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Conserved domains on  [gi|1039768452|ref|XP_017175848|]
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tRNA dimethylallyltransferase isoform X2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IPPT pfam01715
IPP transferase; This is a family of IPP transferases EC:2.5.1.8 also known as tRNA delta(2) ...
 7-105 1.14e-22

IPP transferase; This is a family of IPP transferases EC:2.5.1.8 also known as tRNA delta(2)-isopentenylpyrophosphate transferase. These enzymes modify both cytoplasmic and mitochondrial tRNAs at A(37) to give isopentenyl A(37).


:

Pssm-ID: 460304  Cd Length: 242  Bit Score: 92.49  E-value: 1.14e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768452   7 PVLDERLDKRVDDMLAAGLLEELRGFHRRYnlknisensQDYQHGIFQSIGFKEFHEYLttEGKCTpetsnqlLKKGIEA 86
Cdd:pfam01715 162 EELYERINARVDAMLEAGLLEEVRALLDRG---------YGGDLPAMQAIGYKELLAYL--DGEIS-------LEEAIEL 223

                          90
                  ....*....|....*....
gi 1039768452  87 LKQVTKRYARKQNRWVKNR 105
Cdd:pfam01715 224 IKRATRQYAKRQLTWFRRD 242
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 168-192 1.47e-03

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


:

Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 35.22  E-value: 1.47e-03
                          10        20
                  ....*....|....*....|....*
gi 1039768452 168 HMCDLCDRIIIGDREWAAHLKSKSH 192
Cdd:pfam12171   2 FYCVLCDKYFKSENALQNHLKSKKH 26
 
Name Accession Description Interval E-value
IPPT pfam01715
IPP transferase; This is a family of IPP transferases EC:2.5.1.8 also known as tRNA delta(2) ...
 7-105 1.14e-22

IPP transferase; This is a family of IPP transferases EC:2.5.1.8 also known as tRNA delta(2)-isopentenylpyrophosphate transferase. These enzymes modify both cytoplasmic and mitochondrial tRNAs at A(37) to give isopentenyl A(37).


Pssm-ID: 460304  Cd Length: 242  Bit Score: 92.49  E-value: 1.14e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768452   7 PVLDERLDKRVDDMLAAGLLEELRGFHRRYnlknisensQDYQHGIFQSIGFKEFHEYLttEGKCTpetsnqlLKKGIEA 86
Cdd:pfam01715 162 EELYERINARVDAMLEAGLLEEVRALLDRG---------YGGDLPAMQAIGYKELLAYL--DGEIS-------LEEAIEL 223

                          90
                  ....*....|....*....
gi 1039768452  87 LKQVTKRYARKQNRWVKNR 105
Cdd:pfam01715 224 IKRATRQYAKRQLTWFRRD 242
PLN02748 PLN02748
tRNA dimethylallyltransferase
 3-192 1.94e-15

tRNA dimethylallyltransferase


Pssm-ID: 215399 [Multi-domain]  Cd Length: 468  Bit Score: 74.92  E-value: 1.94e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768452   3 NAKWPVLDERLDKRVDDMLAAGLLEElrgfhrrynLKNISENSQDYQHGIFQSIGFKEFHEYL------TTEGKCTPETS 76
Cdd:PLN02748  234 DADTAVLDRYVNQRVDCMIDAGLLDE---------VYDIYDPGADYTRGLRQAIGVREFEDFLrlylsrNENGELTSSSN 304

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768452  77 NQ---------------------LLKKGIEALKQVTKRYARKQNRWVkNRFLSRPGPSVPPV----YGLEVSDVSkWEES 131
Cdd:PLN02748  305 NDkvmkensrkilnfphddklkiLLDEAIDQVKLNTRRLVRRQKRRL-HRLNTVFGWNIHYIdateAILCKSEES-WNAK 382

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039768452 132 VLEPALNIVQSFIQGHKPTAMPVKMAYNESENKRSYHMCDLCD-RIIIGDREWAAHLKSKSH 192
Cdd:PLN02748  383 VVKPAVEIVRRFLSDDTSSGPDASSGKSVSRELWTQYVCEACGnKVLRGAHEWEQHKQGRGH 444
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 168-192 1.47e-03

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 35.22  E-value: 1.47e-03
                          10        20
                  ....*....|....*....|....*
gi 1039768452 168 HMCDLCDRIIIGDREWAAHLKSKSH 192
Cdd:pfam12171   2 FYCVLCDKYFKSENALQNHLKSKKH 26
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 168-199 2.55e-03

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 34.54  E-value: 2.55e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1039768452  168 HMCDLCDRIIIGDREWAAHLKSKSHLHQLKKR 199
Cdd:smart00451   4 FYCKLCNVTFTDEISVEAHLKGKKHKKNVKKR 35
 
Name Accession Description Interval E-value
IPPT pfam01715
IPP transferase; This is a family of IPP transferases EC:2.5.1.8 also known as tRNA delta(2) ...
 7-105 1.14e-22

IPP transferase; This is a family of IPP transferases EC:2.5.1.8 also known as tRNA delta(2)-isopentenylpyrophosphate transferase. These enzymes modify both cytoplasmic and mitochondrial tRNAs at A(37) to give isopentenyl A(37).


Pssm-ID: 460304  Cd Length: 242  Bit Score: 92.49  E-value: 1.14e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768452   7 PVLDERLDKRVDDMLAAGLLEELRGFHRRYnlknisensQDYQHGIFQSIGFKEFHEYLttEGKCTpetsnqlLKKGIEA 86
Cdd:pfam01715 162 EELYERINARVDAMLEAGLLEEVRALLDRG---------YGGDLPAMQAIGYKELLAYL--DGEIS-------LEEAIEL 223

                          90
                  ....*....|....*....
gi 1039768452  87 LKQVTKRYARKQNRWVKNR 105
Cdd:pfam01715 224 IKRATRQYAKRQLTWFRRD 242
PLN02748 PLN02748
tRNA dimethylallyltransferase
 3-192 1.94e-15

tRNA dimethylallyltransferase


Pssm-ID: 215399 [Multi-domain]  Cd Length: 468  Bit Score: 74.92  E-value: 1.94e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768452   3 NAKWPVLDERLDKRVDDMLAAGLLEElrgfhrrynLKNISENSQDYQHGIFQSIGFKEFHEYL------TTEGKCTPETS 76
Cdd:PLN02748  234 DADTAVLDRYVNQRVDCMIDAGLLDE---------VYDIYDPGADYTRGLRQAIGVREFEDFLrlylsrNENGELTSSSN 304

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768452  77 NQ---------------------LLKKGIEALKQVTKRYARKQNRWVkNRFLSRPGPSVPPV----YGLEVSDVSkWEES 131
Cdd:PLN02748  305 NDkvmkensrkilnfphddklkiLLDEAIDQVKLNTRRLVRRQKRRL-HRLNTVFGWNIHYIdateAILCKSEES-WNAK 382

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039768452 132 VLEPALNIVQSFIQGHKPTAMPVKMAYNESENKRSYHMCDLCD-RIIIGDREWAAHLKSKSH 192
Cdd:PLN02748  383 VVKPAVEIVRRFLSDDTSSGPDASSGKSVSRELWTQYVCEACGnKVLRGAHEWEQHKQGRGH 444
PLN02165 PLN02165
adenylate isopentenyltransferase
 7-144 2.09e-10

adenylate isopentenyltransferase


Pssm-ID: 177823  Cd Length: 334  Bit Score: 59.45  E-value: 2.09e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768452   7 PVLDERLDKRVDDMLAAGLLEELRGFHRrynlkniSENSQDYQHGIFQSIGFKEFHEYLTtegKCTPETS----NQLLK- 81
Cdd:PLN02165  186 PVLFEYLSKRVDEMMDSGMFEELAEFYD-------PVKSGSEPLGIRKAIGVPEFDRYFK---KYPPENKmgkwDQARKa 255

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039768452  82 ---KGIEALKQVTKRYARKQNR---------WVKNRFLSRPG-PSVPPVYGLEVSDVSKWEESVLEPALNIVQSFI 144
Cdd:PLN02165  256 ayeEAVREIKENTCQLAKRQIEkimklksagWDIKRVDATASfRAVMRKKGKKKKWREIWEKDVLEPSVKIVKRFL 331
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 168-192 1.47e-03

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 35.22  E-value: 1.47e-03
                          10        20
                  ....*....|....*....|....*
gi 1039768452 168 HMCDLCDRIIIGDREWAAHLKSKSH 192
Cdd:pfam12171   2 FYCVLCDKYFKSENALQNHLKSKKH 26
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 168-199 2.55e-03

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 34.54  E-value: 2.55e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1039768452  168 HMCDLCDRIIIGDREWAAHLKSKSHLHQLKKR 199
Cdd:smart00451   4 FYCKLCNVTFTDEISVEAHLKGKKHKKNVKKR 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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