multidrug resistance-associated protein 1 isoform X2 [Mus musculus]
Protein Classification
ABC transporter C family protein( domain architecture ID 1000085)
ATP-binding cassette transporter C (ABCC) family protein similar to human multidrug resistance-associated protein 1 that mediates export of organic anions and drugs from the cytoplasm
List of domain hits
| Name | Accession | Description | Interval | E-value | |||||||||||
| MRP_assoc_pro super family | cl33195 | multi drug resistance-associated protein (MRP); This model describes multi drug ... |
7-773 | 0e+00 | |||||||||||
multi drug resistance-associated protein (MRP); This model describes multi drug resistance-associated protein (MRP) in eukaryotes. The multidrug resistance-associated protein is an integral membrane protein that causes multidrug resistance when overexpressed in mammalian cells. It belongs to ABC transporter superfamily. The protein topology and function was experimentally demonstrated by epitope tagging and immunofluorescence. Insertion of tags in the critical regions associated with drug efflux, abrogated its function. The C-terminal domain seem to highly conserved. [Transport and binding proteins, Other] The actual alignment was detected with superfamily member TIGR00957: Pssm-ID: 188098 [Multi-domain] Cd Length: 1522 Bit Score: 1586.12 E-value: 0e+00
|
|||||||||||||||
| Name | Accession | Description | Interval | E-value | |||||||||||
| MRP_assoc_pro | TIGR00957 | multi drug resistance-associated protein (MRP); This model describes multi drug ... |
7-773 | 0e+00 | |||||||||||
multi drug resistance-associated protein (MRP); This model describes multi drug resistance-associated protein (MRP) in eukaryotes. The multidrug resistance-associated protein is an integral membrane protein that causes multidrug resistance when overexpressed in mammalian cells. It belongs to ABC transporter superfamily. The protein topology and function was experimentally demonstrated by epitope tagging and immunofluorescence. Insertion of tags in the critical regions associated with drug efflux, abrogated its function. The C-terminal domain seem to highly conserved. [Transport and binding proteins, Other] Pssm-ID: 188098 [Multi-domain] Cd Length: 1522 Bit Score: 1586.12 E-value: 0e+00
|
|||||||||||||||
| ABC_6TM_MRP1_2_3_6_D1_like | cd18595 | Six-transmembrane helical domain 1 (TMD1) of multidrug resistance-associated proteins (MRPs) 1, ... |
329-617 | 3.23e-175 | |||||||||||
Six-transmembrane helical domain 1 (TMD1) of multidrug resistance-associated proteins (MRPs) 1, 2, 3 and 6; This group represents the six-transmembrane domain 1 (TMD1) of multidrug resistance-associated proteins (MRPs) 1, 2, 3 and 6, all of which are belonging to the subfamily C of the ATP-binding cassette (ABC) transporter superfamily. The MRP subfamily (ABCC subfamily) is composed of 13 members, of which MRP1 to MRP9 are the major transporters that cause multidrug resistance in tumor cells by pumping anticancer drugs out of the cell. These nine MRP members function as ATP-dependent exporters for endogenous substances and xenobiotics. MRP family can be divided into two groups, depending on their structural architecture. MRP4, MRP5, MRP8, and MRP9 (ABCC4, 5, 11 and 12, respectively) have a typical ABC transporter structure and each composed of two transmembrane domains (TMD1 and TMD2) and two nucleotide domains (NBD1 and NBD2). On the other hand, MRP1, 2, 3, 6 and 7 (ABCC1, 2, 3, 6 and 7, respectively) have an additional N-terminal five transmembrane segments in a single domain (TMD0) connected to the core (TMD-NBD) by a cytoplasmic linker (L0). Pssm-ID: 350039 [Multi-domain] Cd Length: 290 Bit Score: 504.31 E-value: 3.23e-175
|
|||||||||||||||
| PLN03130 | PLN03130 | ABC transporter C family member; Provisional |
103-773 | 1.77e-125 | |||||||||||
ABC transporter C family member; Provisional Pssm-ID: 215595 [Multi-domain] Cd Length: 1622 Bit Score: 411.05 E-value: 1.77e-125
|
|||||||||||||||
| MdlB | COG1132 | ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]; |
313-764 | 7.74e-42 | |||||||||||
ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]; Pssm-ID: 440747 [Multi-domain] Cd Length: 579 Bit Score: 161.49 E-value: 7.74e-42
|
|||||||||||||||
| ABC_membrane | pfam00664 | ABC transporter transmembrane region; This family represents a unit of six transmembrane ... |
326-597 | 6.50e-40 | |||||||||||
ABC transporter transmembrane region; This family represents a unit of six transmembrane helices. Many members of the ABC transporter family (pfam00005) have two such regions. Pssm-ID: 459896 [Multi-domain] Cd Length: 274 Bit Score: 148.56 E-value: 6.50e-40
|
|||||||||||||||
| ABC2_perm_RbbA | NF033858 | ribosome-associated ATPase/putative transporter RbbA; |
661-734 | 5.29e-05 | |||||||||||
ribosome-associated ATPase/putative transporter RbbA; Pssm-ID: 468210 [Multi-domain] Cd Length: 907 Bit Score: 47.04 E-value: 5.29e-05
|
|||||||||||||||
| Name | Accession | Description | Interval | E-value | |||||||||||
| MRP_assoc_pro | TIGR00957 | multi drug resistance-associated protein (MRP); This model describes multi drug ... |
7-773 | 0e+00 | |||||||||||
multi drug resistance-associated protein (MRP); This model describes multi drug resistance-associated protein (MRP) in eukaryotes. The multidrug resistance-associated protein is an integral membrane protein that causes multidrug resistance when overexpressed in mammalian cells. It belongs to ABC transporter superfamily. The protein topology and function was experimentally demonstrated by epitope tagging and immunofluorescence. Insertion of tags in the critical regions associated with drug efflux, abrogated its function. The C-terminal domain seem to highly conserved. [Transport and binding proteins, Other] Pssm-ID: 188098 [Multi-domain] Cd Length: 1522 Bit Score: 1586.12 E-value: 0e+00
|
|||||||||||||||
| ABC_6TM_MRP1_2_3_6_D1_like | cd18595 | Six-transmembrane helical domain 1 (TMD1) of multidrug resistance-associated proteins (MRPs) 1, ... |
329-617 | 3.23e-175 | |||||||||||
Six-transmembrane helical domain 1 (TMD1) of multidrug resistance-associated proteins (MRPs) 1, 2, 3 and 6; This group represents the six-transmembrane domain 1 (TMD1) of multidrug resistance-associated proteins (MRPs) 1, 2, 3 and 6, all of which are belonging to the subfamily C of the ATP-binding cassette (ABC) transporter superfamily. The MRP subfamily (ABCC subfamily) is composed of 13 members, of which MRP1 to MRP9 are the major transporters that cause multidrug resistance in tumor cells by pumping anticancer drugs out of the cell. These nine MRP members function as ATP-dependent exporters for endogenous substances and xenobiotics. MRP family can be divided into two groups, depending on their structural architecture. MRP4, MRP5, MRP8, and MRP9 (ABCC4, 5, 11 and 12, respectively) have a typical ABC transporter structure and each composed of two transmembrane domains (TMD1 and TMD2) and two nucleotide domains (NBD1 and NBD2). On the other hand, MRP1, 2, 3, 6 and 7 (ABCC1, 2, 3, 6 and 7, respectively) have an additional N-terminal five transmembrane segments in a single domain (TMD0) connected to the core (TMD-NBD) by a cytoplasmic linker (L0). Pssm-ID: 350039 [Multi-domain] Cd Length: 290 Bit Score: 504.31 E-value: 3.23e-175
|
|||||||||||||||
| ABC_6TM_ABCC | cd18559 | Six-transmembrane helical domain of the ABC transporters, subfamily C; This group represents ... |
328-617 | 7.28e-133 | |||||||||||
Six-transmembrane helical domain of the ABC transporters, subfamily C; This group represents the 6-transmembrane (6TM) domain of the ABC transporters that belong to the ABCC subfamily, such as the sulphonylurea receptors SUR1/2 (ABCC8), the cystic fibrosis transmembrane conductance regulator (CFTR, ABCC7), Multidrug-Resistance associated Proteins (MRP1-9), VMR1 (vacuolar multidrug resistance protein 1), and YOR1 (yeast oligomycin resistance transporter protein). This TM subunit exhibits the type 3 ATP-binding cassette (ABC) exporter fold, which is characterized by 6 TM helices per subunit (domain), or a total of 12 TM helices for the complete transporter. The type 3 ABC exporters are found in both prokaryotes and eukaryotes, where they mediate the cellular secretion of toxic compounds, a various type of lipids and polypeptides. Pssm-ID: 350003 [Multi-domain] Cd Length: 290 Bit Score: 395.81 E-value: 7.28e-133
|
|||||||||||||||
| PLN03130 | PLN03130 | ABC transporter C family member; Provisional |
103-773 | 1.77e-125 | |||||||||||
ABC transporter C family member; Provisional Pssm-ID: 215595 [Multi-domain] Cd Length: 1622 Bit Score: 411.05 E-value: 1.77e-125
|
|||||||||||||||
| ABC_6TM_ABCC_D1 | cd18579 | Six-transmembrane helical domain 1 (TMD1) of the ABC transporters, subfamily C; This group ... |
329-617 | 2.59e-122 | |||||||||||
Six-transmembrane helical domain 1 (TMD1) of the ABC transporters, subfamily C; This group represents the six-transmembrane domain 1 (TMD1)of the ABC transporters that belong to the ABCC subfamily, such as the sulphonylurea receptors SUR1/2 (ABCC8), the cystic fibrosis transmembrane conductance regulator (CFTR, ABCC7), Multidrug-Resistance associated Proteins (MRP1-9), VMR1 (vacuolar multidrug resistance protein 1), and YOR1 (yeast oligomycin resistance transporter protein). This TM subunit exhibits the type 3 ATP-binding cassette (ABC) exporter fold, which is characterized by 6 TM helices per subunit (domain), or a total of 12 TM helices for the complete transporter. The type 3 ABC exporters are found in both prokaryotes and eukaryotes, where they mediate the cellular secretion of toxic compounds, a various type of lipids and polypeptides. ABC transporters typically consist of two transmembrane domains (TMDs) and two nucleotide-binding domains (NBDs). The two NBDs together bind and hydrolyze ATP, thereby providing the driving force for transport, while the TMDs participate in substrate recognition and translocation across the lipid membrane by alternating between inward- and outward-facing conformations. By contrast, bacterial ABC exporters are typically assembled from dimers of TMD-NBD half-transporters. Thus, most bacterial ABC transporters are comprised of two identical TMDs and two identical NBDs. Pssm-ID: 350023 [Multi-domain] Cd Length: 289 Bit Score: 368.74 E-value: 2.59e-122
|
|||||||||||||||
| PLN03232 | PLN03232 | ABC transporter C family member; Provisional |
206-778 | 5.91e-111 | |||||||||||
ABC transporter C family member; Provisional Pssm-ID: 215640 [Multi-domain] Cd Length: 1495 Bit Score: 369.30 E-value: 5.91e-111
|
|||||||||||||||
| ABC_6TM_VMR1_D1_like | cd18596 | Six-transmembrane helical domain 1 (TMD1) of the yeast Vmr1p, Ybt1p and Nft1; ABCC subfamily; ... |
330-617 | 7.41e-86 | |||||||||||
Six-transmembrane helical domain 1 (TMD1) of the yeast Vmr1p, Ybt1p and Nft1; ABCC subfamily; This group includes the six-transmembrane domain 1 (TMD1) of the yeast Vmr1p, Ybt1p and Nft1, all of which are ABC transporters of the MRP (multidrug resistance-associated protein) subfamily (ABCC). Yeast ABCC (also termed MRP/CFTR) subfamily includes six members (Ycf1p, Bpt1p, Ybt1p/Bat1p, Nft1p, Vmr1p, and Yor1p), of which three members (Ycf1p, Bpt1P and Yor1p) are not included here. While Yor1p, an oligomycin resistance ABC transporter, has been shown to localize to the plasma membrane, the other 4 members (Ycf1p, Bpt1p, Ybt1p/Bat1p, Nft1p and Vmr1p) have been shown to localize to the vacuolar membrane. Ybt1p is originally identified as a bile acid transporter and regulates membrane fusion through Ca2+ transport modulation. Ybt1p also plays a part in ade2 pigment transport. Moreover, Ybt1p has been recently shown to translocate phosphatidylcholine from the outer leaflet of the vacuole to the inner leaflet for degradation and choline recycling. Vmr1p, a vacuolar membrane protein, participates in the export of numerous growth inhibitors from the cell, such as cycloheximide, 2,4-dinitrophenole, cadmium and other toxic metals. Nft1p is not well-characterized, but it is proposed to be regulate Ycf1p, which is involved in heavy metal detoxification. Pssm-ID: 350040 [Multi-domain] Cd Length: 309 Bit Score: 274.37 E-value: 7.41e-86
|
|||||||||||||||
| ABC_6TM_MRP7_D1_like | cd18598 | Six-transmembrane helical domain 1 (TMD1) of multidrug resistance-associated protein 7, and ... |
331-617 | 2.21e-82 | |||||||||||
Six-transmembrane helical domain 1 (TMD1) of multidrug resistance-associated protein 7, and similar proteins; This group represents the six-transmembrane domain 1 (TMD1) of multidrug resistance-associated protein 7 (MRP7), which belongs to the subfamily C of the ATP-binding cassette (ABC) transporter superfamily. The MRP subfamily (ABCC subfamily) is composed of 13 members, of which MRP1 to MRP9 are the major transporters that cause multidrug resistance in tumor cells by pumping anticancer drugs out of the cell. These nine MRP members function as ATP-dependent exporters for endogenous substances and xenobiotics. MRP family can be divided into two groups, depending on their structural architecture. MRP4, MRP5, MRP8, and MRP9 (ABCC4, 5, 11 and 12, respectively) have a typical ABC transporter structure and each composed of two transmembrane domains (TMD1 and TMD2) and two nucleotide domains (NBD1 and NBD2). On the other hand, MRP1, 2, 3, 6 and 7 (ABCC1, 2, 3, 6 and 7, respectively) have an additional N-terminal five transmembrane segments in a single domain (TMD0) connected to the core (TMD-NBD) by a cytoplasmic linker (L0). Pssm-ID: 350042 [Multi-domain] Cd Length: 288 Bit Score: 264.41 E-value: 2.21e-82
|
|||||||||||||||
| ABC_6TM_YOR1_D1_like | cd18597 | Six-transmembrane helical domain 1 (TMD1) of the yeast Yor1p and similar proteins; ABCC ... |
328-617 | 1.22e-79 | |||||||||||
Six-transmembrane helical domain 1 (TMD1) of the yeast Yor1p and similar proteins; ABCC subfamily; This group includes the six-transmembrane domain 1 (TMD1) of the yeast Yor1p, an oligomycin resistance ABC transporter, and similar proteins. Members of this group belong to the MRP (multidrug resistance-associated protein) subfamily (ABCC). In addition to Yor1p, yeast ABCC (also termed MRP/CFTR) subfamily also comprises five other members (Ycf1p, Bpt1p, Ybt1p/Bat1p, Nft1p, and Vmr1p), which are not included in this group. Yor1p is a plasma membrane ATP-binding transporter that mediates export of many different organic anions including oligomycin. While Yor1p has been shown to localize to the plasma membrane, the other 4 members (Ycf1p, Bpt1p, Ybt1p/Bat1p, Nft1p and Vmr1p) have been shown to localize to the vacuolar membrane. Pssm-ID: 350041 [Multi-domain] Cd Length: 293 Bit Score: 257.38 E-value: 1.22e-79
|
|||||||||||||||
| ABC_6TM_SUR1_D1_like | cd18591 | Six-transmembrane helical domain 1 (TMD1) of the sulphonylurea receptors SUR1/2; This group ... |
331-617 | 3.00e-73 | |||||||||||
Six-transmembrane helical domain 1 (TMD1) of the sulphonylurea receptors SUR1/2; This group represents the six-transmembrane domain 1 (TMD1) of the sulphonylurea receptors SUR1/2 (ABCC8), which function as a modulator of ATP-sensitive potassium channels and insulin release, and they belong to the ABCC subfamily. The ATP-sensitive (K-ATP) channel is an octameric complex of four pore-forming Kir6.2 subunits and four regulatory SUR subunits. Thus, in contrast to other ABC transporters, the SUR serves as the regulatory subunit of an ion channel. Mutations and deficiencies in the SUR proteins have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type 2, an autosomal dominant disease of defective insulin secretion. Pssm-ID: 350035 [Multi-domain] Cd Length: 309 Bit Score: 240.99 E-value: 3.00e-73
|
|||||||||||||||
| ABC_6TM_CFTR_D1 | cd18594 | Six-transmembrane helical domain 1 of Cystic Fibrosis Transmembrane Conductance Regulator; ... |
349-617 | 3.36e-67 | |||||||||||
Six-transmembrane helical domain 1 of Cystic Fibrosis Transmembrane Conductance Regulator; This group represents the six-transmembrane domain 1 (TMD1) of the cystic fibrosis transmembrane conductance regulator (CFTR, ABCC7), which belongs to the ABCC subfamily. CFTR functions as a chloride channel, in contrast to other ABC transporters, and controls ion and water secretion and absorption in epithelial tissues. ABC proteins are formed from two homologous halves each containing a transmembrane domain (TMD) and a cytosolic nucleotide binding domain (NBD). In CFTR, these two TMD-NBD halves are linked by the unique regulatory (R) domain, which is not present in other ABC transporters. The ion channel only opens when its R-domain is phosphorylated by cyclic AMP-dependent protein kinase (PKA) and ATP is bound at the NBDs. Mutations in CFTR cause cystic fibrosis, the most common lethal genetic disorder in populations of Northern European descent. Pssm-ID: 350038 [Multi-domain] Cd Length: 291 Bit Score: 224.05 E-value: 3.36e-67
|
|||||||||||||||
| ABC_6TM_MRP4_D1_like | cd18593 | Six-transmembrane helical domain 1 (TMD1) of multidrug resistance-associated protein 4 (MRP4) ... |
362-617 | 3.61e-64 | |||||||||||
Six-transmembrane helical domain 1 (TMD1) of multidrug resistance-associated protein 4 (MRP4) and similar proteins; This group represents the six-transmembrane domain 1 (TMD1) of multidrug resistance-associated protein 4 (MRP4), which belongs to the subfamily C of the ATP-binding cassette (ABC) transporter superfamily. The MRP subfamily (ABCC subfamily) is composed of 13 members, of which MRP1 to MRP9 are the major transporters that cause multidrug resistance in tumor cells by pumping anticancer drugs out of the cell. These nine MRP members function as ATP-dependent exporters for endogenous substances and xenobiotics. MRP family can be divided into two groups, depending on their structural architecture. MRP4, MRP5, MRP8, and MRP9 (ABCC4, 5, 11 and 12, respectively) have a typical ABC transporter structure and each composed of two transmembrane domains (TMD1 and TMD2) and two nucleotide domains (NBD1 and NBD2). On the other hand, MRP1, 2, 3, 6 and 7 (ABCC1, 2, 3, 6 and 7, respectively) have an additional N-terminal five transmembrane segments in a single domain (TMD0) connected to the core (TMD-NBD) by a cytoplasmic linker (L0). Pssm-ID: 350037 [Multi-domain] Cd Length: 291 Bit Score: 215.93 E-value: 3.61e-64
|
|||||||||||||||
| PTZ00243 | PTZ00243 | ABC transporter; Provisional |
291-764 | 2.61e-63 | |||||||||||
ABC transporter; Provisional Pssm-ID: 240327 [Multi-domain] Cd Length: 1560 Bit Score: 231.21 E-value: 2.61e-63
|
|||||||||||||||
| ABCC_MRP_domain1 | cd03250 | ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C; This ... |
644-764 | 4.09e-61 | |||||||||||
ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C; This subfamily is also known as MRP (multidrug resistance-associated protein). Some of the MRP members have five additional transmembrane segments in their N-terminus, but the function of these additional membrane-spanning domains is not clear. The MRP was found in the multidrug-resisting lung cancer cell in which p-glycoprotein was not overexpressed. MRP exports glutathione by drug stimulation, as well as, certain substrates in conjugated forms with anions, such as glutathione, glucuronate, and sulfate. Pssm-ID: 213217 [Multi-domain] Cd Length: 204 Bit Score: 204.63 E-value: 4.09e-61
|
|||||||||||||||
| ABC_6TM_MRP5_8_9_D1 | cd18592 | Six-transmembrane helical domain 1 (TMD1) of multidrug resistance-associated proteins (MRPs) 5, ... |
341-617 | 2.21e-52 | |||||||||||
Six-transmembrane helical domain 1 (TMD1) of multidrug resistance-associated proteins (MRPs) 5, 8, and 9; This group represents the six-transmembrane domain 1 (TMD1) of multidrug resistance-associated proteins (MRPs) 5, 8, and 9, all of which are belonging to the subfamily C of the ATP-binding cassette (ABC) transporter superfamily. The MRP subfamily (ABCC subfamily) is composed of 13 members, of which MRP1 to MRP9 are the major transporters that cause multidrug resistance in tumor cells by pumping anticancer drugs out of the cell. These nine MRP members function as ATP-dependent exporters for endogenous substances and xenobiotics. MRP family can be divided into two groups, depending on their structural architecture. MRP4, MRP5, MRP8, and MRP9 (ABCC4, 5, 11 and 12, respectively) have a typical ABC transporter structure and each composed of two transmembrane domains (TMD1 and TMD2) and two nucleotide domains (NBD1 and NBD2). On the other hand, MRP1, 2, 3, 6 and 7 (ABCC1, 2, 3, 6 and 7, respectively) have an additional N-terminal five transmembrane segments in a single domain (TMD0) connected to the core (TMD-NBD) by a cytoplasmic linker (L0). Pssm-ID: 350036 [Multi-domain] Cd Length: 287 Bit Score: 183.92 E-value: 2.21e-52
|
|||||||||||||||
| CFTR_protein | TIGR01271 | cystic fibrosis transmembrane conductor regulator (CFTR); The model describes the cystis ... |
209-775 | 8.84e-52 | |||||||||||
cystic fibrosis transmembrane conductor regulator (CFTR); The model describes the cystis fibrosis transmembrane conductor regulator (CFTR) in eukaryotes. The principal role of this protein is chloride ion conductance. The protein is predicted to consist of 12 transmembrane domains. Mutations or lesions in the genetic loci have been linked to the aetiology of asthma, bronchiectasis, chronic obstructive pulmonary disease etc. Disease-causing mutations have been studied by 36Cl efflux assays in vitro cell cultures and electrophysiology, all of which point to the impairment of chloride channel stability and not the biosynthetic processing per se. [Transport and binding proteins, Anions] Pssm-ID: 273530 [Multi-domain] Cd Length: 1490 Bit Score: 196.28 E-value: 8.84e-52
|
|||||||||||||||
| MdlB | COG1132 | ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]; |
313-764 | 7.74e-42 | |||||||||||
ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]; Pssm-ID: 440747 [Multi-domain] Cd Length: 579 Bit Score: 161.49 E-value: 7.74e-42
|
|||||||||||||||
| ABC_membrane | pfam00664 | ABC transporter transmembrane region; This family represents a unit of six transmembrane ... |
326-597 | 6.50e-40 | |||||||||||
ABC transporter transmembrane region; This family represents a unit of six transmembrane helices. Many members of the ABC transporter family (pfam00005) have two such regions. Pssm-ID: 459896 [Multi-domain] Cd Length: 274 Bit Score: 148.56 E-value: 6.50e-40
|
|||||||||||||||
| ABCC_SUR1_N | cd03290 | ATP-binding cassette domain of the sulfonylurea receptor, subfamily C; The SUR domain 1. The ... |
644-775 | 2.59e-36 | |||||||||||
ATP-binding cassette domain of the sulfonylurea receptor, subfamily C; The SUR domain 1. The sulfonylurea receptor SUR is an ATP transporter of the ABCC/MRP family with tandem ATPase binding domains. Unlike other ABC proteins, it has no intrinsic transport function, neither active nor passive, but associates with the potassium channel proteins Kir6.1 or Kir6.2 to form the ATP-sensitive potassium (K(ATP)) channel. Within the channel complex, SUR serves as a regulatory subunit that fine-tunes the gating of Kir6.x in response to alterations in cellular metabolism. It constitutes a major pharmaceutical target as it binds numerous drugs, K(ATP) channel openers and blockers, capable of up- or down-regulating channel activity. Pssm-ID: 213257 [Multi-domain] Cd Length: 218 Bit Score: 136.31 E-value: 2.59e-36
|
|||||||||||||||
| SunT | COG2274 | ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase ... |
308-763 | 9.40e-34 | |||||||||||
ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Pssm-ID: 441875 [Multi-domain] Cd Length: 711 Bit Score: 138.43 E-value: 9.40e-34
|
|||||||||||||||
| CydD | COG4988 | ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease ... |
620-763 | 5.02e-22 | |||||||||||
ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion, Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 444012 [Multi-domain] Cd Length: 563 Bit Score: 100.99 E-value: 5.02e-22
|
|||||||||||||||
| ABC_6TM_exporters | cd07346 | Six-transmembrane helical domain of the ATP-binding cassette transporters; This family ... |
338-617 | 7.38e-22 | |||||||||||
Six-transmembrane helical domain of the ATP-binding cassette transporters; This family represents a subunit of six transmembrane (TM) helices typically found in the ATP-binding cassette (ABC) transporters that function as exporters, which contain 6 TM helices per subunit (domain), or a total of 12 TM helices for the complete transporter. The ABC exporters are found in both prokaryotes and eukaryotes, where they mediate the cellular secretion of toxic compounds and a various type of lipids. In addition to ABC exporters, ABC transporters include two classes of ABC importers, classified depending on details of their architecture and mechanism. Only the ABC exporters are included in this family. ABC transporters typically consist of two transmembrane domains (TMDs) and two nucleotide-binding domains (NBDs). The sequences and structures of the TMDs are quite varied between the different type of transporters, suggesting chemical diversity of the translocated substrates, whereas NBDs are conserved among all ABC transporters. The two NBDs together bind and hydrolyze ATP, thereby providing the driving force for transport, while the TMDs participate in substrate recognition and translocation across the lipid membrane. However, some ABC genes are organized as half-transporters, which must form either homodimers or heterodimers to form a functional unit. The ABC exporters play a role in multidrug resistance to antibiotics and anticancer agents, and mutations in these proteins have been shown to cause severe human diseases such as cystic fibrosis. Pssm-ID: 349983 [Multi-domain] Cd Length: 292 Bit Score: 96.47 E-value: 7.38e-22
|
|||||||||||||||
| ABCC_MRP_Like | cd03228 | ATP-binding cassette domain of multidrug resistance protein-like transporters; The MRP ... |
644-727 | 3.44e-21 | |||||||||||
ATP-binding cassette domain of multidrug resistance protein-like transporters; The MRP (Multidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a diverse functional spectrum that includes ion transport, cell surface receptor, and toxin secretion activities. The MRP-like family, similar to all ABC proteins, have a common four-domain core structure constituted by two membrane-spanning domains, each composed of six transmembrane (TM) helices, and two nucleotide-binding domains (NBD). ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213195 [Multi-domain] Cd Length: 171 Bit Score: 91.29 E-value: 3.44e-21
|
|||||||||||||||
| ABCC_CFTR1 | cd03291 | ATP-binding cassette domain of the cystic fibrosis transmembrane regulator, subfamily C; The ... |
659-775 | 5.21e-21 | |||||||||||
ATP-binding cassette domain of the cystic fibrosis transmembrane regulator, subfamily C; The CFTR subfamily domain 1. The cystic fibrosis transmembrane regulator (CFTR), the product of the gene mutated in patients with cystic fibrosis, has adapted the ABC transporter structural motif to form a tightly regulated anion channel at the apical surface of many epithelia. Use of the term assembly of a functional ion channel implies the coming together of subunits, or at least smaller not-yet functional components of the active whole. In fact, on the basis of current knowledge only the CFTR polypeptide itself is required to form an ATP- and protein kinase A-dependent low-conductance chloride channel of the type present in the apical membrane of many epithelial cells. CFTR displays the typical organization (IM-ABC)2 and carries a characteristic hydrophilic R-domain that separates IM1-ABC1 from IM2-ABC2. Pssm-ID: 213258 [Multi-domain] Cd Length: 282 Bit Score: 93.77 E-value: 5.21e-21
|
|||||||||||||||
| CydD | TIGR02857 | thiol reductant ABC exporter, CydD subunit; The gene pair cydCD encodes an ABC-family ... |
450-763 | 1.06e-18 | |||||||||||
thiol reductant ABC exporter, CydD subunit; The gene pair cydCD encodes an ABC-family transporter in which each gene contains an N-terminal membrane-spanning domain (pfam00664) and a C-terminal ATP-binding domain (pfam00005). In E. coli these genes were discovered as mutants which caused the terminal heme-copper oxidase complex cytochrome bd to fail to assemble. Recent work has shown that the transporter is involved in export of redox-active thiol compounds such as cysteine and glutathione. The linkage to assembly of the cytochrome bd complex is further supported by the conserved operon structure found outside the gammaproteobacteria (cydABCD) containing both the transporter and oxidase genes components. The genes used as the seed members for this model are all either found in the gammproteobacterial context or the CydABCD context. All members of this family scoring above trusted at the time of its creation were from genomes which encode a cytochrome bd complex. Unfortunately, the gene symbol nomenclature adopted based on this operon in B. subtilis assigns cydC to the third gene in the operon where this gene is actually homologous to the E. coli cydD gene. We have chosen to name all homologs in this family in accordance with the precedence of publication of the E. coli name, CydD Pssm-ID: 274323 [Multi-domain] Cd Length: 529 Bit Score: 90.42 E-value: 1.06e-18
|
|||||||||||||||
| ABCC_Glucan_exporter_like | cd03254 | ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Glucan ... |
644-764 | 2.68e-16 | |||||||||||
ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virulence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and lipid export. The MRP-like family, similar to all ABC proteins, have a common four-domain core structure constituted by two membrane-spanning domains each composed of six transmembrane (TM) helices and two nucleotide-binding domains (NBD). ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213221 [Multi-domain] Cd Length: 229 Bit Score: 78.81 E-value: 2.68e-16
|
|||||||||||||||
| ABCC_Protease_Secretion | cd03246 | ATP-binding cassette domain of PrtD, subfamily C; This family represents the ABC component of ... |
644-729 | 1.49e-15 | |||||||||||
ATP-binding cassette domain of PrtD, subfamily C; This family represents the ABC component of the protease secretion system PrtD, a 60-kDa integral membrane protein sharing 37% identity with HlyB, the ABC component of the alpha-hemolysin secretion pathway, in the C-terminal domain. They export degradative enzymes by using a type I protein secretion system and lack an N-terminal signal peptide, but contain a C-terminal secretion signal. The Type I secretion apparatus is made up of three components, an ABC transporter, a membrane fusion protein (MFP), and an outer membrane protein (OMP). For the HlyA transporter complex, HlyB (ABC transporter) and HlyD (MFP) reside in the inner membrane of E. coli. The OMP component is TolC, which is thought to interact with the MFP to form a continuous channel across the periplasm from the cytoplasm to the exterior. HlyB belongs to the family of ABC transporters, which are ubiquitous, ATP-dependent transmembrane pumps or channels. The spectrum of transport substrates ranges from inorganic ions, nutrients such as amino acids, sugars, or peptides, hydrophobic drugs, to large polypeptides, such as HlyA. Pssm-ID: 213213 [Multi-domain] Cd Length: 173 Bit Score: 74.95 E-value: 1.49e-15
|
|||||||||||||||
| ABCC_MsbA | cd03251 | ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; ... |
644-764 | 2.14e-15 | |||||||||||
ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213218 [Multi-domain] Cd Length: 234 Bit Score: 76.12 E-value: 2.14e-15
|
|||||||||||||||
| ABC_MTABC3_MDL1_MDL2 | cd03249 | ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; MTABC3 ... |
644-764 | 1.09e-14 | |||||||||||
ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1. In fact, the yeast MDL1 (multidrug resistance-like protein 1) and MDL2 (multidrug resistance-like protein 2) transporters are also included in this CD. MDL1 is an ATP-dependent permease that acts as a high-copy suppressor of ATM1 and is thought to have a role in resistance to oxidative stress. Interestingly, subfamily B is more closely related to the carboxyl-terminal component of subfamily C than the two halves of ABCC molecules are with one another. Pssm-ID: 213216 [Multi-domain] Cd Length: 238 Bit Score: 74.11 E-value: 1.09e-14
|
|||||||||||||||
| ABC_tran | pfam00005 | ABC transporter; ABC transporters for a large family of proteins responsible for translocation ... |
661-739 | 2.17e-14 | |||||||||||
ABC transporter; ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are composed of two copies of this domain and two copies of a transmembrane domain pfam00664. These four domains may belong to a single polypeptide or belong in different polypeptide chains. Pssm-ID: 394964 [Multi-domain] Cd Length: 150 Bit Score: 71.14 E-value: 2.17e-14
|
|||||||||||||||
| ZnuC | COG1121 | ABC-type Mn2+/Zn2+ transport system, ATPase component [Inorganic ion transport and metabolism]; ... |
644-715 | 2.89e-14 | |||||||||||
ABC-type Mn2+/Zn2+ transport system, ATPase component [Inorganic ion transport and metabolism]; Pssm-ID: 440738 [Multi-domain] Cd Length: 245 Bit Score: 73.20 E-value: 2.89e-14
|
|||||||||||||||
| ABCC_bacteriocin_exporters | cd03245 | ATP-binding cassette domain of bacteriocin exporters, subfamily C; Many non-lantibiotic ... |
643-764 | 7.37e-14 | |||||||||||
ATP-binding cassette domain of bacteriocin exporters, subfamily C; Many non-lantibiotic bacteriocins of lactic acid bacteria are produced as precursors which have N-terminal leader peptides that share similarities in amino acid sequence and contain a conserved processing site of two glycine residues in positions -1 and -2. A dedicated ATP-binding cassette (ABC) transporter is responsible for the proteolytic cleavage of the leader peptides and subsequent translocation of the bacteriocins across the cytoplasmic membrane. Pssm-ID: 213212 [Multi-domain] Cd Length: 220 Bit Score: 71.47 E-value: 7.37e-14
|
|||||||||||||||
| ABCC_MRP_domain2 | cd03244 | ATP-binding cassette domain 2 of multidrug resistance-associated protein; The ABC subfamily C ... |
643-769 | 1.53e-13 | |||||||||||
ATP-binding cassette domain 2 of multidrug resistance-associated protein; The ABC subfamily C is also known as MRP (multidrug resistance-associated protein). Some of the MRP members have five additional transmembrane segments in their N-terminus, but the function of these additional membrane-spanning domains is not clear. The MRP was found in the multidrug-resistance lung cancer cell in which p-glycoprotein was not overexpressed. MRP exports glutathione by drug stimulation, as well as, certain substrates in conjugated forms with anions, such as glutathione, glucuronate, and sulfate. Pssm-ID: 213211 [Multi-domain] Cd Length: 221 Bit Score: 70.60 E-value: 1.53e-13
|
|||||||||||||||
| PRK11160 | PRK11160 | cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed |
643-731 | 2.94e-13 | |||||||||||
cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed Pssm-ID: 236865 [Multi-domain] Cd Length: 574 Bit Score: 73.32 E-value: 2.94e-13
|
|||||||||||||||
| ABC_NrtD_SsuB_transporters | cd03293 | ATP-binding cassette domain of the nitrate and sulfonate transporters; NrtD and SsuB are the ... |
644-729 | 5.90e-12 | |||||||||||
ATP-binding cassette domain of the nitrate and sulfonate transporters; NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213260 [Multi-domain] Cd Length: 220 Bit Score: 65.96 E-value: 5.90e-12
|
|||||||||||||||
| ABC_cobalt_CbiO_domain1 | cd03225 | First domain of the ATP-binding cassette component of cobalt transport system; Domain I of the ... |
646-729 | 8.60e-12 | |||||||||||
First domain of the ATP-binding cassette component of cobalt transport system; Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC transport system of the CbiMNQO family is involved in cobalt transport in association with the cobalamin (vitamin B12) biosynthetic pathways. Most of cobalt (Cbi) transport systems possess a separate CbiN component, the cobalt-binding periplasmic protein, and they are encoded by the conserved gene cluster cbiMNQO. Both the CbiM and CbiQ proteins are integral cytoplasmic membrane proteins, and the CbiO protein has the linker peptide and the Walker A and B motifs commonly found in the ATPase components of the ABC-type transport systems. Pssm-ID: 213192 [Multi-domain] Cd Length: 211 Bit Score: 65.18 E-value: 8.60e-12
|
|||||||||||||||
| PRK11176 | PRK11176 | lipid A ABC transporter ATP-binding protein/permease MsbA; |
634-773 | 1.10e-11 | |||||||||||
lipid A ABC transporter ATP-binding protein/permease MsbA; Pssm-ID: 183016 [Multi-domain] Cd Length: 582 Bit Score: 68.12 E-value: 1.10e-11
|
|||||||||||||||
| PRK11174 | PRK11174 | cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed |
620-769 | 2.06e-11 | |||||||||||
cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed Pssm-ID: 236870 [Multi-domain] Cd Length: 588 Bit Score: 67.18 E-value: 2.06e-11
|
|||||||||||||||
| ABC_Metallic_Cations | cd03235 | ATP-binding cassette domain of the metal-type transporters; This family includes transporters ... |
646-743 | 4.32e-11 | |||||||||||
ATP-binding cassette domain of the metal-type transporters; This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-siderophore uptake family suggesting that they share a common ancestor. The best characterized metal-type ABC transporters are the YfeABCD system of Y. pestis, the SitABCD system of Salmonella enterica serovar Typhimurium, and the SitABCD transporter of Shigella flexneri. Moreover other uncharacterized homologs of these metal-type transporters are mainly found in pathogens like Haemophilus or enteroinvasive E. coli isolates. Pssm-ID: 213202 [Multi-domain] Cd Length: 213 Bit Score: 63.32 E-value: 4.32e-11
|
|||||||||||||||
| ABC_MJ0796_LolCDE_FtsE | cd03255 | ATP-binding cassette domain of the transporters involved in export of lipoprotein and ... |
644-728 | 5.67e-11 | |||||||||||
ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and Cell division ATP-binding protein FtsE; This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. The FtsEX complex resembles an ABC transporter, where FtsE is the ATPase and the membrane subunit FtsX resembles a permease subunit. But rather than transporting any substrate, the complex acts in cell division by undergoing conformational changes that alter the activity of cell wall hydrolases located outside the plasma membrane. The complex is widely conserved in bacteria, but also extremely divergent in sequence between different lineages. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane. Pssm-ID: 213222 [Multi-domain] Cd Length: 218 Bit Score: 62.89 E-value: 5.67e-11
|
|||||||||||||||
| PRK10790 | PRK10790 | SmdB family multidrug efflux ABC transporter permease/ATP-binding protein; |
634-774 | 6.73e-11 | |||||||||||
SmdB family multidrug efflux ABC transporter permease/ATP-binding protein; Pssm-ID: 182733 [Multi-domain] Cd Length: 592 Bit Score: 65.51 E-value: 6.73e-11
|
|||||||||||||||
| ATM1 | COG5265 | ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components ... |
596-766 | 8.40e-11 | |||||||||||
ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 444078 [Multi-domain] Cd Length: 605 Bit Score: 65.23 E-value: 8.40e-11
|
|||||||||||||||
| ABC_ATPase | cd00267 | ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large ... |
645-713 | 5.83e-10 | |||||||||||
ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide-binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213179 [Multi-domain] Cd Length: 157 Bit Score: 58.41 E-value: 5.83e-10
|
|||||||||||||||
| ABCC_NFT1 | cd03369 | ATP-binding cassette domain 2 of NFT1, subfamily C; Domain 2 of NFT1 (New full-length MRP-type ... |
643-772 | 1.99e-09 | |||||||||||
ATP-binding cassette domain 2 of NFT1, subfamily C; Domain 2 of NFT1 (New full-length MRP-type transporter 1). NFT1 belongs to the MRP (multidrug resistance-associated protein) family of ABC transporters. Some of the MRP members have five additional transmembrane segments in their N-terminus, but the function of these additional membrane-spanning domains is not clear. The MRP was found in the multidrug-resisting lung cancer cell in which p-glycoprotein was not overexpressed. MRP exports glutathione by drug stimulation, as well as, certain substrates in conjugated forms with anions such as glutathione, glucuronate, and sulfate. Pssm-ID: 213269 [Multi-domain] Cd Length: 207 Bit Score: 58.19 E-value: 1.99e-09
|
|||||||||||||||
| PRK13657 | PRK13657 | glucan ABC transporter ATP-binding protein/ permease; |
583-774 | 2.29e-09 | |||||||||||
glucan ABC transporter ATP-binding protein/ permease; Pssm-ID: 184214 [Multi-domain] Cd Length: 588 Bit Score: 60.75 E-value: 2.29e-09
|
|||||||||||||||
| YddA | COG4178 | ABC-type uncharacterized transport system, permease and ATPase components [General function ... |
590-750 | 3.01e-09 | |||||||||||
ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Pssm-ID: 443337 [Multi-domain] Cd Length: 571 Bit Score: 60.21 E-value: 3.01e-09
|
|||||||||||||||
| GsiA | COG1123 | ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain ... |
644-729 | 3.18e-09 | |||||||||||
ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain [Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 440740 [Multi-domain] Cd Length: 514 Bit Score: 60.30 E-value: 3.18e-09
|
|||||||||||||||
| PRK10789 | PRK10789 | SmdA family multidrug ABC transporter permease/ATP-binding protein; |
597-775 | 5.62e-09 | |||||||||||
SmdA family multidrug ABC transporter permease/ATP-binding protein; Pssm-ID: 182732 [Multi-domain] Cd Length: 569 Bit Score: 59.34 E-value: 5.62e-09
|
|||||||||||||||
| Uup | COG0488 | ATPase components of ABC transporters with duplicated ATPase domains [General function ... |
652-751 | 1.66e-08 | |||||||||||
ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Pssm-ID: 440254 [Multi-domain] Cd Length: 520 Bit Score: 57.77 E-value: 1.66e-08
|
|||||||||||||||
| 3a01208 | TIGR00958 | Conjugate Transporter-2 (CT2) Family protein; [Transport and binding proteins, Other] |
644-775 | 3.01e-08 | |||||||||||
Conjugate Transporter-2 (CT2) Family protein; [Transport and binding proteins, Other] Pssm-ID: 273363 [Multi-domain] Cd Length: 711 Bit Score: 57.42 E-value: 3.01e-08
|
|||||||||||||||
| ABC_NikE_OppD_transporters | cd03257 | ATP-binding cassette domain of nickel/oligopeptides specific transporters; The ABC transporter ... |
644-713 | 3.31e-08 | |||||||||||
ATP-binding cassette domain of nickel/oligopeptides specific transporters; The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane components (NikB and NikC), and two ATPase (NikD and NikE). The NikABCDE transporter is synthesized under anaerobic conditions to meet the increased demand for nickel resulting from hydrogenase synthesis. The molecular mechanism of nickel uptake in many bacteria and most archaea is not known. Many other members of this ABC family are also involved in the uptake of dipeptides and oligopeptides. The oligopeptide transport system (Opp) is a five-component ABC transport composed of a membrane-anchored substrate binding proteins (SRP), OppA, two transmembrane proteins, OppB and OppC, and two ATP-binding domains, OppD and OppF. Pssm-ID: 213224 [Multi-domain] Cd Length: 228 Bit Score: 54.82 E-value: 3.31e-08
|
|||||||||||||||
| CcmA | COG4133 | ABC-type transport system involved in cytochrome c biogenesis, ATPase component ... |
644-728 | 7.53e-08 | |||||||||||
ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 443308 [Multi-domain] Cd Length: 206 Bit Score: 53.64 E-value: 7.53e-08
|
|||||||||||||||
| ABC_PstB_phosphate_transporter | cd03260 | ATP-binding cassette domain of the phosphate transport system; Phosphate uptake is of ... |
644-731 | 1.38e-07 | |||||||||||
ATP-binding cassette domain of the phosphate transport system; Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein is a phosphate-binding protein located in the periplasmic space. PstA and PstC are hydrophobic and they form the transmembrane portion of the Pst system. PstB is the catalytic subunit, which couples the energy of ATP hydrolysis to the import of phosphate across cellular membranes through the Pst system, often referred as ABC-protein. PstB belongs to one of the largest superfamilies of proteins characterized by a highly conserved adenosine triphosphate (ATP) binding cassette (ABC), which is also a nucleotide binding domain (NBD). Pssm-ID: 213227 [Multi-domain] Cd Length: 227 Bit Score: 52.95 E-value: 1.38e-07
|
|||||||||||||||
| PLN03232 | PLN03232 | ABC transporter C family member; Provisional |
395-726 | 2.59e-07 | |||||||||||
ABC transporter C family member; Provisional Pssm-ID: 215640 [Multi-domain] Cd Length: 1495 Bit Score: 54.60 E-value: 2.59e-07
|
|||||||||||||||
| GsiA | COG1123 | ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain ... |
644-706 | 2.95e-07 | |||||||||||
ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain [Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 440740 [Multi-domain] Cd Length: 514 Bit Score: 53.75 E-value: 2.95e-07
|
|||||||||||||||
| ABC_Org_Solvent_Resistant | cd03261 | ATP-binding cassette transport system involved in resistance to organic solvents; ABC ... |
644-706 | 4.19e-07 | |||||||||||
ATP-binding cassette transport system involved in resistance to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213228 [Multi-domain] Cd Length: 235 Bit Score: 51.73 E-value: 4.19e-07
|
|||||||||||||||
| ABCG_EPDR | cd03213 | Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette ... |
643-728 | 4.61e-07 | |||||||||||
Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; ABCG transporters are involved in eye pigment (EP) precursor transport, regulation of lipid-trafficking mechanisms, and pleiotropic drug resistance (DR). DR is a well-described phenomenon occurring in fungi and shares several similarities with processes in bacteria and higher eukaryotes. Compared to other members of the ABC transporter subfamilies, the ABCG transporter family is composed of proteins that have an ATP-binding cassette domain at the N-terminus and a TM (transmembrane) domain at the C-terminus. Pssm-ID: 213180 [Multi-domain] Cd Length: 194 Bit Score: 51.01 E-value: 4.61e-07
|
|||||||||||||||
| Uup | COG0488 | ATPase components of ABC transporters with duplicated ATPase domains [General function ... |
614-725 | 4.83e-07 | |||||||||||
ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Pssm-ID: 440254 [Multi-domain] Cd Length: 520 Bit Score: 53.14 E-value: 4.83e-07
|
|||||||||||||||
| ssuB | PRK11247 | aliphatic sulfonates transport ATP-binding subunit; Provisional |
656-707 | 5.29e-07 | |||||||||||
aliphatic sulfonates transport ATP-binding subunit; Provisional Pssm-ID: 183055 [Multi-domain] Cd Length: 257 Bit Score: 51.60 E-value: 5.29e-07
|
|||||||||||||||
| ABCC_Hemolysin | cd03252 | ATP-binding cassette domain of hemolysin B, subfamily C; The ABC-transporter hemolysin B is a ... |
644-775 | 8.23e-07 | |||||||||||
ATP-binding cassette domain of hemolysin B, subfamily C; The ABC-transporter hemolysin B is a central component of the secretion machinery that translocates the toxin, hemolysin A, in a Sec-independent fashion across both membranes of E. coli. The hemolysin A (HlyA) transport machinery is composed of the ATP-binding cassette (ABC) transporter HlyB located in the inner membrane, hemolysin D (HlyD), also anchored in the inner membrane, and TolC, which resides in the outer membrane. HlyD apparently forms a continuous channel that bridges the entire periplasm, interacting with TolC and HlyB. This arrangement prevents the appearance of periplasmic intermediates of HlyA during substrate transport. Little is known about the molecular details of HlyA transport, but it is evident that ATP-hydrolysis by the ABC-transporter HlyB is a necessary source of energy. Pssm-ID: 213219 [Multi-domain] Cd Length: 237 Bit Score: 50.95 E-value: 8.23e-07
|
|||||||||||||||
| ABC_Class3 | cd03229 | ATP-binding cassette domain of the binding protein-dependent transport systems; This class is ... |
644-729 | 1.03e-06 | |||||||||||
ATP-binding cassette domain of the binding protein-dependent transport systems; This class is comprised of all BPD (Binding Protein Dependent) systems that are largely represented in archaea and eubacteria and are primarily involved in scavenging solutes from the environment. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213196 [Multi-domain] Cd Length: 178 Bit Score: 49.49 E-value: 1.03e-06
|
|||||||||||||||
| PRK15056 | PRK15056 | manganese/iron ABC transporter ATP-binding protein; |
643-713 | 1.09e-06 | |||||||||||
manganese/iron ABC transporter ATP-binding protein; Pssm-ID: 185016 [Multi-domain] Cd Length: 272 Bit Score: 51.04 E-value: 1.09e-06
|
|||||||||||||||
| ABCC_TAP | cd03248 | ATP-binding cassette domain of the Transporter Associated with Antigen Processing, subfamily C; ... |
647-775 | 1.73e-06 | |||||||||||
ATP-binding cassette domain of the Transporter Associated with Antigen Processing, subfamily C; TAP (Transporter Associated with Antigen Processing) is essential for peptide delivery from the cytosol into the lumen of the endoplasmic reticulum (ER), where these peptides are loaded on major histocompatibility complex (MHC) I molecules. Loaded MHC I leave the ER and display their antigenic cargo on the cell surface to cytotoxic T cells. Subsequently, virus-infected or malignantly transformed cells can be eliminated. TAP belongs to the large family of ATP-binding cassette (ABC) transporters, which translocate a vast variety of solutes across membranes. Pssm-ID: 213215 [Multi-domain] Cd Length: 226 Bit Score: 49.78 E-value: 1.73e-06
|
|||||||||||||||
| cbiO | PRK13640 | energy-coupling factor transporter ATPase; |
642-706 | 1.75e-06 | |||||||||||
energy-coupling factor transporter ATPase; Pssm-ID: 184200 [Multi-domain] Cd Length: 282 Bit Score: 50.57 E-value: 1.75e-06
|
|||||||||||||||
| ABCC_CFTR2 | cd03289 | ATP-binding cassette domain 2 of CFTR,subfamily C; The cystic fibrosis transmembrane regulator ... |
644-726 | 1.89e-06 | |||||||||||
ATP-binding cassette domain 2 of CFTR,subfamily C; The cystic fibrosis transmembrane regulator (CFTR), the product of the gene mutated in patients with cystic fibrosis, has adapted the ABC transporter structural motif to form a tightly regulated anion channel at the apical surface of many epithelia. Use of the term assembly of a functional ion channel implies the coming together of subunits or at least smaller not-yet functional components of the active whole. In fact, on the basis of current knowledge only the CFTR polypeptide itself is required to form an ATP- and protein kinase A-dependent low-conductance chloride channel of the type present in the apical membrane of many epithelial cells. CFTR displays the typical organization (IM-ABC)2 and carries a characteristic hydrophilic R-domain that separates IM1-ABC1 from IM2-ABC2. Pssm-ID: 213256 [Multi-domain] Cd Length: 275 Bit Score: 50.24 E-value: 1.89e-06
|
|||||||||||||||
| ABC_CysA_sulfate_importer | cd03296 | ATP-binding cassette domain of the sulfate transporter; Part of the ABC transporter complex ... |
643-729 | 2.01e-06 | |||||||||||
ATP-binding cassette domain of the sulfate transporter; Part of the ABC transporter complex cysAWTP involved in sulfate import. Responsible for energy coupling to the transport system. The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a solute-binding protein (cysP). ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213263 [Multi-domain] Cd Length: 239 Bit Score: 49.65 E-value: 2.01e-06
|
|||||||||||||||
| cbiO | PRK13632 | cobalt transporter ATP-binding subunit; Provisional |
644-692 | 3.15e-06 | |||||||||||
cobalt transporter ATP-binding subunit; Provisional Pssm-ID: 237452 [Multi-domain] Cd Length: 271 Bit Score: 49.60 E-value: 3.15e-06
|
|||||||||||||||
| btuD | PRK09536 | corrinoid ABC transporter ATPase; Reviewed |
644-715 | 5.86e-06 | |||||||||||
corrinoid ABC transporter ATPase; Reviewed Pssm-ID: 236554 [Multi-domain] Cd Length: 402 Bit Score: 49.45 E-value: 5.86e-06
|
|||||||||||||||
| PRK10253 | PRK10253 | iron-enterobactin ABC transporter ATP-binding protein; |
655-706 | 6.80e-06 | |||||||||||
iron-enterobactin ABC transporter ATP-binding protein; Pssm-ID: 182336 [Multi-domain] Cd Length: 265 Bit Score: 48.44 E-value: 6.80e-06
|
|||||||||||||||
| PRK14258 | PRK14258 | phosphate ABC transporter ATP-binding protein; Provisional |
643-731 | 8.00e-06 | |||||||||||
phosphate ABC transporter ATP-binding protein; Provisional Pssm-ID: 184593 [Multi-domain] Cd Length: 261 Bit Score: 48.11 E-value: 8.00e-06
|
|||||||||||||||
| CFTR_protein | TIGR01271 | cystic fibrosis transmembrane conductor regulator (CFTR); The model describes the cystis ... |
641-726 | 1.13e-05 | |||||||||||
cystic fibrosis transmembrane conductor regulator (CFTR); The model describes the cystis fibrosis transmembrane conductor regulator (CFTR) in eukaryotes. The principal role of this protein is chloride ion conductance. The protein is predicted to consist of 12 transmembrane domains. Mutations or lesions in the genetic loci have been linked to the aetiology of asthma, bronchiectasis, chronic obstructive pulmonary disease etc. Disease-causing mutations have been studied by 36Cl efflux assays in vitro cell cultures and electrophysiology, all of which point to the impairment of chloride channel stability and not the biosynthetic processing per se. [Transport and binding proteins, Anions] Pssm-ID: 273530 [Multi-domain] Cd Length: 1490 Bit Score: 49.14 E-value: 1.13e-05
|
|||||||||||||||
| ABC_KpsT_Wzt | cd03220 | ATP-binding cassette component of polysaccharide transport system; The KpsT/Wzt ABC ... |
634-728 | 1.14e-05 | |||||||||||
ATP-binding cassette component of polysaccharide transport system; The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and teichoic acids have been shown to be exported by ABC transporters. A typical system is made of a conserved integral membrane and an ABC. In addition to these proteins, capsular polysaccharide exporter systems require two 'accessory' proteins to perform their function: a periplasmic (E.coli) or a lipid-anchored outer membrane protein called OMA (Neisseria meningitidis and Haemophilus influenza) and a cytoplasmic membrane protein MPA2. Pssm-ID: 213187 [Multi-domain] Cd Length: 224 Bit Score: 47.14 E-value: 1.14e-05
|
|||||||||||||||
| cbiO | PRK13648 | cobalt transporter ATP-binding subunit; Provisional |
639-702 | 1.62e-05 | |||||||||||
cobalt transporter ATP-binding subunit; Provisional Pssm-ID: 184207 [Multi-domain] Cd Length: 269 Bit Score: 47.44 E-value: 1.62e-05
|
|||||||||||||||
| MRP_assoc_pro | TIGR00957 | multi drug resistance-associated protein (MRP); This model describes multi drug ... |
507-769 | 1.65e-05 | |||||||||||
multi drug resistance-associated protein (MRP); This model describes multi drug resistance-associated protein (MRP) in eukaryotes. The multidrug resistance-associated protein is an integral membrane protein that causes multidrug resistance when overexpressed in mammalian cells. It belongs to ABC transporter superfamily. The protein topology and function was experimentally demonstrated by epitope tagging and immunofluorescence. Insertion of tags in the critical regions associated with drug efflux, abrogated its function. The C-terminal domain seem to highly conserved. [Transport and binding proteins, Other] Pssm-ID: 188098 [Multi-domain] Cd Length: 1522 Bit Score: 48.79 E-value: 1.65e-05
|
|||||||||||||||
| cbiO | PRK13635 | energy-coupling factor ABC transporter ATP-binding protein; |
640-706 | 1.80e-05 | |||||||||||
energy-coupling factor ABC transporter ATP-binding protein; Pssm-ID: 184195 [Multi-domain] Cd Length: 279 Bit Score: 47.32 E-value: 1.80e-05
|
|||||||||||||||
| cbiO | PRK13647 | cobalt transporter ATP-binding subunit; Provisional |
642-719 | 2.07e-05 | |||||||||||
cobalt transporter ATP-binding subunit; Provisional Pssm-ID: 237457 [Multi-domain] Cd Length: 274 Bit Score: 47.04 E-value: 2.07e-05
|
|||||||||||||||
| fecE | PRK11231 | Fe(3+) dicitrate ABC transporter ATP-binding protein FecE; |
656-714 | 2.34e-05 | |||||||||||
Fe(3+) dicitrate ABC transporter ATP-binding protein FecE; Pssm-ID: 183044 [Multi-domain] Cd Length: 255 Bit Score: 46.55 E-value: 2.34e-05
|
|||||||||||||||
| ABC2_perm_RbbA | NF033858 | ribosome-associated ATPase/putative transporter RbbA; |
661-734 | 5.29e-05 | |||||||||||
ribosome-associated ATPase/putative transporter RbbA; Pssm-ID: 468210 [Multi-domain] Cd Length: 907 Bit Score: 47.04 E-value: 5.29e-05
|
|||||||||||||||
| 3a01203 | TIGR00954 | Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protein; [Transport and binding proteins, ... |
661-728 | 5.79e-05 | |||||||||||
Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids] Pssm-ID: 273360 [Multi-domain] Cd Length: 659 Bit Score: 46.67 E-value: 5.79e-05
|
|||||||||||||||
| ABCG_White | cd03234 | White pigment protein homolog of ABCG transporter subfamily; The White subfamily represents ... |
661-758 | 7.56e-05 | |||||||||||
White pigment protein homolog of ABCG transporter subfamily; The White subfamily represents ABC transporters homologous to the Drosophila white gene, which acts as a dimeric importer for eye pigment precursors. The eye pigmentation of Drosophila is developed from the synthesis and deposition in the cells of red pigments, which are synthesized from guanine, and brown pigments, which are synthesized from tryptophan. The pigment precursors are encoded by the white, brown, and scarlet genes, respectively. Evidence from genetic and biochemical studies suggest that the White and Brown proteins function as heterodimers to import guanine, while the White and Scarlet proteins function to import tryptophan. However, a recent study also suggests that White may be involved in the transport of a metabolite, such as 3-hydroxykynurenine, across intracellular membranes. Mammalian ABC transporters belonging to the White subfamily (ABCG1, ABCG5, and ABCG8) have been shown to be involved in the regulation of lipid-trafficking mechanisms in macrophages, hepatocytes, and intestinal mucosa cells. ABCG1 (ABC8), the human homolog of the Drosophila white gene is induced in monocyte-derived macrophages during cholesterol influx mediated by acetylated low-density lipoprotein. It is possible that human ABCG1 forms heterodimers with several heterologous partners. Pssm-ID: 213201 [Multi-domain] Cd Length: 226 Bit Score: 44.95 E-value: 7.56e-05
|
|||||||||||||||
| PLN03130 | PLN03130 | ABC transporter C family member; Provisional |
564-706 | 7.75e-05 | |||||||||||
ABC transporter C family member; Provisional Pssm-ID: 215595 [Multi-domain] Cd Length: 1622 Bit Score: 46.65 E-value: 7.75e-05
|
|||||||||||||||
| ABCG_PDR_domain1 | cd03233 | First domain of the pleiotropic drug resistance-like subfamily G of ATP-binding cassette ... |
647-714 | 1.33e-04 | |||||||||||
First domain of the pleiotropic drug resistance-like subfamily G of ATP-binding cassette transporters; The pleiotropic drug resistance (PDR) is a well-described phenomenon occurring in fungi and shares several similarities with processes in bacteria and higher eukaryotes. This PDR subfamily represents domain I of its (ABC-IM)2 organization. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and more complex organic molecules. The nucleotide-binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213200 [Multi-domain] Cd Length: 202 Bit Score: 43.79 E-value: 1.33e-04
|
|||||||||||||||
| ABC_FtsE | cd03292 | Cell division ATP-binding protein FtsE; The FtsEX complex resembles an ABC transporter, where ... |
659-706 | 1.39e-04 | |||||||||||
Cell division ATP-binding protein FtsE; The FtsEX complex resembles an ABC transporter, where FtsE is the ATPase and the membrane subunit FtsX resembles a permease subunit. But rather than transporting any substrate, the complex acts in cell division by undergoing conformational changes that alter the activity of cell wall hydrolases located outside the plasma membrane. The complex is widely conserved in bacteria, but also extremely divergent in sequence between different lineages Pssm-ID: 213259 [Multi-domain] Cd Length: 214 Bit Score: 43.94 E-value: 1.39e-04
|
|||||||||||||||
| PRK13651 | PRK13651 | cobalt transporter ATP-binding subunit; Provisional |
644-692 | 1.90e-04 | |||||||||||
cobalt transporter ATP-binding subunit; Provisional Pssm-ID: 184210 [Multi-domain] Cd Length: 305 Bit Score: 44.31 E-value: 1.90e-04
|
|||||||||||||||
| PRK14267 | PRK14267 | phosphate ABC transporter ATP-binding protein; Provisional |
656-713 | 2.51e-04 | |||||||||||
phosphate ABC transporter ATP-binding protein; Provisional Pssm-ID: 184596 [Multi-domain] Cd Length: 253 Bit Score: 43.68 E-value: 2.51e-04
|
|||||||||||||||
| PRK15079 | PRK15079 | oligopeptide ABC transporter ATP-binding protein OppF; Provisional |
643-706 | 3.60e-04 | |||||||||||
oligopeptide ABC transporter ATP-binding protein OppF; Provisional Pssm-ID: 185037 [Multi-domain] Cd Length: 331 Bit Score: 43.54 E-value: 3.60e-04
|
|||||||||||||||
| MK0520 | COG2401 | ABC-type ATPase fused to a predicted acetyltransferase domain [General function prediction ... |
655-726 | 4.24e-04 | |||||||||||
ABC-type ATPase fused to a predicted acetyltransferase domain [General function prediction only]; Pssm-ID: 441957 [Multi-domain] Cd Length: 222 Bit Score: 42.64 E-value: 4.24e-04
|
|||||||||||||||
| ABC_CcmA_heme_exporter | cd03231 | Cytochrome c biogenesis ATP-binding export protein; CcmA, the ATP-binding component of the ... |
652-732 | 4.64e-04 | |||||||||||
Cytochrome c biogenesis ATP-binding export protein; CcmA, the ATP-binding component of the bacterial CcmAB transporter. The CCM family is involved in bacterial cytochrome c biogenesis. Cytochrome c maturation in E. coli requires the ccm operon, which encodes eight membrane proteins (CcmABCDEFGH). CcmE is a periplasmic heme chaperon that binds heme covalently and transfers it onto apocytochrome c in the presence of CcmF, CcmG, and CcmH. The CcmAB proteins represent an ABC transporter and the CcmCD proteins participate in heme transfer to CcmE. Pssm-ID: 213198 [Multi-domain] Cd Length: 201 Bit Score: 42.09 E-value: 4.64e-04
|
|||||||||||||||
| PRK13539 | PRK13539 | cytochrome c biogenesis protein CcmA; Provisional |
654-757 | 5.08e-04 | |||||||||||
cytochrome c biogenesis protein CcmA; Provisional Pssm-ID: 237421 [Multi-domain] Cd Length: 207 Bit Score: 42.17 E-value: 5.08e-04
|
|||||||||||||||
| cbiO | PRK13634 | cobalt transporter ATP-binding subunit; Provisional |
644-704 | 7.53e-04 | |||||||||||
cobalt transporter ATP-binding subunit; Provisional Pssm-ID: 237454 [Multi-domain] Cd Length: 290 Bit Score: 42.31 E-value: 7.53e-04
|
|||||||||||||||
| PRK10636 | PRK10636 | putative ABC transporter ATP-binding protein; Provisional |
655-714 | 8.65e-04 | |||||||||||
putative ABC transporter ATP-binding protein; Provisional Pssm-ID: 236729 [Multi-domain] Cd Length: 638 Bit Score: 42.85 E-value: 8.65e-04
|
|||||||||||||||
| cbiO | PRK13641 | energy-coupling factor transporter ATPase; |
643-706 | 9.27e-04 | |||||||||||
energy-coupling factor transporter ATPase; Pssm-ID: 237456 [Multi-domain] Cd Length: 287 Bit Score: 42.12 E-value: 9.27e-04
|
|||||||||||||||
| ModF | COG1119 | ABC-type molybdenum transport system, ATPase component ModF/photorepair protein PhrA ... |
644-704 | 9.40e-04 | |||||||||||
ABC-type molybdenum transport system, ATPase component ModF/photorepair protein PhrA [Inorganic ion transport and metabolism]; Pssm-ID: 440736 [Multi-domain] Cd Length: 250 Bit Score: 41.61 E-value: 9.40e-04
|
|||||||||||||||
| ugpC | PRK11650 | sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC; |
643-688 | 1.01e-03 | |||||||||||
sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC; Pssm-ID: 236947 [Multi-domain] Cd Length: 356 Bit Score: 42.14 E-value: 1.01e-03
|
|||||||||||||||
| YejF | COG4172 | ABC-type microcin C transport system, duplicated ATPase component YejF [Secondary metabolites ... |
661-706 | 1.18e-03 | |||||||||||
ABC-type microcin C transport system, duplicated ATPase component YejF [Secondary metabolites biosynthesis, transport and catabolism]; Pssm-ID: 443332 [Multi-domain] Cd Length: 533 Bit Score: 42.36 E-value: 1.18e-03
|
|||||||||||||||
| AbcC | COG1135 | ABC-type methionine transport system, ATPase component [Amino acid transport and metabolism]; |
644-688 | 1.28e-03 | |||||||||||
ABC-type methionine transport system, ATPase component [Amino acid transport and metabolism]; Pssm-ID: 440750 [Multi-domain] Cd Length: 339 Bit Score: 41.60 E-value: 1.28e-03
|
|||||||||||||||
| dppF | PRK11308 | dipeptide transporter ATP-binding subunit; Provisional |
661-687 | 1.29e-03 | |||||||||||
dipeptide transporter ATP-binding subunit; Provisional Pssm-ID: 236898 [Multi-domain] Cd Length: 327 Bit Score: 41.87 E-value: 1.29e-03
|
|||||||||||||||
| PRK15064 | PRK15064 | ABC transporter ATP-binding protein; Provisional |
609-713 | 1.81e-03 | |||||||||||
ABC transporter ATP-binding protein; Provisional Pssm-ID: 237894 [Multi-domain] Cd Length: 530 Bit Score: 41.80 E-value: 1.81e-03
|
|||||||||||||||
| cbiO | PRK13650 | energy-coupling factor transporter ATPase; |
642-693 | 1.90e-03 | |||||||||||
energy-coupling factor transporter ATPase; Pssm-ID: 184209 [Multi-domain] Cd Length: 279 Bit Score: 40.87 E-value: 1.90e-03
|
|||||||||||||||
| ABC_UvrA | cd03238 | ATP-binding cassette domain of the excision repair protein UvrA; Nucleotide excision repair in ... |
661-694 | 1.96e-03 | |||||||||||
ATP-binding cassette domain of the excision repair protein UvrA; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep ATP-dependent reaction that requires the UvrA, UvrB, and UvrC proteins. Both UvrA and UvrB are ATPases, with UvrA having two ATP binding sites, which have the characteristic signature of the family of ABC proteins, and UvrB having one ATP binding site that is structurally related to that of helicases. Pssm-ID: 213205 [Multi-domain] Cd Length: 176 Bit Score: 40.00 E-value: 1.96e-03
|
|||||||||||||||
| cbiO | PRK13642 | energy-coupling factor transporter ATPase; |
644-706 | 2.54e-03 | |||||||||||
energy-coupling factor transporter ATPase; Pssm-ID: 184202 [Multi-domain] Cd Length: 277 Bit Score: 40.46 E-value: 2.54e-03
|
|||||||||||||||
| tagH | PRK13545 | teichoic acids export protein ATP-binding subunit; Provisional |
661-711 | 2.66e-03 | |||||||||||
teichoic acids export protein ATP-binding subunit; Provisional Pssm-ID: 184130 [Multi-domain] Cd Length: 549 Bit Score: 41.03 E-value: 2.66e-03
|
|||||||||||||||
| PRK15439 | PRK15439 | autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional |
659-747 | 2.80e-03 | |||||||||||
autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional Pssm-ID: 185336 [Multi-domain] Cd Length: 510 Bit Score: 41.19 E-value: 2.80e-03
|
|||||||||||||||
| PRK10247 | PRK10247 | putative ABC transporter ATP-binding protein YbbL; Provisional |
656-728 | 3.53e-03 | |||||||||||
putative ABC transporter ATP-binding protein YbbL; Provisional Pssm-ID: 182331 [Multi-domain] Cd Length: 225 Bit Score: 39.70 E-value: 3.53e-03
|
|||||||||||||||
| PRK14247 | PRK14247 | phosphate ABC transporter ATP-binding protein; Provisional |
642-706 | 4.20e-03 | |||||||||||
phosphate ABC transporter ATP-binding protein; Provisional Pssm-ID: 172735 [Multi-domain] Cd Length: 250 Bit Score: 39.90 E-value: 4.20e-03
|
|||||||||||||||
| ABC_FeS_Assembly | cd03217 | ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Biosynthesis of ... |
661-706 | 4.61e-03 | |||||||||||
ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Biosynthesis of iron-sulfur clusters (Fe-S) depends on multi-protein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under stressful conditions. The SUF system is made of six proteins: SufC is an atypical cytoplasmic ABC-ATPase, which forms a complex with SufB and SufD; SufA plays the role of a scaffold protein for assembly of iron-sulfur clusters and delivery to target proteins; SufS is a cysteine desulfurase which mobilizes the sulfur atom from cysteine and provides it to the cluster; SufE has no associated function yet. Pssm-ID: 213184 [Multi-domain] Cd Length: 200 Bit Score: 39.05 E-value: 4.61e-03
|
|||||||||||||||
| ABCD_peroxisomal_ALDP | cd03223 | ATP-binding cassette domain of peroxisomal transporter, subfamily D; Peroxisomal ATP-binding ... |
644-728 | 6.22e-03 | |||||||||||
ATP-binding cassette domain of peroxisomal transporter, subfamily D; Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome. The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed during fatty acid beta-oxidation. To communicate with the cytoplasm and mitochondria, peroxisomes need dedicated proteins to transport such hydrophilic molecules across their membranes. X-linked adrenoleukodystrophy (X-ALD) is caused by mutations in the ALD gene, which encodes ALDP (adrenoleukodystrophy protein ), a peroxisomal integral membrane protein that is a member of the ATP-binding cassette (ABC) transporter protein family. The disease is characterized by a striking and unpredictable variation in phenotypic expression. Phenotypes include the rapidly progressive childhood cerebral form (CCALD), the milder adult form, adrenomyeloneuropathy (AMN), and variants without neurologic involvement (i.e. asymptomatic). Pssm-ID: 213190 [Multi-domain] Cd Length: 166 Bit Score: 38.29 E-value: 6.22e-03
|
|||||||||||||||
| PRK13538 | PRK13538 | cytochrome c biogenesis heme-transporting ATPase CcmA; |
655-730 | 6.25e-03 | |||||||||||
cytochrome c biogenesis heme-transporting ATPase CcmA; Pssm-ID: 184125 [Multi-domain] Cd Length: 204 Bit Score: 38.63 E-value: 6.25e-03
|
|||||||||||||||
| ABC_6TM_TmrB_like | cd18541 | Six-transmembrane helical domain (TmrB) of the heterodimeric Thermus thermophilus multidrug ... |
344-617 | 7.75e-03 | |||||||||||
Six-transmembrane helical domain (TmrB) of the heterodimeric Thermus thermophilus multidrug resistance proteins TmrAB, and similar proteins; This group represents the six-transmembrane helical domain (6-TMD) of the heterodimeric Thermus thermophilus multidrug resistance proteins A and B (TmrAB), a homolog of the Antigen Translocation Complex Tap, and similar proteins. TmrAB has been shown to able to restore antigen processing in human TAP-deficient cells. The 6-transmembrane (TM) helices typically found in the ATP-binding cassette (ABC) transporters that function as exporters, which contain 6 TM helices per subunit (domain), or a total of 12 TM helices for the complete transporter. The ABC exporters are found in both prokaryotes and eukaryotes, where they mediate the cellular secretion of toxic compounds and a various type of lipids. ABC transporters typically consist of two transmembrane domains (TMDs) and two nucleotide-binding domains (NBDs). The sequences and structures of the TMDs are quite varied between the different type of transporters, suggesting significant structural diversity of the translocated substrates, while NBDs are conserved among all ABC transporters. The two NBDs together bind and hydrolyze ATP, thereby providing the driving force for transport, while the TMDs participate in substrate recognition and translocation across the lipid membrane. However, some ABC genes are organized as half-transporters, which must form either homodimers or heterodimers to form a functional transporter. The ABC exporters play a role in multidrug resistance to antibiotics and anticancer agents, and mutations in these proteins have been shown to cause severe human diseases such as cystic fibrosis. Pssm-ID: 349985 [Multi-domain] Cd Length: 293 Bit Score: 38.93 E-value: 7.75e-03
|
|||||||||||||||
| lolD | PRK11629 | lipoprotein-releasing ABC transporter ATP-binding protein LolD; |
661-706 | 8.53e-03 | |||||||||||
lipoprotein-releasing ABC transporter ATP-binding protein LolD; Pssm-ID: 183244 [Multi-domain] Cd Length: 233 Bit Score: 38.64 E-value: 8.53e-03
|
|||||||||||||||
| uvrA | PRK00349 | excinuclease ABC subunit UvrA; |
632-688 | 9.89e-03 | |||||||||||
excinuclease ABC subunit UvrA; Pssm-ID: 234734 [Multi-domain] Cd Length: 943 Bit Score: 39.29 E-value: 9.89e-03
|
|||||||||||||||
| Blast search parameters | ||||
|
