leucine-rich repeat-containing G-protein coupled receptor 6 isoform X3 [Mus musculus]
List of domain hits
Name | Accession | Description | Interval | E-value | ||||||
7tmA_LGR6 | cd15362 | leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane ... |
562-838 | 1.90e-158 | ||||||
leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane GPCRs; The leucine-rich repeat containing G-protein coupled receptor LGR5, together with its family members LGR4 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR5 serves as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 is a marker for multipotent stem cells in the hair follicle that generate all skin cell lineages. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins. : Pssm-ID: 320484 Cd Length: 276 Bit Score: 464.65 E-value: 1.90e-158
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
100-465 | 3.13e-33 | ||||||
Leucine-rich repeat (LRR) protein [Transcription]; : Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 133.14 E-value: 3.13e-33
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LRR_8 | pfam13855 | Leucine rich repeat; |
70-126 | 5.22e-11 | ||||||
Leucine rich repeat; : Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 58.69 E-value: 5.22e-11
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LRRNT | smart00013 | Leucine rich repeat N-terminal domain; |
34-68 | 3.00e-03 | ||||||
Leucine rich repeat N-terminal domain; : Pssm-ID: 214470 [Multi-domain] Cd Length: 33 Bit Score: 36.14 E-value: 3.00e-03
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Name | Accession | Description | Interval | E-value | |||||||
7tmA_LGR6 | cd15362 | leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane ... |
562-838 | 1.90e-158 | |||||||
leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane GPCRs; The leucine-rich repeat containing G-protein coupled receptor LGR5, together with its family members LGR4 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR5 serves as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 is a marker for multipotent stem cells in the hair follicle that generate all skin cell lineages. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins. Pssm-ID: 320484 Cd Length: 276 Bit Score: 464.65 E-value: 1.90e-158
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
100-465 | 3.13e-33 | |||||||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 133.14 E-value: 3.13e-33
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PLN00113 | PLN00113 | leucine-rich repeat receptor-like protein kinase; Provisional |
60-435 | 8.60e-26 | |||||||
leucine-rich repeat receptor-like protein kinase; Provisional Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 114.56 E-value: 8.60e-26
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PPP1R42 | cd21340 | protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
73-286 | 6.95e-16 | |||||||
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation. Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 77.52 E-value: 6.95e-16
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LRR_8 | pfam13855 | Leucine rich repeat; |
92-150 | 1.15e-13 | |||||||
Leucine rich repeat; Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 66.39 E-value: 1.15e-13
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LRR_8 | pfam13855 | Leucine rich repeat; |
70-126 | 5.22e-11 | |||||||
Leucine rich repeat; Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 58.69 E-value: 5.22e-11
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LRRNT | smart00013 | Leucine rich repeat N-terminal domain; |
34-68 | 3.00e-03 | |||||||
Leucine rich repeat N-terminal domain; Pssm-ID: 214470 [Multi-domain] Cd Length: 33 Bit Score: 36.14 E-value: 3.00e-03
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Name | Accession | Description | Interval | E-value | |||||||
7tmA_LGR6 | cd15362 | leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane ... |
562-838 | 1.90e-158 | |||||||
leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane GPCRs; The leucine-rich repeat containing G-protein coupled receptor LGR5, together with its family members LGR4 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR5 serves as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 is a marker for multipotent stem cells in the hair follicle that generate all skin cell lineages. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins. Pssm-ID: 320484 Cd Length: 276 Bit Score: 464.65 E-value: 1.90e-158
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7tmA_LRR_GPR | cd15138 | orphan leucine-rich repeat-containing G protein-coupled receptors, member of the class A ... |
562-838 | 7.08e-139 | |||||||
orphan leucine-rich repeat-containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes leucine-rich repeat-containing G-protein coupled receptor 4 (LGR4), 5 (LGR5), and 6 (LGR6). These receptors contain a subfamily of receptors related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The RSPO proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. LGR5 acts as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 also serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins. Pssm-ID: 320266 Cd Length: 274 Bit Score: 414.25 E-value: 7.08e-139
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7tmA_LGR5 | cd15363 | leucine-rich repeats-containing G protein-coupled receptor 5, member of the class A family of ... |
562-838 | 3.36e-96 | |||||||
leucine-rich repeats-containing G protein-coupled receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The leucine-rich repeat containing G-protein coupled receptor LGR6, together with its family members LGR4 and LGR5, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR6 serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages, whereas LGR5 is a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins. Pssm-ID: 320485 Cd Length: 274 Bit Score: 302.92 E-value: 3.36e-96
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7tmA_LGR4 | cd15361 | leucine-rich repeats-containing G protein-coupled receptor 4, member of the class A family of ... |
562-837 | 1.21e-75 | |||||||
leucine-rich repeats-containing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The leucine-rich repeat containing G-protein coupled receptor Lgr4 (formerly known as Gpr48), together with its close family members LGR5 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. LGR5 acts as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 also serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins. Pssm-ID: 320483 Cd Length: 274 Bit Score: 248.24 E-value: 1.21e-75
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7tmA_Glycoprotein_LRR_R-like | cd14980 | glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ... |
562-838 | 1.94e-40 | |||||||
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones. Pssm-ID: 320111 [Multi-domain] Cd Length: 286 Bit Score: 150.85 E-value: 1.94e-40
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7tmA_Glyco_hormone_R | cd15136 | glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ... |
562-838 | 1.18e-37 | |||||||
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Pssm-ID: 320264 [Multi-domain] Cd Length: 275 Bit Score: 142.35 E-value: 1.18e-37
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
100-465 | 3.13e-33 | |||||||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 133.14 E-value: 3.13e-33
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
112-456 | 2.87e-32 | |||||||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 130.44 E-value: 2.87e-32
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
63-446 | 6.22e-31 | |||||||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 126.59 E-value: 6.22e-31
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7tmA_TSH-R | cd15964 | thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family ... |
564-838 | 1.87e-26 | |||||||
thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. TSH-R plays an important role thyroid physiology, and its activation stimulates the production of thyroxine (T4) and triiodothyronine (T3). Defects in TSH-R are a cause of several types of hyperthyroidism. The receptor is predominantly found on the surface of the thyroid epithelial cells and couples to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production. TSH and cAMP stimulate thyroid cell proliferation, differentiation, and function. Pssm-ID: 320630 [Multi-domain] Cd Length: 275 Bit Score: 109.99 E-value: 1.87e-26
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PLN00113 | PLN00113 | leucine-rich repeat receptor-like protein kinase; Provisional |
60-435 | 8.60e-26 | |||||||
leucine-rich repeat receptor-like protein kinase; Provisional Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 114.56 E-value: 8.60e-26
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
208-471 | 5.18e-25 | |||||||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 108.87 E-value: 5.18e-25
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7tmA_FSH-R | cd15360 | follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G ... |
564-838 | 1.39e-23 | |||||||
follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. FSH-R functions in gonad development and is found in the ovary, testis, and uterus. Defects in this receptor cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. The FSH-R activation couples to the G(s)-protein and stimulates adenylate cyclase, thereby promoting cAMP production. Pssm-ID: 320482 Cd Length: 275 Bit Score: 101.47 E-value: 1.39e-23
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
51-313 | 1.86e-23 | |||||||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 104.25 E-value: 1.86e-23
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7tmA_LHCGR | cd15359 | luteinizing hormone-choriogonadotropin receptor, member of the class A family of ... |
564-838 | 8.45e-22 | |||||||
luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. LHCGR is expressed predominantly in the ovary and testis, and plays an essential role in sexual development and reproductive processes. LHCGR couples primarily to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production. Pssm-ID: 320481 [Multi-domain] Cd Length: 275 Bit Score: 96.47 E-value: 8.45e-22
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7tmA_Relaxin_R | cd15137 | relaxin family peptide receptors, member of the class A family of seven-transmembrane G ... |
564-836 | 3.49e-19 | |||||||
relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP. Pssm-ID: 320265 [Multi-domain] Cd Length: 284 Bit Score: 88.80 E-value: 3.49e-19
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PPP1R42 | cd21340 | protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
73-286 | 6.95e-16 | |||||||
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation. Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 77.52 E-value: 6.95e-16
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LRR_8 | pfam13855 | Leucine rich repeat; |
92-150 | 1.15e-13 | |||||||
Leucine rich repeat; Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 66.39 E-value: 1.15e-13
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PPP1R42 | cd21340 | protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
161-438 | 3.92e-13 | |||||||
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation. Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 69.43 E-value: 3.92e-13
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PPP1R42 | cd21340 | protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
304-453 | 5.06e-13 | |||||||
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation. Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 69.04 E-value: 5.06e-13
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LRR_8 | pfam13855 | Leucine rich repeat; |
374-434 | 6.88e-13 | |||||||
Leucine rich repeat; Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 64.08 E-value: 6.88e-13
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LRR_8 | pfam13855 | Leucine rich repeat; |
186-246 | 7.30e-13 | |||||||
Leucine rich repeat; Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 64.08 E-value: 7.30e-13
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PPP1R42 | cd21340 | protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
156-336 | 4.88e-12 | |||||||
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation. Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 66.35 E-value: 4.88e-12
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7tmA_RXFP2_LGR8 | cd15966 | relaxin receptor 2 (or LGR8), member of the class A family of seven-transmembrane G ... |
564-838 | 2.05e-11 | |||||||
relaxin receptor 2 (or LGR8), member of the class A family of seven-transmembrane G protein-coupled receptors; Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural similarity, but low sequence similarity, and exert their physiological functions by activating a group of four G protein-coupled receptors, RXFP1-4. INSL3 is the endogenous ligand for RXFP2, which couples to the G(s) protein to increase intracellular cAMP levels, but also to the GoB protein to decrease cAMP formation. RXFP2 (or LGR8) is expressed in various tissues including the brain, kidney, muscle, testis, thyroid, uterus, and peripheral blood cells, among others. Pssm-ID: 320632 Cd Length: 287 Bit Score: 65.58 E-value: 2.05e-11
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PLN00113 | PLN00113 | leucine-rich repeat receptor-like protein kinase; Provisional |
60-262 | 2.64e-11 | |||||||
leucine-rich repeat receptor-like protein kinase; Provisional Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 67.57 E-value: 2.64e-11
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LRR_8 | pfam13855 | Leucine rich repeat; |
70-126 | 5.22e-11 | |||||||
Leucine rich repeat; Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 58.69 E-value: 5.22e-11
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LRR_8 | pfam13855 | Leucine rich repeat; |
210-269 | 4.40e-10 | |||||||
Leucine rich repeat; Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 55.99 E-value: 4.40e-10
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LRR_8 | pfam13855 | Leucine rich repeat; |
162-222 | 5.40e-10 | |||||||
Leucine rich repeat; Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 55.99 E-value: 5.40e-10
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PRK15370 | PRK15370 | type III secretion system effector E3 ubiquitin transferase SlrP; |
55-291 | 8.44e-10 | |||||||
type III secretion system effector E3 ubiquitin transferase SlrP; Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 62.79 E-value: 8.44e-10
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LRR_8 | pfam13855 | Leucine rich repeat; |
352-410 | 1.65e-09 | |||||||
Leucine rich repeat; Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 54.45 E-value: 1.65e-09
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PRK15370 | PRK15370 | type III secretion system effector E3 ubiquitin transferase SlrP; |
57-250 | 1.90e-09 | |||||||
type III secretion system effector E3 ubiquitin transferase SlrP; Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 61.64 E-value: 1.90e-09
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LRR_8 | pfam13855 | Leucine rich repeat; |
138-198 | 6.48e-09 | |||||||
Leucine rich repeat; Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 52.91 E-value: 6.48e-09
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LRR_5 | pfam13306 | BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ... |
201-320 | 3.06e-08 | |||||||
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis. Pssm-ID: 463839 [Multi-domain] Cd Length: 127 Bit Score: 52.93 E-value: 3.06e-08
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7tmA_RXFP1_LGR7 | cd15965 | relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G ... |
607-836 | 3.78e-08 | |||||||
relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G protein-coupled receptors; Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four G protein-coupled receptors, RXFP1-4. Relaxin is the endogenous ligand for RXFP1, which has a large extracellular N-terminal domain containing 10 leucine-rich repeats and a unique low-density lipoprotein type A (LDLa) module which is necessary for receptor activation. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP and nitric oxide. RXFP1 is expressed in various tissues including uterus, ovary, placenta, cerebral cortex, heart, lung and kidney, among others. Pssm-ID: 320631 [Multi-domain] Cd Length: 287 Bit Score: 55.65 E-value: 3.78e-08
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PRK15370 | PRK15370 | type III secretion system effector E3 ubiquitin transferase SlrP; |
49-203 | 4.34e-08 | |||||||
type III secretion system effector E3 ubiquitin transferase SlrP; Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 57.01 E-value: 4.34e-08
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LRR_RI | cd00116 | Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
143-392 | 9.68e-08 | |||||||
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1). Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 54.67 E-value: 9.68e-08
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LRR_RI | cd00116 | Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
70-248 | 1.04e-07 | |||||||
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1). Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 54.67 E-value: 1.04e-07
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LRR_8 | pfam13855 | Leucine rich repeat; |
399-454 | 1.49e-07 | |||||||
Leucine rich repeat; Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 49.06 E-value: 1.49e-07
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LRR_5 | pfam13306 | BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ... |
139-283 | 1.88e-07 | |||||||
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis. Pssm-ID: 463839 [Multi-domain] Cd Length: 127 Bit Score: 50.62 E-value: 1.88e-07
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PLN03210 | PLN03210 | Resistant to P. syringae 6; Provisional |
85-432 | 3.57e-07 | |||||||
Resistant to P. syringae 6; Provisional Pssm-ID: 215633 [Multi-domain] Cd Length: 1153 Bit Score: 54.11 E-value: 3.57e-07
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LRR_RI | cd00116 | Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
230-442 | 4.99e-07 | |||||||
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1). Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 52.74 E-value: 4.99e-07
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PLN00113 | PLN00113 | leucine-rich repeat receptor-like protein kinase; Provisional |
208-473 | 1.83e-06 | |||||||
leucine-rich repeat receptor-like protein kinase; Provisional Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 51.77 E-value: 1.83e-06
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LRR_5 | pfam13306 | BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ... |
92-212 | 1.99e-06 | |||||||
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis. Pssm-ID: 463839 [Multi-domain] Cd Length: 127 Bit Score: 47.92 E-value: 1.99e-06
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PPP1R42 | cd21340 | protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
67-224 | 2.27e-06 | |||||||
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation. Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 49.40 E-value: 2.27e-06
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RNA1 | COG5238 | Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
67-453 | 2.45e-06 | |||||||
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis]; Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 50.94 E-value: 2.45e-06
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7tm_classA_rhodopsin-like | cd00637 | rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ... |
570-831 | 4.70e-06 | |||||||
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections. Pssm-ID: 410626 [Multi-domain] Cd Length: 275 Bit Score: 49.21 E-value: 4.70e-06
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PLN03150 | PLN03150 | hypothetical protein; Provisional |
372-445 | 1.14e-05 | |||||||
hypothetical protein; Provisional Pssm-ID: 178695 [Multi-domain] Cd Length: 623 Bit Score: 49.04 E-value: 1.14e-05
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LRR_8 | pfam13855 | Leucine rich repeat; |
258-314 | 1.89e-05 | |||||||
Leucine rich repeat; Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 42.90 E-value: 1.89e-05
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PRK15387 | PRK15387 | type III secretion system effector E3 ubiquitin transferase SspH2; |
51-273 | 4.07e-05 | |||||||
type III secretion system effector E3 ubiquitin transferase SspH2; Pssm-ID: 185285 [Multi-domain] Cd Length: 788 Bit Score: 47.46 E-value: 4.07e-05
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LRR_4 | pfam12799 | Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ... |
352-389 | 8.89e-05 | |||||||
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains. Pssm-ID: 463713 [Multi-domain] Cd Length: 44 Bit Score: 40.69 E-value: 8.89e-05
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PRK15370 | PRK15370 | type III secretion system effector E3 ubiquitin transferase SlrP; |
333-472 | 1.19e-04 | |||||||
type III secretion system effector E3 ubiquitin transferase SlrP; Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 45.84 E-value: 1.19e-04
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PLN03150 | PLN03150 | hypothetical protein; Provisional |
379-453 | 2.19e-04 | |||||||
hypothetical protein; Provisional Pssm-ID: 178695 [Multi-domain] Cd Length: 623 Bit Score: 44.81 E-value: 2.19e-04
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RNA1 | COG5238 | Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
71-199 | 4.45e-04 | |||||||
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis]; Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 43.63 E-value: 4.45e-04
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LRR_8 | pfam13855 | Leucine rich repeat; |
305-364 | 5.56e-04 | |||||||
Leucine rich repeat; Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 38.66 E-value: 5.56e-04
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LRR_4 | pfam12799 | Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ... |
210-244 | 1.86e-03 | |||||||
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains. Pssm-ID: 463713 [Multi-domain] Cd Length: 44 Bit Score: 36.84 E-value: 1.86e-03
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LRRNT | smart00013 | Leucine rich repeat N-terminal domain; |
34-68 | 3.00e-03 | |||||||
Leucine rich repeat N-terminal domain; Pssm-ID: 214470 [Multi-domain] Cd Length: 33 Bit Score: 36.14 E-value: 3.00e-03
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LRR_5 | pfam13306 | BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ... |
267-335 | 3.94e-03 | |||||||
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis. Pssm-ID: 463839 [Multi-domain] Cd Length: 127 Bit Score: 38.29 E-value: 3.94e-03
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PLN03150 | PLN03150 | hypothetical protein; Provisional |
91-186 | 4.83e-03 | |||||||
hypothetical protein; Provisional Pssm-ID: 178695 [Multi-domain] Cd Length: 623 Bit Score: 40.57 E-value: 4.83e-03
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PLN03150 | PLN03150 | hypothetical protein; Provisional |
71-151 | 7.46e-03 | |||||||
hypothetical protein; Provisional Pssm-ID: 178695 [Multi-domain] Cd Length: 623 Bit Score: 39.80 E-value: 7.46e-03
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Blast search parameters | ||||
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