NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1720364838|ref|XP_030101574|]
View 

nuclear receptor corepressor 1 isoform X33 [Mus musculus]

Protein Classification

nuclear receptor corepressor 1( domain architecture ID 15502538)

nuclear receptor corepressor 1 (NCOR1) is a transcriptional coregulatory protein which assists nuclear receptors in the down regulation of gene expression

CATH:  1.20.58.1880
Gene Ontology:  GO:0006355|GO:0003700|GO:0003677
PubMed:  8882580|20084085
SCOP:  4000317

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
GPS2_interact super family cl24372
G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain ...
 150-239 6.24e-27

G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain of two co-repressor protein-families found in vertebrates. The domain is found in NCoR and SMRT proteins; N-CoR (nuclear receptor co-repressor) and SMRT (silencing mediator for retinoid and thyroid receptors) are related corepressors that mediate transcriptional repression by unliganded nuclear receptors and other classes of transcriptional repressors. GPS2 is a stoichiometric subunit of the N-CoR-HDAC3 complex. GPS2 links the complex to membrane receptor-related intracellular JNK (c-Jun amino-terminal kinase) signalling pathways.


The actual alignment was detected with superfamily member pfam15784:

Pssm-ID: 464868 [Multi-domain]  Cd Length: 89  Bit Score: 106.48  E-value: 6.24e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720364838  150 FGSKHEAPSSPLAGqPCGDDQNASPSKLSKEELIQSMDRVDREIAKVEQQILKLKKKQQQLEEEAAKPPEPEKPVSPPPV 229
Cdd:pfam15784    1 YYPQVEAISPTLPS-PEGQDQELSPFRSSKDELLQNIDKVDREIAKVEQQISKLKKKQQQLEEEAAKPPEPEEPVSPPPS 79

                           90
                   ....*....|
gi 1720364838  230 EQKHRSIVQI 239
Cdd:pfam15784   80 ESKHRSLAQI 89
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 637-680 6.10e-12

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


:

Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 62.14  E-value: 6.10e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1720364838  637 RWTEEEMEVAKKGLVEHGRNWAAIAKMVGTKSEAQCKNFYFNYK 680
Cdd:pfam00249    3 PWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 450-492 1.26e-04

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


:

Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 41.41  E-value: 1.26e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1720364838  450 WTDHEKEIFKDKFIQHP-KNFGLIASYLERKSVPDCVLYYYLTK 492
Cdd:cd00167      2 WTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNLL 45
MDN1 super family cl34967
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 720-867 2.65e-03

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG5271:

Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 43.08  E-value: 2.65e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720364838  720 STVSAQEDEDIEASNEEENPEDSEAVPTTKPAERESVEAQVTDSASAETAEPMDVDHEECGAEGSSVLDppAPTKADSVD 799
Cdd:COG5271    697 ETEEADEDAETASEEADAEEADTEADGTAEEAEEAAEEAESADEEAASLPDEADAEEEAEEAEEAEEDD--ADGLEEALE 774

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720364838  800 PEMQVPENTASKGEGDAKERDLESTSEKTEARDEDVVVAEQIE--------RPEPQSDDDSSATCSADEGVDGEPE 867
Cdd:COG5271    775 EEKADAEEAATDEEAEAAAEEKEKVADEDQDTDEDALLDEAEAdeeedldgEDEETADEALEDIEAGIAEDDEEDD 850
 
Name Accession Description Interval E-value
GPS2_interact pfam15784
G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain ...
 150-239 6.24e-27

G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain of two co-repressor protein-families found in vertebrates. The domain is found in NCoR and SMRT proteins; N-CoR (nuclear receptor co-repressor) and SMRT (silencing mediator for retinoid and thyroid receptors) are related corepressors that mediate transcriptional repression by unliganded nuclear receptors and other classes of transcriptional repressors. GPS2 is a stoichiometric subunit of the N-CoR-HDAC3 complex. GPS2 links the complex to membrane receptor-related intracellular JNK (c-Jun amino-terminal kinase) signalling pathways.


Pssm-ID: 464868 [Multi-domain]  Cd Length: 89  Bit Score: 106.48  E-value: 6.24e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720364838  150 FGSKHEAPSSPLAGqPCGDDQNASPSKLSKEELIQSMDRVDREIAKVEQQILKLKKKQQQLEEEAAKPPEPEKPVSPPPV 229
Cdd:pfam15784    1 YYPQVEAISPTLPS-PEGQDQELSPFRSSKDELLQNIDKVDREIAKVEQQISKLKKKQQQLEEEAAKPPEPEEPVSPPPS 79

                           90
                   ....*....|
gi 1720364838  230 EQKHRSIVQI 239
Cdd:pfam15784   80 ESKHRSLAQI 89
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 637-680 6.10e-12

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 62.14  E-value: 6.10e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1720364838  637 RWTEEEMEVAKKGLVEHGRNWAAIAKMVGTKSEAQCKNFYFNYK 680
Cdd:pfam00249    3 PWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 637-680 1.32e-10

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 58.36  E-value: 1.32e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1720364838  637 RWTEEEMEVAKKGLVEHG-RNWAAIAKMVGTKSEAQCKNFYFNYK 680
Cdd:cd00167      1 PWTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
637-682 2.10e-10

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 58.00  E-value: 2.10e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 1720364838   637 RWTEEEMEVAKKGLVEHG-RNWAAIAKMVGTKSEAQCKNFYFNYKRR 682
Cdd:smart00717    3 EWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 450-492 1.26e-04

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 41.41  E-value: 1.26e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1720364838  450 WTDHEKEIFKDKFIQHP-KNFGLIASYLERKSVPDCVLYYYLTK 492
Cdd:cd00167      2 WTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
448-493 3.89e-04

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 40.28  E-value: 3.89e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 1720364838   448 NVWTDHEKEIFKDKFIQHP-KNFGLIASYLERKSVPDCVLYYYLTKK 493
Cdd:smart00717    2 GEWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLK 48
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 450-489 5.17e-04

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 39.79  E-value: 5.17e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1720364838  450 WTDHEKEIFKDKFIQHPKNFGLIASYLERKSVPDCVLYYY 489
Cdd:pfam00249    4 WTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQ 43
MDN1 COG5271
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 720-867 2.65e-03

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 43.08  E-value: 2.65e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720364838  720 STVSAQEDEDIEASNEEENPEDSEAVPTTKPAERESVEAQVTDSASAETAEPMDVDHEECGAEGSSVLDppAPTKADSVD 799
Cdd:COG5271    697 ETEEADEDAETASEEADAEEADTEADGTAEEAEEAAEEAESADEEAASLPDEADAEEEAEEAEEAEEDD--ADGLEEALE 774

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720364838  800 PEMQVPENTASKGEGDAKERDLESTSEKTEARDEDVVVAEQIE--------RPEPQSDDDSSATCSADEGVDGEPE 867
Cdd:COG5271    775 EEKADAEEAATDEEAEAAAEEKEKVADEDQDTDEDALLDEAEAdeeedldgEDEETADEALEDIEAGIAEDDEEDD 850
 
Name Accession Description Interval E-value
GPS2_interact pfam15784
G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain ...
 150-239 6.24e-27

G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain of two co-repressor protein-families found in vertebrates. The domain is found in NCoR and SMRT proteins; N-CoR (nuclear receptor co-repressor) and SMRT (silencing mediator for retinoid and thyroid receptors) are related corepressors that mediate transcriptional repression by unliganded nuclear receptors and other classes of transcriptional repressors. GPS2 is a stoichiometric subunit of the N-CoR-HDAC3 complex. GPS2 links the complex to membrane receptor-related intracellular JNK (c-Jun amino-terminal kinase) signalling pathways.


Pssm-ID: 464868 [Multi-domain]  Cd Length: 89  Bit Score: 106.48  E-value: 6.24e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720364838  150 FGSKHEAPSSPLAGqPCGDDQNASPSKLSKEELIQSMDRVDREIAKVEQQILKLKKKQQQLEEEAAKPPEPEKPVSPPPV 229
Cdd:pfam15784    1 YYPQVEAISPTLPS-PEGQDQELSPFRSSKDELLQNIDKVDREIAKVEQQISKLKKKQQQLEEEAAKPPEPEEPVSPPPS 79

                           90
                   ....*....|
gi 1720364838  230 EQKHRSIVQI 239
Cdd:pfam15784   80 ESKHRSLAQI 89
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 637-680 6.10e-12

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 62.14  E-value: 6.10e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1720364838  637 RWTEEEMEVAKKGLVEHGRNWAAIAKMVGTKSEAQCKNFYFNYK 680
Cdd:pfam00249    3 PWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 637-680 1.32e-10

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 58.36  E-value: 1.32e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1720364838  637 RWTEEEMEVAKKGLVEHG-RNWAAIAKMVGTKSEAQCKNFYFNYK 680
Cdd:cd00167      1 PWTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
637-682 2.10e-10

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 58.00  E-value: 2.10e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 1720364838   637 RWTEEEMEVAKKGLVEHG-RNWAAIAKMVGTKSEAQCKNFYFNYKRR 682
Cdd:smart00717    3 EWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 450-492 1.26e-04

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 41.41  E-value: 1.26e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1720364838  450 WTDHEKEIFKDKFIQHP-KNFGLIASYLERKSVPDCVLYYYLTK 492
Cdd:cd00167      2 WTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
448-493 3.89e-04

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 40.28  E-value: 3.89e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 1720364838   448 NVWTDHEKEIFKDKFIQHP-KNFGLIASYLERKSVPDCVLYYYLTKK 493
Cdd:smart00717    2 GEWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLK 48
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 450-489 5.17e-04

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 39.79  E-value: 5.17e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1720364838  450 WTDHEKEIFKDKFIQHPKNFGLIASYLERKSVPDCVLYYY 489
Cdd:pfam00249    4 WTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQ 43
SANT_MTA3_like cd11661
Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family ...
 450-493 9.53e-04

Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family include domains found in mouse metastasis-associated protein 3 (MTA3) proteins and arginine-glutamic dipeptide (RERE) repeats proteins. SANT (SWI3, ADA2, N-CoR and TFIIIB) DNA-binding domains are a diverse set of proteins that share a common 3 alpha-helix bundle. MTA3 has been shown to interact with nucleosome remodeling and deacetylase (NuRD) proteins CHD4 and HDAC1, and the core cohesin complex protein RAD21 in the ovary, and regulate G2/M progression in proliferating granulosa cells. RERE belongs to the atrophin family and has been identified as a nuclear receptor corepressor; altered expression levels of RERE are associated with cancer in humans while mutations of Rere in mice cause failure in closing the anterior neural tube and fusion of the telencephalic and optic vesicles during embryogenesis.


Pssm-ID: 212559 [Multi-domain]  Cd Length: 46  Bit Score: 39.13  E-value: 9.53e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1720364838  450 WTDHEKEIFKDKFIQHPKNFGLI-ASYLERKSVPDCVLYYYLTKK 493
Cdd:cd11661      2 WSESEAKLFEEGLRKYGKDFHDIrQDFLPWKSVGELVEFYYMWKK 46
MDN1 COG5271
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 720-867 2.65e-03

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 43.08  E-value: 2.65e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720364838  720 STVSAQEDEDIEASNEEENPEDSEAVPTTKPAERESVEAQVTDSASAETAEPMDVDHEECGAEGSSVLDppAPTKADSVD 799
Cdd:COG5271    697 ETEEADEDAETASEEADAEEADTEADGTAEEAEEAAEEAESADEEAASLPDEADAEEEAEEAEEAEEDD--ADGLEEALE 774

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720364838  800 PEMQVPENTASKGEGDAKERDLESTSEKTEARDEDVVVAEQIE--------RPEPQSDDDSSATCSADEGVDGEPE 867
Cdd:COG5271    775 EEKADAEEAATDEEAEAAAEEKEKVADEDQDTDEDALLDEAEAdeeedldgEDEETADEALEDIEAGIAEDDEEDD 850
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 638-685 3.06e-03

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 38.06  E-value: 3.06e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1720364838  638 WTEEEMEVAKKGLVEHGRNWAAIAKMVGTKSEAQCKnFYFNYKRRHNL 685
Cdd:pfam13921    1 WTEEEDEKLLKLVEKYGNDWKQIAKELGRRTPKQCF-DRWRRKLNPKI 47
MDN1 COG5271
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 718-867 5.90e-03

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 41.92  E-value: 5.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720364838  718 VASTVSAQEDEDIEASNEEENPEDSEAVPTTKPAERESVEAQVTDSASAETAEPMDVDHEECGAEGssvlDPPAPTKADS 797
Cdd:COG5271    380 DTDAAADEADAAADDSADDEEASADGGTSPTSDTDEEEEEADEDASAGETEDESTDVTSAEDDIAT----DEEADSLADE 455

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720364838  798 VDPEMQVPENTASKGEGDAKERDLESTSEKTEARDEDVVVAEQIERPEPQSDDDSSATCSADEGVDGEPE 867
Cdd:COG5271    456 EEEAEAELDTEEDTESAEEDADGDEATDEDDASDDGDEEEAEEDAEAEADSDELTAEETSADDGADTDAA 525
MDN1 COG5271
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 726-870 6.47e-03

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 41.92  E-value: 6.47e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720364838  726 EDEDIEASNEEENPEDSEAVPTTKPAERESVEAQVTDSASAETAEPMDVDHEECGAEGSS-VLDPPAPTKADSVDPEMQv 804
Cdd:COG5271    514 TSADDGADTDAAADPEDSDEDALEDETEGEENAPGSDQDADETDEPEATAEEDEPDEAEAeTEDATENADADETEESAD- 592

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720364838  805 pENTASKGEGDAKERDLESTSEKTEArDEDVVVAEQIERPEPQSDDDSS----ATCSADEGVDGEPERQR 870
Cdd:COG5271    593 -ESEEAEASEDEAAEEEEADDDEADA-DADGAADEEETEEEAAEDEAAEpetdASEAADEDADAETEAEA 660
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH