVGYKVRFNDQVSDNTMVKLM-TDGILLAEIQQDRLLMQYDTIIIDEAHERSLN 201

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  591 TDFLLILLKGLQRLNPALRLVLMSATGDNERFSRYFGGCPVIKVPGFMYPVKEHYledilaklgkhqyphRHRHHESEDE 670
Cdd:PRK11131   202 IDFILGYLKELLPRRPDLKVIITSATIDPERFSRHFNNAPIIEVSGRTYPVEVRY---------------RPIVEEADDT 266

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  671 CALDLDLVTDLVLHIDARGePGGILCFLPGWQEIKGVQQRLQEALGMHESkylILPVHSNIPMMDQKAIFQqpPLGVRKI 750
Cdd:PRK11131   267 ERDQLQAIFDAVDELGREG-PGDILIFMSGEREIRDTADALNKLNLRHTE---ILPLYARLSNSEQNRVFQ--SHSGRRI 340

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  751 VLATNIAETSITVNDIVHVVDSGLHKEERYDLKTKVSCLETVWVSRANVIQRRGRAGRCQSGFAYHLFPRSRLEKMVPFQ 830
Cdd:PRK11131   341 VLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDDFLSRPEFT 420

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  831 VPEILRTPLENLVLQ-AKIHMPEKTAVEFlskaVDSPNIKAVDEAVILLQEIGVLDQRE-----YLTTLGQRLAHISTDP 904
Cdd:PRK11131   421 DPEILRTNLASVILQmTALGLGDIAAFPF----VEAPDKRNIQDGVRLLEELGAITTDEqasayKLTPLGRQLAQLPVDP 496

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  905 RLAKAIVLAAIFRCLHPLLVVVSCLT-RDPFSSSLQNRAEVDKvKALLSHDSGSDHLAFV 963
Cdd:PRK11131   497 RLARMVLEAQKHGCVREVMIITSALSiQDPRERPMDKQQASDE-KHRRFADKESDFLAFV 555
DEXDc smart00487
DEAD-like helicases superfamily;
461-640 1.42e-24

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 102.57  E-value: 1.42e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335   461 PHRDTILSAIEQHP-VVVISGDTGCGKTTRIPQLLLERYvteGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRRNVG 539
Cdd:smart00487   11 PYQKEAIEALLSGLrDVILAAPTGSGKTLAALLPALEAL---KRGKGGRVLVLVPTRELAEQWAEELKKLGPSLGLKVVG 87

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335   540 FQVRLESKPPAR-----GGALLFCTVGILLRKLQSNP-SLEGVSHVIVDEVHERDvNTDFLLILLKGLQRLNPALRLVLM 613
Cdd:smart00487   88 LYGGDSKREQLRklesgKTDILVTTPGRLLDLLENDKlSLSNVDLVILDEAHRLL-DGGFGDQLEKLLKLLPKNVQLLLL 166

                           170       180
                    ....*....|....*....|....*....
gi 1039794335   614 SAT--GDNERFSRYFGGCPVIKVPGFMYP 640
Cdd:smart00487  167 SATppEEIENLLELFLNDPVFIDVGFTPL 195
HA2 pfam04408
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ...
 874-962 3.17e-17

Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 461295 [Multi-domain]  Cd Length: 104  Bit Score: 78.43  E-value: 3.17e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  874 AVILLQEIGVLDQREYLTTLGQRLAHISTDPRLAKAIVLAAIFRCLHPLLVVVSCLT-RDPFSSSLQ------------- 939
Cdd:pfam04408    1 ALELLYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSvRDPFVQPNFldprsaakaarrr 80

                           90       100
                   ....*....|....*....|....
gi 1039794335  940 NRAEVDKVKALLSH-DSGSDHLAF 962
Cdd:pfam04408   81 RRAADEKARAKFARlDLEGDHLTL 104
OB_NTP_bind pfam07717
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ...
 1038-1125 5.34e-07

Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.


Pssm-ID: 400182 [Multi-domain]  Cd Length: 82  Bit Score: 48.40  E-value: 5.34e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335 1038 VKGVLMAGLYPNLiqvrqGKVTRQGKfkpnsvTYRTKSGN--ILLHKSTINREATRLRSRWLTYFMAVKSNgSVFVRDSS 1115
Cdd:pfam07717    1 LRAALAAGLYPNV-----ARRDPKGK------GYTTLSDNqrVFIHPSSVLFNEKTFPPEWVVYQELVETT-KVYIRTVT 68

                           90
                   ....*....|
gi 1039794335 1116 QVHPLAVLLL 1125
Cdd:pfam07717   69 AISPEWLLLF 78
 
Name Accession Description Interval E-value
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
449-981 1.67e-135

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 433.74  E-value: 1.67e-135
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  449 PIWQEAPQLPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLEryvtEGRGARCNVIITQPRRISAVSVAQRVSH 528
Cdd:COG1643      2 SLITYPPDLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLE----LGWGAGGRIGMLEPRRLAARAAAERMAE 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  529 ELGPSLRRNVGFQVRLESK--PPARggaLLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQ-RLN 605
Cdd:COG1643     78 ELGEPVGETVGYRVRFEDKvsAATR---IEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQpALR 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  606 PALRLVLMSATGDNERFSRYFGGCPVIKVPGFMYPVKEHYLEDilaklgkhqyphrhrhheSEDECALdLDLVTDLVLHI 685
Cdd:COG1643    155 PDLKLLVMSATLDAERFARLLGDAPVIESSGRTYPVEVRYRPL------------------PADERDL-EDAVADAVREA 215

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  686 dARGEPGGILCFLPGWQEIKGVQQRLQEALGMHeskYLILPVHSNIPMMDQKAIFQQPPLGVRKIVLATNIAETSITVND 765
Cdd:COG1643    216 -LAEEPGDILVFLPGEREIRRTAEALRGRLPPD---TEILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPG 291

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  766 IVHVVDSGLHKEERYDLKTKVSCLETVWVSRANVIQRRGRAGRCQSGFAYHLFPRSRLEKMVPFQVPEILRTPLENLVLQ 845
Cdd:COG1643    292 IRYVIDSGLARIPRYDPRSGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEEDFARRPAFTDPEILRADLASLILE 371

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  846 -AKIHMPEKTAVEFLskavDSPNIKAVDEAVILLQEIGVLDQREYLTTLGQRLAHISTDPRLAKAIVLAAIFRCLHPLLV 924
Cdd:COG1643    372 lAAWGLGDPEDLPFL----DPPPARAIADARALLQELGALDADGRLTPLGRALARLPLDPRLARMLLAAAELGCLREAAI 447

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039794335  925 VVSCLT-RDPfssslqnraevdkvkalLSHDSGSDHLAFVRAVAGWEEVL----------RWQDRTSR 981
Cdd:COG1643    448 LAALLSeRDP-----------------RRGAAGSDLLARLNLWRRLREQQreflsylrlrEWRDLARQ 498
DEXHc_DHX30 cd17976
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ...
 457-634 3.43e-121

DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350734 [Multi-domain]  Cd Length: 178  Bit Score: 371.43  E-value: 3.43e-121
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  457 LPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRR 536
Cdd:cd17976      1 LPVDSHKESILSAIEQNPVVVISGDTGCGKTTRIPQFILEDYVLRGRGARCNVVITQPRRISAVSVAQRVAHELGPNLRR 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  537 NVGFQVRLESKPPARGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSAT 616
Cdd:cd17976     81 NVGYQVRLESRPPPRGGALLFCTVGVLLKKLQSNPRLEGVSHVIVDEVHERDVNTDFLLILLKGVLQLNPELRVVLMSAT 160

                          170
                   ....*....|....*...
gi 1039794335  617 GDNERFSRYFGGCPVIKV 634
Cdd:cd17976    161 GDNQRLSRYFGGCPVVRV 178
PRK11131 PRK11131
ATP-dependent RNA helicase HrpA; Provisional
 431-963 2.71e-83

ATP-dependent RNA helicase HrpA; Provisional


Pssm-ID: 182986 [Multi-domain]  Cd Length: 1294  Bit Score: 297.74  E-value: 2.71e-83
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  431 AEEVRLSQSLLELWRRRGPIWQEAPQLPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLERyvteGRGARCNVI 510
Cdd:PRK11131    47 AKEIAQAAQRVLLREAARPEITYPENLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLEL----GRGVKGLIG 122

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  511 ITQPRRISAVSVAQRVSHELGPSLRRNVGFQVRLESKPPARGGALLFcTVGILLRKLQSNPSLEGVSHVIVDEVHERDVN 590
Cdd:PRK11131   123 HTQPRRLAARTVANRIAEELETELGGCVGYKVRFNDQVSDNTMVKLM-TDGILLAEIQQDRLLMQYDTIIIDEAHERSLN 201

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  591 TDFLLILLKGLQRLNPALRLVLMSATGDNERFSRYFGGCPVIKVPGFMYPVKEHYledilaklgkhqyphRHRHHESEDE 670
Cdd:PRK11131   202 IDFILGYLKELLPRRPDLKVIITSATIDPERFSRHFNNAPIIEVSGRTYPVEVRY---------------RPIVEEADDT 266

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  671 CALDLDLVTDLVLHIDARGePGGILCFLPGWQEIKGVQQRLQEALGMHESkylILPVHSNIPMMDQKAIFQqpPLGVRKI 750
Cdd:PRK11131   267 ERDQLQAIFDAVDELGREG-PGDILIFMSGEREIRDTADALNKLNLRHTE---ILPLYARLSNSEQNRVFQ--SHSGRRI 340

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  751 VLATNIAETSITVNDIVHVVDSGLHKEERYDLKTKVSCLETVWVSRANVIQRRGRAGRCQSGFAYHLFPRSRLEKMVPFQ 830
Cdd:PRK11131   341 VLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDDFLSRPEFT 420

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  831 VPEILRTPLENLVLQ-AKIHMPEKTAVEFlskaVDSPNIKAVDEAVILLQEIGVLDQRE-----YLTTLGQRLAHISTDP 904
Cdd:PRK11131   421 DPEILRTNLASVILQmTALGLGDIAAFPF----VEAPDKRNIQDGVRLLEELGAITTDEqasayKLTPLGRQLAQLPVDP 496

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  905 RLAKAIVLAAIFRCLHPLLVVVSCLT-RDPFSSSLQNRAEVDKvKALLSHDSGSDHLAFV 963
Cdd:PRK11131   497 RLARMVLEAQKHGCVREVMIITSALSiQDPRERPMDKQQASDE-KHRRFADKESDFLAFV 555
DEXHc_RHA-like cd17917
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ...
 473-634 2.45e-81

DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438707 [Multi-domain]  Cd Length: 159  Bit Score: 262.78  E-value: 2.45e-81
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  473 HPVVVISGDTGCGKTTRIPQLLLERYVTegRGARCNVIITQPRRISAVSVAQRVSHELGPSLRRNVGFQVRLESKPPaRG 552
Cdd:cd17917      1 NQVVVIVGETGSGKTTQVPQFLLEDGLA--KGGKGRIVCTQPRRIAAISVAERVAEERGEKLGEEVGYQIRFESKTS-SK 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  553 GALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSATGDNERFSRYFGGCPVI 632
Cdd:cd17917     78 TRIKFCTDGILLRELLSDPLLSGYSHVILDEAHERSLDTDFLLGLLKDLLRKRPDLKVILMSATLDAEKFSSYFGGAPVI 157


                   ..
gi 1039794335  633 KV 634
Cdd:cd17917    158 HI 159
PRK11664 PRK11664
ATP-dependent RNA helicase HrpB; Provisional
 455-914 5.71e-81

ATP-dependent RNA helicase HrpB; Provisional


Pssm-ID: 236950 [Multi-domain]  Cd Length: 812  Bit Score: 283.35  E-value: 5.71e-81
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  455 PQLPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRgarcnVIITQPRRISAVSVAQRVSHELGPSL 534
Cdd:PRK11664     2 SSLPVAAVLPELLTALKTAPQVLLKAPTGAGKSTWLPLQLLQHGGINGK-----IIMLEPRRLAARNVAQRLAEQLGEKP 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  535 RRNVGFQVRLESK--PPARggaLLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQR-LNPALRLV 611
Cdd:PRK11664    77 GETVGYRMRAESKvgPNTR---LEVVTEGILTRMIQRDPELSGVGLVILDEFHERSLQADLALALLLDVQQgLRDDLKLL 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  612 LMSATGDNERFSRYFGGCPVIKVPGFMYPVKEHYledilAKLGKHQYphrhrhheSEDECAldlDLVTDLVlhidaRGEP 691
Cdd:PRK11664   154 IMSATLDNDRLQQLLPDAPVIVSEGRSFPVERRY-----QPLPAHQR--------FDEAVA---RATAELL-----RQES 212

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  692 GGILCFLPGWQEIKGVQQRLQEALGmheSKYLILPVHSNIPMMDQ-KAIfQQPPLGVRKIVLATNIAETSITVNDIVHVV 770
Cdd:PRK11664   213 GSLLLFLPGVGEIQRVQEQLASRVA---SDVLLCPLYGALSLAEQqKAI-LPAPAGRRKVVLATNIAETSLTIEGIRLVV 288

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  771 DSGLHKEERYDLKTKVSCLETVWVSRANVIQRRGRAGRCQSGFAYHLFPRSRLEKMVPFQVPEILRTPLENLV---LQAK 847
Cdd:PRK11664   289 DSGLERVARFDPKTGLTRLVTQRISQASMTQRAGRAGRLEPGICLHLYSKEQAERAAAQSEPEILHSDLSGLLlelLQWG 368

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039794335  848 IHMPEKTaveflsKAVDSPNIKAVDEAVILLQEIGVLDQREYLTTLGQRLAHISTDPRLAkAIVLAA 914
Cdd:PRK11664   369 CHDPAQL------SWLDQPPAAALAAAKRLLQQLGALDGQGRLTARGRKMAALGNDPRLA-AMLVAA 428
SF2_C_RHA cd18791
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ...
 639-818 2.58e-78

C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350178 [Multi-domain]  Cd Length: 171  Bit Score: 254.77  E-value: 2.58e-78
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  639 YPVKEHYLEDILAKLGKHqyphrhrhheSEDECALDLDLVTDLVLHIDARGEPGGILCFLPGWQEIKGVQQRL-QEALGM 717
Cdd:cd18791      1 FPVEVYYLEDILELLGIS----------SEKEDPDYVDAAVRLILQIHRTEEPGDILVFLPGQEEIERLCELLrEELLSP 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  718 HESKYLILPVHSNIPMMDQKAIFQQPPLGVRKIVLATNIAETSITVNDIVHVVDSGLHKEERYDLKTKVSCLETVWVSRA 797
Cdd:cd18791     71 DLGKLLVLPLHSSLPPEEQQRVFEPPPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKA 150

                          170       180
                   ....*....|....*....|.
gi 1039794335  798 NVIQRRGRAGRCQSGFAYHLF 818
Cdd:cd18791    151 SAEQRAGRAGRTRPGKCYRLY 171
DEXHc_DHX9 cd17972
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ...
 427-634 1.75e-72

DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350730 [Multi-domain]  Cd Length: 234  Bit Score: 241.28  E-value: 1.75e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  427 PLSEAEEVRLSQSLL-ELWRRRG------PIWQEAPQLPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLERYV 499
Cdd:cd17972     22 PLAFATPEQISMDLKnELMYQREqdhnlqQILQERELLPVKKFREEILEAISNNPVVIIRGATGCGKTTQVPQYILDDFI 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  500 TEGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRRNVGFQVRLESKPPARGGALLFCTVGILLRKLQSnpSLEGVSHV 579
Cdd:cd17972    102 QNDRAAECNIVVTQPRRISAVSVAERVAFERGEEVGKSCGYSVRFESVLPRPHASILFCTVGVLLRKLEA--GIRGISHV 179

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1039794335  580 IVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSATGDNERFSRYFGGCPVIKV 634
Cdd:cd17972    180 IVDEIHERDINTDFLLVVLRDVVQAYPDLRVILMSATIDTSMFCEYFFNCPVIEV 234
DEXHc_DHX36 cd17981
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ...
 457-634 9.12e-63

DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350739 [Multi-domain]  Cd Length: 180  Bit Score: 211.24  E-value: 9.12e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  457 LPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARCNVIITQPRRISAVSVAQRVSHELGPS--L 534
Cdd:cd17981      1 LPSYGMKQEIINMIDNNQVTVISGETGCGKTTQVTQFILDDAIERGKGSSCRIVCTQPRRISAISVAERVAAERAEScgL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  535 RRNVGFQVRLESKPPARGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMS 614
Cdd:cd17981     81 GNSTGYQIRLESRKPRKQGSILYCTTGIVLQWLQSDPHLSNVSHLVLDEIHERNLQSDVLMGIVKDLLPFRSDLKVILMS 160

                          170       180
                   ....*....|....*....|
gi 1039794335  615 ATGDNERFSRYFGGCPVIKV 634
Cdd:cd17981    161 ATLNAEKFSDYFNNCPMIHI 180
DEXHc_DHX57 cd17985
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ...
 449-634 5.05e-61

DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350743 [Multi-domain]  Cd Length: 177  Bit Score: 206.23  E-value: 5.05e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  449 PIWQEapqlpvdphRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARCNVIITQPRRISAVSVAQRVSH 528
Cdd:cd17985      2 PAWQE---------RETILELLEKHQVLVISGMTGCGKTTQIPQFILDNSLQGPPLPVANIICTQPRRISAISVAERVAQ 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  529 ELGPSLRRNVGFQVRLESKPPArGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPAL 608
Cdd:cd17985     73 ERAERVGQSVGYQIRLESVKSS-ATRLLYCTTGVLLRRLEGDPTLQGVTHVIVDEVHERTEESDFLLLVLKDLMVQRPDL 151

                          170       180
                   ....*....|....*....|....*.
gi 1039794335  609 RLVLMSATGDNERFSRYFGGCPVIKV 634
Cdd:cd17985    152 KVILMSATLNAELFSDYFNSCPVIHI 177
DEXHc_DHX29 cd17975
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ...
 457-634 1.33e-59

DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350733 [Multi-domain]  Cd Length: 183  Bit Score: 202.45  E-value: 1.33e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  457 LPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLERYV-TEGRGARCNVIITQPRRISAVSVAQRVSHELG---- 531
Cdd:cd17975      1 LPVFKHRESILETLKRHRVVVVAGETGSGKSTQVPQFLLEDLLlNGGTAQKCNIVCTQPRRISAMSLATRVCEELGcesg 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  532 PSLRRNV-GFQVRLESKPpARGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRL 610
Cdd:cd17975     81 PGGKNSLcGYQIRMESRT-GEATRLLYCTTGVLLRKLQEDGLLSSISHIIVDEVHERSVQSDFLLIILKEILHKRSDLHL 159

                          170       180
                   ....*....|....*....|....
gi 1039794335  611 VLMSATGDNERFSRYFGGCPVIKV 634
Cdd:cd17975    160 ILMSATVDCEKFSSYFTHCPILRI 183
DEXHc_YTHDC2 cd17987
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ...
 457-634 6.89e-53

DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350745 [Multi-domain]  Cd Length: 176  Bit Score: 183.11  E-value: 6.89e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  457 LPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLERyvTEGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRR 536
Cdd:cd17987      1 LPVFEKQEQIVRIIKENKVVLIVGETGSGKTTQIPQFLLDD--CYANGIPCRIFCTQPRRLAAIAVAERVAAERGEKIGQ 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  537 NVGFQVRLESKPPARGgALLFCTVGILLRKLQSNPS-LEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSA 615
Cdd:cd17987     79 TVGYQIRLESRVSPKT-LLTFCTNGVLLRTLMAGDSaLSTVTHVIVDEVHERDRFSDFLLTKLRDILQKHPNLKLILSSA 157

                          170
                   ....*....|....*....
gi 1039794335  616 TGDNERFSRYFGGCPVIKV 634
Cdd:cd17987    158 ALDVNLFIRYFGSCPVIYI 176
DEXHc_TDRD9 cd17988
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ...
 457-641 1.58e-51

DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350746 [Multi-domain]  Cd Length: 180  Bit Score: 179.23  E-value: 1.58e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  457 LPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTegRGARCNVIITQPRRISAVSVAQRVSHELGPSLRR 536
Cdd:cd17988      1 LPIYAKREEILSLIEANSVVIIKGATGCGKTTQLPQFILDHYYK--RGKYCNIVVTQPRRIAAISIARRVSQEREWTLGS 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  537 NVGFQVRLEsKPPARGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPA-LRLVLMSA 615
Cdd:cd17988     79 LVGYQVGLE-RPASEETRLIYCTTGVLLQKLINNKTLTEYTHIILDEVHERDQELDFLLLVVRRLLRTNSRhVKIILMSA 157

                          170       180
                   ....*....|....*....|....*.
gi 1039794335  616 TGDNERFSRYFGgcpVIKVPGFMYPV 641
Cdd:cd17988    158 TISCKEFADYFT---TPNNPAYVFEV 180
DEXHc_DHX33 cd17978
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ...
 457-632 5.25e-50

DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438710 [Multi-domain]  Cd Length: 178  Bit Score: 174.85  E-value: 5.25e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  457 LPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRgarcnVI-ITQPRRISAVSVAQRVSHELGPSLR 535
Cdd:cd17978      1 LPIYSARKRLLEELRKHDTVIIIGETGSGKTTQIPQYLYEAGFARGG-----MIgITQPRRVAAVSVAKRVAEEMGVELG 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  536 RNVGFQVRLESKpPARGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLN-----PALRL 610
Cdd:cd17978     76 QLVGYSVRFDDV-TSEETRIKYMTDGMLLREAIGDPLLSKYSVIILDEAHERTVHTDVLFGLVKSAQRRRkeqklSPLKV 154

                          170       180
                   ....*....|....*....|..
gi 1039794335  611 VLMSATGDNERFSRYFGGCPVI 632
Cdd:cd17978    155 IIMSATLDADLFSEYFNGAPVL 176
DEXHc_DHX34 cd17979
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ...
 457-634 2.60e-49

DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350737 [Multi-domain]  Cd Length: 170  Bit Score: 172.63  E-value: 2.60e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  457 LPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTegrgarcNVIITQPRRISAVSVAQRVSHELGPSLRR 536
Cdd:cd17979      1 LPIAQYREKIIELLKTHQVVIVAGDTGCGKSTQVPQYLLAAGFR-------HIACTQPRRIACISLAKRVAFESLNQYGS 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  537 NVGFQVRLESKPPARGgALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSAT 616
Cdd:cd17979     74 KVAYQIRFERTRTLAT-KLLFLTEGLLLRQIQRDASLPQYNVLILDEVHERHLHGDFLLGVLRCLLRLRPDLKLILMSAT 152

                          170
                   ....*....|....*...
gi 1039794335  617 GDNERFSRYFGGCPVIKV 634
Cdd:cd17979    153 INIELFSGYFEGAPVVQV 170
DEXHc_DHX15 cd17973
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ...
 450-634 5.04e-46

DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438709 [Multi-domain]  Cd Length: 187  Bit Score: 163.74  E-value: 5.04e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  450 IWQEAPQLPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARcnVIITQPRRISAVSVAQRVSHE 529
Cdd:cd17973      6 ILEKRRELPVWEQKEDFLKLLKNNQILVLVGETGSGKTTQIPQFVLDDELPHQPKKL--VACTQPRRVAAMSVAQRVAEE 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  530 LGPSLRRNVGFQVRLESKPPARGgALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALR 609
Cdd:cd17973     84 MDVKLGEEVGYSIRFEDCSSAKT-ILKYMTDGMLLREAMSDPLLSRYSVIILDEAHERTLATDILMGLLKEVVRRRPDLK 162

                          170       180
                   ....*....|....*....|....*
gi 1039794335  610 LVLMSATGDNERFSRYFGGCPVIKV 634
Cdd:cd17973    163 LIVMSATLDAGKFQKYFDNAPLLKV 187
DEXHc_DHX16 cd17974
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ...
 457-634 7.69e-46

DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350732 [Multi-domain]  Cd Length: 174  Bit Score: 162.67  E-value: 7.69e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  457 LPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARCnviITQPRRISAVSVAQRVSHELGPSLRR 536
Cdd:cd17974      1 LPVYPYRDDLLAAVKEHQVLIIVGETGSGKTTQIPQYLHEAGYTKGGGKIG---CTQPRRVAAMSVAARVAEEMGVKLGN 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  537 NVGFQVRLESKPPARGgALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSAT 616
Cdd:cd17974     78 EVGYSIRFEDCTSEKT-VLKYMTDGMLLREFLTEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPDLKLLISSAT 156

                          170
                   ....*....|....*...
gi 1039794335  617 GDNERFSRYFGGCPVIKV 634
Cdd:cd17974    157 MDAEKFSAFFDDAPIFRI 174
DEXHc_HrpB cd17990
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ...
 457-634 2.13e-45

DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438711 [Multi-domain]  Cd Length: 174  Bit Score: 161.35  E-value: 2.13e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  457 LPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRgarcNVIITQPRRISAVSVAQRVSHELGPSLRR 536
Cdd:cd17990      1 LPIAAVLPALRAALDAGGQVVLEAPPGAGKTTRVPLALLAELWIAGG----KIIVLEPRRVAARAAARRLATLLGEAPGE 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  537 NVGFQVRLESKPpARGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQR-LNPALRLVLMSA 615
Cdd:cd17990     77 TVGYRVRGESRV-GRRTRVEVVTEGVLLRRLQRDPELSGVGAVILDEFHERSLDADLALALLLEVQQlLRDDLRLLAMSA 155

                          170
                   ....*....|....*....
gi 1039794335  616 TGDNERFSRYFGGCPVIKV 634
Cdd:cd17990    156 TLDGDGLAALLPEAPVVES 174
DEXHc_HrpA cd17989
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ...
 457-634 2.71e-45

DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350747 [Multi-domain]  Cd Length: 173  Bit Score: 161.08  E-value: 2.71e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  457 LPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLERyvteGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRR 536
Cdd:cd17989      1 LPVSQKRDEIAKAIAENQVVIIAGETGSGKTTQLPKICLEL----GRGIRGLIGHTQPRRLAARSVAERIAEELKTELGG 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  537 NVGFQVRLESKPPARGGALLFcTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSAT 616
Cdd:cd17989     77 AVGYKVRFTDQTSDETCVKLM-TDGILLAETQTDRYLRAYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKVIITSAT 155

                          170
                   ....*....|....*...
gi 1039794335  617 GDNERFSRYFGGCPVIKV 634
Cdd:cd17989    156 IDAERFSRHFNNAPIIEV 173
DEXHc_DHX35 cd17980
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ...
 457-626 4.05e-44

DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350738 [Multi-domain]  Cd Length: 185  Bit Score: 158.40  E-value: 4.05e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  457 LPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLER-YVTEGRgarcNVIITQPRRISAVSVAQRVSHELGPSLR 535
Cdd:cd17980      1 LPVFKLRNHILYLVENYQTIVIVGETGCGKSTQIPQYLAEAgWTAGGR----VVGCTQPRRVAAVTVAGRVAEEMGAVLG 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  536 RNVGFQVRLESKPPARGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSA 615
Cdd:cd17980     77 HEVGYCIRFDDCTDPQATRIKFLTDGMLVREMMLDPLLTKYSVIMLDEAHERTLYTDILIGLLKKIQKKRGDLRLIVASA 156

                          170
                   ....*....|.
gi 1039794335  616 TGDNERFSRYF 626
Cdd:cd17980    157 TLDAEKFRDFF 167
DEXHc_DHX37 cd17982
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ...
 457-634 1.51e-43

DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350740 [Multi-domain]  Cd Length: 191  Bit Score: 156.75  E-value: 1.51e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  457 LPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARCNVI-ITQPRRISAVSVAQRVSHELGpSLR 535
Cdd:cd17982      1 LPILAEEQEIMEAINENPVVIICGETGSGKTTQVPQFLYEAGFGSPESDNPGMIgITQPRRVAAVSMAKRVAEELN-VFG 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  536 RNVGFQVRLESKpPARGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILL-----------KGLQRL 604
Cdd:cd17982     80 KEVSYQIRYDST-VSENTKIKFMTDGVLLKEIQTDFLLRKYSVIIIDEAHERSVNTDILIGMLsrivplraklyLQDQTV 158

                          170       180       190
                   ....*....|....*....|....*....|....
gi 1039794335  605 NPaLRLVLMSATGDNERFS---RYFGGCP-VIKV 634
Cdd:cd17982    159 KP-LKLVIMSATLRVEDFTenkLLFPRPPpVIKV 191
DEXHc_DHX8 cd17971
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ...
 457-635 4.15e-42

DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350729 [Multi-domain]  Cd Length: 179  Bit Score: 152.25  E-value: 4.15e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  457 LPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLEryvtEGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRR 536
Cdd:cd17971      6 LPIYKLKEQLIQAVHDNQILVVIGETGSGKTTQITQYLAE----AGYTSRGKIGCTQPRRVAAMSVAKRVAEEFGCCLGQ 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  537 NVGFQVRLESKPpARGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSAT 616
Cdd:cd17971     82 EVGYTIRFEDCT-SPETVIKYMTDGMLLRECLIDPDLSQYSVIMLDEAHERTIHTDVLFGLLKKTVQKRPDLKLIVTSAT 160

                          170
                   ....*....|....*....
gi 1039794335  617 GDNERFSRYFGGCPVIKVP 635
Cdd:cd17971    161 LDAVKFSQYFYEAPIFTIP 179
DEXHc_DHX38 cd17983
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ...
 457-634 1.28e-38

DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350741 [Multi-domain]  Cd Length: 173  Bit Score: 141.83  E-value: 1.28e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  457 LPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLEryvtEGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRR 536
Cdd:cd17983      1 LPIFAVRQELLNVIRDNNVVIVVGETGSGKTTQLTQYLHE----DGYTDYGMIGCTQPRRVAAMSVAKRVSEEMGVELGE 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  537 NVGFQVRLESKPPARGgALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSAT 616
Cdd:cd17983     77 EVGYAIRFEDCTSENT-VIKYMTDGILLRESLRDPDLDKYSAIIMDEAHERSLNTDVLFGLLREVVARRRDLKLIVTSAT 155

                          170
                   ....*....|....*...
gi 1039794335  617 GDNERFSRYFGGCPVIKV 634
Cdd:cd17983    156 MDADKFADFFGNVPIFTI 173
DEXHc_DHX40 cd17984
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ...
 457-634 2.63e-38

DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350742 [Multi-domain]  Cd Length: 178  Bit Score: 141.15  E-value: 2.63e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  457 LPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLEryvtEGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRR 536
Cdd:cd17984      1 LPIQKQRKKLVQAVRDNSFLIVTGNTGSGKTTQLPKYLYE----AGFSQHGMIGVTQPRRVAAISVAQRVAEEMKCTLGS 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  537 NVGFQVRLESKPPARgGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPA-----LRLV 611
Cdd:cd17984     77 KVGYQVRFDDCSSKE-TAIKYMTDGCLLRHILADPNLTKYSVIILDEAHERSLTTDILFGLLKKLFQEKSPnrkehLKVV 155

                          170       180
                   ....*....|....*....|...
gi 1039794335  612 LMSATGDNERFSRYFGGCPVIKV 634
Cdd:cd17984    156 VMSATLELAKLSAFFGNCPVFDI 178
DEXHc_DHX32 cd17977
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ...
 457-634 2.32e-27

DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350735 [Multi-domain]  Cd Length: 176  Bit Score: 109.92  E-value: 2.32e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  457 LPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLErYVTEGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRR 536
Cdd:cd17977      1 LPVWEAKYEFMESLAHNQIVIVSGDAKTGKSSQIPQWCAE-YCLSAHYQHGVVVCTQVHKQTAVWLALRVADEMDVNIGH 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  537 NVGFQVRLESkPPARGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSAT 616
Cdd:cd17977     80 EVGYVIPFEN-CCTNETILRYCTDDMLLREMMSDPLLESYGVIILDDAHERTVSTDVLLGLLKDVLLSRPELKLVIITCP 158

                          170
                   ....*....|....*...
gi 1039794335  617 GDNERFSRYFGGCPVIKV 634
Cdd:cd17977    159 HLSSKLLSYYGNVPLIEV 176
DEXDc smart00487
DEAD-like helicases superfamily;
461-640 1.42e-24

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 102.57  E-value: 1.42e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335   461 PHRDTILSAIEQHP-VVVISGDTGCGKTTRIPQLLLERYvteGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRRNVG 539
Cdd:smart00487   11 PYQKEAIEALLSGLrDVILAAPTGSGKTLAALLPALEAL---KRGKGGRVLVLVPTRELAEQWAEELKKLGPSLGLKVVG 87

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335   540 FQVRLESKPPAR-----GGALLFCTVGILLRKLQSNP-SLEGVSHVIVDEVHERDvNTDFLLILLKGLQRLNPALRLVLM 613
Cdd:smart00487   88 LYGGDSKREQLRklesgKTDILVTTPGRLLDLLENDKlSLSNVDLVILDEAHRLL-DGGFGDQLEKLLKLLPKNVQLLLL 166

                           170       180
                    ....*....|....*....|....*....
gi 1039794335   614 SAT--GDNERFSRYFGGCPVIKVPGFMYP 640
Cdd:smart00487  167 SATppEEIENLLELFLNDPVFIDVGFTPL 195
DEXQc_DQX1 cd17986
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ...
 457-634 2.10e-21

DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350744 [Multi-domain]  Cd Length: 177  Bit Score: 92.65  E-value: 2.10e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  457 LPVDPHRDTILSAIEQHP-VVVISGDTGCGKTTRIPQLLLErYVTEGRGARCNVIITQPRRISAVSVAQRVSHELGPSLR 535
Cdd:cd17986      1 LPIWAAKFTFLEQLESPSgIVLVSGEPGSGKSTQVPQWCAE-FALSRGFQKGQVTVTQPHPLAARSLALRVADEMDLNLG 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  536 RNVGFQVRLE--SKPPArggALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLM 613
Cdd:cd17986     80 HEVGYSIPQEdcTGPNT---ILRFCWDRLLLQEMTSTPLLGAWGVVVLDEAQERSVASDSLLGLLKDVRLQRPELRVVVV 156

                          170       180
                   ....*....|....*....|.
gi 1039794335  614 SATGDNERFSRYFGGCPVIKV 634
Cdd:cd17986    157 TSPALEPKLRAFWGNPPVVHV 177
PHA02653 PHA02653
RNA helicase NPH-II; Provisional
 466-812 4.66e-18

RNA helicase NPH-II; Provisional


Pssm-ID: 177443 [Multi-domain]  Cd Length: 675  Bit Score: 89.65  E-value: 4.66e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  466 ILSAIEQHPVVVISGDTGCGKTTRIPQLLLE-RYV---TEGRGARCNVIITQPRRISAVSVAQRVSHelGPSLRRNVGFQ 541
Cdd:PHA02653   172 IFEAWISRKPVVLTGGTGVGKTSQVPKLLLWfNYLfggFDNLDKIDPNFIERPIVLSLPRVALVRLH--SITLLKSLGFD 249

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  542 --------VRLESKPPA------RGGALLFCTvgillRKLQSNpSLEGVSHVIVDEVHERDVNTDFLL-ILLKGLQRLNp 606
Cdd:PHA02653   250 eidgspisLKYGSIPDElintnpKPYGLVFST-----HKLTLN-KLFDYGTVIIDEVHEHDQIGDIIIaVARKHIDKIR- 322

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  607 alRLVLMSAT--GDNERFSRYFGGCPVIKVPGF-MYPVKEHYLEDilaklgKHQYPHRHRHHESEDecaldldlvtDLVL 683
Cdd:PHA02653   323 --SLFLMTATleDDRDRIKEFFPNPAFVHIPGGtLFPISEVYVKN------KYNPKNKRAYIEEEK----------KNIV 384

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  684 HI--DARGEPG--GILcFLPGWQEIKGVQQRLQEALgmheSKYLILPVHSNIPMMDQ--KAIFQQPPLgvrKIVLATNIA 757
Cdd:PHA02653   385 TAlkKYTPPKGssGIV-FVASVSQCEEYKKYLEKRL----PIYDFYIIHGKVPNIDEilEKVYSSKNP---SIIISTPYL 456

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1039794335  758 ETSITVNDIVHVVDSG-LHKEERYDLKtkvscleTVWVSRANVIQRRGRAGRCQSG 812
Cdd:PHA02653   457 ESSVTIRNATHVYDTGrVYVPEPFGGK-------EMFISKSMRTQRKGRVGRVSPG 505
HA2 pfam04408
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ...
 874-962 3.17e-17

Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 461295 [Multi-domain]  Cd Length: 104  Bit Score: 78.43  E-value: 3.17e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  874 AVILLQEIGVLDQREYLTTLGQRLAHISTDPRLAKAIVLAAIFRCLHPLLVVVSCLT-RDPFSSSLQ------------- 939
Cdd:pfam04408    1 ALELLYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSvRDPFVQPNFldprsaakaarrr 80

                           90       100
                   ....*....|....*....|....
gi 1039794335  940 NRAEVDKVKALLSH-DSGSDHLAF 962
Cdd:pfam04408   81 RRAADEKARAKFARlDLEGDHLTL 104
HA2 smart00847
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ...
 880-963 5.59e-17

Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 214852 [Multi-domain]  Cd Length: 82  Bit Score: 76.92  E-value: 5.59e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335   880 EIGVLDQREYLTTLGQRLAHISTDPRLAKAIVLAAIFRCLHPLLVVVSCLTRDPFSSSlQNRAEVDKVKALLSHDsGSDH 959
Cdd:smart00847    1 ELGALDDDGRLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPRPK-EKREDADAARRRFADP-ESDH 78


                    ....
gi 1039794335   960 LAFV 963
Cdd:smart00847   79 LTLL 82
SF2-N cd00046
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ...
 473-616 1.30e-16

N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.


Pssm-ID: 350668 [Multi-domain]  Cd Length: 146  Bit Score: 77.83  E-value: 1.30e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  473 HPVVVISGDTGCGKTTRIPQLLLERYVTegrgARCNVIITQPRRISAVSVAQRVSHELGPSLRrnVGFQVRLESKPPARG 552
Cdd:cd00046      1 GENVLITAPTGSGKTLAALLAALLLLLK----KGKKVLVLVPTKALALQTAERLRELFGPGIR--VAVLVGGSSAEEREK 74

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039794335  553 GA-----LLFCTVGILLRKLQSN--PSLEGVSHVIVDEVHERDVNTDFLLIL-LKGLQRLNPALRLVLMSAT 616
Cdd:cd00046     75 NKlgdadIIIATPDMLLNLLLREdrLFLKDLKLIIVDEAHALLIDSRGALILdLAVRKAGLKNAQVILLSAT 146
HELICc smart00490
helicase superfamily c-terminal domain;
709-808 8.02e-13

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 64.93  E-value: 8.02e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335   709 QRLQEALGMHesKYLILPVHSNIPMMDQKAIFQQPPLGVRKIVLATNIAETSITVNDIVHVVDSGLhkeerydlktkvsc 788
Cdd:smart00490    1 EELAELLKEL--GIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDL-------------- 64

                            90       100
                    ....*....|....*....|
gi 1039794335   789 letvWVSRANVIQRRGRAGR 808
Cdd:smart00490   65 ----PWSPASYIQRIGRAGR 80
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
 476-616 3.62e-11

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 63.03  E-value: 3.62e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  476 VVISGDTGCGKTT--RIPqlLLERYVTEGRGARcnVIITQPRRISA---VSVAQRVSHELGPSLRRNVGFQVRLESKPPA 550
Cdd:pfam00270   17 VLVQAPTGSGKTLafLLP--ALEALDKLDNGPQ--ALVLAPTRELAeqiYEELKKLGKGLGLKVASLLGGDSRKEQLEKL 92

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039794335  551 RGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNtDFLLILLKGLQRLNPALRLVLMSAT 616
Cdd:pfam00270   93 KGPDILVGTPGRLLDLLQERKLLKNLKLLVLDEAHRLLDM-GFGPDLEEILRRLPKKRQILLLSAT 157
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 680-808 1.48e-10

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 59.53  E-value: 1.48e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  680 DLVLHIDARGEPGGILCFLPGWQEIKGvqQRLQEALGmheskYLILPVHSNIPMMDQKAIFQQPPLGVRKIVLATNIAET 759
Cdd:pfam00271    4 EALLELLKKERGGKVLIFSQTKKTLEA--ELLLEKEG-----IKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAER 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1039794335  760 SITVNDIVHVVDSGLHKeerydlktkvscletvwvSRANVIQRRGRAGR 808
Cdd:pfam00271   77 GLDLPDVDLVINYDLPW------------------NPASYIQRIGRAGR 107
OB_NTP_bind pfam07717
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ...
 1038-1125 5.34e-07

Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.


Pssm-ID: 400182 [Multi-domain]  Cd Length: 82  Bit Score: 48.40  E-value: 5.34e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335 1038 VKGVLMAGLYPNLiqvrqGKVTRQGKfkpnsvTYRTKSGN--ILLHKSTINREATRLRSRWLTYFMAVKSNgSVFVRDSS 1115
Cdd:pfam07717    1 LRAALAAGLYPNV-----ARRDPKGK------GYTTLSDNqrVFIHPSSVLFNEKTFPPEWVVYQELVETT-KVYIRTVT 68

                           90
                   ....*....|
gi 1039794335 1116 QVHPLAVLLL 1125
Cdd:pfam07717   69 AISPEWLLLF 78
DEXHc_Ski2 cd17921
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ...
 458-633 2.50e-05

DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350679 [Multi-domain]  Cd Length: 181  Bit Score: 46.10  E-value: 2.50e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  458 PVDPH-RDTILSAIEQHPVVVISGDTGCGKTTrIPQLLLERYVTEGRGarcNVIITQPRRisAVS--VAQRVSHELGPSl 534
Cdd:cd17921      1 LLNPIqREALRALYLSGDSVLVSAPTSSGKTL-IAELAILRALATSGG---KAVYIAPTR--ALVnqKEADLRERFGPL- 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  535 rrnvGFQVRL------ESKPPARGGALLFCT---VGILLRKLqSNPSLEGVSHVIVDEVH-----ERDVntdFLLILLKG 600
Cdd:cd17921     74 ----GKNVGLltgdpsVNKLLLAEADILVATpekLDLLLRNG-GERLIQDVRLVVVDEAHligdgERGV---VLELLLSR 145

                          170       180       190
                   ....*....|....*....|....*....|....
gi 1039794335  601 LQRLNPALRLVLMSATGDN-ERFSRYFGGCPVIK 633
Cdd:cd17921    146 LLRINKNARFVGLSATLPNaEDLAEWLGVEDLIR 179
SF2_C cd18785
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ...
 749-819 2.85e-03

C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350172 [Multi-domain]  Cd Length: 77  Bit Score: 37.68  E-value: 2.85e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039794335  749 KIVLATNIAETSITVNDIVHVVdsglhkeerydlktkvscLETVWVSRANVIQRRGRAGR-CQSGFAYHLFP 819
Cdd:cd18785     24 EILVATNVLGEGIDVPSLDTVI------------------FFDPPSSAASYIQRVGRAGRgGKDEGEVILFV 77
SSL2 COG1061
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
464-770 5.98e-03

Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];


Pssm-ID: 440681 [Multi-domain]  Cd Length: 566  Bit Score: 40.78  E-value: 5.98e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  464 DTILSAIEQ-HPVVVISGDTGCGKTtRIPQLLLERYVTEGRgarcnVIITQPRRISAVSVAQRVSHELGpslrrnvGFQV 542
Cdd:COG1061     90 EALLAALERgGGRGLVVAPTGTGKT-VLALALAAELLRGKR-----VLVLVPRRELLEQWAEELRRFLG-------DPLA 156

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  543 RLESKPPARGGalLFCTVGILLRKLQSNPSLEGVSHVIVDEVHErdVNTDFlliLLKGLQRLNPALRLvLMSAT-----G 617
Cdd:COG1061    157 GGGKKDSDAPI--TVATYQSLARRAHLDELGDRFGLVIIDEAHH--AGAPS---YRRILEAFPAAYRL-GLTATpfrsdG 228

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  618 DNERFSRYFGgcPVIKVP-------GFmypVKEHYLEDILAKLGKHQYPHRHRHHESEDECALDLDLVTDLVLHI-DARG 689
Cdd:COG1061    229 REILLFLFDG--IVYEYSlkeaiedGY---LAPPEYYGIRVDLTDERAEYDALSERLREALAADAERKDKILRELlREHP 303

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  690 EPGGILCFLPGWQEIKGVQQRLQEAlgmhesKYLILPVHSNIPMMDQKAIFQQPPLGVRKIVLATNIAETSITVNDIVHV 769
Cdd:COG1061    304 DDRKTLVFCSSVDHAEALAELLNEA------GIRAAVVTGDTPKKEREEILEAFRDGELRILVTVDVLNEGVDVPRLDVA 377


                   .
gi 1039794335  770 V 770
Cdd:COG1061    378 I 378
AAA_16 pfam13191
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ...
 460-612 7.89e-03

AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 433025 [Multi-domain]  Cd Length: 167  Bit Score: 38.64  E-value: 7.89e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  460 DPHRDTILSAIEQH-----PVVVISGDTGCGKTT---RIPQLLLER--YVTEGRGARCNVIITQPRRISAVSVAQRVSHE 529
Cdd:pfam13191    6 EEELEQLLDALDRVrsgrpPSVLLTGEAGTGKTTllrELLRALERDggYFLRGKCDENLPYSPLLEALTREGLLRQLLDE 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039794335  530 LGPSLRRNVGFQVRLESKP-PARGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTdflLILLKGLQRLNPAL 608
Cdd:pfam13191   86 LESSLLEAWRAALLEALAPvPELPGDLAERLLDLLLRLLDLLARGERPLVLVLDDLQWADEAS---LQLLAALLRLLESL 162


                   ....
gi 1039794335  609 RLVL 612
Cdd:pfam13191  163 PLLV 166
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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