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Conserved domains on  [gi|1720424137|ref|XP_030098843|]
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leucine-rich repeat-containing protein 56 isoform X3 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
8-121 3.09e-13

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.12  E-value: 3.09e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720424137   8 NSLGNfglyLPNLIQLKLNHSYLGSLRDLGTSLGHLQVLWLARCGLTDLDGIGSFLELKELYVSYNNISDLSPLCLLEQL 87
Cdd:COG4886   199 EPLGN----LTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNL 274

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1720424137  88 EVLDLEGNNVEDLgQMRYLQLCPRLAMLTLEGNL 121
Cdd:COG4886   275 KTLDLSNNQLTDL-KLKELELLLGLNSLLLLLLL 307
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
8-121 3.09e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.12  E-value: 3.09e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720424137   8 NSLGNfglyLPNLIQLKLNHSYLGSLRDLGTSLGHLQVLWLARCGLTDLDGIGSFLELKELYVSYNNISDLSPLCLLEQL 87
Cdd:COG4886   199 EPLGN----LTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNL 274

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1720424137  88 EVLDLEGNNVEDLgQMRYLQLCPRLAMLTLEGNL 121
Cdd:COG4886   275 KTLDLSNNQLTDL-KLKELELLLGLNSLLLLLLL 307
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 17-158 1.73e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 66.73  E-value: 1.73e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720424137  17 LPNLIQLKLNHSYLGSLRDLGtSLGHLQVLWLAR------CGLTDLDgigsflELKELYVSY------------------ 72
Cdd:cd21340    45 LTNLTHLYLQNNQIEKIENLE-NLVNLKKLYLGGnrisvvEGLENLT------NLEELHIENqrlppgekltfdprslaa 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720424137  73 ------------NNISDLSPLCLLEQLEVLDLEGNNVEDLGQM-RYLQLCPRLAMLTLEGNLVCLKPdpgpsnkapqgyN 139
Cdd:cd21340   118 lsnslrvlnisgNNIDSLEPLAPLRNLEQLDASNNQISDLEELlDLLSSWPSLRELDLTGNPVCKKP------------K 185

                         170
                  ....*....|....*....
gi 1720424137 140 YRAEVKKLIPQLHVLDEVP 158
Cdd:cd21340   186 YRDKIILASKSLEVLDGKE 204
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 65-96 4.10e-06

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 43.77  E-value: 4.10e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1720424137  65 LKELYVSYNNISDLSPLCLLEQLEVLDLEGNN 96
Cdd:pfam12799   3 LEVLDLSNNQITDIPPLAKLPNLETLDLSGNN 34
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
8-121 3.09e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.12  E-value: 3.09e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720424137   8 NSLGNfglyLPNLIQLKLNHSYLGSLRDLGTSLGHLQVLWLARCGLTDLDGIGSFLELKELYVSYNNISDLSPLCLLEQL 87
Cdd:COG4886   199 EPLGN----LTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNL 274

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1720424137  88 EVLDLEGNNVEDLgQMRYLQLCPRLAMLTLEGNL 121
Cdd:COG4886   275 KTLDLSNNQLTDL-KLKELELLLGLNSLLLLLLL 307
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
9-120 8.96e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 69.96  E-value: 8.96e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720424137   9 SLGNFGLYLPNLIQLKLNHSylgSLRDLGTSLGH---LQVLWLARCGLTDL-DGIGSFLELKELYVSYNNISDLSPLCLL 84
Cdd:COG4886   173 DLPEELGNLTNLKELDLSNN---QITDLPEPLGNltnLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNL 249

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1720424137  85 EQLEVLDLEGNNVEDLGQMRYLQlcpRLAMLTLEGN 120
Cdd:COG4886   250 TNLEELDLSNNQLTDLPPLANLT---NLKTLDLSNN 282
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
17-120 9.98e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 69.58  E-value: 9.98e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720424137  17 LPNLIQLKLNHSYLGSLRDLGTSLGHLQVLWLARCGLTDL-DGIGSFLELKELYVSYNNISDLS-PLCLLEQLEVLDLEG 94
Cdd:COG4886   135 LTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLPePLGNLTNLEELDLSG 214

                          90       100
                  ....*....|....*....|....*.
gi 1720424137  95 NNVEDLGQmrYLQLCPRLAMLTLEGN 120
Cdd:COG4886   215 NQLTDLPE--PLANLTNLETLDLSNN 238
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 17-158 1.73e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 66.73  E-value: 1.73e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720424137  17 LPNLIQLKLNHSYLGSLRDLGtSLGHLQVLWLAR------CGLTDLDgigsflELKELYVSY------------------ 72
Cdd:cd21340    45 LTNLTHLYLQNNQIEKIENLE-NLVNLKKLYLGGnrisvvEGLENLT------NLEELHIENqrlppgekltfdprslaa 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720424137  73 ------------NNISDLSPLCLLEQLEVLDLEGNNVEDLGQM-RYLQLCPRLAMLTLEGNLVCLKPdpgpsnkapqgyN 139
Cdd:cd21340   118 lsnslrvlnisgNNIDSLEPLAPLRNLEQLDASNNQISDLEELlDLLSSWPSLRELDLTGNPVCKKP------------K 185

                         170
                  ....*....|....*....
gi 1720424137 140 YRAEVKKLIPQLHVLDEVP 158
Cdd:cd21340   186 YRDKIILASKSLEVLDGKE 204
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
5-120 6.26e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 61.10  E-value: 6.26e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720424137   5 TRKNSLGNFGLYLPNLIQLK-LNHSYLGSLRDLGtSLGHLQVLWLARCGLTDL-DGIGSFLELKELYVSYNNISDL-SPL 81
Cdd:COG4886    77 LSLLLLSLLLLGLTDLGDLTnLTELDLSGNEELS-NLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPL 155

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1720424137  82 CLLEQLEVLDLEGNNVEDLGqmRYLQLCPRLAMLTLEGN 120
Cdd:COG4886   156 GNLTNLKSLDLSNNQLTDLP--EELGNLTNLKELDLSNN 192
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 65-96 4.10e-06

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 43.77  E-value: 4.10e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1720424137  65 LKELYVSYNNISDLSPLCLLEQLEVLDLEGNN 96
Cdd:pfam12799   3 LEVLDLSNNQITDIPPLAKLPNLETLDLSGNN 34
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
17-112 8.80e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 48.01  E-value: 8.80e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720424137  17 LPNLIQLKLNHSYLGSLRDLGtSLGHLQVLWLARCGLTDLDGIGSFLELKELYVSYNNISDLSplclLEQLEVLDLEGNN 96
Cdd:COG4886   227 LTNLETLDLSNNQLTDLPELG-NLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLK----LKELELLLGLNSL 301

                          90
                  ....*....|....*.
gi 1720424137  97 VEDLGQMRYLQLCPRL 112
Cdd:COG4886   302 LLLLLLLNLLELLILL 317
LRR_8 pfam13855
Leucine rich repeat;
42-97 1.16e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.90  E-value: 1.16e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720424137  42 HLQVLWLARCGLTDLDGiGSFL---ELKELYVSYNNISDLSPLCL--LEQLEVLDLEGNNV 97
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDD-GAFKglsNLKVLDLSNNLLTTLSPGAFsgLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 42-81 3.16e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 41.08  E-value: 3.16e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1720424137  42 HLQVLWLARCGLTDLDGIGSFLELKELYVSYNN-ISDLSPL 81
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNkITDLSDL 42
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 23-107 1.26e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.24  E-value: 1.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720424137  23 LKLNHSYLGSLRDLGtSLGHLQVLWLARCGLTDLDGIGSFLELKELYVSYNNISDLSPLCLLEQLEVLDLEGNN---VED 99
Cdd:cd21340     7 LYLNDKNITKIDNLS-LCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRisvVEG 85


                  ....*...
gi 1720424137 100 LGQMRYLQ 107
Cdd:cd21340    86 LENLTNLE 93
LRR_8 pfam13855
Leucine rich repeat;
64-122 2.44e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.04  E-value: 2.44e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720424137  64 ELKELYVSYNNISDLSPLCL--LEQLEVLDLEGNNVEDLGqMRYLQLCPRLAMLTLEGNLV 122
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFkgLSNLKVLDLSNNLLTTLS-PGAFSGLPSLRYLDLSGNRL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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