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Conserved domains on  [gi|1207168917|ref|XP_021326702|]
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G patch domain-containing protein 8 isoform X2 [Danio rerio]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 10573383)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0003677|GO:0008270|GO:0003700
PubMed:  11179890|12665246|11361095|10940247
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 58-85 3.32e-05

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


:

Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 41.77  E-value: 3.32e-05
                           10        20
                   ....*....|....*....|....*...
gi 1207168917   58 FYCELCDKQYQKHQEFDNHINSydHAHK 85
Cdd:pfam12171    2 FYCVLCDKYFKSENALQNHLKS--KKHK 27
PRK03918 super family cl35229
DNA double-strand break repair ATPase Rad50;
4-126 4.97e-03

DNA double-strand break repair ATPase Rad50;


The actual alignment was detected with superfamily member PRK03918:

Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 41.59  E-value: 4.97e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207168917    4 GRMEMELDYAEDATEkrrvlEVEKEdTEELRQKYKDFAEKEKAIAKALEDLR-ANFYCELCDKQYQKHQEfDNHINSYDH 82
Cdd:PRK03918   387 EKLEKELEELEKAKE-----EIEEE-ISKITARIGELKKEIKELKKAIEELKkAKGKCPVCGRELTEEHR-KELLEEYTA 459

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1207168917   83 AHKQRLKELK----QREFARNVSSRSRKDGKKQEKmLRRLHELAEQRK 126
Cdd:PRK03918   460 ELKRIEKELKeieeKERKLRKELRELEKVLKKESE-LIKLKELAEQLK 506
 
Name Accession Description Interval E-value
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 58-85 3.32e-05

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 41.77  E-value: 3.32e-05
                           10        20
                   ....*....|....*....|....*...
gi 1207168917   58 FYCELCDKQYQKHQEFDNHINSydHAHK 85
Cdd:pfam12171    2 FYCVLCDKYFKSENALQNHLKS--KKHK 27
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
4-126 4.97e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 41.59  E-value: 4.97e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207168917    4 GRMEMELDYAEDATEkrrvlEVEKEdTEELRQKYKDFAEKEKAIAKALEDLR-ANFYCELCDKQYQKHQEfDNHINSYDH 82
Cdd:PRK03918   387 EKLEKELEELEKAKE-----EIEEE-ISKITARIGELKKEIKELKKAIEELKkAKGKCPVCGRELTEEHR-KELLEEYTA 459

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1207168917   83 AHKQRLKELK----QREFARNVSSRSRKDGKKQEKmLRRLHELAEQRK 126
Cdd:PRK03918   460 ELKRIEKELKeieeKERKLRKELRELEKVLKKESE-LIKLKELAEQLK 506
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 57-91 5.53e-03

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 35.69  E-value: 5.53e-03
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 1207168917    57 NFYCELCDKQYQKHQEFDNHINSydHAHKQRLKEL 91
Cdd:smart00451    3 GFYCKLCNVTFTDEISVEAHLKG--KKHKKNVKKR 35
 
Name Accession Description Interval E-value
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 58-85 3.32e-05

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 41.77  E-value: 3.32e-05
                           10        20
                   ....*....|....*....|....*...
gi 1207168917   58 FYCELCDKQYQKHQEFDNHINSydHAHK 85
Cdd:pfam12171    2 FYCVLCDKYFKSENALQNHLKS--KKHK 27
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
4-126 4.97e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 41.59  E-value: 4.97e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207168917    4 GRMEMELDYAEDATEkrrvlEVEKEdTEELRQKYKDFAEKEKAIAKALEDLR-ANFYCELCDKQYQKHQEfDNHINSYDH 82
Cdd:PRK03918   387 EKLEKELEELEKAKE-----EIEEE-ISKITARIGELKKEIKELKKAIEELKkAKGKCPVCGRELTEEHR-KELLEEYTA 459

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1207168917   83 AHKQRLKELK----QREFARNVSSRSRKDGKKQEKmLRRLHELAEQRK 126
Cdd:PRK03918   460 ELKRIEKELKeieeKERKLRKELRELEKVLKKESE-LIKLKELAEQLK 506
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 57-91 5.53e-03

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 35.69  E-value: 5.53e-03
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 1207168917    57 NFYCELCDKQYQKHQEFDNHINSydHAHKQRLKEL 91
Cdd:smart00451    3 GFYCKLCNVTFTDEISVEAHLKG--KKHKKNVKKR 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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