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Conserved domains on  [gi|1039775817|ref|XP_017177247|]
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sugar phosphate exchanger 3 isoform X2 [Mus musculus]

Protein Classification

sugar phosphate exchanger 3( domain architecture ID 13023818)

sugar phosphate exchanger 3 is not a glucose-6-phosphate (G6P) transporter

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS_SLC37A3 cd17342
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ...
20-476 0e+00

Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340900 [Multi-domain]  Cd Length: 399  Bit Score: 655.54  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817  20 HLAVFLLTFFSYSLLHASRKTFSNVKVSISKQWTPNAFNTSLDLPAEIWSSNHLFPSTEEATLFLGTLDTVFLFSYAVGL 99
Cdd:cd17342     1 HVVVFILTFFSYALLHATRKTFSNVKPSISAEWTPSNSNTSIELHEETWNANPLFPSQDDAALFLGVLDTIFLFSYAIGL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 100 FISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWLHFYNKWFYCGLWIVNGLLQSTGWPCVVAVMGNWFGKAGRGVVF 179
Cdd:cd17342    81 FISGWLGDRLNLRLVLAFGMCSSAITVFLFGVLTEWLHFYNKYLYCILWVLNGLLQSTGWPCVVAIMGNWFGKSSRGFVL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 180 GLWSACASVGNILGAFLASSVLQYGYEYAFLVTASVQFAGGIIIFFGLLVSPeeiglpsigaeesseedsqrplidgaen 259
Cdd:cd17342   161 GLWSACASVGNIIGALLASSVLDYGYEYAFLVTSSLLFAGAIVVFFGLLSSP---------------------------- 212
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 260 eddyepnysiqedravvqvkaisfhqacclPGVIPYSLAYACLKLVNYSFFFWLPFYLSNNFGWKEAEADKLSIWYDVGG 339
Cdd:cd17342   213 ------------------------------PGVIPYSLAYACLKLVNYSFFFWLPFYLSNNFHWKESEADQLSIWYDVGG 262
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 340 IIGGTLLGFISDVLQKRAPVLALSLFLAVGSLVGYSRSPNNKSINALLMTITGFFIGGPSNMVSSAISADLGRQELIQGN 419
Cdd:cd17342   263 IIGGIVAGYISDRMGSRSPVVVVMLLLAIPSLFVYSHSPSDKVLNAFVMTITGFFIGGPANLISSAISADLGRQPQLRGS 342
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1039775817 420 SEALATVTGIVDGTGSIGAAVGQYLVSLIQDNLGWMWVFYFFILMTSCTILFILPLI 476
Cdd:cd17342   343 SEALATVTGIIDGTGSIGAAIGQVLVPLIQNRLGWMWVFYFFIIMTILTIVCILPLL 399
 
Name Accession Description Interval E-value
MFS_SLC37A3 cd17342
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ...
20-476 0e+00

Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340900 [Multi-domain]  Cd Length: 399  Bit Score: 655.54  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817  20 HLAVFLLTFFSYSLLHASRKTFSNVKVSISKQWTPNAFNTSLDLPAEIWSSNHLFPSTEEATLFLGTLDTVFLFSYAVGL 99
Cdd:cd17342     1 HVVVFILTFFSYALLHATRKTFSNVKPSISAEWTPSNSNTSIELHEETWNANPLFPSQDDAALFLGVLDTIFLFSYAIGL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 100 FISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWLHFYNKWFYCGLWIVNGLLQSTGWPCVVAVMGNWFGKAGRGVVF 179
Cdd:cd17342    81 FISGWLGDRLNLRLVLAFGMCSSAITVFLFGVLTEWLHFYNKYLYCILWVLNGLLQSTGWPCVVAIMGNWFGKSSRGFVL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 180 GLWSACASVGNILGAFLASSVLQYGYEYAFLVTASVQFAGGIIIFFGLLVSPeeiglpsigaeesseedsqrplidgaen 259
Cdd:cd17342   161 GLWSACASVGNIIGALLASSVLDYGYEYAFLVTSSLLFAGAIVVFFGLLSSP---------------------------- 212
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 260 eddyepnysiqedravvqvkaisfhqacclPGVIPYSLAYACLKLVNYSFFFWLPFYLSNNFGWKEAEADKLSIWYDVGG 339
Cdd:cd17342   213 ------------------------------PGVIPYSLAYACLKLVNYSFFFWLPFYLSNNFHWKESEADQLSIWYDVGG 262
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 340 IIGGTLLGFISDVLQKRAPVLALSLFLAVGSLVGYSRSPNNKSINALLMTITGFFIGGPSNMVSSAISADLGRQELIQGN 419
Cdd:cd17342   263 IIGGIVAGYISDRMGSRSPVVVVMLLLAIPSLFVYSHSPSDKVLNAFVMTITGFFIGGPANLISSAISADLGRQPQLRGS 342
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1039775817 420 SEALATVTGIVDGTGSIGAAVGQYLVSLIQDNLGWMWVFYFFILMTSCTILFILPLI 476
Cdd:cd17342   343 SEALATVTGIIDGTGSIGAAIGQVLVPLIQNRLGWMWVFYFFIIMTILTIVCILPLL 399
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
84-478 8.90e-30

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 119.59  E-value: 8.90e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817  84 LGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWLHFYnkwfycGLWIVNGLLQSTGWPCVV 163
Cdd:COG2271    47 LGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLL------LLRFLLGLGEAGFFPAAL 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 164 AVMGNWFGKAGRGVVFGLWSACASVGNILGAFLASSVLQ-YGYEYAFLVTASVQFAGGIIIFFGLlvspeeiglpsigae 242
Cdd:COG2271   121 KLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAaFGWRAAFLILGLPGLLLALLRFWLL--------------- 185
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 243 esseedsqrplidgaeneddyepnysiqedravvqvkaisfhqacclpgvipySLAYACLKLVNYSFFFWLPFYLSNNFG 322
Cdd:COG2271   186 -----------------------------------------------------ALAYFLVYFALYGFLTWLPTYLVEVRG 212
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 323 WKEAEADKLSIWYDVGGIIGGTLLGFISDVLQKR-APVLALSLFLAVGSLVGYSRSPNNkSINALLMTITGFFIGGPSNM 401
Cdd:COG2271   213 LSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrKLVLAIGLLLAALALLLLALLPSP-ALAIALLFLAGFGLGGAFGL 291
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039775817 402 VSSAISADLGRqeliqgnsEALATVTGIVDGTGSIGAAVGQYLVSLIQDNLGWMWVFYFFILMTSCTILFILPLIVR 478
Cdd:COG2271   292 LWALAAELFPK--------KARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRE 360
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
84-454 8.27e-22

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 97.06  E-value: 8.27e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817  84 LGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWlhfynkWFYCGLWIVNGLLQSTGWPCVV 163
Cdd:TIGR00881  32 LGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSL------WVMAALWALNGIFQGMGWPPCG 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 164 AVMGNWFGKAGRGVVFGLWSACASVGNILGA--FLASSVLQYGYEYAFLVTASVQFAGGIIIFFGLLVSPEEIGLPSIGA 241
Cdd:TIGR00881 106 RTVTKWFSRSERGTWVSFWNCSHNVGGGLLPplVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLRDSPQSCGLPPAEE 185
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 242 EESSEEDSQRPLidgAENEddyepnysiqedravVQVKAISFHQACCLPGVIPYSLAYACLKLVNYSFFFWLPFYLSNNF 321
Cdd:TIGR00881 186 MPNEEPDGDAEK---KEEE---------------LTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEK 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 322 GWKEAEADKLSIWYDVGGIIGGTLLGFISDVL--QKRAPVLALSLFLAVGSLVGYSRSP-NNKSINALLMTITGFFIGGP 398
Cdd:TIGR00881 248 GFSKEKASWAFTLYELGGLVGTLLAGWLSDKLfnGRRGPLAVFFMALIIVSLLVYWLNPaANPLMDLICLFALGFLVYGP 327
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1039775817 399 SNMVSSAISadlgrqELiqGNSEALATVTGIVDGTGSIGAAVGQYLVSLIQDNLGW 454
Cdd:TIGR00881 328 QMLIGVIAS------EL--APKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFGW 375
PRK11663 PRK11663
glucose-6-phosphate receptor/MFS transporter UhpC;
84-476 1.70e-21

glucose-6-phosphate receptor/MFS transporter UhpC;


Pssm-ID: 183266 [Multi-domain]  Cd Length: 434  Bit Score: 96.70  E-value: 1.70e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817  84 LGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTewlhfyNKWFYCGLWIVNGLLQSTGWPCVV 163
Cdd:PRK11663   60 IGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFSS------SLWAFALLWVLNAFFQGWGWPVCA 133
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 164 AVMGNWFGKAGRGVVFGLWSACASVGNILGAFLASSV-LQYGYEYAFLVTASVQFAGGIIIFFGLLVSPEEIGLPSIGae 242
Cdd:PRK11663  134 KLLTAWYSRTERGGWWAIWNTAHNVGGALIPLVVGAIaLHYGWRYGMMIAGIIAIVVGLFLCWRLRDKPQAMGLPSVG-- 211
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 243 esseEDSQRPLIDGAENEDDYEPNYSIQEdRAVVQVKAIsFHQACClpgvipYSLAYACLKLVNYsfffWLPFYLSNNFG 322
Cdd:PRK11663  212 ----EWRHDALELAQQQEGAGLSRKEILT-KYVLLNPYI-WLLSFS------YVLVYVVRAAIND----WGNLYMSETLG 275
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 323 WKEAEADKLSIWYDVGGIIGGTLLGFISDVL--QKRAP---VLALSLFLAVGSLvgYSRSPNNKSINALLMTITGFFIGG 397
Cdd:PRK11663  276 VDLVTANSAVSMFELGGFIGALVAGWGSDKLfnGNRGPmnlIFAAGILLSVGSL--WLMPFASYVMQAACFFTIGFFVFG 353
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 398 PSNMVSSAiSADLGRQeliqgnsEALATVTGIVDGTGSIGAAVGQYLVSLIQDNLGWMWvFYFFILMTSCTI-LFILPLI 476
Cdd:PRK11663  354 PQMLIGMA-AAECSHK-------EAAGAATGFVGLFAYLGAALSGYPLAKVLEIWHWTG-FFVVISIAAGISaLLLLPFL 424
MFS_1 pfam07690
Major Facilitator Superfamily;
84-441 9.08e-16

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 78.61  E-value: 9.08e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817  84 LGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWlhfynkWFYCGLWIVNGLLQSTGWPCVV 163
Cdd:pfam07690  34 IGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSL------WLLLVLRVLQGLGAGALFPAAL 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 164 AVMGNWFGKAGRGVVFGLWSACASVGNILGAFLASSVL-QYGYEYAFLVTASVQFAGGIIIFFGllvspeeiglpsigae 242
Cdd:pfam07690 108 ALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAsLFGWRAAFLILAILSLLAAVLLLLP---------------- 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 243 esseedsqrplidgaenedDYEPNYSIQEDRAVVQVKAISFHQACCLPGVIPYSLAYACLKLVNYSFFFWLPFYLsNNFG 322
Cdd:pfam07690 172 -------------------RPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQ-EVLG 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 323 WKEAEADKLSIWYDVGGIIGGTLLGFISDVLQKRAPVLALSLFLAVGSL-VGYSRSPNNKSINALLMTITGFFIGGPSNM 401
Cdd:pfam07690 232 LSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALgLLLLSLTLSSLWLLLALLLLGFGFGLVFPA 311
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1039775817 402 VSSAISADLGRqeliqgnsEALATVTGIVDGTGSIGAAVG 441
Cdd:pfam07690 312 LNALVSDLAPK--------EERGTASGLYNTAGSLGGALG 343
 
Name Accession Description Interval E-value
MFS_SLC37A3 cd17342
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ...
20-476 0e+00

Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340900 [Multi-domain]  Cd Length: 399  Bit Score: 655.54  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817  20 HLAVFLLTFFSYSLLHASRKTFSNVKVSISKQWTPNAFNTSLDLPAEIWSSNHLFPSTEEATLFLGTLDTVFLFSYAVGL 99
Cdd:cd17342     1 HVVVFILTFFSYALLHATRKTFSNVKPSISAEWTPSNSNTSIELHEETWNANPLFPSQDDAALFLGVLDTIFLFSYAIGL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 100 FISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWLHFYNKWFYCGLWIVNGLLQSTGWPCVVAVMGNWFGKAGRGVVF 179
Cdd:cd17342    81 FISGWLGDRLNLRLVLAFGMCSSAITVFLFGVLTEWLHFYNKYLYCILWVLNGLLQSTGWPCVVAIMGNWFGKSSRGFVL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 180 GLWSACASVGNILGAFLASSVLQYGYEYAFLVTASVQFAGGIIIFFGLLVSPeeiglpsigaeesseedsqrplidgaen 259
Cdd:cd17342   161 GLWSACASVGNIIGALLASSVLDYGYEYAFLVTSSLLFAGAIVVFFGLLSSP---------------------------- 212
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 260 eddyepnysiqedravvqvkaisfhqacclPGVIPYSLAYACLKLVNYSFFFWLPFYLSNNFGWKEAEADKLSIWYDVGG 339
Cdd:cd17342   213 ------------------------------PGVIPYSLAYACLKLVNYSFFFWLPFYLSNNFHWKESEADQLSIWYDVGG 262
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 340 IIGGTLLGFISDVLQKRAPVLALSLFLAVGSLVGYSRSPNNKSINALLMTITGFFIGGPSNMVSSAISADLGRQELIQGN 419
Cdd:cd17342   263 IIGGIVAGYISDRMGSRSPVVVVMLLLAIPSLFVYSHSPSDKVLNAFVMTITGFFIGGPANLISSAISADLGRQPQLRGS 342
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1039775817 420 SEALATVTGIVDGTGSIGAAVGQYLVSLIQDNLGWMWVFYFFILMTSCTILFILPLI 476
Cdd:cd17342   343 SEALATVTGIIDGTGSIGAAIGQVLVPLIQNRLGWMWVFYFFIIMTILTIVCILPLL 399
MFS_SLC37A1_2 cd17344
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ...
22-479 4.36e-100

Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340902 [Multi-domain]  Cd Length: 400  Bit Score: 306.55  E-value: 4.36e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817  22 AVFLLTFFSYSLLHASRKTFSNVKVSISKQWTPNAFNTSLDLPAEIWSSNHLFPSTEEATLfLGTLDTVFLFSYAVGLFI 101
Cdd:cd17344     3 FILVLTFLAYACYHLSRKPISIVKSVLHPNCSALIPPPNIVLNNTTWCGWAPFDGKNGTEL-LGALDSAFLFAYAIGMFF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 102 SGIIGDRLNLRWVLSFGMCSSAFVVFVFGtLTEWLHFYNKWFYCGLWIVNGLLQSTGWPCVVAVMGNWFGKAGRGVVFGL 181
Cdd:cd17344    82 SGHIGERLPLRYFLSFGMLLSGLFTALFG-LGYYWNIHSLWYFVVVQILAGLFQSTGWPSVVACVGNWFGKGKRGLIMGI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 182 WSACASVGNILGAFLASSVLQYGYEYAFLVTASVQFAGGIIIFFGLLVSPeeiglpsigaeesseedsqrplidgaened 261
Cdd:cd17344   161 WNSHTSVGNILGSLIAGIFVSSAWGLSFIVPGIIIAAMGVLVFLFLVEHP------------------------------ 210
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 262 dyepnysiqedravvqvkaisfhqacclPGVIPYSLAYACLKLVNYSFFFWLPFYLSNNFGWKEAEADKLSIWYDVGGII 341
Cdd:cd17344   211 ----------------------------PGVIEFSLCLFFAKLVSYTFLYWLPLYISNTAILSAKKAGDLSTLFDVGGIV 262
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 342 GGTLLGFISDVLQKRAPVLALSLFLAVGSLVGYSR-SPNNKSINALLMTITGFFIGGPSNMVSSAISADLGRQELIQGNS 420
Cdd:cd17344   263 GGILAGYISDYTGGRATTCAAMLILAAPMLFIYNYfGQVSMTTNIVLLIVCGLLVNGPYALITTAVSADLGTHKSLKGNA 342
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1039775817 421 EALATVTGIVDGTGSIGAAVGQYLVSLIQDnLGWMWVFYFFILMTSCTILFILPLIVRE 479
Cdd:cd17344   343 RALATVTAIIDGTGSIGAALGPLLAGLISS-RGWNNVFYMLIAADVCAGLLLTRLVYKE 400
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
23-476 2.59e-98

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 300.73  E-value: 2.59e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817  23 VFLLTFFSYSLLHASRKTFSNVKVSISKQWtpnafntsldlpaeiwssnhlfpstEEATLFLGTLDTVFLFSYAVGLFIS 102
Cdd:cd17312     4 IFLGVFLGYAAYYVCRKNFSVAKPPIVEEI-------------------------GLSKDDLGIIGSAFLIAYAVGKFIS 58
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 103 GIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEwlhfynKWFYCGLWIVNGLLQSTGWPCVVAVMGNWFGKAGRGVVFGLW 182
Cdd:cd17312    59 GFLSDRSNIRRFMSAGLLLSALANIFMGFSTS------LWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIW 132
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 183 SACASVGNILGAFLASSVLQ-YGYEYAFLVTASVQFAGGIIIFFGLLVSPeeiglpsigaeesseedsqrplidgaened 261
Cdd:cd17312   133 STSHNFGGILAPILAASLASyYGWRAAFLVPGIVGLVVAIILFFFLRDSP------------------------------ 182
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 262 dyepnysiqedravvqvkaisfhqacclPGVIPYSLAYACLKLVNYSFFFWLPFYLSNNFGWKEAEADKLSIWYDVGGII 341
Cdd:cd17312   183 ----------------------------PYVWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIA 234
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 342 GGTLLGFISDVL--QKRAPVLALSLFLAVGSLVGYSRSPNNKSINALLMTITGFFIGGPSNMVSSAISADLGRQeliqgn 419
Cdd:cd17312   235 GTILAGLLSDKLfgGRRAPIAVIYMLLMTLSLALFWFFPHNKLLSIVLLFLIGFFVGGPINLIGGAAAQDIGRK------ 308
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1039775817 420 sEALATVTGIVDGTGSIGAAVGQYLVSLIQDNLGWMWVFYFFILMTSCTILFILPLI 476
Cdd:cd17312   309 -EAAGTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISAALLSVLLLLSLW 364
MFS_GlpT cd17345
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ...
84-475 1.27e-31

Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340903 [Multi-domain]  Cd Length: 411  Bit Score: 125.82  E-value: 1.27e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817  84 LGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWlhFYNKWFYCGLWIVNGLLQSTGWPCVV 163
Cdd:cd17345    40 IGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVPSA--TSSVGLMFILLFLNGWFQGMGWPPSG 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 164 AVMGNWFGKAGRGVVFGLWSACASVGN----ILGAFLASSVLQYGYEYAFLVTASVQFAGGIIIFFGLLVSPEEIGLPSI 239
Cdd:cd17345   118 RTMVHWFSKKERGTWTSIWNISHNVGGglvgPLAGLGLAIFGDGWWRGAFIFPAIIAIIVAVIVLFLGKDTPESEGLPPI 197
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 240 gAEESSEEDSQrplidgaENEDDYEPNYSIQEdravvqvkaISFHQACCLPGVIPYSLAYACLKLVNYSFFFWLPFYLSN 319
Cdd:cd17345   198 -EEYKGDYPEE-------ADGEEEEQELSAWE---------IFVKYVLKNKLLWYIAIANVFVYLVRYGILDWAPTYLSE 260
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 320 NFGWKEAEADKLSIWYDVGGIIGGTLLGFISDVLQK--RAPVLALSLFLAVGSLVGYSRSPNNKSINALLmTITGFFIGG 397
Cdd:cd17345   261 VKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLFKgrRAPTGIIFMILVIVALIVYWLAPNVLVDLIAL-IALGFLIYG 339
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 398 PSNMVS-SAIsadlgrqELIQGNseALATVTGIVDGTGSI-GAAVGQYLVSLIQDNLGWMWVFYFFILMTSCTILFILPL 475
Cdd:cd17345   340 PVMLIGlQAL-------ELVPKK--AAGTAAGLTGLFGYLgGSVLATALIGIIVDHFGWNGGFIVLLASCILAIIFLALV 410
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
84-478 8.90e-30

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 119.59  E-value: 8.90e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817  84 LGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWLHFYnkwfycGLWIVNGLLQSTGWPCVV 163
Cdd:COG2271    47 LGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLL------LLRFLLGLGEAGFFPAAL 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 164 AVMGNWFGKAGRGVVFGLWSACASVGNILGAFLASSVLQ-YGYEYAFLVTASVQFAGGIIIFFGLlvspeeiglpsigae 242
Cdd:COG2271   121 KLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAaFGWRAAFLILGLPGLLLALLRFWLL--------------- 185
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 243 esseedsqrplidgaeneddyepnysiqedravvqvkaisfhqacclpgvipySLAYACLKLVNYSFFFWLPFYLSNNFG 322
Cdd:COG2271   186 -----------------------------------------------------ALAYFLVYFALYGFLTWLPTYLVEVRG 212
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 323 WKEAEADKLSIWYDVGGIIGGTLLGFISDVLQKR-APVLALSLFLAVGSLVGYSRSPNNkSINALLMTITGFFIGGPSNM 401
Cdd:COG2271   213 LSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrKLVLAIGLLLAALALLLLALLPSP-ALAIALLFLAGFGLGGAFGL 291
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039775817 402 VSSAISADLGRqeliqgnsEALATVTGIVDGTGSIGAAVGQYLVSLIQDNLGWMWVFYFFILMTSCTILFILPLIVR 478
Cdd:COG2271   292 LWALAAELFPK--------KARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRE 360
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
84-454 8.27e-22

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 97.06  E-value: 8.27e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817  84 LGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWlhfynkWFYCGLWIVNGLLQSTGWPCVV 163
Cdd:TIGR00881  32 LGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSL------WVMAALWALNGIFQGMGWPPCG 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 164 AVMGNWFGKAGRGVVFGLWSACASVGNILGA--FLASSVLQYGYEYAFLVTASVQFAGGIIIFFGLLVSPEEIGLPSIGA 241
Cdd:TIGR00881 106 RTVTKWFSRSERGTWVSFWNCSHNVGGGLLPplVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLRDSPQSCGLPPAEE 185
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 242 EESSEEDSQRPLidgAENEddyepnysiqedravVQVKAISFHQACCLPGVIPYSLAYACLKLVNYSFFFWLPFYLSNNF 321
Cdd:TIGR00881 186 MPNEEPDGDAEK---KEEE---------------LTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEK 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 322 GWKEAEADKLSIWYDVGGIIGGTLLGFISDVL--QKRAPVLALSLFLAVGSLVGYSRSP-NNKSINALLMTITGFFIGGP 398
Cdd:TIGR00881 248 GFSKEKASWAFTLYELGGLVGTLLAGWLSDKLfnGRRGPLAVFFMALIIVSLLVYWLNPaANPLMDLICLFALGFLVYGP 327
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1039775817 399 SNMVSSAISadlgrqELiqGNSEALATVTGIVDGTGSIGAAVGQYLVSLIQDNLGW 454
Cdd:TIGR00881 328 QMLIGVIAS------EL--APKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFGW 375
PRK11663 PRK11663
glucose-6-phosphate receptor/MFS transporter UhpC;
84-476 1.70e-21

glucose-6-phosphate receptor/MFS transporter UhpC;


Pssm-ID: 183266 [Multi-domain]  Cd Length: 434  Bit Score: 96.70  E-value: 1.70e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817  84 LGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTewlhfyNKWFYCGLWIVNGLLQSTGWPCVV 163
Cdd:PRK11663   60 IGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFSS------SLWAFALLWVLNAFFQGWGWPVCA 133
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 164 AVMGNWFGKAGRGVVFGLWSACASVGNILGAFLASSV-LQYGYEYAFLVTASVQFAGGIIIFFGLLVSPEEIGLPSIGae 242
Cdd:PRK11663  134 KLLTAWYSRTERGGWWAIWNTAHNVGGALIPLVVGAIaLHYGWRYGMMIAGIIAIVVGLFLCWRLRDKPQAMGLPSVG-- 211
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 243 esseEDSQRPLIDGAENEDDYEPNYSIQEdRAVVQVKAIsFHQACClpgvipYSLAYACLKLVNYsfffWLPFYLSNNFG 322
Cdd:PRK11663  212 ----EWRHDALELAQQQEGAGLSRKEILT-KYVLLNPYI-WLLSFS------YVLVYVVRAAIND----WGNLYMSETLG 275
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 323 WKEAEADKLSIWYDVGGIIGGTLLGFISDVL--QKRAP---VLALSLFLAVGSLvgYSRSPNNKSINALLMTITGFFIGG 397
Cdd:PRK11663  276 VDLVTANSAVSMFELGGFIGALVAGWGSDKLfnGNRGPmnlIFAAGILLSVGSL--WLMPFASYVMQAACFFTIGFFVFG 353
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 398 PSNMVSSAiSADLGRQeliqgnsEALATVTGIVDGTGSIGAAVGQYLVSLIQDNLGWMWvFYFFILMTSCTI-LFILPLI 476
Cdd:PRK11663  354 PQMLIGMA-AAECSHK-------EAAGAATGFVGLFAYLGAALSGYPLAKVLEIWHWTG-FFVVISIAAGISaLLLLPFL 424
MFS_SLC37A4 cd17343
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ...
21-245 2.41e-18

Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340901 [Multi-domain]  Cd Length: 409  Bit Score: 87.00  E-value: 2.41e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817  21 LAVFLLTFFSYSLLHASRKTFSNVKVSISKqwtpnafNTSLDLPAeiwssnhlfpsteeatlfLGTLDTVFLFSYAVGLF 100
Cdd:cd17343     2 LTIFASMFVGYTLYYFNRKSFSFVLPSLMN-------ELGLDKSD------------------LGLITSSQSLAYAISKF 56
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 101 ISGIIGDRLNLRWVLSFGMCSSAFVVFVFGtltewlHFYNKWFYCGLWIVNGLLQSTGWPCVVAVMGNWFGKAGRGVVFG 180
Cdd:cd17343    57 IGGVLSDQISARWLFSSGLVLSGLTTVAFS------GSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWS 130
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039775817 181 LWSACASVGNILGAFLASSV-LQYGYEYAFLVTASVQFAGGIIIFFGLLVSPEEIGLPSIGAEESS 245
Cdd:cd17343   131 VLSTSMNLAGSLGPILATLLaLSYGWRSTLSISGTVAVVMSVVCLLFIKNEPSDVGLNNIEEEESK 196
MFS_UhpC cd17488
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ...
84-476 8.54e-18

Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341041 [Multi-domain]  Cd Length: 364  Bit Score: 84.76  E-value: 8.54e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817  84 LGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWLHFYNkwfycgLWIVNGLLQSTGWPCVV 163
Cdd:cd17488    40 IGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIINILFGFSSSLWAFAV------LWTLNAFFQGWGWPPCA 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 164 AVMGNWFGKAGRGVVFGLWSACASVGNILGAFLASSV-LQYGYEYAFLVTASVQFAGGIIIFFGLLVSPEEIGLPSIGae 242
Cdd:cd17488   114 RLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAaLTYGWRAGMYVPGIIAILMGIVLCWRLRDRPPYIWLLAFC-- 191
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 243 esseedsqrplidgaeneddyepnysiqedravvqvkaisfhqacclpgvipYSLAYACLKLVNYsfffWLPFYLSNNFG 322
Cdd:cd17488   192 ----------------------------------------------------YVLVYVVRTAIND----WGNLYLSETHG 215
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 323 WKEAEADKLSIWYDVGGIIGGTLLGFISDVLQK--RAP---VLALSLFLAVGSLvgYSRSPNNKSINALLMTITGFFIGG 397
Cdd:cd17488   216 YSLVKANSAVSLFEVGGLIGALVAGWGSDKLFKgnRGPmnlIFALGLLVSVGAL--WLVPVHSYWLLATCFFTIGFFVFG 293
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039775817 398 PSNMVSSAiSADLGRQeliqgnsEALATVTGIVDGTGSIGAAVGQYLVSLIQDNLGWMWVFYFFILMTSCTILFILPLI 476
Cdd:cd17488   294 PQMLIGMA-AAECSHK-------DAAGSATGFVGLFAYLGAALAGYPLAKVIESWGWSGFFIVISIAAAISGLLLLPLL 364
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
84-475 2.57e-16

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 80.31  E-value: 2.57e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817  84 LGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWLHFYnkwfycGLWIVNGLLQSTGWPCVV 163
Cdd:cd17319    40 YGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLY------VLRFLLGVAEAGFFPGAI 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 164 AVMGNWFGKAGRGVVFGLWSACASVGNILGAFLASSVLQY-GYEYAFLVTASVQFAGGIIIFFGLlvspeeiglpsigae 242
Cdd:cd17319   114 KALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLfGWRWAFIIEGLLGLLLAVLWWFYL--------------- 178
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 243 esseedsqrplidgaeneddyepnysiqedravvqvkaisfhqacclPGVIPYSLAYACLKLVNYSFFFWLPFYLSNNFG 322
Cdd:cd17319   179 -----------------------------------------------RQVWGLALGYFGINYALYGLLTWLPTYLKQARG 211
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 323 WKEAEADKLSIWYDVGGIIGGTLLGFISD--VLQKRAPVLALSLFLAVGSLVGYSRSPnNKSINALLMTITGFFIGGPSn 400
Cdd:cd17319   212 FSLKQVGLLAAIPFLAGAIGMILGGRLSDrlLRGARRLVIIIGLLLAAVGLLLAYLTT-SPVVAVILLSLAGFGIGAAS- 289
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039775817 401 MVSSAISADLGRqeliqgnSEALATVTGIVDGTGSIGAAVGQYLVS-LIQDNLGWMWVFYFFILMTSCTILFILPL 475
Cdd:cd17319   290 PVFWSLPADLLP-------GEAAATAGGLINSGGNLGGFVAPLLIGyLVDATGSYTAAFLFLAAVALLAALLVLLL 358
MFS_1 pfam07690
Major Facilitator Superfamily;
84-441 9.08e-16

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 78.61  E-value: 9.08e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817  84 LGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWlhfynkWFYCGLWIVNGLLQSTGWPCVV 163
Cdd:pfam07690  34 IGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSL------WLLLVLRVLQGLGAGALFPAAL 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 164 AVMGNWFGKAGRGVVFGLWSACASVGNILGAFLASSVL-QYGYEYAFLVTASVQFAGGIIIFFGllvspeeiglpsigae 242
Cdd:pfam07690 108 ALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAsLFGWRAAFLILAILSLLAAVLLLLP---------------- 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 243 esseedsqrplidgaenedDYEPNYSIQEDRAVVQVKAISFHQACCLPGVIPYSLAYACLKLVNYSFFFWLPFYLsNNFG 322
Cdd:pfam07690 172 -------------------RPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQ-EVLG 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 323 WKEAEADKLSIWYDVGGIIGGTLLGFISDVLQKRAPVLALSLFLAVGSL-VGYSRSPNNKSINALLMTITGFFIGGPSNM 401
Cdd:pfam07690 232 LSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALgLLLLSLTLSSLWLLLALLLLGFGFGLVFPA 311
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1039775817 402 VSSAISADLGRqeliqgnsEALATVTGIVDGTGSIGAAVG 441
Cdd:pfam07690 312 LNALVSDLAPK--------EERGTASGLYNTAGSLGGALG 343
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
84-479 1.03e-15

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 78.77  E-value: 1.03e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817  84 LGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWLHFynkwFYCGLWIvnGLLQSTGWPCVV 163
Cdd:COG2223    42 LGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLL----LLLGLLL--GIGGGGSFAVGI 115
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 164 AVMGNWFGKAGRGVVFGLWSACASVGNILGAFLASSVLQ-YGYEYAFLVTASVQFAGGIIIFFGLLVSPEeiglpsigae 242
Cdd:COG2223   116 ALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAaFGWRNAFLILGILLLVVAVLAWLFLRDPPA---------- 185
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 243 esseedsqrplidgaeneddyepnysiqEDRAVVQVKAISFHQACCLPGVIPYSLAYACLKLVNYSFFFWLPFYLSNNFG 322
Cdd:COG2223   186 ----------------------------GAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFG 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 323 WKEAEADKLSIWYDVGGIIGGTLLGFISDVLqKRAPVLALSLFLAVGSLVGYSRSPNNKSINALLMTITGFFIGGPSNMV 402
Cdd:COG2223   238 LSAATAGLLAALFALLGALGRPLGGWLSDRI-GGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAV 316
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039775817 403 SSAISADLGRqeliqgnsEALATVTGIVDGTGSIGAAVGQYLVSLIQDNLG-WMWVFYFFILMTSCTILFILPLIVRE 479
Cdd:COG2223   317 FALVPDIFPT--------KNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLLLYRRP 386
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
89-444 2.19e-15

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 78.06  E-value: 2.19e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817  89 TVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFvfgtLTEWLHfyNKWFYCGLWIVNGLLQSTGWPCVVAVMGN 168
Cdd:cd17327    48 TVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTL----LTAAVK--NFGGLIALRFFLGLFESGVFPGFILYLGM 121
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 169 WFGKAGRGVVFGLWSACASVGNILGAFLASSVLQ-------YGYEYAFLVTASVQFAGGIIIFFGLLVSPEEIGLPSiga 241
Cdd:cd17327   122 WYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKilgvgglAGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLT--- 198
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 242 EESSEEDSQRplidgaeneddyepnysIQEDRAVVQVKAISFHQ---ACCLPGVIPYSLAYACLKLVNYSFFFWLPFYLS 318
Cdd:cd17327   199 EEEKELAVER-----------------LRANQTGKGDQKFKWKQikeAFKDPRTWLLFLFFFCSQITNNGISNFLPLILK 261
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 319 NNfGWKEAEADKLSIWYDVGGIIGGTLLGFISDVLQKRAP-VLALSLFLAVGSLVGYSRSPNNKSINALLMTITGFFIGG 397
Cdd:cd17327   262 SL-GFYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGLfAIFACVLALVGSIILLAAPNPPGAYFAAYILGGGSYAGF 340
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 1039775817 398 PSNM--VSSAISADLGRqeliqgnsealATVTGIVDGTGSIGAAVGQYL 444
Cdd:cd17327   341 PILLswISSNCAGYTKR-----------ATVLAIMLIFYNVGNIVAPQI 378
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
81-473 1.00e-14

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 75.54  E-value: 1.00e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817  81 TLFLGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWlhfynkWFYCGLWIVNGLLQSTGWP 160
Cdd:cd06174    30 ASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSF------WLLLLGRFLLGLGSGLIDP 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 161 CVVAVMGNWFGKAGRGVVFGLWSACASVGNILGAFLASSVLQYGYEYAFLVTASVQFAGGIIIFFGLLVSPEEIGLPSIG 240
Cdd:cd06174   104 AVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAK 183
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 241 AEESSEEDSQRPLIDGAENeddyepnysiqedravvqvkaisfhqacclPGVIPYSLAYACLKLVNYSFFFWLPFYLSNN 320
Cdd:cd06174   184 NEEASSKSVLKLLKRVLKN------------------------------PGLWLLLLAIFLVNLAYYSFSTLLPLFLLDL 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 321 FGWKEAEADKLSIWYDVGGIIGGTLLGFISDVLQKRAPVLALSLFLAVGSLVGYSRSPNNKSInALLMTITGFFIGGPSN 400
Cdd:cd06174   234 GGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLL-LLLLLLLGFGLGGLLP 312
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039775817 401 MVSSAISadlgrqelIQGNSEALATVTGIVDGTGSIGAAVGQYLVSLIQD-NLGWMWVFYFFILMTSCTILFIL 473
Cdd:cd06174   313 LSFALIA--------ELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAaTFGLTGAFLVLAVLLLLAAILLL 378
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
84-440 1.57e-14

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 74.63  E-value: 1.57e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817  84 LGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWlhfynkWFYCGLWIVNGLLQSTGWPCVV 163
Cdd:COG2814    47 AGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSL------WLLLAARFLQGLGAGALFPAAL 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 164 AVMGNWFGKAGRGVVFGLWSACASVGNILGAFLASSVLQY-GYEYAFLVTASVQFAGGIIIFFGLLVSPEEIGLPSIGAE 242
Cdd:COG2814   121 ALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLfGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSL 200
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 243 ESSEEDsqrplidgaeneddyepnysiqedravvqvkaisfhqacclPGVIPYSLAYACLKLVNYSFFFWLPFYLSNNFG 322
Cdd:COG2814   201 RELLRR-----------------------------------------PRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLG 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 323 WKEAEADKLSIWYDVGGIIGGTLLGFISDVLQKRaPVLALSLFLAVGSLVGYSRSPNNKSInALLMTITGFFIGGPSNMV 402
Cdd:COG2814   240 LSASAAGLLLALFGLGGVLGALLAGRLADRFGRR-RLLLIGLLLLALGLLLLALAGSLWLL-LLALFLLGFGFGLLFPLL 317
                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 1039775817 403 SSAISADLGRqeliqgnsEALATVTGIVDGTGSIGAAV 440
Cdd:COG2814   318 QALVAELAPP--------EARGRASGLYNSAFFLGGPL 347
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
82-473 3.21e-13

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 71.07  E-value: 3.21e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817  82 LFLGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWlhfynkWFYCGLWIVNGLLQSTGWPC 161
Cdd:cd17325    31 AQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSY------WQLLLARFLQGLASAAVWPA 104
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 162 VVAVMGNWFGKAGRGVVFGLWSACASVGNILGAFLASSVLQ-YGYEYAFLVTASVQFAGGIIIFFGLlvspeeiglpsig 240
Cdd:cd17325   105 AMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADaLGYRAPFLVCAALALLALVLALLLL------------- 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 241 aeesseedsqrplidgaenEDDYEPNYSIQEDRAVVQVKAISFHQAcclPGVIPYSLAYACLKLVNYSFFFWLPFYLSNN 320
Cdd:cd17325   172 -------------------PEPRPPPNKRAVSAARLRSGLRLLLRD---RRLLALFLAIFVLAFAFGALEPFLPLYAAEL 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 321 FGWKEAEADKLSIWYDVGGIIGGTLLGFISDVLQKRaPVLALSLFLAVGSLVGYSRSPnnksiNALLMTITGFFIGGPSN 400
Cdd:cd17325   230 GGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRK-PLILIGLLLSAVALLLLPLAT-----SFWLLLLLLALLGLGLG 303
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039775817 401 MVSSAISADLGRqeliQGNSEALATVTGIVDGTGSIGAAVGQYLVSLIQDNLGWMWVFYFF-ILMTSCTILFIL 473
Cdd:cd17325   304 LVFPATLALLAD----IVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAaALLLLAAVLFLL 373
glpT PRK11273
glycerol-3-phosphate transporter;
94-477 4.31e-12

glycerol-3-phosphate transporter;


Pssm-ID: 236889 [Multi-domain]  Cd Length: 452  Bit Score: 67.81  E-value: 4.31e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817  94 SYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLtEW----------LHFYNKWFycglwivngllQSTGWPCVV 163
Cdd:PRK11273   75 AYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFV-PWatssiavmfvLLFLCGWF-----------QGMGWPPCG 142
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 164 AVMGNWFGKAGRGVVFGLWSACASVGNILGA--FLASSVLQYGYEYAFLVTASVQFAGGIIIFFGLLVSPEEIGLPSIga 241
Cdd:PRK11273  143 RTMVHWWSQKERGGIVSVWNCAHNVGGGLPPllFLLGMAWFNDWHAALYMPAFAAILVALFAFAMMRDTPQSCGLPPI-- 220
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 242 eesseedsqrplidgAENEDDYEPNYSiQEDRAVVQVKAISFHQAccLPGVIPYSLAYA--CLKLVNYSFFFWLPFYLSN 319
Cdd:PRK11273  221 ---------------EEYKNDYPDDYN-EKHEQELTAKQIFMQYV--LPNKLLWYIAIAnvFVYLLRYGILDWSPTYLKE 282
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 320 NfgwKEAEADKLSiW----YDVGGIIGGTLLGFISDVLQK--RAPVLALSLFL-AVGSLVGYSRSPNNKSINALLMTITG 392
Cdd:PRK11273  283 V---KHFALDKSS-WayflYEYAGIPGTLLCGWMSDKVFRgnRGATGVFFMTLvTIATIVYWLNPAGNPTVDMACMIVIG 358
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 393 FFIGGPSNMVssaisadlGRQELIQGNSEALATVTGIVDGTGSIGAAV-GQYLVSLIQDNLGWMWVfyfFILMTSCTILF 471
Cdd:PRK11273  359 FLIYGPVMLI--------GLHALELAPKKAAGTAAGFTGLFGYLGGSVaASAIVGYTVDFFGWDGG---FMVMIGGSILA 427

                  ....*.
gi 1039775817 472 ILPLIV 477
Cdd:PRK11273  428 VILLIV 433
uhpT PRK09556
hexose-6-phosphate:phosphate antiporter;
81-398 3.21e-11

hexose-6-phosphate:phosphate antiporter;


Pssm-ID: 236564 [Multi-domain]  Cd Length: 467  Bit Score: 65.45  E-value: 3.21e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817  81 TLFLGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWLHfYNKWFYCGLWIVNGLLQSTGWP 160
Cdd:PRK09556   63 TTELGMIGLGFSITYGVGKTLVGYYADGKNTKQFLPFLLILSAICMLGFGASLGSGS-VSLGLMIALWALSGFFQSTGGP 141
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 161 CVVAVMGNWFGKAGRGVVFGLWSACASVGNILGAFLA---SSVLQYGYEYAFLVTASVqfAGGIIIFFGLLV---SPEEI 234
Cdd:PRK09556  142 CSYSTITRWTPRRKRGRFLGFWNISHNLGGAGAGGVAlwgANYFFDGHVIGMFIFPSI--IALIIGFIGLRYgsdSPEEL 219
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 235 GL---PSIGAEESSEEDsqrplidgAENEDDYEPNYSIQEdRAVVQVKAISFhqaCCLPGVIPYslayaclkLVNYSFFF 311
Cdd:PRK09556  220 GWgkaEEIFGEPISEED--------KETESTDMTKWQIFV-EYVLKNPVIWL---LCFANIFLY--------IVRIGIDN 279
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 312 WLPFYLSNNFGWKEAEADKLSIWYDVGGIIGGTLLGFISDVLQ-KRAPVLALSLFLAVGSLVGYSRSPNNKSINALLMTI 390
Cdd:PRK09556  280 WSPVYAFQELGFSKEDAINTFTLFEIGALVGSLLWGWLSDLANgRRALVACIALALIIFTLGVYQHATSEYMYLASLFAL 359

                  ....*...
gi 1039775817 391 tGFFIGGP 398
Cdd:PRK09556  360 -GFLVFGP 366
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
84-227 2.38e-10

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 62.21  E-value: 2.38e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817  84 LGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWlhfynkWFYCGLWIVNGLLQSTGWPCVV 163
Cdd:cd17325   237 IGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSF------WLLLLLLALLGLGLGLVFPATL 310
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039775817 164 AVMGNWFGKAGRGVVFGLWSACASVGNILGAFLASSVLQ-YGYEYAFLVTASVQFAGGIIIFFGL 227
Cdd:cd17325   311 ALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDaFGFATPFLAAAALLLLAAVLFLLLR 375
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
84-473 5.61e-09

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 57.94  E-value: 5.61e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817  84 LGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWLhfynkWFYCGLWIV---NGLLQSTGWP 160
Cdd:COG0738    45 AGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYP-----LLLLALFLLglgLGLLDVAANP 119
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 161 CVVAVmgnwfGKAGRGVVFGLWSACASVGNILGAFLASSVLQYGYE----YAFLVTASVQFAGGIIIFFgllvspeeIGL 236
Cdd:COG0738   120 YVAAL-----GPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSlswhLPYLILAVLLLLLALLFLR--------SKL 186
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 237 PSIGAEESSEEDSQRplidgaeneddyepnysiqedravvqvkaiSFHQACCLPGVIPYSLAYACLKLVNYSFFFWLPFY 316
Cdd:COG0738   187 PEIEEEEEEAAGSAA------------------------------SLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLY 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 317 LSNNFGWKEAEADKLSIWYDVGGIIGGTLLGFISDVLqKRAPVLALSLFLAVGSLVGYSRSPNNkSINALLMTITGFFIg 396
Cdd:COG0738   237 LKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRF-GPVRLLRLSALLAAVGLLLALLAPGP-WLALIGLALVGLGL- 313
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039775817 397 gpSNMVSSAISAdlgrqeLIQGNSEALATVTGIVDGTGSIGAAVGQYLVSLIQDNLGWMWVFYFFILMTSCTILFIL 473
Cdd:COG0738   314 --SLMFPTIFSL------ALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLAL 382
2A0114 TIGR00893
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ...
84-473 1.81e-07

D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273326 [Multi-domain]  Cd Length: 399  Bit Score: 53.11  E-value: 1.81e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817  84 LGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWLHFYnkwfycGLWIVNGLLQSTGWPCVV 163
Cdd:TIGR00893  31 YGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAGAYVSLY------ILRVLLGAAEAPFFPGII 104
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 164 AVMGNWFGKAGRGVVFGLWSACASVGNILGAFLASSVLQ-YGYEYAFLVTASVQFAGGIIIFFGLLVSPEEIGLpsigae 242
Cdd:TIGR00893 105 LIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIhFSWQWAFIIEGVLGIIWGVLWLKFIPDPPQKAKW------ 178
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 243 ESSEEDSqrpLIDGAENEDdyepnysiQEDRAVVQVKAISFHQACCLPGVIPYSLAYACLKLVNYSFFFWLPFYLSNNFG 322
Cdd:TIGR00893 179 LTEEEKY---IVVGGLLAE--------QQGKGPSTPKKYQIKELLKDRRVWGLALGQFLVNIGLGFFLTWFPTYLVQERG 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 323 WKEAEADKLSIWYDVGGIIGGTLLGFISDVLQKRAPVLALSLFLA-----VGSLVGYSRSPNNKSINALLMTITGFFIGG 397
Cdd:TIGR00893 248 LSILEAGFMASLPGIVGFIGMILGGRLSDLLLRRGKSLVFARKTAiiaglVLSLLMFATNYVNIPYAALALVALGFFGLG 327
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 398 PSNMVSSAISADLGRqeliqgnsEALATVTGIVDGTGSIGAAVGQYLVSLIQDNLG-WMWVFYF---FILMTSCTILFIL 473
Cdd:TIGR00893 328 AGAIGWALISDNAPG--------NIAGLTGGLINSLGNLGGIVGPIVIGAIAATTGsFAGALMVvaaLALIGALSYLLLV 399
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
84-453 7.77e-07

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 51.47  E-value: 7.77e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817  84 LGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWlhfynkWFYCGLWIVNGLLQSTGWPCVV 163
Cdd:cd17328    36 AGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNF------WQLLLFRALVGIGEASYSPIAP 109
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 164 AVMGNWFGKAGRGVVFGLWSACASVGNILGAFLASSV--LQYGYEYAFLVTASVQFAGGIIIFFGLlvspeeiglpsiga 241
Cdd:cd17328   110 TIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVaqATGGWRWAFRVTGVLGVLLAILLLLFV-------------- 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 242 eesseEDSQRPLIDGAENEDDYEPNYsIQEDRAVVQVKAISFHqacclpgvipySLAYACLKLVNYSFFFWLPFYLSNNF 321
Cdd:cd17328   176 -----REPPRGAAEGGVMAKSTATSF-LADLKALAKNPSFILS-----------TLGFTAVSFVTGALAFWAPTFFLRAF 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 322 GWKEAEADKLSIWYDVGGIIG----GTLLGFISDVLQKRAP-----VLALSLFLAVGSLVGysrSPNNKSINALLMTITG 392
Cdd:cd17328   239 GVGDLSSADVGLIFGAITCIAgvlgVLLGGILADRLRRKTPradplVCAVGLLAAAPFLFL---ALVLALSNLLLAWVLL 315
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039775817 393 FFIGGPSNMVSSAISADLgrQELIQGNSEALATVTGIVdGTGSIGAAVGQYLVSLIQDNLG 453
Cdd:cd17328   316 FLGEFLLSLNWAPVFAIL--LYVVIPTRRSTASAIQIL-LSHLLGDAGSPYLIGLISDLLR 373
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
84-473 1.85e-06

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 50.26  E-value: 1.85e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817  84 LGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWLHFYnkwfycGLWIVNGLLQSTGWPCVV 163
Cdd:COG2807    55 AGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLL------AGTALIGAGIAVGNVLLP 128
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 164 AVMGNWFGKAgRGVVFGLWSACASVGNILGAFLASSVLQ-YGYEYAFLVTASVQFAGGIIIFFGLLVSPEeiglpsiGAE 242
Cdd:COG2807   129 GLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAaLGWRGALAVWALLALLALLLWLPLLRRRPA-------AAA 200
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 243 ESSEEDSQRPLIdgaeneddyepnysiqEDRAVVQVkaisfhqacclpgvipySLAYACLKLVNYSFFFWLPFYLSNNfG 322
Cdd:COG2807   201 AAPAAASLRSLW----------------RSPLAWLL-----------------TLFFGLQSLLYYAVVAWLPPILRDA-G 246
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 323 WKEAEADKLSIWYDVGGIIGGTLLGFISDVLQKRAPVLALSLFLAVGSLVGYSRSPNnkSINALLMTITGFFIGGPSNMV 402
Cdd:COG2807   247 LSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPG--SLPWLWAVLLGLGQGGLFPLA 324
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039775817 403 SSAISadlgrqeLIQGNSEALATVTGIVDGTGSIGAAVGQYLVSLIQDNLG-WMWVFYFFILMTSCTILFIL 473
Cdd:COG2807   325 LTLIG-------LRARTPAEAAALSGMAQSVGYLLAALGPLLVGALHDATGsWTAALLLLAALAVLMLVAGL 389
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
85-227 1.94e-06

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 49.92  E-value: 1.94e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817  85 GTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWlhfynkWFYCGLWIVNGLLQSTGWPCVVA 164
Cdd:cd17329    38 GLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSP------WLFAIALVLTGFGGGLFEPASEA 111
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039775817 165 VMGNWFGKAGRGVVFGLWSACASVGNILGAFLASSVLQYGYEYAFLVTASVQFAGGIIIFFGL 227
Cdd:cd17329   112 MIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAALVLLFLL 174
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
81-224 2.55e-06

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 49.48  E-value: 2.55e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817  81 TLFLGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFgtltewLHFYNKWFYCGLWIVNGLLQSTGWP 160
Cdd:cd17478   229 LVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLF------LLTPGIWSYILLVLAGFLLFASFPV 302
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039775817 161 CVVAVMGNWFGKAG--RGVVFGLwsaCASVGNILGAFLASSVLQYGYEYAFLVTASVQFAGGIIIF 224
Cdd:cd17478   303 TVVLAQELLPGNVGlaSGLMMGL---SFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
84-473 7.29e-06

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 48.09  E-value: 7.29e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817  84 LGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWLHFYNKWFYCGLwiVNGLLQSTGWPCVV 163
Cdd:cd17333    33 VSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGL--GAGILDTGANTFVG 110
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 164 AVMGNWFGKAgRGVVFGLWSACASVGNILGAFLASSVLqyGYEYAFLVTASVQFAGGIIIFFGLLvspeeiglpsigaee 243
Cdd:cd17333   111 ALFEESSATR-LNVLHGFFGLGALIGPLIATSLLTSEL--SWSWAYLIIGLIYLLLAILILLTLF--------------- 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 244 sseedsqrplidgAENEDDYEPNYSIQEDRAVVQVKAISfhqacclPGVIPYSLAYACLKLVNYSFFFWLPFYLSNNFGW 323
Cdd:cd17333   173 -------------PELPSARNPQQSVGAFSASASRLLRN-------PSIILGALALFLYVGAETAFSSWVPSYLVEKKHV 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 324 KEAEADKLSIWYDVGGIIGGTLLGFISDVLQKRApVLALSLFLAVGSLVGYSRSPnNKSINALLMTITGFFIGGpsnMVS 403
Cdd:cd17333   233 SDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHT-LLVLSGSGALLGLLILLLAP-TLVVGLVATALLGLFMAA---LFP 307
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 404 SAISadlgrqELIQGNSEALATVTGIVDGTGSIGAAVGQYLVSLIQDNLGWMWVFYFFILMtsCTILFIL 473
Cdd:cd17333   308 TILS------LGISNLPYAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITIL--YAIIFVL 369
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
76-225 1.45e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 47.20  E-value: 1.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817  76 STEEATLFLGtldtVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGtlteWLHFYNKWFYCGLWIVNGLLQ 155
Cdd:COG2211   262 SAALVGLLLA----LYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLF----FLGPGNLWLLLVLAALAGIGL 333
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039775817 156 STGWPCVVAVM------GNW-FGKAGRGVVFGLWSACASVGNILGAFLASSVLQ-YGYEYAFLVTASVQFAGGIIIFF 225
Cdd:COG2211   334 GAILVLPWAMLadvvdyDEWkTGRRREGLYFGIFTFAIKLGQALAGALAGLLLAlFGYVAGAAQSPSALTGIRLLFFL 411
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
84-241 1.86e-05

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 46.34  E-value: 1.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817  84 LGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMcssafVVFVFGTL-------TEWLhfynkwfyCGLWIVNGLLQS 156
Cdd:COG0477    51 LGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGL-----LLFGLASLlcglapsPELL--------IAARALQGIGAG 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 157 TGWPCVVAVMGNWFGKAGRGVVFGLWSACASVGNILGAFLASSVLQY-GYEYAFLVTASVqfagGIIIFFGLLVSPEEIG 235
Cdd:COG0477   118 GLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAAlGWRWIFLINAPL----GLLALVLRLRLPESRG 193

                  ....*.
gi 1039775817 236 LPSIGA 241
Cdd:COG0477   194 LLLALL 199
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
25-215 2.19e-05

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 46.84  E-value: 2.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817  25 LLTFFSYSLLHASRKTFSNVKVSISKQWTPNAFNTSLDLPAEIWSSNHLFP-STEEATLFLGTldtvFLFSYAVGLFISG 103
Cdd:cd17318     2 ILLFLGFAVVYAMRVNLSVAIVAMVNSTATHDNNNTSTDKDTLPVEAPEFDwSEKTQGIILSS----FFYGYILTQIPGG 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 104 IIGDRLNLRWVLSFGMCSSAFVVFvfgtLTEWLHFYNKWFYCGLWIVNGLLQSTGWPCVVAVMGNWFGKAGRGVVFGLWS 183
Cdd:cd17318    78 YLAEKYGAKRVLGYSILITALLTL----LTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAY 153
                         170       180       190
                  ....*....|....*....|....*....|....
gi 1039775817 184 ACASVGNILgAFLASSVL--QYGYEYAFLVTASV 215
Cdd:cd17318   154 SGSQFGTVI-AMPLSGFLceSLGWPSIFYIFGGL 186
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
9-230 3.89e-05

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 46.00  E-value: 3.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817   9 RGALLTSFSHHHLAVFLLTFFSYSLlhasrktfsnVKVSISkQWTPNAFNTSLDLPAEIwssnhlfpsteeATLFLgtld 88
Cdd:COG0738   200 AASLKSLLKNPRLLLGGLAIFLYVG----------AEGAIG-DWLPLYLKDVLGLSEAT------------AALGL---- 252
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817  89 TVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTewlhfyNKWFYCGLWIVNGLLQSTGWPCVVAVMGN 168
Cdd:COG0738   253 SLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAP------GPWLALIGLALVGLGLSLMFPTIFSLALD 326
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039775817 169 WFGKAGrGVVFGLWSACASVGNILGAFLASSVLQ-YGYEYAFLVTAsvqFAGGIIIFFGLLVS 230
Cdd:COG0738   327 GLGKRT-AAAVSAVLIMGIVGGAIGPPLIGFLADaFGLRAAFLVPL---VCYLLILLLALALK 385
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
89-453 7.65e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 44.89  E-value: 7.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817  89 TVFLFSYAVGLF---ISGIIGDRLNLRW-----VLSFGMCSSAFVVFVFGTLTEWLHFYNKWFYCGLWIVNGLLQSTGWP 160
Cdd:COG2211    50 LILLVARLWDAItdpLIGALSDRTRTRWgrrrpWILIGAIPLALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVNI 129
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 161 CVVAVMGNWFGKAG-RGVVFGLWSACASVGNILGAFLASSVLQY-------GYEYAFLVTASVQFAGGIIIFFGLlvspe 232
Cdd:COG2211   130 PYSALGAELTPDYEeRTRLSSWRFAFAGLGGLLASVLPPPLVAAfggdaalGYRLTALIFAVLGLLAFLLTFFGT----- 204
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 233 eiglpsigAEESSEEDSQRPLIDGAeneddyepnysiqedRAVVQVKAISFHqacclpgvipySLAYACLKLVNYSFFFW 312
Cdd:COG2211   205 --------KERPVPEEEKVSLKESL---------------KALLKNRPFLLL-----------LLAYLLFFLALALVAAL 250
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 313 LPFYLSNNFGWKEAEADKLSIWYDVGGIIGGTLLGFISDVLQKRAPVLALSLFLAVGSLVGYSRSPNNKSINALLMTITG 392
Cdd:COG2211   251 LLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAG 330
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039775817 393 FFIGGPsNMVSSAISADLGRQELIQGNSEALATVTGIVDGTGSIGAAVGQYLVSLIQDNLG 453
Cdd:COG2211   331 IGLGAI-LVLPWAMLADVVDYDEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFG 390
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
85-473 8.63e-05

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 44.85  E-value: 8.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817  85 GTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMcssafVVFVFGTLTEWLHfYNKWFYCGLWIVNGLLQSTGWPCVVA 164
Cdd:cd17324    37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLL-----LLFILGNLLAALA-PSFALLLLARALAGLAHGGFWAIAAA 110
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 165 VMGNWFGKAGRGVVFGLWSACASVGNILGAFLASSVLQY-GYEYAFLVTASVQFAGGIIIFFgllvspeeiGLPSIGAEE 243
Cdd:cd17324   111 YAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLlGWRAAFLAIAVLALLAALLLWR---------LLPSLPPKK 181
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 244 SSEEDSQRPLIDGAENeddyepnysiqedravvqvkaisfhqacclPGVIPYSLAYACLKLVNYSFFFWLPFYLSNNFGW 323
Cdd:cd17324   182 PGSLGLLSSLLLLLRN------------------------------PRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGF 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 324 KEAEADKLSIWYDVGGIIGGTLLGFISDVLQKRAPVLALSLFLAVGSLVGYsrSPNNKSINALLMTITGFFIGGPSNMVS 403
Cdd:cd17324   232 SSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTL--LGPSPLLLLVGLVLWGLGFFAAHSALQ 309
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 404 SAISadlgrqeliQGNSEALATVTGIVDGTGSIGAAVGQYLVSLIQDNLGWMWVFYFFILMTSCTILFIL 473
Cdd:cd17324   310 TRVL---------RLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
84-225 2.09e-04

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 43.37  E-value: 2.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817  84 LGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWlhfynkWFYCGLWIVNGLLQSTGWPCVV 163
Cdd:cd06173   246 YGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSL------WLLLAALFLLGLAGGLFNVPLN 319
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039775817 164 AVMGNWFGKAGRGVVFGLWSACASVGNILGAFLASSVLQ-YGYEYAFLVTASVQFAGGIIIFF 225
Cdd:cd06173   320 TLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADaLGLSAVFLLAGALLLLAALLLLL 382
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
84-246 2.21e-04

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 43.38  E-value: 2.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817  84 LGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFvfgtLTEWLHFYnkWFYCGLWIVNGLLQSTGWPCVV 163
Cdd:cd17475    33 VGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAAL----LMALVGSY--PVLLVLLFLVGAGYGSVQPGGG 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 164 -AVMGnWFGKAGRGVVFGLWSACASVGNILGA-FLASSVLQYGYEYAFLVTASVQFAGGIIIFFGLLVSPEEIGLPSIGA 241
Cdd:cd17475   107 rAIMR-WFPPRERGLAMGIRQTGVPLGGALAAaLLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPPAASAATESAS 185

                  ....*
gi 1039775817 242 EESSE 246
Cdd:cd17475   186 TLLRS 190
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
25-214 2.55e-04

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 43.31  E-value: 2.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817  25 LLTFFSYSLLHASRKTFSNVKVSISKQwtpnaFNtsldlpaeiWSSNhlfpsteeatlFLGTLDTVFLFSYAVGLFISGI 104
Cdd:cd17380     2 ILLFLATCICYADRVNMPIAIVPMAKE-----FG---------WSKT-----------DQGLVLSSFFWGYALTQVLGGY 56
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 105 IGDRLNLRWVLSFGMCSSAFVVFvfgtLTEWLHFYNKWFYCGLWIVNGLLQSTGWPCVVAVMGNWFGKAGRGVVFGLWSA 184
Cdd:cd17380    57 LADRFGGKKVLLLAVALWSLATL----LTPLLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTA 132
                         170       180       190
                  ....*....|....*....|....*....|.
gi 1039775817 185 CASVGNILGAFLASSVL-QYGYEYAFLVTAS 214
Cdd:cd17380   133 GSYLGTLLGGLIGPLLLeYYGWPSVFYFFGL 163
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
89-251 3.68e-04

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 42.60  E-value: 3.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817  89 TVFLFSYAVGLFISGIIGDRLNLRWVLSFG--MCSSAFVVFVFGTltewlhfYNKWFYCGLWIVNGLLQSTGWPCVVAVM 166
Cdd:cd17353    45 TLTIVFLAISAPFAGRLVDRGGPRKAILIGgiLFGLGFILSAFAI-------SLPLLFLGYGVLGGIGAGIGYITPVSTA 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 167 GNWFgKAGRGVVFGLWSACASVGNILGAFLASSVL-QYGYEYAFLVTASVQFAGGIIIFFGLLVSPEEIGLPSIGAEESS 245
Cdd:cd17353   118 VKWF-PDKRGLATGIVIAGFGLGSLIFSPLIAYLInTVGVPTTFLILGIIFLIIIVIGAFLIRDPPKGWVPPGVDPLANN 196

                  ....*.
gi 1039775817 246 EEDSQR 251
Cdd:cd17353   197 AENSPR 202
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
89-224 7.33e-04

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 41.76  E-value: 7.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817  89 TVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWLHFynkWFYCGLW-IVNGLLQSTGwPCVVAVMG 167
Cdd:cd17370   241 ALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLL---LLGFILWgLYMGAQESIE-RAAVADLV 316
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1039775817 168 nwfGKAGRGVVFGLWSACASVGNILGAFLASSVLQ-YGYEYAFLVTASVQFAGGIIIF 224
Cdd:cd17370   317 ---PAELRGTAYGLFNTVVGIGWLLASLIAGYLWDlISPSAAFLFSAVLALIALLLLL 371
TRI12 pfam06609
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ...
349-473 1.03e-03

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.


Pssm-ID: 115279 [Multi-domain]  Cd Length: 598  Bit Score: 41.58  E-value: 1.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 349 ISDVLQKRAPVLALSLFLAVGSLVGYSRSPNNKSINAllMTITGFfIGGPSNmvssaiSADLGRQELIQGNSE--ALATV 426
Cdd:pfam06609 101 LTDRFGRRPFVIATHIIGLVGAIVGCTANKFNTLLAA--MTLLGV-AAGPAG------ASPLFIGELMSNKTKflGLLIV 171
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1039775817 427 TGIVDGTGSIGAAVGQYLVslIQDNlgWMWVFYFFILMTSCTILFIL 473
Cdd:pfam06609 172 SAPTIAMNGAGPYFGQRLA--IQGN--WRWIFYIYIIMSAIAVLLII 214
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
100-225 2.35e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 40.27  E-value: 2.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 100 FISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWLHFYnkwfycGLWIVNGLLQSTGWPCVVAVMGNWFGKAGRGVVF 179
Cdd:cd17489   245 PFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLL------LAAVLYGLGFGLLFPALQALAVDLVPPHRRGAAN 318
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1039775817 180 GLWSACASVGNILGAFLASSVLQY-GYEYAFLVTASVQFAGGIIIFF 225
Cdd:cd17489   319 GTFFIFFDLGIGLGGLLLGLVAELfGYRAMFLLAAVVVLLALVLYIF 365
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
160-227 3.52e-03

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 39.56  E-value: 3.52e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039775817 160 PCVVAVMGNWFGKAGRGVVFGLWSACASVGNILGAFLASSV-LQYGYEYAFLVTASVQFAGGIIIFFGL 227
Cdd:cd17391   312 PAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIaAHFGYRAVFVVTALLVLLNAIWSFIFL 380
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
82-225 4.17e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 39.52  E-value: 4.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817  82 LFLGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTeWLHFYNKWFYCGLWIVNGLLQSTGWPC 161
Cdd:cd06173    34 LLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLA-LLGSLSLWLLLVLAFLLGIASAFFGPA 112
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039775817 162 VVAVMGNWFGKAGRGVVFGLWSACASVGNILGAFLASSVLQ-YGYEYAFLVTASVQFAGGIIIFF 225
Cdd:cd06173   113 RQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVAlLGPGGAFAINALSFLLSALLLLF 177
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
85-225 4.95e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 39.11  E-value: 4.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817  85 GTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWlhfynkWFYCGLWIVNGLLQSTGWPCVVA 164
Cdd:cd17489    34 GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSV------ALLLVLRLIHGIGWGAFTTAAAT 107
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039775817 165 VMGNWFGKAGRGVVFGLWSACASVGNILGAFLASSVLQ-YGYEYAFLVTASVQFAGGIIIFF 225
Cdd:cd17489   108 LVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQhLGFAVLFIVAAVLALLALLLVFL 169
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
80-473 8.50e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 38.35  E-value: 8.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817  80 ATLFLGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWlhfynkWFYCGLWIVNGLLQSTGW 159
Cdd:cd17316    34 SLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTP------ILLLVLRFLQGIGIGGEY 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 160 PCVVAVMGNWFGKAGRGVVFGLWSACASVGNILGAFLASSV-----LQYGYEYAFLVtasvqfaGGIIIFFGLLVSpeei 234
Cdd:cd17316   108 PGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLipllsGDWGWRILFLI-------GALPALLALLLR---- 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 235 glpsigaeesseedsqrplidgaeneddyepnysiqedRAVVQVkaisfhqacclpgvipySLAYACLKLVNYSFFFWLP 314
Cdd:cd17316   177 --------------------------------------RRTLLL-----------------ILLWFFISFGYYGLTTFLP 201
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817 315 FYLSNNFGWKEAEADKLSIWYDVGGIIGGTLLGFISDVLQKRaPVLALSLFLAVGSLVGYSRSPNNKSINALLMTITGFF 394
Cdd:cd17316   202 TYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRK-KTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSF 280
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039775817 395 IGGPSNMVSSAISADLGRqeliqgnSEALATVTGIVDGTGSIGAAVGQYLVSLIQDNLGWMWVFYFFILMTSCTILFIL 473
Cdd:cd17316   281 FVGGVWGALYAYLAELFP-------TEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVA 352
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
89-197 8.53e-03

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 38.46  E-value: 8.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775817  89 TVFLFSYAVGLFISGIIGDRLNLRWVLSFgmcsSAFVVFVFGTLTEWLHFYnkWFYCGLWIVNGLLQSTGWPCVVAVMGN 168
Cdd:TIGR00898 134 SCFFVGVLLGSFVFGYLSDRFGRKKVLLL----STLVTAVSGVLTAFSPNY--TVFLVFRLLVGMGIGGIWVQAVVLNTE 207
                          90       100
                  ....*....|....*....|....*....
gi 1039775817 169 WFGKAGRGVVFGLWSACASVGNILGAFLA 197
Cdd:TIGR00898 208 FLPKKQRAIVGTLIQVFFSLGLVLLPLVA 236
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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