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Conserved domains on  [gi|1720357800|ref|XP_030099574|]
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deubiquitinase DESI2 isoform X1 [Mus musculus]

Protein Classification

C97 family peptidase( domain architecture ID 10531274)

C97 family peptidase (deubiquitinating isopeptidase PPPDE superfamily) such as the deSUMOylase DeSI-1, which reverses post-translational modification by the small ubiquitin-like modifier (SUMO)

EC:  3.4.-.-
Gene Ontology:  GO:0008234|GO:0006508
MEROPS:  C97
PubMed:  22370726|28483520|15483401

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Peptidase_C97 pfam05903
PPPDE putative peptidase domain; The PPPDE superfamily (after Permuted Papain fold Peptidases ...
 4-133 5.43e-52

PPPDE putative peptidase domain; The PPPDE superfamily (after Permuted Papain fold Peptidases of DsRNA viruses and Eukaryotes), consists of predicted thiol peptidases with a circularly permuted papain-like fold. The inference of the likely DUB function of the PPPDE superfamily proteins is based on the fusions of the catalytic domain to Ub-binding PUG (PUB)/UBA domains and a novel alpha-helical Ub-associated domain (the PUL domain, after PLAP, Ufd3p and Lub1p).


:

Pssm-ID: 461775  Cd Length: 151  Bit Score: 163.27  E-value: 5.43e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720357800   4 YTSSIGI---GVFHSGIEVYGREFAYGGHPYPFSGIFEISPGNASElgeTFKFKEAVVLGSTDFLEDDIEKIVEELGKEY 80
Cdd:pfam05903  22 YPTLLGKqidGIFHTGVEVYGVEYFFGGHEKGSGGIFELPPGTTCP---GFTPRESIDIGTTEVTEEEVRDYLEELSEEY 98

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1720357800  81 KGNAYHLMHKNCNHFSSALSEILCGKEIPRWINRLAYFSSCIPFLQSCLPKEW 133
Cdd:pfam05903  99 TGDKYNLLSNNCNHFTDELCQFLTGKPIPSWINRLARIVLSTPFGQCLLPMLL 151
 
Name Accession Description Interval E-value
Peptidase_C97 pfam05903
PPPDE putative peptidase domain; The PPPDE superfamily (after Permuted Papain fold Peptidases ...
 4-133 5.43e-52

PPPDE putative peptidase domain; The PPPDE superfamily (after Permuted Papain fold Peptidases of DsRNA viruses and Eukaryotes), consists of predicted thiol peptidases with a circularly permuted papain-like fold. The inference of the likely DUB function of the PPPDE superfamily proteins is based on the fusions of the catalytic domain to Ub-binding PUG (PUB)/UBA domains and a novel alpha-helical Ub-associated domain (the PUL domain, after PLAP, Ufd3p and Lub1p).


Pssm-ID: 461775  Cd Length: 151  Bit Score: 163.27  E-value: 5.43e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720357800   4 YTSSIGI---GVFHSGIEVYGREFAYGGHPYPFSGIFEISPGNASElgeTFKFKEAVVLGSTDFLEDDIEKIVEELGKEY 80
Cdd:pfam05903  22 YPTLLGKqidGIFHTGVEVYGVEYFFGGHEKGSGGIFELPPGTTCP---GFTPRESIDIGTTEVTEEEVRDYLEELSEEY 98

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1720357800  81 KGNAYHLMHKNCNHFSSALSEILCGKEIPRWINRLAYFSSCIPFLQSCLPKEW 133
Cdd:pfam05903  99 TGDKYNLLSNNCNHFTDELCQFLTGKPIPSWINRLARIVLSTPFGQCLLPMLL 151
 
Name Accession Description Interval E-value
Peptidase_C97 pfam05903
PPPDE putative peptidase domain; The PPPDE superfamily (after Permuted Papain fold Peptidases ...
 4-133 5.43e-52

PPPDE putative peptidase domain; The PPPDE superfamily (after Permuted Papain fold Peptidases of DsRNA viruses and Eukaryotes), consists of predicted thiol peptidases with a circularly permuted papain-like fold. The inference of the likely DUB function of the PPPDE superfamily proteins is based on the fusions of the catalytic domain to Ub-binding PUG (PUB)/UBA domains and a novel alpha-helical Ub-associated domain (the PUL domain, after PLAP, Ufd3p and Lub1p).


Pssm-ID: 461775  Cd Length: 151  Bit Score: 163.27  E-value: 5.43e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720357800   4 YTSSIGI---GVFHSGIEVYGREFAYGGHPYPFSGIFEISPGNASElgeTFKFKEAVVLGSTDFLEDDIEKIVEELGKEY 80
Cdd:pfam05903  22 YPTLLGKqidGIFHTGVEVYGVEYFFGGHEKGSGGIFELPPGTTCP---GFTPRESIDIGTTEVTEEEVRDYLEELSEEY 98

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1720357800  81 KGNAYHLMHKNCNHFSSALSEILCGKEIPRWINRLAYFSSCIPFLQSCLPKEW 133
Cdd:pfam05903  99 TGDKYNLLSNNCNHFTDELCQFLTGKPIPSWINRLARIVLSTPFGQCLLPMLL 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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