BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental process. It may also act as a protein-protein adaptor in a transcription complex and thus may be involved in brain development.

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1344765271 1253 CTAGVLECFPLSSVYGLDDLYRKCLRWITKYFAKVWPTKAFATLPKELLDKCYQEHIVNLSIEN 1316
Cdd:cd18490      1 CLAGVLECLPLAHTFGLEDLYEKCLRWIAKHFAKVWSTKSFASLPPELQEKCYEALVSSLTIEN 64

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental process. It may also act as a protein-protein adaptor in a transcription complex and thus may be involved in brain development.

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1344765271 1253 CTAGVLECFPLSSVYGLDDLYRKCLRWITKYFAKVWPTKAFATLPKELLDKCYQEHIVNLSIEN 1316
Cdd:cd18490      1 CLAGVLECLPLAHTFGLEDLYEKCLRWIAKHFAKVWSTKSFASLPPELQEKCYEALVSSLTIEN 64

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344765271 1134 LLRMFLEEIAPDVIVEASGKRIKAHKCILSSRCQYFAGILSGGWVESAGNVIVLPPFSFEVVHFALCHIYSGlsTIPDSI 1213
Cdd:pfam00651    1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTG--KLISEE 78

                           90       100
                   ....*....|....*....|....*...
gi 1344765271 1214 SIVELATIADMLSLEGLKEAIMFTLKAK 1241
Cdd:pfam00651   79 NVDDLLAAADKLQIPSLVDKCEEFLIKS 106

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental process. It may also act as a protein-protein adaptor in a transcription complex and thus may be involved in brain development.

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1344765271 1253 CTAGVLECFPLSSVYGLDDLYRKCLRWITKYFAKVWPTKAFATLPKELLDKCYQEHIVNLSIEN 1316
Cdd:cd18490      1 CLAGVLECLPLAHTFGLEDLYEKCLRWIAKHFAKVWSTKSFASLPPELQEKCYEALVSSLTIEN 64

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344765271  1145 DVIVEASGKRIKAHKCILSSRCQYFAGILSGGWVESAGNVIVLPPFSFEVVHFALCHIYSGlSTIPDSISIVELATIADM 1224
Cdd:smart00225    1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTG-KLDLPEENVEELLELADY 79

                            90
                    ....*....|....*
gi 1344765271  1225 LSLEGLKEAIMFTLK 1239
Cdd:smart00225   80 LQIPGLVELCEEFLL 94

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344765271 1145 DVIVEASGKRIKAHKCILSSRCQYFAGILSGGWVESAGNVIVLPPFSFEVVHFALCHIYSGLSTIPDSISIVELATIADM 1224
Cdd:cd18300     11 DVTFIVEDGTIPAHKALLVARCDVMAAMFGGNFRESSAKEVELPGVSKETFLALLEYLYTDQAPILEDGDCVGLIVLANR 90

                   ....*...
gi 1344765271 1225 LSLEGLKE 1232
Cdd:cd18300     91 LCLPRLVA 98

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344765271 1128 SRLGQDLLRMFLEEIAPDV--IVEasGKRIKAHKCILSSRCQYFAGILSGGWVESAGNVIVLPPFSFEVVHFALCHIYSG 1205
Cdd:cd18287      7 HFLSEDIGALFLNEEYSDVtfVVE--EKRFPAHRVILAARSEYFRALLYGGMRESQQSEIELKDTNAEAFKALLKYIYTG 84

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1344765271 1206 LSTIPDsisiVELATIADMLSL------EGLKEAI 1234
Cdd:cd18287     85 RLTLTD----LKEDVLLDVLGLahqygfEELEAAI 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344765271 1132 QDLLRMFLEEIAPDVIVEASGKRIKAHKCILSSRCQYFAGILSGGWVESAGNVIVLPPFSFEVVHFALCHIYSGLSTIPD 1211
Cdd:cd18298      1 DSLRKAFNDPRTSDLKFRVDGKYIYVHKAILKIRCEYFRSMFQSHWNEDDKNVIEIDQYSYPVYYAFLRYLYTDQVDLPP 80

                           90       100
                   ....*....|....*....|.
gi 1344765271 1212 sISIVELATIADMLSLEGLKE 1232
Cdd:cd18298     81 -EDAIGLLDLANSYCEERLKK 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1); RCBTB1 is also called chronic lymphocytic leukemia deletion region gene 7 protein (CLLD7), CLL deletion region gene 7 protein, regulator of chromosome condensation and BTB domain-containing protein 1, or E4.5. It is a novel chromosome condensation regulator-like guanine nucleotide exchange factor that may be involved in cell cycle regulation by chromatin remodeling. It may also function as a tumor suppressor that regulates pathways of DNA damage/repair and apoptosis. RCBTB1 may also be a substrate adaptor for a cullin3 (CUL3) E3 ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Biallelic mutations in RCBTB1 may cause isolated and syndromic retinal dystrophy. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344765271 1130 LGQDLLRMFLEEIAPDVIVEASGKRIKAHKCILSSRCQYFAGILSGGWVESAGNVIVLPPFSFEVVHFALCHIYSGLSTI 1209
Cdd:cd18353      7 VAESLKKEFDSPETSDLKFRVDGKYIHVHKAVLKIRCEHFRTMFQSHWNEDMKEVIEIDQFSYPVYRAFLEYLYTDSVDL 86

                           90
                   ....*....|...
gi 1344765271 1210 P--DSISIVELAT 1220
Cdd:cd18353     87 PpeDAIGLLDLAT 99

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1344765271 1132 QDLLRMFLEEIAPDVIVEASGKRIKAHKCILSSRCQYFAGILSGGWVESAGNVIVLPPFSFEVVHFALCHIYSG 1205
Cdd:cd18263      2 QSIEGLWEKGVGCDVQLEADGSIFRVHRVILAAGSDYFRAMFTSGMKESTQSVVQLPTIPAKDLRLLISFAYSG 75

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344765271 1136 RMFLEEIAPDVIVEASGKRIKAHKCILSsRCQYFAGILSGGWVESAGNVIVL----PPFSFEVVHFALCHIYSGLSTIPD 1211
Cdd:cd18305      8 TLFLNGENSDITICALGREWKLHKIYLC-QSGYFASMFSGSWKESKETVINLeipdDNITVEALNVVFGSLYRDEIEIKP 86

                           90       100
                   ....*....|....*....|.
gi 1344765271 1212 S--ISIVELATiadMLSLEGL 1230
Cdd:cd18305     87 SrvVSILAAAT---LLQLDGL 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344765271 1145 DVIVEASGKRIKAHKCILSSRCQYFAGILSGGWVESAGNVIVLPPFSFEVVHFALCHIYSGLSTIPDSiSIVELATIADM 1224
Cdd:cd18256     22 DVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHGVEPDIFHILLDFIYTGVVEVTVS-NVQELLVAADM 100

                   ....*....
gi 1344765271 1225 LSLEGLKEA 1233
Cdd:cd18256    101 LQLTEVVEI 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344765271 1144 PDVIVEASGKRIKAHKCILSSRCQYFAGILSGGWVESAGnvivlppFSFEVVHFALCHIYSG-LSTIPDsiSIVELATIA 1222
Cdd:cd18275      5 PDLVIEVSGQRIRAHKSVLAAKSDYFRARLSRDILKVKG-------LSYATLRLLVDYVYSGrMAVSKD--NVVEVVAGA 75

                           90       100
                   ....*....|....*....|...
gi 1344765271 1223 DMLSLEGLKEAIMFTLKAKYCHH 1245
Cdd:cd18275     76 RFLQMPCAAQCAVDAVRAQLCLG 98

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344765271 1130 LGQDLLRMFLEEIAPDVIVEASGKRIKAHKCILSSRCQYFAGILSGGWVESAGNVIVL----PPFSFEVVHF-------- 1197
Cdd:cd18280      1 LGQHFGALLESEEGADVTFNVDGEKFRAHKLVLAARSPVFRSMLFGPMREENEGEIVIedvePPVFKALLHFiykdelpd 80

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1344765271 1198 ALCHIYSGLSTIPDSIsIVELATIADMLSLEGLK 1231
Cdd:cd18280     81 DVEPAGSDSSSLDTTM-AQHLLAAADRYALERLR 113

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344765271 1145 DVIVEASGKRIKAHKCILSSRCQYFAGILSGGWVESAGNVIVLPPFSFEVVHFALCHIYSGLSTIPDSISiVELATIADM 1224
Cdd:cd18352     15 DVTFLVEGRRFYAHRIALLASSDAFRAMFDGGYREKEARDIEIPNIRWEVFELMMRFIYTGSVDITNDIA-KDLLRAADQ 93

                           90
                   ....*....|....*....
gi 1344765271 1225 LSLEGLKEAIMFTLKAKYC 1243
Cdd:cd18352     94 YLLEGLKRLCEYTIAQDLT 112

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1344765271 1145 DVIVEASGKRIKAHKCILSSRCQYFAGILSGGWVESAGNVIVlPPFSFEVVHF-----ALCHIYSG 1205
Cdd:cd18301     20 DVVFQVGGKTFPAHKFILASRSDYFRKLFLSSLLTSEDAVGC-DVVHIEKVPPeifeqLLQFIYTD 84

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1344765271 1257 VLECFPLSSVYGLDDLYRKCLRWITKYFAKVWPTKAFATLPKELL 1301
Cdd:cd14733      5 CLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELL 49

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1); RhoBTB1 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB1 functions as a tumor suppressor that regulates the integrity of the Golgi complex through the methyltransferase METTL7B. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344765271 1145 DVIVEASGKRIKAHKCILSSRCQYFAGILSGGWVESAGNVIVLPPFSFEVVHFALCHIYSGLSTIPDSISIVELATIADM 1224
Cdd:cd18358     22 DVTFKLDDGTINAHKPLLICSCEWMAAMFGGSFIESANSEVVLPNISKVSMQAVLDYLYTKQLSPTADLDPLELIALANR 101

                   ....*.
gi 1344765271 1225 LSLEGL 1230
Cdd:cd18358    102 FCLPHL 107

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344765271 1145 DVIVEASGKRIKAHKCILSSRCQYFAGILsGGWVESAGNVIVLPPFSFEVVHFALCHIYSGLSTIPDSIsIVELATIADM 1224
Cdd:cd18315      3 DVTLACEGGSLKAHKLVLAAASPYFAALL-KETPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQ-LESLLKLAEL 80

                   ....*
gi 1344765271 1225 LSLEG 1229
Cdd:cd18315     81 LQIKG 85

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344765271 1145 DVIVEASGKRIKAHKCILSSRCQYFAGILSGGWVESAGNVIVLPPFSFEVVHFALCHIYSGLSTIpdSISIVE-LATIAD 1223
Cdd:cd18250     23 DVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRESRADRVVLHGVSAEILGLLLDFSYTGRVTV--TQDNVEaLLRAAD 100

                           90
                   ....*....|
gi 1344765271 1224 MLSLEGLKEA 1233
Cdd:cd18250    101 LFQFPSVKEA 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344765271 1145 DVIVEASGKRIKAHKCILSSRCQYFAGILSGGWVESAGNVIVLPPFSFEVVHFALCHIYSGlsTIPDSISIV-ELATIAD 1223
Cdd:cd18242     23 DVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEVELQGLTASTMEILLDFVYTE--TVHVTVENVqELLPAAC 100

                           90
                   ....*....|
gi 1344765271 1224 MLSLEGLKEA 1233
Cdd:cd18242    101 LLQLKGVKQA 110

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1344765271 1129 RLGQDLLRMFLEEIAPDVIVEASGKRIKAHKCILSSR 1165
Cdd:cd18285      1 HLSQDLLRLLREELHTDVTFYVGSTLFKAHKAILLAR 37

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1344765271 1145 DVIVEASGKRIKAHKCILSSRCQYFAGILSGGWVESAGNVIVLPPFSFEVVHFALCHIYSG 1205
Cdd:cd18234      3 DVILIAGDRRIPAHRLVLSAVSDYFAAMFTNDVREATEEEIKLKDVDPDALWTLVQYCYTG 63

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1344765271 1146 VIVEASGKRIKAHKCILSSRCQYFAGILSGGWVESAGNVIVLPPFSFEVVHFALCHIYSGLSTIPDSI--SIVELA 1219
Cdd:cd01165      1 VVLVVEGEKFHVNKELLAQSSEYFRALFRGGFRESGQAEINLRDISPEDFRALLEFLYGGKRDLDASNllELLEAA 76

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344765271 1114 EETSQTSSLIGNCQSRLGQDLLRMFLEEIAPDVIVEASGKRIKAHKCILSSRCQYFAGILSGGWVESAGNVIVLPPFSFE 1193
Cdd:cd18273      5 EDAAHARALLAQLKSFYDARLLTDVTIEVNGPGSGPGSGRLFPCNRNVLAAASPYFKSMFTGGLYESKQETVTIHDVDSE 84

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1344765271 1194 VVHFALCHIYSGLSTIPDSiSIVELATIADMLSLEGLKEA 1233
Cdd:cd18273     85 SMALIIDYCYTGRVTLSEA-NVQRLYAAANMLQLEYVREA 123